                         SEQUENCE LISTING

<110>  University of Florida Research Foundation, Inc.
       Lyons, Thomas John
       Kupchak, Brian R.
       Smith, Jessica L.
       Garitaonandia, Ibon
 
<120>  High Throughput Assays for Inhibitors and Activators of PAQR 
       Receptors

<130>  UF.614CXC1

<150>  US 61/042,537
<151>  2008-04-04

<150>  US 60/974,657
<151>  2007-09-24

<160>  172   

<170>  PatentIn version 3.3

<210>  1
<211>  1128
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  adiponectin receptor 1

<220>
<221>  CDS
<222>  (1)..(1128)

<400>  1
atg tct tcc cac aaa gga tct gtg gtg gca cag ggg aat ggg gct cct       48
Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro         
1               5                   10                  15              

gcc agt aac agg gaa gct gac acg gtg gaa ctg gct gaa ctg gga ccc       96
Ala Ser Asn Arg Glu Ala Asp Thr Val Glu Leu Ala Glu Leu Gly Pro         
            20                  25                  30                  

ctg cta gaa gag aag ggc aaa cgg gta atc gcc aac cca ccc aaa gct      144
Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala         
        35                  40                  45                      

gaa gaa gag caa aca tgc cca gtg ccc cag gaa gaa gag gag gag gtg      192
Glu Glu Glu Gln Thr Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val         
    50                  55                  60                          

cgg gta ctg aca ctt ccc ctg caa gcc cac cac gcc atg gag aag atg      240
Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met         
65                  70                  75                  80          

gaa gag ttt gtg tac aag gtc tgg gag gga cgt tgg agg gtc atc cca      288
Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro         
                85                  90                  95              

tat gat gtg ctc cct gac tgg cta aag gac aac gac tat ctg cta cat      336
Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His         
            100                 105                 110                 

ggt cat aga cct ccc atg ccc tcc ttt cgg gct tgc ttc aag agc atc      384
Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile         
        115                 120                 125                     

ttc cgc att cat aca gaa act ggc aac atc tgg acc cat ctg ctt ggt      432
Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly         
    130                 135                 140                         

ttc gtg ctg ttt ctc ttt ttg gga atc ttg acc atg ctc aga cca aat      480
Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn         
145                 150                 155                 160         

atg tac ttc atg gcc cct cta cag gag aag gtg gtt ttt ggg atg ttc      528
Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe         
                165                 170                 175             

ttt ttg ggt gca gtg ctc tgc ctc agc ttc tcc tgg ctc ttt cac acc      576
Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr         
            180                 185                 190                 

gtc tat tgt cat tca gag aaa gtc tct cgg act ttt tcc aaa ctg gac      624
Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp         
        195                 200                 205                     

tat tca ggg att gct ctt cta att atg ggg agc ttt gtc ccc tgg ctc      672
Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu         
    210                 215                 220                         

tat tat tcc ttc tac tgc tcc cca cag cca cgg ctc atc tac ctc tcc      720
Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser         
225                 230                 235                 240         

atc gtc tgt gtc ctg ggc att tct gcc atc att gtg gcg cag tgg gac      768
Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp         
                245                 250                 255             

cgg ttt gcc act cct aag cac cgg cag aca aga gca ggc gtg ttc ctg      816
Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu         
            260                 265                 270                 

gga ctt ggc ttg agt ggc gtc gtg ccc acc atg cac ttt act atc gct      864
Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala         
        275                 280                 285                     

gag ggc ttt gtc aag gcc acc aca gtg ggc cag atg ggc tgg ttc ttc      912
Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe         
    290                 295                 300                         

ctc atg gct gtg atg tac atc act gga gct ggc ctt tat gct gct cga      960
Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg         
305                 310                 315                 320         

att cct gag cgc ttc ttt cct gga aaa ttt gac ata tgg ttc cag tct     1008
Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser         
                325                 330                 335             

cat cag att ttc cat gtc ctg gtg gtg gca gca gcc ttt gtc cac ttc     1056
His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe         
            340                 345                 350                 

tat gga gtc tcc aac ctt cag gaa ttc cgt tac ggc cta gaa ggc ggc     1104
Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly         
        355                 360                 365                     

tgt act gat gac acc ctt ctc tga                                     1128
Cys Thr Asp Asp Thr Leu Leu                                             
    370                 375                                             


<210>  2
<211>  375
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Ser His Lys Gly Ser Val Val Ala Gln Gly Asn Gly Ala Pro 
1               5                   10                  15      


Ala Ser Asn Arg Glu Ala Asp Thr Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          


Leu Leu Glu Glu Lys Gly Lys Arg Val Ile Ala Asn Pro Pro Lys Ala 
        35                  40                  45              


Glu Glu Glu Gln Thr Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  


Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  


Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      


Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         


Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             


Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 


Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 


Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     


Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         


Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             


Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 


Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         


Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             


Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 


Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 


Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     


His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         


Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Thr Asp Asp Thr Leu Leu 
    370                 375 


<210>  3
<211>  1161
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  adiponectin receptor 2 (ADIPOR2), mRNA

<220>
<221>  CDS
<222>  (1)..(1161)

<400>  3
atg aac gag cca aca gaa aac cga ttg ggg tgc agc agg act cca gag       48
Met Asn Glu Pro Thr Glu Asn Arg Leu Gly Cys Ser Arg Thr Pro Glu         
1               5                   10                  15              

cca gat ata agg ctc aga aaa ggg cac caa ctg gat ggt aca cga aga       96
Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Thr Arg Arg         
            20                  25                  30                  

ggt gat aat gac agc cac caa gga gat ttg gag ccc att tta gag gca      144
Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala         
        35                  40                  45                      

tct gtt cta tct tcc cat cat aaa aaa agc tct gag gaa cat gaa tac      192
Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr         
    50                  55                  60                          

agt gat gaa gct cct cag gaa gat gag ggc ttt atg ggc atg tcc cct      240
Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro         
65                  70                  75                  80          

ctc tta caa gcc cat cat gct atg gaa aaa atg gaa gaa ttt gtt tgt      288
Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys         
                85                  90                  95              

aag gta tgg gaa ggt cgg tgg cga gtg atc cct cat gat gta cta cca      336
Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro         
            100                 105                 110                 

gac tgg ctc aag gat aat gac ttc ctc ttg cat gga cac cgg cct cct      384
Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro         
        115                 120                 125                     

atg cct tct ttc cgg gcc tgt ttt aag agc att ttc aga ata cac aca      432
Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr         
    130                 135                 140                         

gaa aca ggc aac att tgg aca cat ctc tta ggt tgt gta ttc ttc ctg      480
Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe Leu         
145                 150                 155                 160         

tgc ctg ggg atc ttt tat atg ttt cgc cca aat atc tcc ttt gtg gcc      528
Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala         
                165                 170                 175             

cct ctg caa gag aag gtg gtc ttt gga tta ttt ttc tta gga gcc att      576
Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile         
            180                 185                 190                 

ctc tgc ctt tct ttt tca tgg ctc ttc cac aca gtc tac tgc cac tca      624
Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser         
        195                 200                 205                     

gag ggg gtc tct cgg ctc ttc tct aaa ctg gat tac tct ggt att gct      672
Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala         
    210                 215                 220                         

ctt ctg att atg gga agt ttt gtt cct tgg ctt tat tat tct ttc tac      720
Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr         
225                 230                 235                 240         

tgt aat cca caa cct tgc ttc atc tac ttg att gtc atc tgt gtg ctg      768
Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu         
                245                 250                 255             

ggc att gca gcc att ata gtc tcc cag tgg gac atg ttt gcc acc cct      816
Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro         
            260                 265                 270                 

cag tat cgg gga gta aga gca gga gtg ttt ttg ggc cta ggc ctg agt      864
Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser         
        275                 280                 285                     

gga atc att cct acc ttg cac tat gtc atc tcg gag ggg ttc ctt aag      912
Gly Ile Ile Pro Thr Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys         
    290                 295                 300                         

gcc gcc acc ata ggg cag ata ggc tgg ttg atg ctg atg gcc agc ctc      960
Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu         
305                 310                 315                 320         

tac atc aca gga gct gcc ctg tat gct gcc cgg atc ccc gaa cgc ttt     1008
Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe         
                325                 330                 335             

ttc cct ggc aaa tgt gac atc tgg ttt cac tct cat cag ctg ttt cat     1056
Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His         
            340                 345                 350                 

atc ttt gtg gtt gct gga gct ttt gtt cac ttc cat ggt gtc tca aac     1104
Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn         
        355                 360                 365                     

ctc cag gag ttt cgt ttc atg atc ggc ggg ggc tgc agt gaa gag gat     1152
Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp         
    370                 375                 380                         

gca ctg tga                                                         1161
Ala Leu                                                                 
385                                                                     


<210>  4
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asn Glu Pro Thr Glu Asn Arg Leu Gly Cys Ser Arg Thr Pro Glu 
1               5                   10                  15      


Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Thr Arg Arg 
            20                  25                  30          


Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala 
        35                  40                  45              


Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr 
    50                  55                  60                  


Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro 
65                  70                  75                  80  


Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys 
                85                  90                  95      


Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro 
            100                 105                 110         


Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro 
        115                 120                 125             


Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr 
    130                 135                 140                 


Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe Leu 
145                 150                 155                 160 


Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala 
                165                 170                 175     


Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile 
            180                 185                 190         


Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser 
        195                 200                 205             


Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala 
    210                 215                 220                 


Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr 
225                 230                 235                 240 


Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu 
                245                 250                 255     


Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro 
            260                 265                 270         


Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser 
        275                 280                 285             


Gly Ile Ile Pro Thr Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys 
    290                 295                 300                 


Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu 
305                 310                 315                 320 


Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe 
                325                 330                 335     


Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His 
            340                 345                 350         


Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn 
        355                 360                 365             


Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp 
    370                 375                 380                 


Ala Leu 
385     


<210>  5
<211>  810
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  progestin and adipoQ receptor family member III, mRNA (cDNA clone
       MGC:48508 IMAGE:5297045)

<220>
<221>  CDS
<222>  (1)..(810)

<400>  5
atg cat cag aag ctg ctg aag agc gcg cat tac atc gag ctg ggc agc       48
Met His Gln Lys Leu Leu Lys Ser Ala His Tyr Ile Glu Leu Gly Ser         
1               5                   10                  15              

tac cag tac tgg ccg gtc ctg gtg ccc cgt ggc atc cgc ctg tac acc       96
Tyr Gln Tyr Trp Pro Val Leu Val Pro Arg Gly Ile Arg Leu Tyr Thr         
            20                  25                  30                  

tac gag cag atc ccc ggg tcc ctc aag gac aac ccg tac atc acc gac      144
Tyr Glu Gln Ile Pro Gly Ser Leu Lys Asp Asn Pro Tyr Ile Thr Asp         
        35                  40                  45                      

ggc tac cgg gcc tac ctg ccg tcc agg ctg tgt atc aaa agt ttg ttt      192
Gly Tyr Arg Ala Tyr Leu Pro Ser Arg Leu Cys Ile Lys Ser Leu Phe         
    50                  55                  60                          

att tta tct aat gag aca gta aac atc tgg agt cat ttg ctg ggt ttc      240
Ile Leu Ser Asn Glu Thr Val Asn Ile Trp Ser His Leu Leu Gly Phe         
65                  70                  75                  80          

ttt ctc ttc ttc acc ctg gga ata tat gac atg aca tct gtg tta cct      288
Phe Leu Phe Phe Thr Leu Gly Ile Tyr Asp Met Thr Ser Val Leu Pro         
                85                  90                  95              

tca gca agt gcg tcc aga gaa gat ttt gta att tgt tct att tgt ctt      336
Ser Ala Ser Ala Ser Arg Glu Asp Phe Val Ile Cys Ser Ile Cys Leu         
            100                 105                 110                 

ttc tgc ttc cag gtc tgt atg ctt tgc tct gtg ggc tat cat ctt ttt      384
Phe Cys Phe Gln Val Cys Met Leu Cys Ser Val Gly Tyr His Leu Phe         
        115                 120                 125                     

tcc tgc cat cgg tca gaa aaa aca tgt cga aga tgg atg gca tta gat      432
Ser Cys His Arg Ser Glu Lys Thr Cys Arg Arg Trp Met Ala Leu Asp         
    130                 135                 140                         

tat gca gga att tct att gga ata ctg ggc tgc tat gtc tca gga gta      480
Tyr Ala Gly Ile Ser Ile Gly Ile Leu Gly Cys Tyr Val Ser Gly Val         
145                 150                 155                 160         

ttt tac gca ttt tat tgt aat aac tac tgg cgt cag gtg tac ttg atc      528
Phe Tyr Ala Phe Tyr Cys Asn Asn Tyr Trp Arg Gln Val Tyr Leu Ile         
                165                 170                 175             

aca gtg ctt gct atg atc ctg gca gtg ttc ttt gcg cag att cat ccc      576
Thr Val Leu Ala Met Ile Leu Ala Val Phe Phe Ala Gln Ile His Pro         
            180                 185                 190                 

aat tac ctc acg cag caa tgg caa agg ctc cgt tct atc atc ttt tgt      624
Asn Tyr Leu Thr Gln Gln Trp Gln Arg Leu Arg Ser Ile Ile Phe Cys         
        195                 200                 205                     

tct gtt tcg gga tat gga gtg att cct act ctt cac tgg gtt tgg ctc      672
Ser Val Ser Gly Tyr Gly Val Ile Pro Thr Leu His Trp Val Trp Leu         
    210                 215                 220                         

aat gga gga att ggt gct cct att gta cag gac ttt gca ccc cgt gta      720
Asn Gly Gly Ile Gly Ala Pro Ile Val Gln Asp Phe Ala Pro Arg Val         
225                 230                 235                 240         

att gtg atg tat atg att gct ctt ctt gct ttc cta ttc tac att tcc      768
Ile Val Met Tyr Met Ile Ala Leu Leu Ala Phe Leu Phe Tyr Ile Ser         
                245                 250                 255             

aaa gtc cca gag cgg tac ttt cca gaa tca ctt cca cgg tga              810
Lys Val Pro Glu Arg Tyr Phe Pro Glu Ser Leu Pro Arg                     
            260                 265                                     


<210>  6
<211>  269
<212>  PRT
<213>  Homo sapiens

<400>  6

Met His Gln Lys Leu Leu Lys Ser Ala His Tyr Ile Glu Leu Gly Ser 
1               5                   10                  15      


Tyr Gln Tyr Trp Pro Val Leu Val Pro Arg Gly Ile Arg Leu Tyr Thr 
            20                  25                  30          


Tyr Glu Gln Ile Pro Gly Ser Leu Lys Asp Asn Pro Tyr Ile Thr Asp 
        35                  40                  45              


Gly Tyr Arg Ala Tyr Leu Pro Ser Arg Leu Cys Ile Lys Ser Leu Phe 
    50                  55                  60                  


Ile Leu Ser Asn Glu Thr Val Asn Ile Trp Ser His Leu Leu Gly Phe 
65                  70                  75                  80  


Phe Leu Phe Phe Thr Leu Gly Ile Tyr Asp Met Thr Ser Val Leu Pro 
                85                  90                  95      


Ser Ala Ser Ala Ser Arg Glu Asp Phe Val Ile Cys Ser Ile Cys Leu 
            100                 105                 110         


Phe Cys Phe Gln Val Cys Met Leu Cys Ser Val Gly Tyr His Leu Phe 
        115                 120                 125             


Ser Cys His Arg Ser Glu Lys Thr Cys Arg Arg Trp Met Ala Leu Asp 
    130                 135                 140                 


Tyr Ala Gly Ile Ser Ile Gly Ile Leu Gly Cys Tyr Val Ser Gly Val 
145                 150                 155                 160 


Phe Tyr Ala Phe Tyr Cys Asn Asn Tyr Trp Arg Gln Val Tyr Leu Ile 
                165                 170                 175     


Thr Val Leu Ala Met Ile Leu Ala Val Phe Phe Ala Gln Ile His Pro 
            180                 185                 190         


Asn Tyr Leu Thr Gln Gln Trp Gln Arg Leu Arg Ser Ile Ile Phe Cys 
        195                 200                 205             


Ser Val Ser Gly Tyr Gly Val Ile Pro Thr Leu His Trp Val Trp Leu 
    210                 215                 220                 


Asn Gly Gly Ile Gly Ala Pro Ile Val Gln Asp Phe Ala Pro Arg Val 
225                 230                 235                 240 


Ile Val Met Tyr Met Ile Ala Leu Leu Ala Phe Leu Phe Tyr Ile Ser 
                245                 250                 255     


Lys Val Pro Glu Arg Tyr Phe Pro Glu Ser Leu Pro Arg 
            260                 265                 


<210>  7
<211>  2459
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  progestin and adipoQ receptor family member IV

<220>
<221>  CDS
<222>  (89)..(910)

<400>  7
ccacgcgtcc ggccttcccg cgctgcggcc ccactgagga ggaggctcgg ggacagcagg     60

agcacgggct gcccgcgcgg tgcggacc atg gcg ttc ctg gcc ggg ccg cgc       112
                               Met Ala Phe Leu Ala Gly Pro Arg          
                               1               5                        

ctg ctg gac tgg gcc agc tcg ccg ccg cac ctg cag ttc aat aag ttc      160
Leu Leu Asp Trp Ala Ser Ser Pro Pro His Leu Gln Phe Asn Lys Phe         
    10                  15                  20                          

gtg ctg acc ggg tac cgg ccc gcc agc agc ggc tcg ggc tgc ctg cgc      208
Val Leu Thr Gly Tyr Arg Pro Ala Ser Ser Gly Ser Gly Cys Leu Arg         
25                  30                  35                  40          

agc ctc ttc tac ctg cac aac gaa ctg ggc aac atc tac acg cac ggg      256
Ser Leu Phe Tyr Leu His Asn Glu Leu Gly Asn Ile Tyr Thr His Gly         
                45                  50                  55              

ctg gcc ctg ctg ggc ttc ctg gtg ctg gtg cca atg acc atg ccc tgg      304
Leu Ala Leu Leu Gly Phe Leu Val Leu Val Pro Met Thr Met Pro Trp         
            60                  65                  70                  

ggt cag ctg ggc aag gat ggc tgg ctg gga ggc aca cat tgc gtg gcc      352
Gly Gln Leu Gly Lys Asp Gly Trp Leu Gly Gly Thr His Cys Val Ala         
        75                  80                  85                      

tgc ctt gca ccc cct gca ggc tcc gtg ctc tat cac ctc ttt atg tgc      400
Cys Leu Ala Pro Pro Ala Gly Ser Val Leu Tyr His Leu Phe Met Cys         
    90                  95                  100                         

cac caa ggg ggc agc gct gtg tac gcc cgg ctc ctc gcc ctg gac atg      448
His Gln Gly Gly Ser Ala Val Tyr Ala Arg Leu Leu Ala Leu Asp Met         
105                 110                 115                 120         

tgt ggg gtc tgc ctt gtc aac acc ctt ggg gcc ctg ccc atc atc cac      496
Cys Gly Val Cys Leu Val Asn Thr Leu Gly Ala Leu Pro Ile Ile His         
                125                 130                 135             

tgc acc ctg gcc tgc agg ccc tgg ctg cgc ccg gct gcc ctg gtg ggc      544
Cys Thr Leu Ala Cys Arg Pro Trp Leu Arg Pro Ala Ala Leu Val Gly         
            140                 145                 150                 

tac act gtg ttg tcg ggt gtg gcc ggc tgg cgt gct ctc acc gcc ccc      592
Tyr Thr Val Leu Ser Gly Val Ala Gly Trp Arg Ala Leu Thr Ala Pro         
        155                 160                 165                     

tcc acc agt gct cgg ctc cgg gca ttt gga tgg cag gct gct gcc cgc      640
Ser Thr Ser Ala Arg Leu Arg Ala Phe Gly Trp Gln Ala Ala Ala Arg         
    170                 175                 180                         

cta ctg gta ttt ggg gcc cgg gga gtg ggt ctg ggt tca ggg gct cca      688
Leu Leu Val Phe Gly Ala Arg Gly Val Gly Leu Gly Ser Gly Ala Pro         
185                 190                 195                 200         

ggc tcc ctg ccc tgc tac ctg cgc atg gac gca ctg gcg ctg ctt ggg      736
Gly Ser Leu Pro Cys Tyr Leu Arg Met Asp Ala Leu Ala Leu Leu Gly         
                205                 210                 215             

gga ctg gta aat gta gcc cgt ctg ccc gag cgc tgg gga cct ggc cgc      784
Gly Leu Val Asn Val Ala Arg Leu Pro Glu Arg Trp Gly Pro Gly Arg         
            220                 225                 230                 

ttt gac tac tgg ggc aac tcc cac cag atc atg cac ctg ctg agc gtg      832
Phe Asp Tyr Trp Gly Asn Ser His Gln Ile Met His Leu Leu Ser Val         
        235                 240                 245                     

ggc tcc atc ctg cag ctg cac gcc ggc gtc gtg ccc gac ctg ctc tgg      880
Gly Ser Ile Leu Gln Leu His Ala Gly Val Val Pro Asp Leu Leu Trp         
    250                 255                 260                         

gct gcc cac cac gcc tgt ccc cgg gac tga gctgccatgc cagcctgccc        930
Ala Ala His His Ala Cys Pro Arg Asp                                     
265                 270                                                 

acagcagcct cctagagtta gcaacaccag gtgttcctcc caactcgtct gcaaggggct    990

ggctccttgg atgcttccag ctcatgagat gtctcagcag gagccctgtt cacccgttct   1050

tccctgtgga ctgacctctt ccacccacgc cgtggcgctc caacttcctt ccctgccttt   1110

tccctccaag ctcctatttt actgtgtcag ctggaaggaa acctttccct cttgggacct   1170

ctttaccctc tgtgacctgt ggggttagac cagagaggga ctctggggtc atgtcttgct   1230

ctgagagttc aagtcctgcc aggccgccag cccagagcct cctcacccta tcctgttcct   1290

cccaccaggc ctgtggccag tcttcctgat ctccatcttt ctgccctgca taccagccct   1350

cccagcagcc acaagcttgc ccgccctggc tccctctgcc cagagactat ggagtaaggc   1410

attcaggaca aaaggaccaa gggggcgtgg acccgtcttg taccagctgg ccacaggcac   1470

aagggctgca gctgcttctt ccaggaaact gacacaggga gctcagcggc ctcagatcct   1530

gggacccctg ggccgtgcct gccctccacc ttgagtgcca tactcccaac agctccaggt   1590

acccaccggg ggatgtgcct gctcaggaaa cctctttgct ccacacagca tggggcttca   1650

gctgctggcc caaggccagg agcgctgggt tctgcagcag ggctcagcct caggggcgtt   1710

aagaccctgg atgacatcaa taaagggaca ggaagggcca tgttgccaca tgagcaagct   1770

tgggtgctcc caaggttcaa atacttttta ttagacacgg ccaggcagag aagaccatgg   1830

gagttcccga ggggccccag ctttcaaggg cgacgggaga gacacaggat aaaaggttaa   1890

aagtgcagag gcagagtctg gggctcaggt tgggtctagg gtgtcctcaa acaggctgag   1950

gaggttccga ggctcaaagg aggggaagga gccccgagga ggctctgagt tgatgtcact   2010

taggtccagg gcatccctgg gaggagagag tagtgacact caggatccaa aagctagccc   2070

tgcccacccc agcccctgga cctgcttacc tgggtgtgca cctgctccgg ggggtggagg   2130

tgctccccac agtccgggcc aggacagcct caggggagag tgaaggcctg caggagggca   2190

ggcgagacaa ggagggtgtc cagggctagg gagtgccgga tgaaaccagc tctgtccctg   2250

tgcaggctcc aggctcccgc ctgacaaaca ggcagggagc cacagtcagg gacaataaaa   2310

acttggtgca ctctgaaagc agcacttgga cagccttcaa agtccttcca tctggctgca   2370

ctccaaggcc ccctctgtcc ttttcagaac acatggactt ggaggcagat ttgaaataaa   2430

cttttagtaa atgtaaaaaa aaaaaaaaa                                     2459


<210>  8
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Phe Leu Ala Gly Pro Arg Leu Leu Asp Trp Ala Ser Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Pro Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Leu Gly Asn Ile Tyr Thr His Gly Leu Ala Leu Leu Gly Phe Leu Val 
    50                  55                  60                  


Leu Val Pro Met Thr Met Pro Trp Gly Gln Leu Gly Lys Asp Gly Trp 
65                  70                  75                  80  


Leu Gly Gly Thr His Cys Val Ala Cys Leu Ala Pro Pro Ala Gly Ser 
                85                  90                  95      


Val Leu Tyr His Leu Phe Met Cys His Gln Gly Gly Ser Ala Val Tyr 
            100                 105                 110         


Ala Arg Leu Leu Ala Leu Asp Met Cys Gly Val Cys Leu Val Asn Thr 
        115                 120                 125             


Leu Gly Ala Leu Pro Ile Ile His Cys Thr Leu Ala Cys Arg Pro Trp 
    130                 135                 140                 


Leu Arg Pro Ala Ala Leu Val Gly Tyr Thr Val Leu Ser Gly Val Ala 
145                 150                 155                 160 


Gly Trp Arg Ala Leu Thr Ala Pro Ser Thr Ser Ala Arg Leu Arg Ala 
                165                 170                 175     


Phe Gly Trp Gln Ala Ala Ala Arg Leu Leu Val Phe Gly Ala Arg Gly 
            180                 185                 190         


Val Gly Leu Gly Ser Gly Ala Pro Gly Ser Leu Pro Cys Tyr Leu Arg 
        195                 200                 205             


Met Asp Ala Leu Ala Leu Leu Gly Gly Leu Val Asn Val Ala Arg Leu 
    210                 215                 220                 


Pro Glu Arg Trp Gly Pro Gly Arg Phe Asp Tyr Trp Gly Asn Ser His 
225                 230                 235                 240 


Gln Ile Met His Leu Leu Ser Val Gly Ser Ile Leu Gln Leu His Ala 
                245                 250                 255     


Gly Val Val Pro Asp Leu Leu Trp Ala Ala His His Ala Cys Pro Arg 
            260                 265                 270         


Asp 
    


<210>  9
<211>  993
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  progestin and adipoQ receptor family member V (PAQR5), transcript
       variant 2, mRNA

<220>
<221>  CDS
<222>  (1)..(993)

<400>  9
atg ctg agc ctg aag ctc ccc agg ctg ttt agc ata gac cag ata ccc       48
Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln Ile Pro         
1               5                   10                  15              

cag gtg ttc cat gag caa ggc atc ctg ttc ggc tac cgc cat cca cag       96
Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His Pro Gln         
            20                  25                  30                  

agt tct gcc act gcc tgc atc ctc agc ctt ttc caa atg acc aat gag      144
Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr Asn Glu         
        35                  40                  45                      

act ctc aac att tgg act cac ttg ctg ccc ttc tgg ttc ttt gca tgg      192
Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe Ala Trp         
    50                  55                  60                          

agg ttt gtg act gca ctg tat atg aca gac atc aag aat gac agc tac      240
Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp Ser Tyr         
65                  70                  75                  80          

tcc tgg ccc atg ctt gtg tac atg tgc acc agc tgc gtg tac cca ctt      288
Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr Pro Leu         
                85                  90                  95              

gtg tcc agc tgt gcg cac acc ttc agc tct atg tcc aag aat gcc cgg      336
Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg         
            100                 105                 110                 

cac att tgc tac ttc ctg gac tat ggt gcc gtc aac ctc ttc agc ctg      384
His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu         
        115                 120                 125                     

ggc tca gcc att gcc tac tct gca tac acg ttc ccg gat gcg ctc atg      432
Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala Leu Met         
    130                 135                 140                         

tgc acc act ttc cat gac tac tac gtg gcc ctg gct gta ctg aac acc      480
Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu Asn Thr         
145                 150                 155                 160         

atc ctc agc aca ggc ctc tcc tgc tac tcc agg ttt ctt gaa atc cag      528
Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Ile Gln         
                165                 170                 175             

aag ccc aga ctc tgt aag gtg att cgt gtc ctc gcc ttt gct tat ccg      576
Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala Tyr Pro         
            180                 185                 190                 

tac acc tgg gac tcc ctc ccc atc ttc tac agg cta ttc ctg ttc cca      624
Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu Phe Pro         
        195                 200                 205                     

ggg gag agt gca caa aat gaa gcc acc tcg tac cac cag aag cac atg      672
Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys His Met         
    210                 215                 220                         

atc atg acc ctc ctg gcc tct ttc ttg tac tct gca cat ctg cca gaa      720
Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu Pro Glu         
225                 230                 235                 240         

cgc cta gcc cct gga cgc ttt gac tac atc ggt cac agt cac cag ctg      768
Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu         
                245                 250                 255             

ttt cac gtg tgt gtg atc ctg gcc acg cac atg cag atg gaa gcc ata      816
Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu Ala Ile         
            260                 265                 270                 

ctt ctg gac aag act ctg agg aag gaa tgg ctc ctg gcc acc tcc aag      864
Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Lys         
        275                 280                 285                     

ccc ttc tct ttc tct cag ata gct gga gcc ata ctt ctg tgc atc atc      912
Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys Ile Ile         
    290                 295                 300                         

ttc agc ctc agc aac ata att tat ttc tca gct gct ctg tat cgg att      960
Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr Arg Ile         
305                 310                 315                 320         

ccc aag cca gaa tta cat aaa aaa gaa aca tga                          993
Pro Lys Pro Glu Leu His Lys Lys Glu Thr                                 
                325                 330                                 


<210>  10
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln Ile Pro 
1               5                   10                  15      


Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His Pro Gln 
            20                  25                  30          


Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr Asn Glu 
        35                  40                  45              


Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe Ala Trp 
    50                  55                  60                  


Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp Ser Tyr 
65                  70                  75                  80  


Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr Pro Leu 
                85                  90                  95      


Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg 
            100                 105                 110         


His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu 
        115                 120                 125             


Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala Leu Met 
    130                 135                 140                 


Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu Asn Thr 
145                 150                 155                 160 


Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Ile Gln 
                165                 170                 175     


Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala Tyr Pro 
            180                 185                 190         


Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu Phe Pro 
        195                 200                 205             


Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys His Met 
    210                 215                 220                 


Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu Pro Glu 
225                 230                 235                 240 


Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu 
                245                 250                 255     


Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu Ala Ile 
            260                 265                 270         


Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Lys 
        275                 280                 285             


Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys Ile Ile 
    290                 295                 300                 


Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr Arg Ile 
305                 310                 315                 320 


Pro Lys Pro Glu Leu His Lys Lys Glu Thr 
                325                 330 


<210>  11
<211>  1056
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  progestin and adipoQ receptor family member VI (PAQR6), 
       transcript variant 1, mRNA

<220>
<221>  CDS
<222>  (1)..(1056)

<400>  11
atg tcg ccc cgc atg cgc cac atc tgc tac ttc ctc gac tac ggc gcg       48
Met Ser Pro Arg Met Arg His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala         
1               5                   10                  15              

ctc agc ctc tac agt ctg ggc tgc gcc ttc ccc tat gcc gcc tac tcc       96
Leu Ser Leu Tyr Ser Leu Gly Cys Ala Phe Pro Tyr Ala Ala Tyr Ser         
            20                  25                  30                  

atg ccg gcc tcc tgg ctg cac ggc cac ctg cac cag ttc ttt gtg cct      144
Met Pro Ala Ser Trp Leu His Gly His Leu His Gln Phe Phe Val Pro         
        35                  40                  45                      

gcc gcc gca ctc aac tcc ttc ctg tgc acc ggc ctc tcc tgc tac tcc      192
Ala Ala Ala Leu Asn Ser Phe Leu Cys Thr Gly Leu Ser Cys Tyr Ser         
    50                  55                  60                          

cgt ttc ctg gag ctg gaa agc cct ggg ctc agt aag gtc ctc cgc aca      240
Arg Phe Leu Glu Leu Glu Ser Pro Gly Leu Ser Lys Val Leu Arg Thr         
65                  70                  75                  80          

gga gcc ttc gcc tat cca ttc ctg ttc gac aac ctc cca ctc ttt tat      288
Gly Ala Phe Ala Tyr Pro Phe Leu Phe Asp Asn Leu Pro Leu Phe Tyr         
                85                  90                  95              

cgg ctc ggg ctg tgc tgg ggc agg ggc cac ggc tgt ggg cag gag gcc      336
Arg Leu Gly Leu Cys Trp Gly Arg Gly His Gly Cys Gly Gln Glu Ala         
            100                 105                 110                 

ctg agc acc agc cat ggc tac cat ctc ttc tgc gcg ctg ctc act ggc      384
Leu Ser Thr Ser His Gly Tyr His Leu Phe Cys Ala Leu Leu Thr Gly         
        115                 120                 125                     

ttc ctc ttc gcc tcc cac ctg cct gaa agg ctg gca cca gga cgc ttt      432
Phe Leu Phe Ala Ser His Leu Pro Glu Arg Leu Ala Pro Gly Arg Phe         
    130                 135                 140                         

gat tac atc ggt gag ggc acg cct ggc ccg gcc cgg gaa gag gca ggg      480
Asp Tyr Ile Gly Glu Gly Thr Pro Gly Pro Ala Arg Glu Glu Ala Gly         
145                 150                 155                 160         

gca gat gcc ttc cca gag cac aga atg aac tgg gcc aca gcc acc agt      528
Ala Asp Ala Phe Pro Glu His Arg Met Asn Trp Ala Thr Ala Thr Ser         
                165                 170                 175             

tat tcc aca tct gtg cag tgc tgg gca ccc act tcc agc tgg agg cag      576
Tyr Ser Thr Ser Val Gln Cys Trp Ala Pro Thr Ser Ser Trp Arg Gln         
            180                 185                 190                 

tgc tgg ctg ata tgg gat cac gca gag cct ggc tgg cca cac agg aac      624
Cys Trp Leu Ile Trp Asp His Ala Glu Pro Gly Trp Pro His Arg Asn         
        195                 200                 205                     

ctg ccc tgg gcc tgg cag gca cag tgg cca cac tgg tct tgg ctg cag      672
Leu Pro Trp Ala Trp Gln Ala Gln Trp Pro His Trp Ser Trp Leu Gln         
    210                 215                 220                         

ctg gga acc tac tca tta ttg ctg ctt tca cag cca ccc tgc ttc ggg      720
Leu Gly Thr Tyr Ser Leu Leu Leu Leu Ser Gln Pro Pro Cys Phe Gly         
225                 230                 235                 240         

ccc cca gta cat gcc ctc tgc tgc agg gtg gcc cac tgg agg ggg gta      768
Pro Pro Val His Ala Leu Cys Cys Arg Val Ala His Trp Arg Gly Val         
                245                 250                 255             

ccc agg cca aac aac agt gag gcc cca tcc ctg acc ctg tcc tgg agg      816
Pro Arg Pro Asn Asn Ser Glu Ala Pro Ser Leu Thr Leu Ser Trp Arg         
            260                 265                 270                 

ggg cag agg cca ggc ccc agt gct gac gag gag ccc aga ttt ggg cct      864
Gly Gln Arg Pro Gly Pro Ser Ala Asp Glu Glu Pro Arg Phe Gly Pro         
        275                 280                 285                     

aat cag gtg ggg acg cat ctc agc ctg gaa cca aca ggg gct gag gag      912
Asn Gln Val Gly Thr His Leu Ser Leu Glu Pro Thr Gly Ala Glu Glu         
    290                 295                 300                         

aga ggg cac agg aga gag ggc aga gaa gag gag ggg tgt cta ggg gga      960
Arg Gly His Arg Arg Glu Gly Arg Glu Glu Glu Gly Cys Leu Gly Gly         
305                 310                 315                 320         

ctg gca gag tgt gag agg gac cgt gag ggg gct ctt gat ggg agt gga     1008
Leu Ala Glu Cys Glu Arg Asp Arg Glu Gly Ala Leu Asp Gly Ser Gly         
                325                 330                 335             

aga agt gct gag ggt ctg aga ggg gag atg cat gcg tgt cca ggc tga     1056
Arg Ser Ala Glu Gly Leu Arg Gly Glu Met His Ala Cys Pro Gly             
            340                 345                 350                 


<210>  12
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ser Pro Arg Met Arg His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala 
1               5                   10                  15      

Leu Ser Leu Tyr Ser Leu Gly Cys Ala Phe Pro Tyr Ala Ala Tyr Ser 
            20                  25                  30          

Met Pro Ala Ser Trp Leu His Gly His Leu His Gln Phe Phe Val Pro 
        35                  40                  45              

Ala Ala Ala Leu Asn Ser Phe Leu Cys Thr Gly Leu Ser Cys Tyr Ser 
    50                  55                  60                  

Arg Phe Leu Glu Leu Glu Ser Pro Gly Leu Ser Lys Val Leu Arg Thr 
65                  70                  75                  80  

Gly Ala Phe Ala Tyr Pro Phe Leu Phe Asp Asn Leu Pro Leu Phe Tyr 
                85                  90                  95      

Arg Leu Gly Leu Cys Trp Gly Arg Gly His Gly Cys Gly Gln Glu Ala 
            100                 105                 110         

Leu Ser Thr Ser His Gly Tyr His Leu Phe Cys Ala Leu Leu Thr Gly 
        115                 120                 125             

Phe Leu Phe Ala Ser His Leu Pro Glu Arg Leu Ala Pro Gly Arg Phe 
    130                 135                 140                 

Asp Tyr Ile Gly Glu Gly Thr Pro Gly Pro Ala Arg Glu Glu Ala Gly 
145                 150                 155                 160 

Ala Asp Ala Phe Pro Glu His Arg Met Asn Trp Ala Thr Ala Thr Ser 
                165                 170                 175     

Tyr Ser Thr Ser Val Gln Cys Trp Ala Pro Thr Ser Ser Trp Arg Gln 
            180                 185                 190         

Cys Trp Leu Ile Trp Asp His Ala Glu Pro Gly Trp Pro His Arg Asn 
        195                 200                 205             

Leu Pro Trp Ala Trp Gln Ala Gln Trp Pro His Trp Ser Trp Leu Gln 
    210                 215                 220                 

Leu Gly Thr Tyr Ser Leu Leu Leu Leu Ser Gln Pro Pro Cys Phe Gly 
225                 230                 235                 240 

Pro Pro Val His Ala Leu Cys Cys Arg Val Ala His Trp Arg Gly Val 
                245                 250                 255     

Pro Arg Pro Asn Asn Ser Glu Ala Pro Ser Leu Thr Leu Ser Trp Arg 
            260                 265                 270         

Gly Gln Arg Pro Gly Pro Ser Ala Asp Glu Glu Pro Arg Phe Gly Pro 
        275                 280                 285             


Asn Gln Val Gly Thr His Leu Ser Leu Glu Pro Thr Gly Ala Glu Glu 
    290                 295                 300                 

Arg Gly His Arg Arg Glu Gly Arg Glu Glu Glu Gly Cys Leu Gly Gly 
305                 310                 315                 320 

Leu Ala Glu Cys Glu Arg Asp Arg Glu Gly Ala Leu Asp Gly Ser Gly 
                325                 330                 335     

Arg Ser Ala Glu Gly Leu Arg Gly Glu Met His Ala Cys Pro Gly 
            340                 345                 350     


<210>  13
<211>  1041
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  progestin and adipoQ receptor family member VII, mRNA (cDNA clone
       MGC:22013 IMAGE:4400504)

<220>
<221>  CDS
<222>  (1)..(1041)

<400>  13
atg gcc atg gcc cag aaa ctc agc cac ctc ctg ccg agt ctg cgg cag       48
Met Ala Met Ala Gln Lys Leu Ser His Leu Leu Pro Ser Leu Arg Gln         
1               5                   10                  15              

gtc atc cag gag cct cag cta tct ctg cag cca gag cct gtc ttc acg       96
Val Ile Gln Glu Pro Gln Leu Ser Leu Gln Pro Glu Pro Val Phe Thr         
            20                  25                  30                  

gtg gat cga gct gag gtg ccg ccg ctc ttc tgg aag ccg tac atc tat      144
Val Asp Arg Ala Glu Val Pro Pro Leu Phe Trp Lys Pro Tyr Ile Tyr         
        35                  40                  45                      

gcg ggc tac cgg ccg ctg cat cag acc tgg cgc ttc tat ttc cgc acg      192
Ala Gly Tyr Arg Pro Leu His Gln Thr Trp Arg Phe Tyr Phe Arg Thr         
    50                  55                  60                          

ctg ttc cag cag cac aac gag gcc gtg aat gtc tgg acc cac ctg ctg      240
Leu Phe Gln Gln His Asn Glu Ala Val Asn Val Trp Thr His Leu Leu         
65                  70                  75                  80          

gcg gcc ctg gta ctg ctg ctg cgg ctg gcc ctc ttt gtg gag acc gtg      288
Ala Ala Leu Val Leu Leu Leu Arg Leu Ala Leu Phe Val Glu Thr Val         
                85                  90                  95              

gac ttc tgg gga gac cca cac gcc ctg ccc ctc ttc atc att gtc ctt      336
Asp Phe Trp Gly Asp Pro His Ala Leu Pro Leu Phe Ile Ile Val Leu         
            100                 105                 110                 

gcc tct ttc acc tac ctc tcc ttc agt gcc ttg gct cac ctc ctg cag      384
Ala Ser Phe Thr Tyr Leu Ser Phe Ser Ala Leu Ala His Leu Leu Gln         
        115                 120                 125                     

gcc aag tct gag ttc tgg cat tac agc ttc ttc ttc ctg gac tat gtg      432
Ala Lys Ser Glu Phe Trp His Tyr Ser Phe Phe Phe Leu Asp Tyr Val         
    130                 135                 140                         

ggg gtg gcc gtg tac cag ttt ggc agt gcc ttg gca cac ttc tac tat      480
Gly Val Ala Val Tyr Gln Phe Gly Ser Ala Leu Ala His Phe Tyr Tyr         
145                 150                 155                 160         

gct atc gag ccc gcc tgg cat gcc cag gtg cag gct gtt ttt ctg ccc      528
Ala Ile Glu Pro Ala Trp His Ala Gln Val Gln Ala Val Phe Leu Pro         
                165                 170                 175             

atg gct gcc ttt ctc gcc tgg ctt tcc tgc att ggc tcc tgc tat aac      576
Met Ala Ala Phe Leu Ala Trp Leu Ser Cys Ile Gly Ser Cys Tyr Asn         
            180                 185                 190                 

aag tac atc cag aaa cca ggc ctg ctg ggc cgc aca tgc cag gag gtg      624
Lys Tyr Ile Gln Lys Pro Gly Leu Leu Gly Arg Thr Cys Gln Glu Val         
        195                 200                 205                     

ccc tcc gtc ctg gcc tac gca ctg gac att agt cct gtg gtg cat cgt      672
Pro Ser Val Leu Ala Tyr Ala Leu Asp Ile Ser Pro Val Val His Arg         
    210                 215                 220                         

atc ttc atg tcc tcc gac ccc acc acg gat gat cca gct ctt ctc tac      720
Ile Phe Met Ser Ser Asp Pro Thr Thr Asp Asp Pro Ala Leu Leu Tyr         
225                 230                 235                 240         

cac aag tgc cag gtg gtc ttc ttt ctg ctg gct gct gcc ttc ttc tct      768
His Lys Cys Gln Val Val Phe Phe Leu Leu Ala Ala Ala Phe Phe Ser         
                245                 250                 255             

acc ttc atg ccc gag cgc tgg ttc cct ggc agc tgc cat gtc ttc ggg      816
Thr Phe Met Pro Glu Arg Trp Phe Pro Gly Ser Cys His Val Phe Gly         
            260                 265                 270                 

cag ggc cac caa ctt ttc cac atc ttc ttg gtg ctg tgc acg ctg gct      864
Gln Gly His Gln Leu Phe His Ile Phe Leu Val Leu Cys Thr Leu Ala         
        275                 280                 285                     

cag ctg gag gct gtg gca ctg gac tat gag gcc cga cgg ccc atc tat      912
Gln Leu Glu Ala Val Ala Leu Asp Tyr Glu Ala Arg Arg Pro Ile Tyr         
    290                 295                 300                         

gag cct ctg cac acg cac tgg cct cac aac ttt tct ggc ctc ttc ctg      960
Glu Pro Leu His Thr His Trp Pro His Asn Phe Ser Gly Leu Phe Leu         
305                 310                 315                 320         

ctc acg gtg ggc agc agc atc ctc act gca ttc ctc ctg agc cag ctg     1008
Leu Thr Val Gly Ser Ser Ile Leu Thr Ala Phe Leu Leu Ser Gln Leu         
                325                 330                 335             

gta cag cgc aaa ctt gat cag aag acc aag tga                         1041
Val Gln Arg Lys Leu Asp Gln Lys Thr Lys                                 
            340                 345                                     


<210>  14
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Ala Met Ala Gln Lys Leu Ser His Leu Leu Pro Ser Leu Arg Gln 
1               5                   10                  15      

Val Ile Gln Glu Pro Gln Leu Ser Leu Gln Pro Glu Pro Val Phe Thr 
            20                  25                  30          

Val Asp Arg Ala Glu Val Pro Pro Leu Phe Trp Lys Pro Tyr Ile Tyr 
        35                  40                  45              

Ala Gly Tyr Arg Pro Leu His Gln Thr Trp Arg Phe Tyr Phe Arg Thr 
    50                  55                  60                  

Leu Phe Gln Gln His Asn Glu Ala Val Asn Val Trp Thr His Leu Leu 
65                  70                  75                  80  

Ala Ala Leu Val Leu Leu Leu Arg Leu Ala Leu Phe Val Glu Thr Val 
                85                  90                  95      

Asp Phe Trp Gly Asp Pro His Ala Leu Pro Leu Phe Ile Ile Val Leu 
            100                 105                 110         

Ala Ser Phe Thr Tyr Leu Ser Phe Ser Ala Leu Ala His Leu Leu Gln 
        115                 120                 125             

Ala Lys Ser Glu Phe Trp His Tyr Ser Phe Phe Phe Leu Asp Tyr Val 
    130                 135                 140                 

Gly Val Ala Val Tyr Gln Phe Gly Ser Ala Leu Ala His Phe Tyr Tyr 
145                 150                 155                 160 

Ala Ile Glu Pro Ala Trp His Ala Gln Val Gln Ala Val Phe Leu Pro 
                165                 170                 175     

Met Ala Ala Phe Leu Ala Trp Leu Ser Cys Ile Gly Ser Cys Tyr Asn 
            180                 185                 190         

Lys Tyr Ile Gln Lys Pro Gly Leu Leu Gly Arg Thr Cys Gln Glu Val 
        195                 200                 205             

Pro Ser Val Leu Ala Tyr Ala Leu Asp Ile Ser Pro Val Val His Arg 
    210                 215                 220                 

Ile Phe Met Ser Ser Asp Pro Thr Thr Asp Asp Pro Ala Leu Leu Tyr 
225                 230                 235                 240 

His Lys Cys Gln Val Val Phe Phe Leu Leu Ala Ala Ala Phe Phe Ser 
                245                 250                 255     

Thr Phe Met Pro Glu Arg Trp Phe Pro Gly Ser Cys His Val Phe Gly 
            260                 265                 270         

Gln Gly His Gln Leu Phe His Ile Phe Leu Val Leu Cys Thr Leu Ala 
        275                 280                 285             


Gln Leu Glu Ala Val Ala Leu Asp Tyr Glu Ala Arg Arg Pro Ile Tyr 
    290                 295                 300                 

Glu Pro Leu His Thr His Trp Pro His Asn Phe Ser Gly Leu Phe Leu 
305                 310                 315                 320 

Leu Thr Val Gly Ser Ser Ile Leu Thr Ala Phe Leu Leu Ser Gln Leu 
                325                 330                 335     

Val Gln Arg Lys Leu Asp Gln Lys Thr Lys 
            340                 345     


<210>  15
<211>  1065
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  progestin and adipoQ receptor family member VIII (PAQR8), mRNA

<220>
<221>  CDS
<222>  (1)..(1065)

<400>  15
atg acg acc gcc atc ttg gag cgc ctg agc acc ctg tcg gtc agc ggg       48
Met Thr Thr Ala Ile Leu Glu Arg Leu Ser Thr Leu Ser Val Ser Gly         
1               5                   10                  15              

cag cag ctg cgc cgc ctg ccc aag atc ctg gag gat ggg ctt ccc aag       96
Gln Gln Leu Arg Arg Leu Pro Lys Ile Leu Glu Asp Gly Leu Pro Lys         
            20                  25                  30                  

atg cct tgc act gtc cca gaa acg gat gtg ccc cag ctc ttc cgg gag      144
Met Pro Cys Thr Val Pro Glu Thr Asp Val Pro Gln Leu Phe Arg Glu         
        35                  40                  45                      

cct tac atc cgc acc ggc tac cgc ccc acg ggg cac gag tgg cgc tac      192
Pro Tyr Ile Arg Thr Gly Tyr Arg Pro Thr Gly His Glu Trp Arg Tyr         
    50                  55                  60                          

tac ttc ttc agc ctc ttt cag aaa cac aac gag gtg gtc aac gtc tgg      240
Tyr Phe Phe Ser Leu Phe Gln Lys His Asn Glu Val Val Asn Val Trp         
65                  70                  75                  80          

acc cat tta ctg gca gcc ctg gcc gtc ctc ttg cga ttc tgg gcc ttt      288
Thr His Leu Leu Ala Ala Leu Ala Val Leu Leu Arg Phe Trp Ala Phe         
                85                  90                  95              

gcc gag gct gag gcc ttg cca tgg gcg tct acc cac tcc ctg cct ctg      336
Ala Glu Ala Glu Ala Leu Pro Trp Ala Ser Thr His Ser Leu Pro Leu         
            100                 105                 110                 

ctc ctc ttc atc ctg tcg tca atc act tac ctc acc tgc agc ctt ctg      384
Leu Leu Phe Ile Leu Ser Ser Ile Thr Tyr Leu Thr Cys Ser Leu Leu         
        115                 120                 125                     

gcc cac ctg ctg cag tcc aag tca gag ctc tcc cac tac acc ttc tac      432
Ala His Leu Leu Gln Ser Lys Ser Glu Leu Ser His Tyr Thr Phe Tyr         
    130                 135                 140                         

ttt gtg gac tat gtt ggc gtg agc gtt tac caa tat ggc agt gct ttg      480
Phe Val Asp Tyr Val Gly Val Ser Val Tyr Gln Tyr Gly Ser Ala Leu         
145                 150                 155                 160         

gct cat ttc ttc tac agc tct gac cag gcc tgg tat gac cgg ttc tgg      528
Ala His Phe Phe Tyr Ser Ser Asp Gln Ala Trp Tyr Asp Arg Phe Trp         
                165                 170                 175             

ctt ttc ttc ttg cca gca gct gcc ttc tgt ggc tgg tta tct tgt gct      576
Leu Phe Phe Leu Pro Ala Ala Ala Phe Cys Gly Trp Leu Ser Cys Ala         
            180                 185                 190                 

ggc tgt tgc tat gcc aaa tat cgt tac cgg agg cct tat cca gtc atg      624
Gly Cys Cys Tyr Ala Lys Tyr Arg Tyr Arg Arg Pro Tyr Pro Val Met         
        195                 200                 205                     

agg aag atc tgt caa gtg gtg cca gca ggt ctg gct ttt atc cta gac      672
Arg Lys Ile Cys Gln Val Val Pro Ala Gly Leu Ala Phe Ile Leu Asp         
    210                 215                 220                         

atc agc cct gtg gca cac cgt gtg gcg ctc tgt cac ctg gct ggc tgc      720
Ile Ser Pro Val Ala His Arg Val Ala Leu Cys His Leu Ala Gly Cys         
225                 230                 235                 240         

cag gag caa gca gcc tgg tac cac acc ctc cag atc ctc ttc ttc ctg      768
Gln Glu Gln Ala Ala Trp Tyr His Thr Leu Gln Ile Leu Phe Phe Leu         
                245                 250                 255             

gtt agc gct tat ttc ttc tcc tgc ccc gtg cct gag aag tac ttc ccg      816
Val Ser Ala Tyr Phe Phe Ser Cys Pro Val Pro Glu Lys Tyr Phe Pro         
            260                 265                 270                 

ggt tcc tgt gac atc gtg ggc cat ggg cat cag atc ttc cat gca ttt      864
Gly Ser Cys Asp Ile Val Gly His Gly His Gln Ile Phe His Ala Phe         
        275                 280                 285                     

ctg tcc atc tgt acg ctc tcc cag ctg gag gcc atc ctc ctg gac tac      912
Leu Ser Ile Cys Thr Leu Ser Gln Leu Glu Ala Ile Leu Leu Asp Tyr         
    290                 295                 300                         

cag ggg cgg cag gag atc ttc ctg cag cgc cat gga ccc cta tct gtc      960
Gln Gly Arg Gln Glu Ile Phe Leu Gln Arg His Gly Pro Leu Ser Val         
305                 310                 315                 320         

cac atg gcc tgc ctc tcc ttc ttc ttc ctg gct gcc tgc agt gct gcc     1008
His Met Ala Cys Leu Ser Phe Phe Phe Leu Ala Ala Cys Ser Ala Ala         
                325                 330                 335             

acc gca gcc ctt ctg agg cac aaa gtc aag gcc aga ctg acc aag aaa     1056
Thr Ala Ala Leu Leu Arg His Lys Val Lys Ala Arg Leu Thr Lys Lys         
            340                 345                 350                 

gat tcc tga                                                         1065
Asp Ser                                                                 
                                                                        


<210>  16
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Thr Ala Ile Leu Glu Arg Leu Ser Thr Leu Ser Val Ser Gly 
1               5                   10                  15      

Gln Gln Leu Arg Arg Leu Pro Lys Ile Leu Glu Asp Gly Leu Pro Lys 
            20                  25                  30          

Met Pro Cys Thr Val Pro Glu Thr Asp Val Pro Gln Leu Phe Arg Glu 
        35                  40                  45              

Pro Tyr Ile Arg Thr Gly Tyr Arg Pro Thr Gly His Glu Trp Arg Tyr 
    50                  55                  60                  

Tyr Phe Phe Ser Leu Phe Gln Lys His Asn Glu Val Val Asn Val Trp 
65                  70                  75                  80  

Thr His Leu Leu Ala Ala Leu Ala Val Leu Leu Arg Phe Trp Ala Phe 
                85                  90                  95      

Ala Glu Ala Glu Ala Leu Pro Trp Ala Ser Thr His Ser Leu Pro Leu 
            100                 105                 110         

