                         SEQUENCE LISTING

<110>  NovelMed Therapeutics, Inc.
 
<120>  Method of inhibiting complement activation with Factor Bb 
       specific antibodies and use thereof

<130>  NMT-8772 WO ORD

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  1

Thr Pro Trp Ser Leu Ala Trp Pro Gln Gly Ser Cys Ser Leu Glu Gly 
1               5                   10                  15      


Val Glu Ile Lys Gly Gly Ser Phe Arg Leu Leu Gln Glu Gly Gln Ala 
            20                  25                  30          


Leu Glu Tyr Val Cys Pro Ser Gly Phe Tyr Pro Tyr Pro Val Gln Thr 
        35                  40                  45              


Arg Thr Cys Arg Ser Thr Gly Ser Trp Ser Thr Leu Lys Thr Gln Asp 
    50                  55                  60                  


Gln Lys Thr Val Arg Lys Ala Glu Cys Arg Ala Ile His Cys Pro Arg 
65                  70                  75                  80  


Pro His Asp Phe Glu Asn Gly Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr 
                85                  90                  95      


Asn Val Ser Asp Glu Ile Ser Phe His Cys Tyr Asp Gly Tyr Thr Leu 
            100                 105                 110         


Arg Gly Ser Ala Asn Arg Thr Cys Gln Val Asn Gly Arg Trp Ser Gly 
        115                 120                 125             


Gln Thr Ala Ile Cys Asp Asn Gly Ala Gly Tyr Cys Ser Asn Pro Gly 
    130                 135                 140                 


Ile Pro Ile Gly Thr Arg Lys Val Gly Ser Gln Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Ser Val Thr Tyr His Cys Ser Arg Gly Leu Thr Leu Arg Gly Ser Gln 
                165                 170                 175     


Arg Arg Thr Cys Gln Glu Gly Gly Ser Trp Ser Gly Thr Glu Pro Ser 
            180                 185                 190         


Cys Gln Asp Ser Phe Met Tyr Asp Thr Pro Gln Glu Val Ala Glu Ala 
        195                 200                 205             


Phe Leu Ser Ser Leu Thr Glu Thr Ile Glu Gly Val Asp Ala Glu Asp 
    210                 215                 220                 


Gly His Gly Pro Gly Glu Gln Gln Lys Arg Lys Ile Val Leu Asp Pro 
225                 230                 235                 240 


Ser Gly Ser Met Asn Ile Tyr Leu Val Leu Asp Gly Ser Asp Ser Ile 
                245                 250                 255     


Gly Ala Ser Asn Phe Thr Gly Ala Lys Lys Cys Leu Val Asn Leu Ile 
            260                 265                 270         


Glu Lys Val Ala Ser Tyr Gly Val Lys Pro Arg Tyr Gly Leu Val Thr 
        275                 280                 285             


Tyr Ala Thr Tyr Pro Lys Ile Trp Val Lys Val Ser Glu Ala Asp Ser 
    290                 295                 300                 


Ser Asn Ala Asp Trp Val Thr Lys Gln Leu Asn Glu Ile Asn Tyr Glu 
305                 310                 315                 320 


Asp His Lys Leu Lys Ser Gly Thr Asn Thr Lys Lys Ala Leu Gln Ala 
                325                 330                 335     


Val Tyr Ser Met Met Ser Trp Pro Asp Asp Val Pro Pro Glu Gly Trp 
            340                 345                 350         


Asn Arg Thr Arg His Val Ile Ile Leu Met Thr Asp Gly Leu His Asn 
        355                 360                 365             


Met Gly Gly Asp Pro Ile Thr Val Ile Asp Glu Ile Arg Asp Leu Leu 
    370                 375                 380                 


Tyr Ile Gly Lys Asp Arg Lys Asn Pro Arg Glu Asp Tyr Leu Asp Val 
385                 390                 395                 400 


Tyr Val Phe Gly Val Gly Pro Leu Val Asn Gln Val Asn Ile Asn Ala 
                405                 410                 415     


Leu Ala Ser Lys Lys Asp Asn Glu Gln His Val Phe Lys Val Lys Asp 
            420                 425                 430         


Met Glu Asn Leu Glu Asp Val Phe Tyr Gln Met Ile Asp Glu Ser Gln 
        435                 440                 445             


Ser Leu Ser Leu Cys Gly Met Val Trp Glu His Arg Lys Gly Thr Asp 
    450                 455                 460                 


Tyr His Lys Gln Pro Trp Gln Ala Lys Ile Ser Val Ile Arg Pro Ser 
465                 470                 475                 480 


