			SEQUENCE LISTING

<110> LIANG, Jack
      BORUP, Birthe
      MITCHELL, Vesna
      MUNDORFF, Emily
      LALONDE, James
      HUISMAN, Gjalt

<120> KETOREDUCTASE POLYPEPTIDES AND USES THEREOF

<130> 376247-018

<141> 2008-09-26

<150> 60/976,345
<150> 2007-09-28


<160> 139

<210> 1
<211> 762
<212> DNA
<213> Artificial Sequence

<220>
<223> Codon Optimized L. Brevis Sequence


<400> 1
atgtctaacc gtctggatgg caaagtagcc atcattaccg gcgggactct gggtatcggt 60
ttggcaatcg ccacgaaatt tgtagaggag ggtgcgaaag taatgattac tggtcgtcac 120
tccgatgtag gtgaaaaggc cgccaaatca gtaggcactc cggatcagat tcagtttttt 180
cagcacgatt catccgatga agatggctgg acgaaactgt tcgacgccac cgagaaagca 240
ttcggcccgg ttagcacctt agtgaacaat gcagggattg cagttaacaa aagcgttgaa 300
gaaactacca cggccgaatg gcgtaaactg ctggccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggtt cgtaggcgat ccgagcctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggctat atcaagaccc cgctggtcga tgatctgccg 600
ggtgctgagg aagcgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catatatctg tgtgtacctg gcatctaatg aatcgaaatt tgcgacgggt 720
tccgaatttg tggtcgacgg cgggtatacc gcacagtaat ga                    762


<210> 2
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Translation of Codon Optimized L. Brevis Sequence


<400> 2
Met Ser Asn Arg Leu Asp Gly Lys Val Ala Ile Ile Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Thr Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Met Ile Thr Gly Arg His Ser Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Val Gly Thr Pro Asp Gln Ile Gln Phe Phe Gln His Asp Ser 
    50                  55                  60                  
Ser Asp Glu Asp Gly Trp Thr Lys Leu Phe Asp Ala Thr Glu Lys Ala 
65                  70                  75                  80  
Phe Gly Pro Val Ser Thr Leu Val Asn Asn Ala Gly Ile Ala Val Asn 
                85                  90                  95      
Lys Ser Val Glu Glu Thr Thr Thr Ala Glu Trp Arg Lys Leu Leu Ala 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Phe Val Gly Asp Pro Ser Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Tyr Ile Lys 
            180                 185                 190         
Thr Pro Leu Val Asp Asp Leu Pro Gly Ala Glu Glu Ala Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Tyr Ile Cys Val Tyr Leu Ala Ser Asn Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ser Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 3
<211> 759
<212> DNA
<213> Artificial Sequence


<220>
<223> Codon Optimized L. Kefir Sequence


<400> 3
atgaccgatc gtctgaaggg caaagtagcc atcgtaaccg gcgggactct gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagtttccaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggtt cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggctat atcaagaccc cgctggtcga tgatctggaa 600
ggtgctgagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 4
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Translation of Codon Optimized L. kefir Sequence


<400> 4
Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Phe Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Tyr Ile Lys 
            180                 185                 190         
Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 5
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 5
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccaccaaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcgaca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 6
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 6
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Thr Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Asp Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 7
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 7
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccaccaaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcgaca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacgccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 8
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 8
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Thr Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Asp Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Ala Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 9
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 9
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtctttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggtt ggttggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtatctccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 10
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 10
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Ser Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 11
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 11
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg cgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtagg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 12
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 12
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Arg Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 13
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 13
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tcagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 14
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 14
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Gln Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 15
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 15
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 16
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 16
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 17
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 17
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtagtgccta tgggccgcat tggcgaaccg 660
aatgacgtcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 18
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 18
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Val Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Val Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 19
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 19
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgtccctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tcagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 20
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 20
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Ser Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Gln Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 21
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 21
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcataca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 22
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 22
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 23
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 23
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 24
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 24
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 25
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 25
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 26
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 26
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 27
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 27
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaata cgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 28
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 28
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Tyr Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 29
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 29
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 30
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 30
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 31
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 31
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttgt gcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcgattc gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaattcg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 32
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 32
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Val Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Ile Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 33
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 33
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttgt gcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggtt gattggcgat ccgacgctgg gggcgtacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggttt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg ttaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 34
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 34
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Val Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Ile Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Val Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Leu Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 35
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 35
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacaat gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttgt gcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggtt ggttggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 36
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 36
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Met Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Val Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 37
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 37
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttatcac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaacta ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 38
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 38
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 39
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 39
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgtcat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggtccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcaacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 40
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 40
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 41
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 41
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 42
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 42
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 43
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 43
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttgtgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 44
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 44
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Val 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 45
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 45
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttttaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 46
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 46
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 47
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 47
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg catccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gagtttccaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 48
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 48
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Ser 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 49
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 49
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg catccgatga agtgggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcataaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtaacatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagacct ctcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg atcaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaattcg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 50
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 50
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Val Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Asn Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Ser Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Ile Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 51
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 51
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgagattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 52
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 52
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Glu Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 53
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 53
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctatccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat gcgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 54
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 54
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Ala Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 55
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 55
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tcagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 56
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 56
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Gln Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 57
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 57
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 58
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 58
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 59
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 59
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgtctctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 60
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 60
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Ser Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 61
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 61
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttattca tagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgcc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 62
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 62
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Ile 
                85                  90                  95      
His Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 63
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 63
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttcaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 64
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 64
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Gln Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 65
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 65
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg ggcttgtgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag tatcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 66
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 66
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Leu Val 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 67
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 67
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg ttaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 68
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 68
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Leu Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 69
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 69
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgtgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 70
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 70
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 71
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 71
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg gggttgtgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgtcgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatggaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 72
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 72
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Gly Val Val 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Ser Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Trp Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 73
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 73
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggtt 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttgtgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg acaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 74
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 74
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Val 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Val 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Thr Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 75
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 75
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgaaga agcaggctgg acgaaactgt tcgacaccac cgaggaggtt 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg ttaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 76
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 76
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Glu Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Val 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Leu Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 77
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 77
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcataaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtaacatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc gcagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 78
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 78
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Asn Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 79
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 79
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggacctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 80
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 80
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Thr Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 81
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 81
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 82
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 82
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 83
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 83
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 84
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 84
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 85
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 85
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 86
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 86
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 87
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 87
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg ataaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 88
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 88
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Ile Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 89
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 89
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759

 
<210> 90
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 90
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 91
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 91
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtggacc gcacagtga                        759


<210> 92
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 92
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Trp Thr Ala Gln                 
                245                 250                         


<210> 93
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 93
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gttaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 94
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 94
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 95
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 95
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cggatctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 96
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 96
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Asp Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 97
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 97
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc tgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 98
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 98
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Leu Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 99
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 99
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttttggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg aaaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 100
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 100
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Leu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 101
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 101
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cagttacaaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggtgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgctgctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg attaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 102
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 102
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Thr 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Leu Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Ile Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 103
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 103
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattt gcgttattaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg acaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 104
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 104
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Cys Val Ile 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Thr Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 105
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 105
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agcaggctgg acgaaactgt tcgacaccac cgaggaggtt 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggattg cggtgtgtaa aagcgttgaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcgtctcga tgatctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 106
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 106
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Val 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Cys 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Asp Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 107
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 107
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg cgtccgatga agtgggctgg acgaaactgt tcgacaccac cgaggaggca 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttaaa aagcgttgaa 300
gacactacca cggaggaatg gcataaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct tgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactttgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc cgcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccacat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg cgggtatacc gcacagtga                        759


<210> 108
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 108
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Val Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp His Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Phe Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Pro Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 109
<211> 759
<212> DNA
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 109
atgaccgatc gtctgaagca taaagtagcc atcgtaaccg gcgggacact gggtatcggt 60
ttggcaatcg ccgataaatt tgtagaggag ggtgcgaaag tagttattac tggtcgtcac 120
gcggatgtag gtgaaaaggc cgccaaatca atcggcggca ctgatgttat tcgctttgtc 180
cagcacgatg tctccgatga agcaggctgg acgaaactgt tcgacaccac cgaggagacc 240
ttcggcccgg ttacgaccgt cgtgaacaat gcagggagtt gcgttttgaa aagcgttaaa 300
gacactacca cggaggaatg gcgtaaactg ctgtccgtta atctggatgg tgtttttttc 360
ggcacccgtc tgggcattca gcgcatgaaa aataaaggct tgggcgctag catcatcaat 420
atgagcagta ttgaggggct cgtaggcgat ccgacgctgg gggcatacaa cgcttccaag 480
ggggcggtac gtatcatgtc gaaaagcgca gcgctggatt gcgcactgaa ggactacgat 540
gtgcgtgtca acacagtaca tccgggcccc atcaagaccc agcggctcga tgagctggaa 600
ggttgggagg aaatgatgtc acagcgtacg gtaaccccta tgggccgcat tggcgaaccg 660
aatgacatcg catggatctg tgtgtacctg gcatctgacg aatcgaaatt tgcgacgggt 720
gcagaatttg tggtcgacgg tgggtatacc gcacagtga                        759


<210> 110
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Variant of L. kefir


<400> 110
Met Thr Asp Arg Leu Lys His Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Val 
    50                  55                  60                  
Ser Asp Glu Ala Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Thr 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ser Cys Val Leu 
                85                  90                  95      
Lys Ser Val Lys Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Leu Val Gly Asp Pro Thr Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Pro Ile Lys 
            180                 185                 190         
Thr Gln Arg Leu Asp Glu Leu Glu Gly Trp Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Val Thr Pro Met Gly Arg Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 111
<211> 252
<212> PRT
<213> Artificial Sequence

<220>
<223> Engineered Ketoreductase Sequence Formula with L. brevis backbone
<223> Synthetic Construct

<220>
<221> MISC_FEATURE
<222>(7)..(7)
<223> Xaa is a constrained or non-polar residue

<220>
<221> MISC_FEATURE
<222>(17)..(17)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(25)..(25)
<223> Xaa is a polar or acidic residue

<220>
<221> MISC_FEATURE
<222>(27)..(27)
<223> Xaa is an aromatic residue

<220>
<221> MISC_FEATURE
<222>(41)..(41)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(53)..(53)
<223> Xaa is a polar, non-polar, or acidic residue

<220>
<221> MISC_FEATURE
<222>(57)..(57)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(64)..(64)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(66)..(66)
<223> Xaa is an acidic residue

<220>
<221> MISC_FEATURE
<222>(68)..(68)
<223> Xaa is a polar, acidic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(72)..(72)
<223> Xaa is a basic residue

<220>
<221> MISC_FEATURE
<222>(76)..(76)
<223> Xaa is an aliphatic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(80)..(80)
<223> Xaa is an aliphatic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(93)..(93)
<223> Xaa is is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(94)..(94)
<223> Xaa is a cysteine, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(95)..(95)
<223> Xaa is an aliphatic, non-polar, or acidic residue

<220>
<221> MISC_FEATURE
<222>(96)..(96)
<223> Xaa is is a cyteine, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(97)..(97)
<223> Xaa is a constrained or polar residue

<220>
<221> MISC_FEATURE
<222>(100)..(100)
<223> Xaa is a basic, acidic, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(108)..(108)
<223> Xaa is a basic or constrained residue

