                         SEQUENCE LISTING

<110>  Ventana Medical Systems Inc.
 
<120>  PROSTATE CANCER BIOMARKERS

<130>  7668-81671-03

<150>  60/972,694
<151>  2007-09-14

<150>  61/054,925
<151>  2008-05-21

<160>  25    

<170>  PatentIn version 3.5

<210>  1
<211>  2828
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (411)..(1448)

<400>  1
agcagccggc acggggacag ccggccgcac aacggatctg caggcgcgga gcaaaatgca       60

cccgccgcgc cgcgcggtcc tgcagccccg ccacggcccc gcggcccgca cccccccggg      120

gcgacagtga gcctctcccg ccaccaccgg gggccgagcg gagggctctc gggtgggaga      180

gcgggaccag atctcgacag ctgttcattt ccaggaagcc accgcagcca gagcgaaagg      240

ggaccttctg ccaccagcgg ggcatcagcc agcggcgcgc atggatttat gaagacactc      300

atgcaagaag tgggcaggac ttggacaaac ttttccaccg gctccgcgtc cgccgctccc      360

cgcgcctcgt ctcctttccc ctcctctccc ggcggccgcc gctgcccgcg atg gtg         416
                                                       Met Val            
                                                       1                  

gcc gcg ctg ctg ggc ggc ggc ggc gag gcc cgc ggg ggg aca gtg ccg        464
Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr Val Pro           
        5                   10                  15                        

ggc gcc tgg ctg tgc ctg atg gcg ctg ctg cag ctg ctg ggc tcg gcg        512
Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly Ser Ala           
    20                  25                  30                            

ccg cgg gga tcg ggg ctg gcg cac ggc cgc cgc ctc atc tgc tgg cag        560
Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys Trp Gln           
35                  40                  45                  50            

gcg ctg ctg cag tgc cag ggg gag ccg gag tgc agc tac gcc tac aac        608
Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala Tyr Asn           
                55                  60                  65                

cag tac gcc gag gcg tgc gcg ccg gtg ctg gcg cag cac ggc ggg ggc        656
Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly Gly Gly           
            70                  75                  80                    

gac gcg ccc ggg gcc gcc gcc gcc gct ttc ccg gcc tcg gcc gcc tct        704
Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala Ala Ser           
        85                  90                  95                        

ttc tcg tcg cgc tgg cgc tgc ccg agt cac tgc atc tcg gcc ctc att        752
Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala Leu Ile           
    100                 105                 110                           

cag ctc aac cac acg cgc cgc ggg ccc gcc ctg gag gac tgt gac tgc        800
Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys Asp Cys           
115                 120                 125                 130           

gcg cag gac gag aac tgc aag tcc acc aag cgc gcc att gag ccg tgc        848
Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu Pro Cys           
                135                 140                 145               

ctg ccc cgg acg agc ggc ggc ggc gcg ggc ggc ccc ggc gcg ggc ggg        896
Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala Gly Gly           
            150                 155                 160                   

gtc atg ggc tgc acc gag gcc cgg cgg cgc tgc gac cgc gac agc cgc        944
Val Met Gly Cys Thr Glu Ala Arg Arg Arg Cys Asp Arg Asp Ser Arg           
        165                 170                 175                       

tgc aac ctg gcg ctg agc cgc tac ctg acc tac tgc ggc aaa gtc ttc        992
Cys Asn Leu Ala Leu Ser Arg Tyr Leu Thr Tyr Cys Gly Lys Val Phe           
    180                 185                 190                           

aac ggg ctg cgc tgc acg gac gaa tgc cgc acc gtc att gag gac atg       1040
Asn Gly Leu Arg Cys Thr Asp Glu Cys Arg Thr Val Ile Glu Asp Met           
195                 200                 205                 210           

ctg gct atg ccc aag gtg gcg ctg ctc aac gac tgc gtg tgc gac ggc       1088
Leu Ala Met Pro Lys Val Ala Leu Leu Asn Asp Cys Val Cys Asp Gly           
                215                 220                 225               

ctc gag cgg ccc atc tgc gag tcg gtc aag gag aac atg gcc cgc ctg       1136
Leu Glu Arg Pro Ile Cys Glu Ser Val Lys Glu Asn Met Ala Arg Leu           
            230                 235                 240                   

tgc ttc ggc gcc gag ctg ggc aac ggc ccc ggc agc agc ggc tcg gac       1184
Cys Phe Gly Ala Glu Leu Gly Asn Gly Pro Gly Ser Ser Gly Ser Asp           
        245                 250                 255                       

ggg ggc ctg gac gac tac tac gat gag gac tac gat gac gag cag cgc       1232
Gly Gly Leu Asp Asp Tyr Tyr Asp Glu Asp Tyr Asp Asp Glu Gln Arg           
    260                 265                 270                           

acc ggg ggc gcg ggt ggt gag cag ccg ctg gac gac gac gac ggc gtc       1280
Thr Gly Gly Ala Gly Gly Glu Gln Pro Leu Asp Asp Asp Asp Gly Val           
275                 280                 285                 290           