Lys Gly His Glu Ser Cys Met Gly Ala Val Val Ser Glu Tyr Phe Val 
                485                 490                 495     


Leu Thr Ala Ala His Cys Phe Thr Val Asp Asp Lys Glu His Ser Ile 
            500                 505                 510         


Lys Val Ser Val Gly Gly Glu Lys Arg Asp Leu Glu Ile Glu Val Val 
        515                 520                 525             


Leu Phe His Pro Asn Tyr Asn Ile Asn Gly Lys Lys Glu Ala Gly Ile 
    530                 535                 540                 


Pro Glu Phe Tyr Asp Tyr Asp Val Ala Leu Ile Lys Leu Lys Asn Lys 
545                 550                 555                 560 


Leu Lys Tyr Gly Gln Thr Ile Arg Pro Ile Cys Leu Pro Cys Thr Glu 
                565                 570                 575     


Gly Thr Thr Arg Ala Leu Arg Leu Pro Pro Thr Thr Thr Cys Gln Gln 
            580                 585                 590         


Gln Lys Glu Glu Leu Leu Pro Ala Gln Asp Ile Lys Ala Leu Phe Val 
        595                 600                 605             


Ser Glu Glu Glu Lys Lys Leu Thr Arg Lys Glu Val Tyr Ile Lys Asn 
    610                 615                 620                 


Gly Asp Lys Lys Gly Ser Cys Glu Arg Asp Ala Gln Tyr Ala Pro Gly 
625                 630                 635                 640 


Tyr Asp Lys Val Lys Asp Ile Ser Glu Val Val Thr Pro Arg Phe Leu 
                645                 650                 655     


Cys Thr Gly Gly Val Ser Pro Tyr Ala Asp Pro Asn Thr Cys Arg Gly 
            660                 665                 670         


Asp Ser Gly Gly Pro Leu Ile Val His Lys Arg Ser Arg Phe Ile Gln 
        675                 680                 685             


Val Gly Val Ile Ser Trp Gly Val Val Asp Val Cys Lys Asn Gln Lys 
    690                 695                 700                 


Arg Gln Lys Gln Val Pro Ala His Ala Arg Asp Phe His Ile Asn Leu 
705                 710                 715                 720 


Phe Gln Val Leu Pro Trp Leu Lys Glu Lys Leu Gln Asp Glu Asp Leu 
                725                 730                 735     


Gly Phe Leu 
            


<210>  2
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  2

Thr Pro Trp Ser Leu Ala Trp Pro Gln Gly Ser Cys Ser Leu Glu Gly 
1               5                   10                  15      


Val Glu Ile Lys Gly Gly Ser Phe Arg Leu Leu Gln Glu Gly Gln Ala 
            20                  25                  30          


Leu Glu Tyr Val Cys Pro Ser Gly Phe Tyr Pro Tyr Pro Val Gln Thr 
        35                  40                  45              


Arg Thr Cys Arg Ser Thr Gly Ser Trp Ser Thr Leu Lys Thr Gln Asp 
    50                  55                  60                  


Gln Lys Thr Val Arg Lys Ala Glu Cys Arg Ala Ile His Cys Pro Arg 
65                  70                  75                  80  


Pro His Asp Phe Glu Asn Gly Glu Tyr Trp Pro Arg Ser Pro Tyr Tyr 
                85                  90                  95      


Asn Val Ser Asp Glu Ile Ser Phe His Cys Tyr Asp Gly Tyr Thr Leu 
            100                 105                 110         


Arg Gly Ser Ala Asn Arg Thr Cys Gln Val Asn Gly Arg Trp Ser Gly 
        115                 120                 125             


Gln Thr Ala Ile Cys Asp Asn Gly Ala Gly Tyr Cys Ser Asn Pro Gly 
    130                 135                 140                 


Ile Pro Ile Gly Thr Arg Lys Val Gly Ser Gln Tyr Arg Leu Glu Asp 
145                 150                 155                 160 


Ser Val Thr Tyr His Cys Ser Arg Gly Leu Thr Leu Arg Gly Ser Gln 
                165                 170                 175     


Arg Arg Thr Cys Gln Glu Gly Gly Ser Trp Ser Gly Thr Glu Pro Ser 
            180                 185                 190         


Cys Gln Asp Ser Phe Met Tyr Asp Thr Pro Gln Glu Val Ala Glu Ala 
        195                 200                 205             


Phe Leu Ser Ser Leu Thr Glu Thr Ile Glu Gly Val Asp Ala Glu Asp 
    210                 215                 220                 


Gly His Gly Pro Gly Glu Gln Gln Lys Arg 
225                 230                 


<210>  3
<211>  504
<212>  PRT
<213>  Homo sapiens

<400>  3

Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu Val Leu 
1               5                   10                  15      


Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly Ala Lys Lys 
            20                  25                  30          


Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly Val Lys Pro 
        35                  40                  45              


Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr Pro Lys Ile Trp Val Lys 
    50                  55                  60                  


Val Ser Glu Ala Asp Ser Ser Asn Ala Asp Trp Val Thr Lys Gln Leu 
65                  70                  75                  80  


Asn Glu Ile Asn Tyr Glu Asp His Lys Leu Lys Ser Gly Thr Asn Thr 
                85                  90                  95      


Lys Lys Ala Leu Gln Ala Val Tyr Ser Met Met Ser Trp Pro Asp Asp 
            100                 105                 110         


Val Pro Pro Glu Gly Trp Asn Arg Thr Arg His Val Ile Ile Leu Met 
        115                 120                 125             


Thr Asp Gly Leu His Asn Met Gly Gly Asp Pro Ile Thr Val Ile Asp 
    130                 135                 140                 


Glu Ile Arg Asp Leu Tyr Ile Gly Lys Asp Arg Lys Asn Pro Arg Glu 
145                 150                 155                 160 


Asp Tyr Leu Asp Val Tyr Val Phe Gly Val Gly Pro Leu Val Asn Gln 
                165                 170                 175     


Val Asn Ile Asn Ala Leu Ala Ser Lys Lys Asp Asn Glu Gln His Val 
            180                 185                 190         


Phe Lys Val Lys Asp Met Glu Asn Leu Glu Asp Val Phe Tyr Gln Met 
        195                 200                 205             


Ile Asp Glu Ser Gln Ser Leu Ser Leu Cys Gly Met Val Trp Glu His 
    210                 215                 220                 


Arg Lys Gly Thr Asp Tyr His Lys Gln Pro Trp Gln Ala Lys Ile Ser 
225                 230                 235                 240 


Val Ile Arg Pro Ser Lys Gly His Glu Ser Cys Met Gly Ala Val Val 
                245                 250                 255     


Ser Glu Tyr Phe Val Leu Thr Ala Ala His Cys Phe Thr Val Asp Asp 
            260                 265                 270         


Lys Glu His Ser Ile Lys Val Ser Val Gly Gly Glu Lys Arg Asp Leu 
        275                 280                 285             


Glu Ile Glu Val Val Leu Phe His Pro Asn Tyr Asn Ile Asn Gly Lys 
    290                 295                 300                 


Lys Glu Ala Gly Ile Pro Glu Phe Tyr Asp Tyr Asp Val Ala Leu Ile 
305                 310                 315                 320 


Lys Leu Lys Asn Lys Leu Lys Tyr Gly Gln Thr Ile Arg Pro Ile Cys 
                325                 330                 335     


Leu Pro Cys Thr Glu Gly Thr Thr Arg Ala Leu Arg Leu Pro Pro Thr 
            340                 345                 350         


Thr Thr Cys Gln Gln Gln Lys Glu Glu Leu Leu Pro Ala Gln Asp Ile 
        355                 360                 365             


Lys Ala Leu Phe Val Ser Glu Glu Glu Lys Lys Leu Thr Arg Lys Glu 
    370                 375                 380                 


Val Tyr Ile Lys Asn Gly Asp Lys Lys Gly Ser Cys Glu Arg Asp Ala 
385                 390                 395                 400 


Gln Tyr Ala Pro Gly Tyr Asp Lys Val Lys Asp Ile Ser Glu Val Val 
                405                 410                 415     


Thr Pro Arg Phe Leu Cys Thr Gly Gly Val Ser Pro Tyr Ala Asp Pro 
            420                 425                 430         


Asn Thr Cys Arg Gly Asp Ser Gly Gly Pro Leu Ile Val His Lys Arg 
        435                 440                 445             


Ser Arg Phe Ile Gln Val Gly Val Ile Ser Trp Gly Val Val Asp Val 
    450                 455                 460                 


Cys Lys Asn Gln Lys Arg Gln Lys Gln Val Pro Ala His Ala Arg Asp 
465                 470                 475                 480 


Phe His Ile Asn Leu Phe Gln Val Leu Pro Trp Leu Lys Glu Lys Leu 
                485                 490                 495     


Gln Asp Glu Asp Leu Gly Phe Leu 
            500                 


<210>  4
<211>  45
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Ile Val Leu Asp Pro Ser Gly Ser Met Asn Ile Tyr Leu Val Leu 
1               5                   10                  15      


Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn Phe Thr Gly Ala Lys Lys 
            20                  25                  30          


