SEQUENCE LISTING

<110>   NOVARTIS VACCINES AND DIAGNOSTICS, INC.
        BARNETT, Susan
	LIAN, Ying
        SRIVASTAVA Indresh
        SHARMA Victoria

<120>   HIV ENV PROTEINS WITH MODIFICATIONS IN THE V3 LOOP
        
<130>   PP028267.0002 

<150>   US 60/966,048
<151>   2007-08-24

<160>   51

<170>   SeqWin99, version 1.02

<210>   1
<211>   856
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   1
Met Arg Val Lys Glu Lys Tyr Gln His Leu Trp Arg Trp Gly Trp Arg 
1               5                   10                  15      

Trp Gly Thr Met Leu Leu Gly Met Leu Met Ile Cys Ser Ala Thr Glu 
            20                  25                  30          

Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala 
        35                  40                  45              

Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu 
    50                  55                  60                  

Val His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn 
65                  70                  75                  80  

Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn Phe Asn Met Trp 
                85                  90                  95      

Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp 
            100                 105                 110         

Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ser 
        115                 120                 125             

Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr Asn Ser Ser Ser 
    130                 135                 140                 

Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn Cys Ser Phe Asn 
145                 150                 155                 160 

Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu Tyr Ala Phe Phe 
                165                 170                 175     

Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr Thr Ser Tyr Lys 
            180                 185                 190         

Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val 
        195                 200                 205             

Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala 
    210                 215                 220                 

Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr 
225                 230                 235                 240 

Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser 
                245                 250                 255     

Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile 
            260                 265                 270         

Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu 
        275                 280                 285             

Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg 
    290                 295                 300                 

Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala Phe Val Thr Ile 
305                 310                 315                 320 

Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn Ile Ser Arg Ala 
                325                 330                 335     

Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln 
            340                 345                 350         

Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp 
        355                 360                 365             

Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr 
    370                 375                 380                 

Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp 
385                 390                 395                 400 

Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu 
                405                 410                 415     

Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys 
            420                 425                 430         

Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn 
        435                 440                 445             

Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu 
    450                 455                 460                 

Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg 
465                 470                 475                 480 

Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val 
                485                 490                 495     

Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala 
            500                 505                 510         

Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser 
        515                 520                 525             

Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln Leu 
    530                 535                 540                 

Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu 
545                 550                 555                 560 

Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu 
                565                 570                 575     

Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu 
            580                 585                 590         

Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val 
        595                 600                 605             

Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp Asn 
    610                 615                 620                 

His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr Ser 
625                 630                 635                 640 

Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn 
                645                 650                 655     

Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp 
            660                 665                 670         

Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met Ile 
        675                 680                 685             

Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser Ile 
    690                 695                 700                 

Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr His 
705                 710                 715                 720 

Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu 
                725                 730                 735     

Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly Ser 
            740                 745                 750         

Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr 
        755                 760                 765             

His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu Leu 
    770                 775                 780                 

Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu Leu 
785                 790                 795                 800 

Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu Asn 
                805                 810                 815     

Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu Val 
            820                 825                 830         

Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile Arg 
        835                 840                 845             

Gln Gly Leu Glu Arg Ile Leu Leu 
    850                 855     

<210>   2
<211>   966
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   2
Ser Ala Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Ser Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr 
            100                 105                 110         

Asn Ser Ser Ser Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn 
        115                 120                 125             

Cys Ser Phe Asn Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu 
    130                 135                 140                 

Tyr Ala Phe Phe Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr 
145                 150                 155                 160 

Thr Ser Tyr Lys Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala 
                165                 170                 175     

Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
            180                 185                 190         

Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr 
        195                 200                 205             

Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg 
    210                 215                 220                 

Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
225                 230                 235                 240 

Glu Val Val Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile 
                245                 250                 255     

Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn 
            260                 265                 270         

Asn Asn Thr Arg Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala 
        275                 280                 285             

Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn 
    290                 295                 300                 

Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys 
305                 310                 315                 320 

Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser 
                325                 330                 335     

Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly 
            340                 345                 350         

Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe 
        355                 360                 365             

Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp 
    370                 375                 380                 

Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 

Lys Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg 
                405                 410                 415     

Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn 
            420                 425                 430         

Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg 
        435                 440                 445             

Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
    450                 455                 460                 

Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg 
465                 470                 475                 480 

Glu Lys Arg Ser Ala Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly 
                485                 490                 495     

Val Pro Val Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp 
            500                 505                 510         

Ala Lys Ala Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala 
        515                 520                 525             

Cys Val Pro Thr Asp Pro Asn Pro Gln Glu Val Val Leu Val Asn Val 
    530                 535                 540                 

Thr Glu Asn Phe Asn Met Trp Lys Asn Asp Met Val Glu Gln Met His 
545                 550                 555                 560 

Glu Asp Ile Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys 
                565                 570                 575     

Leu Thr Pro Leu Cys Val Ser Leu Lys Cys Thr Asp Leu Lys Asn Asp 
            580                 585                 590         

Thr Asn Thr Asn Ser Ser Ser Gly Arg Met Ile Met Glu Lys Gly Glu 
        595                 600                 605             

Ile Lys Asn Cys Ser Phe Asn Ile Ser Thr Ser Ile Arg Gly Lys Val 
    610                 615                 620                 

Gln Lys Glu Tyr Ala Phe Phe Tyr Lys Leu Asp Ile Ile Pro Ile Asp 
625                 630                 635                 640 

Asn Asp Thr Thr Ser Tyr Lys Leu Thr Ser Cys Asn Thr Ser Val Ile 
                645                 650                 655     

Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr 
            660                 665                 670         

Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe 
        675                 680                 685             

Asn Gly Thr Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His 
    690                 695                 700                 

Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu 
705                 710                 715                 720 

Ala Glu Glu Glu Val Val Ile Arg Ser Val Asn Phe Thr Asp Asn Ala 
                725                 730                 735     

Lys Thr Ile Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr 
            740                 745                 750         

Arg Pro Asn Asn Asn Thr Arg Lys Arg Ile Arg Ile Gln Arg Gly Pro 
        755                 760                 765             

Gly Arg Ala Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala 
    770                 775                 780                 

His Cys Asn Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile 
785                 790                 795                 800 

Ala Ser Lys Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe 
                805                 810                 815     

Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn 
            820                 825                 830         

Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser 
        835                 840                 845             

Thr Trp Phe Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu 
    850                 855                 860                 

Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn 
865                 870                 875                 880 

Met Trp Gln Lys Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Ser Gly 
                885                 890                 895     

Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp 
            900                 905                 910         

Gly Gly Asn Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly 
        915                 920                 925             

Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
    930                 935                 940                 

Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val 
945                 950                 955                 960 

Val Gln Arg Glu Lys Arg 
                965     

<210>   3
<211>   345
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   3
Ala Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly Ala Ala Gly 
1               5                   10                  15      

Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln Ala Arg Gln 
            20                  25                  30          

Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
        35                  40                  45              

Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
    50                  55                  60                  

Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 
65                  70                  75                  80  

Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
                85                  90                  95      

Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu Gln Ile Trp 
            100                 105                 110         

Asn His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn Asn Tyr Thr 
        115                 120                 125             

Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 
    130                 135                 140                 

Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
145                 150                 155                 160 

Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile Lys Leu Phe Ile Met 
                165                 170                 175     

Ile Val Gly Gly Leu Val Gly Leu Arg Ile Val Phe Ala Val Leu Ser 
            180                 185                 190         

Ile Val Asn Arg Val Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr 
        195                 200                 205             

His Leu Pro Thr Pro Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu 
    210                 215                 220                 

Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser Ile Arg Leu Val Asn Gly 
225                 230                 235                 240 

Ser Leu Ala Leu Ile Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser 
                245                 250                 255     

Tyr His Arg Leu Arg Asp Leu Leu Leu Ile Val Thr Arg Ile Val Glu 
            260                 265                 270         

Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu Lys Tyr Trp Trp Asn Leu 
        275                 280                 285             

Leu Gln Tyr Trp Ser Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Leu 
    290                 295                 300                 