Leu Leu Phe Ile Leu Ser Ser Ile Thr Tyr Leu Thr Cys Ser Leu Leu 
        115                 120                 125             

Ala His Leu Leu Gln Ser Lys Ser Glu Leu Ser His Tyr Thr Phe Tyr 
    130                 135                 140                 

Phe Val Asp Tyr Val Gly Val Ser Val Tyr Gln Tyr Gly Ser Ala Leu 
145                 150                 155                 160 

Ala His Phe Phe Tyr Ser Ser Asp Gln Ala Trp Tyr Asp Arg Phe Trp 
                165                 170                 175     

Leu Phe Phe Leu Pro Ala Ala Ala Phe Cys Gly Trp Leu Ser Cys Ala 
            180                 185                 190         

Gly Cys Cys Tyr Ala Lys Tyr Arg Tyr Arg Arg Pro Tyr Pro Val Met 
        195                 200                 205             

Arg Lys Ile Cys Gln Val Val Pro Ala Gly Leu Ala Phe Ile Leu Asp 
    210                 215                 220                 

Ile Ser Pro Val Ala His Arg Val Ala Leu Cys His Leu Ala Gly Cys 
225                 230                 235                 240 

Gln Glu Gln Ala Ala Trp Tyr His Thr Leu Gln Ile Leu Phe Phe Leu 
                245                 250                 255     

Val Ser Ala Tyr Phe Phe Ser Cys Pro Val Pro Glu Lys Tyr Phe Pro 
            260                 265                 270         


Gly Ser Cys Asp Ile Val Gly His Gly His Gln Ile Phe His Ala Phe 
        275                 280                 285             

Leu Ser Ile Cys Thr Leu Ser Gln Leu Glu Ala Ile Leu Leu Asp Tyr 
    290                 295                 300                 

Gln Gly Arg Gln Glu Ile Phe Leu Gln Arg His Gly Pro Leu Ser Val 
305                 310                 315                 320 

His Met Ala Cys Leu Ser Phe Phe Phe Leu Ala Ala Cys Ser Ala Ala 
                325                 330                 335     

Thr Ala Ala Leu Leu Arg His Lys Val Lys Ala Arg Leu Thr Lys Lys 
            340                 345                 350         


Asp Ser 
        


<210>  17
<211>  1134
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  progestin and adipoQ receptor family member IX (PAQR9), mRNA

<220>
<221>  CDS
<222>  (1)..(1134)

<400>  17
atg ccg cgg cgc ctg cag ccc cgg ggc gcg ggc aca aaa ggc cct ccg       48
Met Pro Arg Arg Leu Gln Pro Arg Gly Ala Gly Thr Lys Gly Pro Pro         
1               5                   10                  15              

gcc ccg gcc ccg gca gct tcg ggg gcc gcc cgg aac tcc cac tct gcc       96
Ala Pro Ala Pro Ala Ala Ser Gly Ala Ala Arg Asn Ser His Ser Ala         
            20                  25                  30                  

gcc tcc cgg gac ccc cca gcg tct gcc aag ccg ctg ctg cgc tgg gac      144
Ala Ser Arg Asp Pro Pro Ala Ser Ala Lys Pro Leu Leu Arg Trp Asp         
        35                  40                  45                      

gag gtg ccc gac gac ttc gtg gag tgc ttc atc ctg tcg ggc tac cgg      192
Glu Val Pro Asp Asp Phe Val Glu Cys Phe Ile Leu Ser Gly Tyr Arg         
    50                  55                  60                          

cgt ctg ccg tgc acg gcc cag gag tgc cta gcc tcg gtg ctg aag cct      240
Arg Leu Pro Cys Thr Ala Gln Glu Cys Leu Ala Ser Val Leu Lys Pro         
65                  70                  75                  80          

acc aac gag acg ctc aac ttc tgg acg cac ttc atc ccg ctg ctg ctg      288
Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Ile Pro Leu Leu Leu         
                85                  90                  95              

ttc ctg agc aag ttc tgc cgt ctg ttc ttc ctg agc ggc ggc gac gtg      336
Phe Leu Ser Lys Phe Cys Arg Leu Phe Phe Leu Ser Gly Gly Asp Val         
            100                 105                 110                 

ccc ttc cac cac ccg tgg ctg cta ccg ttg tgg tgc tac gcg tcg gga      384
Pro Phe His His Pro Trp Leu Leu Pro Leu Trp Cys Tyr Ala Ser Gly         
        115                 120                 125                     

gtg ctg ctg acc ttc gcc atg agc tgc acg gcg cac gtg ttc agc tgc      432
Val Leu Leu Thr Phe Ala Met Ser Cys Thr Ala His Val Phe Ser Cys         
    130                 135                 140                         

ctg tcg ctg cgt ctg cgc gcc gcc ttc ttc tac ctg gac tac gcg tcc      480
Leu Ser Leu Arg Leu Arg Ala Ala Phe Phe Tyr Leu Asp Tyr Ala Ser         
145                 150                 155                 160         

atc agc tac tac ggc ttc ggc agc acg gtg gcc tac tac tac tac ctg      528
Ile Ser Tyr Tyr Gly Phe Gly Ser Thr Val Ala Tyr Tyr Tyr Tyr Leu         
                165                 170                 175             

ttg cca ggc ctc agc ttg ctg gat gcc aga gtc atg act cca tac ttg      576
Leu Pro Gly Leu Ser Leu Leu Asp Ala Arg Val Met Thr Pro Tyr Leu         
            180                 185                 190                 

cag cag cgc ctg ggc tgg cac gtg gac tgc acg cgc ctt atc gcc gcc      624
Gln Gln Arg Leu Gly Trp His Val Asp Cys Thr Arg Leu Ile Ala Ala         
        195                 200                 205                     

tac cgc gcc ctg gtg ctg cct gtg gcc ttc gtg ctg gcg gtg gct tgc      672
Tyr Arg Ala Leu Val Leu Pro Val Ala Phe Val Leu Ala Val Ala Cys         
    210                 215                 220                         

act gtg gcc tgc tgc aag agc cgt acc gac tgg tgt acc tac ccg ttc      720
Thr Val Ala Cys Cys Lys Ser Arg Thr Asp Trp Cys Thr Tyr Pro Phe         
225                 230                 235                 240         

gcg ctg cgc acc ttc gtc ttc gtc atg ccg ctc agc atg gcc tgc ccc      768
Ala Leu Arg Thr Phe Val Phe Val Met Pro Leu Ser Met Ala Cys Pro         
                245                 250                 255             

att atg ctc gag agc tgg ctc ttc gac ctg cgt ggg gag aac ccc aca      816
Ile Met Leu Glu Ser Trp Leu Phe Asp Leu Arg Gly Glu Asn Pro Thr         
            260                 265                 270                 

ctc ttc gtg cac ttc tac cgc cgc tac ttc tgg ctg gtg gtg gcc gcc      864
Leu Phe Val His Phe Tyr Arg Arg Tyr Phe Trp Leu Val Val Ala Ala         
        275                 280                 285                     

ttc ttc aac gtg agc aag atc ccc gag cgc atc cag ccg ggt ctt ttc      912
Phe Phe Asn Val Ser Lys Ile Pro Glu Arg Ile Gln Pro Gly Leu Phe         
    290                 295                 300                         

gac att atc ggc cac agc cac cag ctc ttc cac atc ttc acc ttc ctc      960
Asp Ile Ile Gly His Ser His Gln Leu Phe His Ile Phe Thr Phe Leu         
305                 310                 315                 320         

agc atc tac gac cag gtg tac tac gta gaa gag ggc ctg cgc cag ttc     1008
Ser Ile Tyr Asp Gln Val Tyr Tyr Val Glu Glu Gly Leu Arg Gln Phe         
                325                 330                 335             

ctc cag gcg ccg cct gcc gca ccc act ttc tcg ggt act gtg ggc tac     1056
Leu Gln Ala Pro Pro Ala Ala Pro Thr Phe Ser Gly Thr Val Gly Tyr         
            340                 345                 350                 

atg ctg ctg ctg gtg gtc tgc ctg ggg ctg gta atc agg aag ttc cta     1104
Met Leu Leu Leu Val Val Cys Leu Gly Leu Val Ile Arg Lys Phe Leu         
        355                 360                 365                     

aac agc tcc gaa ttc tgc agt aaa aag tga                             1134
Asn Ser Ser Glu Phe Cys Ser Lys Lys                                     
    370                 375                                             


<210>  18
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Pro Arg Arg Leu Gln Pro Arg Gly Ala Gly Thr Lys Gly Pro Pro 
1               5                   10                  15      

Ala Pro Ala Pro Ala Ala Ser Gly Ala Ala Arg Asn Ser His Ser Ala 
            20                  25                  30          

Ala Ser Arg Asp Pro Pro Ala Ser Ala Lys Pro Leu Leu Arg Trp Asp 
        35                  40                  45              

Glu Val Pro Asp Asp Phe Val Glu Cys Phe Ile Leu Ser Gly Tyr Arg 
    50                  55                  60                  

Arg Leu Pro Cys Thr Ala Gln Glu Cys Leu Ala Ser Val Leu Lys Pro 
65                  70                  75                  80  

Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Ile Pro Leu Leu Leu 
                85                  90                  95      

Phe Leu Ser Lys Phe Cys Arg Leu Phe Phe Leu Ser Gly Gly Asp Val 
            100                 105                 110         

Pro Phe His His Pro Trp Leu Leu Pro Leu Trp Cys Tyr Ala Ser Gly 
        115                 120                 125             

Val Leu Leu Thr Phe Ala Met Ser Cys Thr Ala His Val Phe Ser Cys 
    130                 135                 140                 

Leu Ser Leu Arg Leu Arg Ala Ala Phe Phe Tyr Leu Asp Tyr Ala Ser 
145                 150                 155                 160 

Ile Ser Tyr Tyr Gly Phe Gly Ser Thr Val Ala Tyr Tyr Tyr Tyr Leu 
                165                 170                 175     

Leu Pro Gly Leu Ser Leu Leu Asp Ala Arg Val Met Thr Pro Tyr Leu 
            180                 185                 190         

Gln Gln Arg Leu Gly Trp His Val Asp Cys Thr Arg Leu Ile Ala Ala 
        195                 200                 205             


Tyr Arg Ala Leu Val Leu Pro Val Ala Phe Val Leu Ala Val Ala Cys 
    210                 215                 220                 

Thr Val Ala Cys Cys Lys Ser Arg Thr Asp Trp Cys Thr Tyr Pro Phe 
225                 230                 235                 240 

Ala Leu Arg Thr Phe Val Phe Val Met Pro Leu Ser Met Ala Cys Pro 
                245                 250                 255     


Ile Met Leu Glu Ser Trp Leu Phe Asp Leu Arg Gly Glu Asn Pro Thr 
            260                 265                 270         

Leu Phe Val His Phe Tyr Arg Arg Tyr Phe Trp Leu Val Val Ala Ala 
        275                 280                 285             

Phe Phe Asn Val Ser Lys Ile Pro Glu Arg Ile Gln Pro Gly Leu Phe 
    290                 295                 300                 

Asp Ile Ile Gly His Ser His Gln Leu Phe His Ile Phe Thr Phe Leu 
305                 310                 315                 320 

Ser Ile Tyr Asp Gln Val Tyr Tyr Val Glu Glu Gly Leu Arg Gln Phe 
                325                 330                 335     

Leu Gln Ala Pro Pro Ala Ala Pro Thr Phe Ser Gly Thr Val Gly Tyr 
            340                 345                 350         

Met Leu Leu Leu Val Val Cys Leu Gly Leu Val Ile Arg Lys Phe Leu 
        355                 360                 365             

Asn Ser Ser Glu Phe Cys Ser Lys Lys 
    370                 375         


<210>  19
<211>  741
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  monocyte to macrophage differentiation-associated 2 (MMD2), 
       transcript variant 2, mRNA

<220>
<221>  CDS
<222>  (1)..(741)

<400>  19
atg ttc gcc ccc cgg ctg ctg gat ttc cag aag acg aaa tac gcg agg       48
Met Phe Ala Pro Arg Leu Leu Asp Phe Gln Lys Thr Lys Tyr Ala Arg         
1               5                   10                  15              

ttc atg aac cac cga gtc cct gcc cac aag agg tac cag ccc aca gag       96
Phe Met Asn His Arg Val Pro Ala His Lys Arg Tyr Gln Pro Thr Glu         
            20                  25                  30                  

tat gaa cat gcg gcc aac tgt gcc acc cat gct ttc tgg atc atc ccc      144
Tyr Glu His Ala Ala Asn Cys Ala Thr His Ala Phe Trp Ile Ile Pro         
        35                  40                  45                      

agc atc ctg ggc agc tcc aac ctc tac ttc ctg tcg gac gat gac tgg      192
Ser Ile Leu Gly Ser Ser Asn Leu Tyr Phe Leu Ser Asp Asp Asp Trp         
    50                  55                  60                          

gag acc atc tct gcc tgg atc tac ggc ctc ggc ctc tgc ggc ctc ttc      240
Glu Thr Ile Ser Ala Trp Ile Tyr Gly Leu Gly Leu Cys Gly Leu Phe         
65                  70                  75                  80          

gtg gtg tcc act gtg ttt cac acc atc tcc tgg aag aag agc cac ctc      288
Val Val Ser Thr Val Phe His Thr Ile Ser Trp Lys Lys Ser His Leu         
                85                  90                  95              

agg atg gtg gaa cac tgt cta cac atg ttc gac cgg atg gtc atc tat      336
Arg Met Val Glu His Cys Leu His Met Phe Asp Arg Met Val Ile Tyr         
            100                 105                 110                 

ttc ttc ata gcg gct tcc tac gca ccc tgg ctg aac ctt cgg gag ctg      384
Phe Phe Ile Ala Ala Ser Tyr Ala Pro Trp Leu Asn Leu Arg Glu Leu         
        115                 120                 125                     

ggc ccc tgg gcc tcc cac atg cgc tgg ctg gtc tgg att atg gct tcc      432
Gly Pro Trp Ala Ser His Met Arg Trp Leu Val Trp Ile Met Ala Ser         
    130                 135                 140                         

gtg ggc acc atc tat gtc ttc ttc ttc cat gag cgg tac aag ctt gtg      480
Val Gly Thr Ile Tyr Val Phe Phe Phe His Glu Arg Tyr Lys Leu Val         
145                 150                 155                 160         

gag ctt ctc tgc tac gtc gta atg ggc ttc ttc ccc gcc ctg gtc atc      528
Glu Leu Leu Cys Tyr Val Val Met Gly Phe Phe Pro Ala Leu Val Ile         
                165                 170                 175             

ctc tcc atg ccc aac acc gag ggc atc tgg gag ctg gtg acc gga ggg      576
Leu Ser Met Pro Asn Thr Glu Gly Ile Trp Glu Leu Val Thr Gly Gly         
            180                 185                 190                 

gtc ttc tac tgc ctg ggc atg gtc ttc ttc aag agt gac ggg agg atc      624
Val Phe Tyr Cys Leu Gly Met Val Phe Phe Lys Ser Asp Gly Arg Ile         
        195                 200                 205                     

ccc ttt gcc cac gcc atc tgg cat ctc ttt gta gca ttt ggt gct ggt      672
Pro Phe Ala His Ala Ile Trp His Leu Phe Val Ala Phe Gly Ala Gly         
    210                 215                 220                         

acc cac tac tat gcc atc tgg agg tac ctc tat ctg ccc agc acc ctg      720
Thr His Tyr Tyr Ala Ile Trp Arg Tyr Leu Tyr Leu Pro Ser Thr Leu         
225                 230                 235                 240         

cag acc aag gtg tcc aaa tga                                          741
Gln Thr Lys Val Ser Lys                                                 
                245                                                     


<210>  20
<211>  246
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Phe Ala Pro Arg Leu Leu Asp Phe Gln Lys Thr Lys Tyr Ala Arg 
1               5                   10                  15      

Phe Met Asn His Arg Val Pro Ala His Lys Arg Tyr Gln Pro Thr Glu 
            20                  25                  30          

Tyr Glu His Ala Ala Asn Cys Ala Thr His Ala Phe Trp Ile Ile Pro 
        35                  40                  45              

Ser Ile Leu Gly Ser Ser Asn Leu Tyr Phe Leu Ser Asp Asp Asp Trp 
    50                  55                  60                  

Glu Thr Ile Ser Ala Trp Ile Tyr Gly Leu Gly Leu Cys Gly Leu Phe 
65                  70                  75                  80  

Val Val Ser Thr Val Phe His Thr Ile Ser Trp Lys Lys Ser His Leu 
                85                  90                  95      

Arg Met Val Glu His Cys Leu His Met Phe Asp Arg Met Val Ile Tyr 
            100                 105                 110         

Phe Phe Ile Ala Ala Ser Tyr Ala Pro Trp Leu Asn Leu Arg Glu Leu 
        115                 120                 125             

Gly Pro Trp Ala Ser His Met Arg Trp Leu Val Trp Ile Met Ala Ser 
    130                 135                 140                 

Val Gly Thr Ile Tyr Val Phe Phe Phe His Glu Arg Tyr Lys Leu Val 
145                 150                 155                 160 

Glu Leu Leu Cys Tyr Val Val Met Gly Phe Phe Pro Ala Leu Val Ile 
                165                 170                 175     

Leu Ser Met Pro Asn Thr Glu Gly Ile Trp Glu Leu Val Thr Gly Gly 
            180                 185                 190         

Val Phe Tyr Cys Leu Gly Met Val Phe Phe Lys Ser Asp Gly Arg Ile 
        195                 200                 205             

Pro Phe Ala His Ala Ile Trp His Leu Phe Val Ala Phe Gly Ala Gly 
    210                 215                 220                 

Thr His Tyr Tyr Ala Ile Trp Arg Tyr Leu Tyr Leu Pro Ser Thr Leu 
225                 230                 235                 240 

Gln Thr Lys Val Ser Lys 
                245     


<210>  21
<211>  717
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  monocyte to macrophage differentiation-associated (MMD), mRNA

<220>
<221>  CDS
<222>  (1)..(717)

<400>  21
atg cgg ttc aag aat cga ttc cag cgg ttc atg aac cat cga gct cca       48
Met Arg Phe Lys Asn Arg Phe Gln Arg Phe Met Asn His Arg Ala Pro         
1               5                   10                  15              

gcc aat ggc cgc tac aag cca act tgc tat gaa cat gct gct aac tgt       96
Ala Asn Gly Arg Tyr Lys Pro Thr Cys Tyr Glu His Ala Ala Asn Cys         
            20                  25                  30                  

tac aca cac gca ttc ctc att gtt ccg gcc atc gtg ggc agt gcc ctc      144
Tyr Thr His Ala Phe Leu Ile Val Pro Ala Ile Val Gly Ser Ala Leu         
        35                  40                  45                      

ctc cat cgg ctg tct gat gac tgc tgg gaa aag ata aca gca tgg att      192
Leu His Arg Leu Ser Asp Asp Cys Trp Glu Lys Ile Thr Ala Trp Ile         
    50                  55                  60                          

tat gga atg gga ctc tgt gcc ctc ttc atc gtt tct aca gta ttt cac      240
Tyr Gly Met Gly Leu Cys Ala Leu Phe Ile Val Ser Thr Val Phe His         
65                  70                  75                  80          

att gta tca tgg aaa aag agc cac tta agg aca gtg gag cat tgt ttt      288
Ile Val Ser Trp Lys Lys Ser His Leu Arg Thr Val Glu His Cys Phe         
                85                  90                  95              

cac atg tgt gat aga atg gtt atc tat ttc ttc att gct gct tct tat      336
His Met Cys Asp Arg Met Val Ile Tyr Phe Phe Ile Ala Ala Ser Tyr         
            100                 105                 110                 

gct cca tgg tta aat ctt cgt gaa ctt gga ccc ctg gca tct cat atg      384
Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ser His Met         
        115                 120                 125                     

cgt tgg ttt atc tgg ctc atg gca gct gga gga acc att tat gta ttt      432
Arg Trp Phe Ile Trp Leu Met Ala Ala Gly Gly Thr Ile Tyr Val Phe         
    130                 135                 140                         

ctc tac cat gaa aaa tat aag gtg gtt gaa ctc ttt ttc tat ctc aca      480
Leu Tyr His Glu Lys Tyr Lys Val Val Glu Leu Phe Phe Tyr Leu Thr         
145                 150                 155                 160         

atg gga ttc tct cca gcc ttg gtg gtg aca tca atg aac aac acc gat      528
Met Gly Phe Ser Pro Ala Leu Val Val Thr Ser Met Asn Asn Thr Asp         
                165                 170                 175             

gga ctt cag gaa ctt gcc tgt ggg ggc tta att tat tgc ttg gga gtt      576
Gly Leu Gln Glu Leu Ala Cys Gly Gly Leu Ile Tyr Cys Leu Gly Val         
            180                 185                 190                 

gtg ttc ttc aag agt gat ggc atc att cca ttt gcc cac gcc atc tgg      624
Val Phe Phe Lys Ser Asp Gly Ile Ile Pro Phe Ala His Ala Ile Trp         
        195                 200                 205                     

cac ctg ttt gtg gcc acg gca gct gca gtg cat tac tac gcc att tgg      672
His Leu Phe Val Ala Thr Ala Ala Ala Val His Tyr Tyr Ala Ile Trp         
    210                 215                 220                         

aaa tac ctt tac cga agt cct acg gac ttt atg cgg cat tta tga          717
Lys Tyr Leu Tyr Arg Ser Pro Thr Asp Phe Met Arg His Leu                 
225                 230                 235                             


<210>  22
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Arg Phe Lys Asn Arg Phe Gln Arg Phe Met Asn His Arg Ala Pro 
1               5                   10                  15      

Ala Asn Gly Arg Tyr Lys Pro Thr Cys Tyr Glu His Ala Ala Asn Cys 
            20                  25                  30          

Tyr Thr His Ala Phe Leu Ile Val Pro Ala Ile Val Gly Ser Ala Leu 
        35                  40                  45              

Leu His Arg Leu Ser Asp Asp Cys Trp Glu Lys Ile Thr Ala Trp Ile 
    50                  55                  60                  

Tyr Gly Met Gly Leu Cys Ala Leu Phe Ile Val Ser Thr Val Phe His 
65                  70                  75                  80  

Ile Val Ser Trp Lys Lys Ser His Leu Arg Thr Val Glu His Cys Phe 
                85                  90                  95      

His Met Cys Asp Arg Met Val Ile Tyr Phe Phe Ile Ala Ala Ser Tyr 
            100                 105                 110         

Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ser His Met 
        115                 120                 125             

Arg Trp Phe Ile Trp Leu Met Ala Ala Gly Gly Thr Ile Tyr Val Phe 
    130                 135                 140                 

Leu Tyr His Glu Lys Tyr Lys Val Val Glu Leu Phe Phe Tyr Leu Thr 
145                 150                 155                 160 

Met Gly Phe Ser Pro Ala Leu Val Val Thr Ser Met Asn Asn Thr Asp 
                165                 170                 175     

Gly Leu Gln Glu Leu Ala Cys Gly Gly Leu Ile Tyr Cys Leu Gly Val 
            180                 185                 190         

Val Phe Phe Lys Ser Asp Gly Ile Ile Pro Phe Ala His Ala Ile Trp 
        195                 200                 205             

His Leu Phe Val Ala Thr Ala Ala Ala Val His Tyr Tyr Ala Ile Trp 
    210                 215                 220                 

Lys Tyr Leu Tyr Arg Ser Pro Thr Asp Phe Met Arg His Leu 
225                 230                 235             


<210>  23
<211>  954
<212>  DNA
<213>  Saccharomyces cerevisiae


<220>
<221>  misc_feature
<223>  chromosome XV, complete chromosome sequence.

<220>
<221>  CDS
<222>  (1)..(954)

<400>  23
cta gga gac aat ccc gtt ctc cat ctt tat atg gac taa ctc ata act       48
Leu Gly Asp Asn Pro Val Leu His Leu Tyr Met Asp     Leu Ile Thr         
1               5                   10                      15          

att taa taa acc tct caa gtg gca caa tgc cgc aat aac aac tag aaa       96
Ile         Thr Ser Gln Val Ala Gln Cys Arg Asn Asn Asn     Lys         
                        20                  25                          

atg gaa aag ttg gtg aga atg acc cca aat atc aaa ttt acc ggg gca      144
Met Glu Lys Leu Val Arg Met Thr Pro Asn Ile Lys Phe Thr Gly Ala         
    30                  35                  40                          

aat ctt ttc agg aaa ccg cat tcc ata aag aac agc gcc aat tat ata      192
Asn Leu Phe Arg Lys Pro His Ser Ile Lys Asn Ser Ala Asn Tyr Ile         
45                  50                  55                  60          

tag gac acc ccc aag taa tac cca aaa gag ctg aat ttg ggt cca aat      240
    Asp Thr Pro Lys     Tyr Pro Lys Glu Leu Asn Leu Gly Pro Asn         
                        65                  70                          

ttc tga aaa act ata gca gta aag gcc gct gaa tat tgg aat aat tga      288
Phe     Lys Thr Ile Ala Val Lys Ala Ala Glu Tyr Trp Asn Asn             
75                      80                  85                          

gga taa acc aaa aca aac aaa tag ccc agc tct gta agg tct cca ctc      336
Gly     Thr Lys Thr Asn Lys     Pro Ser Ser Val Arg Ser Pro Leu         
        90                      95                  100                 

tct ttt ccg aaa ctt atc ttt tag tga cac aat act aca cgc gat ccc      384
Ser Phe Pro Lys Leu Ile Phe         His Asn Thr Thr Arg Asp Pro         
        105                         110                 115             

aaa gct aac ggt aat aag cgc aaa tag gca aaa tag gga aaa ttt ctc      432
Lys Ala Asn Gly Asn Lys Arg Lys     Ala Lys     Gly Lys Phe Leu         
            120                     125                     130         

aaa ata gcc gta gta caa aat act gac cat tga cgt aac aat caa tat      480
Lys Ile Ala Val Val Gln Asn Thr Asp His     Arg Asn Asn Gln Tyr         
                135                 140                     145         

aca aat acc aag gta gtc caa ctt att tcc taa ggt agc aat tct taa      528
Thr Asn Thr Lys Val Val Gln Leu Ile Ser     Gly Ser Asn Ser             
                150                 155                                 

gga gtg act ctt tag aca atg aaa gga gct act caa tat taa aca tgc      576
Gly Val Thr Leu     Thr Met Lys Gly Ala Thr Gln Tyr     Thr Cys         
160                     165                 170                         

aaa cgc ccc cga ata aaa gag gtc gat tac cat atg atc tag cca tgt      624
Lys Arg Pro Arg Ile Lys Glu Val Asp Tyr His Met Ile     Pro Cys         
    175                 180                 185                         

agt tgt tgc aaa cac ttt gat agt aga ttt atc tag caa cag tac agt      672
Ser Cys Cys Lys His Phe Asp Ser Arg Phe Ile     Gln Gln Tyr Ser         
    190                 195                     200                     

gaa gaa ccc gag agc agg aat taa atg tga ata aat att gac act ttc      720
Glu Glu Pro Glu Ser Arg Asn     Met     Ile Asn Ile Asp Thr Phe         
    205                 210                         215                 

att atg caa ata aaa caa act ttt aaa agt ttc aat gaa gct act agt      768
Ile Met Gln Ile Lys Gln Thr Phe Lys Ser Phe Asn Glu Ala Thr Ser         
        220                 225                 230                     

ttc ttt cac gta tcc atg taa aat aaa atc att gtc tct ttg cca ttc      816
Phe Phe His Val Ser Met     Asn Lys Ile Ile Val Ser Leu Pro Phe         
    235                     240                 245                     

cgg aat ttc atc cca act ata tag cct tct tag tac ttt ttt agc ttt      864
Arg Asn Phe Ile Pro Thr Ile     Pro Ser     Tyr Phe Phe Ser Phe         
    250                 255                         260                 

agc gac ctc tgc ggg att tgc gga tgt ttt ccc tgc agc tct ctt ctt      912
Ser Asp Leu Cys Gly Ile Cys Gly Cys Phe Pro Cys Ser Ser Leu Leu         
        265                 270                 275                     

cag ctc ttg cac act ctt agt cct ttc taa taa agt tga cat              954
Gln Leu Leu His Thr Leu Ser Pro Phe         Ser     His                 
    280                 285                                             


<210>  24
<211>  12
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  24

Leu Gly Asp Asn Pro Val Leu His Leu Tyr Met Asp 
1               5                   10          


<210>  25
<211>  4
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  25

Leu Ile Thr Ile 
1               


<210>  26
<211>  11
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  26

Thr Ser Gln Val Ala Gln Cys Arg Asn Asn Asn 
1               5                   10      


<210>  27
<211>  33
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  27

Lys Met Glu Lys Leu Val Arg Met Thr Pro Asn Ile Lys Phe Thr Gly 
1               5                   10                  15      

Ala Asn Leu Phe Arg Lys Pro His Ser Ile Lys Asn Ser Ala Asn Tyr 
            20                  25                  30          


Ile 
    


<210>  28
<211>  4
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  28

Asp Thr Pro Lys 
1               


<210>  29
<211>  11
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  29

Tyr Pro Lys Glu Leu Asn Leu Gly Pro Asn Phe 
1               5                   10      


<210>  30
<211>  13
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  30

Lys Thr Ile Ala Val Lys Ala Ala Glu Tyr Trp Asn Asn 
1               5                   10              


<210>  31
<211>  5
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  31

Thr Lys Thr Asn Lys 
1               5   


<210>  32
<211>  15
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  32

Pro Ser Ser Val Arg Ser Pro Leu Ser Phe Pro Lys Leu Ile Phe 
1               5                   10                  15  


<210>  33
<211>  15
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  33

His Asn Thr Thr Arg Asp Pro Lys Ala Asn Gly Asn Lys Arg Lys 
1               5                   10                  15  


<210>  34
<211>  14
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  34

Gly Lys Phe Leu Lys Ile Ala Val Val Gln Asn Thr Asp His 
1               5                   10                  


<210>  35
<211>  15
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  35

Arg Asn Asn Gln Tyr Thr Asn Thr Lys Val Val Gln Leu Ile Ser 
1               5                   10                  15  


<210>  36
<211>  4
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  36

Gly Ser Asn Ser 
1               


<210>  37
<211>  4
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  37

Gly Val Thr Leu 
1               


<210>  38
<211>  8
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  38

Thr Met Lys Gly Ala Thr Gln Tyr 
1               5               


<210>  39
<211>  15
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  39

Thr Cys Lys Arg Pro Arg Ile Lys Glu Val Asp Tyr His Met Ile 
1               5                   10                  15  


<210>  40
<211>  13
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  40

Pro Cys Ser Cys Cys Lys His Phe Asp Ser Arg Phe Ile 
1               5                   10              


<210>  41
<211>  11
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  41

Gln Gln Tyr Ser Glu Glu Pro Glu Ser Arg Asn 
1               5                   10      


<210>  42
<211>  28
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  42

Ile Asn Ile Asp Thr Phe Ile Met Gln Ile Lys Gln Thr Phe Lys Ser 
1               5                   10                  15      


Phe Asn Glu Ala Thr Ser Phe Phe His Val Ser Met 
            20                  25              


<210>  43
<211>  16
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  43

Asn Lys Ile Ile Val Ser Leu Pro Phe Arg Asn Phe Ile Pro Thr Ile 
1               5                   10                  15      


<210>  44
<211>  30
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  44

Tyr Phe Phe Ser Phe Ser Asp Leu Cys Gly Ile Cys Gly Cys Phe Pro 
1               5                   10                  15      


Cys Ser Ser Leu Leu Gln Leu Leu His Thr Leu Ser Pro Phe 
            20                  25                  30  


<210>  45
<211>  375
<212>  PRT
<213>  Monodelphis domestica

<400>  45

Met Ser Ser Ser Lys Gly Ser Ala Val Gly Pro Gly Asn Gly Ala Pro 
1               5                   10                  15      

Ala Ser Asn Arg Glu Thr Asp Thr Val Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          

Leu Leu Ile Glu Lys Gly Lys Arg Met Thr Pro Ser Ser Thr Lys Val 
        35                  40                  45              


Glu Glu Glu Gln Thr Cys Pro Val Pro Gln Glu Glu Glu Glu Glu Val 
    50                  55                  60                  

Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  

Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      

Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         

Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             

Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 

Phe Val Leu Phe Leu Phe Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 

Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     

Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         

Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             

Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 

Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 

Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     

Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         

Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             

Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 

Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 

Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     

His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         

Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             


Cys Thr Asp Asp Ser Leu Leu 
    370                 375 


<210>  46
<211>  375
<212>  PRT
<213>  Gallus gallus

<400>  46

Met Ala Ser Arg Lys Ala Ala Ala Ala Ala Gln Gly Asn Gly Leu Ala 
1               5                   10                  15      

Ala Ala Gly Arg Asp Arg Ala His Leu Glu Leu Ala Glu Leu Gly Pro 
            20                  25                  30          

Leu Leu Glu Glu Lys Gly Glu Gln Gly Ala Ala Gly Thr Ala Ser Ala 
        35                  40                  45              

Glu Asp Pro Pro Cys Pro Val Ala Arg Glu Glu Glu Glu Glu Val Val 
    50                  55                  60                  

Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  

Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      

Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         

Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
        115                 120                 125             

Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 

Phe Val Leu Phe Leu Cys Leu Gly Ile Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 

Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     

Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         

Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             

Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 

Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Ser 
225                 230                 235                 240 

Ile Val Cys Val Leu Gly Ile Ser Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     


Arg Phe Ala Thr Pro Lys His Arg Gln Thr Arg Ala Gly Val Phe Leu 
            260                 265                 270         

Gly Leu Gly Leu Ser Gly Val Val Pro Thr Met His Phe Thr Ile Ala 
        275                 280                 285             

Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Phe 
    290                 295                 300                 

Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 

Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp Phe Gln Ser 
                325                 330                 335     

His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Val His Phe 
            340                 345                 350         

Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             

Cys Thr Asp Asp Ser Leu Leu 
    370                 375 


<210>  47
<211>  378
<212>  PRT
<213>  Xenopus tropicalis

<400>  47

Met Ala Thr Cys Lys Pro Leu Ser Ser Gly Gln Glu Ser Ala Leu Ser 
1               5                   10                  15      

Ser Ser Ser Ser Arg Gly Glu Thr Asp Asp Leu Glu Leu Ala Glu Leu 
            20                  25                  30          

Gly Pro Leu Leu Glu Ala Arg Arg Glu Arg Ile Gly Gln Thr Ser Ser 
        35                  40                  45              

Gly Asp Glu Asn Gln Ala Ser Lys Val Ser Pro Glu Glu Glu Glu Glu 
    50                  55                  60                  

Glu Glu Val Arg Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met 
65                  70                  75                  80  

Glu Lys Met Glu Glu Phe Val Tyr Lys Val Trp Glu Gly Arg Trp Arg 
                85                  90                  95      

Val Ile Pro Tyr Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr 
            100                 105                 110         

Leu Leu His Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe 
        115                 120                 125             

Arg Ser Ile Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His 
    130                 135                 140                 


Leu Leu Gly Phe Val Leu Phe Leu Ser Leu Gly Val Leu Thr Met Leu 
145                 150                 155                 160 

Arg Pro Asn Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe 
                165                 170                 175     

Gly Met Phe Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu 
            180                 185                 190         

Phe His Thr Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser 
        195                 200                 205             

Lys Leu Asp Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val 
    210                 215                 220                 

Pro Trp Leu Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile 
225                 230                 235                 240 

Tyr Leu Ser Ile Val Cys Val Leu Gly Ile Thr Ala Ile Val Val Ala 
                245                 250                 255     

Gln Trp Asp Arg Phe Ala Thr Pro Lys His Arg Pro Thr Arg Ala Gly 
            260                 265                 270         

Val Phe Leu Gly Leu Gly Leu Ser Gly Ile Val Pro Thr Leu His Phe 
        275                 280                 285             

Thr Ile Ala Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly 
    290                 295                 300                 

Trp Phe Phe Leu Met Ala Val Met Tyr Ile Thr Gly Ala Gly Leu Tyr 
305                 310                 315                 320 

Ala Ala Arg Ile Pro Glu Arg Phe Phe Pro Gly Lys Phe Asp Ile Trp 
                325                 330                 335     

Phe Gln Ser His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe 
            340                 345                 350         

Ile His Phe Tyr Gly Ile Ser Asn Leu Gln Glu Phe Arg Tyr Ala Leu 
        355                 360                 365             

Glu Gly Gly Cys Thr Asp Asp Ser Leu Leu 
    370                 375             


<210>  48
<211>  377
<212>  PRT
<213>  Danio rerio

<400>  48

Met Thr Thr Cys His His Gly Asp Cys Gly Ser Asn Ser Asp Ala Glu 
1               5                   10                  15      

Arg Arg Ala Thr Asp Asp Glu Ala Asn Met Glu Asp Ala Glu Leu Ser 
            20                  25                  30          


Glu Leu Gly Pro Leu Leu Thr Ser Pro Ala Asn Ser Glu Glu Ser Arg 
        35                  40                  45              

Gly Ala Ser Ala Ser Pro Asp Glu Asn Glu Asp Glu Lys Glu Glu Gly 
    50                  55                  60                  

Gly Leu Arg Val Val Thr Leu Pro Met Gln Ala His His Ala Met Glu 
65                  70                  75                  80  

Lys Met Glu Glu Phe Val His Lys Ile Trp Glu Gly His Trp Arg Val 
                85                  90                  95      

Ile Pro Tyr His Leu Leu Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu 
            100                 105                 110         

Leu His Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Gly 
        115                 120                 125             

Ser Ile Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu 
    130                 135                 140                 

Leu Gly Leu Ile Leu Phe Leu Cys Leu Gly Thr Leu Thr Met Leu Arg 
145                 150                 155                 160 

Pro Asn Val Ser Phe Met Ala Pro Val Gln Glu Lys Val Val Phe Gly 
                165                 170                 175     

Val Phe Phe Leu Gly Ala Val Leu Cys Leu Cys Phe Ser Trp Leu Phe 
            180                 185                 190         

His Thr Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys 
        195                 200                 205             

Leu Asp Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro 
    210                 215                 220                 

Trp Leu Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr 
225                 230                 235                 240 

Leu Ser Val Val Cys Val Leu Gly Val Ala Ala Ile Ile Val Ala Gln 
                245                 250                 255     

Trp Asp Arg Phe Ala Thr Pro Arg His Arg Ser Thr Arg Ala Gly Val 
            260                 265                 270         

Phe Leu Gly Leu Gly Leu Ser Gly Leu Val Pro Thr Met His Phe Thr 
        275                 280                 285             

Ile Ala Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp 
    290                 295                 300                 

Phe Tyr Leu Met Gly Ala Met Tyr Ile Ser Gly Ala Ala Leu Tyr Ala 
305                 310                 315                 320 

Ala Arg Ile Pro Glu Arg Tyr Phe Pro Gly Arg Cys Asp Ile Trp Phe 
                325                 330                 335     

Gln Ser His Gln Ile Phe His Val Leu Val Val Gly Ala Ala Phe Val 
            340                 345                 350         


His Phe Tyr Gly Ile Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu 
        355                 360                 365             

Gly Gly Cys Thr Asp Asp Thr Leu Leu 
    370                 375         


<210>  49
<211>  375
<212>  PRT
<213>  Danio rerio

<400>  49

Met Ser Gly Gln Ile Arg Ser Ala Ser His Ala Asp Cys Arg Val Thr 
1               5                   10                  15      

Glu Glu Cys His Val Pro Ala Asp Val Glu Leu Met Glu Leu Gly Pro 
            20                  25                  30          

Leu Leu Glu Glu Asn Gly Pro Met Gly Ala Lys Gly Leu Gln Ser Glu 
        35                  40                  45              

Gly Ala Gly Ala Leu Ala Asp Asp Glu Glu Glu Asp Glu Glu Val Gly 
    50                  55                  60                  

Glu Val Leu Thr Leu Pro Leu Gln Ala His His Ala Met Glu Lys Met 
65                  70                  75                  80  

Glu Glu Phe Val His Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
                85                  90                  95      

Phe His Val Leu Pro Glu Trp Leu Lys Asp Asn Asp Tyr Leu Leu His 
            100                 105                 110         

Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Gly Ser Ile 
        115                 120                 125             

Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
    130                 135                 140                 

Leu Ile Leu Phe Leu Cys Leu Gly Thr Leu Thr Met Leu Arg Pro Asn 
145                 150                 155                 160 

Met Tyr Phe Met Ala Pro Leu Gln Glu Lys Val Val Phe Gly Met Phe 
                165                 170                 175     

Phe Leu Gly Ala Val Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
            180                 185                 190         

Val Tyr Cys His Ser Glu Lys Val Ser Arg Thr Phe Ser Lys Leu Asp 
        195                 200                 205             

Tyr Ser Gly Ile Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
    210                 215                 220                 

Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Arg Leu Ile Tyr Leu Thr 
225                 230                 235                 240 


Ile Val Cys Val Leu Gly Ile Ala Ala Ile Ile Val Ala Gln Trp Asp 
                245                 250                 255     

Arg Phe Ser Thr Pro Arg His Arg Pro Thr Arg Ala Gly Val Phe Met 
            260                 265                 270         

Ser Leu Gly Leu Ser Gly Ile Val Pro Thr Met His Phe Thr Ile Glu 
        275                 280                 285             

Glu Gly Phe Val Lys Ala Thr Thr Val Gly Gln Met Gly Trp Phe Tyr 
    290                 295                 300                 

Leu Met Gly Ala Met Tyr Ile Thr Gly Ala Gly Leu Tyr Ala Ala Arg 
305                 310                 315                 320 

Ile Pro Glu Arg Tyr Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser 
                325                 330                 335     

His Gln Ile Phe His Val Leu Val Val Ala Ala Ala Phe Ile His Phe 
            340                 345                 350         

Tyr Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Gly Leu Glu Gly Gly 
        355                 360                 365             

Cys Thr Asp Asp Thr Leu Leu 
    370                 375 


<210>  50
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Asn Glu Pro Thr Glu Asn Arg Leu Gly Cys Ser Arg Thr Pro Glu 
1               5                   10                  15      

Pro Asp Ile Arg Leu Arg Lys Gly His Gln Leu Asp Gly Thr Arg Arg 
            20                  25                  30          

Gly Asp Asn Asp Ser His Gln Gly Asp Leu Glu Pro Ile Leu Glu Ala 
        35                  40                  45              

Ser Val Leu Ser Ser His His Lys Lys Ser Ser Glu Glu His Glu Tyr 
    50                  55                  60                  

Ser Asp Glu Ala Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro 
65                  70                  75                  80  

Leu Leu Gln Ala His His Ala Met Glu Lys Met Glu Glu Phe Val Cys 
                85                  90                  95      

Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro 
            100                 105                 110         

Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro Pro 
        115                 120                 125             


Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr 
    130                 135                 140                 

Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Ser Phe Leu 
145                 150                 155                 160 

Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val Ala 
                165                 170                 175     

Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala Ile 
            180                 185                 190         

Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser 
        195                 200                 205             

Glu Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala 
    210                 215                 220                 

Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr 
225                 230                 235                 240 

Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu 
                245                 250                 255     

Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro 
            260                 265                 270         

Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser 
        275                 280                 285             

Gly Ile Ile Pro Thr Leu His Tyr Val Ile Ser Glu Gly Phe Leu Lys 
    290                 295                 300                 

Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Met Leu Met Ala Ser Leu 
305                 310                 315                 320 

Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe 
                325                 330                 335     

Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His 
            340                 345                 350         

Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn 
        355                 360                 365             

Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu Asp 
    370                 375                 380                 


Ala Leu 
385     


<210>  51
<211>  387
<212>  PRT
<213>  Monodelphis domestica

<400>  51

Met Asn Glu Thr Ala Asp Leu Val Ser Gly Cys Asn Ser Thr Pro Glu 
1               5                   10                  15      

Pro Val Ile Arg Leu Arg Lys Gly Tyr Gln Ser Asp Val Ser Ala Lys 
            20                  25                  30          

Gly His Asn Asp Asn His Gln Gly Glu Asp Leu Gly Pro Asp Leu Ala 
        35                  40                  45              

Ala Ser Ile Pro Cys Ser Tyr Phe Lys Asn Lys Ser Glu Glu His Asp 
    50                  55                  60                  

Cys Asn His Gly Gln Ser Gln Glu Asp Glu Gly Phe Met Ala Met Ser 
65                  70                  75                  80  

Pro Leu Leu Gln Ala His His Ala Met Glu Arg Met Glu Glu Phe Val 
                85                  90                  95      

Cys Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu 
            100                 105                 110         

Pro Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His Gly His Arg Pro 
        115                 120                 125             

Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His 
    130                 135                 140                 


Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe 
145                 150                 155                 160 

Leu Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Ile Ser Phe Val 
                165                 170                 175     

Ala Pro Leu Gln Glu Lys Val Val Phe Gly Leu Phe Phe Leu Gly Ala 
            180                 185                 190         

Ile Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His 
        195                 200                 205             

Ser Glu Ala Val Ser Arg Ile Phe Ser Lys Leu Asp Tyr Ser Gly Ile 
    210                 215                 220                 

Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe 
225                 230                 235                 240 

Tyr Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val 
                245                 250                 255     

Leu Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr 
            260                 265                 270         

Pro Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu 
        275                 280                 285             

Ser Gly Ile Ile Pro Thr Leu His Tyr Val Phe Ser Glu Gly Phe Leu 
    290                 295                 300                 


Lys Ala Ala Thr Ile Gly Gln Ile Gly Trp Leu Leu Leu Met Ala Cys 
305                 310                 315                 320 

Leu Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg 
                325                 330                 335     

Phe Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe 
            340                 345                 350         

His Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser 
        355                 360                 365             

Asn Leu Gln Glu Phe Arg Phe Met Ile Gly Gly Gly Cys Ser Glu Glu 
    370                 375                 380                 


Asp Ala Leu 
385         


<210>  52
<211>  386
<212>  PRT
<213>  Gallus gallus

<400>  52

Met Asn Glu Leu Thr Glu Leu Asp Asn Ala Gly Ser Pro Glu Pro Gly 
1               5                   10                  15      

Leu Arg Leu Arg Lys Gly His Met Ser Asp Ser Ala Thr Thr Gln Thr 
            20                  25                  30          

Ala Phe Glu Glu Asp Ser Ser Glu Gln Arg Leu Leu Leu Val Glu Pro 
        35                  40                  45              

Pro Leu Ser Ser Asn Gln Glu Asn Ser Ser Glu Asp Ser Asn His Asn 
    50                  55                  60                  

Asp Glu Ser Pro Gln Glu Asp Glu Gly Phe Met Gly Met Ser Pro Leu 
65                  70                  75                  80  

Leu Gln Ala His His Ala Met Glu Arg Met Glu Glu Phe Val Cys Lys 
                85                  90                  95      

Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu Pro Asp 
            100                 105                 110         

Trp Leu Lys Asp Asn Asp Tyr Leu Leu His Gly His Arg Pro Pro Met 
        115                 120                 125             

Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His Thr Glu 
    130                 135                 140                 

Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe Leu Cys 
145                 150                 155                 160 

Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Met Ser Phe Val Ala Pro 
                165                 170                 175     


Val Gln Glu Lys Val Val Val Gly Leu Phe Phe Leu Gly Ala Ile Leu 
            180                 185                 190         

Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His Ser Glu 
        195                 200                 205             

Gly Val Ser Arg Leu Phe Ser Lys Leu Asp Tyr Ser Gly Ile Ala Leu 
    210                 215                 220                 

Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe Tyr Cys 
225                 230                 235                 240 

Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Val Ile Cys Val Leu Gly 
                245                 250                 255     

Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Met Phe Ala Thr Pro Gln 
            260                 265                 270         

Tyr Arg Gly Val Arg Ala Gly Val Phe Leu Gly Leu Gly Leu Ser Gly 
        275                 280                 285             

Val Ile Pro Thr Leu His Phe Val Ile Ser Glu Gly Leu Leu Lys Ala 
    290                 295                 300                 

Ala Thr Met Gly Gln Ile Gly Trp Leu Ala Leu Met Ala Cys Leu Tyr 
305                 310                 315                 320 

Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg Phe Phe 
                325                 330                 335     

Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe His Val 
            340                 345                 350         

Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser Asn Leu 
        355                 360                 365             

Gln Glu Phe Arg Phe Thr Val Gly Gly Gly Cys Thr Glu Glu Glu Gly 
    370                 375                 380                 

Met Gln 
385     


<210>  53
<211>  387
<212>  PRT
<213>  Xenopus tropicalis

<400>  53

Met Asn Thr Gln Glu Asn Glu Gln Glu Gly Cys Ser Thr Gly Pro Glu 
1               5                   10                  15      

Ser Val Leu Arg Leu Arg Lys Gly His Met Pro Val Thr Ser Glu Glu 
            20                  25                  30          

Thr Asp Ser Gln His Glu Gln Phe Asp His Leu Cys Pro Leu Leu Ala 
        35                  40                  45              


Asp Pro Pro Pro Cys Pro Ala Gln Asp Asn Asn Val Glu Glu Asn Glu 
    50                  55                  60                  

Ser Thr Glu Glu Pro Ala Gln Glu Asp Glu Gly Phe Met Gly Met Ala 
65                  70                  75                  80  

Pro Leu Leu Gln Ala His His Ala Met Glu Arg Val Glu Glu Phe Val 
                85                  90                  95      

Cys Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro His Asp Val Leu 
            100                 105                 110         

Pro Asp Trp Leu Lys Asp Asn Asp Tyr Leu Leu His Gly His Arg Pro 
        115                 120                 125             

Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile Phe Arg Ile His 
    130                 135                 140                 

Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly Cys Val Phe Phe 
145                 150                 155                 160 

Leu Cys Leu Gly Ile Phe Tyr Met Phe Arg Pro Asn Met Ala Phe Ile 
                165                 170                 175     

Ala Pro Val Gln Glu Lys Val Val Phe Gly Met Phe Phe Leu Gly Ala 
            180                 185                 190         


Ile Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr Val Tyr Cys His 
        195                 200                 205             

Ser Glu Gly Val Ser Arg Val Phe Ser Lys Leu Asp Tyr Ser Gly Ile 
    210                 215                 220                 

Ala Leu Leu Ile Met Gly Ser Phe Val Pro Trp Leu Tyr Tyr Ser Phe 
225                 230                 235                 240 

Tyr Cys Asn Pro Gln Pro Cys Phe Ile Tyr Leu Ile Ile Ile Cys Val 
                245                 250                 255     

Leu Gly Ile Ala Ala Ile Ile Val Ser Gln Trp Asp Leu Phe Ala Thr 
            260                 265                 270         

Pro Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Val Gly Leu Gly Leu 
        275                 280                 285             

Ser Gly Ile Ile Pro Thr Leu His Phe Val Ile Ala Glu Gly Phe Leu 
    290                 295                 300                 

Lys Ala Ala Thr Met Gly Gln Ile Gly Trp Leu Val Leu Met Ala Ser 
305                 310                 315                 320 

Leu Tyr Ile Thr Gly Ala Ala Leu Tyr Ala Ala Arg Ile Pro Glu Arg 
                325                 330                 335     

Phe Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser His Gln Leu Phe 
            340                 345                 350         


His Ile Phe Val Val Ala Gly Ala Phe Val His Phe His Gly Val Ser 
        355                 360                 365             

Asn Leu Gln Glu Val Arg Phe Thr Val Gly Gly Gly Cys Ala Ala Gln 
    370                 375                 380                 


Glu Val Leu 
385         


<210>  54
<211>  358
<212>  PRT
<213>  Danio rerio

<400>  54

Met Arg Ser Cys Thr Asp His Arg Ser Asp Ser Pro Gly Gln Asn Cys 
1               5                   10                  15      

Leu His Ala Arg Arg Val Met His Glu Lys Glu Glu Thr Thr Val Arg 
            20                  25                  30          

Glu Glu Glu Asp Glu Glu Glu Glu Glu Glu Glu Glu Glu Asp Lys Ser 
        35                  40                  45              

Ser Asp Glu Gly Leu Leu Leu Gln Ala His His Ala Met Glu Arg Met 
    50                  55                  60                  

Glu Glu Phe Val His Lys Val Trp Glu Gly Arg Trp Arg Val Ile Pro 
65                  70                  75                  80  

His Asp Val Leu Pro Asp Trp Leu Lys Asp Asn Asp Phe Leu Leu His 
                85                  90                  95      

Gly His Arg Pro Pro Met Pro Ser Phe Arg Ala Cys Phe Lys Ser Ile 
            100                 105                 110         

Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His Leu Leu Gly 
        115                 120                 125             

Cys Leu Phe Phe Leu Cys Leu Gly Ile Val Tyr Met Phe Arg Pro Asn 
    130                 135                 140                 

Met Ser Phe Val Ala Pro Phe Gln Glu Lys Ile Val Ile Gly Met Phe 
145                 150                 155                 160 

Phe Leu Gly Ala Ile Leu Cys Leu Ser Phe Ser Trp Leu Phe His Thr 
                165                 170                 175     

Val Tyr Cys His Ser Glu Gly Val Ser Arg Val Phe Ser Lys Leu Asp 
            180                 185                 190         

Tyr Ser Gly Ile Ala Phe Leu Ile Met Gly Ser Phe Val Pro Trp Leu 
        195                 200                 205             

Tyr Tyr Ser Phe Tyr Cys Ser Pro Gln Pro Cys Phe Ile Tyr Leu Ile 
    210                 215                 220                 


Val Val Cys Ile Leu Gly Ile Ala Ala Ile Thr Val Ser Gln Cys Asp 
225                 230                 235                 240 

Phe Phe Ala Thr Pro Gln Tyr Arg Gly Val Arg Ala Gly Val Phe Val 
                245                 250                 255     

Gly Leu Gly Leu Ser Gly Val Val Pro Thr Leu His Phe Met Ile Ala 
            260                 265                 270         

Glu Gly Phe Leu Lys Ala Thr Thr Met Gly Gln Met Gly Trp Leu Phe 
        275                 280                 285             

Leu Met Ala Val Leu Tyr Ile Thr Gly Ala Cys Leu Tyr Ala Ala Arg 
    290                 295                 300                 

Ile Pro Glu Arg Phe Phe Pro Gly Lys Cys Asp Ile Trp Phe His Ser 
305                 310                 315                 320 

His Gln Leu Phe His Ile Leu Val Val Ala Gly Ala Phe Val His Phe 
                325                 330                 335     