ccg cac cca ccg cgc ccg ggc agc ggc gct gct gca tcg ggc ggc cgc       1328
Pro His Pro Pro Arg Pro Gly Ser Gly Ala Ala Ala Ser Gly Gly Arg           
                295                 300                 305               

ggg gac ctg ccc tat ggg cct ggg cgc agg agc agc ggc ggc ggc ggc       1376
Gly Asp Leu Pro Tyr Gly Pro Gly Arg Arg Ser Ser Gly Gly Gly Gly           
            310                 315                 320                   

cgc ttg gcg ccc cgg ggc gcc tgg acc cca ctc gcc tcc atc ttg ctg       1424
Arg Leu Ala Pro Arg Gly Ala Trp Thr Pro Leu Ala Ser Ile Leu Leu           
        325                 330                 335                       

ctg ctg ctt ggg ccg ctc ttt tag ccctcgcgcc ccccgccgtt ggctgcggga      1478
Leu Leu Leu Gly Pro Leu Phe                                               
    340                 345                                               

gagcccgcgt cccactcccg tgctcgcctc gaccccgcgc cgggcacctg tggcttggga     1538

cagatagaag ggatggttgg ggatacttcc caaaactttt tccaagtcaa cttggtgtag     1598

ccggttcccc ggccacgact ctgggcactt cccctgaagc tcctctccgg agcttgactt     1658

cttggacctc ctcccccgcc ccaattccaa gctccagaaa ctcccaactc gtctgccgtc     1718

cagaaagcta gctgcagtgt tcaggacgtc cgggaggaag caagcatgtg ggggacagaa     1778

cagtagtcct ggactcgaaa gggaaggtgc tgaccagtgg ggccttagca atttgaaggg     1838

ttgggaagga ggaattatat ttgcaaaggg gctgtctatt agcatatttc ctttgagggg     1898

gcaaaaaaaa gtgccagtat cgacttttac agattgtggc cagtgaggat attataatcc     1958

tatgtaaaca gaaaagtccc acttaccgat tcattctttc actgtttgta tctgcgccca     2018

gaattctcag tgacgtgggg gtgagggtgg gtggcgattg ccttagaggg aacccctaaa     2078

ttggttttgg ataagtttga gcccttgacc ttaatttcat tgctaccact ctgatctctt     2138

agcacatttc ttaggattaa gggtccaaaa atgctgatct aaggggttgc catggtgttg     2198

aacaatgcaa ctttttattt aaaaaagctc tgcactgcca tgtatgaaag tctctttatg     2258

atgtttgttt ttttgtcatt tttgttcttt acatcaagaa attttatgtt taaatatgcg     2318

gagaatgtat attgcctctg ctcctatcag ggttgctaaa ccctggtaca tcgtatataa     2378

aatgtattaa aactggggtt tgttaccagt tgctgtactt tgtatataga atttttataa     2438

attgtatgct tcagaaataa tttattttta aaaagaaatt aaaagtttta aactcacatc     2498

catattacac ctttcccccc tgaaatgtat agaatccatt tgtcatcagg aatcaaaacc     2558

cacagtccat tgtgaagtgt gctatattta gaacagtctt aaaatgtaca gtgtatttta     2618

tagaattgaa gttaacattc ttattttcaa gagaatttat ggacgttgta gaaatgtaca     2678

aatgcatttc caaactgcct taaacgttgt atttttatag acatgttttt ttaaaaatcc     2738

taagttttta aataactatg gatttgtgta ttttttttgg ttatttgttt tattaaaaca     2798

tgtacatcag taaagagttt taaacaatga                                      2828


<210>  2
<211>  345
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Val Ala Ala Leu Leu Gly Gly Gly Gly Glu Ala Arg Gly Gly Thr 
1               5                   10                  15      


Val Pro Gly Ala Trp Leu Cys Leu Met Ala Leu Leu Gln Leu Leu Gly 
            20                  25                  30          


Ser Ala Pro Arg Gly Ser Gly Leu Ala His Gly Arg Arg Leu Ile Cys 
        35                  40                  45              


Trp Gln Ala Leu Leu Gln Cys Gln Gly Glu Pro Glu Cys Ser Tyr Ala 
    50                  55                  60                  


Tyr Asn Gln Tyr Ala Glu Ala Cys Ala Pro Val Leu Ala Gln His Gly 
65                  70                  75                  80  


Gly Gly Asp Ala Pro Gly Ala Ala Ala Ala Ala Phe Pro Ala Ser Ala 
                85                  90                  95      


Ala Ser Phe Ser Ser Arg Trp Arg Cys Pro Ser His Cys Ile Ser Ala 
            100                 105                 110         


Leu Ile Gln Leu Asn His Thr Arg Arg Gly Pro Ala Leu Glu Asp Cys 
        115                 120                 125             


