                         SEQUENCE LISTING

<110>  The John's Hopkins University
       Chen, Lieping
 
<120>  B7-DC Variants

<130>  JHU D10161

<160>  12    

<170>  PatentIn version 3.3

<210>  1
<211>  273
<212>  PRT
<213>  Homo Sapien

<400>  1

Met Ile Phe Leu Leu Leu Met Leu Ser Leu Glu Leu Gln Leu His Gln 
1               5                   10                  15      


Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu Leu Tyr Ile Ile 
            20                  25                  30          


Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe Asp Thr Gly Ser 
        35                  40                  45              


His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val Gln Val Arg Asp 
                85                  90                  95      


Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg Lys Ile Asn Thr 
        115                 120                 125             


His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu Leu Thr Cys Gln 
    130                 135                 140                 


Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg Asn Phe Ser Cys 
            180                 185                 190         


Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu Ala Ser Ile Asp 
        195                 200                 205             


Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr Trp Leu Leu His 
    210                 215                 220                 


Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe Ile Ala Thr Val 
225                 230                 235                 240 


Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr Ser Ser Lys Asp 
                245                 250                 255     


Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu Val Asn Ser Ala 
            260                 265                 270         


Ile 
    


<210>  2
<211>  247
<212>  PRT
<213>  Mus musculus

<400>  2

Met Leu Leu Leu Leu Pro Ile Leu Asn Leu Ser Leu Gln Leu His Pro 
1               5                   10                  15      


Val Ala Ala Leu Phe Thr Val Thr Ala Pro Lys Glu Val Tyr Thr Val 
            20                  25                  30          


Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp Phe Asp Arg Arg Glu 
        35                  40                  45              


Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu Gln Lys Val Glu Asn 
    50                  55                  60                  


Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu Leu Glu Glu Gln Leu 
65                  70                  75                  80  


Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser Val Gln Val Arg Asp 
                85                  90                  95      


Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly Ala Ala Trp Asp Tyr 
            100                 105                 110         


Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr Met Arg Ile Asp Thr 
        115                 120                 125             


Arg Ile Leu Glu Val Pro Gly Thr Gly Glu Val Gln Leu Thr Cys Gln 
    130                 135                 140                 


Ala Arg Gly Tyr Pro Leu Ala Glu Val Ser Trp Gln Asn Val Ser Val 
145                 150                 155                 160 


Pro Ala Asn Thr Ser His Ile Arg Thr Pro Glu Gly Leu Tyr Gln Val 
                165                 170                 175     


Thr Ser Val Leu Arg Leu Lys Pro Gln Pro Ser Arg Asn Phe Ser Cys 
            180                 185                 190         


Met Phe Trp Asn Ala His Met Lys Glu Leu Thr Ser Ala Ile Ile Asp 
        195                 200                 205             


Pro Leu Ser Arg Met Glu Pro Lys Val Pro Arg Thr Trp Pro Leu His 
    210                 215                 220                 


Val Phe Ile Pro Ala Cys Thr Ile Ala Leu Ile Phe Leu Ala Ile Val 
225                 230                 235                 240 


Ile Ile Gln Arg Lys Arg Ile 
                245         


<210>  3
<211>  822
<212>  DNA
<213>  Homo Sapiens

<400>  3
atgatcttcc tcctgctaat gttgagcctg gaattgcagc ttcaccagat agcagcttta     60

ttcacagtga cagtccctaa ggaactgtac ataatagagc atggcagcaa tgtgaccctg    120

gaatgcaact ttgacactgg aagtcatgtg aaccttggag caataacagc cagtttgcaa    180

aaggtggaaa atgatacatc cccacaccgt gaaagagcca ctttgctgga ggagcagctg    240

cccctaggga aggcctcgtt ccacatacct caagtccaag tgagggacga aggacagtac    300

caatgcataa tcatctatgg ggtcgcctgg gactacaagt acctgactct gaaagtcaaa    360

gcttcctaca ggaaaataaa cactcacatc ctaaaggttc cagaaacaga tgaggtagag    420

ctcacctgcc aggctacagg ttatcctctg gcagaagtat cctggccaaa cgtcagcgtt    480

cctgccaaca ccagccactc caggacccct gaaggcctct accaggtcac cagtgttctg    540

cgcctaaagc caccccctgg cagaaacttc agctgtgtgt tctggaatac tcacgtgagg    600

gaacttactt tggccagcat tgaccttcaa agtcagatgg aacccaggac ccatccaact    660

tggctgcttc acattttcat cccctcctgc atcattgctt tcattttcat agccacagtg    720

atagccctaa gaaaacaact ctgtcaaaag ctgtattctt caaaagacac aacaaaaaga    780

cctgtcacca caacaaagag ggaagtgaac agtgctatct ga                       822


<210>  4
<211>  744
<212>  DNA
<213>  Mus musculus

<400>  4
atgctgctcc tgctgccgat actgaacctg agcttacaac ttcatcctgt agcagcttta     60

