                               SEQUENCE LISTING                               

<110> PRESIDENT AND FELLOWS OF HARVARD COLLEGE, et al.

<120> THE USE OF MICE PREDISPOSED TO DEVELOP ULCERATIVE COLITIS 
      AND COLON CANCER TO DEVELOP METABOLIC PROFILES ASSOCIATED WITH SAME 

<130> HUI-069BPC

<140> Not Yet Available
<141> Concurrently Herewith

<150> 60/995,036
<151> 2007-09-24

<150> 60/066,319
<151> 2008-02-20

<150> 60/128,376
<151> 2008-05-21

<160> 4

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1608
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (1)..(1605)

<400> 1
atg ggc atc gtg gag ccg ggt tgc gga gac atg ctg acg ggc acc gag   48    
Met Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr Glu
  1               5                  10                  15    

ccg atg ccg ggg agc gac gag ggc cgg gcg cct ggc gcc gac ccg cag   96    
Pro Met Pro Gly Ser Asp Glu Gly Arg Ala Pro Gly Ala Asp Pro Gln
             20                  25                  30        

cac cgc tac ttc tac ccg gag ccg ggc gcg cag gac gcg gac gag cgt   144   
His Arg Tyr Phe Tyr Pro Glu Pro Gly Ala Gln Asp Ala Asp Glu Arg
         35                  40                  45            

cgc ggg ggc ggc agc ctg ggg tct ccc tac ccg ggg ggc gcc ttg gtg   192   
Arg Gly Gly Gly Ser Leu Gly Ser Pro Tyr Pro Gly Gly Ala Leu Val
     50                  55                  60                

ccc gcc ccg ccg agc cgc ttc ctt gga gcc tac gcc tac ccg ccg cga   240   
Pro Ala Pro Pro Ser Arg Phe Leu Gly Ala Tyr Ala Tyr Pro Pro Arg
 65                  70                  75                  80

ccc cag gcg gcc ggc ttc ccc ggc gcg ggc gag tcc ttc ccg ccg ccc   288   
Pro Gln Ala Ala Gly Phe Pro Gly Ala Gly Glu Ser Phe Pro Pro Pro
                 85                  90                  95    

gcg gac gcc gag ggc tac cag ccg ggc gag ggc tac gcc gcc ccg gac   336   
Ala Asp Ala Glu Gly Tyr Gln Pro Gly Glu Gly Tyr Ala Ala Pro Asp
            100                 105                 110        

ccg cgc gcc ggg ctc tac ccg ggg ccg cgt gag gac tac gcg cta ccc   384   
Pro Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro
        115                 120                 125            

gcg gga ctg gag gtg tcg ggg aaa ctg agg gtc gcg ctc aac aac cac   432   
Ala Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Asn Asn His
    130                 135                 140                

ctg ttg tgg tcc aag ttt aat cag cac cag aca gag atg atc atc acc   480   
Leu Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr
145                 150                 155                 160

aag cag gga cgg cgg atg ttc cca ttc ctg tca ttt act gtg gcc ggg   528   
Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly
                165                 170                 175    

ctg gag ccc acc agc cac tac agg atg ttt gtg gac gtg gtc ttg gtg   576   
Leu Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val
            180                 185                 190        

gac cag cac cac tgg cgg tac cag agc ggc aag tgg gtg cag tgt gga   624   
Asp Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly
        195                 200                 205            

aag gcc gag ggc agc atg cca gga aac cgc ctg tac gtc cac ccg gac   672   
Lys Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp
    210                 215                 220                

tcc ccc aac aca gga gcg cac tgg atg cgc cag gaa gtt tca ttt ggg   720   
Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly
225                 230                 235                 240

aaa cta aag ctc aca aac aac aag ggg gcg tcc aac aat gtg acc cag   768   
Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln
                245                 250                 255    

atg att gtg ctc cag tcc ctc cat aag tac cag ccc cgg ctg cat atc   816   
Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile
            260                 265                 270        