Asp Cys Ala Gln Asp Glu Asn Cys Lys Ser Thr Lys Arg Ala Ile Glu 
    130                 135                 140                 


Pro Cys Leu Pro Arg Thr Ser Gly Gly Gly Ala Gly Gly Pro Gly Ala 
145                 150                 155                 160 


Gly Gly Val Met Gly Cys Thr Glu Ala Arg Arg Arg Cys Asp Arg Asp 
                165                 170                 175     


Ser Arg Cys Asn Leu Ala Leu Ser Arg Tyr Leu Thr Tyr Cys Gly Lys 
            180                 185                 190         


Val Phe Asn Gly Leu Arg Cys Thr Asp Glu Cys Arg Thr Val Ile Glu 
        195                 200                 205             


Asp Met Leu Ala Met Pro Lys Val Ala Leu Leu Asn Asp Cys Val Cys 
    210                 215                 220                 


Asp Gly Leu Glu Arg Pro Ile Cys Glu Ser Val Lys Glu Asn Met Ala 
225                 230                 235                 240 


Arg Leu Cys Phe Gly Ala Glu Leu Gly Asn Gly Pro Gly Ser Ser Gly 
                245                 250                 255     


Ser Asp Gly Gly Leu Asp Asp Tyr Tyr Asp Glu Asp Tyr Asp Asp Glu 
            260                 265                 270         


Gln Arg Thr Gly Gly Ala Gly Gly Glu Gln Pro Leu Asp Asp Asp Asp 
        275                 280                 285             


Gly Val Pro His Pro Pro Arg Pro Gly Ser Gly Ala Ala Ala Ser Gly 
    290                 295                 300                 


Gly Arg Gly Asp Leu Pro Tyr Gly Pro Gly Arg Arg Ser Ser Gly Gly 
305                 310                 315                 320 


Gly Gly Arg Leu Ala Pro Arg Gly Ala Trp Thr Pro Leu Ala Ser Ile 
                325                 330                 335     


Leu Leu Leu Leu Leu Gly Pro Leu Phe 
            340                 345 


<210>  3
<211>  5855
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (319)..(1461)

<400>  3
agttgcctgc gcgccctcgc cggaccggcg gctccctagt tgcgccccga ccaggccctg       60

cccttgctgc cggctcgcgc gcgtccgcgc cccctccatt cctgggcgca tcccagctct      120

gccccaactc gggagtccag gcccgggcgc cagtgcccgc ttcagctccg gttcactgcg      180

cccgccggac gcgcgccgga ggactccgca gccctgctcc tgaccgtccc cccaggctta      240

acccggtcgc tccgctcgga ttcctcggct gcgctcgctc gggtggcgac ttcctccccg      300

cgccccctcc ccctcgcc atg aag aag tcc att gga ata tta agc cca gga        351
                    Met Lys Lys Ser Ile Gly Ile Leu Ser Pro Gly           
                    1               5                   10                

gtt gct ttg ggg atg gct gga agt gca atg tct tcc aag ttc ttc cta        399
Val Ala Leu Gly Met Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu           
            15                  20                  25                    

gtg gct ttg gcc ata ttt ttc tcc ttc gcc cag gtt gta att gaa gcc        447
Val Ala Leu Ala Ile Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala           
        30                  35                  40                        

aat tct tgg tgg tcg cta ggt atg aat aac cct gtt cag atg tca gaa        495
Asn Ser Trp Trp Ser Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu           
    45                  50                  55                            

gta tat att ata gga gca cag cct ctc tgc agc caa ctg gca gga ctt        543
Val Tyr Ile Ile Gly Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu           
60                  65                  70                  75            

tct caa gga cag aag aaa ctg tgc cac ttg tat cag gac cac atg cag        591
Ser Gln Gly Gln Lys Lys Leu Cys His Leu Tyr Gln Asp His Met Gln           
                80                  85                  90                

tac atc gga gaa ggc gcg aag aca ggc atc aaa gaa tgc cag tat caa        639
Tyr Ile Gly Glu Gly Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln           
            95                  100                 105                   

ttc cga cat cga agg tgg aac tgc agc act gtg gat aac acc tct gtt        687
Phe Arg His Arg Arg Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val           
        110                 115                 120                       

ttt ggc agg gtg atg cag ata ggc agc cgc gag acg gcc ttc aca tac        735
Phe Gly Arg Val Met Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr           
    125                 130                 135                           

gcg gtg agc gca gca ggg gtg gtg aac gcc atg agc cgg gcg tgc cgc        783
Ala Val Ser Ala Ala Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg           
140                 145                 150                 155           

gag ggc gag ctg tcc acc tgc ggc tgc agc cgc gcc gcg cgc ccc aag        831
Glu Gly Glu Leu Ser Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys           
                160                 165                 170               

gac ctg ccg cgg gac tgg ctc tgg ggc ggc tgc ggc gac aac atc gac        879
Asp Leu Pro Arg Asp Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp           
            175                 180                 185                   