<220>
<221> MISC_FEATURE
<222>(111)..(111)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(139)..(139)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(145)..(145)
<223> Xaa is an acidic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(147)..(147)
<223> Xaa is an aromatic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(151)..(151)
<223> Xaa is a constrained, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(152)..(152)
<223> Xaa is a polar, aromatic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(163)..(163)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(165)..(165)
<223> Xaa is a polar, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(173)..(173)
<223> Xaa is an acidic, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(179)..(179)
<223> Xaa is an aromatic, basic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(190)..(190)
<223> Xaa is a constrained residue

<220>
<221> MISC_FEATURE
<222>(194)..(194)
<223> Xaa is a constrained, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(195)..(195)
<223> Xaa is a basic, acidic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(196)..(196)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(197)..(197)
<223> Xaa is an acidic residue

<220>
<221> MISC_FEATURE
<222>(198)..(198)
<223> Xaa is an acidic or polar residue

<220>
<221> MISC_FEATURE
<222>(202)..(202)
<223> Xaa is an aromatic residue

<220>
<221> MISC_FEATURE
<222>(210)..(210)
<223> Xaa is a polar or basic residue

<220>
<221> MISC_FEATURE
<222>(211)..(211)
<223> Xaa is is a basic, aliphatic, non-polar, acidic, or polar residue

<220>
<221> MISC_FEATURE
<222>(212)..(212)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(216)..(216)
<223> Xaa is a constrained or basic residue

<220>
<221> MISC_FEATURE
<222>(223)..(223)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(226)..(226)
<223> Xaa is a non-polar or polar residue

<220>
<221> MISC_FEATURE
<222>(233)..(233)
<223> Xaa is a polar or acidic residue


<220>
<221> MISC_FEATURE
<222>(235)..(235)
<223> Xaa is a polar or aromatic residue

<220>
<221> MISC_FEATURE
<222>(248)..(248)
<223> Xaa is a non-polar or aromatic residue

<220>
<221> MISC_FEATURE
<222>(249)..(249)
<223> Xaa is an aromatic residue


<400> 111
Met Ser Asn Arg Leu Asp Xaa Lys Val Ala Ile Ile Thr Gly Gly Thr 
1               5                   10                  15      
Xaa Gly Ile Gly Leu Ala Ile Ala Xaa Lys Xaa Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Met Ile Thr Gly Arg His Xaa Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Val Gly Xaa Pro Asp Gln Xaa Gln Phe Phe Gln His Asp Xaa 
    50                  55                  60                  
Ser Xaa Glu Xaa Gly Trp Thr Xaa Leu Phe Asp Xaa Thr Glu Lys Xaa 
65                  70                  75                  80  
Phe Gly Pro Val Ser Thr Leu Val Asn Asn Ala Gly Xaa Xaa Xaa Xaa 
                85                  90                  95      
Xaa Ser Val Xaa Glu Thr Thr Thr Ala Glu Trp Xaa Lys Leu Xaa Ala 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Xaa Asn Met Ser Ser Ile 
    130                 135                 140                 
Xaa Gly Xaa Xaa Gly Asp Xaa Xaa Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Xaa Arg Xaa Met Ser Lys Ser Ala Ala Leu Xaa Cys Ala Leu 
                165                 170                 175     
Lys Asp Xaa Asp Val Arg Val Asn Thr Val His Pro Gly Xaa Ile Lys 
            180                 185                 190         
Thr Xaa Xaa Xaa Asp Xaa Leu Pro Gly Xaa Glu Glu Ala Met Ser Gln 
        195                 200                 205             
Arg Xaa Xaa Xaa Pro Met Gly Xaa Ile Gly Glu Pro Asn Asp Xaa Ala 
    210                 215                 220                 
Tyr Xaa Cys Val Tyr Leu Ala Ser Xaa Glu Xaa Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ser Glu Phe Val Val Asp Gly Xaa Xaa Thr Ala Gln                 
                245                 250                         


<210> 112
<211> 252
<212> PRT
<213> Artificial Sequence


<220>
<223> Engineered Ketoreductase Sequence Formula with L. kefir backbone
<223> Synthetic Construct


<220>
<221> MISC_FEATURE
<222>(7)..(7)
<223> Xaa is a constrained or non-polar residue

<220>
<221> MISC_FEATURE
<222>(17)..(17)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(25)..(25)
<223> Xaa is a polar or acidic residue

<220>
<221> MISC_FEATURE
<222>(27)..(27)
<223> Xaa is an aromatic residue

<220>
<221> MISC_FEATURE
<222>(41)..(41)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(53)..(53)
<223> Xaa is a polar, non-polar, or acidic residue

<220>
<221> MISC_FEATURE
<222>(57)..(57)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(64)..(64)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(66)..(66)
<223> Xaa is an acidic residue

<220>
<221> MISC_FEATURE
<222>(68)..(68)
<223> Xaa is a polar, acidic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(72)..(72)
<223> Xaa is a basic residue

<220>
<221> MISC_FEATURE
<222>(76)..(76)
<223> Xaa is an aliphatic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(80)..(80)
<223> Xaa is an aliphatic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(93)..(93)
<223> Xaa is is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(94)..(94)
<223> Xaa is a cysteine, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(95)..(95)
<223> Xaa is an aliphatic, non-polar, or acidic residue

<220>
<221> MISC_FEATURE
<222>(96)..(96)
<223> Xaa is is a cyteine, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(97)..(97)
<223> Xaa is a constrained or polar residue

<220>
<221> MISC_FEATURE
<222>(100)..(100)
<223> Xaa is a basic, acidic, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(108)..(108)
<223> Xaa is a basic or constrained residue

<220>
<221> MISC_FEATURE
<222>(111)..(111)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(139)..(139)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(145)..(145)
<223> Xaa is an acidic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(147)..(147)
<223> Xaa is an aromatic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(151)..(151)
<223> Xaa is a constrained, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(152)..(152)
<223> Xaa is a polar, aromatic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(163)..(163)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(165)..(165)
<223> Xaa is a polar, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(173)..(173)
<223> Xaa is an acidic, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(179)..(179)
<223> Xaa is an aromatic, basic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(190)..(190)
<223> Xaa is a constrained residue

<220>
<221> MISC_FEATURE
<222>(194)..(194)
<223> Xaa is a constrained, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(195)..(195)
<223> Xaa is a basic, acidic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(196)..(196)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(197)..(197)
<223> Xaa is an acidic residue

<220>
<221> MISC_FEATURE
<222>(198)..(198)
<223> Xaa is an acidic or polar residue

<220>
<221> MISC_FEATURE
<222>(202)..(202)
<223> Xaa is an aromatic residue

<220>
<221> MISC_FEATURE
<222>(210)..(210)
<223> Xaa is a polar or basic residue

<220>
<221> MISC_FEATURE
<222>(211)..(211)
<223> Xaa is is a basic, aliphatic, non-polar, acidic, or polar residue

<220>
<221> MISC_FEATURE
<222>(212)..(212)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(216)..(216)
<223> Xaa is a constrained or basic residue

<220>
<221> MISC_FEATURE
<222>(223)..(223)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(226)..(226)
<223> Xaa is a non-polar or polar residue

<220>
<221> MISC_FEATURE
<222>(233)..(233)
<223> Xaa is a polar or acidic residue


<220>
<221> MISC_FEATURE
<222>(235)..(235)
<223> Xaa is a polar or aromatic residue

<220>
<221> MISC_FEATURE
<222>(248)..(248)
<223> Xaa is a non-polar or aromatic residue

<220>
<221> MISC_FEATURE
<222>(249)..(249)
<223> Xaa is an aromatic residue


<400> 112
Met Thr Asp Arg Leu Lys Xaa Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Xaa Gly Ile Gly Leu Ala Ile Ala Xaa Lys Xaa Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Xaa Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Lys Ser Ile Gly Xaa Thr Asp Val Xaa Arg Phe Val Gln His Asp Xaa 
    50                  55                  60                  
Ser Xaa Glu Xaa Gly Trp Thr Xaa Leu Phe Asp Xaa Thr Glu Glu Xaa 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Xaa Xaa Xaa Xaa 
                85                  90                  95      
Xaa Ser Val Xaa Asp Thr Thr Thr Glu Glu Trp Xaa Lys Leu Xaa Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Xaa Asn Met Ser Ser Ile 
    130                 135                 140                 
Xaa Gly Xaa Xaa Gly Asp Xaa Xaa Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Xaa Arg Xaa Met Ser Lys Ser Ala Ala Leu Xaa Cys Ala Leu 
                165                 170                 175     
Lys Asp Xaa Asp Val Arg Val Asn Thr Val His Pro Gly Xaa Ile Lys 
            180                 185                 190         
Thr Xaa Xaa Xaa Xaa Xaa Leu Glu Gly Xaa Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Xaa Xaa Xaa Pro Met Gly Xaa Ile Gly Glu Pro Asn Asp Xaa Ala 
    210                 215                 220                 
Trp Xaa Cys Val Tyr Leu Ala Ser Xaa Glu Xaa Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Xaa Xaa Thr Ala Gln                 
                245                 250                         


<210>  113
<211>  759
<212>  DNA
<213>  Lactobacillus Minor

<400>  113
atgaccgatc ggttgaaggg gaaagtagca attgtaactg gcggtacctt gggaattggc     60
ttggcaatcg ctgataagtt tgttgaagaa ggcgcaaagg ttgttattac cggccgtcac    120
gctgatgtag gtgaaaaagc tgccagatca atcggcggca cagacgttat ccgttttgtc    180
caacacgatg cttctgatga aaccggctgg actaagttgt ttgatacgac tgaagaagca    240
tttggcccag ttaccacggt tgtcaacaat gccggaattg cggtcagcaa gagtgttgaa    300
gataccacaa ctgaagaatg gcgcaagctg ctctcagtta acttggatgg tgtcttcttc    360
ggtacccgtc ttggaatcca acgtatgaag aataaaggac tcggagcatc aatcatcaat    420
atgtcatcta tcgaaggttt tgttggtgat ccagctctgg gtgcatacaa cgcttcaaaa    480
ggtgctgtca gaattatgtc taaatcagct gccttggatt gcgctttgaa ggactacgat    540
gttcgggtta acactgttca tccaggttat atcaagacac cattggttga cgatcttgaa    600
ggggcagaag aaatgatgtc acagcggacc aagacaccaa tgggtcatat cggtgaacct    660
aacgatatcg cttggatctg tgtttacctg gcatctgacg aatctaaatt tgccactggt    720
gcagaattcg ttgtcgacgg agggtacacc gcccaatag                           759


<210>  114
<211>  252
<212>  PRT
<213>  Lactobacillus Minor

<400>  114

Met Thr Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Ala Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Arg Ser Ile Gly Gly Thr Asp Val Ile Arg Phe Val Gln His Asp Ala 
    50                  55                  60                  
Ser Asp Glu Thr Gly Trp Thr Lys Leu Phe Asp Thr Thr Glu Glu Ala 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Ile Ala Val Ser 
                85                  90                  95      
Lys Ser Val Glu Asp Thr Thr Thr Glu Glu Trp Arg Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Glu Gly Phe Val Gly Asp Pro Ala Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Tyr Asp Val Arg Val Asn Thr Val His Pro Gly Tyr Ile Lys 
            180                 185                 190         
Thr Pro Leu Val Asp Asp Leu Glu Gly Ala Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Thr Lys Thr Pro Met Gly His Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Asp Glu Ser Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Gly Tyr Thr Ala Gln                 
                245                 250                         