gtt gag gtg aac gac gga gag cca gag gca gcc tgc aac gct tcc aac   864   
Val Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Asn Ala Ser Asn
        275                 280                 285            

acg cat atc ttt act ttc caa gaa acc cag ttc att gcc gtg act gcc   912   
Thr His Ile Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala
    290                 295                 300                

tac cag aat gcc gag att act cag ctg aaa att gat aat aac ccc ttt   960   
Tyr Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe
305                 310                 315                 320

gcc aaa gga ttc cgg gag aac ttt gag tcc atg tac aca tct gtt gac   1008  
Ala Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Thr Ser Val Asp
                325                 330                 335    

acc agc atc ccc tcc ccg cct gga ccc aac tgt caa ttc ctt ggg gga   1056  
Thr Ser Ile Pro Ser Pro Pro Gly Pro Asn Cys Gln Phe Leu Gly Gly
            340                 345                 350        

gat cac tac tct cct ctc cta ccc aac cag tat cct gtt ccc agc cgc   1104  
Asp His Tyr Ser Pro Leu Leu Pro Asn Gln Tyr Pro Val Pro Ser Arg
        355                 360                 365            

ttc tac ccc gac ctt cct ggc cag gcg aag gat gtg gtt ccc cag gct   1152  
Phe Tyr Pro Asp Leu Pro Gly Gln Ala Lys Asp Val Val Pro Gln Ala
    370                 375                 380                

tac tgg ctg ggg gcc ccc cgg gac cac agc tat gag gct gag ttt cga   1200  
Tyr Trp Leu Gly Ala Pro Arg Asp His Ser Tyr Glu Ala Glu Phe Arg
385                 390                 395                 400

gca gtc agc atg aag cct gca ttc ttg ccc tct gcc cct ggg ccc acc   1248  
Ala Val Ser Met Lys Pro Ala Phe Leu Pro Ser Ala Pro Gly Pro Thr
                405                 410                 415    

atg tcc tac tac cga ggc cag gag gtc ctg gca cct gga gct ggc tgg   1296  
Met Ser Tyr Tyr Arg Gly Gln Glu Val Leu Ala Pro Gly Ala Gly Trp
            420                 425                 430        

cct gtg gca ccc cag tac cct ccc aag atg ggc ccg gcc agc tgg ttc   1344  
Pro Val Ala Pro Gln Tyr Pro Pro Lys Met Gly Pro Ala Ser Trp Phe
        435                 440                 445            

cgc cct atg cgg act ctg ccc atg gaa ccc ggc cct gga ggc tca gag   1392  
Arg Pro Met Arg Thr Leu Pro Met Glu Pro Gly Pro Gly Gly Ser Glu
    450                 455                 460                

gga cgg gga cca gag gac cag ggt ccc ccc ttg gtg tgg act gag att   1440  
Gly Arg Gly Pro Glu Asp Gln Gly Pro Pro Leu Val Trp Thr Glu Ile
465                 470                 475                 480

gcc ccc atc cgg ccg gaa tcc agt gat tca gga ctg ggc gaa gga gac   1488  
Ala Pro Ile Arg Pro Glu Ser Ser Asp Ser Gly Leu Gly Glu Gly Asp
                485                 490                 495    

tct aag agg agg cgc gtg tcc ccc tat cct tcc agt ggt gac agc tcc   1536  
Ser Lys Arg Arg Arg Val Ser Pro Tyr Pro Ser Ser Gly Asp Ser Ser
            500                 505                 510        

tcc cct gct ggg gcc cct tct cct ttt gat aag gaa gct gaa gga cag   1584  
Ser Pro Ala Gly Ala Pro Ser Pro Phe Asp Lys Glu Ala Glu Gly Gln
        515                 520                 525            

ttt tat aac tat ttt ccc aac tga                                   1608  
Phe Tyr Asn Tyr Phe Pro Asn    
    530                 535    


<210> 2
<211> 535
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr Glu  
  1               5                  10                  15      