tat ggc tac cgc ttt gcc aag gag ttc gtg gac gcc cgc gag cgg gag        927
Tyr Gly Tyr Arg Phe Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu           
        190                 195                 200                       

cgc atc cac gcc aag ggc tcc tac gag agt gct cgc atc ctc atg aac        975
Arg Ile His Ala Lys Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn           
    205                 210                 215                           

ctg cac aac aac gag gcc ggc cgc agg acg gtg tac aac ctg gct gat       1023
Leu His Asn Asn Glu Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp           
220                 225                 230                 235           

gtg gcc tgc aag tgc cat ggg gtg tcc ggc tca tgt agc ctg aag aca       1071
Val Ala Cys Lys Cys His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr           
                240                 245                 250               

tgc tgg ctg cag ctg gca gac ttc cgc aag gtg ggt gat gcc ctg aag       1119
Cys Trp Leu Gln Leu Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys           
            255                 260                 265                   

gag aag tac gac agc gcg gcg gcc atg cgg ctc aac agc cgg ggc aag       1167
Glu Lys Tyr Asp Ser Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys           
        270                 275                 280                       

ttg gta cag gtc aac agc cgc ttc aac tcg ccc acc aca caa gac ctg       1215
Leu Val Gln Val Asn Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu           
    285                 290                 295                           

gtc tac atc gac ccc agc cct gac tac tgc gtg cgc aat gag agc acc       1263
Val Tyr Ile Asp Pro Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr           
300                 305                 310                 315           

ggc tcg ctg ggc acg cag ggc cgc ctg tgc aac aag acg tcg gag ggc       1311
Gly Ser Leu Gly Thr Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly           
                320                 325                 330               

atg gat ggc tgc gag ctc atg tgc tgc ggc cgt ggc tac gac cag ttc       1359
Met Asp Gly Cys Glu Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe           
            335                 340                 345                   

aag acc gtg cag acg gag cgc tgc cac tgc aag ttc cac tgg tgc tgc       1407
Lys Thr Val Gln Thr Glu Arg Cys His Cys Lys Phe His Trp Cys Cys           
        350                 355                 360                       

tac gtc aag tgc aag aag tgc acg gag atc gtg gac cag ttt gtg tgc       1455
Tyr Val Lys Cys Lys Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys           
    365                 370                 375                           

aag tag tgggtgccac ccagcactca gccccgctcc caggacccgc ttatttatag        1511
Lys                                                                       
380                                                                       