<210> 115
<211> 1050
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Codon optimized version of the adh gene from Aspergillus flavus
 
<400> 115
atgtctattc cggaaatgca atgggctcaa gtagcggagc agaaaggcgg tccgctgatt 60
tacaaacaga ttccggttcc gaaaccgggc ccggacgaaa tcctggtaaa agtgcgttac 120
tctggtgtgt gccacacgga tctgcacgcg ctgaaaggtg actggccact gcctgtgaaa 180
atgccactgg tgggtggcca tgagggcgcg ggtgttgtcg tcgctcgtgg cgatctggtt 240
actgagttcg aaattggtga ccatgctggc ctgaaatggc tgaacggtag ctgcctggca 300
tgcgagttct gtaaacaggc tgacgaaccg ctgtgcccta acgcgagcct gtctggttat 360
actgtagatg gtactttcca gcagtatgcc attggcaaag ccacccatgc gagcaagctg 420
ccgaaaaacg tgcctctgga tgccgtggca ccggttctgt gcgcgggcat taccgtatac 480
aagggcctga aagaaagcgg tgttcgtcct ggccaaaccg ttgcgatcgt aggtgcgggt 540
ggtggtctgg gctccctggc gctgcagtac gcgaaagcta tgggtattcg cgtggtggcg 600
attgatggcg gtgaagagaa acaagcgatg tgtgaacagc tgggcgcaga agcctacgtt 660
gactttacca aaacgcaaga tctggtagca gatgttaagg ccgccacccc tgaaggtctg 720
ggcgcgcatg cggtaattct gctggcggtc gccgaaaaac catttcagca ggcggccgaa 780
tatgtcagcc gtggtacggt ggttgccatt ggtctgccgg cgggcgcatt cctgcgcgcg 840
ccggtgttta acactgtggt tcgtatgatt aacattaagg gtagctacgt tggcaaccgc 900
caggacggcg ttgaggcagt ggacttcttc gcgcgcggcc tgatcaaagc gccgttcaaa 960
accgctcctc tgcaagatct gccgaaaatc ttcgaactga tggaacaagg taagattgca 1020
ggtcgctacg ttctggaaat cccggaatga                                  1050


<210> 116
<211> 349
<212> PRT
<213> Artificial Sequence

<220>
<223> The adh from Aspergillus flavus


<400> 116
Met Ser Ile Pro Glu Met Gln Trp Ala Gln Val Ala Glu Gln Lys Gly 
1               5                   10                  15      
Gly Pro Leu Ile Tyr Lys Gln Ile Pro Val Pro Lys Pro Gly Pro Asp 
            20                  25                  30          
Glu Ile Leu Val Lys Val Arg Tyr Ser Gly Val Cys His Thr Asp Leu 
        35                  40                  45              
His Ala Leu Lys Gly Asp Trp Pro Leu Pro Val Lys Met Pro Leu Val 
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Ala Arg Gly Asp Leu Val 
65                  70                  75                  80  
Thr Glu Phe Glu Ile Gly Asp His Ala Gly Leu Lys Trp Leu Asn Gly 
                85                  90                  95      
Ser Cys Leu Ala Cys Glu Phe Cys Lys Gln Ala Asp Glu Pro Leu Cys 
            100                 105                 110         
Pro Asn Ala Ser Leu Ser Gly Tyr Thr Val Asp Gly Thr Phe Gln Gln 
        115                 120                 125             
Tyr Ala Ile Gly Lys Ala Thr His Ala Ser Lys Leu Pro Lys Asn Val 
    130                 135                 140                 
Pro Leu Asp Ala Val Ala Pro Val Leu Cys Ala Gly Ile Thr Val Tyr 
145                 150                 155                 160 
Lys Gly Leu Lys Glu Ser Gly Val Arg Pro Gly Gln Thr Val Ala Ile 
                165                 170                 175     
Val Gly Ala Gly Gly Gly Leu Gly Ser Leu Ala Leu Gln Tyr Ala Lys 
            180                 185                 190         
Ala Met Gly Ile Arg Val Val Ala Ile Asp Gly Gly Glu Glu Lys Gln 
        195                 200                 205             
Ala Met Cys Glu Gln Leu Gly Ala Glu Ala Tyr Val Asp Phe Thr Lys 
    210                 215                 220                 
Thr Gln Asp Leu Val Ala Asp Val Lys Ala Ala Thr Pro Glu Gly Leu 
225                 230                 235                 240 
Gly Ala His Ala Val Ile Leu Leu Ala Val Ala Glu Lys Pro Phe Gln 
                245                 250                 255     
Gln Ala Ala Glu Tyr Val Ser Arg Gly Thr Val Val Ala Ile Gly Leu 
            260                 265                 270         
Pro Ala Gly Ala Phe Leu Arg Ala Pro Val Phe Asn Thr Val Val Arg 
        275                 280                 285             
Met Ile Asn Ile Lys Gly Ser Tyr Val Gly Asn Arg Gln Asp Gly Val 
    290                 295                 300                 
Glu Ala Val Asp Phe Phe Ala Arg Gly Leu Ile Lys Ala Pro Phe Lys 
305                 310                 315                 320 
Thr Ala Pro Leu Gln Asp Leu Pro Lys Ile Phe Glu Leu Met Glu Gln 
                325                 330                 335     
Gly Lys Ile Ala Gly Arg Tyr Val Leu Glu Ile Pro Glu             
            340                 345                             


<210> 117
<211> 729
<212> DNA
<213> Artificial Sequence

<220>
<223> Codon optimized version of the adh gene from Oenococcus oeni


<400> 117
atgtttgatc gcctgaaggg taaggtggcg atcgtcaccg gcggtaatag cggtattggt 60
aaggcaatcg cggcagactt catcgccgag ggcgcgaaag tagtgattac cggtcgcaac 120
caagagaagg gtcgccagac tgcgctggaa atcgccggtg acattctgtt cattcagcag 180
gacgtgagcc aggaggcgga ctggcagaaa gttatctcca aaaccatcga gaagttcggt 240
aagtttgata ttctggttaa caacgctggc gtcggcggcg tgggtaagcc actggcagaa 300
atgtccctgt ctgaattcaa ttggacccaa tccattaatc tgtccggtaa cttcctgggt 360
attcacttcg cgctgaacaa aatgaccgaa cctggtagca ttattgacgt aagcagcgcg 420
gctggcctgc gtggttttcc gggcgcagcc gattatagcg cttccaaagg tggtacgcgt 480
ctgctgacgc gcgccgcggc gctggaagcg ctgcaaatgg gtaaaaagat ccgtgtaaac 540
tctattcacc caggttggat tgataccgat atcgtaccaa aagatatgcg tgagcaggtt 600
atcgcgatga cccctatgca tcacctgggc caaccgaaag atattgccaa gctggcgacg 660
tatctggcat ctgacgagtc cgagtatact acgggctccg aactggcagc cgacggcggt 720
ctgatggca                                                         729


<210> 118
<211> 243
<212> PRT
<213> Artificial Sequence

<220>
<223> The adh from Oenococcus oeni


<400> 118
Met Phe Asp Arg Leu Lys Gly Lys Val Ala Ile Val Thr Gly Gly Asn 
1               5                   10                  15      
Ser Gly Ile Gly Lys Ala Ile Ala Ala Asp Phe Ile Ala Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg Asn Gln Glu Lys Gly Arg Gln Thr Ala 
        35                  40                  45              
Leu Glu Ile Ala Gly Asp Ile Leu Phe Ile Gln Gln Asp Val Ser Gln 
    50                  55                  60                  
Glu Ala Asp Trp Gln Lys Val Ile Ser Lys Thr Ile Glu Lys Phe Gly 
65                  70                  75                  80  
Lys Phe Asp Ile Leu Val Asn Asn Ala Gly Val Gly Gly Val Gly Lys 
                85                  90                  95      
Pro Leu Ala Glu Met Ser Leu Ser Glu Phe Asn Trp Thr Gln Ser Ile 
            100                 105                 110         
Asn Leu Ser Gly Asn Phe Leu Gly Ile His Phe Ala Leu Asn Lys Met 
        115                 120                 125             
Thr Glu Pro Gly Ser Ile Ile Asp Val Ser Ser Ala Ala Gly Leu Arg 
    130                 135                 140                 
Gly Phe Pro Gly Ala Ala Asp Tyr Ser Ala Ser Lys Gly Gly Thr Arg 
145                 150                 155                 160 
Leu Leu Thr Arg Ala Ala Ala Leu Glu Ala Leu Gln Met Gly Lys Lys 
                165                 170                 175     
Ile Arg Val Asn Ser Ile His Pro Gly Trp Ile Asp Thr Asp Ile Val 
            180                 185                 190         
Pro Lys Asp Met Arg Glu Gln Val Ile Ala Met Thr Pro Met His His 
        195                 200                 205             
Leu Gly Gln Pro Lys Asp Ile Ala Lys Leu Ala Thr Tyr Leu Ala Ser 
    210                 215                 220                 
Asp Glu Ser Glu Tyr Thr Thr Gly Ser Glu Leu Ala Ala Asp Gly Gly 
225                 230                 235                 240 
Leu Met Ala                                                     
                                                                


<210> 119
<211> 768
<212> DNA
<213> Artificial Sequence

<220>
<223> Codon optimized version of the adh gene from Ralstonia eutropha


<400> 119
atgcagggca aaattgcact ggttacgggc ggtgcgtctg gtatgggtct ggccttcacc 60
cgtcgcctgg cccaagaagg cgcacgtgtt tacttcaccg acattaacgg cgccgcgggt 120
cacgcgacgg aaagcgagct gcagggtgct ggtctggcgg tcgtattcct gcgtcatgac 180
gtgacccagg aaaacgactg gctgcgcgtc ctggaacata ttggcgctgt tgacggtcgc 240
ctggatgtac tggtgaataa tgccggcatt gcgatttctc acaacattga gacttgtact 300
actgaggatt ttgatcgcac gctgaatgtt aacctgaagt ccgtgtttct gggctgcaaa 360
cacggtctgg ctctgatgaa acagaagggt ggcagcatca ttaacgttag ctctatcacc 420
gcgatttgcg gcgaacctgt ggcgctggcg tatagcgcta gcaaagccgg cgtccgtttt 480
ctgagcaagt ctgttgccct gcattgtgcg gagaagggct acgccatccg tgttaacagc 540
ctgcacccgg gttacattga taccccgctg ctggcaggca gcaacgcggg tggctccctg 600
accgctgacg aggtaaccgc gagccgtgta cgtattggcg gtgaaattcc gctgaaacgt 660
cgcggcaccc cggacgaagt tgcaggcgcg gttctgtacc tggctagcga tgaatccacc 720
tatgttactg gtactgagct ggtaattgat ggcggctacg catgtcat              768