His Gly Val Ser Asn Leu Gln Glu Phe Arg Tyr Glu Ala Gly Gly Gly 
            340                 345                 350         

Cys Ala Glu Asn Ala Val 
        355             


<210>  55
<211>  316
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  55

Met Ser Ile Thr Thr Thr Arg Arg Arg Asn Gln Asp Ser Val Cys Cys 
1               5                   10                  15      

Lys Ala Thr Arg Ala Ser Ile Lys Val Glu Ala Val Ser Gly Gln Thr 
            20                  25                  30          

Val Phe Glu Lys Gln Lys Leu Leu His Asn Phe Asp Glu Leu Pro Glu 
        35                  40                  45              

Trp Gln Lys Asp Asn Asp Lys Ile Leu Thr Gly Tyr Val Arg Glu Thr 
    50                  55                  60                  

Leu Ser Trp Lys Lys Cys Leu Tyr Ser Leu Phe Tyr Trp Asn Asn Glu 
65                  70                  75                  80  

Thr Val Asn Ile Tyr Thr His Leu Val Pro Ala Ile Val Tyr Phe Val 
                85                  90                  95      

Phe Ala Ile Thr Leu Thr Asn Tyr Phe Leu Ile Pro Val Phe Pro Ser 
            100                 105                 110         

Thr Ser Trp Ser Asp Tyr Thr Val Ile Asn Ile Phe Leu Met Gly Ala 
        115                 120                 125             


Phe Ser Cys Leu Met Cys Ser Ser Cys Phe His Cys Met Lys Gln His 
    130                 135                 140                 

Ser Glu Lys Gln Ser Asn Phe Trp Ser Lys Leu Asp Tyr Leu Gly Ile 
145                 150                 155                 160 

Ile Ser Leu Ile Ser Cys Ser Met Ile Pro Ile Ile Tyr Phe Gly Tyr 
                165                 170                 175     

Phe Asp His Ile Ser Tyr Phe Ser Leu Phe Thr Ile Val Thr Leu Val 
            180                 185                 190         

Leu Ala Thr Phe Cys Thr Val Cys Val Leu His Asp Lys Phe Asn Thr 
        195                 200                 205             

Ser Thr Phe Arg Pro Phe Arg Ala Met Phe Phe Ile Leu Phe Gly Phe 
    210                 215                 220                 

Ser Gly Leu Leu Pro Leu Thr Thr Gly Phe Phe Lys Phe Gly Ile Gln 
225                 230                 235                 240 

Gly Val Leu Asn Arg Ile Lys Val Ser Phe Val Phe Trp Glu Ala Leu 
                245                 250                 255     

Phe Tyr Ile Ser Gly Ala Val Ile Tyr Gly Phe Arg Ile Pro Glu Thr 
            260                 265                 270         

Leu Ala Pro Gly Lys Phe Asp Phe Phe Gly Ser Ser His Gln Ile Phe 
        275                 280                 285             

His Ile Met Val Val Leu Gly Ser Val Cys His Leu Lys Ala Ile Ile 
    290                 295                 300                 

Asp Ser Tyr Lys Leu Met His Ser His Ile His Pro 
305                 310                 315     


<210>  56
<211>  317
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  56

Met Ser Thr Leu Leu Glu Arg Thr Lys Ser Val Gln Glu Leu Lys Lys 
1               5                   10                  15      

Arg Ala Ala Gly Lys Thr Ser Ala Asn Pro Ala Glu Val Ala Lys Ala 
            20                  25                  30          

Lys Lys Val Leu Arg Arg Leu Tyr Ser Trp Asp Glu Ile Pro Glu Trp 
        35                  40                  45              

Gln Arg Asp Asn Asp Phe Ile Leu His Gly Tyr Val Lys Glu Thr Ser 
    50                  55                  60                  

Ser Phe Ile Glu Thr Phe Lys Ser Leu Phe Tyr Leu His Asn Glu Ser 
65                  70                  75                  80  


Val Asn Ile Tyr Ser His Leu Ile Pro Ala Leu Gly Phe Phe Thr Val 
                85                  90                  95      

Leu Leu Leu Asp Lys Ser Thr Ile Lys Val Phe Ala Thr Thr Thr Trp 
            100                 105                 110         

Leu Asp His Met Val Ile Asp Leu Phe Tyr Ser Gly Ala Phe Ala Cys 
        115                 120                 125             

Leu Ile Leu Ser Ser Ser Phe His Cys Leu Lys Ser His Ser Leu Arg 
    130                 135                 140                 

Ile Ala Thr Leu Gly Asn Lys Leu Asp Tyr Leu Gly Ile Cys Ile Leu 
145                 150                 155                 160 

Ile Val Thr Ser Met Val Ser Ile Leu Tyr Tyr Gly Tyr Phe Glu Lys 
                165                 170                 175     

Phe Ser Leu Phe Cys Leu Phe Ala Leu Ile Thr Val Ser Phe Gly Ile 
            180                 185                 190         

Ala Cys Ser Ile Val Ser Leu Lys Asp Lys Phe Arg Lys Arg Glu Trp 
        195                 200                 205             

Arg Pro Tyr Arg Ala Gly Leu Phe Val Cys Phe Gly Leu Ser Ser Ile 
    210                 215                 220                 

Ile Pro Ile Phe Ser Gly Leu Tyr Cys Tyr Ser Phe Ser Glu Ile Trp 
225                 230                 235                 240 

Thr Gln Ile Gln Leu Phe Trp Val Leu Leu Gly Gly Val Leu Tyr Ile 
                245                 250                 255     

Ile Gly Ala Val Leu Tyr Gly Met Arg Phe Pro Glu Lys Ile Cys Pro 
            260                 265                 270         

Gly Lys Phe Asp Ile Trp Gly His Ser His Gln Leu Phe His Phe Leu 
        275                 280                 285             

Val Val Ile Ala Ala Leu Cys His Leu Arg Gly Leu Leu Asn Ser Tyr 
    290                 295                 300                 

Glu Leu Val His Ile Lys Met Glu Asn Gly Ile Val Ser 
305                 310                 315         


<210>  57
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  57

Met Leu Ser Leu Lys Leu Pro Arg Leu Phe Ser Ile Asp Gln Ile Pro 
1               5                   10                  15      

Gln Val Phe His Glu Gln Gly Ile Leu Phe Gly Tyr Arg His Pro Gln 
            20                  25                  30          


Ser Ser Ala Thr Ala Cys Ile Leu Ser Leu Phe Gln Met Thr Asn Glu 
        35                  40                  45              

Thr Leu Asn Ile Trp Thr His Leu Leu Pro Phe Trp Phe Phe Ala Trp 
    50                  55                  60                  

Arg Phe Val Thr Ala Leu Tyr Met Thr Asp Ile Lys Asn Asp Ser Tyr 
65                  70                  75                  80  

Ser Trp Pro Met Leu Val Tyr Met Cys Thr Ser Cys Val Tyr Pro Leu 
                85                  90                  95      

Val Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg 
            100                 105                 110         

His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu 
        115                 120                 125             

Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Ala Leu Met 
    130                 135                 140                 

Cys Thr Thr Phe His Asp Tyr Tyr Val Ala Leu Ala Val Leu Asn Thr 
145                 150                 155                 160 

Ile Leu Ser Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Val Gln 
                165                 170                 175     

Lys Pro Arg Leu Cys Lys Val Ile Arg Val Leu Ala Phe Ala Tyr Pro 
            180                 185                 190         

Tyr Thr Trp Asp Ser Leu Pro Ile Phe Tyr Arg Leu Phe Leu Phe Pro 
        195                 200                 205             


Gly Glu Ser Ala Gln Asn Glu Ala Thr Ser Tyr His Gln Lys His Met 
    210                 215                 220                 

Ile Met Thr Leu Leu Ala Ser Phe Leu Tyr Ser Ala His Leu Pro Glu 
225                 230                 235                 240 

Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu 
                245                 250                 255     


Phe His Val Cys Val Ile Leu Ala Thr His Met Gln Met Glu Ala Ile 
            260                 265                 270         

Leu Leu Asp Lys Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Lys 
        275                 280                 285             

Pro Phe Ser Phe Ser Gln Ile Ala Gly Ala Ile Leu Leu Cys Ile Ile 
    290                 295                 300                 

Phe Ser Leu Ser Asn Ile Ile Tyr Phe Ser Ala Ala Leu Tyr Arg Ile 
305                 310                 315                 320 

Pro Lys Pro Glu Leu His Lys Lys Glu Thr 
                325                 330 


<210>  58
<211>  330
<212>  PRT
<213>  Monodelphis domestica

<400>  58

Met Leu Ser Leu Lys Leu Pro Lys Leu Phe Asn Ile Asp Gln Val Pro 
1               5                   10                  15      

Gln Val Phe His Glu Arg Gly Ile Ile Cys Gly Tyr Arg His Pro Gln 
            20                  25                  30          

Ser Ser Ala Ile Ala Cys Val Leu Ser Leu Phe Gln Met Thr Asn Glu 
        35                  40                  45              

Thr Leu Asn Ile Trp Thr His Leu Leu Pro Ser Trp Tyr Phe Met Trp 
    50                  55                  60                  

Arg Phe Met Ala Thr Leu Tyr Met Val Asp Phe Trp Asn Asp Ser Tyr 
65                  70                  75                  80  

Ser Trp Pro Leu Leu Ile Tyr Leu Ser Thr Ser Phe Ile Tyr Pro Phe 
                85                  90                  95      

Ala Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Lys Asn Ala Arg 
            100                 105                 110         

His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Val Asn Leu Phe Ser Leu 
        115                 120                 125             

Gly Ser Ala Ile Ala Tyr Ser Ala Tyr Thr Phe Pro Asp Met Leu Val 
    130                 135                 140                 

Arg Thr Thr Phe His His Tyr Phe Val Ser Leu Ala Val Leu Asn Thr 
145                 150                 155                 160 

Ile Leu Ser Ile Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Leu Gln 
                165                 170                 175     

Lys Pro Lys Leu Cys Lys Thr Leu Arg Ile Leu Ala Phe Ala Tyr Pro 
            180                 185                 190         

Tyr Ala Trp Asp Thr Val Pro Ile Ile Tyr Arg Leu Phe Leu Ser Ser 
        195                 200                 205             

Glu Glu Ser Ser Gly Glu Ala Ala Asn Pro Tyr His Gln Lys His Thr 
    210                 215                 220                 

Val Ile Ala Ile Leu Ala Cys Phe Leu Tyr Ala Ala His Leu Pro Glu 
225                 230                 235                 240 

Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln Leu 
                245                 250                 255     

Phe His Val Cys Val Ile Leu Ala Thr His Leu Gln Met Glu Ala Ile 
            260                 265                 270         


Phe Leu Asp Met Thr Leu Arg Lys Glu Trp Leu Leu Ala Thr Ser Ile 
        275                 280                 285             

Pro Pro Ser Phe Ser Gln Thr Ala Gly Ala Val Cys Leu Cys Ile Ile 
    290                 295                 300                 

Phe Ser Ile Ile Asn Ile Ile Tyr Phe Ser Ile Ser Leu Tyr Gln Thr 
305                 310                 315                 320 

Pro Glu Pro Glu Ser Gln Lys Lys Glu Thr 
                325                 330 


<210>  59
<211>  327
<212>  PRT
<213>  Gallus gallus

<400>  59

Met Leu Ser Leu Lys Leu Pro Arg Leu Leu Ser Ile His Gln Val Pro 
1               5                   10                  15      

Lys Val Tyr Gln Glu Gln Gly Ile Leu Cys Gly Tyr Arg Pro Pro Arg 
            20                  25                  30          

Ile Ser Ala Ala Asp Cys Val Leu Ser Ala Phe Gln Met Thr Asn Glu 
        35                  40                  45              

Thr Leu Asn Ile Trp Thr His Phe Leu Pro Ala Trp Tyr Phe Val Trp 
    50                  55                  60                  

Met Leu Val Gly Arg Leu Trp Gly Pro Gly Gly Arg Asp Pro Pro Ala 
65                  70                  75                  80  

Trp Pro Leu Leu Ala Tyr Leu Leu Ser Cys Cys Ile Tyr Pro Leu Ala 
                85                  90                  95      

Ser Ser Cys Ala His Thr Phe Ser Pro Met Ser Ala Arg Ala Arg His 
            100                 105                 110         

Val Cys Tyr Phe Phe Asp Tyr Ala Ala Leu Ser Met Tyr Ser Leu Gly 
        115                 120                 125             

Ser Ala Leu Ala Tyr Ser Ala Tyr Val Phe Pro Glu Glu Trp Val Gly 
    130                 135                 140                 

Ser Ile Phe His Cys Cys Tyr Val Pro Val Ala Val Leu Asn Thr Val 
145                 150                 155                 160 

Leu Ser Thr Ser Leu Ala Cys Tyr Ser Arg Phe Leu Glu Leu Glu Arg 
                165                 170                 175     

Pro Trp Leu Ser Lys Ala Ser Arg Thr Leu Ala Phe Val Tyr Pro Tyr 
            180                 185                 190         

Leu Phe Asp Ser Ile Pro Leu Phe Tyr Arg Val Tyr Val Cys Ala Ala 
        195                 200                 205             


Arg Ser Cys Ala Asp Pro Thr Val Ala Ala His Tyr Arg His Thr Ala 
    210                 215                 220                 

Phe Ala Phe Leu Thr Cys Phe Ile Phe Ala Thr His Leu Pro Glu Arg 
225                 230                 235                 240 

Leu Ala Pro Gly His Phe Asp Tyr Ile Gly His Ser His Gln Val Phe 
                245                 250                 255     

His Val Cys Gly Ile Leu Gly Thr His Phe Gln Leu Glu Ala Ile Leu 
            260                 265                 270         

Met Asp Met Ser Glu Arg Gln Ala Arg Leu Pro Ala Thr Ser Leu Leu 
        275                 280                 285             

Gln Ala Leu Ala Pro Met Gly Thr Cys Met Ala Val Gly Leu Ala Val 
    290                 295                 300                 

Ile Ala His Cys Ser Ala Gln Leu Cys Arg Ala Pro Glu Pro Ser His 
305                 310                 315                 320 

Arg Glu Lys Leu His Gly Gln 
                325         


<210>  60
<211>  330
<212>  PRT
<213>  Xenopus tropicalis

<400>  60

Met Leu Ser Trp Lys Leu Pro Arg Leu Leu Thr Ile Gln Gln Val Pro 
1               5                   10                  15      

Lys Val Phe His Glu Asp Ser Ile Ile Cys Gly Tyr Arg Ser Pro Cys 
            20                  25                  30          

Ser Ser Ala Thr Ala Cys Val Leu Ser Leu Phe Gln Met Thr Asn Glu 
        35                  40                  45              

Thr Val Asn Ile Trp Thr His Phe Ile Pro Thr Trp Tyr Phe Leu Trp 
    50                  55                  60                  

Lys Met Leu Ser Phe Leu Tyr Ser Gly Phe Trp Asp Asp Pro Phe Leu 
65                  70                  75                  80  

Trp Pro Leu Leu Val Tyr Gln Leu Ser Cys Cys Ile Tyr Pro Leu Met 
                85                  90                  95      

Ser Thr Cys Ala His Thr Phe Ser Val Met Ser Thr Lys Ala Arg His 
            100                 105                 110         

Ile Cys Phe Phe Leu Asp Tyr Gly Ala Val Ser Leu Tyr Ser Leu Gly 
        115                 120                 125             

Ala Ala Ile Ala Tyr Ser Ala Tyr Val Phe Pro Asp Arg Trp Val Gly 
    130                 135                 140                 


Gly Thr Phe His Arg Trp Tyr Val Phe Cys Ala Val Met Asn Thr Gly 
145                 150                 155                 160 

Ile Cys Thr Ala Leu Ala Cys Tyr Ser Arg Ile Pro Glu Val Ala Arg 
                165                 170                 175     

Pro Arg Leu Ser Lys Val Leu Arg Thr Thr Ala Phe Ala Tyr Pro Tyr 
            180                 185                 190         

Leu Phe Asp Ser Ile Pro Leu Phe Tyr Arg Leu Phe Leu Cys Ser Gly 
        195                 200                 205             

Ser Gly Cys Ala Gln Asn Ala Ala Leu Pro Met His Ile Trp His Ser 
    210                 215                 220                 

Ile Leu Ala Phe Leu Thr Ala Phe Leu Phe Ala Thr His Leu Pro Glu 
225                 230                 235                 240 

Arg Leu Ala Pro Gly Cys Phe Asp Tyr Val Gly His Ser His Gln Leu 
                245                 250                 255     

Phe His Val Cys Gly Ile Leu Gly Thr Tyr Ile Gln Met Glu Val Leu 
            260                 265                 270         

Ile Lys Asp Met Asn Leu Arg Lys Lys Trp Leu Met Asp Lys Asp Asn 
        275                 280                 285             

Ile Pro Ser Phe Ser Asn Thr Leu Gly Ala Trp Gly Leu Gly Met Ile 
    290                 295                 300                 

Met Ser Phe Ile Val Ile Ala Cys Phe Ser Leu Ala Leu Tyr Trp Lys 
305                 310                 315                 320 

Pro Gln Thr Gln Lys Asn Lys Arg Lys Met 
                325                 330 


<210>  61
<211>  332
<212>  PRT
<213>  Danio rerio

<400>  61

Met Leu Ser Leu Ile Lys Leu Gln Arg Val Phe Asn Val His Gln Val 
1               5                   10                  15      

Pro Lys Ala Phe His Glu Asp Gly Ile Ile Ser Gly Tyr Arg His Pro 
            20                  25                  30          

Arg Ser Ser Ala Thr Glu Cys Val Trp Ser Leu Phe Gln Leu Thr Asn 
        35                  40                  45              

Glu Thr Leu Asn Val Trp Thr His Phe Leu Pro Thr Trp Tyr Phe Leu 
    50                  55                  60                  

Trp Lys Leu Met Thr Val Leu Leu Met Glu Asp Val Trp Asn Glu Ala 
65                  70                  75                  80  

Tyr Thr Trp Pro Leu Leu Val Phe Leu Phe Ser Cys Cys Val Tyr Pro 
                85                  90                  95      

Leu Ala Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Thr Arg Ala 
            100                 105                 110         

Arg His Ile Cys Tyr Phe Phe Asp Tyr Gly Ala Leu Ser Phe Tyr Ser 
        115                 120                 125             

Leu Gly Ser Ala Ile Ser Tyr Ser Ala Tyr Val Phe Pro Asp Ala Trp 
    130                 135                 140                 

Leu Ser Ser Ser Phe His Ala Tyr Tyr Ile Ser Val Ala Val Phe Asn 
145                 150                 155                 160 

Thr Val Leu Ser Thr Ser Leu Ala Cys Tyr Ser Arg Phe Ser Glu Arg 
                165                 170                 175     

Gln Cys Pro Arg Met Ser Lys Val Leu Arg Ile Leu Ala Phe Ala Tyr 
            180                 185                 190         

Pro Tyr Leu Phe Asp Asn Ile Pro Leu Phe Tyr Arg Leu Phe Val Cys 
        195                 200                 205             

Val Gly Glu Gly Cys Thr Asp Asn Glu Ala Asn Ser Val His Val Gln 
    210                 215                 220                 

His Thr Leu Leu Ala Phe Leu Thr Ser Phe Leu Phe Ala Thr His Leu 
225                 230                 235                 240 

Pro Glu Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His 
                245                 250                 255     

Gln Leu Phe His Val Cys Ala Ile Ile Gly Thr His Phe Gln Met Lys 
            260                 265                 270         

Ala Ile Glu Met Asp Met Gly Leu Arg Arg Ser Gln Leu Leu Ala Ser 
        275                 280                 285             

Ala Pro Ala Ile Ser Phe Asn Asn Thr Ile Gly Ala Ala Leu Leu Cys 
    290                 295                 300                 

Val Ser Val Ser Leu Gly Ile Ile Cys Val Tyr Ser Leu Pro Leu Leu 
305                 310                 315                 320 

Tyr Ser Ser Asn Pro Lys Asn Thr Ala Asn Lys Glu 
                325                 330         


<210>  62
<211>  332
<212>  PRT
<213>  Danio rerio

<400>  62

Met Leu Ser Leu Ile Lys Leu Gln Arg Val Phe Asn Val His Gln Val 
1               5                   10                  15      


Pro Lys Ala Phe His Glu Asp Gly Ile Ile Ser Gly Tyr Arg His Pro 
            20                  25                  30          

Arg Ser Ser Ala Thr Glu Cys Val Trp Ser Leu Phe Gln Leu Thr Asn 
        35                  40                  45              

Glu Thr Leu Asn Val Trp Thr His Phe Leu Pro Thr Trp Tyr Phe Leu 
    50                  55                  60                  

Trp Lys Leu Met Thr Val Leu Leu Met Glu Asp Val Trp Asn Glu Ala 
65                  70                  75                  80  

Tyr Thr Trp Pro Leu Leu Val Phe Leu Phe Ser Cys Cys Val Tyr Pro 
                85                  90                  95      

Leu Ala Ser Ser Cys Ala His Thr Phe Ser Ser Met Ser Thr Arg Ala 
            100                 105                 110         

Arg His Ile Cys Tyr Phe Phe Asp Tyr Gly Ala Leu Ser Phe Tyr Ser 
        115                 120                 125             

Leu Gly Ser Ala Ile Ser Tyr Ser Ala Tyr Val Phe Pro Asp Ala Trp 
    130                 135                 140                 

Leu Ser Ser Ser Phe His Ala Tyr Tyr Ile Ser Val Ala Val Phe Asn 
145                 150                 155                 160 

Thr Val Leu Ser Thr Ser Leu Ala Cys Tyr Ser Arg Phe Ser Glu Arg 
                165                 170                 175     

Gln Cys Pro Arg Met Ser Lys Val Leu Arg Ile Leu Ala Phe Ala Tyr 
            180                 185                 190         

Pro Tyr Leu Phe Asp Asn Ile Pro Leu Phe Tyr Arg Leu Phe Val Cys 
        195                 200                 205             

Val Gly Glu Gly Cys Thr Asp Asn Glu Ala Asn Ser Val His Val Gln 
    210                 215                 220                 

His Thr Leu Leu Ala Phe Leu Thr Ser Phe Leu Phe Ala Thr His Leu 
225                 230                 235                 240 

Pro Glu Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His 
                245                 250                 255     

Gln Leu Phe His Val Cys Ala Ile Ile Gly Thr His Phe Gln Met Lys 
            260                 265                 270         

Ala Ile Glu Met Asp Met Gly Leu Arg Arg Ser Gln Leu Leu Ala Ser 
        275                 280                 285             

Ala Pro Ala Ile Ser Phe Asn Asn Thr Ile Gly Ala Ala Leu Leu Cys 
    290                 295                 300                 

Val Ser Val Ser Leu Gly Ile Ile Cys Val Tyr Ser Leu Pro Leu Leu 
305                 310                 315                 320 

Tyr Ser Ser Asn Pro Lys Asn Thr Ala Asn Lys Glu 
                325                 330         


<210>  63
<211>  326
<212>  PRT
<213>  Danio rerio

<400>  63

Met Leu Asn Leu Ile Lys Leu Pro Gln Val Phe Thr Ile Asn Gln Val 
1               5                   10                  15      

Pro Lys Val Phe His Glu Asp Gly Ile Ile Ser Gly Tyr Arg His Pro 
            20                  25                  30          

Cys Ser Ser Ala Lys Asp Cys Val Leu Ser Leu Phe Gln Leu Thr Asn 
        35                  40                  45              

Glu Thr Leu Asn Ile Trp Thr His Phe Leu Pro Thr Trp Phe Phe Leu 
    50                  55                  60                  

Trp Lys Leu Leu Thr Val Val Leu Val Leu Glu Asp Trp Arg Asp Pro 
65                  70                  75                  80  

Phe Ile Trp Pro Phe Leu Val Phe Leu Leu Ser Cys Cys Val Tyr Pro 
                85                  90                  95      

Leu Ala Ser Ser Cys Ala His Thr Phe Ser Thr Met Ser Glu Arg Ala 
            100                 105                 110         

Arg His Ile Cys Phe Phe Phe Asp Tyr Gly Ala Leu Ser Phe Tyr Ser 
        115                 120                 125             

Leu Gly Ser Ala Ile Ile Tyr Ser Ser Tyr Ser Phe Pro Asp Lys Trp 
    130                 135                 140                 

Val Asn Gly Thr Phe His Leu Asn Tyr Val Ser Ile Ala Val Val Asn 
145                 150                 155                 160 

Ser Ile Ile Ser Thr Ala Leu Ala Cys Tyr Ser Arg Leu Gly Gln Lys 
                165                 170                 175     

Leu Cys Lys Cys Leu Arg Ile Ile Ala Phe Val Tyr Pro Tyr Leu Phe 
            180                 185                 190         

Asp Asn Ile Pro Leu Phe Tyr Arg Ile Phe Val Cys Ala Gly Glu Gly 
        195                 200                 205             

Cys Thr Val Asn Glu Ala Asn Thr Val His Tyr Gln His Thr Ser Leu 
    210                 215                 220                 


Ala Phe Phe Thr Gly Phe Leu Phe Ala Thr His Leu Pro Glu Arg Leu 
225                 230                 235                 240 

Ala Pro Gly Ser Phe Asp Tyr Ile Gly His Ser His Gln Leu Phe His 
                245                 250                 255     

Val Phe Ala Ile Ile Gly Thr Tyr Phe Gln Met Thr Ala Ile Glu Leu 
            260                 265                 270         

Asp Met Ala Ala Arg Lys Gln Trp Leu His Ala His Leu Pro Pro Val 
        275                 280                 285             

Thr Phe Leu Asn Thr Val Gly Ala Ala Phe Phe Ser Val Val Ser Gly 
    290                 295                 300                 

Leu Cys Ile Val Tyr Val Phe Ser Leu Ser Leu Phe Ser Thr Arg Gly 
305                 310                 315                 320 

Val Lys Asn Lys Ser Phe 
                325     


<210>  64
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Leu Ser Leu Lys Leu Pro Gln Leu Leu Gln Val His Gln Val Pro 
1               5                   10                  15      

Arg Val Phe Trp Glu Asp Gly Ile Met Ser Gly Tyr Arg Arg Pro Thr 
            20                  25                  30          

Ser Ser Ala Leu Asp Cys Val Leu Ser Ser Phe Gln Met Thr Asn Glu 
        35                  40                  45              

Thr Val Asn Ile Trp Thr His Phe Leu Pro Thr Trp Tyr Phe Leu Trp 
    50                  55                  60                  

Arg Leu Leu Ala Leu Ala Gly Gly Pro Gly Phe Arg Ala Glu Pro Tyr 
65                  70                  75                  80  

His Trp Pro Leu Leu Val Phe Leu Leu Pro Ala Cys Leu Tyr Pro Phe 
                85                  90                  95      

Ala Ser Cys Cys Ala His Thr Phe Ser Ser Met Ser Pro Arg Met Arg 
            100                 105                 110         

His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Leu Ser Leu Tyr Ser Leu 
        115                 120                 125             

Gly Cys Ala Phe Pro Tyr Ala Ala Tyr Ser Met Pro Ala Ser Trp Leu 
    130                 135                 140                 

His Gly His Leu His Gln Phe Phe Val Pro Ala Ala Ala Leu Asn Ser 
145                 150                 155                 160 

Phe Leu Cys Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Leu Glu 
                165                 170                 175     

Ser Pro Gly Leu Ser Lys Val Leu Arg Thr Gly Ala Phe Ala Tyr Pro 
            180                 185                 190         

Phe Leu Phe Asp Asn Leu Pro Leu Phe Tyr Arg Leu Gly Leu Cys Trp 
        195                 200                 205             


Gly Arg Gly His Gly Cys Gly Gln Glu Ala Leu Ser Thr Ser His Gly 
    210                 215                 220                 

Tyr His Leu Phe Cys Ala Leu Leu Thr Gly Phe Leu Phe Ala Ser His 
225                 230                 235                 240 

Leu Pro Glu Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser 
                245                 250                 255     

His Gln Leu Phe His Ile Cys Ala Val Leu Gly Thr His Phe Gln Leu 
            260                 265                 270         

Glu Ala Val Leu Ala Asp Met Gly Ser Arg Arg Ala Trp Leu Ala Thr 
        275                 280                 285             

Gln Glu Pro Ala Leu Gly Leu Ala Gly Thr Val Ala Thr Leu Val Leu 
    290                 295                 300                 

Ala Ala Ala Gly Asn Leu Leu Ile Ile Ala Ala Phe Thr Ala Thr Leu 
305                 310                 315                 320 

Leu Arg Ala Pro Ser Thr Cys Pro Leu Leu Gln Gly Gly Pro Leu Glu 
                325                 330                 335     

Gly Gly Thr Gln Ala Lys Gln Gln 
            340                 


<210>  65
<211>  343
<212>  PRT
<213>  Monodelphis domestica

<400>  65

Met Leu Ser Ile Lys Leu Pro Gln Leu Leu Arg Val His Gln Val Pro 
1               5                   10                  15      

Arg Val Phe Trp Glu Asp Gly Ile Ile Ser Gly Tyr Arg His Pro Thr 
            20                  25                  30          

Ser Ser Ala Leu Asp Cys Val Leu Ser Ser Phe Gln Met Thr Asn Glu 
        35                  40                  45              

Thr Val Asn Ile Trp Thr His Phe Leu Pro Thr Trp Tyr Phe Leu Trp 
    50                  55                  60                  

Arg Phe Leu Ala Leu Ala Glu Gly Pro Gly Phe Trp Asp Pro Tyr His 
65                  70                  75                  80  

Trp Pro Leu Leu Val Phe Leu Leu Leu Ile Cys Leu Tyr Pro Phe Thr 
                85                  90                  95      

Ser Cys Cys Ala His Thr Phe Ser Ser Met Ser Pro Arg Ala Arg His 
            100                 105                 110         

Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Leu Ser Leu Tyr Ser Leu Gly 
        115                 120                 125             


Cys Ala Leu Thr Tyr Gly Ala Tyr Ala Met Pro Ser Ser Trp Leu Asn 
    130                 135                 140                 


Ser Asn Leu His Gln Leu Phe Val Pro Ala Ala Ala Val Asn Ser Leu 
145                 150                 155                 160 


Leu Cys Thr Phe Leu Ser Cys Tyr Ser Arg Phe Leu Glu Leu Glu Asn 
                165                 170                 175     


Pro Arg Leu Ser Lys Val Leu Arg Thr Val Ala Phe Ala Tyr Pro Phe 
            180                 185                 190         


Phe Phe Asp Asn Leu Pro Leu Phe Tyr Arg Leu Leu Leu Cys Ser Arg 
        195                 200                 205             


Gly Ser Phe Ser Cys Gly Gln Glu Ala Leu Ser Val Asn His Ser Tyr 
    210                 215                 220                 


His Leu Leu Cys Ala Leu Leu Thr Gly Phe Leu Phe Ala Ser His Phe 
225                 230                 235                 240 


Pro Glu Cys Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His 
                245                 250                 255     


Gln Leu Phe His Ile Cys Ala Val Leu Gly Thr His Phe Gln Leu Glu 
            260                 265                 270         


Ala Val Leu Ala Asp Met Gly Ser Arg Arg Ala Trp Leu Ala Thr Gln 
        275                 280                 285             


Glu Pro Ala Leu Gly Leu Ala Gly Thr Val Ala Thr Leu Val Leu Ala 
    290                 295                 300                 


Ala Ala Gly Asn Leu Leu Ile Ile Ala Ala Phe Thr Ala Thr Leu Leu 
305                 310                 315                 320 


Arg Ala Pro Ser Thr Cys Pro Leu Leu Gln Gly Gly Pro Leu Glu Gly 
                325                 330                 335     


Gly Thr Gln Ala Lys Gln Gln 
            340             


<210>  66
<211>  340
<212>  PRT
<213>  Xenopus tropicalis

<400>  66

Met Leu Thr Ile Lys Leu Pro Gln Leu Phe Arg Val His Gln Met Pro 
1               5                   10                  15      


Arg Val Phe Trp Glu Asp Gly Ile Ile Ser Gly Tyr Arg His Pro Lys 
            20                  25                  30          


Ser Ser Ala Leu Asp Cys Leu Leu Ser Ser Phe Gln Met Thr Asn Glu 
        35                  40                  45              


Thr Val Asn Ile Trp Thr His Phe Leu Pro Thr Trp Tyr Phe Leu Trp 
    50                  55                  60                  


Arg Phe Leu Leu Leu Ser His Thr Leu Asp Phe Trp Gly His Ser Tyr 
65                  70                  75                  80  


Asn Trp Pro Leu Leu Val Tyr Met Met Leu Ile Cys Leu Tyr Pro Phe 
                85                  90                  95      


Thr Ser Ser Phe Ala His Thr Phe Ser Ser Met Ser Ala His Ala Arg 
            100                 105                 110         


His Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Leu Ser Leu Tyr Ser Leu 
        115                 120                 125             


Gly Ser Ala Phe Ile Tyr Ser Ala Tyr Ile Met Pro Asp Arg Trp Ile 
    130                 135                 140                 


Asn Ser Ala Leu His Arg Tyr Phe Val Pro Ile Ala Ala Phe Asn Thr 
145                 150                 155                 160 


Phe Ile Cys Thr Gly Leu Ser Cys Tyr Ser Arg Phe Leu Glu Val Asp 
                165                 170                 175     


Gln Pro Gln Leu Ser Lys Val Leu Arg Thr Val Ala Phe Val His Pro 
            180                 185                 190         


Phe Met Phe Asp Asn Ile Pro Leu Phe Phe Arg Leu Ile Phe Cys Phe 
        195                 200                 205             


Gly Glu Asp Cys Asn Trp Asn Glu Ala Val Arg Leu His Phe Thr His 
    210                 215                 220                 


Leu Ser Phe Ala Phe Leu Thr Gly Phe Leu Phe Ala Ser His Leu Pro 
225                 230                 235                 240 


Glu Arg Leu Ala Pro Gly Arg Phe Asp Tyr Phe Gly His Ser His Gln 
                245                 250                 255     


Leu Phe His Ile Cys Ala Val Leu Gly Thr His Phe Gln Leu Glu Ala 
            260                 265                 270         


Val Leu Cys Asp Arg Ala Ala Arg Glu Ala Trp Leu Ala Ala His Ser 
        275                 280                 285             


Asp Gly Asp Ser Leu Ala Val Thr Leu Gly Val Val Ala Thr Ala Leu 
    290                 295                 300                 


Ile Gly Asn Leu Ile Leu Ile Cys Phe Phe Thr Ala Thr Leu Leu Trp 
305                 310                 315                 320 


Ser Pro Arg Ala Asn Ser Ile Leu Gln Asn His Ser Pro Gly Asp Ala 
                325                 330                 335     


Arg Phe Lys Glu 
            340 


<210>  67
<211>  332
<212>  PRT
<213>  Danio rerio

<400>  67

Met Leu Ser Leu Arg Leu Pro Gln Leu Phe Asp Ile His Gln Val Pro 
1               5                   10                  15      


Lys Val Phe Arg Glu Asp Gly Ile Met Ser Gly Tyr Arg His Pro Arg 
            20                  25                  30          


Ser Ser Ala Leu Asp Cys Ile Leu Ser Ser Phe Gln Met Thr Asn Glu 
        35                  40                  45              


Thr Val Asn Ile Trp Thr His Phe Leu Pro Thr Trp Tyr Phe Leu Trp 
    50                  55                  60                  


Arg Phe Ser Val Leu Cys Ser Ser Leu Asp Phe Val Thr Asp Ser Tyr 
65                  70                  75                  80  


Thr Trp Pro Leu Leu Val Tyr Met Leu Leu Ile Cys Leu Tyr Pro Phe 
                85                  90                  95      


Thr Ser Ser Cys Ala His Thr Phe Ser Thr Met Ser Ala Glu Ala Arg 
            100                 105                 110         


His Ile Cys Tyr Phe Phe Asp Tyr Gly Ala Leu Ser Leu Tyr Ser Leu 
        115                 120                 125             


Gly Cys Ala Ile Ser Tyr Gly Ser Tyr Ala Met Pro Asp Ser Trp Val 
    130                 135                 140                 


Asn Ser Trp Leu His Gln His Phe Val Thr Ile Gly Ile Cys Asn Ser 
145                 150                 155                 160 


Leu Phe Cys Thr Ser Met Ser Cys Tyr Thr Arg Phe Ile Glu Leu Gln 
                165                 170                 175     


Phe Pro His Lys Ser Lys Ile Leu Arg Thr Ser Ala Phe Val Val Pro 
            180                 185                 190         


Phe Leu Phe Asp Ser Phe Pro Leu Phe Tyr Arg Leu Leu Ser Cys Cys 
        195                 200                 205             


Trp Gly Ser Cys Ser Pro Ser Glu Ala Leu Ala Ser His Ser Tyr His 
    210                 215                 220                 


Leu Leu Phe Ala Phe Leu Thr Cys Phe Leu Phe Ala Ser His Leu Pro 
225                 230                 235                 240 


Glu Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His Gln 
                245                 250                 255     


Leu Phe His Ile Cys Ala Val Val Gly Thr His Phe Gln Met Glu Ala 
            260                 265                 270         


Ala Leu Ser Asp Met Ala Ser Arg Lys Asp Trp Leu Ile Ser Tyr Ser 
        275                 280                 285             


Gly Leu Pro Thr Phe Gln Gly Thr Met Gly Ala Leu Ala Leu Gly Val 
    290                 295                 300                 


Leu Leu Asn Leu Ala Ile Ile Gly Val Phe Ser Ala Ser Leu Ile Gln 
305                 310                 315                 320 


Thr Pro Arg Gln Ser Thr Ser His Pro His Gln Glu 
                325                 330         


<210>  68
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Met Ala Gln Lys Leu Ser His Leu Leu Pro Ser Leu Arg Gln 
1               5                   10                  15      


Val Ile Gln Glu Pro Gln Leu Ser Leu Gln Pro Glu Pro Val Phe Thr 
            20                  25                  30          


Val Asp Arg Ala Glu Val Pro Pro Leu Phe Trp Lys Pro Tyr Ile Tyr 
        35                  40                  45              


Ala Gly Tyr Arg Pro Leu His Gln Thr Trp Arg Phe Tyr Phe Arg Thr 
    50                  55                  60                  


Leu Phe Gln Gln His Asn Glu Ala Val Asn Val Trp Thr His Leu Leu 
65                  70                  75                  80  


Ala Ala Leu Val Leu Leu Leu Arg Leu Ala Leu Phe Val Glu Thr Val 
                85                  90                  95      


Asp Phe Trp Gly Asp Pro His Ala Leu Pro Leu Phe Ile Ile Val Leu 
            100                 105                 110         


Ala Ser Phe Thr Tyr Leu Ser Phe Ser Ala Leu Ala His Leu Leu Gln 
        115                 120                 125             


Ala Lys Ser Glu Phe Trp His Tyr Ser Phe Phe Phe Leu Asp Tyr Val 
    130                 135                 140                 


Gly Val Ala Val Tyr Gln Phe Gly Ser Ala Leu Ala His Phe Tyr Tyr 
145                 150                 155                 160 


Ala Ile Glu Pro Ala Trp His Ala Gln Val Gln Ala Val Phe Leu Pro 
                165                 170                 175     


Met Ala Ala Phe Leu Ala Trp Leu Ser Cys Ile Gly Ser Cys Tyr Asn 
            180                 185                 190         


Lys Tyr Ile Gln Lys Pro Gly Leu Leu Gly Arg Thr Cys Gln Glu Val 
        195                 200                 205             


Pro Ser Val Leu Ala Tyr Ala Leu Asp Ile Ser Pro Val Val His Arg 
    210                 215                 220                 


Ile Phe Val Ser Ser Asp Pro Thr Thr Asp Asp Pro Ala Leu Leu Tyr 
225                 230                 235                 240 


His Lys Cys Gln Val Val Phe Phe Leu Leu Ala Ala Ala Phe Phe Ser 
                245                 250                 255     


Thr Phe Met Pro Glu Arg Trp Phe Pro Gly Ser Cys His Val Phe Gly 
            260                 265                 270         


Gln Gly His Gln Leu Phe His Ile Phe Leu Val Leu Cys Thr Leu Ala 
        275                 280                 285             


Gln Leu Glu Ala Val Ala Leu Asp Tyr Glu Ala Arg Arg Pro Ile Tyr 
    290                 295                 300                 


Glu Pro Leu His Thr His Trp Pro His Asn Phe Ser Gly Leu Phe Leu 
305                 310                 315                 320 


Leu Thr Val Gly Ser Ser Ile Leu Thr Ala Phe Leu Leu Ser Gln Leu 
                325                 330                 335     


Val Gln Arg Lys Leu Asp Gln Lys Thr Lys 
            340                 345     


<210>  69
<211>  351
<212>  PRT
<213>  Monodelphis domestica

<400>  69

Met Ala Thr Ala Ile Ala Gln Lys Leu Ser Arg Phe Phe Pro Ser Val 
1               5                   10                  15      


Arg Gln Leu Gly Gln Met Pro Arg Ile Leu Gly Glu Leu Ala Ala Pro 
            20                  25                  30          


Leu Pro Asp Ser Thr Val Gly Arg Ala Glu Val Pro Arg Leu Phe Trp 
        35                  40                  45              


Lys Pro Tyr Ile Tyr Ser Gly Tyr Arg Pro Leu His Arg Thr Trp Arg 
    50                  55                  60                  


Phe Tyr Phe Leu Ser Leu Phe Gln Lys His Asn Glu Ala Val Asn Val 
65                  70                  75                  80  


Trp Thr His Leu Val Ala Ala Met Val Leu Leu Leu Arg Leu Ala Tyr 
                85                  90                  95      


Phe Ala Gly Ser Val Asp Phe Val Gly Asp Pro His Ala Arg Pro Leu 
            100                 105                 110         


Phe Leu Ile Val Leu Ala Ser Ile Thr Tyr Leu Phe Phe Ser Ala Val 
        115                 120                 125             


Ala His Leu Leu Gln Ala Lys Ser Glu Phe Trp His Tyr Ser Phe Phe 
    130                 135                 140                 


Phe Leu Asp Tyr Val Gly Val Ala Val Tyr Gln Phe Gly Ser Ala Leu 
145                 150                 155                 160 


Ala His Phe Tyr Tyr Ala Ile Glu Pro Ala Trp His Ala Arg Met Ala 
                165                 170                 175     


Ala Phe Phe Leu Pro Ala Ala Ala Phe Leu Ala Trp Leu Ser Cys Ala 
            180                 185                 190         


Gly Ser Cys Tyr Thr Lys Tyr Arg Gln Leu Pro Gly Met Leu Gly Arg 
        195                 200                 205             


Ile Cys Gln Glu Met Pro Ser Gly Leu Ala Tyr Ala Leu Asp Ile Ser 
    210                 215                 220                 


Pro Val Val His Arg Ile Tyr Val Ala Gln Val Leu Gly Gln Glu Asp 
225                 230                 235                 240 


Pro Ala Val Leu Tyr His Lys Cys Gln Val Ala Phe Phe Leu Leu Ala 
                245                 250                 255     


Ala Ala Phe Phe Ser Ala Cys Ser Pro Glu Arg Trp Phe Pro Gly Lys 
            260                 265                 270         


Cys His Thr Phe Gly Gln Gly His Gln Leu Phe His Val Phe Leu Val 
        275                 280                 285             


Leu Cys Thr Leu Ala Gln Leu Glu Ala Val Ala Leu Asp Tyr Glu Ala 
    290                 295                 300                 


Arg Arg Ser Ile Tyr Glu Gly Leu His Arg His Ala Leu His Asn Phe 
305                 310                 315                 320 


Ser Ala Leu Phe Leu Leu Thr Val Val Cys Ser Val Leu Thr Ala Leu 
                325                 330                 335     


Phe Leu Ser His Arg Val Arg Gln Glu Leu Arg Cys Lys Glu Asp 
            340                 345                 350     


<210>  70
<211>  341
<212>  PRT
<213>  Gallus gallus

<400>  70

Met Ala Ala Val Val Ala Glu Lys Leu Ser Arg Leu Phe Ile Ser Val 
1               5                   10                  15      


Arg Gln Val Pro Gln Leu Leu Ala Pro Pro Val Pro Thr Thr Val Ser 
            20                  25                  30          


Ser Ser Glu Val Pro Arg Val Phe Trp Lys Pro Tyr Ile His Thr Gly 
        35                  40                  45              


Tyr Arg Pro Val His Gln Thr Trp Arg Tyr Tyr Phe Ser Thr Leu Phe 
    50                  55                  60                  


Gln Gln His Asn Glu Ala Ile Asn Val Trp Thr His Leu Val Ala Thr 
65                  70                  75                  80  


Leu Ile Leu Leu Leu Arg Phe Gln Gln Leu Ser Gln Arg Val Asp Phe 
                85                  90                  95      


Gly Gln Asp Pro His Ala Gln Pro Leu Leu Ile Ile Ile Thr Ala Ser 
            100                 105                 110         


Ile Thr Tyr Leu Thr Phe Ser Thr Leu Ala His Leu Leu Gln Ala Lys 
        115                 120                 125             


Ser Glu Phe Trp His Tyr Ser Phe Phe Phe Met Asp Tyr Val Gly Val 
    130                 135                 140                 


Ala Ile Tyr Gln Tyr Gly Ser Ala Leu Val His Tyr Tyr Tyr Ala Ile 
145                 150                 155                 160 


Glu Pro Ser Trp His Glu Lys Ile Gln Gly Phe Phe Met Pro Thr Ala 
                165                 170                 175     


Ala Leu Leu Ala Trp Leu Ser Cys Ala Gly Ser Cys Tyr Ala Lys Phe 
            180                 185                 190         


Arg Tyr His Gln Ser Ala Gly Leu Leu Gly Arg Leu Cys Gln Glu Met 
        195                 200                 205             


Pro Ser Gly Leu Ala Tyr Leu Leu Asp Ile Ser Pro Val Val His Arg 
    210                 215                 220                 


Ile Cys Thr Ala Ser Pro Ala Glu Arg Thr Asp Pro Ala Leu Leu Tyr 
225                 230                 235                 240 


His Lys Cys Gln Val Leu Phe Phe Leu Ile Gly Ala Phe Phe Phe Ser 
                245                 250                 255     


His Pro Tyr Pro Glu Lys Leu Leu Pro Gly Lys Cys Tyr Phe Phe Gly 
            260                 265                 270         


Gln Ser His Gln Ile Phe His Val Phe Leu Val Leu Cys Thr Leu Ala 
        275                 280                 285             


Gln Ile Glu Ala Val Val Leu Asp Tyr Glu Ser Arg Arg His Ile Tyr 
    290                 295                 300                 


Ser Ser Leu Gln Gly Asp Leu Ala His His Phe Ser Ala Leu Cys Val 
305                 310                 315                 320 


Phe Thr Val Thr Cys Ser Val Leu Thr Ala Ala Tyr Met Ala Arg Lys 
                325                 330                 335     


Val Arg Asp Lys Leu 
            340     


<210>  71
<211>  354
<212>  PRT
<213>  Danio rerio

<400>  71

Met Ala Thr Val Val Met Glu Gln Ile Gly Arg Leu Phe Ile Asn Ala 
1               5                   10                  15      


Gln Gln Leu Arg Gln Ile Pro Arg Phe Leu Glu Ser Ala Phe Pro Lys 
            20                  25                  30          


Leu Pro Cys Thr Val Met Val Ser Asp Val Pro Trp Val Phe Arg Glu 
        35                  40                  45              


Ser His Ile Ile Thr Gly Tyr Arg Pro Pro Asp Gln Asn Trp Arg Tyr 
    50                  55                  60                  


Tyr Phe Leu Thr Leu Phe Gln Arg His Asn Glu Ser Val Asn Val Trp 
65                  70                  75                  80  


Thr His Leu Leu Ala Ser Leu Ile Ile Leu Val Lys Phe Gln Glu Leu 
                85                  90                  95      


Ser Glu Thr Val Asp Phe Leu Arg Asp Pro His Ala Gln Pro Met Phe 
            100                 105                 110         


Ile Leu Leu Leu Ala Ala Phe Thr Tyr Leu Gly Cys Ser Ala Leu Ala 
        115                 120                 125             


His Leu Leu Ser Ala Lys Ser Glu Ile Ser His Tyr Thr Phe Tyr Phe 
    130                 135                 140                 


Leu Asp Tyr Val Gly Val Ala Val Tyr Gln Tyr Gly Ser Ala Leu Ala 
145                 150                 155                 160 


His Phe Tyr Tyr Val Val Glu Glu Glu Trp His Ala Gln Val Arg Thr 
                165                 170                 175     


Phe Phe Leu Pro Ala Ser Ala Phe Leu Ala Trp Leu Ser Cys Thr Gly 
            180                 185                 190         


Cys Cys Tyr Gly Lys Tyr Ala Ser Pro Lys Leu Pro Lys Phe Val His 
        195                 200                 205             


Lys Leu Phe Gln Val Val Pro Ser Gly Leu Ala Tyr Cys Leu Asp Ile 
    210                 215                 220                 


Ser Pro Val Leu His Arg Ile Tyr Arg Cys Tyr Ser Ser Glu His Trp 
225                 230                 235                 240 


Cys Ala Asp Gln Ala Val Val Tyr His Cys Tyr Gln Val Leu Phe Phe 
                245                 250                 255     


Leu Ile Ser Ala Tyr Phe Phe Ser Tyr Pro His Pro Glu Arg Trp Phe 
            260                 265                 270         


Pro Gly Arg Cys Asp Phe Ile Gly Gln Gly His Gln Ile Phe His Val 
        275                 280                 285             


Phe Leu Val Leu Cys Thr Leu Val Gln Ile Glu Ala Val Arg Leu Asp 
    290                 295                 300                 


Tyr Thr Glu Arg Arg Arg Leu Tyr Glu His Leu His Gly Asp Leu Ala 
305                 310                 315                 320 


His Asp Ala Val Ala Leu Phe Ile Phe Thr Ala Cys Cys Ser Ala Leu 
                325                 330                 335     


Thr Ala Phe Tyr Val Arg Lys Arg Val Lys Thr Tyr Leu Glu Glu Lys 
            340                 345                 350         


Gln Glu 
        


<210>  72
<211>  357
<212>  PRT
<213>  Danio rerio

<400>  72

Met Lys Lys Ile Gly Arg Leu Phe Phe Asn Leu Gln Lys Met Met Gln 
1               5                   10                  15      


Ile Pro Gln Met Leu Ser Glu Thr Ile Ser Ser Met Pro Lys Thr Leu 
            20                  25                  30          


Ser Asp Lys Glu Ala Pro Cys Phe Phe Arg Lys His Tyr Ile His Ser 
        35                  40                  45              


Gly Tyr Arg Ala Val His Gln Lys Trp Arg Tyr Tyr Phe Leu Ser Leu 
    50                  55                  60                  


Phe Gln Trp His Asn Glu Ser Ile Asn Val Trp Thr His Leu Leu Gly 
65                  70                  75                  80  


Ala Leu Val Val Leu Leu Arg Ala Val Gln Leu Ala Glu Thr Val Asp 
                85                  90                  95      


Phe Ile Asn Asp Ala His Ser Trp Pro Leu Leu Ile Leu Leu Leu Thr 
            100                 105                 110         


Ser Met Ala Tyr Met Gly Phe Ser Thr Val Ala His Leu Leu Ala Ala 
        115                 120                 125             


Lys Ser Val Phe His His Tyr Ala Phe Phe Phe Leu Asp Tyr Val Gly 
    130                 135                 140                 


Val Ala Leu Tyr Gln Tyr Gly Ser Ala Val Val His Tyr Tyr Tyr Ala 
145                 150                 155                 160 


Ile Glu Glu Ser Trp His Glu Ser Val Arg Gly Cys Phe Met Pro Ile 
                165                 170                 175     


Ala Ser Phe Leu Cys Cys Leu Ser Cys Phe Gly Cys Cys Tyr Gly Thr 
            180                 185                 190         


Tyr Cys Asn Tyr Thr His His Pro Trp Val Arg Lys Val Gly Gln Ile 
        195                 200                 205             


Val Pro Ser Ala Leu Ala Tyr Glu Trp Asp Thr Ser Pro Val Phe His 
    210                 215                 220                 


Arg Leu Val Ile Trp Tyr Pro Phe Trp Val Thr Gly Asp Phe Arg Ser 
225                 230                 235                 240 


Ser Pro Ala Leu Leu Phe His Phe Gly Gln Val Ala Phe Phe Leu Ser 
                245                 250                 255     


Ser Ala Phe Phe Phe Thr His Pro Ile Pro Gln Ser Trp Phe Pro Gly 
            260                 265                 270         


His Cys Asp Phe Leu Gly Gln Gly His Gln Val Phe His Val Leu Ile 
        275                 280                 285             


Phe Leu Cys Thr Val Cys Gln Ile Gln Ala Ser Tyr Leu Asp Tyr Leu 
    290                 295                 300                 


Asn Arg Arg Asp Val Tyr Val Thr Leu His Thr Asn Gly Glu Ala Ser 
305                 310                 315                 320 


Phe Phe Val Leu Leu Phe Ile Leu Thr Leu Val Met Ser Thr Leu Ile 
                325                 330                 335     


Ala Phe Tyr Ile Leu Ala Lys Val Lys Arg Ala Val Ser Asn Thr Glu 
            340                 345                 350         


Lys Gln Arg Lys Glu 
        355         


<210>  73
<211>  354
<212>  PRT
<213>  Homo sapiens

<400>  73

Met Thr Thr Ala Ile Leu Glu Arg Leu Ser Thr Leu Ser Val Ser Gly 
1               5                   10                  15      


Gln Gln Leu Arg Arg Leu Pro Lys Ile Leu Glu Asp Gly Leu Pro Lys 
            20                  25                  30          


Met Pro Cys Thr Val Pro Glu Thr Asp Val Pro Gln Leu Phe Arg Glu 
        35                  40                  45              


Pro Tyr Ile Arg Thr Gly Tyr Arg Pro Thr Gly His Glu Trp Arg Tyr 
    50                  55                  60                  


Tyr Phe Phe Ser Leu Phe Gln Lys His Asn Glu Val Val Asn Val Trp 
65                  70                  75                  80  