aaagtacagt gattctggtt tttggttttt agaaatattt tttatttttc cccaagaatt     1571

gcaaccggaa ccattttttt tcctgttacc atctaagaac tctgtggttt attattaata     1631

ttataattat tatttggcaa taatgggggt gggaaccaag aaaaatattt attttgtgga     1691

tctttgaaaa ggtaatacaa gacttctttt gatagtatag aatgaagggg aaataacaca     1751

taccctaact tagctgtgtg gacatggtac acatccagaa ggtaaagaaa tacattttct     1811

ttttctcaaa tatgccatca tatgggatgg gtaggttcca gttgaaagag ggtggtagaa     1871

atctattcac aattcagctt ctatgaccaa aatgagttgt aaattctctg gtgcaagata     1931

aaaggtcttg ggaaaacaaa acaaaacaaa acaaacctcc cttccccagc agggctgcta     1991

gcttgctttc tgcattttca aaatgataat ttacaatgga aggacaagaa tgtcatattc     2051

tcaaggaaaa aaggtatatc acatgtctca ttctcctcaa atattccatt tgcagacaga     2111

ccgtcatatt ctaatagctc atgaaatttg ggcagcaggg aggaaagtcc ccagaaatta     2171

aaaaatttaa aactcttatg tcaagatgtt gatttgaagc tgttataaga attaggattc     2231

cagattgtaa aaagatcccc aaatgattct ggacactaga tttttttgtt tggggaggtt     2291

ggcttgaaca taaatgaaaa tatcctgtta ttttcttagg gatacttggt tagtaaatta     2351

taatagtaaa aataatacat gaatcccatt cacaggttct cagcccaagc aacaaggtaa     2411

ttgcgtgcca ttcagcactg caccagagca gacaacctat ttgaggaaaa acagtgaaat     2471

ccaccttcct cttcacactg agccctctct gattcctccg tgttgtgatg tgatgctggc     2531

cacgtttcca aacggcagct ccactgggtc ccctttggtt gtaggacagg aaatgaaaca     2591

ttaggagctc tgcttggaaa acagttcact acttagggat ttttgtttcc taaaactttt     2651

attttgagga gcagtagttt tctatgtttt aatgacagaa cttggctaat ggaattcaca     2711

gaggtgttgc agcgtatcac tgttatgatc ctgtgtttag attatccact catgcttctc     2771

ctattgtact gcaggtgtac cttaaaactg ttcccagtgt acttgaacag ttgcatttat     2831

aaggggggaa atgtggttta atggtgcctg atatctcaaa gtcttttgta cataacatat     2891

atatatatat acatatatat aaatataaat ataaatatat ctcattgcag ccagtgattt     2951

agatttacag tttactctgg ggttatttct ctgtctagag cattgttgtc cttcactgca     3011

gtccagttgg gattattcca aaagtttttt gagtcttgag cttgggctgt ggccctgctg     3071

tgatcatacc ttgagcacga cgaagcaacc ttgtttctga ggaagcttga gttctgactc     3131

actgaaatgc gtgttgggtt gaagatatct tttttctttt ctgcctcacc cctttgtctc     3191

caacctccat ttctgttcac tttgtggaga gggcattact tgttcgttat agacatggac     3251

gttaagagat attcaaaact cagaagcatc agcaatgttt ctcttttctt agttcattct     3311

gcagaatgga aacccatgcc tattagaaat gacagtactt attaattgag tccctaagga     3371

atattcagcc cactacatag atagcttttt tttttttttt tttaataagg acacctcttt     3431

ccaaacagtg ccatcaaata tgttcttatc tcagacttac gttgttttaa aagtttggaa     3491

agatacacat ctttcatacc ccccttaggc aggttggctt tcatatcacc tcagccaact     3551

gtggctctta atttattgca taatgatatt cacatcccct cagttgcagt gaattgtgag     3611

caaaagatct tgaaagcaaa aagcactaat tagtttaaaa tgtcactttt ttggttttta     3671

ttatacaaaa accatgaagt acttttttta tttgctaaat cagattgttc ctttttagtg     3731

actcatgttt atgaagagag ttgagtttaa caatcctagc ttttaaaaga aactatttaa     3791

tgtaaaatat tctacatgtc attcagatat tatgtatatc ttctagcctt tattctgtac     3851

ttttaatgta catatttctg tcttgcgtga tttgtatatt tcactggttt aaaaaacaaa     3911

catcgaaagg cttatgccaa atggaagata gaatataaaa taaaacgtta cttgtatatt     3971

ggtaagtggt ttcaattgtc cttcagataa ttcatgtgga gatttttgga gaaaccatga     4031

cggatagttt aggatgacta catgtcaaag taataaaaga gtggtgaatt ttaccaaaac     4091

caagctattt ggaagcttca aaaggtttct atatgtaatg gaacaaaagg ggaattctct     4151

tttcctatat atgttcctta caaaaaaaaa aaaaaaagaa atcaagcaga tggcttaaag     4211

ctggttatag gattgctcac attcttttag cattatgcat gtaacttaat tgttttagag     4271

cgtgttgctg ttgtaacatc ccagagaaga atgaaaaggc acatgctttt atccgtgacc     4331

agatttttag tccaaaaaaa tgtatttttt tgtgtgttta ccactgcaac tattgcacct     4391

ctctatttga atttactgtg gaccatgtgt ggtgtctcta tgccctttga aagcagtttt     4451

tataaaaaga aagcccgggt ctgcagagaa tgaaaactgg ttggaaacta aaggttcatt     4511

gtgttaagtg caattaatac aagttattgt gcttttcaaa aatgtacacg gaaatctgga     4571

cagtgctgca cagattgata cattagcctt tgctttttct ctttccggat aaccttgtaa     4631

catattgaaa ccttttaagg atgccaagaa tgcattattc cacaaaaaaa cagcagacca     4691

acatatagag tgtttaaaat agcatttctg ggcaaattca aactcttgtg gttctaggac     4751

tcacatctgt ttcagttttt cctcagttgt atattgacca gtgttcttta ttgcaaaaac     4811

atatacccga tttagcagtg tcagcgtatt ttttcttctc atcctggagc gtattcaaga     4871

tcttcccaat acaagaaaat taataaaaaa tttatatata ggcagcagca aaagagccat     4931

gttcaaaata gtcattatgg gctcaaatag aaagaagact tttaagtttt aatccagttt     4991

atctgttgag ttctgtgagc tactgacctc ctgagactgg cactgtgtaa gttttagttg     5051

cctaccctag ctcttttctc gtacaatttt gccaatacca agtttcaatt tgtttttaca     5111

aaacattatt caagccacta gaattatcaa atatgacgct atagcagagt aaatactctg     5171

aataagagac cggtactagc taactccaag agatcgttag cagcatcagt ccacaaacac     5231

ttagtggccc acaatatata gagagataga aaaggtagtt ataacttgaa gcatgtattt     5291

aatgcaaata ggcacgaagg cacaggtcta aaatactaca ttgtcactgt aagctatact     5351

tttaaaatat ttattttttt taaagtattt tctagtcttt tctctctctg tggaatggtg     5411

aaagagagat gccgtgtttt gaaagtaaga tgatgaaatg aatttttaat tcaagaaaca     5471

ttcagaaaca taggaattaa aacttagaga aatgatctaa tttccctgtt cacacaaact     5531

ttacacttta atctgatgat tggatatttt attttagtga aacatcatct tgttagctaa     5591

ctttaaaaaa tggatgtaga atgattaaag gttggtatga ttttttttta atgtatcagt     5651

ttgaacctag aatattgaat taaaatgctg tctcagtatt ttaaaagcaa aaaaggaatg     5711

gaggaaaatt gcatcttaga ccatttttat atgcagtgta caatttgctg ggctagaaat     5771

gagataaaga ttatttattt ttgttcatat cttgtacttt tctattaaaa tcattttatg     5831

aaatccaaaa aaaaaaaaaa aaaa                                            5855


<210>  4
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Lys Ser Ile Gly Ile Leu Ser Pro Gly Val Ala Leu Gly Met 
1               5                   10                  15      