<210> 120
<211> 256
<212> PRT
<213> Artificial Sequence

<220>
<223> The adh from Ralstonia eutropha


<400> 120
Met Gln Gly Lys Ile Ala Leu Val Thr Gly Gly Ala Ser Gly Met Gly 
1               5                   10                  15      
Leu Ala Phe Thr Arg Arg Leu Ala Gln Glu Gly Ala Arg Val Tyr Phe 
            20                  25                  30          
Thr Asp Ile Asn Gly Ala Ala Gly His Ala Thr Glu Ser Glu Leu Gln 
        35                  40                  45              
Gly Ala Gly Leu Ala Val Val Phe Leu Arg His Asp Val Thr Gln Glu 
    50                  55                  60                  
Asn Asp Trp Leu Arg Val Leu Glu His Ile Gly Ala Val Asp Gly Arg 
65                  70                  75                  80  
Leu Asp Val Leu Val Asn Asn Ala Gly Ile Ala Ile Ser His Asn Ile 
                85                  90                  95      
Glu Thr Cys Thr Thr Glu Asp Phe Asp Arg Thr Leu Asn Val Asn Leu 
            100                 105                 110         
Lys Ser Val Phe Leu Gly Cys Lys His Gly Leu Ala Leu Met Lys Gln 
        115                 120                 125             
Lys Gly Gly Ser Ile Ile Asn Val Ser Ser Ile Thr Ala Ile Cys Gly 
    130                 135                 140                 
Glu Pro Val Ala Leu Ala Tyr Ser Ala Ser Lys Ala Gly Val Arg Phe 
145                 150                 155                 160 
Leu Ser Lys Ser Val Ala Leu His Cys Ala Glu Lys Gly Tyr Ala Ile 
                165                 170                 175     
Arg Val Asn Ser Leu His Pro Gly Tyr Ile Asp Thr Pro Leu Leu Ala 
            180                 185                 190         
Gly Ser Asn Ala Gly Gly Ser Leu Thr Ala Asp Glu Val Thr Ala Ser 
        195                 200                 205             
Arg Val Arg Ile Gly Gly Glu Ile Pro Leu Lys Arg Arg Gly Thr Pro 
    210                 215                 220                 
Asp Glu Val Ala Gly Ala Val Leu Tyr Leu Ala Ser Asp Glu Ser Thr 
225                 230                 235                 240 
Tyr Val Thr Gly Thr Glu Leu Val Ile Asp Gly Gly Tyr Ala Cys His 
                245                 250                 255     


<210> 121
<211> 939
<212> DNA
<213> Artificial Sequence

<220>
<223> YDL ADH from Saccharomyces cervisiae

<400> 121
atgtcttttc accaacagtt tttcacgctg aacaacggca ataaaatccc ggcgattgcc 60
atcatcggca ctggtacacg ttggtataaa aatgaagaaa ctgacgcgac cttctccaat 120
agtctggttg aacaaatcgt gtatgcgttg aaactgccgg ggattatcca catcgacgcc 180
gcggagattt atcgcaccta cccggaagtg ggtaaagcac tgtccctgac cgaaaagcct 240
cgtaacgcga tttttctgac ggataaatat tctccgcaga ttaaaatgag tgactcccct 300
gcggacggtc tggatttagc attgaagaaa atgggtacag attatgttga tttatatctg 360
ttacattccc cgtttgtttc gaaggaagtg aatggcttaa gcttagaaga ggcttggaaa 420
gatatggagc agttatacaa aagtggtaaa gctaaaaaca tcggggtttc caatttcgca 480
gtggaagacc tgcaacgtat cctgaaagtc gctgaagtta aacctcaggt caaccagatt 540
gagttctctc cgttcctgca aaaccaaaca ccaggcattt ataaattctg tcaggagcac 600
gatatcctgg tggaagcata ttctccgctg ggcccgctgc agaagaaaac cgcgcaggat 660
gacagccaac cattttttga gtacgtcaaa gaattgagcg aaaaatacat caaatccgag 720
gcccagatca tcctgcgctg ggtcactaaa cgcggtgtgc tgccagttac cacctcttca 780
aagcctcagc gcattagcga tgctcagaac ctgttttcct tcgacctgac agcggaagag 840
gttgataaaa tcacggagct gggtctggaa catgaaccgc tgcgcctgta ctggaataaa 900
ttgtatggca aatataacta cgccgcccag aaagtgtaa                        939


<210> 122
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<223> YDL ADH from Saccharomyces cervisiae

<400> 122
Met Ser Phe His Gln Gln Phe Phe Thr Leu Asn Asn Gly Asn Lys Ile 
1               5                   10                  15      
Pro Ala Ile Ala Ile Ile Gly Thr Gly Thr Arg Trp Tyr Lys Asn Glu 
            20                  25                  30          
Glu Thr Asp Ala Thr Phe Ser Asn Ser Leu Val Glu Gln Ile Val Tyr 
        35                  40                  45              
Ala Leu Lys Leu Pro Gly Ile Ile His Ile Asp Ala Ala Glu Ile Tyr 
    50                  55                  60                  
Arg Thr Tyr Pro Glu Val Gly Lys Ala Leu Ser Leu Thr Glu Lys Pro 
65                  70                  75                  80  
Arg Asn Ala Ile Phe Leu Thr Asp Lys Tyr Ser Pro Gln Ile Lys Met 
                85                  90                  95      
Ser Asp Ser Pro Ala Asp Gly Leu Asp Leu Ala Leu Lys Lys Met Gly 
            100                 105                 110         
Thr Asp Tyr Val Asp Leu Tyr Leu Leu His Ser Pro Phe Val Ser Lys 
        115                 120                 125             
Glu Val Asn Gly Leu Ser Leu Glu Glu Ala Trp Lys Asp Met Glu Gln 
    130                 135                 140                 
Leu Tyr Lys Ser Gly Lys Ala Lys Asn Ile Gly Val Ser Asn Phe Ala 
145                 150                 155                 160 
Val Glu Asp Leu Gln Arg Ile Leu Lys Val Ala Glu Val Lys Pro Gln 
                165                 170                 175     
Val Asn Gln Ile Glu Phe Ser Pro Phe Leu Gln Asn Gln Thr Pro Gly 
            180                 185                 190         
Ile Tyr Lys Phe Cys Gln Glu His Asp Ile Leu Val Glu Ala Tyr Ser 
        195                 200                 205             
Pro Leu Gly Pro Leu Gln Lys Lys Thr Ala Gln Asp Asp Ser Gln Pro 
    210                 215                 220                 
Phe Phe Glu Tyr Val Lys Glu Leu Ser Glu Lys Tyr Ile Lys Ser Glu 
225                 230                 235                 240 
Ala Gln Ile Ile Leu Arg Trp Val Thr Lys Arg Gly Val Leu Pro Val 
                245                 250                 255     
Thr Thr Ser Ser Lys Pro Gln Arg Ile Ser Asp Ala Gln Asn Leu Phe 
            260                 265                 270         
Ser Phe Asp Leu Thr Ala Glu Glu Val Asp Lys Ile Thr Glu Leu Gly 
        275                 280                 285             
Leu Glu His Glu Pro Leu Arg Leu Tyr Trp Asn Lys Leu Tyr Gly Lys 
    290                 295                 300                 
Tyr Asn Tyr Ala Ala Gln Lys Val                                 
305                 310                                         


<210> 123
<211> 1047
<212> DNA
<213> Artificial Sequence

<220>
<223> ADH from Rhodococcus erythropolis

<400> 123
atgaaagcca ttcagtacac tcgtatcggt gcggaaccag aactgactga aatcccgaag 60
ccggaaccgg gcccgggcga agtactgctg gaagtcacgg cagctggcgt gtgccattcc 120
gatgatttca ttatgtctct gccggaagaa cagtacacct acggcctgcc gctgaccctg 180
ggtcatgaag gtgctggtaa agttgccgca gttggcgaag gtgttgaagg gttggatatt 240
ggcaccaatg tggttgtgta cggcccatgg ggttgtggca actgttggca ttgcagtcag 300
ggcctggaga actattgctc ccgtgcgcag gaactgggta ttaacccgcc tggtctgggt 360
gctccggggg ctttggcaga atttatgatt gtcgactcac cacgtcattt ggtcccgatt 420
ggcgatttag accctgttaa aactgttccg ttgactgatg cgggcctgac cccataccat 480
gcaatcaaac gctccctgcc gaaactgcgc ggcggctctt atgcagtagt gatcggtacg 540
ggtggcctgg gccacgtggc tatccaactg ctgcgtcatt tatctgctgc aacggtgatc 600
gccttggacg tttctgccga taaactggaa ctggctacca aagtcggcgc acatgaagta 660
gtcctgtctg ataaagatgc agcggagaat gtgcgtaaaa ttactggtag ccaaggtgca 720
gctttggtgt tggattttgt gggctatcag cctaccattg acaccgccat ggcagtggcg 780
ggcgtgggct ctgacgtcac cattgttggt atcggtgatg gccaggcaca tgcgaaagtt 840
ggtttcttcc agagtcctta tgaggcatcg gttacggtac cttattgggg cgctcgtaat 900
gaactgatcg aattgatcga tctggcgcat gctggtattt tcgacattgc cgttgagacc 960
ttctctttgg ataatggtgc agaggcctat cgtcgcctgg ctgcgggcac actgtcaggc 1020
cgtgcggtag tcgtcccggg cctgtaa                                     1047


<210> 124
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<223> ADH from Rhodococcus erythropolis

<400> 124
Met Lys Ala Ile Gln Tyr Thr Arg Ile Gly Ala Glu Pro Glu Leu Thr 
1               5                   10                  15      
Glu Ile Pro Lys Pro Glu Pro Gly Pro Gly Glu Val Leu Leu Glu Val 
            20                  25                  30          
Thr Ala Ala Gly Val Cys His Ser Asp Asp Phe Ile Met Ser Leu Pro 
        35                  40                  45              
Glu Glu Gln Tyr Thr Tyr Gly Leu Pro Leu Thr Leu Gly His Glu Gly 
    50                  55                  60                  
Ala Gly Lys Val Ala Ala Val Gly Glu Gly Val Glu Gly Leu Asp Ile 
65                  70                  75                  80  
Gly Thr Asn Val Val Val Tyr Gly Pro Trp Gly Cys Gly Asn Cys Trp 
                85                  90                  95      
His Cys Ser Gln Gly Leu Glu Asn Tyr Cys Ser Arg Ala Gln Glu Leu 
            100                 105                 110         
Gly Ile Asn Pro Pro Gly Leu Gly Ala Pro Gly Ala Leu Ala Glu Phe 
        115                 120                 125             
Met Ile Val Asp Ser Pro Arg His Leu Val Pro Ile Gly Asp Leu Asp 
    130                 135                 140                 
Pro Val Lys Thr Val Pro Leu Thr Asp Ala Gly Leu Thr Pro Tyr His 
145                 150                 155                 160 
Ala Ile Lys Arg Ser Leu Pro Lys Leu Arg Gly Gly Ser Tyr Ala Val 
                165                 170                 175     
Val Ile Gly Thr Gly Gly Leu Gly His Val Ala Ile Gln Leu Leu Arg 
            180                 185                 190         
His Leu Ser Ala Ala Thr Val Ile Ala Leu Asp Val Ser Ala Asp Lys 
        195                 200                 205             
Leu Glu Leu Ala Thr Lys Val Gly Ala His Glu Val Val Leu Ser Asp 
    210                 215                 220                 
Lys Asp Ala Ala Glu Asn Val Arg Lys Ile Thr Gly Ser Gln Gly Ala 
225                 230                 235                 240 
Ala Leu Val Leu Asp Phe Val Gly Tyr Gln Pro Thr Ile Asp Thr Ala 
                245                 250                 255     
Met Ala Val Ala Gly Val Gly Ser Asp Val Thr Ile Val Gly Ile Gly 
            260                 265                 270         
Asp Gly Gln Ala His Ala Lys Val Gly Phe Phe Gln Ser Pro Tyr Glu 
        275                 280                 285             
Ala Ser Val Thr Val Pro Tyr Trp Gly Ala Arg Asn Glu Leu Ile Glu 
    290                 295                 300                 
Leu Ile Asp Leu Ala His Ala Gly Ile Phe Asp Ile Ala Val Glu Thr 
305                 310                 315                 320 
Phe Ser Leu Asp Asn Gly Ala Glu Ala Tyr Arg Arg Leu Ala Ala Gly 
                325                 330                 335     
Thr Leu Ser Gly Arg Ala Val Val Val Pro Gly Leu                 
            340                 345                             