ttcaccgtga cagcccctaa agaagtgtac accgtagacg tcggcagcag tgtgagcctg    120

gagtgcgatt ttgaccgcag agaatgcact gaactggaag ggataagagc cagtttgcag    180

aaggtagaaa atgatacgtc tctgcaaagt gaaagagcca ccctgctgga ggagcagctg    240

cccctgggaa aggctttgtt ccacatccct agtgtccaag tgagagattc cgggcagtac    300

cgttgcctgg tcatctgcgg ggccgcctgg gactacaagt acctgacggt gaaagtcaaa    360

gcttcttaca tgaggataga cactaggatc ctggaggttc caggtacagg ggaggtgcag    420

cttacctgcc aggctagagg ttatccccta gcagaagtgt cctggcaaaa tgtcagtgtt    480

cctgccaaca ccagccacat caggaccccc gaaggcctct accaggtcac cagtgttctg    540

cgcctcaagc ctcagcctag cagaaacttc agctgcatgt tctggaatgc tcacatgaag    600

gagctgactt cagccatcat tgaccctctg agtcggatgg aacccaaagt ccccagaacg    660

tggccacttc atgttttcat cccggcctgc accatcgctt tgatcttcct ggccatagtg    720

ataatccaga gaaagaggat ctag                                           744


<210>  5
<211>  109
<212>  PRT
<213>  Homo sapiens

<400>  5

Leu Lys Ile Gln Ala Tyr Phe Asn Glu Thr Ala Asp Leu Pro Cys Gln 
1               5                   10                  15      


Phe Ala Asn Ser Gln Asn Gln Ser Leu Ser Glu Leu Val Val Phe Trp 
            20                  25                  30          


Gln Asp Gln Glu Asn Leu Val Leu Asn Glu Val Tyr Leu Gly Lys Glu 
        35                  40                  45              


Lys Phe Asp Ser Val His Ser Lys Tyr Met Gly Arg Thr Ser Phe Asp 
    50                  55                  60                  


Ser Asp Ser Trp Thr Leu Arg Leu His Asn Leu Gln Ile Lys Asp Lys 
65                  70                  75                  80  


Gly Leu Tyr Gln Cys Ile Ile His His Lys Lys Pro Thr Cys Met Ile 
                85                  90                  95      


Arg Ile His Gln Met Asn Ser Glu Leu Ser Val Leu Ala 
            100                 105                 


<210>  6
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  6

Ile His Val Thr Lys Glu Val Lys Glu Val Ala Thr Leu Ser Cys Gly 
1               5                   10                  15      


His Asn Val Ser Val Glu Glu Leu Ala Gln Thr Arg Ile Tyr Trp Gln 
            20                  25                  30          


Lys Glu Lys Lys Met Val Leu Thr Met Met Ser Gly Asp Met Asn Ile 
        35                  40                  45              


Trp Pro Glu Tyr Lys Asn Arg Thr Ile Phe Asp Ile Thr Asn Asn Leu 
    50                  55                  60                  


Ser Ile Val Ile Leu Ala Leu Arg Pro Ser Asp Glu Gly Thr Tyr Glu 
65                  70                  75                  80  


Cys Val Val Leu Lys Tyr Glu Lys Asp Ala Phe Lys Arg Glu His Leu 
                85                  90                  95      


Ala Glu Val Thr Leu Ser Val Lys Ala 
            100                 105 


<210>  7
<211>  113
<212>  PRT
<213>  homo sapiens

<400>  7

Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Met Thr Ile Glu Cys Lys 
1               5                   10                  15      


Phe Pro Val Glu Lys Gln Leu Asp Leu Ala Ala Leu Ile Val Tyr Trp 
            20                  25                  30          


Glu Met Glu Asp Lys Asn Ile Ile Gln Phe Val His Gly Glu Glu Asp 
        35                  40                  45              


Leu Lys Val Gln His Ser Ser Tyr Arg Gln Arg Ala Arg Leu Leu Lys 
    50                  55                  60                  


Asp Gln Leu Ser Leu Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys 
65                  70                  75                  80  


Leu Gln Asp Ala Gly Val Tyr Arg Cys Met Ile Ser Tyr Gly Gly Ala 
                85                  90                  95      


Asp Tyr Lys Arg Ile Thr Val Lys Val Asn Ala Pro Tyr Asn Lys Ile 
            100                 105                 110         


Asn 
    


<210>  8
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  8

Asp Leu Tyr Val Val Glu Tyr Gly Ser Asn Val Thr Met Glu Cys Arg 
1               5                   10                  15      