Ala Gly Ser Ala Met Ser Ser Lys Phe Phe Leu Val Ala Leu Ala Ile 
            20                  25                  30          


Phe Phe Ser Phe Ala Gln Val Val Ile Glu Ala Asn Ser Trp Trp Ser 
        35                  40                  45              


Leu Gly Met Asn Asn Pro Val Gln Met Ser Glu Val Tyr Ile Ile Gly 
    50                  55                  60                  


Ala Gln Pro Leu Cys Ser Gln Leu Ala Gly Leu Ser Gln Gly Gln Lys 
65                  70                  75                  80  


Lys Leu Cys His Leu Tyr Gln Asp His Met Gln Tyr Ile Gly Glu Gly 
                85                  90                  95      


Ala Lys Thr Gly Ile Lys Glu Cys Gln Tyr Gln Phe Arg His Arg Arg 
            100                 105                 110         


Trp Asn Cys Ser Thr Val Asp Asn Thr Ser Val Phe Gly Arg Val Met 
        115                 120                 125             


Gln Ile Gly Ser Arg Glu Thr Ala Phe Thr Tyr Ala Val Ser Ala Ala 
    130                 135                 140                 


Gly Val Val Asn Ala Met Ser Arg Ala Cys Arg Glu Gly Glu Leu Ser 
145                 150                 155                 160 


Thr Cys Gly Cys Ser Arg Ala Ala Arg Pro Lys Asp Leu Pro Arg Asp 
                165                 170                 175     


Trp Leu Trp Gly Gly Cys Gly Asp Asn Ile Asp Tyr Gly Tyr Arg Phe 
            180                 185                 190         


Ala Lys Glu Phe Val Asp Ala Arg Glu Arg Glu Arg Ile His Ala Lys 
        195                 200                 205             


Gly Ser Tyr Glu Ser Ala Arg Ile Leu Met Asn Leu His Asn Asn Glu 
    210                 215                 220                 


Ala Gly Arg Arg Thr Val Tyr Asn Leu Ala Asp Val Ala Cys Lys Cys 
225                 230                 235                 240 


His Gly Val Ser Gly Ser Cys Ser Leu Lys Thr Cys Trp Leu Gln Leu 
                245                 250                 255     


Ala Asp Phe Arg Lys Val Gly Asp Ala Leu Lys Glu Lys Tyr Asp Ser 
            260                 265                 270         


Ala Ala Ala Met Arg Leu Asn Ser Arg Gly Lys Leu Val Gln Val Asn 
        275                 280                 285             


Ser Arg Phe Asn Ser Pro Thr Thr Gln Asp Leu Val Tyr Ile Asp Pro 
    290                 295                 300                 


Ser Pro Asp Tyr Cys Val Arg Asn Glu Ser Thr Gly Ser Leu Gly Thr 
305                 310                 315                 320 


Gln Gly Arg Leu Cys Asn Lys Thr Ser Glu Gly Met Asp Gly Cys Glu 
                325                 330                 335     


Leu Met Cys Cys Gly Arg Gly Tyr Asp Gln Phe Lys Thr Val Gln Thr 
            340                 345                 350         


Glu Arg Cys His Cys Lys Phe His Trp Cys Cys Tyr Val Lys Cys Lys 
        355                 360                 365             


Lys Cys Thr Glu Ile Val Asp Gln Phe Val Cys Lys 
    370                 375                 380 


<210>  5
<211>  1598
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (85)..(915)

<400>  5
gcgcacgtcc cggattcctc ccacgagggg gcgggctgcg gccaaatctc ccgccaggtc       60

agcggccggg cgctgattgg cccc atg gcg gcg ggg ccg gct cgt gat tgg         111
                           Met Ala Ala Gly Pro Ala Arg Asp Trp            
                           1               5                              

cca gca cgc cgt ggt tta aag cgg tcg gcg cgg gaa cca ggg gct tac        159
Pro Ala Arg Arg Gly Leu Lys Arg Ser Ala Arg Glu Pro Gly Ala Tyr           
10                  15                  20                  25            

tgc ggg acg gcc ttg gag agt act cgg gtt cgt gaa ctt ccc gga ggc        207
Cys Gly Thr Ala Leu Glu Ser Thr Arg Val Arg Glu Leu Pro Gly Gly           
                30                  35                  40                