<210> 125
<211> 1047
<212> DNA
<213> Artificial Sequence

<220>
<223> YGL ADH from Saccharomyces cervisiae

<400> 125
atgaccacgg aaaaaaccgt agtgttcgtg tcaggcgcga ccggttttat tgctctgcac 60
gtggtagatg acctgctgaa aactggttac aaagtaattg gttccggtcg ttctcaggaa 120
aaaaatgacg gtttgctgaa gaagttcaag tccaacccga atctgagcat ggaaattgtg 180
gaagatattg cggcaccaaa cgccttcgat aaagtattcc agaaacatgg taaagaaatt 240
aaagtggtcc tgcatatcgc gtccccggtc catttcaaca ctaccgattt cgaaaaagac 300
ttactgatcc cggcggtaaa cggtaccaaa tctattttgg aagcaattaa gaactatgcc 360
gcagacaccg tggaaaaagt ggttattact tcatctgttg ccgcgttggc ctctccgggt 420
gatatgaaag ataccagctt cgtggttaac gaagaatcct ggaataaaga cacctgggaa 480
tcgtgtcagg cgaatgctgt gtccgcttat tgcggttcta aaaaattcgc agagaaaacg 540
gcgtgggact tcttggaaga aaaccagagc agcattaaat ttactctgtc cacgattaac 600
ccaggcttcg tttttggtcc gcagctgttc gccgactcct tgcgcaatgg tattaactct 660
agcagtgcga ttattgcgaa cctggtgtcg tataaattag gggataactt ctacaattat 720
agcggcccgt ttatcgacgt ccgtgacgtt tccaaagctc atctgctggc atttgagaaa 780
cctgaatgcg ccggtcagcg cctgtttctg tgcgaggata tgttctgttc ccaggaagcc 840
ctggacattc tgaacgaaga atttccacag ctgaagggca agatcgcaac gggcgaacct 900
ggcagcggct cgaccttcct gactaaaaat tgttgcaaat gcgacaatcg taaaactaaa 960
aacttgctgg gcttccagtt caacaaattc cgcgactgca ttgtcgatac tgcgtcccag 1020
ttgctggaag tgcaaagcaa aagctaa                                     1047


<210> 126
<211> 348
<212> PRT
<213> Artificial Sequence

<220>
<223> YGL ADH from Saccharomyces cervisiae

<400> 126
Met Thr Thr Glu Lys Thr Val Val Phe Val Ser Gly Ala Thr Gly Phe 
1               5                   10                  15      
Ile Ala Leu His Val Val Asp Asp Leu Leu Lys Thr Gly Tyr Lys Val 
            20                  25                  30          
Ile Gly Ser Gly Arg Ser Gln Glu Lys Asn Asp Gly Leu Leu Lys Lys 
        35                  40                  45              
Phe Lys Ser Asn Pro Asn Leu Ser Met Glu Ile Val Glu Asp Ile Ala 
    50                  55                  60                  
Ala Pro Asn Ala Phe Asp Lys Val Phe Gln Lys His Gly Lys Glu Ile 
65                  70                  75                  80  
Lys Val Val Leu His Ile Ala Ser Pro Val His Phe Asn Thr Thr Asp 
                85                  90                  95      
Phe Glu Lys Asp Leu Leu Ile Pro Ala Val Asn Gly Thr Lys Ser Ile 
            100                 105                 110         
Leu Glu Ala Ile Lys Asn Tyr Ala Ala Asp Thr Val Glu Lys Val Val 
        115                 120                 125             
Ile Thr Ser Ser Val Ala Ala Leu Ala Ser Pro Gly Asp Met Lys Asp 
    130                 135                 140                 
Thr Ser Phe Val Val Asn Glu Glu Ser Trp Asn Lys Asp Thr Trp Glu 
145                 150                 155                 160 
Ser Cys Gln Ala Asn Ala Val Ser Ala Tyr Cys Gly Ser Lys Lys Phe 
                165                 170                 175     
Ala Glu Lys Thr Ala Trp Asp Phe Leu Glu Glu Asn Gln Ser Ser Ile 
            180                 185                 190         
Lys Phe Thr Leu Ser Thr Ile Asn Pro Gly Phe Val Phe Gly Pro Gln 
        195                 200                 205             
Leu Phe Ala Asp Ser Leu Arg Asn Gly Ile Asn Ser Ser Ser Ala Ile 
    210                 215                 220                 
Ile Ala Asn Leu Val Ser Tyr Lys Leu Gly Asp Asn Phe Tyr Asn Tyr 
225                 230                 235                 240 
Ser Gly Pro Phe Ile Asp Val Arg Asp Val Ser Lys Ala His Leu Leu 
                245                 250                 255     
Ala Phe Glu Lys Pro Glu Cys Ala Gly Gln Arg Leu Phe Leu Cys Glu 
            260                 265                 270         
Asp Met Phe Cys Ser Gln Glu Ala Leu Asp Ile Leu Asn Glu Glu Phe 
        275                 280                 285             
Pro Gln Leu Lys Gly Lys Ile Ala Thr Gly Glu Pro Gly Ser Gly Ser 
    290                 295                 300                 
Thr Phe Leu Thr Lys Asn Cys Cys Lys Cys Asp Asn Arg Lys Thr Lys 
305                 310                 315                 320 
Asn Leu Leu Gly Phe Gln Phe Asn Lys Phe Arg Asp Cys Ile Val Asp 
                325                 330                 335     
Thr Ala Ser Gln Leu Leu Glu Val Gln Ser Lys Ser                 
            340                 345                             


<210> 127
<211> 939
<212> DNA
<213> Artificial Sequence

<220>
<223> YPR ADH from Saccharomyces cervisiae

<400> 127
atgccggcaa cgttaaaaaa cagcagtgct accttaaaat taaacacagg tgcgagcatt 60
cctgtcctgg ggttcggcac ctggcgctct gtcgataaca acggctatca tagtgtaatt 120
gcggcgctga aagcggggta ccgtcatatc gatgctgcgg ccatctatct gaatgaagaa 180
gaagtcggcc gtgcgatcaa ggactccggt gttcctcgtg aagaaatttt tattaccacc 240
aaactgtggg gcaccgaaca acgcgatcca gaagcagccc tgaacaaatc tctgaaacgt 300
ctgggtctgg actatgtgga cctgtatctg atgcactggc cggtccctct gaaaacagac 360
cgtgtaactg acggtaacgt cctgtgcatc ccgaccctgg aagatggcac cgtggacatc 420
gataccaaag agtggaattt tattaaaacc tgggaactga tgcaggaatt gccgaaaact 480
ggtaagacca aagccgtcgg tgtgtccaat ttttccatca acaatatcaa agaactgctg 540
gaatcgccaa ataacaaggt cgttccagca accaatcaga tcgagattca tccgttgctg 600
ccgcaggatg aattaatcgc cttttgtaaa gaaaaaggca ttgtggtcga agcatatagc 660
ccattcggct ccgctaacgc cccgctgctg aaagaacagg cgattatcga tatggccaaa 720
aagcacggcg tcgaaccggc gcaactgatt atcagctggt cgattcagcg cggttatgtg 780
gtattggcca agtccgtaaa tccggagcgt atcgtgtcga actttaagat ttttaccctg 840
ccagaggatg atttcaaaac catctctaac ctgagcaaag tgcacggtac caaacgtgtc 900
gttgacatga aatggggctc atttccgatt tttcaataa                        939


<210> 128
<211> 312
<212> PRT
<213> Artificial Sequence

<220>
<223> YPR ADH from Saccharomyces cervisiae

<400> 128
Met Pro Ala Thr Leu Lys Asn Ser Ser Ala Thr Leu Lys Leu Asn Thr 
1               5                   10                  15      
Gly Ala Ser Ile Pro Val Leu Gly Phe Gly Thr Trp Arg Ser Val Asp 
            20                  25                  30          
Asn Asn Gly Tyr His Ser Val Ile Ala Ala Leu Lys Ala Gly Tyr Arg 
        35                  40                  45              
His Ile Asp Ala Ala Ala Ile Tyr Leu Asn Glu Glu Glu Val Gly Arg 
    50                  55                  60                  
Ala Ile Lys Asp Ser Gly Val Pro Arg Glu Glu Ile Phe Ile Thr Thr 
65                  70                  75                  80  
Lys Leu Trp Gly Thr Glu Gln Arg Asp Pro Glu Ala Ala Leu Asn Lys 
                85                  90                  95      
Ser Leu Lys Arg Leu Gly Leu Asp Tyr Val Asp Leu Tyr Leu Met His 
            100                 105                 110         
Trp Pro Val Pro Leu Lys Thr Asp Arg Val Thr Asp Gly Asn Val Leu 
        115                 120                 125             
Cys Ile Pro Thr Leu Glu Asp Gly Thr Val Asp Ile Asp Thr Lys Glu 
    130                 135                 140                 
Trp Asn Phe Ile Lys Thr Trp Glu Leu Met Gln Glu Leu Pro Lys Thr 
145                 150                 155                 160 
Gly Lys Thr Lys Ala Val Gly Val Ser Asn Phe Ser Ile Asn Asn Ile 
                165                 170                 175     
Lys Glu Leu Leu Glu Ser Pro Asn Asn Lys Val Val Pro Ala Thr Asn 
            180                 185                 190         
Gln Ile Glu Ile His Pro Leu Leu Pro Gln Asp Glu Leu Ile Ala Phe 
        195                 200                 205             
Cys Lys Glu Lys Gly Ile Val Val Glu Ala Tyr Ser Pro Phe Gly Ser 
    210                 215                 220                 
Ala Asn Ala Pro Leu Leu Lys Glu Gln Ala Ile Ile Asp Met Ala Lys 
225                 230                 235                 240 
Lys His Gly Val Glu Pro Ala Gln Leu Ile Ile Ser Trp Ser Ile Gln 
                245                 250                 255     
Arg Gly Tyr Val Val Leu Ala Lys Ser Val Asn Pro Glu Arg Ile Val 
            260                 265                 270         
Ser Asn Phe Lys Ile Phe Thr Leu Pro Glu Asp Asp Phe Lys Thr Ile 
        275                 280                 285             
Ser Asn Leu Ser Lys Val His Gly Thr Lys Arg Val Val Asp Met Lys 
    290                 295                 300                 
Trp Gly Ser Phe Pro Ile Phe Gln                                 
305                 310                                         