Asn Ala Thr Ala Ile Ala Val Ala Glu Gly Thr Asp Arg Val Ile Glu 
305                 310                 315                 320 

Val Val Gln Gly Ala Cys Arg Ala Ile Arg His Ile Pro Arg Arg Ile 
                325                 330                 335     

Arg Gln Gly Leu Glu Arg Ile Leu Leu 
            340                 345 

<210>   4
<211>   852
<212>   PRT
<213>   Human immunodeficiency virus HIV-2

<220>
<221>   Xaa
<222>   739
<223>   Xaa is any amino acid

<400>   4
Met Cys Gly Lys Ser Leu Leu Cys Val Ala Ser Leu Leu Ala Ser Ala 
1               5                   10                  15      

Tyr Leu Val Tyr Cys Thr Gln Tyr Val Thr Val Phe Tyr Gly Val Pro 
            20                  25                  30          

Val Trp Arg Asn Ala Ser Ile Pro Leu Phe Cys Ala Thr Lys Asn Arg 
        35                  40                  45              

Asp Thr Trp Gly Thr Ile Gln Cys Lys Pro Asp Asn Asp Asp Tyr Gln 
    50                  55                  60                  

Glu Ile Thr Leu Asn Val Thr Glu Ala Phe Asp Ala Trp Asp Asn Thr 
65                  70                  75                  80  

Val Thr Glu Gln Ala Val Glu Asp Val Trp Ser Leu Phe Glu Thr Ser 
                85                  90                  95      

Ile Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Ala Met Ser Cys 
            100                 105                 110         

Asn Ser Thr Thr Asn Asn Thr Thr Thr Thr Gly Ser Thr Thr Gly Met 
        115                 120                 125             

Ser Glu Ile Asn Glu Thr Ser Pro Ser Tyr Ser Asp Asn Cys Thr Gly 
    130                 135                 140                 

Leu Gly Lys Glu Glu Ile Val Asn Cys Gln Phe Tyr Met Thr Gly Leu 
145                 150                 155                 160 

Glu Arg Asp Lys Lys Lys Gln Tyr Asn Glu Thr Trp Tyr Ser Lys Asp 
                165                 170                 175     

Val Val Cys Glu Ser Asn Asn Thr Lys Asp Gly Lys Asn Arg Cys Tyr 
            180                 185                 190         

Met Asn His Cys Asn Thr Ser Val Ile Thr Glu Ser Cys Asp Lys His 
        195                 200                 205             

Tyr Trp Asp Ala Ile Lys Phe Arg Tyr Cys Ala Pro Pro Gly Tyr Ala 
    210                 215                 220                 

Leu Leu Arg Cys Asn Asp Thr Asn Tyr Ser Gly Phe Glu Pro Lys Cys 
225                 230                 235                 240 

Ser Lys Val Val Ala Ser Thr Cys Thr Arg Met Met Glu Thr Gln Thr 
                245                 250                 255     

Ser Thr Trp Phe Gly Phe Asn Gly Thr Arg Ala Glu Asn Arg Thr Tyr 
            260                 265                 270         

Ile Tyr Trp His Gly Arg Asp Asn Arg Thr Ile Ile Ser Leu Asn Lys 
        275                 280                 285             

Tyr Tyr Asn Leu Ser Ile His Cys Lys Arg Pro Gly Asn Lys Thr Val 
    290                 295                 300                 

Val Pro Ile Thr Leu Met Ser Gly Leu Val Phe His Ser Gln Pro Ile 
305                 310                 315                 320 

Asn Thr Arg Pro Arg Gln Ala Trp Cys Trp Phe Lys Gly Lys Trp Arg 
                325                 330                 335     

Glu Ala Met Gln Glu Val Lys Gln Thr Leu Ile Lys His Pro Arg Tyr 
            340                 345                 350         

Lys Gly Thr Asn Asp Thr Lys Asn Ile Asn Phe Thr Lys Pro Gly Arg 
        355                 360                 365             

Gly Ser Asp Pro Glu Val Ala Tyr Met Trp Thr Asn Cys Arg Gly Glu 
    370                 375                 380                 

Phe Leu Tyr Cys Asn Met Thr Trp Phe Leu Asn Trp Val Glu Asn Arg 
385                 390                 395                 400 

Pro Asn Gln Thr Gln His Asn Tyr Ala Pro Cys His Ile Arg Gln Ile 
                405                 410                 415     

Ile Asn Thr Trp His Lys Val Gly Lys Asn Val Tyr Leu Pro Pro Arg 
            420                 425                 430         

Glu Gly Gln Leu Thr Cys Asn Ser Thr Val Thr Ser Ile Ile Ala Asn 
        435                 440                 445             

Ile Asp Val Asn Ser Asn Gln Thr Asn Ile Thr Phe Ser Ala Glu Val 
    450                 455                 460                 

Ala Glu Leu Tyr Arg Leu Glu Leu Gly Asp Tyr Lys Leu Ile Glu Val 
465                 470                 475                 480 

Thr Pro Ile Gly Phe Ala Pro Thr Arg Glu Lys Arg Tyr Ser Ser Ala 
                485                 490                 495     

Pro Val Arg Asn Lys Arg Gly Val Phe Val Leu Gly Phe Leu Gly Phe 
            500                 505                 510         

Leu Ala Thr Ala Gly Ser Ala Met Gly Ala Ala Ser Leu Thr Leu Ser 
        515                 520                 525             

Ala Gln Ser Arg Thr Leu Leu Ala Gly Ile Val Gln Gln Gln Gln Gln 
    530                 535                 540                 

Leu Leu Asp Val Val Lys Arg Gln Gln Glu Met Leu Arg Leu Thr Val 
545                 550                 555                 560 

Trp Gly Thr Lys Asn Leu Gln Ala Arg Val Thr Ala Ile Glu Lys Tyr 
                565                 570                 575     

Leu Lys Asp Gln Ala Gln Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln 
            580                 585                 590         

Val Cys His Thr Thr Val Pro Trp Val Asn Asp Ser Leu Ser Pro Asp 
        595                 600                 605             

Trp Asn Asn Met Thr Trp Gln Glu Trp Glu Lys Gln Val Arg Tyr Leu 
    610                 615                 620                 

Glu Ala Asn Ile Ser Gln Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu 
625                 630                 635                 640 

Lys Asn Met Tyr Glu Leu Gln Lys Leu Asn Ser Trp Asp Val Phe Gly 
                645                 650                 655     

Asn Trp Phe Asp Leu Thr Ser Trp Ile Lys Tyr Ile Gln Tyr Gly Val 
            660                 665                 670         

Tyr Ile Val Val Gly Val Ile Val Leu Arg Ile Ala Ile Tyr Ile Val 
        675                 680                 685             

Gln Leu Leu Ser Arg Leu Arg Lys Gly Tyr Arg Pro Val Phe Ser Ser 
    690                 695                 700                 

Pro Pro Gly Tyr Leu Gln Gln Ile His Ile His Thr Asp Arg Gly Gln 
705                 710                 715                 720 

Pro Ala Asn Glu Gly Thr Glu Glu Asp Asp Arg Asp Asp Asp Gly Tyr 
                725                 730                 735     

Asp Leu Xaa Pro Trp Pro Ile Asn Tyr Ile His Phe Leu Ile His Leu 
            740                 745                 750         

Leu Thr Arg Leu Leu Thr Gly Leu Tyr Lys Ile Cys Arg Asp Leu Leu 
        755                 760                 765             

Ser Thr Asn Ser Pro Thr His Arg Leu Ile Ser Gln Asn Leu Thr Ala 
    770                 775                 780                 

Ile Arg Asp Trp Leu Arg Leu Lys Ala Ala Tyr Leu Gln Tyr Gly Gly 
785                 790                 795                 800 

Glu Trp Ile Gln Glu Ala Phe Gln Ala Phe Ala Lys Thr Thr Arg Glu 
                805                 810                 815     

Thr Leu Ala Ser Ala Trp Gly Gly Leu Cys Ala Ala Val Gln Arg Val 
            820                 825                 830         