gca atg agc tgc att aac ctg ccc act gtg ctg cct ggc tcc ccc agc        255
Ala Met Ser Cys Ile Asn Leu Pro Thr Val Leu Pro Gly Ser Pro Ser           
            45                  50                  55                    

aag acc cgg ggg cag atc cag gtg att ctc ggg ccg atg ttc tca gga        303
Lys Thr Arg Gly Gln Ile Gln Val Ile Leu Gly Pro Met Phe Ser Gly           
        60                  65                  70                        

aaa agc aca gag ttg atg aga cgc gtc cgt cgc ttc cag att gct cag        351
Lys Ser Thr Glu Leu Met Arg Arg Val Arg Arg Phe Gln Ile Ala Gln           
    75                  80                  85                            

tac aag tgc ctg gtg atc aag tat gcc aaa gac act cgc tac agc agc        399
Tyr Lys Cys Leu Val Ile Lys Tyr Ala Lys Asp Thr Arg Tyr Ser Ser           
90                  95                  100                 105           

agc ttc tgc aca cat gac cgg aac acc atg gag gca ctg ccc gcc tgc        447
Ser Phe Cys Thr His Asp Arg Asn Thr Met Glu Ala Leu Pro Ala Cys           
                110                 115                 120               

ctg ctc cga gac gtg gcc cag gag gcc ctg ggc gtg gct gtc ata ggc        495
Leu Leu Arg Asp Val Ala Gln Glu Ala Leu Gly Val Ala Val Ile Gly           
            125                 130                 135                   

atc gac gag ggg cag ttt ttc cct gac atc gtg gag ttc tgc gag gcc        543
Ile Asp Glu Gly Gln Phe Phe Pro Asp Ile Val Glu Phe Cys Glu Ala           
        140                 145                 150                       

atg gcc aac gcc ggg aag acc gta att gtg gct gca ctg gat ggg acc        591
Met Ala Asn Ala Gly Lys Thr Val Ile Val Ala Ala Leu Asp Gly Thr           
    155                 160                 165                           

ttc cag agg aag cca ttt ggg gcc atc ctg aac ctg gtg ccg ctg gcc        639
Phe Gln Arg Lys Pro Phe Gly Ala Ile Leu Asn Leu Val Pro Leu Ala           
170                 175                 180                 185           

gag agc gtg gtg aag ctg acg gcg gtg tgc atg gag tgc ttc cgg gaa        687
Glu Ser Val Val Lys Leu Thr Ala Val Cys Met Glu Cys Phe Arg Glu           
                190                 195                 200               

gcc gcc tat acc aag agg ctc ggc aca gag aag gag gtc gag gtg att        735
Ala Ala Tyr Thr Lys Arg Leu Gly Thr Glu Lys Glu Val Glu Val Ile           
            205                 210                 215                   

ggg gga gca gac aag tac cac tcc gtg tgt cgg ctc tgc tac ttc aag        783
Gly Gly Ala Asp Lys Tyr His Ser Val Cys Arg Leu Cys Tyr Phe Lys           
        220                 225                 230                       

aag gcc tca ggc cag cct gcc ggg ccg gac aac aaa gag aac tgc cca        831
Lys Ala Ser Gly Gln Pro Ala Gly Pro Asp Asn Lys Glu Asn Cys Pro           
    235                 240                 245                           

gtg cca gga aag cca ggg gaa gcc gtg gct gcc agg aag ctc ttt gcc        879
Val Pro Gly Lys Pro Gly Glu Ala Val Ala Ala Arg Lys Leu Phe Ala           
250                 255                 260                 265           

cca cag cag att ctg caa tgc agc cct gcc aac tga gggacctgcg             925
Pro Gln Gln Ile Leu Gln Cys Ser Pro Ala Asn                               
                270                 275                                   

agggccgccc gctcccttcc tgccactgcc gcctactgga cgctgccctg catgctgccc      985

agccactcca ggaggaagtc gggaggcgtg gagggtgacc acaccttggc cttctgggaa     1045

ctctcctttg tgtggctgcc ccacctgccg catgctccct cctctcctac ccactggtct     1105

gcttaaagct tccctctcag ctgctgggac gatcgcccag gctggagctg gccccgcttg     1165

gtggcctggg atctggcaca ctccctctcc ttggggtgag ggacagagcc ccacgctgtt     1225

gacatcagcc tgcttcttcc cctctgcggc tttcactgct gagtttctgt tctccctggg     1285

aagcctgtgc cagcaccttt gagccttggc ccacactgag gcttaggcct ctctgcctgg     1345

gatgggctcc caccctcccc tgaggatggc ctggattcac gccctcttgt ttccttttgg     1405

gctcaaagcc cttcctacct ctggtgatgg tttccacagg aacaacagca tctttcacca     1465

agatgggtgg caccaacctt gctgggactt ggatcccagg ggcttatctc ttcaagtgtg     1525

gagagggcag ggtccacgcc tctgctgtag cttatgaaat taactaattg aaaattcact     1585

ggttggtgga aaa                                                        1598


<210>  6
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ala Ala Gly Pro Ala Arg Asp Trp Pro Ala Arg Arg Gly Leu Lys 
1               5                   10                  15      