<210> 129
<211> 1029
<212> DNA
<213> Artificial Sequence

<220>
<223> GRE ADH from Saccharomyces cervisiae

<400> 129
atgtctgtgt tcgtgtcagg cgcgaatggt tttattgctc agcacatcgt agatctgctg 60
ctgaaagaag attacaaagt aattggttcc gcacgttctc aggaaaaagc tgaaaatttg 120
accgaagcct tcggtaacaa cccgaaattt agcatggaag tggtgcctga tattagcaaa 180
ctggatgcct tcgatcatgt attccagaaa catggtaaag atattaaaat cgtcctgcat 240
accgcgtccc cgttttgttt cgatattacc gattccgaac gtgacttact gatcccggcg 300
gtaaacggtg tcaaaggtat tttgcacagt attaagaaat atgccgcaga cagcgtggaa 360
cgcgtggttc tgacttcatc ttacgccgcg gtatttgata tggcgaagga aaacgataag 420
agcctgacct tcaacgaaga atcctggaat ccggcgacct gggaatcgtg tcagagtgat 480
ccggtgaacg cttattgcgg ttctaaaaaa ttcgcagaga aagcagcgtg ggaattcttg 540
gaagaaaacc gtgatagcgt gaaatttgag ctgacagcgg tcaacccagt ttacgttttt 600
ggtccgcaga tgttcgataa agatgttaaa aaacacttga acaccagctg cgaactggtg 660
aactctctga tgcatctgag ccctgaagat aaaattccgg aactgtttgg cggttacatc 720
gacgtccgtg acgttgcgaa agctcatctg gttgcatttc agaaacgtga aacaatcggt 780
cagcgcctga tcgtgtcgga ggcacgtttc acgatgcagg acgttctgga cattctgaac 840
gaagactttc cagtactgaa gggcaatatc ccggtcggca agcctggcag cggcgccacc 900
cataatactc tgggcgccac cctggacaat aaaaaaagca aaaaattgct gggcttcaaa 960
ttccgtaatc tgaaagagac tattgacgat actgcgtccc agatcctgaa attcgaaggt 1020
cgcatttaa                                                         1029


<210> 130
<211> 342
<212> PRT
<213> Artificial Sequence

<220>
<223> GRE ADH from Saccharomyces cervisiae

<400> 130
Met Ser Val Phe Val Ser Gly Ala Asn Gly Phe Ile Ala Gln His Ile 
1               5                   10                  15      
Val Asp Leu Leu Leu Lys Glu Asp Tyr Lys Val Ile Gly Ser Ala Arg 
            20                  25                  30          
Ser Gln Glu Lys Ala Glu Asn Leu Thr Glu Ala Phe Gly Asn Asn Pro 
        35                  40                  45              
Lys Phe Ser Met Glu Val Val Pro Asp Ile Ser Lys Leu Asp Ala Phe 
    50                  55                  60                  
Asp His Val Phe Gln Lys His Gly Lys Asp Ile Lys Ile Val Leu His 
65                  70                  75                  80  
Thr Ala Ser Pro Phe Cys Phe Asp Ile Thr Asp Ser Glu Arg Asp Leu 
                85                  90                  95      
Leu Ile Pro Ala Val Asn Gly Val Lys Gly Ile Leu His Ser Ile Lys 
            100                 105                 110         
Lys Tyr Ala Ala Asp Ser Val Glu Arg Val Val Leu Thr Ser Ser Tyr 
        115                 120                 125             
Ala Ala Val Phe Asp Met Ala Lys Glu Asn Asp Lys Ser Leu Thr Phe 
    130                 135                 140                 
Asn Glu Glu Ser Trp Asn Pro Ala Thr Trp Glu Ser Cys Gln Ser Asp 
145                 150                 155                 160 
Pro Val Asn Ala Tyr Cys Gly Ser Lys Lys Phe Ala Glu Lys Ala Ala 
                165                 170                 175     
Trp Glu Phe Leu Glu Glu Asn Arg Asp Ser Val Lys Phe Glu Leu Thr 
            180                 185                 190         
Ala Val Asn Pro Val Tyr Val Phe Gly Pro Gln Met Phe Asp Lys Asp 
        195                 200                 205             
Val Lys Lys His Leu Asn Thr Ser Cys Glu Leu Val Asn Ser Leu Met 
    210                 215                 220                 
His Leu Ser Pro Glu Asp Lys Ile Pro Glu Leu Phe Gly Gly Tyr Ile 
225                 230                 235                 240 
Asp Val Arg Asp Val Ala Lys Ala His Leu Val Ala Phe Gln Lys Arg 
                245                 250                 255     
Glu Thr Ile Gly Gln Arg Leu Ile Val Ser Glu Ala Arg Phe Thr Met 
            260                 265                 270         
Gln Asp Val Leu Asp Ile Leu Asn Glu Asp Phe Pro Val Leu Lys Gly 
        275                 280                 285             
Asn Ile Pro Val Gly Lys Pro Gly Ser Gly Ala Thr His Asn Thr Leu 
    290                 295                 300                 
Gly Ala Thr Leu Asp Asn Lys Lys Ser Lys Lys Leu Leu Gly Phe Lys 
305                 310                 315                 320 
Phe Arg Asn Leu Lys Glu Thr Ile Asp Asp Thr Ala Ser Gln Ile Leu 
                325                 330                 335     
Lys Phe Glu Gly Arg Ile                                         
            340                                                 


<210> 131
<211> 1032
<212> DNA
<213> Artificial Sequence

<220>
<223> Codon optimized ADH from S. salmonicolor

<400> 131
atggcaaaga tcgacaacgc agttctgccg gagggttctc tggtgctggt caccggcgcg 60
aacggctttg tcgctagcca tgtggtcgaa caactgctgg aacacggcta taaggtgcgc 120
ggcactgctc gctctgcctc caaactggcg aacctgcaga aacgttggga cgccaaatac 180
cctggtcgtt tcgagactgc cgttgttgaa gacatgctga agcagggtgc atatgatgaa 240
gttattaaag gcgcggcagg tgtcgcccac atcgcgtccg tggtcagctt ttctaacaaa 300
tatgatgagg tggtaactcc tgcgatcggt ggcacgctga atgccctgcg tgccgcagct 360
gctacgcctt ccgtgaaacg ttttgtgctg accagcagca ctgtttctgc actgattcca 420
aaacctaacg tcgaaggtat ttatctggat gagaagagct ggaacctgga aagcattgat 480
aaggctaaaa ccctgcctga atctgatccg cagaaaagcc tgtgggtcta cgccgcaagc 540
aaaacggaag cggaactggc tgcctggaaa ttcatggacg aaaacaaacc gcactttact 600
ctgaatgccg ttctgccaaa ctacactatc ggtaccattt ttgacccaga aacccaatcc 660
ggttccactt ccggctggat gatgtctctg ttcaatggcg aagtatctcc ggcactggcg 720
ctgatgccgc cgcagtacta tgtctctgca gttgatatcg gtctgctgca cctgggttgt 780
ctggttctgc cgcaaatcga acgccgtcgt gtttacggca ccgcaggcac ctttgattgg 840
aacaccgttc tggcgacctt ccgtaaactg tatccgtcca agacgttccc ggctgacttt 900
ccggatcagg gccaggatct gtccaaattt gataccgccc cgagcctgga gattctgaaa 960
tccctgggcc gccctggctg gcgtagcatc gaggaatcta tcaaagatct ggtgggttcc 1020
gagaccgcct aa                                                     1032


<210> 132
<211> 343
<212> PRT
<213> Artificial Sequence

<220>
<223> ADH from S. salmonicolor

<400> 132
Met Ala Lys Ile Asp Asn Ala Val Leu Pro Glu Gly Ser Leu Val Leu 
1               5                   10                  15      
Val Thr Gly Ala Asn Gly Phe Val Ala Ser His Val Val Glu Gln Leu 
            20                  25                  30          
Leu Glu His Gly Tyr Lys Val Arg Gly Thr Ala Arg Ser Ala Ser Lys 
        35                  40                  45              
Leu Ala Asn Leu Gln Lys Arg Trp Asp Ala Lys Tyr Pro Gly Arg Phe 
    50                  55                  60                  
Glu Thr Ala Val Val Glu Asp Met Leu Lys Gln Gly Ala Tyr Asp Glu 
65                  70                  75                  80  
Val Ile Lys Gly Ala Ala Gly Val Ala His Ile Ala Ser Val Val Ser 
                85                  90                  95      
Phe Ser Asn Lys Tyr Asp Glu Val Val Thr Pro Ala Ile Gly Gly Thr 
            100                 105                 110         
Leu Asn Ala Leu Arg Ala Ala Ala Ala Thr Pro Ser Val Lys Arg Phe 
        115                 120                 125             
Val Leu Thr Ser Ser Thr Val Ser Ala Leu Ile Pro Lys Pro Asn Val 
    130                 135                 140                 
Glu Gly Ile Tyr Leu Asp Glu Lys Ser Trp Asn Leu Glu Ser Ile Asp 
145                 150                 155                 160 
Lys Ala Lys Thr Leu Pro Glu Ser Asp Pro Gln Lys Ser Leu Trp Val 
                165                 170                 175     
Tyr Ala Ala Ser Lys Thr Glu Ala Glu Leu Ala Ala Trp Lys Phe Met 
            180                 185                 190         
Asp Glu Asn Lys Pro His Phe Thr Leu Asn Ala Val Leu Pro Asn Tyr 
        195                 200                 205             
Thr Ile Gly Thr Ile Phe Asp Pro Glu Thr Gln Ser Gly Ser Thr Ser 
    210                 215                 220                 
Gly Trp Met Met Ser Leu Phe Asn Gly Glu Val Ser Pro Ala Leu Ala 
225                 230                 235                 240 
Leu Met Pro Pro Gln Tyr Tyr Val Ser Ala Val Asp Ile Gly Leu Leu 
                245                 250                 255     
His Leu Gly Cys Leu Val Leu Pro Gln Ile Glu Arg Arg Arg Val Tyr 
            260                 265                 270         
Gly Thr Ala Gly Thr Phe Asp Trp Asn Thr Val Leu Ala Thr Phe Arg 
        275                 280                 285             
Lys Leu Tyr Pro Ser Lys Thr Phe Pro Ala Asp Phe Pro Asp Gln Gly 
    290                 295                 300                 
Gln Asp Leu Ser Lys Phe Asp Thr Ala Pro Ser Leu Glu Ile Leu Lys 
305                 310                 315                 320 
Ser Leu Gly Arg Pro Gly Trp Arg Ser Ile Glu Glu Ser Ile Lys Asp 
                325                 330                 335     
Leu Val Gly Ser Glu Thr Ala                                     
            340                                                 