Pro Met Pro Gly Ser Asp Glu Gly Arg Ala Pro Gly Ala Asp Pro Gln  
             20                  25                  30          

His Arg Tyr Phe Tyr Pro Glu Pro Gly Ala Gln Asp Ala Asp Glu Arg  
         35                  40                  45              

Arg Gly Gly Gly Ser Leu Gly Ser Pro Tyr Pro Gly Gly Ala Leu Val  
     50                  55                  60                  

Pro Ala Pro Pro Ser Arg Phe Leu Gly Ala Tyr Ala Tyr Pro Pro Arg  
 65                  70                  75                  80  

Pro Gln Ala Ala Gly Phe Pro Gly Ala Gly Glu Ser Phe Pro Pro Pro  
                 85                  90                  95      

Ala Asp Ala Glu Gly Tyr Gln Pro Gly Glu Gly Tyr Ala Ala Pro Asp  
            100                 105                 110          

Pro Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro  
        115                 120                 125              

Ala Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Asn Asn His  
    130                 135                 140                  

Leu Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr  
145                 150                 155                 160  

Lys Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly  
                165                 170                 175      

Leu Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val  
            180                 185                 190          

Asp Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly  
        195                 200                 205              

Lys Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp  
    210                 215                 220                  

Ser Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly  
225                 230                 235                 240  

Lys Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln  
                245                 250                 255      

Met Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile  
            260                 265                 270          

Val Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Asn Ala Ser Asn  
        275                 280                 285              

Thr His Ile Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala  
    290                 295                 300                  

Tyr Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe  
305                 310                 315                 320  

Ala Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Thr Ser Val Asp  
                325                 330                 335      

Thr Ser Ile Pro Ser Pro Pro Gly Pro Asn Cys Gln Phe Leu Gly Gly  
            340                 345                 350          

Asp His Tyr Ser Pro Leu Leu Pro Asn Gln Tyr Pro Val Pro Ser Arg  
        355                 360                 365              

Phe Tyr Pro Asp Leu Pro Gly Gln Ala Lys Asp Val Val Pro Gln Ala  
    370                 375                 380                  

Tyr Trp Leu Gly Ala Pro Arg Asp His Ser Tyr Glu Ala Glu Phe Arg  
385                 390                 395                 400  

Ala Val Ser Met Lys Pro Ala Phe Leu Pro Ser Ala Pro Gly Pro Thr  
                405                 410                 415      

Met Ser Tyr Tyr Arg Gly Gln Glu Val Leu Ala Pro Gly Ala Gly Trp  
            420                 425                 430          

Pro Val Ala Pro Gln Tyr Pro Pro Lys Met Gly Pro Ala Ser Trp Phe  
        435                 440                 445              

Arg Pro Met Arg Thr Leu Pro Met Glu Pro Gly Pro Gly Gly Ser Glu  
    450                 455                 460                  

Gly Arg Gly Pro Glu Asp Gln Gly Pro Pro Leu Val Trp Thr Glu Ile  
465                 470                 475                 480  

Ala Pro Ile Arg Pro Glu Ser Ser Asp Ser Gly Leu Gly Glu Gly Asp  
                485                 490                 495      

Ser Lys Arg Arg Arg Val Ser Pro Tyr Pro Ser Ser Gly Asp Ser Ser  
            500                 505                 510          

Ser Pro Ala Gly Ala Pro Ser Pro Phe Asp Lys Glu Ala Glu Gly Gln  
        515                 520                 525              

Phe Tyr Asn Tyr Phe Pro Asn                                      
    530                 535                                      


<210> 3
<211> 1593
<212> DNA
<213> Mus musculus

<220> 
<221> CDS
<222> (1)..(1590)