Arg Ser Ala Arg Glu Pro Gly Ala Tyr Cys Gly Thr Ala Leu Glu Ser 
            20                  25                  30          


Thr Arg Val Arg Glu Leu Pro Gly Gly Ala Met Ser Cys Ile Asn Leu 
        35                  40                  45              


Pro Thr Val Leu Pro Gly Ser Pro Ser Lys Thr Arg Gly Gln Ile Gln 
    50                  55                  60                  


Val Ile Leu Gly Pro Met Phe Ser Gly Lys Ser Thr Glu Leu Met Arg 
65                  70                  75                  80  


Arg Val Arg Arg Phe Gln Ile Ala Gln Tyr Lys Cys Leu Val Ile Lys 
                85                  90                  95      


Tyr Ala Lys Asp Thr Arg Tyr Ser Ser Ser Phe Cys Thr His Asp Arg 
            100                 105                 110         


Asn Thr Met Glu Ala Leu Pro Ala Cys Leu Leu Arg Asp Val Ala Gln 
        115                 120                 125             


Glu Ala Leu Gly Val Ala Val Ile Gly Ile Asp Glu Gly Gln Phe Phe 
    130                 135                 140                 


Pro Asp Ile Val Glu Phe Cys Glu Ala Met Ala Asn Ala Gly Lys Thr 
145                 150                 155                 160 


Val Ile Val Ala Ala Leu Asp Gly Thr Phe Gln Arg Lys Pro Phe Gly 
                165                 170                 175     


Ala Ile Leu Asn Leu Val Pro Leu Ala Glu Ser Val Val Lys Leu Thr 
            180                 185                 190         


Ala Val Cys Met Glu Cys Phe Arg Glu Ala Ala Tyr Thr Lys Arg Leu 
        195                 200                 205             


Gly Thr Glu Lys Glu Val Glu Val Ile Gly Gly Ala Asp Lys Tyr His 
    210                 215                 220                 


Ser Val Cys Arg Leu Cys Tyr Phe Lys Lys Ala Ser Gly Gln Pro Ala 
225                 230                 235                 240 


Gly Pro Asp Asn Lys Glu Asn Cys Pro Val Pro Gly Lys Pro Gly Glu 
                245                 250                 255     


Ala Val Ala Ala Arg Lys Leu Phe Ala Pro Gln Gln Ile Leu Gln Cys 
            260                 265                 270         


Ser Pro Ala Asn 
        275     


<210>  7
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  forward primer for qRT PCR assay of RPL13a

<400>  7
gtacgctgtg aaggcatcaa                                                   20


<210>  8
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  reverse primer for qRT PCR assay of RPL13a

<400>  8
gttggtgttc atccgcttg                                                    19


<210>  9
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  9
ggcgattgcc ttagagggaa cccctaaatt ggttttggat aagtt                       45


<210>  10
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  10
tgggacagat agaagggatg gttggggata cttcccaaaa ctttttc                     47


<210>  11
<211>  42
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  11
gtggagaggg cagggtccac gcctctgctg tacttatgaa at                          42


<210>  12
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  12
ctggtgatgg tttccacagg aacaacagca tctttcacca agat                        44


<210>  13
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  13
agttgatgag acgcgtccgt cgcttccaga ttgctcagta caa                         43


<210>  14
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  14
cactgggtcc cctttggttg taggacagga aatgaaacat agga                        44


<210>  15
<211>  45
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  15
ccatattttt ctccttcgcc caggttgtaa ttgaagccaa ttctt                       45


<210>  16
<211>  44
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  16
ggaggagaag cgcagtcaat caacagtaaa cttaagagac cccc                        44


<210>  17
<211>  47
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Illumina probe

<400>  17
tgggacagat agaagggatg gttggggata cttcccaaaa ctttttc                     47


<210>  18
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WNT5A primer

<400>  18
gtgcaatgtc ttccaagttc ttc                                               23


<210>  19
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WNT5A primer

<400>  19
ggcacagttt cttctgtcct tg                                                22


<210>  20
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WNT5A primer

<400>  20
ggctggaagt gcaatgtctt cc                                                22


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  WNT5A primer

<400>  21
gcctgtcttc gcgccttctc c                                                 21


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TK1 primer

<400>  22
cgccgggaag accgtaat                                                     18


<210>  23
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  TK1 primer

<400>  23
tcaggatggc cccaaatg                                                     18


<210>  24
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAS1 primer

<400>  24
aatacattgc tcaccaggaa cc                                                22


<210>  25
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  GAS1 primer

<400>  25
gtttaaggca gtttggaaat gc                                                22