Gly Arg Gly Ile Leu Ala Val Pro Arg Arg Ile Arg Gln Gly Ala Glu 
        835                 840                 845             

Ile Ala Leu Leu 
    850         

<210>   5
<211>   483
<212>   PRT
<213>   Human immunodeficiency virus HIV-2

<400>   5
Tyr Cys Thr Gln Tyr Val Thr Val Phe Tyr Gly Val Pro Val Trp Arg 
1               5                   10                  15      

Asn Ala Ser Ile Pro Leu Phe Cys Ala Thr Lys Asn Arg Asp Thr Trp 
            20                  25                  30          

Gly Thr Ile Gln Cys Lys Pro Asp Asn Asp Asp Tyr Gln Glu Ile Thr 
        35                  40                  45              

Leu Asn Val Thr Glu Ala Phe Asp Ala Trp Asp Asn Thr Val Thr Glu 
    50                  55                  60                  

Gln Ala Val Glu Asp Val Trp Ser Leu Phe Glu Thr Ser Ile Lys Pro 
65                  70                  75                  80  

Cys Val Lys Leu Thr Pro Leu Cys Val Ala Met Ser Cys Asn Ser Thr 
                85                  90                  95      

Thr Asn Asn Thr Thr Thr Thr Gly Ser Thr Thr Gly Met Ser Glu Ile 
            100                 105                 110         

Asn Glu Thr Ser Pro Ser Tyr Ser Asp Asn Cys Thr Gly Leu Gly Lys 
        115                 120                 125             

Glu Glu Ile Val Asn Cys Gln Phe Tyr Met Thr Gly Leu Glu Arg Asp 
    130                 135                 140                 

Lys Lys Lys Gln Tyr Asn Glu Thr Trp Tyr Ser Lys Asp Val Val Cys 
145                 150                 155                 160 

Glu Ser Asn Asn Thr Lys Asp Gly Lys Asn Arg Cys Tyr Met Asn His 
                165                 170                 175     

Cys Asn Thr Ser Val Ile Thr Glu Ser Cys Asp Lys His Tyr Trp Asp 
            180                 185                 190         

Ala Ile Lys Phe Arg Tyr Cys Ala Pro Pro Gly Tyr Ala Leu Leu Arg 
        195                 200                 205             

Cys Asn Asp Thr Asn Tyr Ser Gly Phe Glu Pro Lys Cys Ser Lys Val 
    210                 215                 220                 

Val Ala Ser Thr Cys Thr Arg Met Met Glu Thr Gln Thr Ser Thr Trp 
225                 230                 235                 240 

Phe Gly Phe Asn Gly Thr Arg Ala Glu Asn Arg Thr Tyr Ile Tyr Trp 
                245                 250                 255     

His Gly Arg Asp Asn Arg Thr Ile Ile Ser Leu Asn Lys Tyr Tyr Asn 
            260                 265                 270         

Leu Ser Ile His Cys Lys Arg Pro Gly Asn Lys Thr Val Val Pro Ile 
        275                 280                 285             

Thr Leu Met Ser Gly Leu Val Phe His Ser Gln Pro Ile Asn Thr Arg 
    290                 295                 300                 

Pro Arg Gln Ala Trp Cys Trp Phe Lys Gly Lys Trp Arg Glu Ala Met 
305                 310                 315                 320 

Gln Glu Val Lys Gln Thr Leu Ile Lys His Pro Arg Tyr Lys Gly Thr 
                325                 330                 335     

Asn Asp Thr Lys Asn Ile Asn Phe Thr Lys Pro Gly Arg Gly Ser Asp 
            340                 345                 350         

Pro Glu Val Ala Tyr Met Trp Thr Asn Cys Arg Gly Glu Phe Leu Tyr 
        355                 360                 365             

Cys Asn Met Thr Trp Phe Leu Asn Trp Val Glu Asn Arg Pro Asn Gln 
    370                 375                 380                 

Thr Gln His Asn Tyr Ala Pro Cys His Ile Arg Gln Ile Ile Asn Thr 
385                 390                 395                 400 

Trp His Lys Val Gly Lys Asn Val Tyr Leu Pro Pro Arg Glu Gly Gln 
                405                 410                 415     

Leu Thr Cys Asn Ser Thr Val Thr Ser Ile Ile Ala Asn Ile Asp Val 
            420                 425                 430         

Asn Ser Asn Gln Thr Asn Ile Thr Phe Ser Ala Glu Val Ala Glu Leu 
        435                 440                 445             

Tyr Arg Leu Glu Leu Gly Asp Tyr Lys Leu Ile Glu Val Thr Pro Ile 
    450                 455                 460                 

Gly Phe Ala Pro Thr Arg Glu Lys Arg Tyr Ser Ser Ala Pro Val Arg 
465                 470                 475                 480 

Asn Lys Arg 
            

<210>   6
<211>   350
<212>   PRT
<213>   Human immunodeficiency virus HIV-2

<220>
<221>   Xaa
<222>   237
<223>   Xaa is any amino acid

<400>   6
Gly Val Phe Val Leu Gly Phe Leu Gly Phe Leu Ala Thr Ala Gly Ser 
1               5                   10                  15      

Ala Met Gly Ala Ala Ser Leu Thr Leu Ser Ala Gln Ser Arg Thr Leu 
            20                  25                  30          

Leu Ala Gly Ile Val Gln Gln Gln Gln Gln Leu Leu Asp Val Val Lys 
        35                  40                  45              

Arg Gln Gln Glu Met Leu Arg Leu Thr Val Trp Gly Thr Lys Asn Leu 
    50                  55                  60                  

Gln Ala Arg Val Thr Ala Ile Glu Lys Tyr Leu Lys Asp Gln Ala Gln 
65                  70                  75                  80  

Leu Asn Ser Trp Gly Cys Ala Phe Arg Gln Val Cys His Thr Thr Val 
                85                  90                  95      

Pro Trp Val Asn Asp Ser Leu Ser Pro Asp Trp Asn Asn Met Thr Trp 
            100                 105                 110         

Gln Glu Trp Glu Lys Gln Val Arg Tyr Leu Glu Ala Asn Ile Ser Gln 
        115                 120                 125             

Ser Leu Glu Gln Ala Gln Ile Gln Gln Glu Lys Asn Met Tyr Glu Leu 
    130                 135                 140                 

Gln Lys Leu Asn Ser Trp Asp Val Phe Gly Asn Trp Phe Asp Leu Thr 
145                 150                 155                 160 

Ser Trp Ile Lys Tyr Ile Gln Tyr Gly Val Tyr Ile Val Val Gly Val 
                165                 170                 175     

Ile Val Leu Arg Ile Ala Ile Tyr Ile Val Gln Leu Leu Ser Arg Leu 
            180                 185                 190         

Arg Lys Gly Tyr Arg Pro Val Phe Ser Ser Pro Pro Gly Tyr Leu Gln 
        195                 200                 205             

Gln Ile His Ile His Thr Asp Arg Gly Gln Pro Ala Asn Glu Gly Thr 
    210                 215                 220                 

Glu Glu Asp Asp Arg Asp Asp Asp Gly Tyr Asp Leu Xaa Pro Trp Pro 
225                 230                 235                 240 

Ile Asn Tyr Ile His Phe Leu Ile His Leu Leu Thr Arg Leu Leu Thr 
                245                 250                 255     

Gly Leu Tyr Lys Ile Cys Arg Asp Leu Leu Ser Thr Asn Ser Pro Thr 
            260                 265                 270         

His Arg Leu Ile Ser Gln Asn Leu Thr Ala Ile Arg Asp Trp Leu Arg 
        275                 280                 285             

Leu Lys Ala Ala Tyr Leu Gln Tyr Gly Gly Glu Trp Ile Gln Glu Ala 
    290                 295                 300                 

Phe Gln Ala Phe Ala Lys Thr Thr Arg Glu Thr Leu Ala Ser Ala Trp 
305                 310                 315                 320 