Thr His Leu Leu Ala Ala Leu Ala Val Leu Leu Arg Phe Trp Ala Phe 
                85                  90                  95      


Ala Glu Ala Glu Ala Leu Pro Trp Ala Ser Thr His Ser Leu Pro Leu 
            100                 105                 110         


Leu Leu Phe Ile Leu Ser Ser Ile Thr Tyr Leu Thr Cys Ser Leu Leu 
        115                 120                 125             


Ala His Leu Leu Gln Ser Lys Ser Glu Leu Ser His Tyr Thr Phe Tyr 
    130                 135                 140                 


Phe Val Asp Tyr Val Gly Val Ser Val Tyr Gln Tyr Gly Ser Ala Leu 
145                 150                 155                 160 


Ala His Phe Phe Tyr Ser Ser Asp Gln Ala Trp Tyr Asp Arg Phe Trp 
                165                 170                 175     


Leu Phe Phe Leu Pro Ala Ala Ala Phe Cys Gly Trp Leu Ser Cys Ala 
            180                 185                 190         


Gly Cys Cys Tyr Ala Lys Tyr Arg Tyr Arg Arg Pro Tyr Pro Val Met 
        195                 200                 205             


Arg Lys Ile Cys Gln Val Val Pro Ala Gly Leu Ala Phe Ile Leu Asp 
    210                 215                 220                 


Ile Ser Pro Val Ala His Arg Val Ala Leu Cys His Leu Ala Gly Cys 
225                 230                 235                 240 


Gln Glu Gln Ala Ala Trp Tyr His Thr Leu Gln Ile Leu Phe Phe Leu 
                245                 250                 255     


Val Ser Ala Tyr Phe Phe Ser Cys Pro Val Pro Glu Lys Tyr Phe Pro 
            260                 265                 270         


Gly Ser Cys Asp Ile Val Gly His Gly His Gln Ile Phe His Ala Phe 
        275                 280                 285             


Leu Ser Ile Cys Thr Leu Ser Gln Leu Glu Ala Ile Leu Leu Asp Tyr 
    290                 295                 300                 


Gln Gly Arg Gln Glu Ile Phe Leu Gln Arg His Gly Pro Leu Ser Val 
305                 310                 315                 320 


His Met Ala Cys Leu Ser Phe Phe Phe Leu Ala Ala Cys Ser Ala Ala 
                325                 330                 335     


Thr Ala Ala Leu Leu Arg His Lys Val Lys Ala Arg Leu Thr Lys Lys 
            340                 345                 350         


Asp Ser 
        


<210>  74
<211>  354
<212>  PRT
<213>  Monodelphis domestica

<400>  74

Met Thr Thr Ala Ile Leu Glu Arg Leu Ser Thr Leu Ser Val Ser Gly 
1               5                   10                  15      


Gln Gln Leu Arg Arg Leu Pro Lys Leu Leu Glu Asp Gly Phe Pro Lys 
            20                  25                  30          


Met Pro Cys Thr Val Pro Glu Ser Asp Val Pro Gln Leu Phe Arg Glu 
        35                  40                  45              


Pro Tyr Ile His Thr Gly Tyr Arg Pro Thr Gly His Glu Trp Arg Tyr 
    50                  55                  60                  


Tyr Phe Phe Ser Leu Phe Gln Lys His Asn Glu Val Val Asn Val Trp 
65                  70                  75                  80  


Thr His Leu Leu Ala Ala Leu Ala Val Leu Leu Arg Phe Arg Ala Phe 
                85                  90                  95      


Ala Glu Thr Glu Ala Leu Pro Trp Thr Ser Ala His Ser Leu Pro Leu 
            100                 105                 110         


Leu Leu Phe Ile Leu Ser Ser Ile Thr Tyr Leu Thr Cys Ser Leu Leu 
        115                 120                 125             


Ala His Leu Leu Gln Ser Lys Ser Glu Leu Ser His Tyr Thr Phe Tyr 
    130                 135                 140                 


Phe Val Asp Tyr Val Gly Val Ser Val Tyr Gln Tyr Gly Ser Ala Leu 
145                 150                 155                 160 


Ala His Phe Phe Tyr Ser Ser Asp Pro Ala Trp Tyr Glu Arg Phe Trp 
                165                 170                 175     


Leu Phe Phe Leu Pro Ala Ala Ala Phe Cys Gly Trp Leu Ser Cys Ala 
            180                 185                 190         


Gly Cys Cys Tyr Ala Lys Tyr Arg Tyr Arg Arg Pro Tyr Pro Val Met 
        195                 200                 205             


Arg Lys Val Cys Gln Val Val Pro Ala Gly Leu Ala Phe Val Leu Asp 
    210                 215                 220                 


Ile Ser Pro Val Ala His Arg Val Ala Leu Cys His Leu Ser Gly Cys 
225                 230                 235                 240 


Gln Glu Gln Ala Ala Trp Tyr His Thr Leu Gln Ile Phe Phe Phe Leu 
                245                 250                 255     


Val Ser Ala Tyr Phe Phe Ser Cys Pro Val Pro Glu Lys Tyr Phe Pro 
            260                 265                 270         


Gly Ser Cys Asp Ile Val Gly His Gly His Gln Ile Phe His Ala Phe 
        275                 280                 285             


Leu Ser Val Cys Thr Leu Ser Gln Leu Glu Ala Ile Leu Leu Asp Tyr 
    290                 295                 300                 


Gln Gly Arg Gln Glu Ile Phe Leu Gln Arg His Ser Pro Leu Ser Val 
305                 310                 315                 320 


Tyr Leu Ala Cys Leu Ser Phe Phe Leu Leu Ala Ala Cys Ser Gly Thr 
                325                 330                 335     


Thr Ala Ala Phe Leu Arg Arg Lys Ile Lys Ala Gly Leu Thr Lys Lys 
            340                 345                 350         


Asp Ser 
        


<210>  75
<211>  352
<212>  PRT
<213>  Gallus gallus

<400>  75

Met Thr Ala Ile Leu Glu Arg Leu Ser Thr Leu Ser Leu Ser Gly Pro 
1               5                   10                  15      


Gln Leu Ser Arg Leu Pro Arg Leu Leu Glu Asp Gly Phe Pro Lys Met 
            20                  25                  30          


Pro Cys Thr Val Gln Glu Gly Glu Val Pro Gln Leu Phe Arg Glu Pro 
        35                  40                  45              


Tyr Ile His Thr Gly Tyr Arg Pro Thr Gly Gln Asp Trp Arg Tyr Tyr 
    50                  55                  60                  


Phe Leu Ser Leu Phe Gln Lys His Asn Glu Val Val Asn Val Trp Thr 
65                  70                  75                  80  


His Leu Leu Ala Ala Leu Ala Val Leu Leu Arg Phe Lys Ala Phe Val 
                85                  90                  95      


Glu Gly Glu Gln Leu Pro Leu Asp Ala Trp Ser Leu Pro Leu Leu Ile 
            100                 105                 110         


Phe Val Leu Ser Ser Val Thr Tyr Leu Thr Cys Ser Leu Leu Ala His 
        115                 120                 125             


Leu Leu Gln Ser Lys Ser Glu Leu Tyr His Tyr Thr Phe Tyr Phe Val 
    130                 135                 140                 


Asp Tyr Val Gly Val Ser Thr Tyr Gln Tyr Gly Ser Ala Leu Ala His 
145                 150                 155                 160 


Phe Tyr Tyr Ser Ser Asp Gln Ala Trp Tyr Asp Lys Phe Trp Leu Phe 
                165                 170                 175     


Phe Leu Pro Ala Ala Ala Phe Cys Gly Trp Leu Ser Cys Ala Gly Cys 
            180                 185                 190         


Cys Tyr Ala Lys Tyr Arg Tyr Arg Arg Pro Tyr Pro Ile Met Arg Lys 
        195                 200                 205             


Met Cys Gln Val Ile Pro Ala Gly Leu Ala Phe Ile Leu Asp Ile Ser 
    210                 215                 220                 


Pro Val Ala His Arg Val Ile Val Cys His Leu Gly Gly Cys Glu Glu 
225                 230                 235                 240 


Asp Ala Ala Trp Tyr His Thr Tyr Gln Ile Leu Phe Phe Leu Ile Ser 
                245                 250                 255     


Ala Tyr Phe Phe Ser Cys Pro Val Pro Glu Lys Tyr Phe Pro Gly Ser 
            260                 265                 270         


Cys Asp Ile Val Gly His Ala His Gln Ile Phe His Thr Phe Leu Ala 
        275                 280                 285             


Ile Cys Thr Leu Ser Gln Leu Glu Ala Ile Cys Leu Asp Tyr Lys Asn 
    290                 295                 300                 


Arg Gln Glu Ile Phe Leu Lys Arg His Arg Pro Phe Ser Ile Tyr Leu 
305                 310                 315                 320 


Ser Cys Ile Ser Phe Phe Gly Leu Val Ala Cys Ser Ala Ile Thr Ala 
                325                 330                 335     


Tyr Ile Leu Arg Cys Arg Ile Lys Ala Ile Leu Ala Lys Lys Asp Ser 
            340                 345                 350         


<210>  76
<211>  353
<212>  PRT
<213>  Xenopus tropicalis

<400>  76

Met Thr Thr Ala Ile Leu Glu Cys Ile Ser Thr Leu Ser Ile Ser Val 
1               5                   10                  15      


Gln Gln Leu Arg Arg Leu Pro Arg Phe Leu Glu Gly Gly Thr Thr Lys 
            20                  25                  30          


Met Pro Leu Thr Val Lys Asp Ser Asp Val Pro Arg Leu Phe Arg Glu 
        35                  40                  45              


Pro Tyr Ile Gln Thr Gly Tyr Arg Pro Thr Asp Gln Asp Trp Lys Tyr 
    50                  55                  60                  


Tyr Phe Leu Ser Leu Phe Gln Lys His Asn Glu Ser Ile Asn Val Trp 
65                  70                  75                  80  


Thr His Leu Leu Val Ala Leu Ala Val Val Leu Arg Phe Val Ala Leu 
                85                  90                  95      


Val Glu Ala Gly Ser Leu Ser Leu Asp Ile Ile Ser Leu Pro Phe Tyr 
            100                 105                 110         


Leu Tyr Val Leu Ser Ser Leu Thr Tyr Leu Thr Cys Ser Ile Leu Ala 
        115                 120                 125             


His Leu Leu Gln Ser Lys Ser Glu Leu Ala His Tyr Thr Phe Tyr Phe 
    130                 135                 140                 


Met Asp Tyr Val Gly Val Ser Thr Tyr Gln Tyr Gly Ser Ala Leu Ala 
145                 150                 155                 160 


His Tyr Tyr Tyr Ser Ser Asn Gln Ala Trp Tyr Asp Lys Ala Trp Tyr 
                165                 170                 175     


Phe Phe Leu Pro Gly Ala Ala Phe Leu Gly Trp Met Ser Cys Ala Gly 
            180                 185                 190         


Cys Cys Tyr Ala Lys Tyr Cys Tyr Lys Arg Pro Tyr Pro Val Met Arg 
        195                 200                 205             


Lys Ile Phe Gln Val Val Pro Ala Gly Leu Ala Tyr Met Leu Asp Ile 
    210                 215                 220                 


Ser Pro Val Ile His Arg Ile Val Thr Cys His Met Glu Gly Cys Thr 
225                 230                 235                 240 


Asp Lys Ala Ile Trp Val His Ala Leu Gln Ile Ile Phe Phe Leu Ile 
                245                 250                 255     


Ser Ser Tyr Phe Phe Ser Cys Pro Val Pro Glu Lys Tyr Phe Pro Gly 
            260                 265                 270         


Ser Cys Asp Phe Val Gly His Gly His Gln Ile Phe His Val Phe Leu 
        275                 280                 285             


Gly Leu Cys Thr Leu Ser Gln Leu Glu Ala Leu Phe Ile Asp Tyr Gln 
    290                 295                 300                 


Thr Arg His Glu Leu Phe Ser Leu Arg Tyr Ser Ser Asn Gly Thr Leu 
305                 310                 315                 320 


Val Asn Cys Leu Ser Phe Phe Met Leu Ile Leu Cys Ser Thr Gly Thr 
                325                 330                 335     


Ala Met Tyr Ala Arg Arg Arg Ile Lys Asn Lys Leu Ala Arg Lys Glu 
            340                 345                 350         


Leu 
    


<210>  77
<211>  352
<212>  PRT
<213>  Danio rerio

<400>  77

Met Ser Ser Gly Val Leu Gly Arg Leu Ser Thr Leu Thr Leu Ser Leu 
1               5                   10                  15      


Gln Gln Leu Gly Gln Leu Pro His Leu Ser Asn Trp Leu Pro Arg Leu 
            20                  25                  30          


Pro Arg Arg Gln Ala Thr Val His Ala Ser Glu Val Pro Ser Leu Phe 
        35                  40                  45              


Arg Glu Pro Tyr Ile Leu Ser Gly Tyr Arg Pro Val His Gln Glu Trp 
    50                  55                  60                  


Arg Ser Tyr Phe Cys Ser Leu Phe Gln Cys His Asn Glu Leu Leu Asn 
65                  70                  75                  80  


Val Trp Thr His Leu Leu Ala Ile Pro Ala Val Leu Leu Gln Phe Ser 
                85                  90                  95      


Phe Phe Ala Gly Ala Trp Gly Leu Thr Leu Asn Leu Ala Ser Leu Pro 
            100                 105                 110         


Leu Phe Leu Tyr Val Leu Ser Ser Leu Thr Tyr Leu Ser Phe Ser Val 
        115                 120                 125             


Ala Ala His Leu Leu Gln Ser His Ser Glu Leu Ala His Tyr Ser Leu 
    130                 135                 140                 


Phe Phe Val Asp Tyr Val Gly Val Ala Val Tyr Gln Tyr Gly Cys Ser 
145                 150                 155                 160 


Met Gly His Tyr Phe Tyr Cys Ser Glu Pro Glu Trp Arg His Ser Leu 
                165                 170                 175     


Val Gly Val Leu Phe Leu Pro Gly Ala Ala Met Leu Ala Trp Leu Ser 
            180                 185                 190         


Cys Ala Ser Cys Cys Tyr Ser Lys Phe Arg Tyr Arg Arg Pro Tyr Pro 
        195                 200                 205             


Phe His Arg Lys Ile Cys Gln Ile Ile Pro Thr Ser Leu Ala Tyr Leu 
    210                 215                 220                 


Leu Asp Ile Ser Pro Val Ala His Arg Leu Leu Thr Lys Ser Trp Asp 
225                 230                 235                 240 


Glu Pro Val Leu Val Phe His Ala Met Gln Val Ala Phe Phe Leu Leu 
                245                 250                 255     


Ala Ala Leu Phe Phe Ser Cys Pro Val Pro Glu Arg Phe Phe Pro Gly 
            260                 265                 270         


Arg Cys Asp Ile Val Gly His Gly His Gln Ile Phe His Ile Phe Leu 
        275                 280                 285             


Val Leu Cys Thr Met Cys Gln Leu Glu Ala Met Phe Arg Asp Phe Leu 
    290                 295                 300                 


Val His Gln Gln Ser Val Val Asp Ala His Gly Glu His Phe Ile Leu 
305                 310                 315                 320 


Leu Ala Gly Gly Ser Phe Phe Leu Leu Val Leu Cys Ser Ile Leu Thr 
                325                 330                 335     


Ala Val Leu Met Arg Gly Ala Val Gln Arg Gln Leu Arg Lys Lys Asp 
            340                 345                 350         


<210>  78
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Pro Arg Arg Leu Gln Pro Arg Gly Ala Gly Thr Lys Gly Pro Pro 
1               5                   10                  15      


Ala Pro Ala Pro Ala Ala Ser Gly Ala Ala Arg Asn Ser His Ser Ala 
            20                  25                  30          


Ala Ser Arg Asp Pro Pro Ala Ser Ala Lys Pro Leu Leu Arg Trp Asp 
        35                  40                  45              


Glu Val Pro Asp Asp Phe Val Glu Cys Phe Ile Leu Ser Gly Tyr Arg 
    50                  55                  60                  


Arg Leu Pro Cys Thr Ala Gln Glu Cys Leu Ala Ser Val Leu Lys Pro 
65                  70                  75                  80  


Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Ile Pro Leu Leu Leu 
                85                  90                  95      


Phe Leu Ser Lys Phe Cys Arg Leu Phe Phe Leu Ser Gly Gly Asp Val 
            100                 105                 110         


Pro Phe His His Pro Trp Leu Leu Pro Leu Trp Cys Tyr Ala Ser Gly 
        115                 120                 125             


Val Leu Leu Thr Phe Ala Met Ser Cys Thr Ala His Val Phe Ser Cys 
    130                 135                 140                 


Leu Ser Leu Arg Leu Arg Ala Ala Phe Phe Tyr Leu Asp Tyr Ala Ser 
145                 150                 155                 160 


Ile Ser Tyr Tyr Gly Phe Gly Ser Thr Val Ala Tyr Tyr Tyr Tyr Leu 
                165                 170                 175     


Leu Pro Gly Leu Ser Leu Leu Asp Ala Arg Val Met Thr Pro Tyr Leu 
            180                 185                 190         


Gln Gln Arg Leu Gly Trp His Val Asp Cys Thr Arg Leu Ile Ala Ala 
        195                 200                 205             


Tyr Arg Ala Leu Val Leu Pro Val Ala Phe Val Leu Ala Val Ala Cys 
    210                 215                 220                 


Thr Val Ala Cys Cys Lys Ser Arg Thr Asp Trp Cys Thr Tyr Pro Phe 
225                 230                 235                 240 


Ala Leu Arg Thr Phe Val Phe Val Met Pro Leu Ser Met Ala Cys Pro 
                245                 250                 255     


Ile Met Leu Glu Ser Trp Leu Phe Asp Leu Arg Gly Glu Asn Pro Thr 
            260                 265                 270         


Leu Phe Val His Phe Tyr Arg Arg Tyr Phe Trp Leu Val Val Ala Ala 
        275                 280                 285             


Phe Phe Asn Val Ser Lys Ile Pro Glu Arg Ile Gln Pro Gly Leu Phe 
    290                 295                 300                 


Asp Ile Ile Gly His Ser His Gln Leu Phe His Ile Phe Thr Phe Leu 
305                 310                 315                 320 


Ser Ile Tyr Asp Gln Val Tyr Tyr Val Glu Glu Gly Leu Arg Gln Phe 
                325                 330                 335     


Leu Gln Ala Pro Pro Ala Ala Pro Thr Phe Ser Gly Thr Val Gly Tyr 
            340                 345                 350         


Met Leu Leu Leu Val Val Cys Leu Gly Leu Val Ile Arg Lys Phe Leu 
        355                 360                 365             


Asn Ser Ser Glu Phe Cys Ser Lys Lys 
    370                 375         


<210>  79
<211>  376
<212>  PRT
<213>  Monodelphis domestica

<400>  79

Met Pro Leu Arg Leu Gln Pro Arg Gly Ala Gly Thr Lys Asn Pro Ser 
1               5                   10                  15      


Ala Ala Ser Ser Ser Ser Ser Ala Pro Ala Leu Thr Ala Ala Ser Pro 
            20                  25                  30          


Ser Pro Thr Leu Pro Gly Pro Lys Pro Leu Leu Arg Trp Asp Glu Val 
        35                  40                  45              


Pro Asp Asp Phe Val Glu Cys Phe Ile Leu Ser Gly Tyr Arg Arg Leu 
    50                  55                  60                  


Pro Cys Thr Ala Gln Glu Cys Val Ala Ser Val Leu Lys Pro Thr Asn 
65                  70                  75                  80  


Glu Thr Leu Asn Phe Trp Thr His Phe Ile Pro Leu Leu Leu Phe Leu 
                85                  90                  95      


Ser Lys Phe Cys Arg Leu Phe Phe Leu Ser Gly Arg Asp Asp Leu Pro 
            100                 105                 110         


Phe His His Pro Trp Leu Leu Pro Leu Trp Cys Tyr Ala Ser Gly Val 
        115                 120                 125             


Leu Leu Thr Phe Ala Met Ser Cys Thr Ala His Val Phe Ser Cys Leu 
    130                 135                 140                 


Ser Leu Arg Leu Arg Ala Thr Phe Phe Tyr Leu Asp Tyr Ala Ser Ile 
145                 150                 155                 160 


Ser Tyr Tyr Gly Phe Gly Ser Thr Val Ala Tyr Tyr Tyr Tyr Leu Leu 
                165                 170                 175     


Pro Gly Leu Ser Leu Leu Asp Ala Ser Val Met Thr Pro Tyr Val Gln 
            180                 185                 190         


Gln Arg Leu Gly Trp His Val Asp Cys Thr Arg Leu Ile Ala Ala Tyr 
        195                 200                 205             


Arg Ala Leu Val Leu Pro Val Ala Phe Val Leu Ala Val Ala Cys Thr 
    210                 215                 220                 


Val Ala Cys Cys Lys Ser Arg Ser Asp Trp Cys Thr Tyr Pro Phe Ala 
225                 230                 235                 240 


Leu Arg Thr Phe Val Phe Val Met Pro Leu Ser Met Ala Cys Pro Ile 
                245                 250                 255     


Met Leu Glu Ser Trp Leu Phe Asp Leu Arg Gly Glu Asn Pro Thr Leu 
            260                 265                 270         


Phe Val His Phe Tyr Arg Arg Tyr Phe Trp Leu Val Val Ala Ala Phe 
        275                 280                 285             


Phe Asn Val Ser Lys Ile Pro Glu Arg Ile Gln Pro Gly Leu Phe Asp 
    290                 295                 300                 


Ile Ile Gly His Ser His Gln Leu Phe His Ile Phe Thr Phe Leu Ser 
305                 310                 315                 320 


Ile Tyr Asp Gln Met His Tyr Val Glu Glu Gly Leu Arg Gln Phe Leu 
                325                 330                 335     


Glu Ala Pro Pro Ala Ser Pro Thr Phe Ser Gly Thr Val Gly Tyr Met 
            340                 345                 350         


Ile Leu Leu Val Leu Cys Leu Gly Leu Val Ile Arg Lys Phe Leu Asn 
        355                 360                 365             


Val Ala Asp Leu Cys Lys Glu Asp 
    370                 375     


<210>  80
<211>  377
<212>  PRT
<213>  Gallus gallus

<400>  80

Met Ala Arg Arg Leu Gln Pro Arg Gly Ala Gly Thr Lys Gly Pro Pro 
1               5                   10                  15      


Ala Ala Thr Ala Ala Ala Ser Glu Ala Gly Pro Arg Pro His Pro Ser 
            20                  25                  30          


Ala Ala Ala Glu Pro Leu Ala Ser Ala Lys Pro Leu Leu Arg Trp Asp 
        35                  40                  45              


Glu Val Pro Asp Asp Phe Val Glu Cys Phe Ile Leu Ser Gly Tyr Arg 
    50                  55                  60                  


Arg Leu Pro Cys Thr Ala Gln Glu Cys Leu Ala Ser Val Leu Lys Pro 
65                  70                  75                  80  


Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Ile Pro Leu Leu Leu 
                85                  90                  95      


Phe Leu Ser Lys Phe Cys Arg Leu Phe Phe Leu Ser Gly Arg Asp Val 
            100                 105                 110         


Pro Phe His His Pro Trp Leu Leu Pro Leu Trp Cys Tyr Ala Ser Gly 
        115                 120                 125             


Val Leu Leu Thr Phe Ala Met Ser Cys Thr Ala His Val Phe Ser Cys 
    130                 135                 140                 


Leu Ser Leu Arg Leu Arg Ala Ala Phe Phe Tyr Leu Asp Tyr Ala Ser 
145                 150                 155                 160 


Ile Ser Tyr Tyr Gly Phe Ala Ser Thr Val Ala Tyr Ser Tyr Tyr Leu 
                165                 170                 175     


Leu Pro Gly Leu Ser Leu Leu Asp Ala Gly Val Leu Ser Arg Tyr Val 
            180                 185                 190         


Gln Gln Gln Leu Gly Trp Gln Leu Asp Cys Ser Leu Pro Ile Ala Ala 
        195                 200                 205             


Tyr Arg Ala Leu Val Leu Pro Val Ala Leu Ala Leu Ala Val Gly Cys 
    210                 215                 220                 


Thr Ala Ala Cys Cys Arg Ser Arg Ala Ala Cys Cys Ala Tyr Pro Phe 
225                 230                 235                 240 


Ala Val Arg Thr Phe Val Phe Ala Met Pro Leu Ser Met Ala Cys Pro 
                245                 250                 255     


Ile Met Leu Glu Ser Leu Ile Phe Asp Leu Arg Thr Arg Asn Pro Thr 
            260                 265                 270         


Leu Phe Val Tyr Phe Tyr Arg Arg Tyr Phe Trp Leu Leu Val Ala Ala 
        275                 280                 285             


Phe Phe Asn Val Ser Lys Ile Pro Glu Arg Ile Gln Pro Gly Leu Phe 
    290                 295                 300                 


Asp Ile Val Gly His Ser His Gln Leu Phe His Ile Phe Thr Phe Leu 
305                 310                 315                 320 


Ser Ile Tyr Asp Gln Val His Tyr Val Glu Asp Gly Leu Ala Glu Phe 
                325                 330                 335     


Leu Lys Ala Ala Pro Ala Ala Pro Thr Tyr Leu Gly Thr Val Gly Tyr 
            340                 345                 350         


Met Leu Leu Leu Thr Val Cys Leu Ala Val Val Val Arg Arg Phe Leu 
        355                 360                 365             


Asn Val Ala Asp Leu Cys Lys Gln Asp 
    370                 375         


<210>  81
<211>  347
<212>  PRT
<213>  Xenopus tropicalis

<400>  81

Met Pro Leu Gln Ser Tyr Thr Arg Asp Lys Asp Lys Thr Pro Leu Leu 
1               5                   10                  15      


Arg Trp Asp Glu Val Pro Asp Asp Phe Val Glu Cys Phe Ile Leu Ser 
            20                  25                  30          


Gly Tyr Arg Arg Leu His Leu Thr Ala Gln Glu Cys Leu Ala Ser Ile 
        35                  40                  45              


Phe Gln Pro Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Ile Pro 
    50                  55                  60                  


Leu Val Leu Phe Val Ser Lys Phe Tyr His Val Phe Phe Leu Ala Thr 
65                  70                  75                  80  


Glu Leu Pro Phe His His Pro Ala Leu Leu Pro Leu Trp Cys Tyr Ala 
                85                  90                  95      


Ser Gly Val Leu Leu Thr Phe Ala Met Ser Cys Thr Ala His Val Phe 
            100                 105                 110         


Ser Cys Arg Ser Leu Arg Leu Arg Ala Ala Phe Phe Phe Leu Asp Tyr 
        115                 120                 125             


Ala Ser Ile Ser Tyr Tyr Gly Phe Ala Ser Thr Val Ala Tyr Ser Tyr 
    130                 135                 140                 


Tyr Leu Leu Pro Arg Leu Ser Leu Leu Asp Pro Ala Val Met Thr Pro 
145                 150                 155                 160 


Tyr Leu Gln Ser Leu Gly Trp His Gln Val Asp Tyr Ser Met Leu Met 
                165                 170                 175     


Gly Leu Tyr Gly Lys Leu Val Leu Pro Val Ala Phe Ile Leu Ala Val 
            180                 185                 190         


Thr Cys Thr Val Ala Cys Cys Lys Ser Arg Ala Glu Asp Cys Ser Tyr 
        195                 200                 205             


Pro Phe Ala Ile Arg Thr Phe Val Phe Ala Met Pro Leu Ser Met Ala 
    210                 215                 220                 


Cys Pro Val Met Ile Glu Ser Leu Leu Phe Asp Leu Arg Lys Arg Asn 
225                 230                 235                 240 


Pro Thr Leu Phe Val His Phe Tyr Arg Arg Tyr Phe Trp Leu Leu Val 
                245                 250                 255     


Ala Ala Phe Phe Asn Val Ser Lys Ile Pro Glu Arg Ile His Pro Gly 
            260                 265                 270         


Leu Phe Asp Ile Ile Gly His Ser His Gln Leu Phe His Ile Phe Thr 
        275                 280                 285             


Phe Leu Ser Ile Tyr Asp Gln Met His Tyr Val Glu Gln Gly Leu Glu 
    290                 295                 300                 


Leu Phe Leu Lys Ser Pro Ser Ser Pro Pro Thr Leu Gln Gly Thr Ile 
305                 310                 315                 320 


Gly Tyr Met Leu Leu Leu Thr Leu Cys Leu Val Phe Val Val Arg Thr 
                325                 330                 335     


Tyr Leu Lys Gly Leu Ser Asn Thr Lys Gln Asp 
            340                 345         


<210>  82
<211>  374
<212>  PRT
<213>  Danio rerio

<400>  82

Met Trp Ser Leu Pro Leu Val Arg His Thr Asp Val Pro Val Arg Val 
1               5                   10                  15      


Thr Glu Ser Phe Ile Leu Ser Gly Tyr Arg Phe Pro Asn Tyr Ser Leu 
            20                  25                  30          


Arg Gln Cys Leu Ala Ser Ala Phe Arg Pro Thr Asn Glu Thr Gly Asn 
        35                  40                  45              


Phe Trp Thr His Phe Leu Pro Ile Phe Val Phe Ala Phe His Phe Met 
    50                  55                  60                  


Glu Val Phe Thr Trp Glu Lys Val Pro Glu Pro Ser Asp Pro Phe Phe 
65                  70                  75                  80  


Tyr Pro Phe Trp Asn Tyr Phe Leu Gly Val Leu Tyr Leu Leu Leu Ala 
                85                  90                  95      


Ser Ser Leu Ala His Leu Leu Asn Ser Met Ser Leu Ile Ile Arg Glu 
            100                 105                 110         


Ile Cys Phe Phe Val Asp Tyr Gly Thr Ile Ser Ala Tyr Thr Val Gly 
        115                 120                 125             


Ser Ser Leu Ala Tyr Phe Tyr Tyr Ile His Pro Gln Ala Gly Ile Pro 
    130                 135                 140                 


Glu Asn Gly Pro Cys Gly His Asn Ser Ser Glu Arg Lys Ser Leu Asn 
145                 150                 155                 160 


Ser Asp Glu Gln Thr Trp Pro Ser Glu Ser Ser Pro Thr Gln Val Gln 
                165                 170                 175     


Leu Phe Phe Glu Ser Leu Tyr Ile Pro Ser Thr Cys Leu Val Ala Ile 
            180                 185                 190         


Ile Cys Val Leu Thr Cys Cys Asn Thr Arg Gln Arg Trp Arg Lys Tyr 
        195                 200                 205             


Arg Tyr Ala Val Arg Thr Leu Val Phe Leu Leu Pro Phe Phe Val Ser 
    210                 215                 220                 


Ser Thr Pro Val Phe Tyr Arg Leu Leu Ser Leu Ser Ser Asn Ser Thr 
225                 230                 235                 240 


Ser Ser Phe Ser Pro His Leu Ser Ser Thr Met Ala Ala Phe Phe Tyr 
                245                 250                 255     


Arg His Cys Phe Trp Leu Val Val Ser Ala Val Phe Asn Ile Ser Lys 
            260                 265                 270         


Ile Pro Glu Arg Val Ser Pro Gly Asn Phe Asp Ile Trp Gly His Ser 
        275                 280                 285             


His Gln Trp Phe His Cys Cys Thr Phe Leu Ser Ile Leu Asp Glu Leu 
    290                 295                 300                 


His Met Ile Lys Val Glu Ile Arg Ala Leu Leu Leu Asn Pro Met Leu 
305                 310                 315                 320 


Leu Leu Pro Pro Ser Thr Pro Pro Arg Leu Pro Gly Pro Thr Phe Trp 
                325                 330                 335     


Ser Thr Tyr Gly Ile Met Val Leu Leu Gln Gly Cys Ile Ala Ser Ile 
            340                 345                 350         


Ile Ala Trp Phe Gly Trp Gln Ala Tyr Gln Ile Tyr Ala Pro Glu Gln 
        355                 360                 365             


Lys Lys Leu Lys Cys Cys 
    370                 


<210>  83
<211>  1194
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  Metabotropic glutamate receptor 1

<400>  83

Met Val Gly Leu Leu Leu Phe Phe Phe Pro Ala Ile Phe Leu Glu Val 
1               5                   10                  15      


Ser Leu Leu Pro Arg Ser Pro Gly Arg Lys Val Leu Leu Ala Gly Ala 
            20                  25                  30          


Ser Ser Gln Arg Ser Val Ala Arg Met Asp Gly Asp Val Ile Ile Gly 
        35                  40                  45              


Ala Leu Phe Ser Val His His Gln Pro Pro Ala Glu Lys Val Pro Glu 
    50                  55                  60                  


Arg Lys Cys Gly Glu Ile Arg Glu Gln Tyr Gly Ile Gln Arg Val Glu 
65                  70                  75                  80  


Ala Met Phe His Thr Leu Asp Lys Ile Asn Ala Asp Pro Val Leu Leu 
                85                  90                  95      


Pro Asn Ile Thr Leu Gly Ser Glu Ile Arg Asp Ser Cys Trp His Ser 
            100                 105                 110         


Ser Val Ala Leu Glu Gln Ser Ile Glu Phe Ile Arg Asp Ser Leu Ile 
        115                 120                 125             


Ser Ile Arg Asp Glu Lys Asp Gly Ile Asn Arg Cys Leu Pro Asp Gly 
    130                 135                 140                 


Gln Ser Leu Pro Pro Gly Arg Thr Lys Lys Pro Ile Ala Gly Val Ile 
145                 150                 155                 160 


Gly Pro Gly Ser Ser Ser Val Ala Ile Gln Val Gln Asn Leu Leu Gln 
                165                 170                 175     


Leu Phe Asp Ile Pro Gln Ile Ala Tyr Ser Ala Thr Ser Ile Asp Leu 
            180                 185                 190         


Ser Asp Lys Thr Leu Tyr Lys Tyr Phe Leu Arg Val Val Pro Ser Asp 
        195                 200                 205             


Thr Leu Gln Ala Arg Ala Met Leu Asp Ile Val Lys Arg Tyr Asn Trp 
    210                 215                 220                 


Thr Tyr Val Ser Ala Val His Thr Glu Gly Asn Tyr Gly Glu Ser Gly 
225                 230                 235                 240 


Met Asp Ala Phe Lys Glu Leu Ala Ala Gln Glu Gly Leu Cys Ile Ala 
                245                 250                 255     


His Ser Asp Lys Ile Tyr Ser Asn Ala Gly Glu Lys Ser Phe Asp Arg 
            260                 265                 270         


Leu Leu Arg Lys Leu Arg Glu Arg Leu Pro Lys Ala Arg Val Val Val 
        275                 280                 285             


Cys Phe Cys Glu Gly Met Thr Val Arg Gly Leu Leu Ser Ala Met Arg 
    290                 295                 300                 


Arg Leu Gly Val Val Gly Glu Phe Ser Leu Ile Gly Ser Asp Gly Trp 
305                 310                 315                 320 


Ala Asp Arg Asp Glu Val Ile Glu Gly Tyr Glu Val Glu Ala Asn Gly 
                325                 330                 335     


Gly Ile Thr Ile Lys Leu Gln Ser Pro Glu Val Arg Ser Phe Asp Asp 
            340                 345                 350         


Tyr Phe Leu Lys Leu Arg Leu Asp Thr Asn Thr Arg Asn Pro Trp Phe 
        355                 360                 365             


Pro Glu Phe Trp Gln His Arg Phe Gln Cys Arg Leu Pro Gly His Leu 
    370                 375                 380                 


Leu Glu Asn Pro Asn Phe Lys Arg Ile Cys Thr Gly Asn Glu Ser Leu 
385                 390                 395                 400 


Glu Glu Asn Tyr Val Gln Asp Ser Lys Met Gly Phe Val Ile Asn Ala 
                405                 410                 415     


Ile Tyr Ala Met Ala His Gly Leu Gln Asn Met His His Ala Leu Cys 
            420                 425                 430         


Pro Gly His Val Gly Leu Cys Asp Ala Met Lys Pro Ile Asp Gly Ser 
        435                 440                 445             


Lys Leu Leu Asp Phe Leu Ile Lys Ser Ser Phe Ile Gly Val Ser Gly 
    450                 455                 460                 


Glu Glu Val Trp Phe Asp Glu Lys Gly Asp Ala Pro Gly Arg Tyr Asp 
465                 470                 475                 480 


Ile Met Asn Leu Gln Tyr Thr Glu Ala Asn Arg Tyr Asp Tyr Val His 
                485                 490                 495     


Val Gly Thr Trp His Glu Gly Val Leu Asn Ile Asp Asp Tyr Lys Ile 
            500                 505                 510         


Gln Met Asn Lys Ser Gly Val Val Arg Ser Val Cys Ser Glu Pro Cys 
        515                 520                 525             


Leu Lys Gly Gln Ile Lys Val Ile Arg Lys Gly Glu Val Ser Cys Cys 
    530                 535                 540                 


Trp Ile Cys Thr Ala Cys Lys Glu Asn Glu Tyr Val Gln Asp Glu Phe 
545                 550                 555                 560 


Thr Cys Lys Ala Cys Asp Leu Gly Trp Trp Pro Asn Ala Asp Leu Thr 
                565                 570                 575     


Gly Cys Glu Pro Ile Pro Val Arg Tyr Leu Glu Trp Ser Asn Ile Glu 
            580                 585                 590         


Ser Ile Ile Ala Ile Ala Phe Ser Cys Leu Gly Ile Leu Val Thr Leu 
        595                 600                 605             


Phe Val Thr Leu Ile Phe Val Leu Tyr Arg Asp Thr Pro Val Val Lys 
    610                 615                 620                 


Ser Ser Ser Arg Glu Leu Cys Tyr Ile Ile Leu Ala Gly Ile Phe Leu 
625                 630                 635                 640 


Gly Tyr Val Cys Pro Phe Thr Leu Ile Ala Lys Pro Thr Thr Thr Ser 
                645                 650                 655     


Cys Tyr Leu Gln Arg Leu Leu Val Gly Leu Ser Ser Ala Met Cys Tyr 
            660                 665                 670         


Ser Ala Leu Val Thr Lys Thr Asn Arg Ile Ala Arg Ile Leu Ala Gly 
        675                 680                 685             


Ser Lys Lys Lys Ile Cys Thr Arg Lys Pro Arg Phe Met Ser Ala Trp 
    690                 695                 700                 


Ala Gln Val Ile Ile Ala Ser Ile Leu Ile Ser Val Gln Leu Thr Leu 
705                 710                 715                 720 


Val Val Thr Leu Ile Ile Met Glu Pro Pro Met Pro Ile Leu Ser Tyr 
                725                 730                 735     


Pro Ser Ile Lys Glu Val Tyr Leu Ile Cys Asn Thr Ser Asn Leu Gly 
            740                 745                 750         


Val Val Ala Pro Leu Gly Tyr Asn Gly Leu Leu Ile Met Ser Cys Thr 
        755                 760                 765             


Tyr Tyr Ala Phe Lys Thr Arg Asn Val Pro Ala Asn Phe Asn Glu Ala 
    770                 775                 780                 


Lys Tyr Ile Ala Phe Thr Met Tyr Thr Thr Cys Ile Ile Trp Leu Ala 
785                 790                 795                 800 


Phe Val Pro Ile Tyr Phe Gly Ser Asn Tyr Lys Ile Ile Thr Thr Cys 
                805                 810                 815     


Phe Ala Val Ser Leu Ser Val Thr Val Ala Leu Gly Cys Met Phe Thr 
            820                 825                 830         


Pro Lys Met Tyr Ile Ile Ile Ala Lys Pro Glu Arg Asn Val Arg Ser 
        835                 840                 845             


Ala Phe Thr Thr Ser Asp Val Val Arg Met His Val Gly Asp Gly Lys 
    850                 855                 860                 


Leu Pro Cys Arg Ser Asn Thr Phe Leu Asn Ile Phe Arg Arg Lys Lys 
865                 870                 875                 880 


Ala Gly Ala Gly Asn Ala Asn Ser Asn Gly Lys Ser Val Ser Trp Ser 
                885                 890                 895     


Glu Pro Gly Gly Gly Gln Val Pro Lys Gly Gln His Met Trp His Arg 
            900                 905                 910         


Leu Ser Val His Val Lys Thr Asn Glu Thr Ala Cys Asn Gln Thr Ala 
        915                 920                 925             


Val Ile Lys Pro Leu Thr Lys Ser Tyr Gln Gly Ser Gly Lys Ser Leu 
    930                 935                 940                 


Thr Phe Ser Asp Thr Ser Thr Lys Thr Leu Tyr Asn Val Glu Glu Glu 
945                 950                 955                 960 


Glu Asp Ala Gln Pro Ile Arg Phe Ser Pro Pro Gly Ser Pro Ser Met 
                965                 970                 975     


Val Val His Arg Arg Val Pro Ser Ala Ala Thr Thr Pro Pro Leu Pro 
            980                 985                 990         


Pro His Leu Thr Ala Glu Glu Thr  Pro Leu Phe Leu Ala  Glu Pro Ala 
        995                 1000                 1005             


Leu Pro  Lys Gly Leu Pro Pro  Pro Leu Gln Gln Gln  Gln Gln Pro 
    1010                 1015                 1020             


Pro Pro  Gln Gln Lys Ser Leu  Met Asp Gln Leu Gln  Gly Val Val 
    1025                 1030                 1035             


Ser Asn  Phe Ser Thr Ala Ile  Pro Asp Phe His Ala  Val Leu Ala 
    1040                 1045                 1050             


Gly Pro  Gly Gly Pro Gly Asn  Gly Leu Arg Ser Leu  Tyr Pro Pro 
    1055                 1060                 1065             


Pro Pro  Pro Pro Gln His Leu  Gln Met Leu Pro Leu  Gln Leu Ser 
    1070                 1075                 1080             


Thr Phe  Gly Glu Glu Leu Val  Ser Pro Pro Ala Asp  Asp Asp Asp 
    1085                 1090                 1095             


Asp Ser  Glu Arg Phe Lys Leu  Leu Gln Glu Tyr Val  Tyr Glu His 
    1100                 1105                 1110             


Glu Arg  Glu Gly Asn Thr Glu  Glu Asp Glu Leu Glu  Glu Glu Glu 
    1115                 1120                 1125             


Glu Asp  Leu Gln Ala Ala Ser  Lys Leu Thr Pro Asp  Asp Ser Pro 
    1130                 1135                 1140             


Ala Leu  Thr Pro Pro Ser Pro  Phe Arg Asp Ser Val  Ala Ser Gly 
    1145                 1150                 1155             


Ser Ser  Val Pro Ser Ser Pro  Val Ser Glu Ser Val  Leu Cys Thr 
    1160                 1165                 1170             


Pro Pro  Asn Val Ser Tyr Ala  Ser Val Ile Leu Arg  Asp Tyr Lys 
    1175                 1180                 1185             


Gln Ser  Ser Ser Thr Leu 
    1190                 


<210>  84
<211>  1078
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  extracellular calcium receptor

<400>  84

Met Ala Phe Tyr Ser Cys Cys Trp Val Leu Leu Ala Leu Thr Trp His 
1               5                   10                  15      


Thr Ser Ala Tyr Gly Pro Asp Gln Arg Ala Gln Lys Lys Gly Asp Ile 
            20                  25                  30          


Ile Leu Gly Gly Leu Phe Pro Ile His Phe Gly Val Ala Ala Lys Asp 
        35                  40                  45              


Gln Asp Leu Lys Ser Arg Pro Glu Ser Val Glu Cys Ile Arg Tyr Asn 
    50                  55                  60                  


Phe Arg Gly Phe Arg Trp Leu Gln Ala Met Ile Phe Ala Ile Glu Glu 
65                  70                  75                  80  


Ile Asn Ser Ser Pro Ala Leu Leu Pro Asn Leu Thr Leu Gly Tyr Arg 
                85                  90                  95      


Ile Phe Asp Thr Cys Asn Thr Val Ser Lys Ala Leu Glu Ala Thr Leu 
            100                 105                 110         


Ser Phe Val Ala Gln Asn Lys Ile Asp Ser Leu Asn Leu Asp Glu Phe 
        115                 120                 125             


Cys Asn Cys Ser Glu His Ile Pro Ser Thr Ile Ala Val Val Gly Ala 
    130                 135                 140                 


Thr Gly Ser Gly Val Ser Thr Ala Val Ala Asn Leu Leu Gly Leu Phe 
145                 150                 155                 160 


Tyr Ile Pro Gln Val Ser Tyr Ala Ser Ser Ser Arg Leu Leu Ser Asn 
                165                 170                 175     


Lys Asn Gln Phe Lys Ser Phe Leu Arg Thr Ile Pro Asn Asp Glu His 
            180                 185                 190         


Gln Ala Thr Ala Met Ala Asp Ile Ile Glu Tyr Phe Arg Trp Asn Trp 
        195                 200                 205             


Val Gly Thr Ile Ala Ala Asp Asp Asp Tyr Gly Arg Pro Gly Ile Glu 
    210                 215                 220                 


Lys Phe Arg Glu Glu Ala Glu Glu Arg Asp Ile Cys Ile Asp Phe Ser 
225                 230                 235                 240 


Glu Leu Ile Ser Gln Tyr Ser Asp Glu Glu Glu Ile Gln His Val Val 
                245                 250                 255     


Glu Val Ile Gln Asn Ser Thr Ala Lys Val Ile Val Val Phe Ser Ser 
            260                 265                 270         


Gly Pro Asp Leu Glu Pro Leu Ile Lys Glu Ile Val Arg Arg Asn Ile 
        275                 280                 285             


Thr Gly Lys Ile Trp Leu Ala Ser Glu Ala Trp Ala Ser Ser Ser Leu 
    290                 295                 300                 


Ile Ala Met Pro Gln Tyr Phe His Val Val Gly Gly Thr Ile Gly Phe 
305                 310                 315                 320 


Ala Leu Lys Ala Gly Gln Ile Pro Gly Phe Arg Glu Phe Leu Lys Lys 
                325                 330                 335     


Val His Pro Arg Lys Ser Val His Asn Gly Phe Ala Lys Glu Phe Trp 
            340                 345                 350         


Glu Glu Thr Phe Asn Cys His Leu Gln Glu Gly Ala Lys Gly Pro Leu 
        355                 360                 365             


Pro Val Asp Thr Phe Leu Arg Gly His Glu Glu Ser Gly Asp Arg Phe 
    370                 375                 380                 


Ser Asn Ser Ser Thr Ala Phe Arg Pro Leu Cys Thr Gly Asp Glu Asn 
385                 390                 395                 400 


Ile Ser Ser Val Glu Thr Pro Tyr Ile Asp Tyr Thr His Leu Arg Ile 
                405                 410                 415     


Ser Tyr Asn Val Tyr Leu Ala Val Tyr Ser Ile Ala His Ala Leu Gln 
            420                 425                 430         


Asp Ile Tyr Thr Cys Leu Pro Gly Arg Gly Leu Phe Thr Asn Gly Ser 
        435                 440                 445             


Cys Ala Asp Ile Lys Lys Val Glu Ala Trp Gln Val Leu Lys His Leu 
    450                 455                 460                 


Arg His Leu Asn Phe Thr Asn Asn Met Gly Glu Gln Val Thr Phe Asp 
465                 470                 475                 480 


Glu Cys Gly Asp Leu Val Gly Asn Tyr Ser Ile Ile Asn Trp His Leu 
                485                 490                 495     


Ser Pro Glu Asp Gly Ser Ile Val Phe Lys Glu Val Gly Tyr Tyr Asn 
            500                 505                 510         


Val Tyr Ala Lys Lys Gly Glu Arg Leu Phe Ile Asn Glu Glu Lys Ile 
        515                 520                 525             


Leu Trp Ser Gly Phe Ser Arg Glu Val Pro Phe Ser Asn Cys Ser Arg 
    530                 535                 540                 


Asp Cys Leu Ala Gly Thr Arg Lys Gly Ile Ile Glu Gly Glu Pro Thr 
545                 550                 555                 560 


Cys Cys Phe Glu Cys Val Glu Cys Pro Asp Gly Glu Tyr Ser Asp Glu 
                565                 570                 575     


Thr Asp Ala Ser Ala Cys Asn Lys Cys Pro Asp Asp Phe Trp Ser Asn 
            580                 585                 590         


Glu Asn His Thr Ser Cys Ile Ala Lys Glu Ile Glu Phe Leu Ser Trp 
        595                 600                 605             


Thr Glu Pro Phe Gly Ile Ala Leu Thr Leu Phe Ala Val Leu Gly Ile 
    610                 615                 620                 


Phe Leu Thr Ala Phe Val Leu Gly Val Phe Ile Lys Phe Arg Asn Thr 
625                 630                 635                 640 


Pro Ile Val Lys Ala Thr Asn Arg Glu Leu Ser Tyr Leu Leu Leu Phe 
                645                 650                 655     


Ser Leu Leu Cys Cys Phe Ser Ser Ser Leu Phe Phe Ile Gly Glu Pro 
            660                 665                 670         


Gln Asp Trp Thr Cys Arg Leu Arg Gln Pro Ala Phe Gly Ile Ser Phe 
        675                 680                 685             


Val Leu Cys Ile Ser Cys Ile Leu Val Lys Thr Asn Arg Val Leu Leu 
    690                 695                 700                 


Val Phe Glu Ala Lys Ile Pro Thr Ser Phe His Arg Lys Trp Trp Gly 
705                 710                 715                 720 


Leu Asn Leu Gln Phe Leu Leu Val Phe Leu Cys Thr Phe Met Gln Ile 
                725                 730                 735     


Val Ile Cys Val Ile Trp Leu Tyr Thr Ala Pro Pro Ser Ser Tyr Arg 
            740                 745                 750         


Asn Gln Glu Leu Glu Asp Glu Ile Ile Phe Ile Thr Cys His Glu Gly 
        755                 760                 765             


Ser Leu Met Ala Leu Gly Phe Leu Ile Gly Tyr Thr Cys Leu Leu Ala 
    770                 775                 780                 


Ala Ile Cys Phe Phe Phe Ala Phe Lys Ser Arg Lys Leu Pro Glu Asn 
785                 790                 795                 800 


Phe Asn Glu Ala Lys Phe Ile Thr Phe Ser Met Leu Ile Phe Phe Ile 
                805                 810                 815     


Val Trp Ile Ser Phe Ile Pro Ala Tyr Ala Ser Thr Tyr Gly Lys Phe 
            820                 825                 830         


Val Ser Ala Val Glu Val Ile Ala Ile Leu Ala Ala Ser Phe Gly Leu 
        835                 840                 845             


Leu Ala Cys Ile Phe Phe Asn Lys Ile Tyr Ile Ile Leu Phe Lys Pro 
    850                 855                 860                 


Ser Arg Asn Thr Ile Glu Glu Val Arg Cys Ser Thr Ala Ala His Ala 
865                 870                 875                 880 


Phe Lys Val Ala Ala Arg Ala Thr Leu Arg Arg Ser Asn Val Ser Arg 
                885                 890                 895     


Lys Arg Ser Ser Ser Leu Gly Gly Ser Thr Gly Ser Thr Pro Ser Ser 
            900                 905                 910         


Ser Ile Ser Ser Lys Ser Asn Ser Glu Asp Pro Phe Pro Gln Pro Glu 
        915                 920                 925             


Arg Gln Lys Gln Gln Gln Pro Leu Ala Leu Thr Gln Gln Glu Gln Gln 
    930                 935                 940                 


Gln Gln Pro Leu Thr Leu Pro Gln Gln Gln Arg Ser Gln Gln Gln Pro 
945                 950                 955                 960 


Arg Cys Lys Gln Lys Val Ile Phe Gly Ser Gly Thr Val Thr Phe Ser 
                965                 970                 975     


Leu Ser Phe Asp Glu Pro Gln Lys Asn Ala Met Ala His Arg Asn Ser 
            980                 985                 990         


Thr His Gln Asn Ser Leu Glu Ala  Gln Lys Ser Ser Asp  Thr Leu Thr 
        995                 1000                 1005             


Arg His  Gln Pro Leu Leu Pro  Leu Gln Cys Gly Glu  Thr Asp Leu 
    1010                 1015                 1020             


Asp Leu  Thr Val Gln Glu Thr  Gly Leu Gln Gly Pro  Val Gly Gly 
    1025                 1030                 1035             


Asp Gln  Arg Pro Glu Val Glu  Asp Pro Glu Glu Leu  Ser Pro Ala 
    1040                 1045                 1050             


Leu Val  Val Ser Ser Ser Gln  Ser Phe Val Ile Ser  Gly Gly Gly 
    1055                 1060                 1065             


Ser Thr  Val Thr Glu Asn Val  Val Asn Ser 
    1070                 1075             


<210>  85
<211>  930
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  GABA B receptor 1

<400>  85

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile 
                325                 330                 335     


Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn 
            340                 345                 350         


Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr 
        355                 360                 365             


Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly 
    370                 375                 380                 


Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe 
385                 390                 395                 400 


Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu 
                405                 410                 415     


Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala 
            420                 425                 430         


Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys 
        435                 440                 445             


Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln 
    450                 455                 460                 


Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu 
465                 470                 475                 480 


Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp 
                485                 490                 495     


Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met 
            500                 505                 510         


Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala 
        515                 520                 525             


Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly 
    530                 535                 540                 


Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser 
545                 550                 555                 560 


Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln 
                565                 570                 575     


Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile 
            580                 585                 590         


Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys 
        595                 600                 605             


Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser 
    610                 615                 620                 


Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu 
625                 630                 635                 640 


Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn 
                645                 650                 655     


Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly 
            660                 665                 670         


Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His 
        675                 680                 685             


Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu 
    690                 695                 700                 


Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp 
705                 710                 715                 720 


Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr 
                725                 730                 735     


Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser 
            740                 745                 750         


Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp 
        755                 760                 765             


Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile 
    770                 775                 780                 


Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp 
785                 790                 795                 800 


His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu 
                805                 810                 815     


Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala 
            820                 825                 830         


Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu 
        835                 840                 845             


Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu 
    850                 855                 860                 


Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn 
865                 870                 875                 880 


Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu 
                885                 890                 895     


Leu Glu Lys Ile Ile Ala Glu Ser Gly Gly Leu Pro Arg Gly Pro Pro 
            900                 905                 910         


Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu 
        915                 920                 925             


Tyr Lys 
    930 


<210>  86
<211>  330
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  bile acid receptor

<400>  86

Met Thr Pro Asn Ser Thr Gly Glu Val Pro Ser Pro Ile Pro Lys Gly 
1               5                   10                  15      


Ala Leu Gly Leu Ser Leu Ala Leu Ala Ser Leu Ile Ile Thr Ala Asn 
            20                  25                  30          


Leu Leu Leu Ala Leu Gly Ile Ala Trp Asp Arg Arg Leu Arg Ser Pro 
        35                  40                  45              


Pro Ala Gly Cys Phe Phe Leu Ser Leu Leu Leu Ala Gly Leu Leu Thr 
    50                  55                  60                  


Gly Leu Ala Leu Pro Thr Leu Pro Gly Leu Trp Asn Gln Ser Arg Arg 
65                  70                  75                  80  


Gly Tyr Trp Ser Cys Leu Leu Val Tyr Leu Ala Pro Asn Phe Ser Phe 
                85                  90                  95      


Leu Ser Leu Leu Ala Asn Leu Leu Leu Val His Gly Glu Arg Tyr Met 
            100                 105                 110         


Ala Val Leu Arg Pro Leu Gln Pro Pro Gly Ser Ile Arg Leu Ala Leu 
        115                 120                 125             


Leu Leu Thr Trp Ala Gly Pro Leu Leu Phe Ala Ser Leu Pro Ala Leu 
    130                 135                 140                 


Gly Trp Asn His Trp Thr Pro Gly Ala Asn Cys Ser Ser Gln Ala Ile 
145                 150                 155                 160 


Phe Pro Ala Pro Tyr Leu Tyr Leu Glu Val Tyr Gly Leu Leu Leu Pro 
                165                 170                 175     


Ala Val Gly Ala Ala Ala Phe Leu Ser Val Arg Val Leu Ala Thr Ala 
            180                 185                 190         


His Arg Gln Leu Gln Asp Ile Cys Arg Leu Glu Arg Ala Val Cys Arg 
        195                 200                 205             


Asp Glu Pro Ser Ala Leu Ala Arg Ala Leu Thr Trp Arg Gln Ala Arg 
    210                 215                 220                 


Ala Gln Ala Gly Ala Met Leu Leu Phe Gly Leu Cys Trp Gly Pro Tyr 
225                 230                 235                 240 


Val Ala Thr Leu Leu Leu Ser Val Leu Ala Tyr Glu Gln Arg Pro Pro 
                245                 250                 255     


Leu Gly Pro Gly Thr Leu Leu Ser Leu Leu Ser Leu Gly Ser Ala Ser 
            260                 265                 270         


Ala Ala Ala Val Pro Val Ala Met Gly Leu Gly Asp Gln Arg Tyr Thr 
        275                 280                 285             


Ala Pro Trp Arg Ala Ala Ala Gln Arg Cys Leu Gln Gly Leu Trp Gly 
    290                 295                 300                 


Arg Ala Ser Arg Asp Ser Pro Gly Pro Ser Ile Ala Tyr His Pro Ser 
305                 310                 315                 320 


Ser Gln Ser Ser Val Asp Leu Asp Leu Asn 
                325                 330 


<210>  87
<211>  431
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  a-factor receptor

<400>  87

Met Ser Asp Ala Ala Pro Ser Leu Ser Asn Leu Phe Tyr Asp Pro Thr 
1               5                   10                  15      


Tyr Asn Pro Gly Gln Ser Thr Ile Asn Tyr Thr Ser Ile Tyr Gly Asn 
            20                  25                  30          


Gly Ser Thr Ile Thr Phe Asp Glu Leu Gln Gly Leu Val Asn Ser Thr 
        35                  40                  45              


Val Thr Gln Ala Ile Met Phe Gly Val Arg Cys Gly Ala Ala Ala Leu 
    50                  55                  60                  


Thr Leu Ile Val Met Trp Met Thr Ser Arg Ser Arg Lys Thr Pro Ile 
65                  70                  75                  80  


Phe Ile Ile Asn Gln Val Ser Leu Phe Leu Ile Ile Leu His Ser Ala 
                85                  90                  95      


Leu Tyr Phe Lys Tyr Leu Leu Ser Asn Tyr Ser Ser Val Thr Tyr Ala 
            100                 105                 110         


Leu Thr Gly Phe Pro Gln Phe Ile Ser Arg Gly Asp Val His Val Tyr 
        115                 120                 125             


Gly Ala Thr Asn Ile Ile Gln Val Leu Leu Val Ala Ser Ile Glu Thr 
    130                 135                 140                 


Ser Leu Val Phe Gln Ile Lys Val Ile Phe Thr Gly Asp Asn Phe Lys 
145                 150                 155                 160 


Arg Ile Gly Leu Met Leu Thr Ser Ile Ser Phe Thr Leu Gly Ile Ala 
                165                 170                 175     


Thr Val Thr Met Tyr Phe Val Ser Ala Val Lys Gly Met Ile Val Thr 
            180                 185                 190         


Tyr Asn Asp Val Ser Ala Thr Gln Asp Lys Tyr Phe Asn Ala Ser Thr 
        195                 200                 205             


Ile Leu Leu Ala Ser Ser Ile Asn Phe Met Ser Phe Val Leu Val Val 
    210                 215                 220                 


Lys Leu Ile Leu Ala Ile Arg Ser Arg Arg Phe Leu Gly Leu Lys Gln 
225                 230                 235                 240 


Phe Asp Ser Phe His Ile Leu Leu Ile Met Ser Cys Gln Ser Leu Leu 
                245                 250                 255     


Val Pro Ser Ile Ile Phe Ile Leu Ala Tyr Ser Leu Lys Pro Asn Gln 
            260                 265                 270         


Gly Thr Asp Val Leu Thr Thr Val Ala Thr Leu Leu Ala Val Leu Ser 
        275                 280                 285             


Leu Pro Leu Ser Ser Met Trp Ala Thr Ala Ala Asn Asn Ala Ser Lys 
    290                 295                 300                 


Thr Asn Thr Ile Thr Ser Asp Phe Thr Thr Ser Thr Asp Arg Phe Tyr 
305                 310                 315                 320 


Pro Gly Thr Leu Ser Ser Phe Gln Thr Asp Ser Ile Asn Asn Asp Ala 
                325                 330                 335     


Lys Ser Ser Leu Arg Ser Arg Leu Tyr Asp Leu Tyr Pro Arg Arg Lys 
            340                 345                 350         


Glu Thr Thr Ser Asp Lys His Ser Glu Arg Thr Phe Val Ser Glu Thr 
        355                 360                 365             


Ala Asp Asp Ile Glu Lys Asn Gln Phe Tyr Gln Leu Pro Thr Pro Thr 
    370                 375                 380                 


Ser Ser Lys Asn Thr Arg Ile Gly Pro Phe Ala Asp Ala Ser Tyr Lys 
385                 390                 395                 400 


Glu Gly Glu Val Glu Pro Val Asp Met Tyr Thr Pro Asp Thr Ala Ala 
                405                 410                 415     


Asp Glu Glu Ala Arg Lys Phe Trp Thr Glu Asp Asn Asn Asn Leu 
            420                 425                 430     


<210>  88
<211>  382
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  sphingosine-1-phosphate receptor

<400>  88

Met Gly Pro Thr Ser Val Pro Leu Val Lys Ala His Arg Ser Ser Val 
1               5                   10                  15      


Ser Asp Tyr Val Asn Tyr Asp Ile Ile Val Arg His Tyr Asn Tyr Thr 
            20                  25                  30          


Gly Lys Leu Asn Ile Ser Ala Asp Lys Glu Asn Ser Ile Lys Leu Thr 
        35                  40                  45              


Ser Val Val Phe Ile Leu Ile Cys Cys Phe Ile Ile Leu Glu Asn Ile 
    50                  55                  60                  


Phe Val Leu Leu Thr Ile Trp Lys Thr Lys Lys Phe His Arg Pro Met 
65                  70                  75                  80  


Tyr Tyr Phe Ile Gly Asn Leu Ala Leu Ser Asp Leu Leu Ala Gly Val 
                85                  90                  95      


Ala Tyr Thr Ala Asn Leu Leu Leu Ser Gly Ala Thr Thr Tyr Lys Leu 
            100                 105                 110         


Thr Pro Ala Gln Trp Phe Leu Arg Glu Gly Ser Met Phe Val Ala Leu 
        115                 120                 125             


Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile Glu Arg Tyr Ile 
    130                 135                 140                 


Thr Met Leu Lys Met Lys Leu His Asn Gly Ser Asn Asn Phe Arg Leu 
145                 150                 155                 160 


Phe Leu Leu Ile Ser Ala Cys Trp Val Ile Ser Leu Ile Leu Gly Gly 
                165                 170                 175     


Leu Pro Ile Met Gly Trp Asn Cys Ile Ser Ala Leu Ser Ser Cys Ser 
            180                 185                 190         


Thr Val Leu Pro Leu Tyr His Lys His Tyr Ile Leu Phe Cys Thr Thr 
        195                 200                 205             


Val Phe Thr Leu Leu Leu Leu Ser Ile Val Ile Leu Tyr Cys Arg Ile 
    210                 215                 220                 


Tyr Ser Leu Val Arg Thr Arg Ser Arg Arg Leu Thr Phe Arg Lys Asn 
225                 230                 235                 240 


Ile Ser Lys Ala Ser Arg Ser Ser Glu Lys Ser Leu Ala Leu Leu Lys 
                245                 250                 255     


Thr Val Ile Ile Val Leu Ser Val Phe Ile Ala Cys Trp Ala Pro Leu 
            260                 265                 270         


Phe Ile Leu Leu Leu Leu Asp Val Gly Cys Lys Val Lys Thr Cys Asp 
        275                 280                 285             


Ile Leu Phe Arg Ala Glu Tyr Phe Leu Val Leu Ala Val Leu Asn Ser 
    290                 295                 300                 


Gly Thr Asn Pro Ile Ile Tyr Thr Leu Thr Asn Lys Glu Met Arg Arg 
305                 310                 315                 320 


Ala Phe Ile Arg Ile Met Ser Cys Cys Lys Cys Pro Ser Gly Asp Ser 
                325                 330                 335     


Ala Gly Lys Phe Lys Arg Pro Ile Ile Ala Gly Met Glu Phe Ser Arg 
            340                 345                 350         


Ser Lys Ser Asp Asn Ser Ser His Pro Gln Lys Asp Glu Gly Asp Asn 
        355                 360                 365             


Pro Glu Thr Ile Met Ser Ser Gly Asn Val Asn Ser Ser Ser 
    370                 375                 380         


<210>  89
<211>  593
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  parathyroid hormone receptor

<400>  89

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Glu Ser Glu Glu Asp Lys Glu 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Leu Pro Ala Val Phe Val 
                325                 330                 335     


Ala Val Trp Val Ser Val Arg Ala Thr Leu Ala Asn Thr Gly Cys Trp 
            340                 345                 350         


Asp Leu Ser Ser Gly Asn Lys Lys Trp Ile Ile Gln Val Pro Ile Leu 
        355                 360                 365             


Ala Ser Ile Val Leu Asn Phe Ile Leu Phe Ile Asn Ile Val Arg Val 
    370                 375                 380                 


Leu Ala Thr Lys Leu Arg Glu Thr Asn Ala Gly Arg Cys Asp Thr Arg 
385                 390                 395                 400 


Gln Gln Tyr Arg Lys Leu Leu Lys Ser Thr Leu Val Leu Met Pro Leu 
                405                 410                 415     


Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr Thr Glu Val 
            420                 425                 430         


Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met Leu Phe Asn 
        435                 440                 445             


Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe Cys Asn Gly 
    450                 455                 460                 


Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp Thr Leu Ala 
465                 470                 475                 480 


Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser Tyr Ser Tyr 
                485                 490                 495     


Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly Pro Arg Val 
            500                 505                 510         


Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr Ala Thr Thr 
        515                 520                 525             


Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly Thr Pro Ala 
    530                 535                 540                 


Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala Pro Lys Asp 
545                 550                 555                 560 


Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu Glu Ala Ser 
                565                 570                 575     


Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp Glu Thr Val 
            580                 585                 590         


Met 
    


<210>  90
<211>  375
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  estrogen receptor

<400>  90

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  91
<211>  600
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  sucrose receptor

<400>  91

Met Ile Thr Glu Gly Phe Pro Pro Asn Leu Asn Ala Leu Lys Gly Ser 
1               5                   10                  15      


Ser Leu Leu Glu Lys Arg Val Asp Ser Leu Arg Gln Leu Asn Thr Thr 
            20                  25                  30          


Thr Val Asn Gln Leu Leu Gly Leu Pro Gly Met Thr Ser Thr Phe Thr 
        35                  40                  45              


Ala Pro Gln Leu Leu Gln Leu Arg Ile Ile Ala Ile Thr Ala Ser Ala 
    50                  55                  60                  


Val Ser Leu Ile Ala Gly Cys Leu Gly Met Phe Phe Leu Ser Lys Met 
65                  70                  75                  80  


Asp Lys Arg Arg Lys Val Phe Arg His Asp Leu Ile Ala Phe Leu Ile 
                85                  90                  95      


Ile Cys Asp Phe Leu Lys Ala Phe Ile Leu Met Ile Tyr Pro Met Ile 
            100                 105                 110         


Ile Leu Ile Asn Asn Ser Val Tyr Ala Thr Pro Ala Phe Phe Asn Thr 
        115                 120                 125             


Leu Gly Trp Phe Thr Ala Phe Ala Ile Glu Gly Ala Asp Met Ala Ile 
    130                 135                 140                 


Met Ile Phe Ala Ile His Phe Ala Ile Leu Ile Phe Lys Pro Asn Trp 
145                 150                 155                 160 


Lys Trp Arg Asn Lys Arg Ser Gly Asn Met Glu Gly Gly Leu Tyr Lys 
                165                 170                 175     


Lys Arg Ser Tyr Ile Trp Pro Ile Thr Ala Leu Val Pro Ala Ile Leu 
            180                 185                 190         


Ala Ser Leu Ala Phe Ile Asn Tyr Asn Lys Leu Asn Asp Asp Ser Asp 
        195                 200                 205             


Thr Thr Ile Ile Leu Asp Asn Asn Asn Tyr Asn Phe Pro Asp Ser Pro 
    210                 215                 220                 


Arg Gln Gly Gly Tyr Lys Pro Trp Ser Ala Trp Cys Tyr Leu Pro Pro 
225                 230                 235                 240 


Lys Pro Tyr Trp Tyr Lys Ile Val Leu Ser Trp Gly Pro Arg Tyr Phe 
                245                 250                 255     


Ile Ile Ile Phe Ile Phe Ala Val Tyr Leu Ser Ile Tyr Ile Phe Ile 
            260                 265                 270         


Thr Ser Glu Ser Lys Arg Ile Lys Ala Gln Ile Gly Asp Phe Asn His 
        275                 280                 285             


Asn Val Leu Glu Glu Glu Lys Glu Lys Lys Lys Leu Asn Val Asp Asn 
    290                 295                 300                 


Asn Asn Thr Asn Pro Ala Asp Asn Ile Pro Thr Leu Ser Asn Glu Ala 
305                 310                 315                 320 


Phe Thr Pro Ser Gln Gln Phe Ser Gln Glu Arg Val Asn Asn Asn Ala 
                325                 330                 335     


Asp Arg Cys Glu Asn Ser Ser Phe Thr Asn Val Gln Gln His Phe Gln 
            340                 345                 350         


Ala Gln Thr Tyr Lys Gln Met Lys Lys Arg Arg Ala Gln Ile Gln Lys 
        355                 360                 365             


Asn Leu Arg Ala Ile Phe Ile Tyr Pro Leu Ser Tyr Ile Gly Ile Trp 
    370                 375                 380                 


Leu Phe Pro Ile Ile Ala Asp Ala Leu Gln Tyr Asn His Glu Ile Lys 
385                 390                 395                 400 


His Gly Pro Thr Met Trp Val Thr Tyr Ile Asp Thr Cys Val Arg Pro 
                405                 410                 415     


Leu Ser Cys Leu Val Asp Val Ile Val Tyr Leu Phe Lys Glu Lys Pro 
            420                 425                 430         


Trp Asn Tyr Ser Trp Ala Lys Thr Glu Ser Lys Tyr Leu Ile Glu Lys 
        435                 440                 445             


Tyr Ile Leu Lys Gly Glu Leu Gly Glu Lys Glu Ile Leu Lys Phe Cys 
    450                 455                 460                 


His Ser Asn Trp Gly Lys Arg Gly Trp Tyr Tyr Arg Gly Lys Trp Lys 
465                 470                 475                 480 


Lys Arg Lys Cys Trp Lys Tyr Ser Thr Asn Pro Leu Lys Arg Ile Leu 
                485                 490                 495     


Trp Phe Val Glu Arg Phe Phe Lys Gln Leu Phe Glu Leu Lys Leu His 
            500                 505                 510         


Phe Ser Phe Tyr Asp Asn Cys Asp Asp Phe Glu Tyr Trp Glu Asn Tyr 
        515                 520                 525             


Tyr Ser Ala Lys Asp Ser Asn Asp Asn Lys Arg Thr Glu Ser Asp Glu 
    530                 535                 540                 


Thr Lys Thr Asn Ser Ser Asp Arg Ser Leu Pro Ser Asn Ser Leu Glu 
545                 550                 555                 560 


Leu Gln Ala Met Leu Asn Asn Ile Thr Ala Glu Glu Val Glu Val Pro 
                565                 570                 575     


Leu Phe Trp Arg Ile Ile His His Ile Pro Met Leu Gly Gly Ile Asp 
            580                 585                 590         


Leu Asp Glu Leu Asn Arg Leu Leu 
        595                 600 


<210>  92
<211>  477
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  glucagon receptor

<400>  92

Met Pro Pro Cys Gln Pro Gln Arg Pro Leu Leu Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Ala Cys Gln Pro Gln Val Pro Ser Ala Gln Val Met Asp Phe Leu 
            20                  25                  30          


Phe Glu Lys Trp Lys Leu Tyr Gly Asp Gln Cys His His Asn Leu Ser 
        35                  40                  45              


Leu Leu Pro Pro Pro Thr Glu Leu Val Cys Asn Arg Thr Phe Asp Lys 
    50                  55                  60                  


Tyr Ser Cys Trp Pro Asp Thr Pro Ala Asn Thr Thr Ala Asn Ile Ser 
65                  70                  75                  80  


Cys Pro Trp Tyr Leu Pro Trp His His Lys Val Gln His Arg Phe Val 
                85                  90                  95      


Phe Lys Arg Cys Gly Pro Asp Gly Gln Trp Val Arg Gly Pro Arg Gly 
            100                 105                 110         


Gln Pro Trp Arg Asp Ala Ser Gln Cys Gln Met Asp Gly Glu Glu Ile 
        115                 120                 125             


Glu Val Gln Lys Glu Val Ala Lys Met Tyr Ser Ser Phe Gln Val Met 
    130                 135                 140                 


Tyr Thr Val Gly Tyr Ser Leu Ser Leu Gly Ala Leu Leu Leu Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Gly Gly Leu Ser Lys Leu His Cys Thr Arg Asn Ala Ile 
                165                 170                 175     


His Ala Asn Leu Phe Ala Ser Phe Val Leu Lys Ala Ser Ser Val Leu 
            180                 185                 190         


Val Ile Asp Gly Leu Leu Arg Thr Arg Tyr Ser Gln Lys Ile Gly Asp 
        195                 200                 205             


Asp Leu Ser Val Ser Thr Trp Leu Ser Asp Gly Ala Val Ala Gly Cys 
    210                 215                 220                 


Arg Val Ala Ala Val Phe Met Gln Tyr Gly Ile Val Ala Asn Tyr Cys 
225                 230                 235                 240 


Trp Leu Leu Val Glu Gly Leu Tyr Leu His Asn Leu Leu Gly Leu Ala 
                245                 250                 255     


Thr Leu Pro Glu Arg Ser Phe Phe Ser Leu Tyr Leu Gly Ile Gly Trp 
            260                 265                 270         


Gly Ala Pro Met Leu Phe Val Val Pro Trp Ala Val Val Lys Cys Leu 
        275                 280                 285             


Phe Glu Asn Val Gln Cys Trp Thr Ser Asn Asp Asn Met Gly Phe Trp 
    290                 295                 300                 


Trp Ile Leu Arg Phe Pro Val Phe Leu Ala Ile Leu Ile Asn Phe Phe 
305                 310                 315                 320 


Ile Phe Val Arg Ile Val Gln Leu Leu Val Ala Lys Leu Arg Ala Arg 
                325                 330                 335     


Gln Met His His Thr Asp Tyr Lys Phe Arg Leu Ala Lys Ser Thr Leu 
            340                 345                 350         


Thr Leu Ile Pro Leu Leu Gly Val His Glu Val Val Phe Ala Phe Val 
        355                 360                 365             


Thr Asp Glu His Ala Gln Gly Thr Leu Arg Ser Ala Lys Leu Phe Phe 
    370                 375                 380                 


Asp Leu Phe Leu Ser Ser Phe Gln Gly Leu Leu Val Ala Val Leu Tyr 
385                 390                 395                 400 


Cys Phe Leu Asn Lys Glu Val Gln Ser Glu Leu Arg Arg Arg Trp His 
                405                 410                 415     


Arg Trp Arg Leu Gly Lys Val Leu Trp Glu Glu Arg Asn Thr Ser Asn 
            420                 425                 430         


His Arg Ala Ser Ser Ser Pro Gly His Gly Pro Pro Ser Lys Glu Leu 
        435                 440                 445             


Gln Phe Gly Arg Gly Gly Gly Ser Gln Asp Ser Ser Ala Glu Thr Pro 
    450                 455                 460                 


Leu Ala Gly Gly Leu Pro Arg Leu Ala Glu Ser Pro Phe 
465                 470                 475         


<210>  93
<211>  474
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  (AAs 145-414 GPCR domain) calcitonin receptor

<400>  93

Met Arg Phe Thr Phe Thr Ser Arg Cys Leu Ala Leu Phe Leu Leu Leu 
1               5                   10                  15      


Asn His Pro Thr Pro Ile Leu Pro Ala Phe Ser Asn Gln Thr Tyr Pro 
            20                  25                  30          


Thr Ile Glu Pro Lys Pro Phe Leu Tyr Val Val Gly Arg Lys Lys Met 
        35                  40                  45              


Met Asp Ala Gln Tyr Lys Cys Tyr Asp Arg Met Gln Gln Leu Pro Ala 
    50                  55                  60                  


Tyr Gln Gly Glu Gly Pro Tyr Cys Asn Arg Thr Trp Asp Gly Trp Leu 
65                  70                  75                  80  


Cys Trp Asp Asp Thr Pro Ala Gly Val Leu Ser Tyr Gln Phe Cys Pro 
                85                  90                  95      


Asp Tyr Phe Pro Asp Phe Asp Pro Ser Glu Lys Val Thr Lys Tyr Cys 
            100                 105                 110         


Asp Glu Lys Gly Val Trp Phe Lys His Pro Glu Asn Asn Arg Thr Trp 
        115                 120                 125             


Ser Asn Tyr Thr Met Cys Asn Ala Phe Thr Pro Glu Lys Leu Lys Asn 
    130                 135                 140                 


Ala Tyr Val Leu Tyr Tyr Leu Ala Ile Val Gly His Ser Leu Ser Ile 
145                 150                 155                 160 


Phe Thr Leu Val Ile Ser Leu Gly Ile Phe Val Phe Phe Arg Ser Leu 
                165                 170                 175     


Gly Cys Gln Arg Val Thr Leu His Lys Asn Met Phe Leu Thr Tyr Ile 
            180                 185                 190         


Leu Asn Ser Met Ile Ile Ile Ile His Leu Val Glu Val Val Pro Asn 
        195                 200                 205             


Gly Glu Leu Val Arg Arg Asp Pro Val Ser Cys Lys Ile Leu His Phe 
    210                 215                 220                 


Phe His Gln Tyr Met Met Ala Cys Asn Tyr Phe Trp Met Leu Cys Glu 
225                 230                 235                 240 


Gly Ile Tyr Leu His Thr Leu Ile Val Val Ala Val Phe Thr Glu Lys 
                245                 250                 255     


Gln Arg Leu Arg Trp Tyr Tyr Leu Leu Gly Trp Gly Phe Pro Leu Val 
            260                 265                 270         


Pro Thr Thr Ile His Ala Ile Thr Arg Ala Val Tyr Phe Asn Asp Asn 
        275                 280                 285             


Cys Trp Leu Ser Val Glu Thr His Leu Leu Tyr Ile Ile His Gly Pro 
    290                 295                 300                 


Val Met Ala Ala Leu Val Val Asn Phe Phe Phe Leu Leu Asn Ile Val 
305                 310                 315                 320 


Arg Val Leu Val Thr Lys Met Arg Glu Thr His Glu Ala Glu Ser His 
                325                 330                 335     


Met Tyr Leu Lys Ala Val Lys Ala Thr Met Ile Leu Val Pro Leu Leu 
            340                 345                 350         


Gly Ile Gln Phe Val Val Phe Pro Trp Arg Pro Ser Asn Lys Met Leu 
        355                 360                 365             


Gly Lys Ile Tyr Asp Tyr Val Met His Ser Leu Ile His Phe Gln Gly 
    370                 375                 380                 


Phe Phe Val Ala Thr Ile Tyr Cys Phe Cys Asn Asn Glu Val Gln Thr 
385                 390                 395                 400 


Thr Val Lys Arg Gln Trp Ala Gln Phe Lys Ile Gln Trp Asn Gln Arg 
                405                 410                 415     


Trp Gly Arg Arg Pro Ser Asn Arg Ser Ala Arg Ala Ala Ala Ala Ala 
            420                 425                 430         


Ala Glu Ala Gly Asp Ile Pro Ile Tyr Ile Cys His Gln Glu Leu Arg 
        435                 440                 445             


Asn Glu Pro Ala Asn Asn Gln Gly Glu Glu Ser Ala Glu Ile Ile Pro 
    450                 455                 460                 


Leu Asn Ile Ile Glu Gln Glu Ser Ser Ala 
465                 470                 


<210>  94
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward PAQR1 primer

<400>  94
ggtggtggcg accatcacga gaatctttat tttcagggcg acatgtcttc ccacaaagga     60

tc                                                                    62


<210>  95
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse PAQR1 primer

<400>  95
atatctgcag aattccagca cactggcggc cgttactagt ggatcctcag agaagggtgt     60

catcagtac                                                             69


<210>  96
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward PAQR5 primer

<400>  96
ggtggtggcg accatcacga gaatctttat tttcagggcg ccatggtgag cctgaagctc     60

cc                                                                    62


<210>  97
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse PAQR5 primer

<400>  97
atatctgcag aattccagca cactggcggc cgttactagt ggatcctcag agaagggtgt     60

catcagtac                                                             69


<210>  98
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward PAQR6 primer

<400>  98
ggtggtggcg accatcacga gaatctttat tttcagggcg acatgttcag tctcaagctg     60

cc                                                                    62


<210>  99
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse PAQR6 primer

<400>  99
atatctgcag aattccagca cactggcggc cgttactagt ggatccttac tgttgtttgg     60

cctgggtac                                                             69


<210>  100
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward PAQR7 primer

<400>  100
ggtggtggcg accatcacga gaatctttat tttcagggcg acatgtccat ggcccagaaa     60

ct                                                                    62


<210>  101
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse PAQR7 primer

<400>  101
atatctgcag aattccagca cactggcggc cgttactagt ggatcctcac ttggtcttct     60

catcaagtt                                                             69


<210>  102
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward PAQR8 primer

<400>  102
ggtggtggcg accatcacga gaatctttat tttcagggcg acatgtcgac cgccatcttg     60

ga                                                                    62


<210>  103
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse PAQR8 primer

<400>  103
atatctgcag aattccagca cactggcggc cgttactagt ggatcctcag gaatctttct     60

tggtcagtc                                                             69


<210>  104
<211>  62
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward PAQR9 primer

<400>  104
ggtggtggcg accatcacga gaatctttat tttcagggcg ccatggcgcg gcgcctgcag     60

cc                                                                    62


<210>  105
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse PAQR9 primer

<400>  105
atatctgcag aattccagca cactggcggc cgttactagt ggatcctcac tttttactgc     60

agaattcgg                                                             69


<210>  106
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Forward PAQR2 primer

<400>  106
gaattcgata tcaagcttat cgataccgtc gacaatgaac gagccaacag aaaac          55


<210>  107
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Reverse PAQR2 primer

<400>  107
gcgtgacata actaattaca tgactcgagg tcgactcaca gtgcatcctc ttcac          55


<210>  108
<211>  220
<212>  PRT
<213>  Bacillus cereus

<400>  108

Met Arg Gly Val Ile Met Asn Ala Tyr Val Arg Glu Pro Val Asn Ala 
1               5                   10                  15      


Phe Thr His Leu Gly Gly Ala Ile Leu Ser Phe Ile Ala Leu Leu Ala 
            20                  25                  30          


Met Leu Val Lys Val Ser Ile Lys Met Pro Ser Phe Ala Ala Ile Thr 
        35                  40                  45              


Ala Val Ile Leu Phe Gly Ile Gly Met Met Val Leu Tyr Thr Ala Ser 
    50                  55                  60                  


Ala Val Tyr His Ser Val Val Ala Asn Glu Arg Val Ile Tyr Phe Phe 
65                  70                  75                  80  


Arg Lys Leu Asp His Ser Met Ile Phe Ile Leu Ile Ala Gly Thr Tyr 
                85                  90                  95      


Ala Pro Phe Cys Leu Ile Thr Leu Asn Ser Ala Ser Gly Leu Leu Leu 
            100                 105                 110         


Phe Cys Leu Val Tyr Ala Thr Ala Ile Cys Gly Ile Val Phe Lys Met 
        115                 120                 125             


Phe Trp Phe Asn Cys Pro Arg Trp Leu Ser Thr Ala Ile Tyr Ile Thr 
    130                 135                 140                 


Met Gly Trp Leu Ile Val Leu Phe Phe Ala Pro Leu Ala Glu Asn Leu 
145                 150                 155                 160 


Ser Thr Gly Gly Ile Val Phe Leu Val Leu Gly Gly Ile Phe Tyr Thr 
                165                 170                 175     


Ile Gly Gly Phe Ile Tyr Gly Thr Lys Pro Lys Trp Leu Glu Phe Lys 
            180                 185                 190         


Tyr Met Gly His His Glu Ile Phe His Val Phe Val Leu Leu Gly Ser 
        195                 200                 205             


Leu Ala His Phe Leu Ser Val Tyr Cys Tyr Val Ile 
    210                 215                 220 


<210>  109
<211>  236
<212>  PRT
<213>  Bacillus cereus

<400>  109

Met Val Arg Glu Lys Thr Tyr Tyr Phe Met Ile Val Glu Arg Ile Thr 
1               5                   10                  15      


Ile Met Thr Glu Lys Met Thr Arg Met Thr Gln Phe Val Lys Glu Glu 
            20                  25                  30          


Ile Ala Asn Ala Ile Thr His Gly Ile Gly Ala Ile Leu Ser Ile Pro 
        35                  40                  45              


Ala Leu Ile Ile Leu Ile Ile His Ala Ser Lys His Gly Thr Ala Ser 
    50                  55                  60                  


Ala Val Val Ala Phe Thr Val Tyr Gly Val Ser Met Phe Leu Leu Tyr 
65                  70                  75                  80  


Leu Phe Ser Thr Leu Leu His Ser Ile His His Pro Lys Val Glu Lys 
                85                  90                  95      


Leu Phe Thr Ile Leu Asp His Ser Ala Ile Tyr Leu Leu Ile Ala Gly 
            100                 105                 110         


Thr Tyr Thr Pro Phe Leu Leu Ile Thr Leu Arg Gly Pro Leu Gly Trp 
        115                 120                 125             


Thr Leu Leu Ala Ile Ile Trp Thr Leu Ala Ile Gly Gly Ile Ile Phe 
    130                 135                 140                 


Lys Ile Phe Phe Val Arg Arg Phe Ile Lys Ala Ser Thr Leu Cys Tyr 
145                 150                 155                 160 


Ile Ile Met Gly Trp Leu Ile Ile Val Ala Ile Lys Pro Leu Tyr Glu 
                165                 170                 175     


Asn Leu Thr Gly His Gly Phe Ser Leu Leu Leu Ala Gly Gly Ile Leu 
            180                 185                 190         


Tyr Ser Val Gly Ala Ile Phe Phe Leu Trp Glu Lys Leu Pro Phe Asn 
        195                 200                 205             


His Ala Ile Trp His Leu Phe Val Leu Gly Gly Ser Ala Met Met Phe 
    210                 215                 220                 


Phe Cys Val Leu Phe Tyr Val Leu Pro Thr Ala Ser 
225                 230                 235     


<210>  110
<211>  219
<212>  PRT
<213>  Escherichia coli

<400>  110

Met Val Gln Lys Pro Leu Ile Lys Gln Gly Tyr Ser Leu Ala Glu Glu 
1               5                   10                  15      


Ile Ala Asn Ser Val Ser His Gly Ile Gly Leu Val Phe Gly Ile Val 
            20                  25                  30          


Gly Leu Val Leu Leu Leu Val Gln Ala Val Asp Leu Asn Ala Ser Ala 
        35                  40                  45              


Thr Ala Ile Thr Ser Tyr Ser Leu Tyr Gly Gly Ser Met Ile Leu Leu 
    50                  55                  60                  


Phe Leu Ala Ser Thr Leu Tyr His Ala Ile Pro His Gln Arg Ala Lys 
65                  70                  75                  80  


Met Trp Leu Lys Lys Phe Asp His Cys Ala Ile Tyr Leu Leu Ile Ala 
                85                  90                  95      


Gly Thr Tyr Thr Pro Phe Leu Leu Val Gly Leu Asp Ser Pro Leu Ala 
            100                 105                 110         


Arg Gly Leu Met Ile Val Ile Trp Ser Leu Ala Leu Leu Gly Ile Leu 
        115                 120                 125             


Phe Lys Leu Thr Ile Ala His Arg Phe Lys Ile Leu Ser Leu Val Thr 
    130                 135                 140                 


Tyr Leu Ala Met Gly Trp Leu Ser Leu Val Val Ile Tyr Glu Met Ala 
145                 150                 155                 160 


Val Lys Leu Ala Ala Gly Ser Val Thr Leu Leu Ala Val Gly Gly Val 
                165                 170                 175     


Val Tyr Ser Leu Gly Val Ile Phe Tyr Val Cys Lys Arg Ile Pro Tyr 
            180                 185                 190         


Asn His Ala Ile Trp His Gly Phe Val Leu Gly Gly Ser Val Cys His 
        195                 200                 205             


Phe Leu Ala Ile Tyr Leu Tyr Ile Gly Gln Ala 
    210                 215                 


<210>  111
<211>  214
<212>  PRT
<213>  Vibrio vulnificus

<400>  111

Met Ser Val Ser Gln Tyr Ser Val Arg Glu Glu Val Ala Asn Ala Val 
1               5                   10                  15      


Thr His Gly Leu Gly Met Ile Phe Gly Ile Val Gly Leu Val Met Leu 
            20                  25                  30          


Leu Val Lys Ala Thr Glu His His Ala Asp Gly Leu Thr Ile Ala Ser 
        35                  40                  45              


Met Ala Ile Tyr Gly Ser Ser Ile Ile Val Leu Phe Leu Ala Ser Thr 
    50                  55                  60                  


Leu Tyr His Ala Ile Pro Tyr Pro Lys Ala Lys Arg Trp Leu Lys Thr 
65                  70                  75                  80  


Phe Asp His Ser Ala Ile Tyr Leu Leu Ile Ala Gly Ser Tyr Thr Pro 
                85                  90                  95      


Phe Leu Leu Val Ser Leu Arg Thr Pro Leu Ala Ile Gly Leu Met Ile 
            100                 105                 110         


Val Ile Trp Ser Ile Ala Leu Leu Gly Ile Ile Met Lys Val Ala Phe 
        115                 120                 125             


Val Tyr Arg Phe Lys Arg Phe Ser Leu Val Ser Tyr Leu Leu Met Gly 
    130                 135                 140                 


Trp Leu Ser Leu Ile Val Ile Tyr Gln Leu Ala Ile Ser Leu Asp Ile 
145                 150                 155                 160 


Gly Gly Leu Thr Leu Leu Ala Ala Gly Gly Leu Ile Tyr Ser Leu Gly 
                165                 170                 175     


Val Ile Phe Tyr Val Ala Lys Lys Ile Pro Tyr Asn His Ala Ile Trp 
            180                 185                 190         


His Cys Phe Val Leu Val Gly Cys Val Cys His Phe Leu Ala Ile Tyr 
        195                 200                 205             


Leu Tyr Val Asn Pro Val 
    210                 


<210>  112
<211>  543
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  112

Met Met Asp Ser Ser Ser Lys Ser Leu Thr Gln Tyr Ile Pro Ser Pro 
1               5                   10                  15      


Met Gly Ser Leu Ser Arg Leu Lys Gln Lys Gly Val Asp Asn Phe Gln 
            20                  25                  30          


Lys Val Lys Lys Ser Gly Lys Ser Ile Tyr Asn Tyr Asn Tyr Ser Lys 
        35                  40                  45              


Phe Val Pro His Pro Phe Ser Thr Ile Asp Glu Ser Val Lys His Ser 
    50                  55                  60                  


Glu Ser Gly Arg Tyr Asp Asp Leu Glu Ile Ile Arg Pro Thr Lys Glu 
65                  70                  75                  80  


Lys Glu Val Thr Ser Ser Val Tyr Lys Arg Asn Ser Gly Lys Ser Leu 
                85                  90                  95      


Asn Thr Glu Ser Gln Phe Ser Leu Gly Asp Ser Asp Ala Ala Thr Leu 
            100                 105                 110         


Val Asn Ser Val Ala Thr Phe Lys Leu Asn Asn Ala Ser Thr Ser Thr 
        115                 120                 125             


Ser Leu Val Ser Ser Ser Ser Thr Val Cys Ser Gln Ala Lys Ser Ser 
    130                 135                 140                 


Leu Arg Ser Pro Thr Ser Arg Leu Asn Asp Thr Lys Ile Lys Glu Glu 
145                 150                 155                 160 


Asn Asn Tyr Ile Ser Ser Val Lys Asp Tyr Cys Gly Pro Met Arg Lys 
                165                 170                 175     


Ser Met Val Lys Thr Glu Ile Leu Ile Glu Glu Pro Leu Asn Pro Thr 
            180                 185                 190         


Thr Asp Ile Lys Ser Phe Ile Asn Ser Tyr Asn His Gly Lys Ala Tyr 
        195                 200                 205             


Ser Leu Gly Glu Thr Gln His Leu His Tyr Tyr Gln Leu Pro Phe Pro 
    210                 215                 220                 


Trp Arg Glu Asn Arg Tyr Ile Ile His Gly Tyr Arg Phe Tyr Asn Thr 
225                 230                 235                 240 


His Ser Lys Ser Leu Leu Ser Ile Phe Asn Trp Tyr Gly Trp His Asn 
                245                 250                 255     


Glu Thr Ser Asn Ile Trp Ser His Leu Leu Gly Ala Ile Tyr Ile Ile 
            260                 265                 270         


Tyr Leu Ala Ile Tyr Asp Phe Pro Gln Ser Glu Val Trp Arg Asn Ser 
        275                 280                 285             


Gln Val Pro Pro Gln Ala Arg Trp Ile Val Phe Met Phe Leu Ala Ala 
    290                 295                 300                 


Ala Leu Lys Cys Met Leu Ser Ser Val Phe Trp His Thr Phe Asn Gly 
305                 310                 315                 320 


Thr Ser Phe Leu Lys Leu Arg Ser Lys Phe Ala Cys Val Asp Tyr Ser 
                325                 330                 335     


Gly Ile Thr Ile Leu Ile Thr Ala Ser Ile Leu Thr Thr Glu Phe Val 
            340                 345                 350         


Thr Met Tyr Ser Cys Tyr Trp Ala Met Tyr Thr Tyr Met Ser Ile Ser 
        355                 360                 365             


Leu Ala Leu Gly Val Phe Gly Val Phe Met Asn Trp Ser Pro Arg Phe 
    370                 375                 380                 


Asp Arg Pro Glu Ala Arg Pro Leu Arg Ile Arg Phe Phe Ile Leu Leu 
385                 390                 395                 400 


Ala Thr Met Gly Val Leu Ser Phe Leu His Leu Ile Phe Leu Thr Asp 
                405                 410                 415     


Leu His Tyr Ala Ala Thr Leu Phe Ser Pro Val Thr Tyr Lys Ser Val 
            420                 425                 430         


Val Trp Tyr Leu Val Gly Val Val Phe Tyr Gly Ser Phe Ile Pro Glu 
        435                 440                 445             


Arg Phe Arg Ser Asp Val Gln Val Asp Lys Thr Ile Pro Thr Asn Tyr 
    450                 455                 460                 


Glu Leu Ser Thr Asp Leu Glu Ile Ile Thr Lys Gln Arg Glu Ile His 
465                 470                 475                 480 


Phe Arg Glu Val Pro Thr Ala His Ser Lys Cys Ser Ser Cys Pro Ser 
                485                 490                 495     


His Ala Lys Ser Phe Lys Ser Leu Trp Trp Val Asp Tyr Phe Gly Cys 
            500                 505                 510         


Ser His Thr Phe Trp His Phe Phe Val Val Leu Gly Val Ile Gly His 
        515                 520                 525             


Tyr Arg Ala Ile Leu Asp Met Phe Ala Lys Arg Trp Ile Leu Ser 
    530                 535                 540             


<210>  113
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  113

Met His Gln Lys Leu Leu Lys Ser Ala His Tyr Ile Glu Leu Gly Ser 
1               5                   10                  15      


Tyr Gln Tyr Trp Pro Val Leu Val Pro Arg Gly Ile Arg Leu Tyr Thr 
            20                  25                  30          


Tyr Glu Gln Ile Pro Gly Ser Leu Lys Asp Asn Pro Tyr Ile Thr Asp 
        35                  40                  45              


Gly Tyr Arg Ala Tyr Leu Pro Ser Arg Leu Cys Ile Lys Ser Leu Phe 
    50                  55                  60                  


Ile Leu Ser Asn Glu Thr Val Asn Ile Trp Ser His Leu Leu Gly Phe 
65                  70                  75                  80  


Phe Leu Phe Phe Thr Leu Gly Ile Tyr Asp Met Thr Ser Val Leu Pro 
                85                  90                  95      


Ser Ala Ser Ala Ser Arg Glu Asp Phe Val Ile Cys Ser Ile Cys Leu 
            100                 105                 110         


Phe Cys Phe Gln Val Cys Met Leu Cys Ser Val Gly Tyr His Leu Phe 
        115                 120                 125             


Ser Cys His Arg Ser Glu Lys Thr Cys Arg Arg Trp Met Ala Leu Asp 
    130                 135                 140                 


Tyr Ala Gly Ile Ser Ile Gly Ile Leu Gly Cys Tyr Val Ser Gly Val 
145                 150                 155                 160 


Phe Tyr Ala Phe Tyr Cys Asn Asn Tyr Trp Arg Gln Val Tyr Leu Ile 
                165                 170                 175     


Thr Val Leu Ala Met Ile Leu Ala Val Phe Phe Ala Gln Ile His Pro 
            180                 185                 190         


Asn Tyr Leu Thr Gln Gln Trp Gln Arg Leu Arg Ser Ile Ile Phe Cys 
        195                 200                 205             


Ser Val Ser Gly Tyr Gly Val Ile Pro Thr Leu His Trp Val Trp Leu 
    210                 215                 220                 


Asn Gly Gly Ile Gly Ala Pro Ile Val Gln Asp Phe Ala Pro Arg Val 
225                 230                 235                 240 


Ile Val Met Tyr Met Ile Ala Leu Leu Ala Phe Leu Phe Tyr Ile Ser 
                245                 250                 255     


Lys Val Pro Glu Arg Tyr Phe Pro Gly Gln Leu Asn Tyr Leu Gly Ser 
            260                 265                 270         


Ser His Gln Ile Trp His Ile Leu Ala Val Val Met Leu Tyr Trp Trp 
        275                 280                 285             


His Gln Ser Thr Val Tyr Val Met Gln Tyr Arg His Ser Lys Pro Cys 
    290                 295                 300                 


Pro Asp Tyr Val Ser His Leu 
305                 310     


<210>  114
<211>  307
<212>  PRT
<213>  Danio rerio

<400>  114

Met Pro Gln Asn Ile Leu Lys Ser Thr His Tyr Ile Glu Leu Gly Ser 
1               5                   10                  15      


Tyr Gln Tyr Trp Pro Val Leu Val Pro Arg Gly Ile Arg Leu Tyr Thr 
            20                  25                  30          


Tyr Glu Gln Ile Pro Met Phe Leu Lys Glu Asn Pro Tyr Ile Thr Asp 
        35                  40                  45              


Gly Tyr Arg Ala His Leu Pro Ser Lys Leu Cys Leu Lys Ser Ile Phe 
    50                  55                  60                  


Ile Leu Ser Asn Glu Thr Val Asn Ile Trp Ser His Leu Leu Gly Phe 
65                  70                  75                  80  


Leu Leu Phe Phe Ser Leu Gly Val Asn Asp Met Ala Thr Val Leu Pro 
                85                  90                  95      


Ser Ala Gly Ala Ser Arg Glu Asp Tyr Val Ile Tyr Ser Ile Gly Leu 
            100                 105                 110         


Leu Cys Phe Gln Val Cys Met Leu Cys Ser Val Gly Tyr His Leu Phe 
        115                 120                 125             


Cys Cys His Arg Ser Glu Lys Thr Cys Arg Arg Trp Leu Ala Leu Asp 
    130                 135                 140                 


Tyr Ala Gly Ile Ser Val Gly Ile Leu Gly Cys Tyr Val Pro Gly Val 
145                 150                 155                 160 


Phe Tyr Ala Phe Tyr Cys Asn Ser Phe Trp Arg Gln Val Tyr Leu Leu 
                165                 170                 175     


Thr Val Leu Ala Leu Ile Leu Ala Val Phe Ala Ala Gln Ile His Pro 
            180                 185                 190         


Leu Tyr Leu Ser Gln Gln Trp Lys Lys Leu Arg Ser Leu Met Phe Cys 
        195                 200                 205             


Leu Val Ala Ala Tyr Gly Ile Ile Pro Ala Cys His Trp Val Trp Ile 
    210                 215                 220                 


Asn Gly Gly Phe Ser Ser Glu Ile Val Lys Val Phe Phe Pro Arg Val 
225                 230                 235                 240 


Met Ile Met Tyr Leu Ile Ala Ala Ser Ala Phe Leu Phe Tyr Val Ser 
                245                 250                 255     


Lys Ile Pro Glu Arg Tyr Phe Pro Gly Gln Leu Asn Tyr Val Gly Ala 
            260                 265                 270         


Ser His Gln Leu Trp His Val Leu Val Val Val Met Phe Tyr Trp Trp 
        275                 280                 285             


His Gln Thr Ala Val Tyr Ile Met Asn Tyr Arg His Asn Gln Pro Cys 
    290                 295                 300                 


Gly Ser Thr 
305         


<210>  115
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  115

Met Ala Phe Leu Ala Gly Pro Arg Leu Leu Asp Trp Ala Ser Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Pro Ala 
            20                  25                  30          


Ser Ser Gly Ser Gly Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Leu Gly Asn Ile Tyr Thr His Gly Leu Ala Leu Leu Gly Phe Leu Val 
    50                  55                  60                  


Leu Val Pro Met Thr Met Pro Trp Gly Gln Leu Gly Lys Asp Gly Trp 
65                  70                  75                  80  


Leu Gly Gly Thr His Cys Val Ala Cys Leu Ala Pro Pro Ala Gly Ser 
                85                  90                  95      


Val Leu Tyr His Leu Phe Met Cys His Gln Gly Gly Ser Ala Val Tyr 
            100                 105                 110         


Ala Arg Leu Leu Ala Leu Asp Met Cys Gly Val Cys Leu Val Asn Thr 
        115                 120                 125             


Leu Gly Ala Leu Pro Ile Ile His Cys Thr Leu Ala Cys Arg Pro Trp 
    130                 135                 140                 


Leu Arg Pro Ala Ala Leu Val Gly Tyr Thr Val Leu Ser Gly Val Ala 
145                 150                 155                 160 


Gly Trp Arg Ala Leu Thr Ala Pro Ser Thr Ser Ala Arg Leu Arg Ala 
                165                 170                 175     


Phe Gly Trp Gln Ala Ala Ala Arg Leu Leu Val Phe Gly Ala Arg Gly 
            180                 185                 190         


Val Gly Leu Gly Ser Gly Ala Pro Gly Ser Leu Pro Cys Tyr Leu Arg 
        195                 200                 205             


Met Asp Ala Leu Ala Leu Leu Gly Gly Leu Val Asn Val Ala Arg Leu 
    210                 215                 220                 


Pro Glu Arg Trp Gly Pro Gly Arg Phe Asp Tyr Trp Gly Asn Ser His 
225                 230                 235                 240 


Gln Ile Met His Leu Leu Ser Val Gly Ser Ile Leu Gln Leu His Ala 
                245                 250                 255     


Gly Val Val Pro Asp Leu Leu Trp Ala Ala His His Ala Cys Pro Arg 
            260                 265                 270         


Asp 
    


<210>  116
<211>  272
<212>  PRT
<213>  Danio rerio

<400>  116

Met Ala Phe Leu Asn Gly Pro Arg Leu Leu Asp Trp Ala Asn Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Tyr Val Leu Thr Gly Tyr Arg Pro Ile 
            20                  25                  30          


Ser Thr Val Gln Glu Cys Ile Lys Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Leu Gly Asn Ile Tyr Thr His Gly Ile Pro Leu Leu Cys Phe Leu Val 
    50                  55                  60                  


Leu Leu Pro Leu Asn Ile Pro Trp Ser Gln Ile Ser Val Thr Trp Leu 
65                  70                  75                  80  


Gly Val Val His Phe Leu Ala Cys Leu Ser Pro Gln Leu Gly Ser Val 
                85                  90                  95      


Val Tyr His Leu Phe Met Asn His Glu Gly Gly Glu Pro Val Tyr Lys 
            100                 105                 110         


Thr Leu Leu Thr Leu Asp Met Cys Gly Ile Cys Met Ile Asn Thr Leu 
        115                 120                 125             


Gly Ala Leu Pro Ile Val Tyr Ser Thr Leu Leu Cys Tyr Pro Phe Thr 
    130                 135                 140                 


Arg Thr Val Ala Leu Leu Met Tyr Ile Leu Leu Ser Ser Tyr Ala Ile 
145                 150                 155                 160 


Tyr Cys Ala Ile Thr Ala Arg Ser Arg Val Arg Arg Leu Arg Ser Phe 
                165                 170                 175     


Ala Trp Gln Ala Leu Phe Arg Phe Ser Phe Phe Leu Leu Arg Trp Val 
            180                 185                 190         


Gly Val Gly Gly Gly Ser Pro Thr Ser Leu Arg His Phe Leu Thr Met 
        195                 200                 205             


Asp Ala Leu Ala Val Leu Gly Gly Val Ile Asn Ile Thr Arg Ile Pro 
    210                 215                 220                 


Glu Arg Phe Arg Pro Gly Leu Phe Asp Tyr Trp Cys Asn Ser His Gln 
225                 230                 235                 240 


Ile Met His Val Leu Val Val Val Ser Ile Leu Tyr Leu His Trp Gly 
                245                 250                 255     


Val Leu Asp Asp Leu Leu Trp Ile Asn Thr Tyr His Cys Pro Ser Asp 
            260                 265                 270         


<210>  117
<211>  278
<212>  PRT
<213>  Danio rerio

<400>  117

Met Gly Tyr Phe Thr Gly Pro Lys Leu Leu Asp Phe Lys Ser Ser Pro 
1               5                   10                  15      


Pro His Leu Gln Phe Asn Lys Tyr Val His Thr Gly Tyr Arg Pro Ile 
            20                  25                  30          


Ser Thr Cys Arg Glu Cys Leu Arg Ser Leu Phe Tyr Leu His Asn Glu 
        35                  40                  45              


Phe Gly Asn Ile Tyr Thr His Gly Val Pro Phe Ile Cys Phe Leu Leu 
    50                  55                  60                  


Phe Leu Pro Val Ser Ile Pro Trp Ala Glu Val Asp Glu Trp Trp Ile 
65                  70                  75                  80  


Gly Ile Val His Tyr Leu Ala Cys Leu Ser Pro Thr Ile Cys Ser Val 
                85                  90                  95      


Phe Tyr His Leu Phe Met Asn His Glu Gly Gly Ala Pro Ile Tyr Asp 
            100                 105                 110         


Thr Leu Leu Cys Phe Asp Met Phe Gly Val Cys Leu Val Asn Thr Leu 
        115                 120                 125             


Gly Ala Leu Pro Ile Ile His Ile Thr Leu Leu Cys His Pro Ile Thr 
    130                 135                 140                 


Arg Gln Val Ala Met Leu Ala Tyr Leu Leu Leu Ser Gly Tyr Gly Val 
145                 150                 155                 160 


His Cys Ala Leu Thr Ala Glu Ser Asn Ile His Arg Leu Gln Ser Phe 
                165                 170                 175     


Ile Trp Gln Ala Gly Phe Arg Phe Val Leu Phe Met Phe Arg Leu Ile 
            180                 185                 190         


Gly Pro Gly Arg Gly Ser Pro Ser Ser Leu Gln Leu Tyr Leu Thr Met 
        195                 200                 205             


Asp Ala Leu Ala Met Phe Gly Gly Leu Val Asn Val Ser Arg Phe Pro 
    210                 215                 220                 


Glu Arg Phe Ser Pro Gly Arg Phe Asp Tyr Trp Leu Asn Ser His Gln 
225                 230                 235                 240 


Ile Met His Ile Met Val Val Leu Ser Ile Leu Tyr Leu His Trp Gly 
                245                 250                 255     


Met Leu Glu Asp Leu Arg Trp Leu Lys Gly Tyr His Cys Pro Asp Glu 
            260                 265                 270         