Cys Leu Val Asn Leu Ile Glu Lys Val Ala Ser Tyr Gly 
        35                  40                  45  


<210>  5
<211>  200
<212>  PRT
<213>  Homo sapiens

<400>  5

Asn Ile Tyr Leu Val Leu Asp Gly Ser Asp Ser Ile Gly Ala Ser Asn 
1               5                   10                  15      


Phe Thr Gly Ala Lys Lys Cys Leu Val Asn Leu Ile Glu Lys Val Ala 
            20                  25                  30          


Ser Tyr Gly Val Lys Pro Arg Tyr Gly Leu Val Thr Tyr Ala Thr Tyr 
        35                  40                  45              


Pro Lys Ile Trp Val Lys Val Ser Glu Ala Asp Ser Ser Asn Ala Asp 
    50                  55                  60                  


Trp Val Thr Lys Gln Leu Asn Glu Ile Asn Tyr Glu Asp His Lys Leu 
65                  70                  75                  80  


Lys Ser Gly Thr Asn Thr Lys Lys Ala Leu Gln Ala Val Tyr Ser Met 
                85                  90                  95      


Met Ser Trp Pro Asp Asp Val Pro Pro Glu Gly Trp Asn Arg Thr Arg 
            100                 105                 110         


His Val Ile Ile Leu Met Thr Asp Gly Leu His Asn Met Gly Gly Asp 
        115                 120                 125             


Pro Ile Thr Val Ile Asp Glu Ile Arg Asp Leu Leu Tyr Ile Gly Lys 
    130                 135                 140                 


Asp Arg Lys Asn Pro Arg Glu Asp Tyr Leu Asp Val Tyr Val Phe Gly 
145                 150                 155                 160 


Val Gly Pro Leu Val Asn Gln Val Asn Ile Asn Ala Leu Ala Ser Lys 
                165                 170                 175     


Lys Asp Asn Glu Gln His Val Phe Lys Val Lys Asp Met Glu Asn Leu 
            180                 185                 190         


Glu Asp Val Phe Tyr Gln Met Ile 
        195                 200 


<210>  6
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  6

Leu Cys Gly Met Val Trp Glu His Arg Lys Gly Thr Asp Tyr His Lys 
1               5                   10                  15      


Gln Pro Trp Gln Ala Lys Ile Ser Val Ile Arg Pro Ser Lys Gly His 
            20                  25                  30          


Glu Ser Cys Met Gly Ala Val Val Ser Glu Tyr Phe Val Leu Thr Ala 
        35                  40                  45              


Ala His Cys Phe Thr Val Asp Asp Lys Glu His Ser Ile Lys Val Ser 
    50                  55                  60                  


Val Gly Gly Glu Lys Arg Asp Leu Glu Ile Glu Val Val Leu Phe His 
65                  70                  75                  80  


Pro Asn Tyr Asn Ile Asn Gly Lys Lys Glu Ala Gly Ile Pro Glu Phe 
                85                  90                  95      


Tyr Asp Tyr Asp Val Ala Leu Ile Lys Leu Lys Asn Lys Leu Lys Tyr 
            100                 105                 110         


Gly Gln Thr Ile Arg Pro Ile Cys Leu Pro Cys Thr Glu Gly Thr Thr 
        115                 120                 125             


Arg Ala Leu Arg Leu Pro Pro Thr Thr Thr Cys Gln Gln Gln Lys Glu 
    130                 135                 140                 


Glu Leu Leu Pro Ala Gln Asp Ile Lys Ala Leu Phe Val Ser Glu Glu 
145                 150                 155                 160 


Glu Lys Lys Leu Thr Arg Lys Glu Val Tyr Ile Lys Asn Gly Asp Lys 
                165                 170                 175     


Lys Gly Ser Cys Glu Arg Asp Ala Gln Tyr Ala Pro Gly Tyr Asp Lys 
            180                 185                 190         


Val Lys Asp Ile Ser Glu Val Val Thr Pro Arg Phe Leu Cys Thr Gly 
        195                 200                 205             


Gly Val Ser Pro Tyr Ala Asp Pro Asn Thr Cys Arg Gly Asp Ser Gly 
    210                 215                 220                 


Gly Pro Leu Ile Val His Lys Arg Ser Arg Phe Ile Gln Val Gly Val 
225                 230                 235                 240 


Ile Ser Trp Gly Val Val Asp Val Cys Lys Asn Gln Lys Arg Gln Lys 
                245                 250                 255     


Gln Val Pro Ala His Ala Arg Asp Phe His Ile Asn Leu Phe Gln Val 
            260                 265                 270         


Leu Pro Trp Leu Lys Glu Lys Leu Gln Asp 
        275                 280         