<210> 133
<211> 1041
<212> DNA
<213> Artificial Sequence

<220>
<223> Codon optimized ADH from S. coelicolor

<400> 133
atgaaggcac tgcagtaccg caccatcggc gccccgcccg aggtcgtcac cgtcccggac 60
ccggagccgg gccccggcca ggtgctgttg aaggtgaccg cggccggagt ctgccactcc 120
gacatcgcgg tgatgagctg gcccgccgag ggcttcccgt acgagctgcc gctcaccctc 180
ggccacgagg gcgtcggcac cgtggccgcg ctcggcgccg gggtgacggg gctcgccgag 240
ggcgacgcgg tcgccgtgta cgggccctgg ggctgcggca cctgcgccaa gtgcgcggag 300
ggcaaggaga actactgcct gcgcgccgac gagctgggca tccgtccgcc ggggctcggg 360
cgtccggggt ccatggccga gtacctgctg atcgacgacc cccggcacct ggtcccgctg 420
gacgggctcg acccggtcgc ggcggtgccg ctcaccgacg ccggactgac gccgtaccac 480
gcgatcaagc ggtcgctgcc caagctggtc cccggctcca ccgcggtggt catcggcacc 540
ggtggtctcg gccacgtcgc catccagctg ctgcgcgccc tgacgtccgc ccgggtggtc 600
gccctggacg tcagcgagga gaagctgcgc ctcgcccgtg cggtgggcgc gcacgaggcg 660
gtgctgtcgg acgcgaaggc cgcggacgcg gtgcgcgaga tcaccggcgg tctcggtgcc 720
gaggccgtgt tcgacttcgt cggcgtggcg cccaccgtgc agaccgccgg agccgtcgcg 780
gccgtcgagg gcgatgtcac cctggtcggc atcggcggcg gatcgctgcc cgtcggcttc 840
ggcatgctgc cgttcgaggt gtcggtcaac gccccctact ggggcagccg cagcgagctg 900
accgaggtgc tgaacctggc ccgctccggt gccgtgtcgg tgcacaccga gacgtactcc 960
ctggacgacg ccccgctcgc ctacgagcgg ctgcacgagg gcagggtcaa cggccgcgcg 1020
gtgatcctgc cccacggctg a                                           1041


<210> 134
<211> 346
<212> PRT
<213> Artificial Sequence

<220>
<223> ADH from S. coelicolor

<400> 134
Met Lys Ala Leu Gln Tyr Arg Thr Ile Gly Ala Pro Pro Glu Val Val 
1               5                   10                  15      
Thr Val Pro Asp Pro Glu Pro Gly Pro Gly Gln Val Leu Leu Lys Val 
            20                  25                  30          
Thr Ala Ala Gly Val Cys His Ser Asp Ile Ala Val Met Ser Trp Pro 
        35                  40                  45              
Ala Glu Gly Phe Pro Tyr Glu Leu Pro Leu Thr Leu Gly His Glu Gly 
    50                  55                  60                  
Val Gly Thr Val Ala Ala Leu Gly Ala Gly Val Thr Gly Leu Ala Glu 
65                  70                  75                  80  
Gly Asp Ala Val Ala Val Tyr Gly Pro Trp Gly Cys Gly Thr Cys Ala 
                85                  90                  95      
Lys Cys Ala Glu Gly Lys Glu Asn Tyr Cys Leu Arg Ala Asp Glu Leu 
            100                 105                 110         
Gly Ile Arg Pro Pro Gly Leu Gly Arg Pro Gly Ser Met Ala Glu Tyr 
        115                 120                 125             
Leu Leu Ile Asp Asp Pro Arg His Leu Val Pro Leu Asp Gly Leu Asp 
    130                 135                 140                 
Pro Val Ala Ala Val Pro Leu Thr Asp Ala Gly Leu Thr Pro Tyr His 
145                 150                 155                 160 
Ala Ile Lys Arg Ser Leu Pro Lys Leu Val Pro Gly Ser Thr Ala Val 
                165                 170                 175     
Val Ile Gly Thr Gly Gly Leu Gly His Val Ala Ile Gln Leu Leu Arg 
            180                 185                 190         
Ala Leu Thr Ser Ala Arg Val Val Ala Leu Asp Val Ser Glu Glu Lys 
        195                 200                 205             
Leu Arg Leu Ala Arg Ala Val Gly Ala His Glu Ala Val Leu Ser Asp 
    210                 215                 220                 
Ala Lys Ala Ala Asp Ala Val Arg Glu Ile Thr Gly Gly Leu Gly Ala 
225                 230                 235                 240 
Glu Ala Val Phe Asp Phe Val Gly Val Ala Pro Thr Val Gln Thr Ala 
                245                 250                 255     
Gly Ala Val Ala Ala Val Glu Gly Asp Val Thr Leu Val Gly Ile Gly 
            260                 265                 270         
Gly Gly Ser Leu Pro Val Gly Phe Gly Met Leu Pro Phe Glu Val Ser 
        275                 280                 285             
Val Asn Ala Pro Tyr Trp Gly Ser Arg Ser Glu Leu Thr Glu Val Leu 
    290                 295                 300                 
Asn Leu Ala Arg Ser Gly Ala Val Ser Val His Thr Glu Thr Tyr Ser 
305                 310                 315                 320 
Leu Asp Asp Ala Pro Leu Ala Tyr Glu Arg Leu His Glu Gly Arg Val 
                325                 330                 335     
Asn Gly Arg Ala Val Ile Leu Pro His Gly                         
            340                 345                             


<210> 135
<211> 1056
<212> DNA
<213> Artificial Sequence

<220>
<223> Codon optimized ADH-TB from T brockii

<400> 135
atgaaaggct tcgccatgct gagcatcggc aaagtgggtt ggattgaaaa agaaaaaccg 60
gcgccaggcc cgttcgatgc aattgtgcgc cctctggcag tagcgccgtg taccagcgat 120
attcatactg tgtttgaagg tgccattggc gagcgtcaca atatgattct gggccatgaa 180
gccgttggtg aagttgttga ggttggcagc gaagtgaagg atttcaaacc gggcgatcgc 240
gttgtcgttc cagcgattac cccggattgg cgcaccagcg aagtccagcg cggctaccat 300
cagcactctg gcggcatgct ggccggctgg aaattcagca atgtaaagga tggtgtgttc 360
ggtgaatttt ttcacgttaa cgacgcagac atgaatctgg cgcacctgcc gaaagaaatc 420
ccgctggaag cagcggttat gattccggat atgatgacca cgggttttca cggcgcagag 480
ctggcggaca ttgaactggg cgctacggta gccgtactgg gcatcggtcc ggtgggcctg 540
atggcagttg caggcgctaa gctgcgcggc gcaggtcgta ttattgccgt tggttctcgc 600
ccggtgtgtg tggacgccgc taagtattat ggtgcaacgg acattgtcaa ttacaaggac 660
ggcccaattg aatctcagat catgaacctg acggaaggta aaggcgttga cgccgcgatt 720
atcgctggcg gcaacgccga catcatggcg accgcagtta aaatcgtcaa gccaggtggt 780
actattgcta acgtcaacta cttcggcgaa ggtgaggtcc tgcctgtccc acgtctggaa 840
tggggttgcg gtatggcaca taaaaccatt aaaggtggcc tgtgcccagg cggccgtctg 900
cgtatggaac gcctgatcga tctggtcttc tacaaacgcg tggatcctag caaactggtg 960
actcacgttt tccgcggctt tgataacatc gaaaaagctt ttatgctgat gaaagataaa 1020
ccgaaagatc tgattaaacc ggttgtcatc ctggct                           1056


<210> 136
<211> 352
<212> PRT
<213> Artificial Sequence

<220>
<223> ADH-TB from T brockii

<400> 136
Met Lys Gly Phe Ala Met Leu Ser Ile Gly Lys Val Gly Trp Ile Glu 
1               5                   10                  15      
Lys Glu Lys Pro Ala Pro Gly Pro Phe Asp Ala Ile Val Arg Pro Leu 
            20                  25                  30          
Ala Val Ala Pro Cys Thr Ser Asp Ile His Thr Val Phe Glu Gly Ala 
        35                  40                  45              
Ile Gly Glu Arg His Asn Met Ile Leu Gly His Glu Ala Val Gly Glu 
    50                  55                  60                  
Val Val Glu Val Gly Ser Glu Val Lys Asp Phe Lys Pro Gly Asp Arg 
65                  70                  75                  80  
Val Val Val Pro Ala Ile Thr Pro Asp Trp Arg Thr Ser Glu Val Gln 
                85                  90                  95      
Arg Gly Tyr His Gln His Ser Gly Gly Met Leu Ala Gly Trp Lys Phe 
            100                 105                 110         
Ser Asn Val Lys Asp Gly Val Phe Gly Glu Phe Phe His Val Asn Asp 
        115                 120                 125             
Ala Asp Met Asn Leu Ala His Leu Pro Lys Glu Ile Pro Leu Glu Ala 
    130                 135                 140                 
Ala Val Met Ile Pro Asp Met Met Thr Thr Gly Phe His Gly Ala Glu 
145                 150                 155                 160 
Leu Ala Asp Ile Glu Leu Gly Ala Thr Val Ala Val Leu Gly Ile Gly 
                165                 170                 175     
Pro Val Gly Leu Met Ala Val Ala Gly Ala Lys Leu Arg Gly Ala Gly 
            180                 185                 190         
Arg Ile Ile Ala Val Gly Ser Arg Pro Val Cys Val Asp Ala Ala Lys 
        195                 200                 205             
Tyr Tyr Gly Ala Thr Asp Ile Val Asn Tyr Lys Asp Gly Pro Ile Glu 
    210                 215                 220                 
Ser Gln Ile Met Asn Leu Thr Glu Gly Lys Gly Val Asp Ala Ala Ile 
225                 230                 235                 240 
Ile Ala Gly Gly Asn Ala Asp Ile Met Ala Thr Ala Val Lys Ile Val 
                245                 250                 255     
Lys Pro Gly Gly Thr Ile Ala Asn Val Asn Tyr Phe Gly Glu Gly Glu 
            260                 265                 270         
Val Leu Pro Val Pro Arg Leu Glu Trp Gly Cys Gly Met Ala His Lys 
        275                 280                 285             
Thr Ile Lys Gly Gly Leu Cys Pro Gly Gly Arg Leu Arg Met Glu Arg 
    290                 295                 300                 
Leu Ile Asp Leu Val Phe Tyr Lys Arg Val Asp Pro Ser Lys Leu Val 
305                 310                 315                 320 
Thr His Val Phe Arg Gly Phe Asp Asn Ile Glu Lys Ala Phe Met Leu 
                325                 330                 335     
Met Lys Asp Lys Pro Lys Asp Leu Ile Lys Pro Val Val Ile Leu Ala 
            340                 345                 350         