Tyr Gly Ile Tyr Asp Ile 
        275             


<210>  118
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Asn His Arg Val Pro Ala His Lys Arg Tyr Gln Pro Thr Glu Tyr 
1               5                   10                  15      


Glu His Ala Ala Asn Cys Ala Thr His Ala Phe Trp Ile Ile Pro Ser 
            20                  25                  30          


Ile Leu Gly Ser Ser Asn Leu Tyr Phe Leu Ser Asp Asp Asp Trp Glu 
        35                  40                  45              


Thr Ile Ser Ala Trp Ile Tyr Gly Leu Gly Leu Cys Gly Leu Phe Val 
    50                  55                  60                  


Val Ser Thr Val Phe His Thr Ile Ser Trp Lys Lys Ser His Leu Arg 
65                  70                  75                  80  


Met Val Glu His Cys Leu His Met Phe Asp Arg Met Val Ile Tyr Phe 
                85                  90                  95      


Phe Ile Ala Ala Ser Tyr Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly 
            100                 105                 110         


Pro Trp Ala Ser His Met Arg Trp Leu Val Trp Ile Met Ala Ser Val 
        115                 120                 125             


Gly Thr Ile Tyr Val Phe Phe Phe His Glu Arg Tyr Lys Leu Val Glu 
    130                 135                 140                 


Leu Leu Cys Tyr Val Val Met Gly Phe Phe Pro Ala Leu Val Ile Leu 
145                 150                 155                 160 


Ser Met Pro Asn Thr Glu Gly Ile Trp Glu Leu Val Thr Gly Gly Val 
                165                 170                 175     


Phe Tyr Cys Leu Gly Met Val Phe Phe Lys Ser Asp Gly Arg Ile Pro 
            180                 185                 190         


Phe Ala His Ala Ile Trp His Leu Phe Val Ala Phe Gly Ala Gly Thr 
        195                 200                 205             


His Tyr Tyr Ala Ile Trp Arg Tyr Leu Tyr Leu Pro Ser Thr Leu Gln 
    210                 215                 220                 


Thr Lys Val Ser Lys 
225                 


<210>  119
<211>  229
<212>  PRT
<213>  Danio rerio

<400>  119

Met Asn Asn Arg Val Pro Ser Ser Lys Arg Tyr Gln Pro Thr Glu Tyr 
1               5                   10                  15      


Glu His Ala Ala Asn Cys Ala Thr His Gly Phe Trp Ile Ile Pro Ser 
            20                  25                  30          


Ile Leu Gly Gly Ser Met Leu His Phe Leu Ser Asp Asp Gln Trp Glu 
        35                  40                  45              


Thr Ile Ser Ala Trp Met Tyr Gly Ile Gly Leu Ser Gly Leu Phe Ile 
    50                  55                  60                  


Met Ser Thr Met Phe His Thr Val Ser Trp Lys Lys Ser His Leu Arg 
65                  70                  75                  80  


Lys Val Glu Gln Arg Phe His Met Cys Asp Arg Met Val Ile Tyr Phe 
                85                  90                  95      


Phe Ile Ala Ala Ser Tyr Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly 
            100                 105                 110         


Pro Trp Ala Val His Met Arg Trp Leu Val Trp Ile Met Ala Cys Ala 
        115                 120                 125             


Gly Ser Ala Tyr Val Phe Phe Phe His Glu Lys Asn Lys Ile Leu Asp 
    130                 135                 140                 


Leu Leu Cys Tyr Thr Ala Met Gly Ser Val Pro Ala Val Val Leu Leu 
145                 150                 155                 160 


Ser Met Pro Asn Arg Glu Gly Val Leu Glu Leu Ser Val Gly Gly Leu 
                165                 170                 175     


Phe Tyr Cys Leu Gly Val Val Phe Phe Lys Ser Asp Gly Leu Ile Pro 
            180                 185                 190         


Phe Ala His Ala Ile Trp His Val Phe Val Ala Val Gly Ala Ala Ile 
        195                 200                 205             


His Tyr Tyr Ala Ile Trp Lys Tyr Leu Tyr Ala Thr Gly Thr Cys Gln 
    210                 215                 220                 


Ile Lys Ile Ser Arg 
225                 


<210>  120
<211>  230
<212>  PRT
<213>  Danio rerio

<400>  120

Met Asn Asn Arg Ala Pro Tyr Asn Lys Arg Tyr Gln Pro Thr Glu Tyr 
1               5                   10                  15      


Glu His Ala Ala Asn Cys Ala Thr His Gly Leu Trp Ile Ile Pro Ser 
            20                  25                  30          


Ile Val Gly Gly Ile Leu Leu Tyr Phe Leu Ser Asp Asp His Trp Glu 
        35                  40                  45              


Glu Ile Ser Ala Trp Leu Tyr Gly Ala Gly Leu Ser Ser Leu Phe Ile 
    50                  55                  60                  


Ile Ser Thr Val Phe His Thr Val Ser Trp Lys Lys Ser His Leu Arg 
65                  70                  75                  80  


Arg Ser Val Glu His Cys Phe His Met Cys Asp Arg Met Val Ile Tyr 
                85                  90                  95      


Phe Phe Ile Ala Ala Ser Tyr Thr Pro Trp Leu Thr Leu Arg Asp Leu 
            100                 105                 110         


Gly Pro Trp Ala Ala His Met Arg Trp Val Val Trp Val Met Ala Ser 
        115                 120                 125             


Gly Gly Thr Ala Tyr Val Phe Phe Phe His Glu Lys Phe Lys Val Val 
    130                 135                 140                 


Glu Leu Ile Cys Tyr Ile Ala Met Gly Val Phe Pro Ala Leu Val Ile 
145                 150                 155                 160 


Leu Ser Met Ala Asp Arg Ser Gly Leu Cys Glu Leu Leu Leu Gly Gly 
                165                 170                 175     


Gly Cys Tyr Val Leu Gly Met Ala Phe Phe Lys Ser Asp Gly Ile Val 
            180                 185                 190         


Pro Phe Ala His Ala Ile Trp His Leu Phe Val Ala Met Gly Ala Gly 
        195                 200                 205             


Ile His Tyr Tyr Ala Ile Trp Lys Tyr Leu Tyr Thr Pro Val Asn Gln 
    210                 215                 220                 


Pro Thr Ser Thr Ala Arg 
225                 230 


<210>  121
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Asn His Arg Ala Pro Ala Asn Gly Arg Tyr Lys Pro Thr Cys Tyr 
1               5                   10                  15      


Glu His Ala Ala Asn Cys Tyr Thr His Ala Phe Leu Ile Val Pro Ala 
            20                  25                  30          


Ile Val Gly Ser Ala Leu Leu His Arg Leu Ser Asp Asp Cys Trp Glu 
        35                  40                  45              


Lys Ile Thr Ala Trp Ile Tyr Gly Met Gly Leu Cys Ala Leu Phe Ile 
    50                  55                  60                  


Ala Ser Thr Val Phe His Ile Val Ser Trp Lys Lys Ser His Leu Arg 
65                  70                  75                  80  


Thr Ala Glu His Cys Phe His Met Cys Asp Arg Met Val Ile Tyr Phe 
                85                  90                  95      


Phe Ile Ala Ala Ser Tyr Ala Pro Trp Leu Asn Leu Arg Glu Leu Gly 
            100                 105                 110         


Pro Leu Ala Ser His Met Arg Trp Phe Ile Trp Leu Met Ala Ala Gly 
        115                 120                 125             


Gly Thr Ile Tyr Val Phe Leu Tyr His Glu Lys Tyr Lys Val Val Glu 
    130                 135                 140                 


Leu Phe Phe Tyr Leu Thr Met Gly Phe Ser Pro Ala Leu Val Val Thr 
145                 150                 155                 160 


Ser Met Asn Asn Thr Asp Gly Leu Gln Glu Leu Ala Cys Gly Gly Leu 
                165                 170                 175     


Ile Tyr Cys Leu Gly Val Val Phe Phe Lys Ser Asp Gly Ile Ile Pro 
            180                 185                 190         


Phe Ala His Ala Ile Trp His Leu Phe Val Ala Thr Ala Ala Ala Val 
        195                 200                 205             


His Tyr Tyr Ala Ile Trp Lys Tyr Leu Tyr Arg Ser Pro Thr Asp Phe 
    210                 215                 220                 


Met Arg His Leu 
225             


<210>  122
<211>  239
<212>  PRT
<213>  Danio rerio

<400>  122

Met Lys Arg Val Asn Ser Phe Gln Arg Phe Met Asn Thr Arg Ala Ala 
1               5                   10                  15      


Ala Asn Cys Arg Tyr Gln Pro Thr Cys Tyr Glu His Ala Ala Asn Cys 
            20                  25                  30          


Tyr Thr His Ala Leu Leu Ile Thr Pro Ala Phe Val Gly Met Ala Leu 
        35                  40                  45              


Leu His Arg Leu Ser Asp Asp Arg Trp Glu Arg Phe Thr Ala Trp Val 
    50                  55                  60                  


Tyr Gly Met Gly Leu Ile Ala Leu Phe Leu Val Ser Thr Val Phe His 
65                  70                  75                  80  


Ile Ile Ser Trp Lys Lys Ser His Met Arg Thr Met Glu His Cys Phe 
                85                  90                  95      


His Met Cys Asp Arg Val Val Ile Tyr Phe Phe Ile Ala Ala Ser Tyr 
            100                 105                 110         


Thr Thr Trp Leu Asn Leu Arg Glu Leu Gly Pro Leu Ala Ala His Met 
        115                 120                 125             


Arg Trp Phe Val Trp Leu Met Ala Ala Ala Gly Thr Ile Tyr Val Phe 
    130                 135                 140                 


Asn Tyr His Glu Lys Tyr Lys Leu Val Glu Leu Met Phe Tyr Leu Thr 
145                 150                 155                 160 


Met Gly Phe Phe Pro Ala Leu Val Val Thr Ser Thr Thr Asn Thr Glu 
                165                 170                 175     


Gly Leu Ser Glu Leu Ala Phe Gly Gly Leu Val Tyr Cys Leu Gly Val 
            180                 185                 190         


Phe Phe Phe Lys Cys Asp Gly Val Ile Pro Phe Ala His Ala Ile Trp 
        195                 200                 205             


His Val Phe Val Ala Leu Ala Ala Ala Ile His Tyr Tyr Ala Ile Trp 
    210                 215                 220                 


Lys Tyr Leu Tyr Arg Ser Pro Ala Leu Glu Asp Ile Arg Asp Ala 
225                 230                 235                 


<210>  123
<211>  241
<212>  PRT
<213>  Entamoeba histolytica

<400>  123

Met Cys Phe Leu Cys Asp Ile Gln Thr Ala Arg Asn Gln Leu Thr Pro 
1               5                   10                  15      


His Asp Glu Arg Pro Gln Cys Leu Leu Glu Glu Gly Val Asn Val Leu 
            20                  25                  30          


Thr His Leu Phe Gly Ile Phe Tyr Ala Ile Phe Ile Phe Lys Met Phe 
        35                  40                  45              


Arg Arg Tyr Ala Lys Lys His Asn Leu Asn Lys Met Asn Asn Leu Ala 
    50                  55                  60                  


Ile Leu Cys Phe Cys Leu Ala Ser Phe Thr Leu Tyr Phe Asn Ser Thr 
65                  70                  75                  80  


Thr Tyr His Leu Leu Asn Ile Leu Leu Pro Asn Ser Ile Cys Leu Arg 
                85                  90                  95      


Tyr Phe Phe Gln Arg Leu Asp His Ile Thr Ile Tyr Ile Met Ile Ser 
            100                 105                 110         


Gly Cys Tyr Leu Cys Phe Ile Phe Thr Arg Thr Phe Ala Lys Gly Tyr 
        115                 120                 125             


Phe Lys Thr Gly Cys Leu Ala Ile Phe Ile Val Val Ala Leu Ala Leu 
    130                 135                 140                 


Ile Gly Phe Ile Phe Thr Ile Phe Ala Pro Pro Thr Thr Arg Thr Asp 
145                 150                 155                 160 


Val Ile Met Tyr Leu Ala Met Gly Trp Ser Cys Val Leu Tyr Gly Pro 
                165                 170                 175     


Leu Val Phe Tyr Phe Cys Pro Leu Ser Leu Val Phe Tyr Leu Leu Thr 
            180                 185                 190         


Gly Gly Ile Ser Tyr Ala Ile Gly Thr Ile Phe Val Ala Trp Asp Gln 
        195                 200                 205             


Leu Phe Phe Asn His Gly Ile Trp His Leu Ile Val Trp Phe Ala Asn 
    210                 215                 220                 


Phe Gln His Ser Leu Gly Val Leu Met Gln Leu Met Thr Lys Arg Leu 
225                 230                 235                 240 


Lys 
    


<210>  124
<211>  340
<212>  PRT
<213>  Ciona intestinalis

<400>  124

Met Gly Cys Cys Asn Ala Val Arg Ser Ser Lys Cys Asp Glu Tyr Pro 
1               5                   10                  15      


Val Gln Tyr Arg Thr Asp Phe Ile Arg Thr Gly Tyr Arg Pro Leu Pro 
            20                  25                  30          


Leu Ser Phe Lys Glu Cys Ile Lys Ser Ala Phe Tyr Ala Asn Asn Glu 
        35                  40                  45              


Thr Gly Asn Ile Trp Thr His Phe Ile Pro Phe Leu Phe Met Val His 
    50                  55                  60                  


Arg Ala Tyr Asn Ile Ile Ser Lys Phe Glu Asp Leu Thr Asp Pro Ile 
65                  70                  75                  80  


Asn Phe Gly Tyr Tyr Val His Ser Ile Gly Val Thr Tyr Val Leu Ile 
                85                  90                  95      


Ala Ser Thr Ile Ala His Thr Phe Cys Thr His Ser Glu Leu Cys Phe 
            100                 105                 110         


Arg Lys Cys Tyr Ser Val Asp Arg Ala Ala Ile Ile Met Gln Gly Phe 
        115                 120                 125             


Ser Val Gln Leu Val Leu Glu Leu Phe Ile Cys Pro Pro Ser Cys Tyr 
    130                 135                 140                 


Val Ala Glu Asp Ile Gly Arg Asn Ser His Val Ile Leu Thr Leu Tyr 
145                 150                 155                 160 


Cys Val Leu Ser Thr Ile Met Phe Cys Ser Ser Val His Pro Arg Leu 
                165                 170                 175     


Gly Arg Phe Gln Arg Phe Leu Ala Val Phe Pro Phe Gly Ile Gly Ser 
            180                 185                 190         


Ile Met Ile Asn Phe Ser Cys Ala Val Arg Tyr Leu Tyr Ser Ser Asn 
        195                 200                 205             


Ala Ile Glu Ser Thr Cys Phe Gly Thr Thr Lys Gly Asp His Val Leu 
    210                 215                 220                 


Phe His Leu His Leu Ile Ala Val Cys Phe Ala Met Phe Phe Tyr Val 
225                 230                 235                 240 


Ala Lys Leu Pro Glu Arg Trp Tyr Pro Glu Lys Phe Asp Ile Val Gly 
                245                 250                 255     


Ser Ser His Gln Ile Phe His Ile Leu Val Ala Ile Ser Leu Tyr Phe 
            260                 265                 270         


Gln Asn Arg Leu Ile Glu His Val Thr Ala Glu Ala Lys Phe Lys Ile 
        275                 280                 285             


Glu Thr Gly Glu Leu Leu Arg Glu Pro Leu Ala Ser Ala Cys Thr Gln 
    290                 295                 300                 


Thr Val Gly Val Phe Ile Leu Thr Phe Ile Thr Val His Ser Val Val 
305                 310                 315                 320 


Ala Leu Tyr Tyr Trp Lys Val Gln Pro Pro Ile Gln Ile Cys Lys Pro 
                325                 330                 335     


Pro Glu Lys Lys 
            340 


<210>  125
<211>  387
<212>  PRT
<213>  Ciona intestinalis

<400>  125

Met Leu Glu Ser Tyr Tyr Cys Val Phe Val Cys Lys Val Ser Ser Cys 
1               5                   10                  15      


Cys Val Asn Phe Asn Tyr Ser Ser Ser Ser Leu Val Thr Arg Arg Ser 
            20                  25                  30          


Leu Trp Asp Thr Trp Leu Arg Ser Tyr Gly Leu Lys Pro Lys Ala Glu 
        35                  40                  45              


Thr Ala Glu Cys Tyr His Glu Ser Phe Ile Leu His Gly Tyr Arg Pro 
    50                  55                  60                  


Thr Pro Ser Ser Val Leu Tyr Cys Val Lys Ser Leu Phe His Pro Thr 
65                  70                  75                  80  


Asn Glu Thr Leu Asn Val Trp Thr His Leu Ile Pro Phe Val Ile Ala 
                85                  90                  95      


Ala Thr Arg His Phe Lys Phe Ala Asn Glu Ile Met Thr Glu Arg Gly 
            100                 105                 110         


Tyr Thr Asp Pro Leu Phe Tyr Pro Tyr Trp Phe Phe Val Leu Gly Val 
        115                 120                 125             


Val Leu Thr Phe Phe Gly Ser Ser Leu Ala His Thr Phe Asn Cys Leu 
    130                 135                 140                 


Thr Pro Gly Ala Arg Glu Ala Cys Phe Cys Cys Asp Tyr Gly Cys Ile 
145                 150                 155                 160 


Ala Ile Gln Cys Ile Gly Leu Ala Thr Cys Phe Thr Phe Tyr Ile Cys 
                165                 170                 175     


Pro Tyr Thr Cys Val Ile Pro His Thr Gly Ser Tyr His Leu Ala Tyr 
            180                 185                 190         


Phe Ala Ile Ile Val Gly Ser Met Met Ala Val Pro Ile Val Cys Tyr 
        195                 200                 205             


Ser Arg Leu Pro Tyr Val Pro Tyr Arg Tyr Val Leu Arg Ile Ala Val 
    210                 215                 220                 


Tyr Val Val Leu Tyr Thr Ser Leu Cys Leu Pro Cys Phe Tyr Lys Tyr 
225                 230                 235                 240 


Leu Thr Phe Thr Pro Glu Pro Gln Phe Lys Thr Cys Gly Ile Ala Ile 
                245                 250                 255     


Gly Asp Glu Ser Arg Arg Asn Phe Phe Glu Leu Thr Cys Ile Met Ala 
            260                 265                 270         


Leu Ser Ala Thr Val Asn Gly Leu Arg Phe Pro Glu Arg Ile Leu Pro 
        275                 280                 285             


Gly Trp Phe Asp Ile Val Gly His Ser His Gln Ile Phe His Val Leu 
    290                 295                 300                 


Ile Ala Gly Gly Leu Tyr Tyr Gln Asn Lys Phe Ile Glu Gly Ala Leu 
305                 310                 315                 320 


Arg Glu Ile Leu Gly Arg Leu Asp Glu Gly Thr Leu Ser Val Asp Asp 
                325                 330                 335     


Leu Asn Ile Thr Trp Tyr Ser Ala Phe Leu Phe Pro Ala Met Asn Gly 
            340                 345                 350         


Leu Ile Ser Met Val Leu Thr Phe Val Phe Ser Val Val Leu Cys Arg 
        355                 360                 365             


Arg Gln Asn Leu Gln Phe Gly Glu Asn Cys Gln Lys Asn Lys Ser Lys 
    370                 375                 380                 


Lys Ala Gln 
385         


<210>  126
<211>  339
<212>  PRT
<213>  Ciona intestinalis

<400>  126

Met Pro Glu Tyr Glu Lys Tyr Val Cys Ser Arg Ala Gly Val Pro Ser 
1               5                   10                  15      


Cys Phe His Gln Asn Phe Val Asn Thr Gly Tyr Arg Arg Glu Ser Gly 
            20                  25                  30          


Ser Ile Leu Thr Cys Leu Gln Ser Ala Phe Trp Pro Thr Asn Glu Thr 
        35                  40                  45              


Phe Asn Phe Trp Thr His Phe Val Ala Ser Ile Met Leu Met Ser Arg 
    50                  55                  60                  


Thr Gly Arg Ile Ile Ser Glu Phe Glu Thr Pro Phe Glu Ala Leu His 
65                  70                  75                  80  


Leu Pro Phe Tyr Ile His Ser Phe Gly Ser Cys Tyr Leu Leu Val Val 
                85                  90                  95      


Ser Ser Phe Ala His Leu Phe Cys Cys Tyr Ser Glu Arg Cys Cys His 
            100                 105                 110         


Arg Cys Phe Ala Val Asp Gln Ala Ala Val Val Leu Tyr Ala Leu Cys 
        115                 120                 125             


Val Leu Leu Gly Phe Glu His Leu Thr Cys Pro Met Ser Cys Tyr Gly 
    130                 135                 140                 


Pro Phe Asn Asp Leu Ser Arg Ala Val Tyr Met Gly Cys Val Val Ile 
145                 150                 155                 160 


Leu Thr Val Leu His Thr Met Phe Ser Val Gln Thr Ser His Ser Ser 
                165                 170                 175     


Tyr Ser Pro Ala Leu Arg Ser Leu Pro Cys Thr Leu Met Thr Leu Leu 
            180                 185                 190         


Ile Ile Leu Pro Cys Ile Val Arg Val Thr Met Asn Ile Asp Glu Pro 
        195                 200                 205             


Gly Cys Phe Pro Thr Thr Asn Lys Ser Tyr Asp Tyr Phe Ala Ala Val 
    210                 215                 220                 


Cys Phe Leu Ala Gln Thr Leu Phe Ile Ser Leu Gly Gly Phe Phe Phe 
225                 230                 235                 240 


Ser Ser Cys Ile Pro Glu Arg Phe Tyr Pro Gly Lys Tyr Asp Ile Ile 
                245                 250                 255     


Gly Asn Ser His Gln Leu Phe His Ile Cys Ser Ala Leu Ala Met Tyr 
            260                 265                 270         


Phe Gln Ser Leu Leu Ile Glu Gly His Lys Leu Ile Tyr Leu Leu Val 
        275                 280                 285             


Thr Ile Arg Cys Phe Arg Tyr Ser Arg Asn Asn Leu Ser Val Thr Trp 
    290                 295                 300                 


Ala Cys Thr Val Gly Val Phe Ser Leu Val Phe Val Leu Thr His Thr 
305                 310                 315                 320 


Thr Val Leu Leu His Asp Arg Thr Arg Pro Asn Ile Val Lys Ile Thr 
                325                 330                 335     


Lys Ile Thr 
            


<210>  127
<211>  343
<212>  PRT
<213>  Ciona intestinalis

<400>  127

Met Val Asp Pro Asp Asp Tyr Phe His Ala Leu Lys Asn Ser Cys Asn 
1               5                   10                  15      


Asn Val Pro Gln Cys Cys Val Glu Pro Tyr Ile Leu Lys Gly Tyr Val 
            20                  25                  30          


Leu Pro His Met Pro Leu Arg Tyr Tyr Phe Lys Val Leu Trp Ile Pro 
        35                  40                  45              


Asn Asn Glu Leu Phe Asn Val Trp Thr His Leu Phe Pro Cys Leu Phe 
    50                  55                  60                  


Phe Ile Ser Met Leu Tyr Gln Phe Asn Gln Ser Leu Asn Leu Phe Glu 
65                  70                  75                  80  


Ser Trp Pro Val Leu Ile Val Thr Val Ser Ala Ile Leu Leu Thr Leu 
                85                  90                  95      


Cys Ser Ser Leu Ala His Leu Phe His Ser Arg Ser Ser Phe Gln His 
            100                 105                 110         


Cys Cys Trp Phe Met Val Asp Tyr Phe Gly Ile Thr Thr Phe Ala Tyr 
        115                 120                 125             


Ser Ser Thr Val Ser His Phe Phe Ala Ser Ser Gln Leu Ser Tyr Tyr 
    130                 135                 140                 


Asn Arg Ile Gly Trp Leu Asn Leu Leu Val Phe Thr Leu Ile Ala Cys 
145                 150                 155                 160 


Cys Gly Phe Leu Cys Met Ser Phe Thr Gln Ala Gly Asn Arg Trp Gln 
                165                 170                 175     


Ser Val Glu Asn Ala Arg Lys Met Lys Leu Trp Ser Thr Val Phe Gly 
            180                 185                 190         


Tyr Leu Tyr Gly Met Leu Pro Ile Met His Arg Tyr Leu Ile Asn Ala 
        195                 200                 205             


Glu Asn Asp His Ala Leu Tyr Tyr His Lys Leu Gln Phe Ile Cys Met 
    210                 215                 220                 


Leu Leu Cys Pro Leu Phe Tyr Thr Ser Asp Leu Pro Gln Lys Leu Trp 
225                 230                 235                 240 


Pro Gly Lys Phe Asp Ile Val Gly His Ser His Gln Ile Phe His Val 
                245                 250                 255     


Phe Ala Ala Leu Ser Cys Tyr Phe Glu Ile Val Ala Ile His Met Asp 
            260                 265                 270         


Val Thr Asp Ile Asn Gly Pro Trp Asn Ala Leu Lys His Gln Asn Asp 
        275                 280                 285             


Phe Pro Thr Phe Glu Leu Phe Cys Thr Cys Ala Leu Ala Leu Ile Val 
    290                 295                 300                 


Tyr Cys Ile Ile Leu Ala Ile Tyr Ile Ala Arg Ser Ile His Ala Asp 
305                 310                 315                 320 


Ser Ile Lys Lys Ile Pro Ala Cys Gln Cys Ser Asp Leu Asn Lys Asn 
                325                 330                 335     


His Gln Gln Lys Lys Val Asp 
            340             


<210>  128
<211>  355
<212>  PRT
<213>  Ciona intestinalis

<400>  128

Met Lys Pro Thr Asn Ser Asp Asp Glu Gln Asn Asn Asn Val Leu Lys 
1               5                   10                  15      


Gln Leu Pro Asp Glu Asn Asp Phe Leu His Ala Leu His Asn Asp His 
            20                  25                  30          


Thr Thr Val Pro Gln Cys Thr Val Ala Lys Tyr Ile Val Lys Gly Tyr 
        35                  40                  45              


Val Leu Pro His Met Pro Trp Arg Tyr Tyr Val Lys Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ser Asn Glu Leu Leu Asn Ile Trp Thr His Leu Ile Pro Gly Leu 
65                  70                  75                  80  


Tyr Phe Ile Lys Met Leu Phe Arg Tyr Asn Glu Ala Ile Asp Leu Val 
                85                  90                  95      


Glu Asn Trp Pro Leu Ser Leu Thr Ile Ile Ser Ser Ile Thr Val Met 
            100                 105                 110         


Met Cys Ser Ala Leu Met His Thr Phe His Ser Arg Ser Met Ser Asp 
        115                 120                 125             


His Ala Cys Trp Met Met Leu Asp Phe Phe Gly Ile Val Phe Tyr Ala 
    130                 135                 140                 


Phe Gly Ser Thr Val Ser His Phe Tyr Gly Cys Ser Glu Leu His Tyr 
145                 150                 155                 160 


Tyr Gln Arg Ile Gly Trp Trp Asn Leu Leu Ile Phe Met Phe Asn Cys 
                165                 170                 175     


Thr Ser Val Phe Ala Cys Cys Cys Asn Ser Lys Val Gly Gln Lys Asn 
            180                 185                 190         


Ser Asp Asp His Phe Thr Arg Phe Leu Arg Ile Ala Ser Val Gly Gly 
        195                 200                 205             


Gly Tyr Ile Tyr Gly His Leu Pro Leu Met His Arg Leu Phe Thr Ser 
    210                 215                 220                 


Gly Leu Asp Glu Ala Met Val Tyr His Ile Ile Ser Thr Val Cys Leu 
225                 230                 235                 240 


Thr Ile Ala Val Val Val Tyr Leu Ser Asp Phe Pro Gln Arg Trp Phe 
                245                 250                 255     


Ser Gly Thr Phe Asp Ile Ile Gly Gln Ser His Gln Leu Phe His Val 
            260                 265                 270         


Leu Ser Ala Leu Cys Cys Tyr Phe Asp Ile Leu Ala Val Glu Gln Asp 
        275                 280                 285             


Met Arg Ala Ser Asp Arg His Trp Ser Val Leu Ser Val Gln Pro Asp 
    290                 295                 300                 


Thr Pro Ser Leu Leu His Val Ser Thr Ala Ala Ile Leu Leu Ile Ile 
305                 310                 315                 320 


Phe Ser Tyr Lys Phe Ala Ser Arg Cys Leu Gln Ser His Gly Gln Arg 
                325                 330                 335     


Ile Gly Ile Cys Pro Cys Leu Cys Cys Lys Gln Thr Asp Pro Lys Met 
            340                 345                 350         


Lys Tyr Gln 
        355 


<210>  129
<211>  340
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  129

Met Trp Thr Ile Lys Leu Leu Arg Phe Asn Gln Val Pro Ser Asp Phe 
1               5                   10                  15      


His Glu Pro Phe Ile Ile Ser Gly Tyr Arg Ser Cys Arg Ser Ser Ile 
            20                  25                  30          


Ser Ser Cys Leu Val Ser Ala Ile Gln Gly Ser Asn Glu Thr Ile Asn 
        35                  40                  45              


Phe Trp Thr His Phe Ile Pro Ala Met Trp Phe Gly Trp Thr Thr Leu 
    50                  55                  60                  


Gln Gln Val Ala Asp Gly Ala Phe Ile Gln Asp Pro Phe Ser Trp Pro 
65                  70                  75                  80  


Leu Ile Cys Phe Leu Leu Ser Cys Val Met Tyr Leu Phe Ala Ser Ala 
                85                  90                  95      


Met Ala His Leu Phe Asn Cys Ile Ser Leu Pro Ala Arg Tyr Val Thr 
            100                 105                 110         


Phe Phe Phe Asp Tyr Gly Ala Ile Ser Ile Tyr Ser Phe Gly Ser Ser 
        115                 120                 125             


Ile Ala Tyr Cys Ala Tyr Thr Phe Pro Pro Glu Leu Leu His Thr Pro 
    130                 135                 140                 


Leu His Gln Val Phe Leu Val Met Ala Met Phe Thr Ala Met Leu Ser 
145                 150                 155                 160 


Thr Phe Leu Ala Cys Tyr Ser Arg Phe Ser Ser Asn His Phe Leu Cys 
                165                 170                 175     


His Ser Gly Arg Leu Pro Ala Ile Met Ile Pro Tyr Phe Trp Cys Ser 
            180                 185                 190         


Leu Pro Leu Leu Tyr Arg Val Ile Phe Cys Val Glu Pro Asp Pro Asn 
        195                 200                 205             


Ser Asp Ala Ala Leu Phe His Val Arg Gln Phe Phe Cys Thr Ala Val 
    210                 215                 220                 


Thr Val Phe Phe Tyr Ala Ser Arg Phe Pro Glu Val Leu Ala Pro Gly 
225                 230                 235                 240 


Ile Phe Asp Phe Ile Gly His Ser His Gln Leu Phe His Ile Gly Gly 
                245                 250                 255     


Ala Phe Ser Thr Tyr Trp Gln Tyr His Ala Leu Leu Leu Asp Lys Ala 
            260                 265                 270         


Glu Arg Arg Gln Phe Leu Val Glu Ala Val Gly Leu Pro Thr Val Ala 
        275                 280                 285             


Gly Thr Ala Gly Ala Phe Val Val Val Leu Thr Val Asn Leu Leu Ile 
    290                 295                 300                 


Ile Trp Gly Phe Ser His Trp Val Ser Gln Pro Lys Ser Leu Glu Met 
305                 310                 315                 320 


Val Arg Gln Arg Leu Glu Glu Asp Lys Arg Glu Lys Lys Gly Cys Gly 
                325                 330                 335     


Cys Lys Cys Asp 
            340 


<210>  130
<211>  368
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  130

Met Ala Glu Arg Gly Ala Met Ser Ser Thr Lys Gly Asn Ala Thr Asp 
1               5                   10                  15      


Asp Asp Arg Tyr Pro Thr Gly Thr Lys Gln His Ser Pro Arg Gln Ser 
            20                  25                  30          


Ser Ala Lys Ser Ser Gly Lys Cys Pro His Ser His Phe Leu Met Cys 
        35                  40                  45              


Ala Leu Thr Ala Gly Gln Val Pro Ser Asp Phe Arg Glu Pro Phe Ile 
    50                  55                  60                  


Leu Ser Gly Tyr Arg Ser Tyr Arg Ser Ser Ala Ser Ser Cys Leu Ala 
65                  70                  75                  80  


Ser Ala Leu Gln Arg Thr Asn Glu Thr Val Asn Phe Trp Thr His Phe 
                85                  90                  95      


Ile Pro Ala Leu Ile Phe Ala Arg Leu Thr Trp Phe Val Ala Val Thr 
            100                 105                 110         


Asp His Gly Leu Ala Leu Asp Pro Phe Thr Trp Pro Val Ile Val Phe 
        115                 120                 125             


Leu Leu Gly Ala Cys Phe Tyr Met Thr Ala Ser Ser Val Ala His Met 
    130                 135                 140                 


Phe Asn Ser Met Ser Gln Cys Ala Arg Tyr Ile Phe Phe Phe Ile Asp 
145                 150                 155                 160 


Tyr Cys Gly Val Ser Leu Tyr Ser Leu Gly Thr Cys Ile Ala Tyr Tyr 
                165                 170                 175     


Ala Tyr Ala Phe Pro Pro Glu Leu Leu Asp Thr Pro Leu Tyr His Ala 
            180                 185                 190         


Tyr Leu Pro Val Ala Met Val Thr Ala Leu Cys Ser Thr Tyr Leu Ala 
        195                 200                 205             


Cys Cys Ser Arg Phe Ser Ser Trp Pro Pro Phe Arg Asp Ala Gly Arg 
    210                 215                 220                 


Leu Pro Ala Phe Ala Ile Pro Tyr Ile Trp Cys Asn Val Pro Leu Val 
225                 230                 235                 240 


Tyr Arg Val Ile Tyr Cys Glu Ser Thr Gly Cys Gly Ser Glu Ala Leu 
                245                 250                 255     


Phe Phe His Ile Gln Gln Phe Tyr Trp Val Leu Gly Phe Ala Phe Phe 
            260                 265                 270         


Tyr Ala Thr Arg Val Pro Glu Val Ile Ala Pro Gly Thr Phe Asp Ile 
        275                 280                 285             


Ile Gly His Ser His Gln Phe Phe His Ile Gly Ser Ser Ile Ala Ser 
    290                 295                 300                 


Tyr Cys Gln Tyr Leu Ala Leu Ile Ala Glu Leu Thr Glu Arg Ala His 
305                 310                 315                 320 


Tyr Leu Asp Asp Leu Arg Arg Pro Thr Phe Val Thr Thr Phe Gly Val 
                325                 330                 335     


Leu Leu Thr Val Leu Val Gly Asn Leu Val Ile Val Trp Ile Leu Ser 
            340                 345                 350         


Arg Arg Val Ile Gln Met Ser Arg Ser Lys Ala Thr Asn His Lys Asp 
        355                 360                 365             


<210>  131
<211>  344
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  131

Met Gln Ile Asp Val Leu Ala Lys Asp Val Ile Leu Leu Cys Trp Asp 
1               5                   10                  15      


Leu Asn Pro Val Pro Leu Ser Tyr Arg Glu Pro Phe Ile Leu Ser Arg 
            20                  25                  30          


Tyr Arg Ser Cys Arg Ser Ser Leu Gly Thr Cys Leu Leu Ser Ala Leu 
        35                  40                  45              


His Ala Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Val Pro Phe 
    50                  55                  60                  


Leu Val Leu Gly Leu Val Thr Leu Gln His Val Leu Asp Pro Ser Phe 
65                  70                  75                  80  


Arg Ser Asp Pro Phe Asn Trp Ala Phe Leu Val Phe Ala Leu Ser Gly 
                85                  90                  95      


Cys Val Tyr Leu Leu Gly Ser Ser Ile Ala His Met Phe Ser Cys Tyr 
            100                 105                 110         


Ser Glu Val Ala His Tyr Ile Cys Tyr Phe Ile Asp Tyr Ser Thr Val 
        115                 120                 125             


Ser Ile Tyr Ile Val Gly Leu Cys Val Ala Tyr Asn Glu Tyr Val Phe 
    130                 135                 140                 


Pro Arg Tyr Ala Ile Asn Thr Val Met His Arg Val Tyr Leu Pro Met 
145                 150                 155                 160 


Val Phe Leu Leu Ser Leu Leu Phe Ser Ala Thr Ser Cys Ala Thr Lys 
                165                 170                 175     


Tyr Ser Lys His His Leu Leu Arg Ile His Gly Arg Lys Val Thr Phe 
            180                 185                 190         


Pro Ala Tyr Phe Leu Trp Cys Asn Leu Pro Leu Ala Tyr Arg Ala Phe 
        195                 200                 205             


Phe Gly Ser Ser Ser Ser Ser Ser Ser Ser Thr Ala Asp Val Tyr His 
    210                 215                 220                 


Ile Ala His Thr Ile Ala Ala Thr Leu Ala Gly Leu Ser Tyr Ala Ser 
225                 230                 235                 240 


His Leu Pro Glu Ala Leu Ala Pro Gly Arg Phe Asp Phe Ile Ala Gln 
                245                 250                 255     


Ser His Gln Leu Phe His Leu Cys Thr Ala Val Leu Thr Tyr Tyr Gln 
            260                 265                 270         


Tyr His Ala Leu Ser Ala Glu Met His Asp Arg Arg Glu Glu Leu Leu 
        275                 280                 285             


Thr Leu Cys Gly Thr Pro Thr Phe Val Gly Thr Phe Gly Val Leu Leu 
    290                 295                 300                 


Ala Asn Ile Phe Leu His Gly Val Leu Ile Ala Gly Leu Ala Ile Trp 
305                 310                 315                 320 


Leu Arg Lys Pro Gly Gln Leu Ala Lys Ile His Lys Ser Leu Glu Met 
                325                 330                 335     


Pro Thr Ile Ser His Lys Glu Asp 
            340                 


<210>  132
<211>  345
<212>  PRT
<213>  Strongylocentrotus purpuratus

<400>  132

Met Trp Glu Asn Val Asn Phe Arg Arg Leu Leu Gly Gly Ala Ser Lys 
1               5                   10                  15      


Asn Gly Tyr Arg Gly Ser Ala Asp Phe Asp Thr Arg Asp Val Asp Glu 
            20                  25                  30          


Val Pro Val Ile Phe Gln Glu Pro Phe Val Lys Tyr Gly Tyr Arg Glu 
        35                  40                  45              


Pro His His Gly Leu Thr Tyr Tyr Ala Lys Ser Phe Leu Glu Leu His 
    50                  55                  60                  


Asn Glu Ser Leu Asn Val Trp Thr His Ala Ala Ala Phe Ser Ile Leu 
65                  70                  75                  80  


Leu Tyr Gln Ser Tyr Gln Phe Cys Ser Pro Leu Asp Val Met Asn Asp 
                85                  90                  95      


Pro Tyr Ala Leu Ile Phe Ala Ile Phe Cys Ala Cys Cys Cys Thr Phe 
            100                 105                 110         


Leu Leu Leu Ser Ala Ile Ala His Leu Phe His Ser His Ser Glu Leu 
        115                 120                 125             


Thr His Tyr Thr Cys Trp Phe Ile Asp Tyr Leu Gly Met Ser Ile Tyr 
    130                 135                 140                 


Gly Phe Gly Gly Ser Leu Ala His Tyr Tyr Phe Ser Ala Leu Pro Ser 
145                 150                 155                 160 


Phe Met His Ser Val Ser Trp Phe Phe Ile Pro Leu Leu Leu Val Leu 
                165                 170                 175     


Ser Tyr Gly Val Cys Phe Cys Cys Ser Phe Ala Lys Tyr Arg Tyr Lys 
            180                 185                 190         


Arg Pro Tyr Pro Phe Ala Arg Lys Leu Trp Gln Leu Gly Ser Val Gly 
        195                 200                 205             


Ala Gly Tyr Val Leu Ile Ile Thr Pro Ile Tyr His Arg Leu Leu Gly 
    210                 215                 220                 


Cys Leu Phe Ser Asp Gln Pro Met Asp Gln Ala Leu Phe Phe His Phe 
225                 230                 235                 240 


Leu Gln Val Ser Phe Ile Leu Pro Ser Ile Phe Phe Phe Ala Ala Pro 
                245                 250                 255     


Tyr Pro Gln Lys Leu Gln Pro Gly Lys Tyr Asp Ile Val Gly His Gly 
            260                 265                 270         


His Gln Met Phe His Val Ala Met Ala Phe Val Ser Tyr Tyr Gln Met 
        275                 280                 285             


Lys Ala Val His Leu Asp Phe Leu His Arg Arg Asp Glu Tyr Ser Thr 
    290                 295                 300                 


His Thr Asp Pro Ser Met Ile Gln Ala Ile Leu Tyr Ile Thr Val Leu 
305                 310                 315                 320 


Val Ile Ala Asp Ile Ile Thr Leu Phe Val Phe Arg His Lys Val Trp 
                325                 330                 335     


Gln Asn Ile Ser Lys Val Asp Met Asp 
            340                 345 


<210>  133
<211>  357
<212>  PRT
<213>  Schistosoma japonicum

<400>  133

Met Lys Leu Val Phe Asn Gln Ser Phe Thr Gly Ser Asp Lys Asn Val 
1               5                   10                  15      


Gly Cys Arg Ala Pro Trp Ser Leu Gln Pro Ser Arg Lys Ser Arg Lys 
            20                  25                  30          


Asp Lys Leu Glu Ile Leu Leu Ala Ser Gln Ile Ser Ser Asp Phe His 
        35                  40                  45              


Glu Ile Gly Ile Leu Ser Gly Tyr Arg Lys Pro Ser Ala Ser Leu Ala 
    50                  55                  60                  


Ala Gly Ile Leu Ser Ile Phe Gln Leu His Asn Glu Thr Leu Asn Ile 
65                  70                  75                  80  


Trp Thr Gln Ile Ile Pro Thr Val Tyr Phe Val Ile Glu Leu Ile Leu 
                85                  90                  95      


Asn Phe Phe His Ala Gly Glu Arg Phe Leu Leu Ile Tyr Leu Val Thr 
            100                 105                 110         


Ala Val Thr Phe Leu Phe Thr Ser Ser Cys Ala His Thr Leu Ser Cys 
        115                 120                 125             


Leu Ser Pro Arg Ala Arg His Val Cys Phe Phe Leu Asp Tyr Ile Gly 
    130                 135                 140                 


Ile Thr Leu Tyr Ser Cys Gly Cys Ala Val Cys Tyr Tyr Ala Phe Ala 
145                 150                 155                 160 


Leu Pro Leu Asp Phe Leu Ser Leu Ser Pro Val Phe Tyr Leu Asn Leu 
                165                 170                 175     


Cys Asp Leu Phe Leu Phe Ile Ser Val Met Phe Cys Ile Cys Gly Ala 
            180                 185                 190         


Tyr Leu Ser Cys Gln Thr Arg Phe Trp Lys Pro Ser Leu Leu Arg Asn 
        195                 200                 205             


Val Val Arg Met Gly Ala Phe Ser Ile Asn Leu Leu Tyr Leu Ala Thr 
    210                 215                 220                 


Pro Ile Leu Trp Arg Ser Tyr Ile Cys Arg Tyr Met Glu Arg Asp Tyr 
225                 230                 235                 240 


Asp Thr Tyr Glu Cys Cys Ser Leu Tyr Tyr Trp Asn Leu His Phe Met 
                245                 250                 255     


Ser Ala Phe Ala Ala Gly Leu Leu Tyr Val Ser His Phe Pro Glu Arg 
            260                 265                 270         


Leu Phe Leu Gly Lys Phe Asp Phe Phe Gly His Ser His Gln Ile Phe 
        275                 280                 285             


His Ile Leu Ser Ala Phe Gly Ser Val Thr Gln Tyr Tyr Ala Leu Arg 
    290                 295                 300                 


Thr Asp Leu Lys Glu Arg Ser Ala Lys Leu Lys Leu Val Leu His Ala 
305                 310                 315                 320 


Pro Ser Ile Pro Phe Ser Leu Leu Cys Leu Cys Leu Val Ile Leu Cys 
                325                 330                 335     


Asp Leu Ile Ile Phe Leu Lys Phe Tyr Lys Arg Leu Cys Ile Ile Ile 
            340                 345                 350         


Arg Ser Lys Arg Leu 
        355         


<210>  134
<211>  340
<212>  PRT
<213>  Branchiostoma floridae

<400>  134

Met Trp Ser Gly Leu Lys Val Trp Thr Thr Glu Leu Leu His Ile Asp 
1               5                   10                  15      


Asp Ile Pro His His Tyr Arg Glu His Cys Ile Val Arg Gly Tyr Arg 
            20                  25                  30          


Lys Pro Lys Ser Ser Ala Thr Asp Cys Val Leu Ser Val Phe Gln Leu 
        35                  40                  45              


Thr Asn Glu Thr Leu Asn Phe Trp Thr His Phe Leu Pro Phe Trp Tyr 
    50                  55                  60                  


Phe Ile Trp Arg Leu Val Ala Val Ser Tyr Asp Phe Asp Phe Trp Val 
65                  70                  75                  80  


Asp Pro Tyr Thr Trp Pro Leu Leu Val Phe Met Leu Ser Cys Cys Ala 
                85                  90                  95      


Tyr Pro Ile Thr Ser Ser Met Ala His Cys Phe Asn Cys Met Ser Asp 
            100                 105                 110         


Arg Ala Gln His Ile Ser Tyr Phe Met Asp Tyr Gly Ala Leu Ser Leu 
        115                 120                 125             


Tyr Ser Leu Gly Ser Gly Ile Ala Tyr His Ala Tyr Val Phe Pro Asp 
    130                 135                 140                 


Ser Phe Ile Gly Ser Trp Phe Asp Asp Val Phe Leu Arg Val Ala Thr 
145                 150                 155                 160 


Phe Leu Ala Val Gly Cys Thr Leu Leu Ser Cys Met Ser Arg Phe Glu 
                165                 170                 175     


Asp Arg Pro Arg Ile Arg Lys Ala Leu Arg Leu Leu Ser Phe Ser Leu 
            180                 185                 190         


Pro Tyr Phe Phe Asn Ser Val Pro Leu Cys Tyr Arg Val Phe Leu Cys 
        195                 200                 205             


His Gly Glu Gly Cys Ser His Asn Glu Ala Val Ile Ile Tyr Tyr Trp 
    210                 215                 220                 


Met Leu Phe Phe Ser Phe Leu Thr Pro Phe Leu Tyr Ala Thr His Ile 
225                 230                 235                 240 


Pro Glu Val Leu Ala Pro Gly Lys Phe Asp Leu Ile Gly His Ser His 
                245                 250                 255     


Gln Leu Phe His Val Thr Gly Ile Ile Ala Thr Asn Phe Gln Ile Ser 
            260                 265                 270         


Gly Val Leu Thr Asp Leu Gln Met Arg Arg Glu Phe Leu Asp Val Val 
        275                 280                 285             


Arg Pro Gln Pro Met Glu Phe Trp Asp Asn Ile Gly Leu Met Ser Leu 
    290                 295                 300                 


Val Leu Met Lys Asn Leu Leu Ile Ile Leu Phe Phe Thr Leu Ser Leu 
305                 310                 315                 320 


Tyr Val Glu Lys Pro Thr Trp Leu Lys Val Arg Gly His Gly Ile Lys 
                325                 330                 335     


Gly Lys Val Asp 
            340 


<210>  135
<211>  323
<212>  PRT
<213>  Branchiostoma floridae

<400>  135

Met Gln Leu Pro Arg Met Pro Cys Thr Lys Arg Ser Glu Asp Val Pro 
1               5                   10                  15      


Val Leu Phe Arg Glu Pro Tyr Val His Asp Gly Tyr Arg Pro Pro His 
            20                  25                  30          


Gln Pro Trp His Tyr Tyr Leu Leu Ser Leu Phe Gln Ile His Asn Glu 
        35                  40                  45              


Val Met Asn Ala Trp Thr His Leu Ile Pro Phe Ser Ile Leu Leu Tyr 
    50                  55                  60                  


Asn Val Phe Thr Arg Thr Gly Glu Leu Asp Phe Ser Ala Asp His Thr 
65                  70                  75                  80  


Ser Trp Ala Leu Leu Leu Leu Gly Phe Gly Gly Cys Ser Phe Leu Phe 
                85                  90                  95      


Leu Ser Phe Ala Ala His Leu Phe Gln Ser His Ser Glu His Ala His 
            100                 105                 110         


Tyr Met Cys Phe Ile Leu Asp Tyr Val Gly Ile Ala Phe Tyr Gly Phe 
        115                 120                 125             


Thr Ala Gly Leu Ala Gln Phe Ser Ile Cys Ser Asp Pro Trp Phe Ser 
    130                 135                 140                 


Arg Val Phe Lys Pro Val Phe Phe Pro Leu Leu Val Val Ser Gly Cys 
145                 150                 155                 160 


Tyr Thr Cys Ile Cys Cys Ser Tyr Gly Lys Val Arg Phe Asn Arg Pro 
                165                 170                 175     


Tyr Pro Pro Met Arg Trp Val Leu Gln Ile Ser Ala Ile Gly Ser Met 
            180                 185                 190         


Tyr Val Leu Ser Met Ser Pro Val Leu His Arg Val Met Met Asp His 
        195                 200                 205             


Ala Arg Asn Ser Met Asp Thr Val Ser Trp Met His Val Ala His Thr 
    210                 215                 220                 


Ala Phe Phe Met Thr Gly Val Phe Phe Tyr Thr Ser Asn Val Pro His 
225                 230                 235                 240 


Arg Phe Gln Pro Gly Met Phe Asp Ile Val Gly His Gly His Gln Leu 
                245                 250                 255     


Phe His Val Ala Met Ala Thr Met Ala Ile Ile Gln Phe Glu Thr Val 
            260                 265                 270         


Phe Arg Asp Leu Gln Ser Gly Arg His Phe Leu Leu Ser Arg Pro Ser 
        275                 280                 285             


Val Thr Ser Ile Thr Val Gln Ala Thr Val Val Leu Leu Cys Cys Val 
    290                 295                 300                 


Val Ser Thr Leu Ala Met Ala Ala Lys Val Arg Arg Lys Leu Lys Asn 
305                 310                 315                 320 


Lys Val Gln 
            


<210>  136
<211>  315
<212>  PRT
<213>  Branchiostoma floridae

<400>  136

Met Pro Asp Met Lys Arg Ser Leu Thr Ile Asp Glu Val Pro Glu Val 
1               5                   10                  15      


His Lys Glu Pro Tyr Val Leu Thr Gly Tyr Arg Pro Pro Gln Gln Pro 
            20                  25                  30          


Trp Arg Phe Tyr Leu Met Ser Ile Phe Ser Lys Asn Asn Glu Thr Met 
        35                  40                  45              


Asn Val Trp Thr His Leu Leu Pro Cys Phe Tyr Val Leu Trp Leu Leu 
    50                  55                  60                  


Lys Thr Tyr Ser Asp Glu Ala Gly Phe Thr Thr Ser Asp Pro Ser Ser 
65                  70                  75                  80  


Met Leu Leu Leu Leu Phe Gly Thr Ser Asn Phe Ala Phe His Leu Phe 
                85                  90                  95      


Ser Ala Phe Ala His Leu Leu His Ser Arg Ser Val Ala Val Tyr Tyr 
            100                 105                 110         


Val Ile Phe Ile Phe Asp Tyr Leu Gly Ile Ala Phe His Ala Phe Thr 
        115                 120                 125             


Ser Gly Thr Val Gln Tyr Phe Leu Ser Ser Glu Thr Ser Phe Phe His 
    130                 135                 140                 


Ala Val His Pro Trp Tyr Pro Trp Ala Cys Val Leu Phe Thr Cys Cys 
145                 150                 155                 160 


Tyr Phe Ala Ala Asn Ala Tyr Ser His Val Thr Tyr Arg Arg Cys His 
                165                 170                 175     


Ser Glu Arg Ala Leu Thr Gln Val Val Ser Phe Ser Thr Thr Tyr Leu 
            180                 185                 190         


Trp Val Thr Leu Pro Val Ile His Arg Ile Tyr Ser Asp Ile Tyr Asn 
        195                 200                 205             


Gly Thr Val Asp Asp Val Thr Trp Met His Val Asn His Ile Leu Leu 
    210                 215                 220                 


Met Ile Ile Ala Gly Phe Phe Phe Gly Ser Glu Met Pro Gln Arg Phe 
225                 230                 235                 240 


Phe Pro Gly Ala Cys Asp Val Ile Gly His Gly His Gln Ile Phe His 
                245                 250                 255     


Val Ile Ile Thr Ala Ser Val Met Val Gln Leu Glu Ala Ser Phe Ala 
            260                 265                 270         


Asp Leu Gln Asn Arg Arg His Leu Asp Leu Val Arg Ile Arg Pro Thr 
        275                 280                 285             


Asp Met Ser Ile Thr Ala Tyr Leu Val Val Leu Phe Thr Ser Tyr Gly 
    290                 295                 300                 


Tyr Ile Thr Val Ile Phe Val Arg Lys Ala Leu 
305                 310                 315 


<210>  137
<211>  320
<212>  PRT
<213>  Branchiostoma floridae

<400>  137

Met Pro Asp Met Lys Arg Ser Leu Thr Ile Asp Glu Val Pro Asp Val 
1               5                   10                  15      


His Lys Glu Pro Tyr Val Leu Thr Gly Tyr Arg Pro Pro Gln Gln Pro 
            20                  25                  30          


Trp Arg Phe Tyr Leu Met Ser Ile Phe Ser Gln His Asn Glu Thr Met 
        35                  40                  45              


Asn Val Trp Thr His Leu Leu Pro Cys Phe Tyr Val Leu Trp Leu Leu 
    50                  55                  60                  


Lys Thr Tyr Ser Asp Asp Val Ser Phe Ala Ser Asp Asp Asp Ser Ser 
65                  70                  75                  80  


Met Leu Leu Leu Leu Phe Gly Thr Ser Asn Phe Thr Phe His Ile Phe 
                85                  90                  95      