<400> 3
atg ggc atc gtg gag ccg ggc tgc gga gac atg ctg acc ggc acc gag   48    
Met Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr Glu
  1               5                  10                  15    

ccg atg ccg agt gac gag ggc cgg ggg ccc gga gcg gac caa cag cat   96    
Pro Met Pro Ser Asp Glu Gly Arg Gly Pro Gly Ala Asp Gln Gln His
             20                  25                  30        

cgt ttc ttc tat ccc gag ccg ggc gca cag gac ccg acc gat cgc cgc   144   
Arg Phe Phe Tyr Pro Glu Pro Gly Ala Gln Asp Pro Thr Asp Arg Arg
         35                  40                  45            

gca ggt agc agc ctg ggg acg ccc tac tct ggg ggc gcc ctg gtg cct   192   
Ala Gly Ser Ser Leu Gly Thr Pro Tyr Ser Gly Gly Ala Leu Val Pro
     50                  55                  60                

gcc gcg ccg ggt cgc ttc ctt gga tcc ttc gcc tac ccg ccc cgg gct   240   
Ala Ala Pro Gly Arg Phe Leu Gly Ser Phe Ala Tyr Pro Pro Arg Ala
 65                  70                  75                  80

cag gtg gct ggc ttt ccc ggg cct ggc gag ttc ttc ccg ccg ccc gcg   288   
Gln Val Ala Gly Phe Pro Gly Pro Gly Glu Phe Phe Pro Pro Pro Ala
                 85                  90                  95    

ggt gcg gag ggc tac ccg ccc gtg gat ggc tac cct gcc cct gac ccg   336   
Gly Ala Glu Gly Tyr Pro Pro Val Asp Gly Tyr Pro Ala Pro Asp Pro
            100                 105                 110        

cgc gcg ggg ctc tac cca ggg ccg cgc gag gac tac gca ttg ccc gcg   384   
Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro Ala
        115                 120                 125            

ggg ttg gag gtg tct ggg aag ctg aga gtc gcg ctc agc aac cac ctg   432   
Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Ser Asn His Leu
    130                 135                 140                

ttg tgg tcc aag ttc aac cag cac cag aca gag atg atc atc act aag   480   
Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr Lys
145                 150                 155                 160

caa gga cgg cga atg ttc cca ttc ctg tcc ttc acc gtg gcc ggg ctg   528   
Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly Leu
                165                 170                 175    

gag ccc aca agc cat tac agg atg ttt gtg gat gtg gtc ttg gtg gac   576   
Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val Asp
            180                 185                 190        

cag cac cac tgg cgg tac cag agc ggc aag tgg gtg cag tgt gga aag   624   
Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly Lys
        195                 200                 205            

gca gaa ggc agc atg cca ggg aac cgc tta tat gtc cac cca gac tcc   672   
Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp Ser
    210                 215                 220                

ccc aac acc gga gcc cac tgg atg cgc cag gaa gtt tca ttt ggg aag   720   
Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly Lys
225                 230                 235                 240

cta aag ctc acc aac aac aag ggg gct tcc aac aat gtg acc cag atg   768   
Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln Met
                245                 250                 255    

atc gtc ctg cag tct ctc cac aag tac cag ccc cgg ctg cac atc gtg   816   
Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile Val
            260                 265                 270        

gag gtg aat gat gga gag cca gag gct gcc tgc agt gct tct aac aca   864   
Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Ser Ala Ser Asn Thr
        275                 280                 285            

cac gtc ttt act ttc caa gag acc cag ttc att gca gtg act gcc tac   912   
His Val Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr
    290                 295                 300                

cag aac gca gag atc act cag ctg aaa atc gac aac aac ccc ttt gcc   960   
Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe Ala
305                 310                 315                 320

aaa gga ttc cgg gag aac ttt gag tcc atg tac gca tct gtt gat acg   1008  
Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Ala Ser Val Asp Thr
                325                 330                 335    

agt gtc ccc tcg cca cct gga ccc aac tgt caa ctg ctt ggg gga gac   1056  
Ser Val Pro Ser Pro Pro Gly Pro Asn Cys Gln Leu Leu Gly Gly Asp
            340                 345                 350        