<210> 137
<211> 1125
<212> DNA
<213> Artificial Sequence

<220>
<223> Codon optimized ADH from Horse Liver, E form  

<400> 137
atgagcacag cagggaaagt aattaaatgc aaagcagctg tgctgtggga ggaaaagaaa 60
ccattttcca ttgaggaggt ggaggtcgca cctccgaagg cccatgaagt ccgtattaag 120
atggtggcca cagggatctg tcgctcagat gaccacgtgg ttagtgggac cctggtcaca 180
cctctgcctg tgatcgcagg ccatgaggca gctggcattg tggagagcat cggggaaggc 240
gtcactacag tacgtccagg tgataaagtc atcccactgt ttactcctca gtgtgggaaa 300
tgccgtgttt gtaaacaccc tgaaggcaac ttctgcttga aaaatgatct gagcatgcct 360
cgtgggacca tgcaggatgg taccagccgt ttcacctgcc gtgggaagcc tatccaccac 420
ttcctgggca ccagcacctt ctcccagtac accgtggtgg acgagatctc agtggccaag 480
atcgatgcgg cctcaccgct ggagaaagtc tgtctgattg gctgtgggtt ttctactggt 540
tatgggtctg cagtcaaggt tgccaaggtc acccagggct ccacctgtgc cgtgtttggc 600
ctgggggggg tgggcctgtc tgttatcatg ggctgtaaag cagccggggc ggcccgtatc 660
attggggtgg acatcaacaa agacaagttt gcaaaggcca aagaagtggg tgccactgag 720
tgtgtcaacc ctcaggacta caagaaacct atccaggagg tgctgacaga aatgagcaat 780
gggggcgtgg atttttcatt tgaagtcatt ggtcgtctgg acaccatggt gactgccttg 840
tcatgctgtc aagaagcata tggtgtgagc gtcatcgtag gggtacctcc tgattcccaa 900
aatctgtcta tgaatcctat gttgctgctg agtgggcgta cctggaaagg ggctattttt 960
ggtggtttta agagtaaaga ttctgtccct aaactggtgg ccgattttat ggctaaaaag 1020
tttgcactgg atcctttaat cacccatgtt ttaccttttg aaaaaattaa tgaagggttt 1080
gacctgctgc gctctgggga gagtatccgt accatcctga cgttt                 1125


<210> 138
<211> 375
<212> PRT
<213> Artificial Sequence

<220>
<223> ADH from Horse Liver, E form

<400> 138
Met Ser Thr Ala Gly Lys Val Ile Lys Cys Lys Ala Ala Val Leu Trp 
1               5                   10                  15      
Glu Glu Lys Lys Pro Phe Ser Ile Glu Glu Val Glu Val Ala Pro Pro 
            20                  25                  30          
Lys Ala His Glu Val Arg Ile Lys Met Val Ala Thr Gly Ile Cys Arg 
        35                  40                  45              
Ser Asp Asp His Val Val Ser Gly Thr Leu Val Thr Pro Leu Pro Val 
    50                  55                  60                  
Ile Ala Gly His Glu Ala Ala Gly Ile Val Glu Ser Ile Gly Glu Gly 
65                  70                  75                  80  
Val Thr Thr Val Arg Pro Gly Asp Lys Val Ile Pro Leu Phe Thr Pro 
                85                  90                  95      
Gln Cys Gly Lys Cys Arg Val Cys Lys His Pro Glu Gly Asn Phe Cys 
            100                 105                 110         
Leu Lys Asn Asp Leu Ser Met Pro Arg Gly Thr Met Gln Asp Gly Thr 
        115                 120                 125             
Ser Arg Phe Thr Cys Arg Gly Lys Pro Ile His His Phe Leu Gly Thr 
    130                 135                 140                 
Ser Thr Phe Ser Gln Tyr Thr Val Val Asp Glu Ile Ser Val Ala Lys 
145                 150                 155                 160 
Ile Asp Ala Ala Ser Pro Leu Glu Lys Val Cys Leu Ile Gly Cys Gly 
                165                 170                 175     
Phe Ser Thr Gly Tyr Gly Ser Ala Val Lys Val Ala Lys Val Thr Gln 
            180                 185                 190         
Gly Ser Thr Cys Ala Val Phe Gly Leu Gly Gly Val Gly Leu Ser Val 
        195                 200                 205             
Ile Met Gly Cys Lys Ala Ala Gly Ala Ala Arg Ile Ile Gly Val Asp 
    210                 215                 220                 
Ile Asn Lys Asp Lys Phe Ala Lys Ala Lys Glu Val Gly Ala Thr Glu 
225                 230                 235                 240 
Cys Val Asn Pro Gln Asp Tyr Lys Lys Pro Ile Gln Glu Val Leu Thr 
                245                 250                 255     
Glu Met Ser Asn Gly Gly Val Asp Phe Ser Phe Glu Val Ile Gly Arg 
            260                 265                 270         
Leu Asp Thr Met Val Thr Ala Leu Ser Cys Cys Gln Glu Ala Tyr Gly 
        275                 280                 285             
Val Ser Val Ile Val Gly Val Pro Pro Asp Ser Gln Asn Leu Ser Met 
    290                 295                 300                 
Asn Pro Met Leu Leu Leu Ser Gly Arg Thr Trp Lys Gly Ala Ile Phe 
305                 310                 315                 320 
Gly Gly Phe Lys Ser Lys Asp Ser Val Pro Lys Leu Val Ala Asp Phe 
                325                 330                 335     
Met Ala Lys Lys Phe Ala Leu Asp Pro Leu Ile Thr His Val Leu Pro 
            340                 345                 350         
Phe Glu Lys Ile Asn Glu Gly Phe Asp Leu Leu Arg Ser Gly Glu Ser 
        355                 360                 365             
Ile Arg Thr Ile Leu Thr Phe                                     
    370                 375                                     


<210> 139
<211> 252
<212> PRT
<213> Artificial Sequence


<220>
<223> Engineered Ketoreductase Sequence Formula with L. minor backbone
<223> Synthetic Construct

<220>
<221> MISC_FEATURE
<222>(7)..(7)
<223> Xaa is a constrained or non-polar residue

<220>
<221> MISC_FEATURE
<222>(17)..(17)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(25)..(25)
<223> Xaa is a polar or acidic residue

<220>
<221> MISC_FEATURE
<222>(27)..(27)
<223> Xaa is an aromatic residue

<220>
<221> MISC_FEATURE
<222>(41)..(41)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(53)..(53)
<223> Xaa is a polar, non-polar, or acidic residue

<220>
<221> MISC_FEATURE
<222>(57)..(57)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(64)..(64)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(66)..(66)
<223> Xaa is an acidic residue

<220>
<221> MISC_FEATURE
<222>(68)..(68)
<223> Xaa is a polar, acidic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(72)..(72)
<223> Xaa is a basic residue

<220>
<221> MISC_FEATURE
<222>(76)..(76)
<223> Xaa is an aliphatic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(80)..(80)
<223> Xaa is an aliphatic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(93)..(93)
<223> Xaa is is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(94)..(94)
<223> Xaa is a cysteine, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(95)..(95)
<223> Xaa is an aliphatic, non-polar, or acidic residue

<220>
<221> MISC_FEATURE
<222>(96)..(96)
<223> Xaa is is a cyteine, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(97)..(97)
<223> Xaa is a constrained or polar residue

<220>
<221> MISC_FEATURE
<222>(100)..(100)
<223> Xaa is a basic, acidic, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(108)..(108)
<223> Xaa is a basic or constrained residue

<220>
<221> MISC_FEATURE
<222>(111)..(111)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(139)..(139)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(145)..(145)
<223> Xaa is an acidic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(147)..(147)
<223> Xaa is an aromatic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(151)..(151)
<223> Xaa is a constrained, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(152)..(152)
<223> Xaa is a polar, aromatic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(163)..(163)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(165)..(165)
<223> Xaa is a polar, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(173)..(173)
<223> Xaa is an acidic, non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(179)..(179)
<223> Xaa is an aromatic, basic, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(190)..(190)
<223> Xaa is a constrained residue

<220>
<221> MISC_FEATURE
<222>(194)..(194)
<223> Xaa is a constrained, polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(195)..(195)
<223> Xaa is a basic, acidic, non-polar, or polar residue

<220>
<221> MISC_FEATURE
<222>(196)..(196)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(197)..(197)
<223> Xaa is an acidic residue

<220>
<221> MISC_FEATURE
<222>(198)..(198)
<223> Xaa is an acidic or polar residue

<220>
<221> MISC_FEATURE
<222>(202)..(202)
<223> Xaa is an aromatic residue

<220>
<221> MISC_FEATURE
<222>(210)..(210)
<223> Xaa is a polar or basic residue

<220>
<221> MISC_FEATURE
<222>(211)..(211)
<223> Xaa is is a basic, aliphatic, non-polar, acidic, or polar residue

<220>
<221> MISC_FEATURE
<222>(212)..(212)
<223> Xaa is a polar, aliphatic, or non-polar residue

<220>
<221> MISC_FEATURE
<222>(216)..(216)
<223> Xaa is a constrained or basic residue

<220>
<221> MISC_FEATURE
<222>(223)..(223)
<223> Xaa is a non-polar or aliphatic residue

<220>
<221> MISC_FEATURE
<222>(226)..(226)
<223> Xaa is a non-polar or polar residue

<220>
<221> MISC_FEATURE
<222>(233)..(233)
<223> Xaa is a polar or acidic residue


<220>
<221> MISC_FEATURE
<222>(235)..(235)
<223> Xaa is a polar or aromatic residue

<220>
<221> MISC_FEATURE
<222>(248)..(248)
<223> Xaa is a non-polar or aromatic residue

<220>
<221> MISC_FEATURE
<222>(249)..(249)
<223> Xaa is an aromatic residue


<400> 139
Met Thr Asp Arg Leu Lys Xaa Lys Val Ala Ile Val Thr Gly Gly Thr 
1               5                   10                  15      
Leu Gly Ile Gly Leu Ala Ile Ala Asp Lys Phe Val Glu Glu Gly Ala 
            20                  25                  30          
Lys Val Val Ile Thr Gly Arg His Xaa Asp Val Gly Glu Lys Ala Ala 
        35                  40                  45              
Arg Ser Ile Gly Xaa Thr Asp Val Ile Arg Phe Val Gln His Asp Xaa 
    50                  55                  60                  
Ser Asp Glu Xaa Gly Trp Thr Lys Leu Phe Asp Xaa Thr Glu Glu Xaa 
65                  70                  75                  80  
Phe Gly Pro Val Thr Thr Val Val Asn Asn Ala Gly Xaa Xaa Xaa Xaa 
                85                  90                  95      
Xaa Ser Val Xaa Asp Thr Thr Thr Glu Glu Trp Xaa Lys Leu Leu Ser 
            100                 105                 110         
Val Asn Leu Asp Gly Val Phe Phe Gly Thr Arg Leu Gly Ile Gln Arg 
        115                 120                 125             
Met Lys Asn Lys Gly Leu Gly Ala Ser Ile Ile Asn Met Ser Ser Ile 
    130                 135                 140                 
Xaa Gly Xaa Val Gly Asp Pro Xaa Leu Gly Ala Tyr Asn Ala Ser Lys 
145                 150                 155                 160 
Gly Ala Val Arg Ile Met Ser Lys Ser Ala Ala Leu Asp Cys Ala Leu 
                165                 170                 175     
Lys Asp Xaa Asp Val Arg Val Asn Thr Val His Pro Gly Xaa Ile Lys 
            180                 185                 190         
Thr Xaa Xaa Val Asp Xaa Leu Glu Gly Xaa Glu Glu Met Met Ser Gln 
        195                 200                 205             
Arg Xaa Xaa Xaa Pro Met Gly Xaa Ile Gly Glu Pro Asn Asp Ile Ala 
    210                 215                 220                 
Trp Ile Cys Val Tyr Leu Ala Ser Xaa Glu Xaa Lys Phe Ala Thr Gly 
225                 230                 235                 240 
Ala Glu Phe Val Val Asp Gly Xaa Tyr Thr Ala Gln                 
                245                 250                         