Ser Ala Cys Ala His Leu Leu His Ser Arg Ser Val Ala Val Tyr Tyr 
            100                 105                 110         


Val Thr Phe Ile Phe Asp Tyr Leu Gly Ile Ala Phe His Ala Phe Thr 
        115                 120                 125             


Ser Gly Thr Val Gln Tyr Phe Leu Ser Ser Lys Ala Ser Phe Phe His 
    130                 135                 140                 


Ala Val His Pro Trp Phe Pro Trp Ala Cys Val Leu Phe Ser Cys Cys 
145                 150                 155                 160 


Tyr Phe Ala Ala Asn Ala Tyr Ser His Val Thr Tyr Arg Arg Cys His 
                165                 170                 175     


Ser Glu Arg Ala Leu Thr Gln Val Val Ser Phe Ser Thr Thr Tyr Leu 
            180                 185                 190         


Trp Ala Val Ser Pro Val Ile His Arg Ile Tyr Ser Asp Ile Tyr Asn 
        195                 200                 205             


Gly Thr Ala Asp Asp Val Thr Trp Met His Val Asn His Ile Leu Leu 
    210                 215                 220                 


Met Ile Ile Ala Gly Phe Phe Phe Gly Ser Glu Ile Pro Gln Arg Phe 
225                 230                 235                 240 


Phe Pro Gly Ala Cys Asp Val Ile Gly His Gly His Gln Ile Phe His 
                245                 250                 255     


Val Ile Ile Thr Ala Ser Val Met Val Gln Leu Glu Ala Ser Phe Ala 
            260                 265                 270         


Asp Leu Gln Asn Arg Arg His Leu Asp Leu Val Arg Ile Arg Pro Thr 
        275                 280                 285             


Asp Met Ser Ile Thr Ala Tyr Leu Val Val Leu Leu Ser Tyr Gly Tyr 
    290                 295                 300                 


Ile Thr Ala Ile Phe Val Arg Lys Ala Leu Ser Lys Ala Asn His Ile 
305                 310                 315                 320 


<210>  138
<211>  320
<212>  PRT
<213>  Branchiostoma floridae

<400>  138

Met Pro Asp Met Lys Arg Ser Leu Thr Ile Asp Glu Val Pro Asp Val 
1               5                   10                  15      


His Lys Glu Pro Tyr Val Leu Thr Gly Tyr Arg Pro Pro Gln Gln Pro 
            20                  25                  30          


Trp Arg Phe Tyr Leu Met Ser Ile Phe Ser Gln His Asn Glu Thr Met 
        35                  40                  45              


Asn Val Trp Thr His Phe Ile Pro Ser Phe Tyr Val Leu Trp Leu Leu 
    50                  55                  60                  


Lys Ile Tyr Ser Glu Asp Val Ser Phe Ala Ser Asp Ala Ser Ser Met 
65                  70                  75                  80  


Leu Leu Leu Leu Phe Gly Thr Ser Ala Phe Thr Ser Gln Phe Leu Ser 
                85                  90                  95      


Ala Cys Ala His Leu Leu His Ser Arg Ser Val Ala Ala Tyr Tyr Val 
            100                 105                 110         


Thr Phe Ile Phe Asp Phe Leu Gly Ile Ala Phe His Val Phe Thr Ser 
        115                 120                 125             


Gly Thr Val Gln Tyr Phe Leu Ser Ser Glu Ala Ser Phe Phe His Ala 
    130                 135                 140                 


Val Tyr Pro Trp Phe Pro Trp Ala Cys Val Leu Phe Ser Cys Cys Tyr 
145                 150                 155                 160 


Phe Ala Ala Thr Ala Tyr Ser His Val Arg Tyr Thr Arg Cys His Ser 
                165                 170                 175     


Glu Arg Val Met Thr Gln Val Val Ser Phe Ser Ile Ile Tyr Leu Gly 
            180                 185                 190         


Val Thr Ser Pro Val Ile His Arg Ile Tyr Ser Asp Ile Tyr Asn Gly 
        195                 200                 205             


Thr Val Asp Asp Val Thr Trp Met His Val Asn His Ile Leu Leu Val 
    210                 215                 220                 


Ala Ile Ala Gly Phe Phe His Gly Ser Gly Ile Pro Gln Lys Phe Phe 
225                 230                 235                 240 


Pro Gly Ala Cys Asp Val Ile Gly His Gly His Gln Ile Phe His Val 
                245                 250                 255     


Val Ile Ser Thr Ser Leu Ile Phe Gln Leu Glu Ala Ser Phe Ala Asp 
            260                 265                 270         


Leu Gln Asn Arg Arg His Leu Asp Leu Val Arg Leu Arg Pro Pro Asp 
        275                 280                 285             


Met Ser Ile Thr Ala Tyr Leu Ile Val Leu Phe Thr Ser Tyr Gly Tyr 
    290                 295                 300                 


Ile Thr Val Leu Phe Val Arg Lys Ala Leu Ser Lys Ala Asn His Ile 
305                 310                 315                 320 


<210>  139
<211>  320
<212>  PRT
<213>  Branchiostoma floridae

<400>  139

Met Pro Asp Met Lys Arg Ser Leu Thr Ile Asp Glu Val Pro Asp Val 
1               5                   10                  15      


His Lys Glu Pro Tyr Val Leu Thr Gly Tyr Arg Pro Pro Gln Gln Pro 
            20                  25                  30          


Trp Arg Phe Tyr Leu Met Ser Ile Phe Ser Gln His Asn Glu Thr Val 
        35                  40                  45              


Asn Val Trp Thr His Leu Leu Pro Cys Phe Tyr Val Leu Trp Leu Leu 
    50                  55                  60                  


Lys Thr Tyr Ser Asp Glu Val Ser Phe Ala Ser Asp Ala Ser Ser Thr 
65                  70                  75                  80  


Leu Leu Leu Leu Val Gly Thr Ser Ile Phe Thr Ser Gln Phe Leu Ser 
                85                  90                  95      


Ala Cys Ala His Leu Leu His Ser Arg Ser Val Ala Ala Tyr Tyr Val 
            100                 105                 110         


Thr Phe Ile Phe Asp Phe Leu Gly Ile Ala Phe His Val Phe Thr Ser 
        115                 120                 125             


Gly Thr Val Asn Tyr Phe Leu Ser Ser Glu Ala Ser Phe Phe His Ala 
    130                 135                 140                 


Val Tyr Pro Trp Phe Pro Trp Ala Cys Val Leu Phe Ser Cys Cys Tyr 
145                 150                 155                 160 


Phe Ala Ala Asn Ala Tyr Ser His Val Arg Tyr Thr Arg Cys His Ser 
                165                 170                 175     


Glu Arg Ala Met Ile Gln Val Val Ser Phe Gly Met Thr Tyr Leu Trp 
            180                 185                 190         


Ala Val Ser Pro Val Ile His Arg Ile Tyr Tyr Asp Val Tyr Asn Gly 
        195                 200                 205             


Asn Val Asp Asp Val Thr Trp Met His Val Asn His Ile Leu Leu Val 
    210                 215                 220                 


Ala Ile Ala Gly Phe Phe His Gly Ser Gly Met Pro Gln Lys Phe Phe 
225                 230                 235                 240 


Pro Gly Ala Cys Asp Val Ile Gly His Gly His Gln Ile Phe His Val 
                245                 250                 255     


Val Ile Ser Thr Ser Leu Ile Phe Gln Leu Glu Ala Ser Phe Ala Asp 
            260                 265                 270         


Leu Gln Asn Gly Arg His Leu Asp Leu Ala Arg Ile Arg Pro Thr Asp 
        275                 280                 285             


Met Ser Ile Thr Ala Tyr Leu Val Val Leu Phe Thr Ser Tyr Gly Tyr 
    290                 295                 300                 


Ile Thr Val Ile Phe Val Arg Lys Ala Leu Ser Lys Ala Asn Tyr Ser 
305                 310                 315                 320 


<210>  140
<211>  313
<212>  PRT
<213>  Branchiostoma floridae

<400>  140

Met Arg Arg Phe Leu Thr Val Asp Glu Val Pro Asp Ala His Lys Glu 
1               5                   10                  15      


Pro Phe Val Leu Thr Gly Tyr Arg Pro Pro His Arg Pro Trp Arg Tyr 
            20                  25                  30          


Tyr Leu Met Ser Met Phe Ser Met His Asn Glu Thr Met Ser Val Trp 
        35                  40                  45              


Thr His Leu Ile Pro Ser Ile Tyr Val Leu Tyr Val Leu Lys Thr Tyr 
    50                  55                  60                  


Phe Asp Asp Leu Asp Tyr Thr Gly Asp Val Ser Ala Arg Leu Phe Leu 
65                  70                  75                  80  


Tyr Tyr Gly Thr Ser Asn Phe Thr Leu Gln Phe Leu Ser Ala Cys Ala 
                85                  90                  95      


His Leu Leu Cys Ser Arg Ser Val Ala Ala His His Val Ala Phe Thr 
            100                 105                 110         


Ile Asp Tyr Met Gly Ile Ala Phe Tyr Met Tyr Ser Val Thr Leu Ala 
        115                 120                 125             


Gln Gly Tyr Ile Ser Ser Glu Pro Ser Phe Thr Tyr Ala Val His Pro 
    130                 135                 140                 


Trp Phe Pro Trp Val Ala Leu Leu Ile Asn Cys Leu Tyr Phe Ala Ala 
145                 150                 155                 160 


Asn Ala His Ser His Val Arg Tyr Arg Arg Gly Asp Pro Glu Arg Ala 
                165                 170                 175     


Met Leu Gln Leu Cys Ser Phe Ile Met Met Tyr Leu Phe Gly Thr Leu 
            180                 185                 190         


Pro Ile Ile His Arg Ile Leu Ser Asp Ala Tyr Asn Gly Ser Val Asp 
        195                 200                 205             


Asp Val Thr Trp Met Tyr Val Arg His Ile Leu Leu Leu Ala Thr Gly 
    210                 215                 220                 


Gly Phe Phe His Ala Ser Glu Val Pro Gln Arg Phe Leu Pro Gly Met 
225                 230                 235                 240 


Cys Asp Val Ile Gly His Gly His Gln Ile Phe His Val Leu Gly Ser 
                245                 250                 255     


Val Ser Val Leu Thr Glu Met Lys Ala Val Phe Ala Asp Leu Gln Asn 
            260                 265                 270         


Arg Arg His Leu Asp Pro Ile Leu Pro Thr Asp Leu Ser Val Thr Thr 
        275                 280                 285             


Tyr Phe Ile Val Leu Phe Ala Ser Tyr Val Tyr Ile Ala Tyr Val Phe 
    290                 295                 300                 


Val Arg Lys Ala Leu Ser Gln Gly Ser 
305                 310             


<210>  141
<211>  313
<212>  PRT
<213>  Branchiostoma floridae

<400>  141

Met Arg Arg Phe Leu Thr Val Asp Glu Val Pro Asp Val His Lys Glu 
1               5                   10                  15      


Pro Phe Val Leu Thr Gly Tyr Arg Pro Pro His Arg Pro Trp Arg Tyr 
            20                  25                  30          


Tyr Leu Thr Ser Ile Phe Ser Leu His Asn Glu Thr Val Asn Val Trp 
        35                  40                  45              


Thr Asn Ile Ile Pro Cys Ile Tyr Leu Leu Tyr Leu Arg Ser Ile Tyr 
    50                  55                  60                  


Ser Asp Glu Val Lys Phe Thr Gly Gly Val Ser Ala Arg Leu Phe Leu 
65                  70                  75                  80  


Tyr Ala Ala Ile Ser Asn Phe Thr Leu His Phe Leu Ser Thr Cys Ala 
                85                  90                  95      


His Leu Leu Tyr Ser Arg Ser Val Ala Ala Tyr His Ile Gly Phe Met 
            100                 105                 110         


Phe Asp Phe Met Gly Ile Ala Phe Tyr Leu Phe Ser Phe Thr Leu Ala 
        115                 120                 125             


His Cys Tyr Ile Ser Ser Glu Pro Ser Tyr Ala Tyr Ala Val His Pro 
    130                 135                 140                 


Trp Phe Pro Trp Val Val Leu Leu Leu Asn Cys Leu Tyr Met Val Ala 
145                 150                 155                 160 


Asn Ala His Ala His Phe Glu Tyr Gly Arg Gly Asp Pro Lys Arg Ser 
                165                 170                 175     


Met Ile Gln Leu Cys Ser Phe Ser Met Thr Tyr Leu Phe Gly Thr Leu 
            180                 185                 190         


Pro Ile Ile His Arg Ile Leu Ser Asp Val Tyr Asn Gly Ser Val Asp 
        195                 200                 205             


Asp Val Thr Trp Met His Val Arg His Ile Leu Leu Leu Ala Thr Gly 
    210                 215                 220                 


Gly Phe Phe His Ala Ser Glu Val Pro Gln Arg Phe Leu Pro Gly Met 
225                 230                 235                 240 


Cys Asp Val Ile Gly His Gly His Gln Ile Phe His Val Ile Cys Ser 
                245                 250                 255     


Thr Ser Thr Leu Thr His Leu Lys Ala Ile Phe Ala Asp Leu Lys Ser 
            260                 265                 270         


Gly Arg His Gln Asp Leu Val Arg Pro Thr Glu Leu Ser Ile Thr Thr 
        275                 280                 285             


Cys Tyr Ala Val Leu Phe Ala Ala Tyr Gly Tyr Ile Ala Phe Ile Phe 
    290                 295                 300                 


Ala Arg Lys Ala Leu Ser Gln Gly Lys 
305                 310             


<210>  142
<211>  341
<212>  PRT
<213>  Lottia gigantea

<400>  142

Met Ile Thr Arg His Gln Gly Tyr His Lys Arg Thr Pro Ser Cys Ser 
1               5                   10                  15      


Leu Gly Ile Cys Gly Pro Ile Tyr Ala Val Asp Gln Val Pro Glu Gln 
            20                  25                  30          


Phe His Glu Met Phe Ile Leu His Gly Tyr Arg His Pro Lys Ser Ser 
        35                  40                  45              


Phe Thr Gln Cys Val Leu Ser Leu Phe Asp Ala Thr Asn Glu Thr Leu 
    50                  55                  60                  


Asn Ala Trp Thr His Phe Leu Pro Ala Phe Tyr Phe Ile Trp Val Phe 
65                  70                  75                  80  


Phe Gly Leu Ser Gln Ser Leu Asn Phe Trp Ser Asp Ser Tyr Thr Trp 
                85                  90                  95      


Pro Leu Leu Val Tyr Met Leu Val Cys Cys Val Phe Pro Phe Met Ser 
            100                 105                 110         


Ala Ile Ala His Thr Phe Asn Thr Met Ser Glu Arg Ala Arg His Ile 
        115                 120                 125             


Cys Phe Phe Leu Asp Tyr Thr Ala Leu Ser Leu Leu Ser Leu Gly Val 
    130                 135                 140                 


Ala Ile Ala Tyr Arg Ala Tyr Ala Phe Pro Gln Ala Leu Arg Asn Thr 
145                 150                 155                 160 


Ile Tyr Gly Asp Leu Phe Val Thr Gly Ala Val Ile Asn Ser Leu Leu 
                165                 170                 175     


Cys Val Leu Val Ser Cys Glu Thr Arg Phe Met Lys Pro Ser Gly Leu 
            180                 185                 190         


Arg Lys Val Leu Arg Leu Gly Ser Phe Ala Leu Pro Tyr Val Tyr Asp 
        195                 200                 205             


Ser Ile Pro Ile Val Tyr Arg Leu Leu Phe Cys Ser Lys Thr Glu Cys 
    210                 215                 220                 


Ala Leu Thr Ser His Pro Leu Leu Ala Arg Gln Phe Ile Phe Ala Phe 
225                 230                 235                 240 


Phe Ser Ala Phe Leu Tyr Ala Thr His Leu Pro Glu Arg Leu Arg Pro 
                245                 250                 255     


Gly Gln Phe Asp Ile Ile Gly His Ser His Gln Leu Phe His Ile Ser 
            260                 265                 270         


Ser Ile Leu Ala Thr Met Asp Gln Ile Gln Ala Met Leu Gly Asp Met 
        275                 280                 285             


Arg Glu Arg Ala Glu Glu Leu Lys Ala Ser Trp Glu Phe Thr Ser Pro 
    290                 295                 300                 


Asn Ser Ser Leu Asn Ile Leu Ala Ala Val Leu Ile Leu Asn Thr Ile 
305                 310                 315                 320 


Ile Ile Phe Ile Phe Ser Ile Arg Arg Leu Pro Leu Ala Thr Lys Ser 
                325                 330                 335     


Glu Gly Arg Cys Cys 
            340     


<210>  143
<211>  328
<212>  PRT
<213>  Lottia gigantea

<400>  143

Met Ala Thr Lys Ser His Tyr Gln Thr Leu Thr Leu Asn His Ile Pro 
1               5                   10                  15      


Tyr Pro Met Arg His Ala Phe Ile Glu Thr Gly Tyr Arg Gln Leu His 
            20                  25                  30          


Lys Pro Trp Ser Tyr Tyr Tyr Leu Ser Val Ala Lys Trp His Asn Glu 
        35                  40                  45              


Thr Leu Asn Val Trp Thr His Val Ile Ala Ser Ile Ile Ile Pro Tyr 
    50                  55                  60                  


Tyr Gly Val Gln Phe His Gln Lys His Asp Leu Leu Tyr Ser Ser Glu 
65                  70                  75                  80  


Gly Asn Lys Met Leu Val Cys Phe Leu Gly Cys Leu Thr Leu Thr Val 
                85                  90                  95      


Leu Ser Ser Ile Ala His Trp Phe Gly Ser Arg Ser Val Lys Ser His 
            100                 105                 110         


Val Ile Phe Phe Leu Met Asp Tyr Ser Gly Ile Ala Leu Tyr Val Tyr 
        115                 120                 125             


Thr Thr Ser Val Val Ala Leu Tyr Ile Cys Gly Asp Ile His Ser Phe 
    130                 135                 140                 


Glu Thr Leu Arg Pro Phe Tyr Val Gln Val Gly Val Val Leu Ala Thr 
145                 150                 155                 160 


Ile Cys Phe Ala Ile Asn Cys Ala Ala Lys Val Trp Ile Glu Asn Lys 
                165                 170                 175     


Ser Phe Ser Ser Met Lys Lys Phe Gly Met Ile Ala Pro Tyr Ile Leu 
            180                 185                 190         


Phe Ala Leu Tyr Val Ser Cys Pro Leu Phe Pro Arg Tyr Trp His Cys 
        195                 200                 205             


Tyr Leu Asp Ser Lys Cys Ala Leu Tyr Ser Leu Asn Asn Ile Thr Leu 
    210                 215                 220                 


Cys Tyr Ala Leu Phe Val Leu Glu Ala Ile Val Tyr Ala Leu His Ile 
225                 230                 235                 240 


Pro Glu Arg Trp Lys Ala Lys Ser Phe Asp His Cys Gly Gln Ser His 
                245                 250                 255     


Gln Ile Phe His Ile Ser Val Leu Val Thr Met Val Val Gln Ile Tyr 
            260                 265                 270         


Thr Leu Asp Asn Glu Ile Ala Ser Gly His Ser Ser Gln Phe Glu Phe 
        275                 280                 285             


Asp Phe Glu Lys Asn Val Ala Gly Phe Val Cys Leu Val Ile Ser Leu 
    290                 295                 300                 


Thr Met Val Ile Leu Phe Tyr Leu Pro Ser Ile Asp Lys Leu Ser His 
305                 310                 315                 320 


Lys Phe Lys Ser Ser Lys Ser Glu 
                325             


<210>  144
<211>  336
<212>  PRT
<213>  Lottia gigantea

<400>  144

Met Ser Leu Val Ser Ser Thr Ile Gly Leu Ile Lys His Tyr Leu Cys 
1               5                   10                  15      


Ile Gln Lys Thr Val Asn Ser Lys Ser Ile Pro Ala Pro Phe Arg Glu 
            20                  25                  30          


Pro Tyr Ile Leu Thr Gly Tyr Arg Leu Pro Lys Lys Ser Trp Ser Tyr 
        35                  40                  45              


Tyr Ile Val Ser Leu Phe Gln Trp His Asn Glu Thr Ile Asn Val Trp 
    50                  55                  60                  


Thr His Leu Val Ala Cys Leu Phe Val Leu Gly Glu Leu Ala Arg Phe 
65                  70                  75                  80  


Gly Leu Lys Tyr Asp Leu Phe Ser Asp Lys Asp Gly Gly Ala Leu Leu 
                85                  90                  95      


Ala Phe Gly Leu Ser Cys Leu Thr Met Phe Phe Phe Ser Ser Met Ser 
            100                 105                 110         


His Leu Leu His Leu Lys Ser Ile Lys Val His Tyr Ile Leu Ser Leu 
        115                 120                 125             


Ala Asp Tyr Ala Gly Ile Ser Leu Tyr Gly Ser Gly Ala Gly Ile Ala 
    130                 135                 140                 


Thr Phe Tyr Ser Cys Cys Gln Pro Asn Val Tyr Asp Val Met Ala Pro 
145                 150                 155                 160 


Phe Tyr Ile Ile Gly Asn Val Ile Val Gly Trp Phe Val Tyr Ala Thr 
                165                 170                 175     


Cys Val Ile Ala Lys Leu Thr Phe Val Gly Pro His Ala Ala Gln Arg 
            180                 185                 190         


Lys Leu Met Cys Val Phe Ala Phe Thr Ile Gln Gly Thr Trp Ile Val 
        195                 200                 205             


Thr Pro Leu Leu Ser Asn Tyr Tyr Thr Tyr Phe Phe Asp Pro Glu Cys 
    210                 215                 220                 


Ser Ile Trp Asn Leu Asn His Ile Thr Ile Ser Cys Leu Leu Cys Val 
225                 230                 235                 240 


Leu Glu Gly Ile Ala Phe Ala Ala His Ile Pro Glu Arg Tyr Arg Pro 
                245                 250                 255     


Lys Met Phe Asp Tyr Val Gly His Gly His Gln Ile Phe His Leu Leu 
            260                 265                 270         


Cys Ile Phe Ser Val Ile Tyr Gln Met Arg Ala Val Asp Arg Asn Val 
        275                 280                 285             


Asp Met Gly Leu Ala Ala His Thr Gly Met Asn Ile Asn Asp Val Leu 
    290                 295                 300                 


Ile Gly Phe Thr Ala Leu Ile Met Ser Gln Ile Ile Thr Thr Phe Phe 
305                 310                 315                 320 


Val Leu Gly Leu Val Asp Lys Lys Val Asn Glu Ile Val Lys Ala Ser 
                325                 330                 335     


<210>  145
<211>  341
<212>  PRT
<213>  Lottia gigantea

<400>  145

Met Pro Ile Gln Lys Ile Val Lys Ser Phe Pro Ser Thr Thr Ser Lys 
1               5                   10                  15      


Asp Gln Val Pro Lys Leu Phe His Glu Pro His Val Glu Thr Gly Phe 
            20                  25                  30          


Arg His Leu His Gln Pro Trp Ser Tyr Tyr Phe Phe Ser Val Phe Gln 
        35                  40                  45              


Val His Asn Glu Cys Met Asn Thr Trp Thr His Leu Ile Ala Leu Trp 
    50                  55                  60                  


Leu Ile Leu Tyr Arg Thr Tyr Arg Leu Ala Leu Glu Phe Asp Phe Ile 
65                  70                  75                  80  


Asn Asp Pro Tyr Met Trp Pro Leu Leu Ala Ser Leu Leu Thr Met Ile 
                85                  90                  95      


Ile Leu Tyr Ile Cys Ser Ser Cys Ala His Cys Phe Ser Asn Lys Ser 
            100                 105                 110         


Glu Ser Ile His Tyr Thr Cys Phe Met Ile Asp Tyr Ala Gly Ile Gly 
        115                 120                 125             


Leu Tyr Gly Met Gly Ser Thr Met Leu His Tyr Ala Tyr Cys Leu His 
    130                 135                 140                 


Thr Asp Met Val Asp Thr Trp Ala His His Trp Asp Val Glu Leu Gly 
145                 150                 155                 160 


Val Cys Leu Gly Val Leu Val Thr Val Cys Cys Ser Ile Ser Lys Thr 
                165                 170                 175     


Arg Tyr Ser Arg Pro Tyr Pro Phe Val Arg Arg Ile Trp Gln Leu Ser 
            180                 185                 190         


Ser Thr Leu Ala Val Tyr Val Trp Leu Ile Tyr Pro Ile Ala Tyr Arg 
        195                 200                 205             


Val Ala Leu Tyr Leu Phe His His Gln Trp Asp Ser Gly Leu Ser His 
    210                 215                 220                 


His Ile Gln Gln Met Ile Trp Phe Phe Ala Gly Gly Phe Phe Phe Gly 
225                 230                 235                 240 


Ser Asp Val Pro Gln Arg Phe Cys Pro Gly Lys Phe Asp Phe Ile Gly 
                245                 250                 255     


His Ser His Gln Ile Phe His Ile Cys Ile Leu Met Thr Ser Tyr Lys 
            260                 265                 270         


Gln Leu Asp Ala Val Tyr Glu Asp Ile Lys Asn Asn Trp Ala Glu Ile 
        275                 280                 285             


His Arg Leu Pro Glu Pro Thr Leu Ile Asn Ser Phe Gly Ala Val Leu 
    290                 295                 300                 


Leu Thr Ile Val Leu Asn Met Ile Ala Val Met Tyr Phe Arg Ser Val 
305                 310                 315                 320 


Ala Cys Arg Lys Ile His Asp Asn Asn Gln Gln Asn Asn Asn Ile Asn 
                325                 330                 335     


His Asn Lys Thr Asp 
            340     


<210>  146
<211>  340
<212>  PRT
<213>  Lottia gigantea

<400>  146

Met Asp Gly Leu Leu Arg Asn Lys Leu Pro Lys Gln Phe Gln Pro Leu 
1               5                   10                  15      


Phe Lys Ala Gln Arg Thr Gln Phe Gln Glu Lys Val Leu Val Thr Phe 
            20                  25                  30          


Arg Glu Pro Tyr Ile Leu Arg Gly Tyr Arg Leu Thr Asn Lys Pro Trp 
        35                  40                  45              


His Tyr Tyr Leu Val Ser Leu Phe Asn Trp His Asn Glu Thr Ile Asn 
    50                  55                  60                  


Ile Trp Thr His Leu Leu Ser Phe Ile Tyr Ile Val Leu His Ile Ile 
65                  70                  75                  80  


Asn Leu Cys Glu Lys Tyr Asp Val Met Asn Thr Ser Glu Gly Ala Val 
                85                  90                  95      


Val Leu Gly Tyr Ser Phe Gly Ala Leu Ser Leu Thr Ser Phe Ser Thr 
            100                 105                 110         


Ile Ala His Leu Phe His Ser Lys Ser Leu Arg His His Tyr Glu Phe 
        115                 120                 125             


Phe Met Leu Asp Tyr Phe Gly Val Ser Leu Tyr Ser Leu Gly Cys Gly 
    130                 135                 140                 


Ile Leu Thr Ile Tyr Arg Phe Cys Pro Glu Asn Ser Phe Gln Ile Leu 
145                 150                 155                 160 


Gln Thr Phe Tyr Leu Pro Leu His Leu Ile Leu Cys Tyr Asn Asn Phe 
                165                 170                 175     


Leu Ser Ile Ser Thr Ala Lys Leu Tyr Phe Phe Gly Val Ile Arg Lys 
            180                 185                 190         


Cys Leu Thr Val Ser Ala Cys Leu Leu Ser Thr Ile Ser Met Leu Tyr 
        195                 200                 205             


Pro Leu Leu Cys Thr Tyr Tyr Glu Cys Phe Asn Asp Thr Ala Cys His 
    210                 215                 220                 


Ile Ser Ser Leu Asn His Leu Gly Leu Met Tyr Val Phe Leu Phe Leu 
225                 230                 235                 240 


Ser Thr Val Ala Tyr Leu Ala His Gln Pro Glu Met Ser Asn Leu Gly 
                245                 250                 255     


Met Cys Asp Ile Val Gly His Ser His Gln Trp Phe His Val Phe Val 
            260                 265                 270         


Phe Cys Thr Ile Leu Ala Gln Tyr Asn Ala Met Glu Lys Glu Ile Asp 
        275                 280                 285             


Leu Asn Lys Gly Val Ile Ser Glu Val Gln Leu Ser Thr Ile Val Ile 
    290                 295                 300                 


Tyr Phe Leu Leu Leu Leu Ser Leu Asn Ser Val Thr Phe Leu Phe Leu 
305                 310                 315                 320 


Gln Pro Ala Leu Lys Arg Lys Val Val Asp Ile Glu Asn Thr Asn His 
                325                 330                 335     


Ile Lys Gln Lys 
            340 


<210>  147
<211>  363
<212>  PRT
<213>  Capitella sp.

<400>  147

Met Ala Thr Thr Leu Gln Leu Tyr His Val Ser Glu Ile Pro Ser Phe 
1               5                   10                  15      


Phe His Glu Leu Tyr Ile His Arg Gly Tyr Arg His Pro Arg Ser Ser 
            20                  25                  30          


Val Arg Ser Cys Leu Arg Ser Cys Phe Tyr Leu His Asn Glu Thr Val 
        35                  40                  45              


Asn Phe Trp Thr His Phe Ile Pro Ala Val Phe Tyr Leu Phe Val Leu 
    50                  55                  60                  


Val Thr Asp Cys Tyr Gln Tyr Asn Leu Leu Leu Asp Ala Tyr Gly Leu 
65                  70                  75                  80  


Pro Met Leu Ala Tyr Leu Ile Ser Met Thr Leu Phe Pro Thr Ala Ser 
                85                  90                  95      


Ala Leu Ala His Leu Phe Asn Thr Ile Ser Glu Lys Ala Arg His Met 
            100                 105                 110         


Cys Phe Phe Leu Asp Tyr Phe Ala Leu Ser Ile Phe Gly Ile Gly Thr 
        115                 120                 125             


Ala Ile Ala Tyr His Ala Tyr Ser Phe Pro Val Ala Leu Ile Ser Thr 
    130                 135                 140                 


Trp Trp Gln His Leu Tyr Leu Leu Val Ala Val Val Asn Ala Leu Leu 
145                 150                 155                 160 


Ser Phe Val Leu Ser Cys Arg Thr Arg Phe Leu Asp His Gly Leu Arg 
                165                 170                 175     


Lys Lys Met Phe Arg Ile Leu Ser Phe Ala Val Pro Tyr Leu Phe Asp 
            180                 185                 190         


Val Leu Pro Val Cys Tyr Arg Ala Ile His Gly Asp Val Val Asp Phe 
        195                 200                 205             


Ser Leu Gly Gly Met His Tyr His Val Arg Gln Ser Val Phe Ala Phe 
    210                 215                 220                 


Leu Ser Ala Leu Ile Tyr Ser Ser His Leu Pro Glu Arg Leu Ser Pro 
225                 230                 235                 240 


Gly Arg Phe Asp Ile Ile Gly Gln Ser His Gln Leu Phe His Val Val 
                245                 250                 255     


Ser Val Met Gly Thr His Asp Leu Met Thr Gly Met Arg Met Asp Met 
            260                 265                 270         


Leu Gln Arg Arg Gln Leu Met Asp Ala His Gln Pro Ser Tyr Ser Ile 
        275                 280                 285             


Leu Leu Met Val Ala Val Val Gly Phe Asn Leu Val Ile Leu Tyr Tyr 
    290                 295                 300                 


Phe Trp Met Gln Leu Asp Gly Val Ile Leu Lys Ser Thr Ser Ser Glu 
305                 310                 315                 320 


Asp Leu Thr Lys Leu Asn Asn Leu Cys Asn Gly Ala Gly Leu Thr Asn 
                325                 330                 335     


Gly Lys Ser Gly His His Leu Ile Asp Arg Gln Leu Thr Asn Asp Val 
            340                 345                 350         


Ser Arg Arg Ser Lys Leu Arg Pro His Val Glu 
        355                 360             


<210>  148
<211>  352
<212>  PRT
<213>  Capitella sp.

<400>  148

Met Glu Thr Leu Lys Ser Phe Thr Asp Arg Met Val Ala Ser Ser Asn 
1               5                   10                  15      


Gly Leu Val Pro Trp His Glu Val Pro Glu Asp Ser Arg Glu Lys Tyr 
            20                  25                  30          


Ile Leu Thr Gly Tyr Arg Arg Pro Asn Glu Gly Gln Trp Leu Ser Cys 
        35                  40                  45              


Ile Gly Ser Ala Phe Gln Trp His Asn Glu Thr Ile Asn Ile Trp Thr 
    50                  55                  60                  


His Leu Leu Pro Ala Phe Tyr Phe Ile Tyr Phe Ala Leu Met Ala Leu 
65                  70                  75                  80  


Arg Cys Glu His Val Pro Asn Asn Ser Leu Phe Ala Phe Tyr Gly Tyr 
                85                  90                  95      


Leu Leu Ala Val Cys Ser Leu Phe Leu Val Ser Ser Ala Ala His Leu 
            100                 105                 110         


Cys Thr His Cys His Phe Leu Lys Asp Ile Phe Phe Met Met Asp Tyr 
        115                 120                 125             


Ser Ala Ile Ser Phe Tyr Gly Val Gly Ala Ser Ile Ala Val Phe Ala 
    130                 135                 140                 


Tyr Ser Arg Pro Lys His Gln Ile Leu Val Asp Thr Glu Glu Ala Phe 
145                 150                 155                 160 


Leu Ile Gly Ile Val Ile Leu Ala Ile Ala Ala Ser Trp Thr Ser Cys 
                165                 170                 175     


Trp Thr Arg Ile Ser Gln Ser Ser Leu Gly His Leu Ile Arg Thr Ser 
            180                 185                 190         


Ala Tyr Ala Ala Pro Phe Val Tyr Gly Ser Met Pro Ala Val Ala Arg 
        195                 200                 205             


Cys Phe His Asp Ile Ser Leu Pro Pro Thr Asn Ile Thr Thr Gly His 
    210                 215                 220                 


Asn Thr Gly Asp Glu Ala Leu Pro Val Ile Asp Lys Tyr Ser Phe Ile 
225                 230                 235                 240 


Gln Met Tyr Ile Trp His Phe Val Leu Met Ala Ser Ala Gly Leu Val 
                245                 250                 255     


Asn Ile Ser Arg Val Pro Glu Cys Trp Phe Pro Gly Thr Phe Asp Leu 
            260                 265                 270         


Ile Gly Ser Ser His Gln Trp Phe His Val Leu Ile Phe Leu Ser Ile 
        275                 280                 285             


Arg Gln Gln Phe Trp Phe Thr Val Ser Asp Ile Cys Val Pro Asn Arg 
    290                 295                 300                 


His Ile Ser Ala Ser Met Tyr Gly His Tyr Phe Asn Gly Trp Tyr Leu 
305                 310                 315                 320 


Leu Ser Ala Phe Ala Val Thr Leu Ile Ala Leu Ala Phe Ile Ile Thr 
                325                 330                 335     


Phe Ser Phe Lys Asn Ile His Glu Glu Lys Pro Val Val Lys Gln Glu 
            340                 345                 350         


<210>  149
<211>  348
<212>  PRT
<213>  Capitella sp.

<400>  149

Met Ser Arg Val Gln Ser Thr Pro Ile Phe Gly Thr Thr Lys Thr Arg 
1               5                   10                  15      


Phe Arg Ser Leu Pro Arg Val Pro Ser Leu Pro Val Phe Val Pro Thr 
            20                  25                  30          


Arg Ser Lys Ala Gln Val Pro Leu Leu Phe Arg Glu Ala Tyr Val Asp 
        35                  40                  45              


His Gly Phe Arg Glu Leu His Arg Pro Trp Trp Ser Tyr Leu Leu Ser 
    50                  55                  60                  


Val Leu Gln Leu His Asn Glu Ser Met Asn Val Trp Thr His Leu Val 
65                  70                  75                  80  


Ala Leu Val Leu Met Leu Lys His Leu His Thr Phe Asn Gln His Leu 
                85                  90                  95      


Asp Phe Leu Thr Asp Pro Tyr Ser Trp Pro Leu Leu Ala Gly Phe Val 
            100                 105                 110         


Cys Gly Leu Leu Leu Tyr Ser Phe Ser Ser Met Ala His Cys Phe His 
        115                 120                 125             


Ser Lys Ser Glu Leu Val His Tyr Leu Ala Phe Met Val Asp Tyr Ala 
    130                 135                 140                 


Gly Ile Gly Leu Tyr Gly Leu Gly Ser Thr Ile Ile His Phe Tyr Tyr 
145                 150                 155                 160 


Cys Thr Glu Leu Glu Leu His Leu Phe Thr Gln Asn Phe Phe Val Pro 
                165                 170                 175     


Val Gly Cys Ala Leu Ala Phe Leu Val Phe Phe Cys Cys Ser Tyr Ala 
            180                 185                 190         


Lys Val Ser Tyr Ser Arg Pro Tyr Pro Phe Val Arg Lys Val Trp Gln 
        195                 200                 205             


Met Val Pro Val Leu Gly Val Tyr Phe His Leu Ser Ile Pro Leu Val 
    210                 215                 220                 


His Arg Phe Ile Leu Cys Leu Thr Ser Ser Ser Ala Cys Pro Pro Ser 
225                 230                 235                 240 


Ile Gln His His Ala Gln Gln Met Val Trp Phe Ile Leu Ser Gly Ile 
                245                 250                 255     


Phe Tyr Ala Ser Asp Leu Pro Gln Arg Phe His Pro Gly Arg Phe Asp 
            260                 265                 270         


His Phe Phe His Ser His Gln Leu Phe His Ile Cys Ile Met Met Ser 
        275                 280                 285             


Thr Ser Lys Gln Met Asp Ala Val Leu Leu Asp Tyr Gln Met Arg Leu 
    290                 295                 300                 


Ala Ala Ile Leu Ala Gln Pro Glu Pro Ser Leu Phe Ser Ala Phe Gly 
305                 310                 315                 320 


Pro Val Ala Val Val Leu Ala Ala Gln Ile Ile Ser Phe Cys Phe Phe 
                325                 330                 335     


Arg Ser Ile Val Lys Arg Lys Leu Ala Lys Arg Asp 
            340                 345             


<210>  150
<211>  336
<212>  PRT
<213>  Capitella sp.

<400>  150

Met Asp Phe Val Phe Gln Lys Thr Leu Pro Asp Ser Asp Val Gly Leu 
1               5                   10                  15      


Leu Phe Arg Glu Pro Phe Ile Lys Thr Gly Tyr Arg Gln Pro Tyr Arg 
            20                  25                  30          


Pro Trp Ser Tyr Tyr Ile Gly Ser Leu Phe Arg Val His Asn Glu Thr 
        35                  40                  45              


Leu Asn Val Trp Ser His Leu Ala Tyr Leu Ala Ile Phe Leu Arg His 
    50                  55                  60                  


Val Tyr Val Leu Arg Ala Glu Leu Asp Tyr Ser Ala Asp Pro Leu Ala 
65                  70                  75                  80  


Trp Pro Met Leu Gly Phe Ala Ala Gly Thr Ile Ala Tyr Thr Ala Leu 
                85                  90                  95      


Ser Ala Met Ala His Leu Leu Gln Ser Arg Ser Glu Met Ser His Tyr 
            100                 105                 110         


Val Cys Tyr Gln Leu Asp Tyr Ala Gly Ile Gly Leu Asn Ala Val Gly 
        115                 120                 125             


Asn Gly Leu Leu Val Tyr Tyr Met Val Ala Thr Glu Thr Phe Tyr Arg 
    130                 135                 140                 


Trp Phe Gly Trp Phe Phe Ile Pro Val Asn Phe Leu Leu Gly Phe Phe 
145                 150                 155                 160 


Asp Cys Ala Cys Met Gly Val Ala Met Leu Trp Phe Pro Lys Pro Tyr 
                165                 170                 175     


Pro Tyr Gln Arg Lys Ile Trp Gln Met Gly Ser Thr Gly Phe His Val 
            180                 185                 190         


Leu Phe Ala Met Trp Pro Leu Ala His Lys Ile Val Glu Thr Leu Tyr 
        195                 200                 205             


Ser Gln Gly Thr Met Ser Pro Ser Val Val Leu Pro His Ala His Tyr 
    210                 215                 220                 


Ser Ala Trp Phe Leu Phe Ser Val Ser Phe Phe Ala Ser His Val Pro 
225                 230                 235                 240 


Glu Arg Leu Leu Pro Gly Ala Phe Asp Met Val Gly His Gly His Gln 
                245                 250                 255     


Ile Phe His Leu Ala Val Gly Tyr Cys Ser Trp Leu Gln Tyr Glu Val 
            260                 265                 270         


Gly Leu Leu Glu Met Lys Thr Arg Pro Arg His Leu Val Ala Met Ala 
        275                 280                 285             


Asn Pro Asn Gly Thr Thr Ile Phe Gly Gly Ile Leu Ala Val Val Leu 
    290                 295                 300                 


Gly Asp Leu Ile Phe Leu Val Cys Thr His Asn Trp Arg Lys Lys Ile 
305                 310                 315                 320 


Cys Ala Glu Asp Val Lys Arg Arg Leu Arg Arg Lys Lys Arg Leu Glu 
                325                 330                 335     


<210>  151
<211>  349
<212>  PRT
<213>  Nematostella vectensis

<400>  151

Met Lys Tyr Leu Tyr Asn Trp Arg Leu Gly Gly Leu Ala Arg Asn Gln 
1               5                   10                  15      


Gln Arg Thr Pro Gly Ala Ser Glu His Leu Gly Leu Val Gln Lys Glu 
            20                  25                  30          


Ser Gly Arg Asp Gly Lys Gly His Gly Lys Met Val Tyr Arg Arg Leu 
        35                  40                  45              


Val Pro Val Glu Ile Pro Asp Asn Asn Asn Glu Asn Glu Leu Lys Val 
    50                  55                  60                  


Leu Arg Ala Leu Glu Lys Asp Glu Glu Thr Lys Glu Asn Ala Cys Asp 
65                  70                  75                  80  


Leu Pro Pro Lys Leu Cys Ser Leu Gln Cys Cys Pro Ser Trp Leu Gln 
                85                  90                  95      


Phe Asn Lys Phe Val Leu Thr Gly Tyr Arg Cys Asp Tyr Thr Val Ser 
            100                 105                 110         


Glu Cys Leu Asp Ser Leu Leu Tyr Val His Asn Glu Ser Val Asn Ile 
        115                 120                 125             


Tyr Ser His Gly Ile Pro Cys Val Leu Met Met Ile Leu Ile Pro Leu 
    130                 135                 140                 


Thr Ala Ser Gln Ala Cys Leu Glu Ser Ser Phe Trp Phe Ser Leu His 
145                 150                 155                 160 


Tyr Phe Ala Cys Phe Ala Pro Phe Phe Ser Ser Pro Ile Tyr His Leu 
                165                 170                 175     


Phe Met Cys His Lys Gln Gly Ser Thr Ala Tyr Asn Gly Leu Leu Thr 
            180                 185                 190         


Phe Asp Met Cys Gly Ile Trp Ala Val Asn Thr Phe Gly Ala Leu Cys 
        195                 200                 205             


Gly Ile Arg Ala Thr Leu Phe Cys Phe Pro Ile Trp Arg Met Thr Ala 
    210                 215                 220                 


Leu Ile Thr Tyr Ile Leu Ile Ser Phe Ile Ser Leu Tyr Phe Ile Leu 
225                 230                 235                 240 


Gly Ala Arg Thr Pro Lys Glu Arg Phe Val Pro Leu Thr Val Phe Gly 
                245                 250                 255     


Val Met Arg Tyr Leu Phe Ile Gly Val Arg Leu Phe Leu Arg Tyr Leu 
            260                 265                 270         


Gly Tyr Gly Cys Gly Ser Asp Gly Ala Leu Pro Tyr Cys Val Leu Met 
        275                 280                 285             


Asp Leu Phe Ala Cys Val Gly Gly Val Ile Asn Ile Ala Arg Val Pro 
    290                 295                 300                 


Glu Lys Trp Phe Pro Gly Gln Phe Asp Ile Ile Gly Asn Ser His Gln 
305                 310                 315                 320 


Ile Met His Val Leu Ser Val Ile Ser Val Ile Phe Leu His Leu Gly 
                325                 330                 335     


Ser Ser Lys Glu Phe Glu Trp Met Ala Glu Tyr Lys Cys 
            340                 345                 


<210>  152
<211>  342
<212>  PRT
<213>  Nematostella vectensis

<400>  152

Met Ile Asn Asn Asn Asn Asn Leu Lys Gln His Thr Glu Val Leu Glu 
1               5                   10                  15      


Lys Thr Leu Leu Gly Asp Arg Ala Val Asp Phe Glu Phe Arg Glu Pro 
            20                  25                  30          


Phe Ile Val Ser Gly Tyr Arg Arg Pro Gly Phe Ser Phe Lys Gln Cys 
        35                  40                  45              


Ile His Ser Ala Phe Tyr Ala His Asn Glu Thr Ile Asn Val Trp Ser 
    50                  55                  60                  


His Ile Leu Ala Leu Val Gly Phe Leu Tyr His Cys Leu Pro Val Phe 
65                  70                  75                  80  


Cys Leu Arg Ser Asn Pro Phe Thr Asp Pro Phe Val Tyr Pro Leu Leu 
                85                  90                  95      


Ser Phe Ser Leu Gly Ile Ser Ala Met Phe Leu Met Ser Ser Ser Ala 
            100                 105                 110         


His Leu Phe Asn Cys Met Ser Ala Lys Val Arg His Ile Cys Phe Phe 
        115                 120                 125             


Phe Asp Tyr Ala Ala Ile Ser Thr Tyr Thr Phe Thr Ala Gly Leu Val 
    130                 135                 140                 


Phe Tyr Tyr Tyr Ser Arg Pro Thr Asn Thr Asp Leu Lys Leu Met Asn 
145                 150                 155                 160 


Ser Asn Cys Leu Phe Leu Cys Ile Ser Ala Ala Ile Ser Leu Ala Thr 
                165                 170                 175     


Thr Tyr Leu Cys Cys Ala Ser Arg His Lys Trp Val Gln His Lys Phe 
            180                 185                 190         


Leu Leu Arg Thr Gly Thr Phe Val Ile Ser Trp Leu Phe Asn Thr Leu 
        195                 200                 205             


Pro Phe Thr Thr Arg Ala Ile Tyr Cys Asp Ser Lys Leu Glu Cys Asn 
    210                 215                 220                 


Thr Val Ala Phe Ala Tyr Phe Lys Arg Gln Val Phe Tyr Phe Phe Leu 
225                 230                 235                 240 


Ala Ala Leu Ser Asn Val Ile Arg Ile Pro Glu Arg Phe Ile Pro Gly 
                245                 250                 255     


Leu Phe Asp Phe Phe Gly Gln Ser His His Phe Leu His Ile Leu Cys 
            260                 265                 270         


Ser Leu Gly Ala Ile Asp Asp Phe Val Ala Val Glu Leu Asp Met Asn 
        275                 280                 285             


Ile Arg Arg Glu Ile Leu His Ala Ser Ser Thr Val Leu Pro Thr Phe 
    290                 295                 300                 


Gly Asn Ser Leu Gly Leu Met Ile Ala Val Leu Leu Gly Asn Ile Ala 
305                 310                 315                 320 


Ile Val Ile Trp Phe Ala Val His Cys Pro Val Ser Leu Gln Ile Asp 
                325                 330                 335     


Lys Gln Leu Lys Thr Lys 
            340         


<210>  153
<211>  382
<212>  PRT
<213>  Nematostella vectensis

<400>  153

Met Ser Cys Lys Glu Ser Asn Gly Asp Ala His Gln Asn Gly Lys His 
1               5                   10                  15      


His Asp Val Asn Arg Asn Gln Gln Trp Pro Phe Asp Asp Thr Lys Gly 
            20                  25                  30          


Ala Leu Ser Gly Arg Lys Gly Leu Arg Phe Val His Glu Leu Pro Pro 
        35                  40                  45              


Ser Tyr His Glu Pro Phe Ile Leu Ser Gly Tyr Arg Asn Pro Gly Asn 
    50                  55                  60                  


Phe Ser Leu Arg Gln Cys Leu Val Thr Ala Phe Ser Leu His Asn Glu 
65                  70                  75                  80  


Thr Ile Asn Ile Trp Ser His Leu Ile Ala Phe Ile Ala Phe Ala Val 
                85                  90                  95      


Tyr Phe Tyr Tyr Lys Phe Gln Ala Leu Gly Val Gly Phe Thr Phe Gly 
            100                 105                 110         


Pro Thr Gly Tyr Pro Leu Met Cys Phe Ala Phe Gly Ile Cys Leu Val 
        115                 120                 125             


Phe Ile Ser Ser Ala Gly Ala His Leu Phe Cys Cys Leu Ser Glu Glu 
    130                 135                 140                 


Cys Arg His Ile Cys Phe Tyr Leu Asp Tyr Ala Ala Ile Ser Val Phe 
145                 150                 155                 160 


Thr Leu Thr Ala Ala Gln Ala Phe Tyr Phe Tyr Ser Arg Pro Ser Gly 
                165                 170                 175     


Lys Thr Leu Phe Ile Phe Asp Ser Pro His Leu Tyr Leu Gly Ile Ser 
            180                 185                 190         


Ala Phe Leu Ser Val Val Asn Val Ala Leu Ser Cys Leu Ser Arg His 
        195                 200                 205             


Tyr Leu Arg Asp Phe Arg Phe Leu Leu Arg Ala Gly Pro Asn Leu Ile 
    210                 215                 220                 


Lys Ile Leu Tyr Asp Thr Trp Pro Phe Val Ala Arg Ile Asn His Cys 
225                 230                 235                 240 


Thr Met Ala Thr Asp Cys Asn Ala Ile Ala Val Thr Leu Phe Tyr Arg 
                245                 250                 255     


His Trp Leu Cys Tyr Gly Ile Ser Gly Ile Thr Tyr Ala Ala Lys Ile 
            260                 265                 270         


Pro Glu Arg Trp Met Pro Gly Val Phe Asp Phe Phe Gly His Ser His 
        275                 280                 285             


His Phe Leu His Ile Val Thr Ile Phe Gly Asn Tyr Tyr Ala Phe Leu 
    290                 295                 300                 


Ala Val Ser Leu Asp Met Thr Asn Arg Ala Glu Leu Leu Ser Lys Leu 
305                 310                 315                 320 


Pro Val Gln Pro Thr Val Phe Thr Thr Phe Gly Met Leu Leu Ile Val 
                325                 330                 335     


Leu Leu Ser Gly Gly Ile Ile Thr Trp Val Phe Ile Tyr Arg Phe Leu 
            340                 345                 350         


Gln Gln Asp Arg Gly Ala Asp Glu Tyr Val Gly Gly Thr Gln Tyr Thr 
        355                 360                 365             


Val Ile Tyr Arg Arg Lys Gly Asn Tyr Glu Lys Lys Thr Ser 
    370                 375                 380         


<210>  154
<211>  342
<212>  PRT
<213>  Nematostella vectensis

<400>  154

Met Ile Cys Asn Glu Lys Ser Thr Ala Ala Ile Gly Asn Asn Asn Leu 
1               5                   10                  15      


Ser Lys Leu Ser Ala Val Leu Gln Ser Pro Leu Glu Leu Val Phe Asp 
            20                  25                  30          


Cys Asp Ile Pro Glu Gly Phe Arg Thr Pro Phe Ile Lys Thr Gly Tyr 
        35                  40                  45              


Arg Lys Pro Gly Leu Thr Met Trp Gly Cys Phe Lys Ser Leu Ile Glu 
    50                  55                  60                  


Pro Thr Asn Glu Thr Val Asn Val Trp Thr His Val Leu Ala Leu Val 
65                  70                  75                  80  


Leu Phe Leu Leu Arg Phe Ser Asn Val Phe Ser Asn Ser Asp Phe Asp 
                85                  90                  95      


Pro Trp Cys Tyr Gly Leu Val Cys Phe Ala Ile Gly Ile Ala Ser Leu 
            100                 105                 110         


Met Ala Met Ser Ser Ser Ala His Leu Ile Asn Cys Met Ser Leu Ser 
        115                 120                 125             


Ala His His Ile Gly Phe Tyr Leu Asp Tyr Ala Ala Ile Cys Val Tyr 
    130                 135                 140                 


Ser Phe Ser Gly Ser Gln Ala Phe Phe Phe Tyr Ser Arg Pro Ser Gln 
145                 150                 155                 160 


Thr Asp Phe Val Leu Leu Ser Ser Pro Thr Val Phe Leu Thr Val Ser 
                165                 170                 175     


Ala Ile Met Ser Cys Leu Cys Thr Ala Val Cys Cys Ala Ser Arg His 
            180                 185                 190         


Arg Trp Leu Arg Ser Lys Tyr Val Ile Arg Thr Ser Met Phe Met Leu 
        195                 200                 205             


Tyr Phe Ile Ile Val Thr Ser Pro Phe Thr Tyr Arg Leu Ala Tyr Ser 
    210                 215                 220                 


Thr Ala Glu Ser Glu Thr Ser Arg Ala Val His Tyr Phe Asn Arg His 
225                 230                 235                 240 


Ile Ile Asn Tyr Ile Leu Ser Ala Phe Val Asn Val Thr Lys Leu Pro 
                245                 250                 255     


Glu Arg Tyr Phe Pro Arg Leu Phe Asp Phe Leu Gly Gln Ser His His 
            260                 265                 270         


Phe Leu His Ile Leu Ala Ala Leu Gly Ala Ala Asp Ala Phe Thr Ala 
        275                 280                 285             


Thr Asn Leu Asp Met Lys Thr Arg Gln Asp Leu Leu Ala Gly Leu Pro 
    290                 295                 300                 


Gly Pro Asn Leu Trp Asn Thr Phe Gly Val Phe Phe Thr Val Ala Phe 
305                 310                 315                 320 


Thr Asn Leu Phe Ile Val Tyr Leu Phe Ser Lys Ala Leu Leu Lys Gln 
                325                 330                 335     