ccc ttc tca cct ctt cta tcc aac cag tat cct gtt ccc agc cgt ttc   1104  
Pro Phe Ser Pro Leu Leu Ser Asn Gln Tyr Pro Val Pro Ser Arg Phe
        355                 360                 365            

tac ccc gac ctt cca ggc cag ccc aag gat atg atc tca cag cct tac   1152  
Tyr Pro Asp Leu Pro Gly Gln Pro Lys Asp Met Ile Ser Gln Pro Tyr
    370                 375                 380                

tgg ctg ggg aca cct cgg gaa cac agt tat gaa gcg gag ttc cga gct   1200  
Trp Leu Gly Thr Pro Arg Glu His Ser Tyr Glu Ala Glu Phe Arg Ala
385                 390                 395                 400

gtg agc atg aag ccc aca ctc cta ccc tct gcc ccg ggg ccc act gtg   1248  
Val Ser Met Lys Pro Thr Leu Leu Pro Ser Ala Pro Gly Pro Thr Val
                405                 410                 415    

ccc tac tac cgg ggc caa gac gtc ctg gcg cct gga gct ggt tgg ccc   1296  
Pro Tyr Tyr Arg Gly Gln Asp Val Leu Ala Pro Gly Ala Gly Trp Pro
            420                 425                 430        

gtg gcc cct caa tac ccg ccc aag atg agc cca gct ggc tgg ttc cgg   1344  
Val Ala Pro Gln Tyr Pro Pro Lys Met Ser Pro Ala Gly Trp Phe Arg
        435                 440                 445            

ccc atg cga act ctg ccc atg gac ccg ggc ctg gga tcc tca gag gaa   1392  
Pro Met Arg Thr Leu Pro Met Asp Pro Gly Leu Gly Ser Ser Glu Glu
    450                 455                 460                

cag ggc tcc tcc ccc tcg ctg tgg cct gag gtc acc tcc ctc cag ccg   1440  
Gln Gly Ser Ser Pro Ser Leu Trp Pro Glu Val Thr Ser Leu Gln Pro
465                 470                 475                 480

gag ccc agc gac tca gga cta ggc gaa gga gac act aag agg agg agg   1488  
Glu Pro Ser Asp Ser Gly Leu Gly Glu Gly Asp Thr Lys Arg Arg Arg
                485                 490                 495    

ata tcc ccc tat cct tcc agt ggc gac agc tcc tct ccc gct ggg gcc   1536  
Ile Ser Pro Tyr Pro Ser Ser Gly Asp Ser Ser Ser Pro Ala Gly Ala
            500                 505                 510        

cct tct cct ttt gat aag gaa acc gaa ggc cag ttt tat aat tat ttt   1584  
Pro Ser Pro Phe Asp Lys Glu Thr Glu Gly Gln Phe Tyr Asn Tyr Phe
        515                 520                 525            

ccc aac tga                                                       1593  
Pro Asn    
    530    


<210> 4
<211> 530
<212> PRT
<213> Mus musculus

<400> 4
Met Gly Ile Val Glu Pro Gly Cys Gly Asp Met Leu Thr Gly Thr Glu  
  1               5                  10                  15      

Pro Met Pro Ser Asp Glu Gly Arg Gly Pro Gly Ala Asp Gln Gln His  
             20                  25                  30          

Arg Phe Phe Tyr Pro Glu Pro Gly Ala Gln Asp Pro Thr Asp Arg Arg  
         35                  40                  45              

Ala Gly Ser Ser Leu Gly Thr Pro Tyr Ser Gly Gly Ala Leu Val Pro  
     50                  55                  60                  

Ala Ala Pro Gly Arg Phe Leu Gly Ser Phe Ala Tyr Pro Pro Arg Ala  
 65                  70                  75                  80  

Gln Val Ala Gly Phe Pro Gly Pro Gly Glu Phe Phe Pro Pro Pro Ala  
                 85                  90                  95      

Gly Ala Glu Gly Tyr Pro Pro Val Asp Gly Tyr Pro Ala Pro Asp Pro  
            100                 105                 110          