Gly Gly Leu Cys Ala Ala Val Gln Arg Val Gly Arg Gly Ile Leu Ala 
                325                 330                 335     

Val Pro Arg Arg Ile Arg Gln Gly Ala Glu Ile Ala Leu Leu 
            340                 345                 350 

<210>   7
<211>   820
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   7
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Ser Phe Lys Val Thr Thr Ser Ile Arg Asn Lys Met Gln Lys Glu Tyr 
    130                 135                 140                 

Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr 
145                 150                 155                 160 

Ser Tyr Lys Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
                165                 170                 175     

Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
            180                 185                 190         

Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly 
        195                 200                 205             

Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
    210                 215                 220                 

Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly 
225                 230                 235                 240 

Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile 
                245                 250                 255     

Val Gln Leu Lys Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
            260                 265                 270         

Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala 
        275                 280                 285             

Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
    290                 295                 300                 

Gly Glu Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln 
305                 310                 315                 320 

Ala Gln Phe Gly Asn Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly 
                325                 330                 335     

Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
            340                 345                 350         

Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile 
        355                 360                 365             

Gly Pro Asn Asn Thr Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
    370                 375                 380                 

Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro 
385                 390                 395                 400 

Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
                405                 410                 415     

Leu Thr Arg Asp Gly Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe 
            420                 425                 430         

Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
        435                 440                 445             

Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
    450                 455                 460                 

Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Thr Leu Gly 
465                 470                 475                 480 

Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
                485                 490                 495     

Arg Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
            500                 505                 510         

Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
        515                 520                 525             

Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
    530                 535                 540                 

Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
545                 550                 555                 560 

Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala 
                565                 570                 575     

Ser Trp Ser Asn Lys Ser Leu Asp Gln Ile Trp Asn Asn Met Thr Trp 
            580                 585                 590         

Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asn Leu Ile Tyr Thr 
        595                 600                 605             

Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
    610                 615                 620                 

Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser 
625                 630                 635                 640 

Lys Trp Leu Trp Tyr Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu 
                645                 650                 655     

Val Gly Leu Arg Ile Val Phe Thr Val Leu Ser Ile Val Asn Arg Val 
            660                 665                 670         

Arg Gln Gly Tyr Ser Pro Leu Ser Phe Gln Thr Arg Phe Pro Ala Pro 
        675                 680                 685             

Arg Gly Pro Asp Arg Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg 
    690                 695                 700                 

Asp Arg Asp Arg Ser Ser Pro Leu Val His Gly Leu Leu Ala Leu Ile 
705                 710                 715                 720 

Trp Asp Asp Leu Arg Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg 
                725                 730                 735     

Asp Leu Ile Leu Ile Ala Ala Arg Ile Val Glu Leu Leu Gly Arg Arg 
            740                 745                 750         

Gly Trp Glu Ala Leu Lys Tyr Trp Gly Asn Leu Leu Gln Tyr Trp Ile 
        755                 760                 765             

Gln Glu Leu Lys Asn Ser Ala Val Ser Leu Phe Asp Ala Ile Ala Ile 
    770                 775                 780                 

Ala Val Ala Glu Gly Thr Asp Arg Ile Ile Glu Val Ala Gln Arg Ile 
785                 790                 795                 800 

Gly Arg Ala Phe Leu His Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu 
                805                 810                 815     

Arg Ala Leu Leu 
            820 

<210>   8
<211>   411
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<220>
<221>   Xaa
<222>   130, 231
<223>   Xaa is a mutant loop

<400>   8
Ser Ala Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Ser Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr 
            100                 105                 110         

Asn Ser Ser Ser Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn 
        115                 120                 125             

Cys Xaa Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser 
    130                 135                 140                 

Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile 
145                 150                 155                 160 

Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr Gly Pro Cys Thr Asn 
                165                 170                 175     

Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr 
            180                 185                 190         

Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Glu Val Val Ile Arg 
        195                 200                 205             

Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Asn 
    210                 215                 220                 

Thr Ser Val Glu Ile Asn Xaa Asn Ile Ser Arg Ala Lys Trp Asn Asn 
225                 230                 235                 240 

Thr Leu Lys Gln Ile Ala Ser Lys Leu Arg Glu Gln Phe Gly Asn Asn 
                245                 250                 255     

Lys Thr Ile Ile Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
            260                 265                 270         

Thr His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
        275                 280                 285             

Gln Leu Phe Asn Ser Thr Trp Phe Asn Ser Thr Trp Ser Thr Glu Gly 
    290                 295                 300                 

Ser Asn Asn Thr Glu Gly Ser Asp Thr Ile Thr Leu Pro Cys Arg Ile 
305                 310                 315                 320 

Lys Gln Ile Ile Asn Met Trp Gln Lys Val Gly Lys Ala Met Tyr Ala 
                325                 330                 335     

Pro Pro Ile Ser Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu 
            340                 345                 350         

Leu Leu Thr Arg Asp Gly Gly Asn Ser Asn Asn Glu Ser Glu Ile Phe 
        355                 360                 365             

Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
    370                 375                 380                 

Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
385                 390                 395                 400 

Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
                405                 410     

<210>   9
<211>   619
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   9
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Ser Phe Lys Val Gly Ala Gly Lys Leu Ile Asn Cys Asn Thr Ser Val 
    130                 135                 140                 

Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
145                 150                 155                 160 

Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys 
                165                 170                 175     

Phe Asn Gly Ser Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr 
            180                 185                 190         

His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
        195                 200                 205             

Leu Ala Glu Glu Gly Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn 
    210                 215                 220                 

Ala Lys Thr Ile Ile Val Gln Leu Lys Glu Ser Val Glu Ile Asn Cys 
225                 230                 235                 240 

Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly 
                245                 250                 255     

Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
            260                 265                 270         

His Cys Asn Ile Ser Gly Glu Lys Trp Asn Asn Thr Leu Lys Gln Ile 
        275                 280                 285             

Val Thr Lys Leu Gln Ala Gln Phe Gly Asn Lys Thr Ile Val Phe Lys 
    290                 295                 300                 

Gln Ser Ser Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys 
305                 310                 315                 320 

Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr 
                325                 330                 335     

Trp Asn Asn Thr Ile Gly Pro Asn Asn Thr Asn Gly Thr Ile Thr Leu 
            340                 345                 350         

Pro Cys Arg Ile Lys Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys 
        355                 360                 365             

Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn 
    370                 375                 380                 

Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Lys Glu Ile Ser Asn 
385                 390                 395                 400 

Thr Thr Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp 
                405                 410                 415     

Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly 
            420                 425                 430         

Val Ala Pro Thr Lys Ala Ile Ser Ser Val Val Gln Ser Glu Lys Ser 
        435                 440                 445             

Ala Val Thr Leu Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly 
    450                 455                 460                 

Ser Thr Met Gly Ala Arg Ser Leu Thr Leu Thr Val Gln Ala Arg Gln 
465                 470                 475                 480 

Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile 
                485                 490                 495     

Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln 
            500                 505                 510         

Leu Gln Ala Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln 
        515                 520                 525             

Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala 
    530                 535                 540                 

Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Gln Ile Trp 
545                 550                 555                 560 

Asn Asn Met Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr 
                565                 570                 575     

Asn Leu Ile Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys 
            580                 585                 590         

Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn 
        595                 600                 605             

Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr Ile 
    610                 615                 

<210>   10
<211>   86
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   10
Met Glu Pro Val Asp Pro Arg Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      

Gln Pro Lys Thr Ala Cys Thr Asn Cys Tyr Cys Lys Lys Cys Cys Phe 
            20                  25                  30          

His Cys Gln Val Cys Phe Ile Thr Lys Ala Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              

Arg Lys Lys Arg Arg Gln Arg Arg Arg Ala His Gln Asn Ser Gln Thr 
    50                  55                  60                  

His Gln Ala Ser Leu Ser Lys Gln Pro Thr Ser Gln Pro Arg Gly Asp 
65                  70                  75                  80  