Glu Lys Glu Lys Ser Asn 
            340         


<210>  155
<211>  315
<212>  PRT
<213>  Nematostella vectensis

<400>  155

Met Ser Leu Ser Ala Glu Glu Val Pro Leu Gln Phe Arg Glu Gln Phe 
1               5                   10                  15      


Ile Ile Ser Gly Tyr Arg Arg Pro Tyr Ala Ser Ala Arg Asp Cys Ile 
            20                  25                  30          


Lys Ser Ala Phe Gly Pro Tyr Asn Glu Thr Leu Asn Phe Trp Thr His 
        35                  40                  45              


Phe Val Pro Phe Leu Leu Phe Ser Ala Arg Phe Val Trp Thr Phe His 
    50                  55                  60                  


Arg Asp Gly Ile Asp Leu Tyr Arg Leu Pro Leu Val Ser Phe Ala Leu 
65                  70                  75                  80  


Gly Ile Cys Gly Phe Leu Leu Met Ser Ser Cys Ala His Leu Phe Asn 
                85                  90                  95      


Ser Met Ser Pro Arg Ile Arg His Cys Cys Phe Phe Cys Asp Tyr Ser 
            100                 105                 110         


Ala Ile Ser Val Tyr Ser Val Gly Ala Gly Leu Ser Phe Tyr Phe Tyr 
        115                 120                 125             


Ser Arg Pro Ile Gly Val Gly Val Phe Pro Pro Pro Lys Val Tyr Ile 
    130                 135                 140                 


Thr Gly Ser Ile Leu Ile Ser Leu Leu Ser Thr Thr Leu Cys Cys Ala 
145                 150                 155                 160 


Ser Arg His Arg Trp Ala Asn Tyr Lys Tyr Ala Ile Arg Thr Gly Ser 
                165                 170                 175     


Phe Val Leu Ala Phe Leu Tyr Asn Cys Leu Pro His Phe Tyr Arg Phe 
            180                 185                 190         


Ile Ile Glu Gly Ala Asp Lys Leu Asp Pro Val Ala Met Ser Tyr Phe 
        195                 200                 205             


Lys Arg His Thr Val Phe Tyr Leu Leu Ala Ala Val Ala Asn Thr Thr 
    210                 215                 220                 


Arg Ile Pro Glu Arg Leu Ile Pro Gly Val Phe Asp Val Ile Gly His 
225                 230                 235                 240 


Ser His Asn Phe Leu His Ile Phe Thr Ala Leu Gly Val Ala Asp Gln 
                245                 250                 255     


Tyr Thr Ala Met Glu Leu Glu Met Ile His Arg Glu Pro Ile Leu Lys 
            260                 265                 270         


His Leu His Val Asp Val Tyr Ser Lys Ser Leu Asn Leu Met Ile Cys 
        275                 280                 285             


Ala Leu Leu Ala Asn Ile Gly Ile Val Val Leu Phe Gly Val Arg Leu 
    290                 295                 300                 


Lys Ser Asn Lys Glu Glu Glu His Lys Ile Leu 
305                 310                 315 


<210>  156
<211>  301
<212>  PRT
<213>  Nematostella vectensis

<400>  156

Ile Pro Pro Glu Tyr Arg Asp Arg Tyr Ile Arg Ser Gly Tyr Arg Lys 
1               5                   10                  15      


Pro Gly Leu Thr Phe Leu Glu Cys Leu Gln Ser Leu Phe His Trp Asn 
            20                  25                  30          


Asn Glu Val Leu Asn Val Trp Thr His Tyr Ile Thr Leu Leu Phe Phe 
        35                  40                  45              


Thr Trp Lys Phe Cys Asn Leu Gly Arg Asp Leu Ser Gln Pro Glu Tyr 
    50                  55                  60                  


Tyr Pro Leu Leu Ala Tyr Ala Ile Gly Ala Cys Met Phe Pro Leu Leu 
65                  70                  75                  80  


Ser Cys Ile Ala His Thr Phe Ser Ser Met Ser Ile Ser Val Arg His 
                85                  90                  95      


Ile Cys Phe Phe Cys Asp Tyr Ala Gly Ile Ser Leu Tyr Ser Ile Gly 
            100                 105                 110         


Ser Ser Val Ala Tyr Phe Phe Tyr Thr Ile Pro Pro Asp Val Lys Ser 
        115                 120                 125             


Thr Trp Leu Gly Trp Ala Tyr Pro Pro Leu Asn Val Leu Met Ala Ala 
    130                 135                 140                 


Ser Cys Cys Tyr Val Cys Cys Ile Ser Arg Ala Lys Gln Trp Ser Lys 
145                 150                 155                 160 


Tyr Gln Thr Val Met Arg Ala Cys Ser Phe Ala Val Pro Tyr Val Phe 
                165                 170                 175     


Cys Ser Ser Phe Ile Leu His Lys Leu Leu Ile Ser Arg Asn Ser Pro 
            180                 185                 190         


Ser Ser Ser Trp Phe His Cys Ser Gln Phe Phe Trp Cys Thr Leu Met 
        195                 200                 205             


Ala Ile Ala Met Thr Thr Lys Val Pro Glu Lys Tyr Phe Met Glu Tyr 
    210                 215                 220                 


Phe Asp Ile Val Gly His Ser His Gln Trp Phe His Ile Phe Val Ser 
225                 230                 235                 240 


Val Gly Thr Asn Gln Gln Ile Asn Ala Val Leu Leu Asp Met Ile Asp 
                245                 250                 255     


Leu Glu Asn Thr Gly Gln Leu Pro Leu Val Ser Phe Leu Ser Ser Val 
            260                 265                 270         


Gly Leu Val Leu Leu Val Ala Leu Val Asp Thr Ala Ile Val Val Tyr 
        275                 280                 285             


Phe Ser Arg Lys Ile Leu Gln Lys Lys Ile Lys Pro Ser 
    290                 295                 300     


<210>  157
<211>  356
<212>  PRT
<213>  Trichoplax adhaerens

<400>  157

Met Phe Asp Leu Lys Gln Asn Gly Asn Glu Asn Ile Thr Glu Thr Asn 
1               5                   10                  15      


Ala Lys Ala Ala Val Glu Ala Ser Leu Glu Lys Gly Asn Asn Asp Glu 
            20                  25                  30          


Ser Ser Lys Ile Pro Glu Val Arg Tyr Ser Thr Tyr Tyr Asn Gly Lys 
        35                  40                  45              


Lys Val Asn Val Tyr Arg Val Val Val Gln Pro Pro Asn Asp Trp Lys 
    50                  55                  60                  


Thr Leu Pro Phe Asn Lys Leu Pro Asp Trp Leu Gln Asp Asn Glu Phe 
65                  70                  75                  80  


Leu Val Lys Gly Tyr Arg Pro Gln Leu Pro Ser Val Ser Leu Cys Leu 
                85                  90                  95      


Arg Ser Ile Phe Arg Ile His Thr Glu Thr Gly Asn Ile Trp Thr His 
            100                 105                 110         


Leu Leu Gly Phe Ile Gly Leu Leu Ile Phe Ala Ile Tyr Cys Phe Ser 
        115                 120                 125             


Val Pro Leu Ser Gln Lys Thr Trp Gln Glu Gln Ala Val Phe Gly Ala 
    130                 135                 140                 


Phe Phe Ala Gly Ala Ile Thr Cys Leu Leu Phe Ser Ser Phe Phe His 
145                 150                 155                 160 


Thr Ile Tyr Cys Tyr Ser Phe Arg Val Met Lys Ser Ser Ala Lys Leu 
                165                 170                 175     


Asp Tyr Leu Gly Ile Ala Thr Leu Val Val Gly Ser Asn Val Ser Leu 
            180                 185                 190         


Ile Tyr Tyr Ala Phe Tyr Cys Tyr Thr Ile Pro Leu Ile Ile Tyr Glu 
        195                 200                 205             


Thr Val Ala Ile Val Leu Gly Thr Ala Ala Ala Ile Val Ser Leu Phe 
    210                 215                 220                 


Asp Lys Phe Ser Glu Ser Lys Tyr Arg Thr Phe Arg Ala Ala Leu Phe 
225                 230                 235                 240 


Gly Gly Val Gly Gly Ser Gly Val Val Pro Leu Leu His Tyr Cys Gly 
                245                 250                 255     


Ile Thr Gly Phe Tyr Arg Ala Ile Glu Ile Gly Gly Ile Pro Trp Phe 
            260                 265                 270         


Leu Ala Ser Gly Leu Ser Tyr Leu Val Gly Val Thr Leu Tyr Ala Thr 
        275                 280                 285             


Arg Thr Pro Glu Arg Phe Phe Pro Gly Arg Cys Asp Ile Val Phe Gln 
    290                 295                 300                 


Ser His Gln Leu Phe His Val Phe Val Val Val Gly Ala Ile Leu Thr 
305                 310                 315                 320 


Tyr Cys Ser Leu Asn Ser Tyr Ala Asp Tyr His Gln Leu Val Gly His 
                325                 330                 335     


Asn Cys Ser Val Val His Ser Ile Phe Lys Asn Gly Phe Val Thr Gln 
            340                 345                 350         


Leu Arg Arg Ser 
        355     


<210>  158
<211>  315
<212>  PRT
<213>  Trichoplax adhaerens

<400>  158

Met Thr Thr Phe Val Phe Arg Arg Ser Arg Ile Arg Ser Arg Phe Arg 
1               5                   10                  15      


Ser Ile Ser Gly Asp Gln Lys Lys Glu Cys His Gly Ser Ile Gln Leu 
            20                  25                  30          


Tyr Asn Ile Ser Gln Val Pro Pro Phe Leu Lys Phe Asn Pro His Ile 
        35                  40                  45              


Tyr Ser Gly Tyr Arg Val Asn Leu Ser Tyr Gln Ser Cys Leu Lys Ser 
    50                  55                  60                  


Leu Phe Val Leu Ser Asn Glu Ser Ile Asn Ile Trp Ser His Phe Leu 
65                  70                  75                  80  


Gly Phe Phe Ile Phe Val Tyr Leu Leu Val Phe Asp Asn Val Tyr Val 
                85                  90                  95      


Val Pro Trp Thr Leu Gln Ser Met Pro Asp Arg Ile Val Ile Ser Ser 
            100                 105                 110         


Ala Cys Leu Phe Tyr Met Ser Thr Leu Leu Leu Ser Thr Leu Tyr His 
        115                 120                 125             


Leu Phe His Cys His Ser Glu Arg Met Asn Gln Leu Trp Leu Lys Met 
    130                 135                 140                 


Asp Ile Gly Gly Ile Gly Ile Gly Ile Ile Gly Gly Phe Val Ser Gly 
145                 150                 155                 160 


Leu Tyr Val Ala Tyr Tyr Cys His Arg Tyr Trp Leu Leu Ile Tyr Val 
                165                 170                 175     


Ile Val Ser Thr Leu Leu Ile Ser Thr Ser Val Tyr Asn Leu Ala Cys 
            180                 185                 190         


Ser Asp Ala Lys Gly Ile Gln Phe Gln Ile Ser Asn Leu Asn Phe Arg 
        195                 200                 205             


Met Asn Arg Thr Val Val Phe Val Ile Ile Val Ala Phe Ser Leu Val 
    210                 215                 220                 


Pro Ile Phe His Phe Ile Tyr Leu His Asp Gly Ile Ser Ser Thr Phe 
225                 230                 235                 240 


Val Arg Gln Phe Thr Ile Gly Ala Ser Tyr Met Leu Phe Tyr Gly Leu 
                245                 250                 255     


Met Gly Cys Leu Phe Leu Val Thr Lys Phe Pro Glu Arg Leu Phe Pro 
            260                 265                 270         


Gly Lys Phe Asp Tyr Val Ala Ser Ser His Gln Phe Trp His Leu Phe 
        275                 280                 285             


Val Phe Leu Leu Phe Tyr Ser Trp His Gln Ser Cys Leu Asp Ala Val 
    290                 295                 300                 


Gln Tyr Arg Ile Lys Asn Gln Cys Glu Ile Ile 
305                 310                 315 


<210>  159
<211>  320
<212>  PRT
<213>  Trichoplax adhaerens

<400>  159

Met Ala Ala Gln Asn Gln Leu Leu Asp Ala Asp Gln Ile Pro Ala Ile 
1               5                   10                  15      


Phe Arg Asp Asp His Ile Ile Arg Gly Tyr Arg Lys Pro Gly Leu Thr 
            20                  25                  30          


Val Ile Gln Cys Ile Lys Ser Met Leu Gln Met Asn Asn Glu Thr Val 
        35                  40                  45              


Asn Phe Trp Thr His Met Ile Pro Phe Leu Tyr Phe Leu Ile Arg Phe 
    50                  55                  60                  


Tyr Thr Ile Asp Gln Gln Tyr Gln Leu Val Glu Asp Pro Phe Tyr Trp 
65                  70                  75                  80  


Pro Leu Leu Cys Tyr Ile Val Gly Ser Ser Tyr Pro Leu Phe Ser Cys 
                85                  90                  95      


Ile Ala His Ala Leu Asn Cys Met Ser Glu Ser Ala Arg His Ile Cys 
            100                 105                 110         


Phe Phe Leu Asp Tyr Ala Ser Ile Ser Leu Tyr Ser Phe Thr Cys Ala 
        115                 120                 125             


Ile Ala Tyr Phe Tyr Tyr Leu Arg Pro Val Thr Phe Phe Thr Met Asp 
    130                 135                 140                 


Trp Tyr Ile Thr Leu Ser Ser Met Met Ala Ile Cys Cys Cys Leu Thr 
145                 150                 155                 160 


Ser Cys Ile Ser Arg Leu Tyr Ala His Thr Ser Arg Pro Tyr Ile Tyr 
                165                 170                 175     


Arg Thr Leu Ala Phe Ala Leu Gln Trp Val Tyr Val Asn Ser Met Leu 
            180                 185                 190         


Ala Tyr Arg Ile Phe Ser Cys His His His Gln Cys Arg Leu Thr Ser 
        195                 200                 205             


Asp Tyr Tyr His Thr Met Gln Phe Val Met Ala Ile Leu Val Ala Ile 
    210                 215                 220                 


Phe Met Thr Ser Lys Phe Pro Glu Cys Val Trp Pro Thr Ser Phe Asp 
225                 230                 235                 240 


Ile Cys Gly Gln Ser His His Trp Phe His Ile Phe Val Cys Val Gly 
                245                 250                 255     


His Arg Tyr Gln Leu Asp Gly Ile Leu Asn Asp Ile Gln Gln Arg Gln 
            260                 265                 270         


His Val Ile Arg Leu Ile Lys Pro Thr Phe Ser Ser Thr Leu Gly Val 
        275                 280                 285             


Leu Phe Val Val Ile Ala Cys Asn Ser Ile Ile Val Ile Tyr Phe Ser 
    290                 295                 300                 


Tyr Leu Ile Ile Arg Arg Ser Asn Arg Ala Lys Gln Val Lys Ser Thr 
305                 310                 315                 320 


<210>  160
<211>  310
<212>  PRT
<213>  Trichoplax adhaerens

<400>  160

Lys Leu Leu Thr Ala Lys Gln Ile Pro Ser Phe Tyr Arg Glu Pro Tyr 
1               5                   10                  15      


Ile Leu Ser Gly Tyr Arg Pro Leu Phe Ser Asp Leu Ser Val Cys Phe 
            20                  25                  30          


Arg Ser Leu Phe Gln Arg Thr Asn Glu Thr Leu Asn Val Trp Thr His 
        35                  40                  45              


Leu Ile Pro Cys Leu Tyr Phe Ala Phe Asn Tyr Val Gln Phe Phe Leu 
    50                  55                  60                  


Lys Asn Asp Ile Ser Asp Pro Tyr Val Arg Gly Ile Ile Ile Thr Ala 
65                  70                  75                  80  


Ile Gly Ser Cys Gly Phe Leu Gly Phe Ser Ser Val Ala His Leu Phe 
                85                  90                  95      


Cys Cys Leu Ser Ala Asn Val Arg His Thr Cys Tyr Tyr Ile Asp Tyr 
            100                 105                 110         


Ala Gly Ile Cys Leu Tyr Ser Ile Cys Gly Gly Phe Ser Phe Leu Phe 
        115                 120                 125             


Tyr Ala Arg Pro Ala Leu Glu Ala Asp Ser Asp Trp Phe Tyr Arg His 
    130                 135                 140                 


Arg Ile Leu Phe Leu Ser Ile Ser Val Val Ile Ser Asn Val Ile Cys 
145                 150                 155                 160 


Leu Leu Thr Cys Ile Ser Arg His Lys Trp Leu Arg Phe Arg Tyr Leu 
                165                 170                 175     


Ile Arg Thr Leu Ala Phe Thr Val Pro Tyr Phe Tyr Asn Ala Leu Pro 
            180                 185                 190         


Leu Phe Tyr Arg Ile Ser Ser Cys Pro Val Asp Ala Cys Asn Pro Glu 
        195                 200                 205             


Ala Leu Arg Tyr Tyr Tyr Leu Asn Trp Phe Trp Tyr Ala Met Ser Phe 
    210                 215                 220                 


Val Ser Asn Ile Ala Arg Leu Pro Glu Arg Leu Ala Pro Gly Gln Phe 
225                 230                 235                 240 


Asp Ile Ile Gly His Ser His Gln Trp Leu His Ile Phe Leu Ala Phe 
                245                 250                 255     


Gly Asn Asp Ala Phe Ile Lys Gly Ile Met Ser Asp Phe Thr His Arg 
            260                 265                 270         


Arg Asn Gln Leu Leu Leu Thr Ser Lys Val Thr Asp Leu Ser Tyr Glu 
        275                 280                 285             


Phe Thr Ile Val Ile Val Gly Ile Leu Asn Leu Met Val Ile Ile Ala 
    290                 295                 300                 


Val Tyr Asn Ala Leu Leu 
305                 310 


<210>  161
<211>  322
<212>  PRT
<213>  Trichoplax adhaerens

<400>  161

Met Thr Glu Met Arg Lys Ser Asn Ser Ile Ser Tyr Leu Pro Val His 
1               5                   10                  15      


Gln Met Pro Thr Gln Tyr Arg Glu Pro Tyr Ile Leu Thr Gly Tyr Arg 
            20                  25                  30          


Glu Pro Cys Ser Thr Cys Lys Ser Cys Leu Arg Ser Leu Ile Arg Ala 
        35                  40                  45              


Ser Asn Glu Thr Leu Asn Val Trp Thr His Phe Leu Pro Ile Ile Tyr 
    50                  55                  60                  


Phe Leu Asn Arg Ala Ile Gln Phe Tyr Ser Asn Asn Asp Ser Gly Cys 
65                  70                  75                  80  


Phe Glu Phe Gln Tyr Tyr Pro Phe Met Pro Asn Tyr Ile Gly Ile Ile 
                85                  90                  95      


Phe Tyr His Leu Ala Ser Ser Ile Ala His Leu Phe Cys Ser Met Ser 
            100                 105                 110         


Ile Lys Tyr Arg His Thr Cys Phe Tyr Ile Asp Tyr Ser Gly Ile Cys 
        115                 120                 125             


Ile Tyr Ala Met Gly Ala Gly Ile Thr Tyr Tyr Asn Leu Tyr Val Leu 
    130                 135                 140                 


Pro Asn Ala Pro Thr Asn Asn Tyr Pro Leu Ser Gln Ile Ala Phe Thr 
145                 150                 155                 160 


Ile Leu Ser Phe Gly Val Ser Leu Ser Val Cys Leu Val Ser Cys Ile 
                165                 170                 175     


Ser Arg His Tyr Trp Arg Ser Thr Gly Ala Val Ile Arg Thr Gly Ala 
            180                 185                 190         


Phe Ala Ile Asn Leu Ile Phe Asn Thr Ser Pro Ser Leu Trp Leu Phe 
        195                 200                 205             


Trp Gln Asn Gln Leu Pro Ser Ala Thr His Leu Val Arg Gln Trp Ser 
    210                 215                 220                 


Trp Tyr Val Ala Ala Ile Thr Ala Tyr Val Phe Lys Ile Pro Glu Lys 
225                 230                 235                 240 


Phe Ala Pro Gly Lys Phe Asp Val Ile Gly His Ser His Gln Trp Phe 
                245                 250                 255     


His Val Phe Leu Ser Leu Gly Thr Val Glu Gln Ile Asn Ser Leu Glu 
            260                 265                 270         


Phe Asp Val Asn Ala Cys Arg Pro Lys Tyr Met Pro Ser Asp Ala Pro 
        275                 280                 285             


Ser Phe Phe Ile Thr Ile Gly Ser Met Met Leu Ala Ile Leu Leu Asn 
    290                 295                 300                 


Ala Leu Ile Val Ser Ile Cys Ser Tyr Lys Leu Ala Arg His Ala Lys 
305                 310                 315                 320 


Met Asp 
        


<210>  162
<211>  207
<212>  PRT
<213>  Trichoplax adhaerens

<400>  162

Met Gly Pro Thr Val Thr Val Lys Arg Leu Arg Phe Met Asn Ala Pro 
1               5                   10                  15      


Val Thr Gly Cys Gln Cys His Tyr Gln Ala Thr Thr Ile Glu Gln Thr 
            20                  25                  30          


Ala Asn Ile Leu Thr His Gly Val Trp Ile Ile Pro Ala Ile Tyr Ala 
        35                  40                  45              


Leu Leu Lys Met Leu Thr Leu Ser Thr Thr Gln Asn Gln Tyr Trp Ile 
    50                  55                  60                  


Ala Trp Cys Met Ile Ser Arg Phe Leu His Phe Trp Asp Arg Ser Thr 
65                  70                  75                  80  


Ile Phe Thr Phe Ile Ala Ser Cys Phe Met Pro Trp Phe Val Leu Thr 
                85                  90                  95      


Glu Thr Leu Ser Asn Thr Tyr Val Met Lys Trp Leu Val Cys Ile Trp 
            100                 105                 110         


Leu Met Ala Met Leu Gly Ile Thr Phe Thr Tyr Leu Phe Leu Asp Arg 
        115                 120                 125             


Tyr Lys Leu Leu Glu Thr Leu Leu Tyr Val Ile Leu Gly Val Val Pro 
    130                 135                 140                 


Ser Ile Pro Ile Leu Tyr Ala Asn Gln Asn Ser Gly Ala Trp Glu Leu 
145                 150                 155                 160 


Thr Ala Gly Gly Gly Ile Tyr Val Met Gly Ile Leu Phe Phe Lys Cys 
                165                 170                 175     


Asp Gly Arg Ile Pro Phe Ala His Ala Ile Trp His Thr Phe Val Ala 
            180                 185                 190         


Cys Gly Ala Leu Ile His Tyr Ser Ala Val Ile Arg Tyr Lys Tyr 
        195                 200                 205         


<210>  163
<211>  431
<212>  PRT
<213>  Saccharomyces cerevisiae


<220>
<221>  MISC_FEATURE
<223>  alpha-factor receptor

<400>  163

Met Ser Asp Ala Ala Pro Ser Leu Ser Asn Leu Phe Tyr Asp Pro Thr 
1               5                   10                  15      


Tyr Asn Pro Gly Gln Ser Thr Ile Asn Tyr Thr Ser Ile Tyr Gly Asn 
            20                  25                  30          


Gly Ser Thr Ile Thr Phe Asp Glu Leu Gln Gly Leu Val Asn Ser Thr 
        35                  40                  45              


Val Thr Gln Ala Ile Met Phe Gly Val Arg Cys Gly Ala Ala Ala Leu 
    50                  55                  60                  


Thr Leu Ile Val Met Trp Met Thr Ser Arg Ser Arg Lys Thr Pro Ile 
65                  70                  75                  80  


Phe Ile Ile Asn Gln Val Ser Leu Phe Leu Ile Ile Leu His Ser Ala 
                85                  90                  95      


Leu Tyr Phe Lys Tyr Leu Leu Ser Asn Tyr Ser Ser Val Thr Tyr Ala 
            100                 105                 110         


Leu Thr Gly Phe Pro Gln Phe Ile Ser Arg Gly Asp Val His Val Tyr 
        115                 120                 125             


Gly Ala Thr Asn Ile Ile Gln Val Leu Leu Val Ala Ser Ile Glu Thr 
    130                 135                 140                 


Ser Leu Val Phe Gln Ile Lys Val Ile Phe Thr Gly Asp Asn Phe Lys 
145                 150                 155                 160 


Arg Ile Gly Leu Met Leu Thr Ser Ile Ser Phe Thr Leu Gly Ile Ala 
                165                 170                 175     


Thr Val Thr Met Tyr Phe Val Ser Ala Val Lys Gly Met Ile Val Thr 
            180                 185                 190         


Tyr Asn Asp Val Ser Ala Thr Gln Asp Lys Tyr Phe Asn Ala Ser Thr 
        195                 200                 205             


Ile Leu Leu Ala Ser Ser Ile Asn Phe Met Ser Phe Val Leu Val Val 
    210                 215                 220                 


Lys Leu Ile Leu Ala Ile Arg Ser Arg Arg Phe Leu Gly Leu Lys Gln 
225                 230                 235                 240 


Phe Asp Ser Phe His Ile Leu Leu Ile Met Ser Cys Gln Ser Leu Leu 
                245                 250                 255     


Val Pro Ser Ile Ile Phe Ile Leu Ala Tyr Ser Leu Lys Pro Asn Gln 
            260                 265                 270         


Gly Thr Asp Val Leu Thr Thr Val Ala Thr Leu Leu Ala Val Leu Ser 
        275                 280                 285             


Leu Pro Leu Ser Ser Met Trp Ala Thr Ala Ala Asn Asn Ala Ser Lys 
    290                 295                 300                 


Thr Asn Thr Ile Thr Ser Asp Phe Thr Thr Ser Thr Asp Arg Phe Tyr 
305                 310                 315                 320 


Pro Gly Thr Leu Ser Ser Phe Gln Thr Asp Ser Ile Asn Asn Asp Ala 
                325                 330                 335     


Lys Ser Ser Leu Arg Ser Arg Leu Tyr Asp Leu Tyr Pro Arg Arg Lys 
            340                 345                 350         


Glu Thr Thr Ser Asp Lys His Ser Glu Arg Thr Phe Val Ser Glu Thr 
        355                 360                 365             


Ala Asp Asp Ile Glu Lys Asn Gln Phe Tyr Gln Leu Pro Thr Pro Thr 
    370                 375                 380                 


Ser Ser Lys Asn Thr Arg Ile Gly Pro Phe Ala Asp Ala Ser Tyr Lys 
385                 390                 395                 400 


Glu Gly Glu Val Glu Pro Val Asp Met Tyr Thr Pro Asp Thr Ala Ala 
                405                 410                 415     


Asp Glu Glu Ala Arg Lys Phe Trp Thr Glu Asp Asn Asn Asn Leu 
            420                 425                 430     


<210>  164
<211>  382
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  sphingosine-1-phosphate receptor

<400>  164

Met Gly Pro Thr Ser Val Pro Leu Val Lys Ala His Arg Ser Ser Val 
1               5                   10                  15      


Ser Asp Tyr Val Asn Tyr Asp Ile Ile Val Arg His Tyr Asn Tyr Thr 
            20                  25                  30          


Gly Lys Leu Asn Ile Ser Ala Asp Lys Glu Asn Ser Ile Lys Leu Thr 
        35                  40                  45              


Ser Val Val Phe Ile Leu Ile Cys Cys Phe Ile Ile Leu Glu Asn Ile 
    50                  55                  60                  


Phe Val Leu Leu Thr Ile Trp Lys Thr Lys Lys Phe His Arg Pro Met 
65                  70                  75                  80  


Tyr Tyr Phe Ile Gly Asn Leu Ala Leu Ser Asp Leu Leu Ala Gly Val 
                85                  90                  95      


Ala Tyr Thr Ala Asn Leu Leu Leu Ser Gly Ala Thr Thr Tyr Lys Leu 
            100                 105                 110         


Thr Pro Ala Gln Trp Phe Leu Arg Glu Gly Ser Met Phe Val Ala Leu 
        115                 120                 125             


Ser Ala Ser Val Phe Ser Leu Leu Ala Ile Ala Ile Glu Arg Tyr Ile 
    130                 135                 140                 


Thr Met Leu Lys Met Lys Leu His Asn Gly Ser Asn Asn Phe Arg Leu 
145                 150                 155                 160 


Phe Leu Leu Ile Ser Ala Cys Trp Val Ile Ser Leu Ile Leu Gly Gly 
                165                 170                 175     


Leu Pro Ile Met Gly Trp Asn Cys Ile Ser Ala Leu Ser Ser Cys Ser 
            180                 185                 190         


Thr Val Leu Pro Leu Tyr His Lys His Tyr Ile Leu Phe Cys Thr Thr 
        195                 200                 205             


Val Phe Thr Leu Leu Leu Leu Ser Ile Val Ile Leu Tyr Cys Arg Ile 
    210                 215                 220                 


Tyr Ser Leu Val Arg Thr Arg Ser Arg Arg Leu Thr Phe Arg Lys Asn 
225                 230                 235                 240 


Ile Ser Lys Ala Ser Arg Ser Ser Glu Lys Ser Leu Ala Leu Leu Lys 
                245                 250                 255     


Thr Val Ile Ile Val Leu Ser Val Phe Ile Ala Cys Trp Ala Pro Leu 
            260                 265                 270         


Phe Ile Leu Leu Leu Leu Asp Val Gly Cys Lys Val Lys Thr Cys Asp 
        275                 280                 285             


Ile Leu Phe Arg Ala Glu Tyr Phe Leu Val Leu Ala Val Leu Asn Ser 
    290                 295                 300                 


Gly Thr Asn Pro Ile Ile Tyr Thr Leu Thr Asn Lys Glu Met Arg Arg 
305                 310                 315                 320 


Ala Phe Ile Arg Ile Met Ser Cys Cys Lys Cys Pro Ser Gly Asp Ser 
                325                 330                 335     


Ala Gly Lys Phe Lys Arg Pro Ile Ile Ala Gly Met Glu Phe Ser Arg 
            340                 345                 350         


Ser Lys Ser Asp Asn Ser Ser His Pro Gln Lys Asp Glu Gly Asp Asn 
        355                 360                 365             


Pro Glu Thr Ile Met Ser Ser Gly Asn Val Asn Ser Ser Ser 
    370                 375                 380         


<210>  165
<211>  593
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  parathyroid hormone receptor

<400>  165

Met Gly Thr Ala Arg Ile Ala Pro Gly Leu Ala Leu Leu Leu Cys Cys 
1               5                   10                  15      


Pro Val Leu Ser Ser Ala Tyr Ala Leu Val Asp Ala Asp Asp Val Met 
            20                  25                  30          


Thr Lys Glu Glu Gln Ile Phe Leu Leu His Arg Ala Gln Ala Gln Cys 
        35                  40                  45              


Glu Lys Arg Leu Lys Glu Val Leu Gln Arg Pro Ala Ser Ile Met Glu 
    50                  55                  60                  


Ser Asp Lys Gly Trp Thr Ser Ala Ser Thr Ser Gly Lys Pro Arg Lys 
65                  70                  75                  80  


Asp Lys Ala Ser Gly Lys Leu Tyr Pro Glu Ser Glu Glu Asp Lys Glu 
                85                  90                  95      


Ala Pro Thr Gly Ser Arg Tyr Arg Gly Arg Pro Cys Leu Pro Glu Trp 
            100                 105                 110         


Asp His Ile Leu Cys Trp Pro Leu Gly Ala Pro Gly Glu Val Val Ala 
        115                 120                 125             


Val Pro Cys Pro Asp Tyr Ile Tyr Asp Phe Asn His Lys Gly His Ala 
    130                 135                 140                 


Tyr Arg Arg Cys Asp Arg Asn Gly Ser Trp Glu Leu Val Pro Gly His 
145                 150                 155                 160 


Asn Arg Thr Trp Ala Asn Tyr Ser Glu Cys Val Lys Phe Leu Thr Asn 
                165                 170                 175     


Glu Thr Arg Glu Arg Glu Val Phe Asp Arg Leu Gly Met Ile Tyr Thr 
            180                 185                 190         


Val Gly Tyr Ser Val Ser Leu Ala Ser Leu Thr Val Ala Val Leu Ile 
        195                 200                 205             


Leu Ala Tyr Phe Arg Arg Leu His Cys Thr Arg Asn Tyr Ile His Met 
    210                 215                 220                 


His Leu Phe Leu Ser Phe Met Leu Arg Ala Val Ser Ile Phe Val Lys 
225                 230                 235                 240 


Asp Ala Val Leu Tyr Ser Gly Ala Thr Leu Asp Glu Ala Glu Arg Leu 
                245                 250                 255     


Thr Glu Glu Glu Leu Arg Ala Ile Ala Gln Ala Pro Pro Pro Pro Ala 
            260                 265                 270         


Thr Ala Ala Ala Gly Tyr Ala Gly Cys Arg Val Ala Val Thr Phe Phe 
        275                 280                 285             


Leu Tyr Phe Leu Ala Thr Asn Tyr Tyr Trp Ile Leu Val Glu Gly Leu 
    290                 295                 300                 


Tyr Leu His Ser Leu Ile Phe Met Ala Phe Phe Ser Glu Lys Lys Tyr 
305                 310                 315                 320 


Leu Trp Gly Phe Thr Val Phe Gly Trp Gly Leu Pro Ala Val Phe Val 
                325                 330                 335     


Ala Val Trp Val Ser Val Arg Ala Thr Leu Ala Asn Thr Gly Cys Trp 
            340                 345                 350         


Asp Leu Ser Ser Gly Asn Lys Lys Trp Ile Ile Gln Val Pro Ile Leu 
        355                 360                 365             


Ala Ser Ile Val Leu Asn Phe Ile Leu Phe Ile Asn Ile Val Arg Val 
    370                 375                 380                 


Leu Ala Thr Lys Leu Arg Glu Thr Asn Ala Gly Arg Cys Asp Thr Arg 
385                 390                 395                 400 


Gln Gln Tyr Arg Lys Leu Leu Lys Ser Thr Leu Val Leu Met Pro Leu 
                405                 410                 415     


Phe Gly Val His Tyr Ile Val Phe Met Ala Thr Pro Tyr Thr Glu Val 
            420                 425                 430         


Ser Gly Thr Leu Trp Gln Val Gln Met His Tyr Glu Met Leu Phe Asn 
        435                 440                 445             


Ser Phe Gln Gly Phe Phe Val Ala Ile Ile Tyr Cys Phe Cys Asn Gly 
    450                 455                 460                 


Glu Val Gln Ala Glu Ile Lys Lys Ser Trp Ser Arg Trp Thr Leu Ala 
465                 470                 475                 480 


Leu Asp Phe Lys Arg Lys Ala Arg Ser Gly Ser Ser Ser Tyr Ser Tyr 
                485                 490                 495     


Gly Pro Met Val Ser His Thr Ser Val Thr Asn Val Gly Pro Arg Val 
            500                 505                 510         


Gly Leu Gly Leu Pro Leu Ser Pro Arg Leu Leu Pro Thr Ala Thr Thr 
        515                 520                 525             


Asn Gly His Pro Gln Leu Pro Gly His Ala Lys Pro Gly Thr Pro Ala 
    530                 535                 540                 


Leu Glu Thr Leu Glu Thr Thr Pro Pro Ala Met Ala Ala Pro Lys Asp 
545                 550                 555                 560 


Asp Gly Phe Leu Asn Gly Ser Cys Ser Gly Leu Asp Glu Glu Ala Ser 
                565                 570                 575     


Gly Pro Glu Arg Pro Pro Ala Leu Leu Gln Glu Glu Trp Glu Thr Val 
            580                 585                 590         


Met 
    


<210>  166
<211>  348
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Asn Gly Thr Glu Gly Pro Asn Phe Tyr Val Pro Phe Ser Asn Ala 
1               5                   10                  15      


Thr Gly Val Val Arg Ser Pro Phe Glu Tyr Pro Gln Tyr Tyr Leu Ala 
            20                  25                  30          


Glu Pro Trp Gln Phe Ser Met Leu Ala Ala Tyr Met Phe Leu Leu Ile 
        35                  40                  45              


Val Leu Gly Phe Pro Ile Asn Phe Leu Thr Leu Tyr Val Thr Val Gln 
    50                  55                  60                  


His Lys Lys Leu Arg Thr Pro Leu Asn Tyr Ile Leu Leu Asn Leu Ala 
65                  70                  75                  80  


Val Ala Asp Leu Phe Met Val Leu Gly Gly Phe Thr Ser Thr Leu Tyr 
                85                  90                  95      


Thr Ser Leu His Gly Tyr Phe Val Phe Gly Pro Thr Gly Cys Asn Leu 
            100                 105                 110         


Glu Gly Phe Phe Ala Thr Leu Gly Gly Glu Ile Ala Leu Trp Ser Leu 
        115                 120                 125             


Val Val Leu Ala Ile Glu Arg Tyr Val Val Val Cys Lys Pro Met Ser 
    130                 135                 140                 


Asn Phe Arg Phe Gly Glu Asn His Ala Ile Met Gly Val Ala Phe Thr 
145                 150                 155                 160 


Trp Val Met Ala Leu Ala Cys Ala Ala Pro Pro Leu Ala Gly Trp Ser 
                165                 170                 175     


Arg Tyr Ile Pro Glu Gly Leu Gln Cys Ser Cys Gly Ile Asp Tyr Tyr 
            180                 185                 190         


Thr Leu Lys Pro Glu Val Asn Asn Glu Ser Phe Val Ile Tyr Met Phe 
        195                 200                 205             


Val Val His Phe Thr Ile Pro Met Ile Ile Ile Phe Phe Cys Tyr Gly 
    210                 215                 220                 


Gln Leu Val Phe Thr Val Lys Glu Ala Ala Ala Gln Gln Gln Glu Ser 
225                 230                 235                 240 


Ala Thr Thr Gln Lys Ala Glu Lys Glu Val Thr Arg Met Val Ile Ile 
                245                 250                 255     


Met Val Ile Ala Phe Leu Ile Cys Trp Val Pro Tyr Ala Ser Val Ala 
            260                 265                 270         


Phe Tyr Ile Phe Thr His Gln Gly Ser Asn Phe Gly Pro Ile Phe Met 
        275                 280                 285             


Thr Ile Pro Ala Phe Phe Ala Lys Ser Ala Ala Ile Tyr Asn Pro Val 
    290                 295                 300                 


Ile Tyr Ile Met Met Asn Lys Gln Phe Arg Asn Cys Met Leu Thr Thr 
305                 310                 315                 320 


Ile Cys Cys Gly Lys Asn Pro Leu Gly Asp Asp Glu Ala Ser Ala Thr 
                325                 330                 335     


Val Ser Lys Thr Glu Thr Ser Gln Val Ala Pro Ala 
            340                 345             


<210>  167
<211>  375
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<223>  estrogen receptor

<400>  167

Met Asp Val Thr Ser Gln Ala Arg Gly Val Gly Leu Glu Met Tyr Pro 
1               5                   10                  15      


Gly Thr Ala Gln Pro Ala Ala Pro Asn Thr Thr Ser Pro Glu Leu Asn 
            20                  25                  30          


Leu Ser His Pro Leu Leu Gly Thr Ala Leu Ala Asn Gly Thr Gly Glu 
        35                  40                  45              


Leu Ser Glu His Gln Gln Tyr Val Ile Gly Leu Phe Leu Ser Cys Leu 
    50                  55                  60                  


Tyr Thr Ile Phe Leu Phe Pro Ile Gly Phe Val Gly Asn Ile Leu Ile 
65                  70                  75                  80  


Leu Val Val Asn Ile Ser Phe Arg Glu Lys Met Thr Ile Pro Asp Leu 
                85                  90                  95      


Tyr Phe Ile Asn Leu Ala Val Ala Asp Leu Ile Leu Val Ala Asp Ser 
            100                 105                 110         


Leu Ile Glu Val Phe Asn Leu His Glu Arg Tyr Tyr Asp Ile Ala Val 
        115                 120                 125             


Leu Cys Thr Phe Met Ser Leu Phe Leu Gln Val Asn Met Tyr Ser Ser 
    130                 135                 140                 


Val Phe Phe Leu Thr Trp Met Ser Phe Asp Arg Tyr Ile Ala Leu Ala 
145                 150                 155                 160 


Arg Ala Met Arg Cys Ser Leu Phe Arg Thr Lys His His Ala Arg Leu 
                165                 170                 175     


Ser Cys Gly Leu Ile Trp Met Ala Ser Val Ser Ala Thr Leu Val Pro 
            180                 185                 190         


Phe Thr Ala Val His Leu Gln His Thr Asp Glu Ala Cys Phe Cys Phe 
        195                 200                 205             


Ala Asp Val Arg Glu Val Gln Trp Leu Glu Val Thr Leu Gly Phe Ile 
    210                 215                 220                 


Val Pro Phe Ala Ile Ile Gly Leu Cys Tyr Ser Leu Ile Val Arg Val 
225                 230                 235                 240 


Leu Val Arg Ala His Arg His Arg Gly Leu Arg Pro Arg Arg Gln Lys 
                245                 250                 255     


Ala Leu Arg Met Ile Leu Ala Val Val Leu Val Phe Phe Val Cys Trp 
            260                 265                 270         


Leu Pro Glu Asn Val Phe Ile Ser Val His Leu Leu Gln Arg Thr Gln 
        275                 280                 285             


Pro Gly Ala Ala Pro Cys Lys Gln Ser Phe Arg His Ala His Pro Leu 
    290                 295                 300                 


Thr Gly His Ile Val Asn Leu Ala Ala Phe Ser Asn Ser Cys Leu Asn 
305                 310                 315                 320 


Pro Leu Ile Tyr Ser Phe Leu Gly Glu Thr Phe Arg Asp Lys Leu Arg 
                325                 330                 335     


Leu Tyr Ile Glu Gln Lys Thr Asn Leu Pro Ala Leu Asn Arg Phe Cys 
            340                 345                 350         


His Ala Ala Leu Lys Ala Val Ile Pro Asp Ser Thr Glu Gln Ser Asp 
        355                 360                 365             


Val Arg Phe Ser Ser Ala Val 
    370                 375 


<210>  168
<211>  264
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Pro Ser Ile Phe Ala Tyr Gln Ser Ser Glu Val Asp Trp Cys Glu 
1               5                   10                  15      


Ser Asn Phe Gln Tyr Ser Glu Leu Val Ala Glu Phe Tyr Asn Thr Phe 
            20                  25                  30          


Ser Asn Ile Pro Phe Phe Ile Phe Gly Pro Leu Met Met Leu Leu Met 
        35                  40                  45              


His Pro Tyr Ala Gln Lys Arg Ser Arg Tyr Ile Tyr Val Val Trp Val 
    50                  55                  60                  


Leu Phe Met Ile Ile Gly Leu Phe Ser Met Tyr Phe His Met Thr Leu 
65                  70                  75                  80  


Ser Phe Leu Gly Gln Leu Leu Asp Glu Ile Ala Ile Leu Trp Leu Leu 
                85                  90                  95      


Gly Ser Gly Tyr Ser Ile Trp Met Pro Arg Cys Tyr Phe Pro Ser Phe 
            100                 105                 110         


Leu Gly Gly Asn Arg Ser Gln Phe Ile Arg Leu Val Phe Ile Thr Thr 
        115                 120                 125             


Val Val Ser Thr Leu Leu Ser Phe Leu Arg Pro Thr Val Asn Ala Tyr 
    130                 135                 140                 


Ala Leu Asn Ser Ile Ala Leu His Ile Leu Tyr Ile Val Cys Gln Glu 
145                 150                 155                 160 


Tyr Arg Lys Thr Ser Asn Lys Glu Leu Arg His Leu Ile Glu Val Ser 
                165                 170                 175     


Val Val Leu Trp Ala Val Ala Leu Thr Ser Trp Ile Ser Asp Arg Leu 
            180                 185                 190         


Leu Cys Ser Phe Trp Gln Arg Ile His Phe Phe Tyr Leu His Ser Ile 
        195                 200                 205             


Trp His Val Leu Ile Ser Ile Thr Phe Pro Tyr Gly Met Val Thr Met 
    210                 215                 220                 


Ala Leu Val Asp Ala Asn Tyr Glu Met Pro Gly Glu Thr Leu Lys Val 
225                 230                 235                 240 


Arg Tyr Trp Pro Arg Asp Ser Trp Pro Val Gly Leu Pro Tyr Val Glu 
                245                 250                 255     


Ile Arg Gly Asp Asp Lys Asp Cys 
            260                 


<210>  169
<211>  275
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Gly Ala Pro His Trp Trp Asp Gln Leu Gln Ala Gly Ser Ser Glu 
1               5                   10                  15      


Val Asp Trp Cys Glu Asp Asn Tyr Thr Ile Val Pro Ala Ile Ala Glu 
            20                  25                  30          


Phe Tyr Asn Thr Ile Ser Asn Val Leu Phe Phe Ile Leu Pro Pro Ile 
        35                  40                  45              


Cys Met Cys Leu Phe Arg Gln Tyr Ala Thr Cys Phe Asn Ser Gly Ile 
    50                  55                  60                  


Tyr Leu Ile Trp Thr Leu Leu Val Val Val Gly Ile Gly Ser Val Tyr 
65                  70                  75                  80  


Phe His Ala Thr Leu Ser Phe Leu Gly Gln Met Leu Asp Glu Leu Ala 
                85                  90                  95      


Val Leu Trp Val Leu Met Cys Ala Leu Ala Met Trp Phe Pro Arg Arg 
            100                 105                 110         


Tyr Leu Pro Lys Ile Phe Arg Asn Asp Arg Gly Arg Phe Lys Val Val 
        115                 120                 125             


Val Ser Val Leu Ser Ala Val Thr Thr Cys Leu Ala Phe Val Lys Pro 
    130                 135                 140                 


Ala Ile Asn Asn Ile Ser Leu Met Thr Leu Gly Val Pro Cys Thr Ala 
145                 150                 155                 160 


Leu Leu Ile Ala Glu Leu Lys Arg Cys Asp Asn Met Arg Val Phe Lys 
                165                 170                 175     


Leu Gly Leu Phe Ser Gly Leu Trp Trp Thr Leu Ala Leu Phe Cys Trp 
            180                 185                 190         


Ile Ser Asp Arg Ala Phe Cys Glu Leu Leu Ser Ser Phe Asn Phe Pro 
        195                 200                 205             


Tyr Leu His Cys Met Trp His Ile Leu Ile Cys Leu Ala Ala Tyr Leu 
    210                 215                 220                 


Gly Cys Val Cys Phe Ala Tyr Phe Asp Ala Ala Ser Glu Ile Pro Glu 
225                 230                 235                 240 


Gln Gly Pro Val Ile Lys Phe Trp Pro Ser Glu Lys Trp Ala Phe Ile 
                245                 250                 255     


Gly Val Pro Tyr Val Ser Leu Leu Cys Ala Asn Lys Lys Ser Ser Val 
            260                 265                 270         


Lys Thr Thr 
        275 


<210>  170
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ala Pro Ala Val Asp Arg Lys Gly Tyr Trp Gly Pro Thr Thr Ser 
1               5                   10                  15      


Thr Leu Asp Trp Cys Glu Glu Asn Tyr Ser Val Thr Trp Tyr Ile Ala 
            20                  25                  30          


Glu Phe Trp Asn Thr Val Ser Asn Leu Ile Met Ile Ile Pro Pro Met 
        35                  40                  45              


Phe Gly Ala Ile Gln Ser Val Arg Asp Gly Leu Glu Lys Arg Tyr Ile 
    50                  55                  60                  


Ala Ser Tyr Leu Ala Leu Thr Val Val Gly Met Gly Ser Trp Cys Phe 
65                  70                  75                  80  


His Met Thr Leu Lys Tyr Glu Met Gln Leu Leu Asp Glu Leu Pro Met 
                85                  90                  95      


Ile Tyr Ser Cys Cys Ile Phe Val Tyr Cys Met Phe Glu Cys Phe Lys 
            100                 105                 110         


Ile Lys Asn Ser Val Asn Tyr His Leu Leu Phe Thr Leu Val Leu Phe 
        115                 120                 125             


Ser Leu Ile Val Thr Thr Val Tyr Leu Lys Val Lys Glu Pro Ile Phe 
    130                 135                 140                 


His Gln Val Met Tyr Gly Met Leu Val Phe Thr Leu Val Leu Arg Ser 
145                 150                 155                 160 


Ile Tyr Ile Val Thr Trp Val Tyr Pro Trp Leu Arg Gly Leu Gly Tyr 
                165                 170                 175     


Thr Ser Leu Gly Ile Phe Leu Leu Gly Phe Leu Phe Trp Asn Ile Asp 
            180                 185                 190         


Asn Ile Phe Cys Glu Ser Leu Arg Asn Phe Arg Lys Lys Val Pro Pro 
        195                 200                 205             


Ile Ile Gly Ile Thr Thr Gln Phe His Ala Trp Trp His Ile Leu Thr 
    210                 215                 220                 


Gly Leu Gly Ser Tyr Leu His Ile Leu Phe Ser Leu Tyr Thr Arg Thr 
225                 230                 235                 240 


Leu Tyr Leu Arg Tyr Arg Pro Lys Val Lys Phe 
                245                 250     


<210>  171
<211>  275
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  171

Met Leu Phe Ser Trp Pro Tyr Pro Glu Ala Pro Ile Glu Gly Tyr Trp 
1               5                   10                  15      


Gly Lys Pro Thr Ser Leu Ile Asp Trp Cys Glu Glu Asn Tyr Val Val 
            20                  25                  30          


Ser Pro Tyr Ile Ala Glu Trp Ser Asn Thr Ile Thr Asn Ser Ile Phe 
        35                  40                  45              


Leu Met Thr Ala Phe Tyr Ser Thr Tyr Ser Ala Trp Arg Asn Lys Leu 
    50                  55                  60                  


Glu Thr Arg Tyr Ile Leu Ile Gly Met Gly Phe Ser Leu Val Gly Ile 
65                  70                  75                  80  


Gly Ser Trp Leu Phe His Met Thr Leu Gln Tyr Arg Tyr Gln Leu Leu 
                85                  90                  95      


Asp Glu Leu Pro Met Leu Tyr Ala Thr Ile Ile Pro Ser Trp Ser Ile 
            100                 105                 110         


Phe Ala Glu Thr Gln Glu Ile Leu Ile Lys Asp Glu Lys Lys Arg Lys 
        115                 120                 125             


Glu Ser Ser Phe Arg Ile Gln Met Val Ile Ser Phe Ile Met Cys Gly 
    130                 135                 140                 


Ile Val Thr Ile Leu Thr Trp Ile Tyr Val Val Val Gln Lys Pro Ala 
145                 150                 155                 160 


Ile Phe Gln Val Leu Tyr Gly Ile Leu Thr Leu Leu Val Val Val Leu 
                165                 170                 175     


Ser Gly Trp Leu Thr Tyr Tyr His Val His Asp Ser Phe Ala Lys Lys 
            180                 185                 190         


Asn Leu Phe Ile Thr Met Val Met Gly Met Ile Pro Phe Val Ile Gly 
        195                 200                 205             


Phe Ile Cys Trp Gln Leu Asp Ile His Leu Cys Ser Phe Trp Ile Tyr 
    210                 215                 220                 


Ile Arg Arg Thr Tyr Leu Ala Leu Pro Leu Gly Val Leu Leu Glu Leu 
225                 230                 235                 240 


His Ala Trp Trp His Leu Leu Thr Gly Thr Gly Val Tyr Ile Phe Val 
                245                 250                 255     


Val Tyr Leu Gln Tyr Leu Arg Ile Leu Thr His Gly Asn Pro Asn Asp 
            260                 265                 270         


Phe Leu Phe 
        275 


<210>  172
<211>  275
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  172

Met Gly Ile Phe Arg Trp Asn Tyr Pro Glu Ser Ser Val Pro Gly Val 
1               5                   10                  15      


Trp Gly Glu Thr Thr Ser Thr Ile Asp Trp Cys Glu Glu Asn Tyr Val 
            20                  25                  30          


Val Ser Pro Tyr Ile Ala Glu Trp Ser Asn Thr Leu Thr Asn Ser Val 
        35                  40                  45              


Phe Ile Leu Ser Ala Ile Tyr Thr Thr Tyr Ser Ala Tyr Lys Asn Lys 
    50                  55                  60                  


Leu Glu Lys Arg Phe Leu Leu Ile Gly Phe Gly Tyr Gly Leu Val Gly 
65                  70                  75                  80  


Val Gly Ser Trp Leu Phe His Met Thr Leu Lys Tyr Arg Phe Gln Leu 
                85                  90                  95      


Leu Asp Glu Leu Pro Met Ile Tyr Ala Met Cys Ile Pro Thr Trp Ser 
            100                 105                 110         


Leu Val Cys Glu Ala Lys Glu Ala Leu Leu Asn Gly Asp Asn His Lys 
        115                 120                 125             


Lys Val Pro Leu Phe Glu Gln Ile Phe Ile Gly Val Ile Ile Gly Leu 
    130                 135                 140                 


Ala Val Thr Thr Ala Ser Ile Leu Tyr Val Ile Tyr Lys Asn Val Asp 
145                 150                 155                 160 


Ile His Gln Ile Leu Phe Gly Val Gln Ile Val Val Val Ala Ala Thr 
                165                 170                 175     


Ala Gly Ser Leu Thr Tyr Arg Tyr Val His Asp Pro Leu Ala Lys Arg 
            180                 185                 190         


Asn Leu Lys Ala Ser Met Ala Leu Gly Ala Ile Leu Phe Leu Ser Gly 
        195                 200                 205             


Tyr Ile Ser Trp Leu Leu Asp Ile His Tyr Cys Ser Phe Trp Val His 
    210                 215                 220                 


Val Arg Arg Ser Ile Leu Ala Leu Pro Leu Gly Val Leu Leu Glu Pro 
225                 230                 235                 240 


His Gly Trp Trp His Ile Leu Thr Gly Met Gly Ile Tyr Phe Tyr Ile 
                245                 250                 255     


Val Ser Leu Glu His Leu Arg Val Ile Thr Leu Asn Val Ser Cys Asn 
            260                 265                 270         


Tyr Gln Phe 
        275 