Arg Ala Gly Leu Tyr Pro Gly Pro Arg Glu Asp Tyr Ala Leu Pro Ala  
        115                 120                 125              

Gly Leu Glu Val Ser Gly Lys Leu Arg Val Ala Leu Ser Asn His Leu  
    130                 135                 140                  

Leu Trp Ser Lys Phe Asn Gln His Gln Thr Glu Met Ile Ile Thr Lys  
145                 150                 155                 160  

Gln Gly Arg Arg Met Phe Pro Phe Leu Ser Phe Thr Val Ala Gly Leu  
                165                 170                 175      

Glu Pro Thr Ser His Tyr Arg Met Phe Val Asp Val Val Leu Val Asp  
            180                 185                 190          

Gln His His Trp Arg Tyr Gln Ser Gly Lys Trp Val Gln Cys Gly Lys  
        195                 200                 205              

Ala Glu Gly Ser Met Pro Gly Asn Arg Leu Tyr Val His Pro Asp Ser  
    210                 215                 220                  

Pro Asn Thr Gly Ala His Trp Met Arg Gln Glu Val Ser Phe Gly Lys  
225                 230                 235                 240  

Leu Lys Leu Thr Asn Asn Lys Gly Ala Ser Asn Asn Val Thr Gln Met  
                245                 250                 255      

Ile Val Leu Gln Ser Leu His Lys Tyr Gln Pro Arg Leu His Ile Val  
            260                 265                 270          

Glu Val Asn Asp Gly Glu Pro Glu Ala Ala Cys Ser Ala Ser Asn Thr  
        275                 280                 285              

His Val Phe Thr Phe Gln Glu Thr Gln Phe Ile Ala Val Thr Ala Tyr  
    290                 295                 300                  

Gln Asn Ala Glu Ile Thr Gln Leu Lys Ile Asp Asn Asn Pro Phe Ala  
305                 310                 315                 320  

Lys Gly Phe Arg Glu Asn Phe Glu Ser Met Tyr Ala Ser Val Asp Thr  
                325                 330                 335      

Ser Val Pro Ser Pro Pro Gly Pro Asn Cys Gln Leu Leu Gly Gly Asp  
            340                 345                 350          

Pro Phe Ser Pro Leu Leu Ser Asn Gln Tyr Pro Val Pro Ser Arg Phe  
        355                 360                 365              

Tyr Pro Asp Leu Pro Gly Gln Pro Lys Asp Met Ile Ser Gln Pro Tyr  
    370                 375                 380                  

Trp Leu Gly Thr Pro Arg Glu His Ser Tyr Glu Ala Glu Phe Arg Ala  
385                 390                 395                 400  

Val Ser Met Lys Pro Thr Leu Leu Pro Ser Ala Pro Gly Pro Thr Val  
                405                 410                 415      

Pro Tyr Tyr Arg Gly Gln Asp Val Leu Ala Pro Gly Ala Gly Trp Pro  
            420                 425                 430          

Val Ala Pro Gln Tyr Pro Pro Lys Met Ser Pro Ala Gly Trp Phe Arg  
        435                 440                 445              

Pro Met Arg Thr Leu Pro Met Asp Pro Gly Leu Gly Ser Ser Glu Glu  
    450                 455                 460                  

Gln Gly Ser Ser Pro Ser Leu Trp Pro Glu Val Thr Ser Leu Gln Pro  
465                 470                 475                 480  

Glu Pro Ser Asp Ser Gly Leu Gly Glu Gly Asp Thr Lys Arg Arg Arg  
                485                 490                 495      

Ile Ser Pro Tyr Pro Ser Ser Gly Asp Ser Ser Ser Pro Ala Gly Ala  
            500                 505                 510          

Pro Ser Pro Phe Asp Lys Glu Thr Glu Gly Gln Phe Tyr Asn Tyr Phe  
        515                 520                 525              

Pro Asn                                                          
    530                                                          
HUI-069BPC


10