Pro Thr Gly Pro Lys Glu 
                85      

<210>   11
<211>   130
<212>   PRT
<213>   Human immunodeficiency virus HIV-2

<400>   11
Met Glu Thr Pro Leu Lys Ala Pro Glu Ser Ser Leu Met Ser Tyr Asn 
1               5                   10                  15      

Glu Pro Ser Ser Cys Thr Ser Glu Arg Asp Val Gly Ser Gln Glu Leu 
            20                  25                  30          

Ala Lys Gln Gly Glu Glu Leu Leu Ser Gln Leu His Arg Pro Leu Glu 
        35                  40                  45              

Pro Cys Asn Asn Lys Cys Tyr Cys Lys Gly Cys Cys Phe His Cys Gln 
    50                  55                  60                  

Leu Cys Phe Leu Asn Lys Gly Leu Gly Ile Cys Tyr Asp Arg Lys Gly 
65                  70                  75                  80  

Arg Arg Arg Arg Thr Pro Lys Lys Thr Lys Ala His Ser Ser Ser Ala 
                85                  90                  95      

Ser Asp Lys Ser Ile Ser Thr Arg Thr Gly Asn Ser Gln Pro Glu Lys 
            100                 105                 110         

Lys Gln Lys Lys Thr Leu Glu Thr Thr Leu Glu Thr Ala Arg Gly Leu 
        115                 120                 125             

Gly Arg 
    130 

<210>   12
<211>   86
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   12
Met Glu Pro Val Asp Pro Arg Leu Glu Pro Trp Lys His Pro Gly Ser 
1               5                   10                  15      

Gln Pro Lys Thr Ala Cys Thr Asn Cys Tyr Cys Lys Lys Cys Cys Phe 
            20                  25                  30          

His Cys Gln Val Cys Phe Ile Thr Lys Ala Leu Gly Ile Ser Tyr Gly 
        35                  40                  45              

Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Gly Ser Gln Thr 
    50                  55                  60                  

His Gln Val Ser Leu Ser Lys Gln Pro Thr Ser Gln Ser Arg Gly Asp 
65                  70                  75                  80  

Pro Thr Gly Pro Lys Glu 
                85      

<210>   13
<211>   36
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   13
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Arg Ile Arg Ile Gln Arg 
1               5                   10                  15      

Gly Pro Gly Arg Ala Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg 
            20                  25                  30          

Gln Ala His Cys 
        35      

<210>   14
<211>   34
<212>   PRT
<213>   Human immunodeficiency virus HIV-2

<400>   14
Cys Lys Arg Pro Gly Asn Lys Thr Val Val Pro Ile Thr Leu Met Ser 
1               5                   10                  15      

Gly Leu Val Phe His Ser Gln Pro Ile Asn Thr Arg Pro Arg Gln Ala 
            20                  25                  30          

Trp Cys 
        

<210>   15
<211>   17
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   15
Cys Thr Arg Pro Asn Asn Asn Gly Ala Gly Asp Ile Arg Gln Ala His 
1               5                   10                  15      

Cys 
    

<210>   16
<211>   26
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   16
Cys Thr Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp 
1               5                   10                  15      

Ile Ile Gly Asp Ile Arg Gln Ala His Cys 
            20                  25      

<210>   17
<211>   27
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   17
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro 
1               5                   10                  15      

Gly Arg Ala Phe Tyr Ala Thr Gln Ala His Cys 
            20                  25          

<210>   18
<211>   25
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   18
Cys Thr Arg Pro Asn Asn Asn Thr Arg Phe Tyr Ala Thr Gly Asp Ile 
1               5                   10                  15      

Ile Gly Asp Ile Arg Gln Ala His Cys 
            20                  25  

<210>   19
<211>   21
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   19
Cys Thr Arg Pro Asn Asn Asn Thr Arg Gly Asp Ile Ile Gly Asp Ile 
1               5                   10                  15      

Arg Gln Ala His Cys 
            20      

<210>   20
<211>   18
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   20
Cys Thr Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
1               5                   10                  15      

His Cys 
        

<210>   21
<211>   13
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   21
Cys Thr Arg Pro Asn Asn Asn Thr Arg Gln Ala His Cys 
1               5                   10              

<210>   22
<211>   7
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   22
Cys Thr Gly Ala Gly His Cys 
1               5           

<210>   23
<211>   16
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   23
Cys Thr Arg Pro Asn Asn Asn Thr Arg Gly Ala Gly Gln Ala His Cys 
1               5                   10                  15      


<210>   24
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   24
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro 
1               5                   10                  15      

Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asn Met Arg Gln 
            20                  25                  30          

Ala His Cys 
        35  

<210>   25
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   25
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro 
1               5                   10                  15      

Gly Gln Ala Phe Tyr Ala Thr Asn Asp Val Ile Gly Asn Ile Arg Gln 
            20                  25                  30          

Ala His Cys 
        35  

<210>   26
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   26
Cys Thr Arg Pro Gly Asn Asn Thr Arg Arg Ser Val Arg Ile Gly Pro 
1               5                   10                  15      

Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Ala 
            20                  25                  30          

Ala His Cys 
        35  

<210>   27
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   27
Cys Thr Arg Pro Ser Asn Asn Thr Arg Thr Ser Ile Thr Ile Gly Pro 
1               5                   10                  15      

Gly Gln Val Phe Tyr Arg Thr Gly Asp Ile Ile Gly Asp Ile Arg Lys 
            20                  25                  30          

Ala Tyr Cys 
        35  

<210>   28
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   28
Cys Ile Arg Pro Gly Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro 
1               5                   10                  15      

Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Thr Gly Asp Ile Arg Asn 
            20                  25                  30          

Ala His Cys 
        35  

<210>   29
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   29
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Val Arg Ile Gly Pro 
1               5                   10                  15      

Gly Gln Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
            20                  25                  30          

Ala His Cys 
        35  

<210>   30
<211>   18
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   30
Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr 
1               5                   10                  15      

Gly Asp 
        

<210>   31
<211>   9
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   31
Arg Pro Asn Asn Asn Thr Arg Lys Ser 
1               5                   

<210>   32
<211>   8
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   32
Gly Asp Ile Ile Gly Asp Ile Arg 
1               5               

<210>   33
<211>   10
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   33
Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala 
1               5                   10  

<210>   34
<211>   14
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   34
Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr 
1               5                   10                  

<210>   35
<211>   17
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   35
Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly Arg 
1               5                   10                  15      

Ala 
    

<210>   36
<211>   22
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   36
Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp 
1               5                   10                  15      

Ile Ile Gly Asp Ile Arg 
            20          

<210>   37
<211>   31
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   37
Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly Arg 
1               5                   10                  15      

Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala 
            20                  25                  30      

<210>   38
<211>   847
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   38
Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Gly 
1               5                   10                  15      

Gly Thr Leu Leu Leu Gly Met Leu Met Ile Cys Ser Ala Val Glu Lys 
            20                  25                  30          

Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val Trp Lys Glu Ala Thr 
        35                  40                  45              

Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala Tyr Asp Thr Glu Val 
    50                  55                  60                  

His Asn Val Trp Ala Thr His Ala Cys Val Pro Thr Asp Pro Asn Pro 
65                  70                  75                  80  

Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn Phe Asn Met Trp Lys 
                85                  90                  95      

Asn Asn Met Val Glu Gln Met His Glu Asp Ile Ile Ser Leu Trp Asp 
            100                 105                 110         

Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro Leu Cys Val Thr Leu 
        115                 120                 125             

His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr Lys Ser Ser Asn Trp 
    130                 135                 140                 

Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys Ser Phe Lys Val Thr 
145                 150                 155                 160 

Thr Ser Ile Arg Asn Lys Met Gln Lys Glu Tyr Ala Leu Phe Tyr Lys 
                165                 170                 175     

Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr Ser Tyr Lys Leu Ile 
            180                 185                 190         

Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
        195                 200                 205             

Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
    210                 215                 220                 

Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly Pro Cys Thr Asn Val 
225                 230                 235                 240 

Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
                245                 250                 255     

Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly Val Val Ile Arg Ser 
            260                 265                 270         

Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Lys Glu 
        275                 280                 285             

Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser 
    290                 295                 300                 

Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile 
305                 310                 315                 320 

Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser Gly Glu Lys Trp Asn 
                325                 330                 335     

Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln Ala Gln Phe Gly Asn 
            340                 345                 350         

Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
        355                 360                 365             

Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
    370                 375                 380                 

Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile Gly Pro Asn Asn Thr 
385                 390                 395                 400 

Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Arg 
                405                 410                 415     

Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln 
            420                 425                 430         

Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
        435                 440                 445             

Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe Arg Pro Gly Gly Gly 
    450                 455                 460                 

Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
465                 470                 475                 480 

Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val 
                485                 490                 495     

Val Gln Arg Glu Lys Arg Ala Val Thr Leu Gly Ala Met Phe Leu Gly 
            500                 505                 510         

Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Arg Ser Leu Thr Leu 
        515                 520                 525             

Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn 
    530                 535                 540                 

Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr 
545                 550                 555                 560 

Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val Glu Arg 
                565                 570                 575     

Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys 
            580                 585                 590         

Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys 
        595                 600                 605             

Ser Leu Asp Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp Glu Arg 
    610                 615                 620                 

Glu Ile Asp Asn Tyr Thr Asn Leu Ile Tyr Thr Leu Ile Glu Glu Ser 
625                 630                 635                 640 

Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys 
                645                 650                 655     

Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu Trp Tyr 
            660                 665                 670         

Ile Lys Ile Phe Ile Met Ile Val Gly Gly Leu Val Gly Leu Arg Ile 
        675                 680                 685             

Val Phe Thr Val Leu Ser Ile Val Asn Arg Val Arg Gln Gly Tyr Ser 
    690                 695                 700                 

Pro Leu Ser Phe Gln Thr Arg Phe Pro Ala Pro Arg Gly Pro Asp Arg 
705                 710                 715                 720 

Pro Glu Gly Ile Glu Glu Glu Gly Gly Glu Arg Asp Arg Asp Arg Ser 
                725                 730                 735     

Ser Pro Leu Val His Gly Leu Leu Ala Leu Ile Trp Asp Asp Leu Arg 
            740                 745                 750         

Ser Leu Cys Leu Phe Ser Tyr His Arg Leu Arg Asp Leu Ile Leu Ile 
        755                 760                 765             

Ala Ala Arg Ile Val Glu Leu Leu Gly Arg Arg Gly Trp Glu Ala Leu 
    770                 775                 780                 

Lys Tyr Trp Gly Asn Leu Leu Gln Tyr Trp Ile Gln Glu Leu Lys Asn 
785                 790                 795                 800 

Ser Ala Val Ser Leu Phe Asp Ala Ile Ala Ile Ala Val Ala Glu Gly 
                805                 810                 815     

Thr Asp Arg Ile Ile Glu Val Ala Gln Arg Ile Gly Arg Ala Phe Leu 
            820                 825                 830         

His Ile Pro Arg Arg Ile Arg Gln Gly Phe Glu Arg Ala Leu Leu 
        835                 840                 845         

<210>   39
<211>   646
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   39
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Ser Phe Lys Val Thr Thr Ser Ile Arg Asn Lys Met Gln Lys Glu Tyr 
    130                 135                 140                 

Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr 
145                 150                 155                 160 

Ser Tyr Lys Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
                165                 170                 175     

Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
            180                 185                 190         

Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly 
        195                 200                 205             

Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
    210                 215                 220                 

Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly 
225                 230                 235                 240 

Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile 
                245                 250                 255     

Val Gln Leu Lys Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
            260                 265                 270         

Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala 
        275                 280                 285             

Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
    290                 295                 300                 

Gly Glu Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln 
305                 310                 315                 320 

Ala Gln Phe Gly Asn Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly 
                325                 330                 335     

Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
            340                 345                 350         

Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile 
        355                 360                 365             

Gly Pro Asn Asn Thr Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
    370                 375                 380                 

Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro 
385                 390                 395                 400 

Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
                405                 410                 415     

Leu Thr Arg Asp Gly Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe 
            420                 425                 430         

Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
        435                 440                 445             

Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
    450                 455                 460                 

Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg Ala Val Thr Leu Gly 
465                 470                 475                 480 

Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
                485                 490                 495     

Arg Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
            500                 505                 510         

Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
        515                 520                 525             

Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
    530                 535                 540                 

Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
545                 550                 555                 560 

Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala 
                565                 570                 575     

Ser Trp Ser Asn Lys Ser Leu Asp Gln Ile Trp Asn Asn Met Thr Trp 
            580                 585                 590         

Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asn Leu Ile Tyr Thr 
        595                 600                 605             

Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
    610                 615                 620                 

Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser 
625                 630                 635                 640 

Lys Trp Leu Trp Tyr Ile 
                645     

<210>   40
<211>   627
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   40
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Ser Phe Lys Val Thr Thr Ser Ile Arg Asn Lys Met Gln Lys Glu Tyr 
    130                 135                 140                 

Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr 
145                 150                 155                 160 

Ser Tyr Lys Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
                165                 170                 175     

Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
            180                 185                 190         

Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly 
        195                 200                 205             

Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
    210                 215                 220                 

Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly 
225                 230                 235                 240 

Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile 
                245                 250                 255     

Val Gln Leu Lys Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
            260                 265                 270         

Asn Thr Arg Gly Ala Gly Gln Ala His Cys Asn Ile Ser Gly Glu Lys 
        275                 280                 285             

Trp Asn Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln Ala Gln Phe 
    290                 295                 300                 

Gly Asn Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu 
305                 310                 315                 320 

Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn 
                325                 330                 335     

Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile Gly Pro Asn 
            340                 345                 350         

Asn Thr Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile 
        355                 360                 365             

Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg 
    370                 375                 380                 

Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg 
385                 390                 395                 400 

Asp Gly Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe Arg Pro Gly 
                405                 410                 415     

Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys 
            420                 425                 430         

Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg 
        435                 440                 445             

Arg Val Val Gln Arg Glu Lys Arg Ala Val Thr Leu Gly Ala Met Phe 
    450                 455                 460                 

Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala Arg Ser Leu 
465                 470                 475                 480 

Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln 
                485                 490                 495     

Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln 
            500                 505                 510         

Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val Leu Ala Val 
        515                 520                 525             

Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser 
    530                 535                 540                 

Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser 
545                 550                 555                 560 

Asn Lys Ser Leu Asp Gln Ile Trp Asn Asn Met Thr Trp Met Glu Trp 
                565                 570                 575     

Glu Arg Glu Ile Asp Asn Tyr Thr Asn Leu Ile Tyr Thr Leu Ile Glu 
            580                 585                 590         

Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu 
        595                 600                 605             

Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser Lys Trp Leu 
    610                 615                 620                 

Trp Tyr Ile 
625         

<210>   41
<211>   600
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   41
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Ser Phe Lys Val Gly Ala Gly Lys Leu Ile Asn Cys Asn Thr Ser Val 
    130                 135                 140                 

Ile Thr Gln Ala Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His 
145                 150                 155                 160 

Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys 
                165                 170                 175     

Phe Asn Gly Ser Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr 
            180                 185                 190         

His Gly Ile Arg Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser 
        195                 200                 205             

Leu Ala Glu Glu Gly Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn 
    210                 215                 220                 

Ala Lys Thr Ile Ile Val Gln Leu Lys Glu Ser Val Glu Ile Asn Cys 
225                 230                 235                 240 

Thr Arg Pro Asn Asn Asn Thr Arg Gly Ala Gly Gln Ala His Cys Asn 
                245                 250                 255     

Ile Ser Gly Glu Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Thr Lys 
            260                 265                 270         

Leu Gln Ala Gln Phe Gly Asn Lys Thr Ile Val Phe Lys Gln Ser Ser 
        275                 280                 285             

Gly Gly Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu 
    290                 295                 300                 

Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Asn 
305                 310                 315                 320 