Phe Pro Val Glu Arg Glu Leu Asp Leu Leu Ala Leu Val Val Tyr Trp 
            20                  25                  30          


Glu Lys Glu Asp Glu Gln Val Ile Gln Phe Val Ala Gly Glu Glu Asp 
        35                  40                  45              


Leu Lys Pro Gln His Ser Asn Phe Arg Gly Arg Ala Ser Leu Pro Lys 
    50                  55                  60                  


Asp Gln Leu Leu Lys Gly Asn Ala Ala Leu Gln Ile Thr Asp Val Lys 
65                  70                  75                  80  


Leu Asp Asp Ala Gly Val Tyr Cys Cys Ile Ile Ser Tyr Gly Gly Ala 
                85                  90                  95      


Asp Tyr Lys Arg Ile Thr Leu Lys Val Asn Ala Pro Tyr Arg Lys Ile 
            100                 105                 110         


Asn 
    


<210>  9
<211>  114
<212>  PRT
<213>  homo sapiens

<400>  9

Lys Glu Val Arg Ala Met Val Gly Ser Asp Val Glu Leu Ser Cys Ala 
1               5                   10                  15      


Cys Pro Glu Gly Ser Arg Phe Asp Leu Asn Asp Val Tyr Val Tyr Trp 
            20                  25                  30          


Gln Thr Ser Glu Ser Lys Thr Val Val Thr Tyr His Ile Pro Gln Asn 
        35                  40                  45              


Ser Ser Leu Glu Asn Val Asp Ser Arg Tyr Arg Asn Arg Ala Leu Met 
    50                  55                  60                  


Ser Pro Ala Gly Leu Met Arg Gly Asp Phe Ser Leu Arg Leu Phe Asn 
65                  70                  75                  80  


Val Thr Pro Gln Asp Glu Gln Lys Phe His Cys Leu Val Leu Ser Gln 
                85                  90                  95      


Ser Leu Gly Phe Gln Glu Val Leu Ser Val Glu Val Thr Leu His Val 
            100                 105                 110         


Ala Ala 
        


<210>  10
<211>  110
<212>  PRT
<213>  homo sapiens

<400>  10

Asp Pro Val Val Ala Leu Val Gly Thr Asp Ala Thr Leu Cys Cys Ser 
1               5                   10                  15      


Pro Ser Pro Glu Pro Gly Phe Ser Leu Ala Gln Leu Asn Leu Ile Trp 
            20                  25                  30          


Gln Leu Thr Asp Thr Gln Leu Val His Ser Phe Ala Glu Gly Gln Asp 
        35                  40                  45              


Gln Gly Ser Ala Tyr Ala Asn Arg Thr Ala Leu Phe Pro Asp Leu Leu 
    50                  55                  60                  


Ala Gln Gly Asn Ala Ser Leu Arg Leu Gln Arg Val Arg Val Ala Asp 
65                  70                  75                  80  


Glu Gly Ser Phe Thr Cys Phe Val Ser Ile Arg Asp Phe Gly Ser Ala 
                85                  90                  95      


Ala Val Ser Leu Gln Val Ala Ala Pro Tyr Ser Lys Pro Ser 
            100                 105                 110 


<210>  11
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Leu Tyr Ile Ile Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn 
1               5                   10                  15      


Phe Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu 
            20                  25                  30          


Gln Lys Val Glu Asn Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu 
        35                  40                  45              


Leu Glu Glu Gln Leu Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln 
    50                  55                  60                  


Val Gln Val Arg Asp Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly 
65                  70                  75                  80  


Val Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr 
                85                  90                  95      


Arg Lys 
        


<210>  12
<211>  98
<212>  PRT
<213>  Mus Musculus

<400>  12

Glu Val Tyr Thr Val Asp Val Gly Ser Ser Val Ser Leu Glu Cys Asp 
1               5                   10                  15      


Phe Asp Arg Arg Glu Cys Thr Glu Leu Glu Gly Ile Arg Ala Ser Leu 
            20                  25                  30          


Gln Lys Val Glu Asn Asp Thr Ser Leu Gln Ser Glu Arg Ala Thr Leu 
        35                  40                  45              


Leu Glu Glu Gln Leu Pro Leu Gly Lys Ala Leu Phe His Ile Pro Ser 
    50                  55                  60                  


Val Gln Val Arg Asp Ser Gly Gln Tyr Arg Cys Leu Val Ile Cys Gly 
65                  70                  75                  80  


Ala Ala Trp Asp Tyr Lys Tyr Leu Thr Val Lys Val Lys Ala Ser Tyr 
                85                  90                  95      


Met Arg 
        


