                               SEQUENCE LISTING

<110> GENENTECH, INC.
      Napoleon Ferrara
      Farbod Shojaei
      Xiumin Wu
      Cuiling Zhong
 
<120> INHIBITION OF ANGIOGENESIS

<130> GNE-0256PCT

<140> Not yet Assigned
<141> Herewith

<150> 60/974,382
<151> 2007-09-21

<150> 61/083,071
<151> 2008-07-23

<160> 37  

<170> PatentIn version 3.5

<210> 1
<211> 427
<212> DNA
<213> Homo sapiens

<400> 1
tgagggcgcc atgaggagcc tgtgctgcgc cccactcctg ctcctcttgc tgctgccgcc     60

gctgctgctc acgccccgcg ctggggacgc cgccgtgatc accggggctt gtgacaagga    120

ctcccaatgt ggtggaggca tgtgctgtgc tgtcagtatc tgggtcaaga gcataaggat    180

ttgcacacct atgggcaaac tgggagacag ctgccatcca ctgactcgta aaaacaattt    240

tggaaatgga aggcaggaaa gaagaaagag gaagagaagc aaaaggaaaa aggaggttcc    300

attttttggg cggaggatgc atcacacttg cccatgtctg ccaggcttgg cctgtttacg    360

gacttcattt aaccgattta tttgtttagc ccaaaagtaa tcgctctgga gtagaaacca    420

aatgtga                                                              427


<210> 2
<211> 129
<212> PRT
<213> Homo sapiens

<400> 2
Met Arg Ser Leu Cys Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Leu Thr Pro Arg Ala Gly Asp Ala Ala Val Ile Thr Gly 
            20                  25                  30          


Ala Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys Cys Ala Val 
        35                  40                  45              


Ser Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro Met Gly Lys Leu 
    50                  55                  60                  


Gly Asp Ser Cys His Pro Leu Thr Arg Lys Asn Asn Phe Gly Asn Gly 
65                  70                  75                  80  


Arg Gln Glu Arg Arg Lys Arg Lys Arg Ser Lys Arg Lys Lys Glu Val 
                85                  90                  95      


Pro Phe Phe Gly Arg Arg Met His His Thr Cys Pro Cys Leu Pro Gly 
            100                 105                 110         


Leu Ala Cys Leu Arg Thr Ser Phe Asn Arg Phe Ile Cys Leu Ala Gln 
        115                 120                 125             


Lys 
    


<210> 3
<211> 363
<212> DNA
<213> Homo sapiens

<400> 3
gagggcgcca tgaggagcct gtgctgcgcc ccactcctgc tcctcttgct gctgccgccg     60

ctgctgctca cgccccgcgc tggggacgcc gccgtgatca ccggggcttg tgacaaggac    120

tcccaatgtg gtggaggcat gtgctgtgct gtcagtatct gggtcaagag cataaggatt    180

tgcacaccta tgggcaaact gggagacagc tgccatccac tgactcgtaa agttccattt    240

tttgggcgga ggatgcatca cacttgccca tgtctgccag gcttggcctg tttacggact    300

tcatttaacc gatttatttg tttagcccaa aagtaatcgc tctggagtag aaaccaaatg    360

tga                                                                  363


<210> 4
<211> 108
<212> PRT
<213> Homo sapiens

<400> 4
Met Arg Ser Leu Cys Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Leu Thr Pro Arg Ala Gly Asp Ala Ala Val Ile Thr Gly 
            20                  25                  30          


Ala Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys Cys Ala Val 
        35                  40                  45              


Ser Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro Met Gly Lys Leu 
    50                  55                  60                  


Gly Asp Ser Cys His Pro Leu Thr Arg Lys Val Pro Phe Phe Gly Arg 
65                  70                  75                  80  


Arg Met His His Thr Cys Pro Cys Leu Pro Gly Leu Ala Cys Leu Arg 
                85                  90                  95      


Thr Ser Phe Asn Arg Phe Ile Cys Leu Ala Gln Lys 
            100                 105             


<210> 5
<211> 1338
<212> DNA
<213> Mus sp.