Thr Ile Gly Pro Asn Asn Thr Asn Gly Thr Ile Thr Leu Pro Cys Arg 
                325                 330                 335     

Ile Lys Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr 
            340                 345                 350         

Ala Pro Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly 
        355                 360                 365             

Leu Leu Leu Thr Arg Asp Gly Gly Lys Glu Ile Ser Asn Thr Thr Glu 
    370                 375                 380                 

Ile Phe Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu 
385                 390                 395                 400 

Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro 
                405                 410                 415     

Thr Lys Ala Ile Ser Ser Val Val Gln Ser Glu Lys Ser Ala Val Thr 
            420                 425                 430         

Leu Gly Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met 
        435                 440                 445             

Gly Ala Arg Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser 
    450                 455                 460                 

Gly Ile Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln 
465                 470                 475                 480 

Gln His Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala 
                485                 490                 495     

Arg Val Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly 
            500                 505                 510         

Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp 
        515                 520                 525             

Asn Ala Ser Trp Ser Asn Lys Ser Leu Asp Gln Ile Trp Asn Asn Met 
    530                 535                 540                 

Thr Trp Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asn Leu Ile 
545                 550                 555                 560 

Tyr Thr Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln 
                565                 570                 575     

Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp 
            580                 585                 590         

Ile Ser Lys Trp Leu Trp Tyr Ile 
        595                 600 

<210>   42
<211>   13
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   42
Cys Ser Phe Lys Val Gly Ala Gly Lys Leu Ile Asn Cys 
1               5                   10              

<210>   43
<211>   646
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   43
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Ser Phe Lys Val Thr Thr Ser Ile Arg Asn Lys Met Gln Lys Glu Tyr 
    130                 135                 140                 

Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr 
145                 150                 155                 160 

Ser Tyr Lys Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
                165                 170                 175     

Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
            180                 185                 190         

Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly 
        195                 200                 205             

Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
    210                 215                 220                 

Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly 
225                 230                 235                 240 

Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile 
                245                 250                 255     

Val Gln Leu Lys Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
            260                 265                 270         

Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala 
        275                 280                 285             

Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
    290                 295                 300                 

Gly Glu Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln 
305                 310                 315                 320 

Ala Gln Phe Gly Asn Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly 
                325                 330                 335     

Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
            340                 345                 350         

Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile 
        355                 360                 365             

Gly Pro Asn Asn Thr Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
    370                 375                 380                 

Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro 
385                 390                 395                 400 

Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
                405                 410                 415     

Leu Thr Arg Asp Gly Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe 
            420                 425                 430         

Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
        435                 440                 445             

Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
    450                 455                 460                 

Ala Ile Ser Ser Val Val Gln Ser Glu Lys Ser Ala Val Thr Leu Gly 
465                 470                 475                 480 

Ala Met Phe Leu Gly Phe Leu Gly Ala Ala Gly Ser Thr Met Gly Ala 
                485                 490                 495     

Arg Ser Leu Thr Leu Thr Val Gln Ala Arg Gln Leu Leu Ser Gly Ile 
            500                 505                 510         

Val Gln Gln Gln Asn Asn Leu Leu Arg Ala Ile Glu Ala Gln Gln His 
        515                 520                 525             

Leu Leu Gln Leu Thr Val Trp Gly Ile Lys Gln Leu Gln Ala Arg Val 
    530                 535                 540                 

Leu Ala Val Glu Arg Tyr Leu Lys Asp Gln Gln Leu Leu Gly Ile Trp 
545                 550                 555                 560 

Gly Cys Ser Gly Lys Leu Ile Cys Thr Thr Ala Val Pro Trp Asn Ala 
                565                 570                 575     

Ser Trp Ser Asn Lys Ser Leu Asp Gln Ile Trp Asn Asn Met Thr Trp 
            580                 585                 590         

Met Glu Trp Glu Arg Glu Ile Asp Asn Tyr Thr Asn Leu Ile Tyr Thr 
        595                 600                 605             

Leu Ile Glu Glu Ser Gln Asn Gln Gln Glu Lys Asn Glu Gln Glu Leu 
    610                 615                 620                 

Leu Glu Leu Asp Lys Trp Ala Ser Leu Trp Asn Trp Phe Asp Ile Ser 
625                 630                 635                 640 

Lys Trp Leu Trp Tyr Ile 
                645     

<210>   44
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   44
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro 
1               5                   10                  15      

Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
            20                  25                  30          

Ala His Cys 
        35  

<210>   45
<211>   406
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<220>
<221>   Xaa
<222>   129, 231
<223>   Xaa is a mutant loop

<400>   45
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Xaa Cys Asn Thr Ser Val Ile Thr Gln Ala Cys Pro Lys Val Ser Phe 
    130                 135                 140                 

Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala Gly Phe Ala Ile Leu 
145                 150                 155                 160 

Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly Pro Cys Thr Asn Val 
                165                 170                 175     

Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro Val Val Ser Thr Gln 
            180                 185                 190         

Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly Val Val Ile Arg Ser 
        195                 200                 205             

Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile Val Gln Leu Lys Glu 
    210                 215                 220                 

Ser Val Glu Ile Asn Cys Xaa Cys Asn Ile Ser Gly Glu Lys Trp Asn 
225                 230                 235                 240 

Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln Ala Gln Phe Gly Asn 
                245                 250                 255     

Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly Asp Pro Glu Ile Val 
            260                 265                 270         

Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe Tyr Cys Asn Ser Thr 
        275                 280                 285             

Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile Gly Pro Asn Asn Thr 
    290                 295                 300                 

Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Arg 
305                 310                 315                 320 

Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Arg Gly Gln 
                325                 330                 335     

Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly 
            340                 345                 350         

Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe Arg Pro Gly Gly Gly 
        355                 360                 365             

Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val 
    370                 375                 380                 

Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val 
385                 390                 395                 400 

Val Gln Arg Glu Lys Arg 
                405     

<210>   46
<211>   35
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   46
Cys Thr Arg Pro Asn Asn Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro 
1               5                   10                  15      

Gly Arg Ala Phe Tyr Ala Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln 
            20                  25                  30          

Ala His Cys 
        35  

<210>   47
<211>   27
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   47
Met Arg Val Lys Gly Ile Arg Lys Asn Tyr Gln His Leu Trp Arg Gly 
1               5                   10                  15      

Gly Thr Leu Leu Leu Gly Met Leu Met Ile Cys 
            20                  25          

<210>   48
<211>   22
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   48
Met Asp Ala Met Lys Arg Gly Leu Cys Cys Val Leu Leu Leu Cys Gly 
1               5                   10                  15      

Ala Val Phe Val Ser Pro 
            20          

<210>   49
<211>   654
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   49
Ser Ala Thr Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Val Val Leu Val Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asp Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Ser Leu Lys Cys Thr Asp Leu Lys Asn Asp Thr Asn Thr 
            100                 105                 110         

Asn Ser Ser Ser Gly Arg Met Ile Met Glu Lys Gly Glu Ile Lys Asn 
        115                 120                 125             

Cys Ser Phe Asn Ile Ser Thr Ser Ile Arg Gly Lys Val Gln Lys Glu 
    130                 135                 140                 

Tyr Ala Phe Phe Tyr Lys Leu Asp Ile Ile Pro Ile Asp Asn Asp Thr 
145                 150                 155                 160 

Thr Ser Tyr Lys Leu Thr Ser Cys Asn Thr Ser Val Ile Thr Gln Ala 
                165                 170                 175     

Cys Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro 
            180                 185                 190         

Ala Gly Phe Ala Ile Leu Lys Cys Asn Asn Lys Thr Phe Asn Gly Thr 
        195                 200                 205             

Gly Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg 
    210                 215                 220                 

Pro Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu 
225                 230                 235                 240 

Glu Val Val Ile Arg Ser Val Asn Phe Thr Asp Asn Ala Lys Thr Ile 
                245                 250                 255     

Ile Val Gln Leu Asn Thr Ser Val Glu Ile Asn Cys Thr Arg Pro Asn 
            260                 265                 270         

Asn Asn Thr Arg Lys Arg Ile Arg Ile Gln Arg Gly Pro Gly Arg Ala 
        275                 280                 285             

Phe Val Thr Ile Gly Lys Ile Gly Asn Met Arg Gln Ala His Cys Asn 
    290                 295                 300                 

Ile Ser Arg Ala Lys Trp Asn Asn Thr Leu Lys Gln Ile Ala Ser Lys 
305                 310                 315                 320 

Leu Arg Glu Gln Phe Gly Asn Asn Lys Thr Ile Ile Phe Lys Gln Ser 
                325                 330                 335     

Ser Gly Gly Asp Pro Glu Ile Val Thr His Ser Phe Asn Cys Gly Gly 
            340                 345                 350         

Glu Phe Phe Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Phe 
        355                 360                 365             

Asn Ser Thr Trp Ser Thr Glu Gly Ser Asn Asn Thr Glu Gly Ser Asp 
    370                 375                 380                 

Thr Ile Thr Leu Pro Cys Arg Ile Lys Gln Ile Ile Asn Met Trp Gln 
385                 390                 395                 400 

Lys Val Gly Lys Ala Met Tyr Ala Pro Pro Ile Ser Gly Gln Ile Arg 
                405                 410                 415     

Cys Ser Ser Asn Ile Thr Gly Leu Leu Leu Thr Arg Asp Gly Gly Asn 
            420                 425                 430         

Ser Asn Asn Glu Ser Glu Ile Phe Arg Pro Gly Gly Gly Asp Met Arg 
        435                 440                 445             

Asp Asn Trp Arg Ser Glu Leu Tyr Lys Tyr Lys Val Val Lys Ile Glu 
    450                 455                 460                 

Pro Leu Gly Val Ala Pro Thr Lys Ala Lys Arg Arg Val Val Gln Arg 
465                 470                 475                 480 

Glu Lys Arg Ala Val Gly Ile Gly Ala Leu Phe Leu Gly Phe Leu Gly 
                485                 490                 495     

Ala Ala Gly Ser Thr Met Gly Ala Ala Ser Met Thr Leu Thr Val Gln 
            500                 505                 510         

Ala Arg Gln Leu Leu Ser Gly Ile Val Gln Gln Gln Asn Asn Leu Leu 
        515                 520                 525             

Arg Ala Ile Glu Ala Gln Gln His Leu Leu Gln Leu Thr Val Trp Gly 
    530                 535                 540                 

Ile Lys Gln Leu Gln Ala Arg Ile Leu Ala Val Glu Arg Tyr Leu Lys 
545                 550                 555                 560 

Asp Gln Gln Leu Leu Gly Ile Trp Gly Cys Ser Gly Lys Leu Ile Cys 
                565                 570                 575     

Thr Thr Ala Val Pro Trp Asn Ala Ser Trp Ser Asn Lys Ser Leu Glu 
            580                 585                 590         

Gln Ile Trp Asn His Thr Thr Trp Met Glu Trp Asp Arg Glu Ile Asn 
        595                 600                 605             

Asn Tyr Thr Ser Leu Ile His Ser Leu Ile Glu Glu Ser Gln Asn Gln 
    610                 615                 620                 

Gln Glu Lys Asn Glu Gln Glu Leu Leu Glu Leu Asp Lys Trp Ala Ser 
625                 630                 635                 640 

Leu Trp Asn Trp Phe Asn Ile Thr Asn Trp Leu Trp Tyr Ile 
                645                 650                 

<210>   50
<211>   475
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   50
Ser Ala Val Glu Lys Leu Trp Val Thr Val Tyr Tyr Gly Val Pro Val 
1               5                   10                  15      

Trp Lys Glu Ala Thr Thr Thr Leu Phe Cys Ala Ser Asp Ala Lys Ala 
            20                  25                  30          

Tyr Asp Thr Glu Val His Asn Val Trp Ala Thr His Ala Cys Val Pro 
        35                  40                  45              

Thr Asp Pro Asn Pro Gln Glu Ile Val Leu Glu Asn Val Thr Glu Asn 
    50                  55                  60                  

Phe Asn Met Trp Lys Asn Asn Met Val Glu Gln Met His Glu Asp Ile 
65                  70                  75                  80  

Ile Ser Leu Trp Asp Gln Ser Leu Lys Pro Cys Val Lys Leu Thr Pro 
                85                  90                  95      

Leu Cys Val Thr Leu His Cys Thr Asn Leu Lys Asn Ala Thr Asn Thr 
            100                 105                 110         

Lys Ser Ser Asn Trp Lys Glu Met Asp Arg Gly Glu Ile Lys Asn Cys 
        115                 120                 125             

Ser Phe Lys Val Thr Thr Ser Ile Arg Asn Lys Met Gln Lys Glu Tyr 
    130                 135                 140                 

Ala Leu Phe Tyr Lys Leu Asp Val Val Pro Ile Asp Asn Asp Asn Thr 
145                 150                 155                 160 

Ser Tyr Lys Leu Ile Asn Cys Asn Thr Ser Val Ile Thr Gln Ala Cys 
                165                 170                 175     

Pro Lys Val Ser Phe Glu Pro Ile Pro Ile His Tyr Cys Ala Pro Ala 
            180                 185                 190         

Gly Phe Ala Ile Leu Lys Cys Asn Asp Lys Lys Phe Asn Gly Ser Gly 
        195                 200                 205             

Pro Cys Thr Asn Val Ser Thr Val Gln Cys Thr His Gly Ile Arg Pro 
    210                 215                 220                 

Val Val Ser Thr Gln Leu Leu Leu Asn Gly Ser Leu Ala Glu Glu Gly 
225                 230                 235                 240 

Val Val Ile Arg Ser Glu Asn Phe Thr Asp Asn Ala Lys Thr Ile Ile 
                245                 250                 255     

Val Gln Leu Lys Glu Ser Val Glu Ile Asn Cys Thr Arg Pro Asn Asn 
            260                 265                 270         

Asn Thr Arg Lys Ser Ile Thr Ile Gly Pro Gly Arg Ala Phe Tyr Ala 
        275                 280                 285             

Thr Gly Asp Ile Ile Gly Asp Ile Arg Gln Ala His Cys Asn Ile Ser 
    290                 295                 300                 

Gly Glu Lys Trp Asn Asn Thr Leu Lys Gln Ile Val Thr Lys Leu Gln 
305                 310                 315                 320 

Ala Gln Phe Gly Asn Lys Thr Ile Val Phe Lys Gln Ser Ser Gly Gly 
                325                 330                 335     

Asp Pro Glu Ile Val Met His Ser Phe Asn Cys Gly Gly Glu Phe Phe 
            340                 345                 350         

Tyr Cys Asn Ser Thr Gln Leu Phe Asn Ser Thr Trp Asn Asn Thr Ile 
        355                 360                 365             

Gly Pro Asn Asn Thr Asn Gly Thr Ile Thr Leu Pro Cys Arg Ile Lys 
    370                 375                 380                 

Gln Ile Ile Asn Arg Trp Gln Glu Val Gly Lys Ala Met Tyr Ala Pro 
385                 390                 395                 400 

Pro Ile Arg Gly Gln Ile Arg Cys Ser Ser Asn Ile Thr Gly Leu Leu 
                405                 410                 415     

Leu Thr Arg Asp Gly Gly Lys Glu Ile Ser Asn Thr Thr Glu Ile Phe 
            420                 425                 430         

Arg Pro Gly Gly Gly Asp Met Arg Asp Asn Trp Arg Ser Glu Leu Tyr 
        435                 440                 445             

Lys Tyr Lys Val Val Lys Ile Glu Pro Leu Gly Val Ala Pro Thr Lys 
    450                 455                 460                 

Ala Lys Arg Arg Val Val Gln Arg Glu Lys Arg 
465                 470                 475 

<210>   51
<211>   9
<212>   PRT
<213>   Human immunodeficiency virus HIV-I

<400>   51
Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   