<400> 5
cggacgcgtg ggcgtcccct aaccgccacc gcgtccccgg gacgccatgg gggacccgcg     60

ctgtgccccg ctactgctac ttctgctgct accgctgctg ttcacaccgc ccgccgggga    120

tgccgcggtc atcaccgggg cttgcgacaa ggactctcag tgcggaggag gcatgtgctg    180

tgctgtcagt atctgggtta agagcataag gatctgcaca cctatgggcc aagtgggcga    240

cagctgccac cccctgactc ggaaagttcc attttggggg cggaggatgc accacacctg    300

cccctgcctg ccaggcttgg cgtgtttaag gacttctttc aaccggttta tttgcttggc    360

ccggaaatga tcactctgaa gtaggaactt gaaatgcgac cctccgctgc acaatgtccg    420

tcgagtctca cttgtaattg tggcaaacaa agaatactcc agaaagaaat gttctccccc    480

ttccttgact ttccaagtaa cgtttctatc tttgattttt gaagtggctt tttttttttt    540

ttttttttcc tttccttgaa ggaaagtttt gatttttgga gagatttata gaggactttc    600

tgacatggct tctcatttcc ctgtttatgt tttgccttga catttttgaa tgccaataac    660

aactgttttc acaaatagga gaataagagg gaacaatctg ttgcagaaac ttccttttgc    720

cctttgcccc actcgccccg ccccgccccg ccccgccctg cccatgcgca gacagacaca    780

cccttactct tcaaagactc tgatgatcct caccttactg tagcattgtg ggtttctaca    840

cttccccgcc ttgctggtgg acccactgag gaggctcaga gagctagcac tgtacaggtt    900

tgaaccagat cccccaagca gctcatttgg ggcagacgtt gggagcgctc caggaacttt    960

cctgcaccca tctggcccac tggctttcag ttctgctgtt taactggtgg gaggacaaaa   1020

ttaacgggac cctgaaggaa cctggcccgt ttatctagat ttgtttaagt aaaagacatt   1080

ttctccttgt tgtggaatat tacatgtctt tttctttttt atctgaagct tttttttttt   1140

ttctttaagt cttcttgttg gagacatttt aaagaacgcc actcgaggaa gcattgattt   1200

tcatytggca tgacaggagt catcatttta aaaaatcggt gttaagttat aatttaaact   1260

ttatttgtaa cccaaaggty taatgtaaat ggatttcctg atatcctgcc atttgtactg   1320

gtatcaatat ttytatgt                                                 1338


<210> 6
<211> 107
<212> PRT
<213> Mus sp.

<400> 6
Met Gly Asp Pro Arg Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Leu Leu Phe Thr Pro Pro Ala Gly Asp Ala Ala Val Ile Thr Gly Ala 
            20                  25                  30          


Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys Cys Ala Val Ser 
        35                  40                  45              


Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro Met Gly Gln Val Gly 
    50                  55                  60                  


Asp Ser Cys His Pro Leu Thr Arg Lys Val Pro Phe Trp Gly Arg Arg 
65                  70                  75                  80  


Met His His Thr Cys Pro Cys Leu Pro Gly Leu Ala Cys Leu Arg Thr 
                85                  90                  95      


Ser Phe Asn Arg Phe Ile Cys Leu Ala Arg Lys 
            100                 105         


<210> 7
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 7
gcatgacagg agtcatcatt tt                                              22


<210> 8
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 8
aaatggcagg atatcaggaa a                                               21


<210> 9
<211> 38
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe" 

<400> 9
aaactttatt tgtaacccaa aggtctaatg taaatgga                             38


<210> 10
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 10
atggcacgga agctagga                                                   18


<210> 11
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 11
gcagagctga agtcctcttg a                                               21


<210> 12
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe"  

<400> 12
tgctgctgga cccttcctaa acct                                            24


<210> 13
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 13
cagcgcacat gaagacttg                                                  19


<210> 14
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 14
gtcatcttcg gtttcctgag t                                               21


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe"  

<400> 15
tccaggcagc acccctgatg                                                 20


<210> 16
<211> 18
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 16
gaactccacg tgagcgca                                                   18


<210> 17
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 17
gggtcccatg ttgatgatgc                                                 20


<210> 18
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe"  

<400> 18
ctccctgata cacaccagcc cacctg                                          26


<210> 19
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 19
ctggaaggct tcttacaatg g                                               21


<210> 20
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 20
ggcatcccaa ttgtcttga                                                  19


<210> 21
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe"  

<400> 21
tccaggtctg cactggactt accg                                            24


<210> 22
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 22
tcaccatcgt tcgtgacttc                                                 20


<210> 23
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 23
agaaggcagt gaggtagtgc tt                                              22


<210> 24
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe"  

<400> 24
tccttcacga acacagtggg gaa                                             23


<210> 25
<211> 23
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 25
aggtcaaagg gaatgtgttc aaa                                             23


<210> 26
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 26
ccttgtctgc cttcagcttg t                                               21


<210> 27
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe"  

<400> 27
acaagcgcat cctcatggag cacatc                                          26


<210> 28
<211> 15
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 28
cgcaagcgcc gtgaa                                                      15


<210> 29
<211> 25
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 29
ggtctcttcc tccttggata aagtc                                           25


<210> 30
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe" 

<400> 30
ccaggccaag aaggaggaga tcatca                                          26


<210> 31
<211> 19
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 31
aatgacgagg gcctggagt                                                  19


<210> 32
<211> 21
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      primer" 

<400> 32
ttgatccgca taatctgcat g                                               21


<210> 33
<211> 26
<212> DNA
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      probe" 

<400> 33
tgtgcccact gaggagtcca acatca                                          26



<210> 34
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      peptide" 

<400> 34
Gly Ser Gly Ser 
1                      


<210> 35
<211> 4
<212> PRT
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      peptide" 

<400> 35
Gly Gly Gly Ser 
1                      


<210> 36
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> /note="Description of Artificial Sequence: Synthetic
      6x His tag" 

<400> 36
His His His His His His 
1               5       


<210> 37
<211> 130
<212> PRT
<213> Mus sp.

<400> 37
Met Gly Asp Pro Arg Cys Ala Pro Leu Leu Leu Leu Leu Leu Leu Pro 
1               5                   10                  15      


Pro Leu Leu Phe Thr Pro Arg Ala Gly Asp Ala Ala Val Ile Thr Gly 
            20                  25                  30          


Ala Cys Asp Lys Asp Ser Gln Cys Gly Gly Gly Met Cys Cys Ala Val 
        35                  40                  45              


Ser Ile Trp Val Lys Ser Ile Arg Ile Cys Thr Pro Met Gly Gln Val 
    50                  55                  60                  


Gly Asp Ser Cys His Pro Leu Thr Arg Lys Ser His Val Ala Asn Gly 
65                  70                  75                  80  


Arg Gln Glu Arg Arg Arg Ala Lys Arg Arg Lys Arg Lys Lys Glu Val 
                85                  90                  95      


Val Pro Phe Trp Gly Arg Arg Met His His Thr Cys Pro Cys Leu Pro 
            100                 105                 110         


Gly Leu Ala Cys Leu Arg Thr Ser Phe Asn Arg Phe Ile Cys Leu Ala 
        115                 120                 125             


Arg Lys 
    130 




