                         SEQUENCE LISTING

<110>  MARKOWITZ, JOHN S.
       ZHU, HAOJIE
 
<120>  CARBOXYLESTERASE-1 POLYMORPHISMS AND METHODS OF USE THEREFOR

<130>  MESC:025WO

<140>  UNKNOWN
<141>  2008-06-10

<150>  61/053,524
<151>  2008-05-15

<150>  61/051,680
<151>  2008-05-09

<150>  60/942,818
<151>  2007-06-08

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  1
cccaggtgat ggtgtggat                                                  19


<210>  2
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  2
gccagcccat cataggttga                                                 20


<210>  3
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  3
ccatcagccc ccctc                                                      15


<210>  4
<211>  15
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  4
ccatcagctc ccctc                                                      15


<210>  5
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  5
tggccctcac ttctgttctg                                                 20


<210>  6
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  6
ccagccggag acctacct                                                   18


<210>  7
<211>  17
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  7
aaaggtgatg tcaagcc                                                    17


<210>  8
<211>  16
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  8
aaaggtgagt caagcc                                                     16


<210>  9
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  9
tgatgggagt gtcctcccga ag                                              22


<210>  10
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  10
gggtaggtag tgtgtccaat tac                                             23


<210>  11
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  11
aggaagactt ccacctcctt g                                               21


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  12
aggagtgtgg tcacacagat ag                                              22


<210>  13
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala 
            260                 265                 270         


Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg Gln 
        275                 280                 285             


Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe Leu 
    290                 295                 300                 


Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly 
305                 310                 315                 320 


Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln 
                325                 330                 335     


Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys 
            340                 345                 350         


Gln Glu Phe Gly Trp Leu Ile Pro Met Gln Leu Met Ser Tyr Pro Leu 
        355                 360                 365             


Ser Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp Lys 
    370                 375                 380                 


Ser Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr 
385                 390                 395                 400 


Glu Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp Leu 
                405                 410                 415     


Phe Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val Ile 
            420                 425                 430         


Val Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu 
        435                 440                 445             


Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr Val 
    450                 455                 460                 


Ile Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro Phe 
465                 470                 475                 480 


Leu Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val 
                485                 490                 495     


Met Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu 
            500                 505                 510         


Gly Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Tyr Leu Gln 
        515                 520                 525             


Ile Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val 
    530                 535                 540                 


Ala Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro 
545                 550                 555                 560 


Gln Thr Glu His Ile Glu Leu 
                565         


<210>  14
<211>  567
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Glu Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Asp Val Lys Pro Leu Ala Glu Gln Ile Ala Ile Thr Ala 
            260                 265                 270         


Gly Cys Lys Thr Thr Thr Ser Ala Val Met Val His Cys Leu Arg Gln 
        275                 280                 285             


Lys Thr Glu Glu Glu Leu Leu Glu Thr Thr Leu Lys Met Lys Phe Leu 
    290                 295                 300                 


Ser Leu Asp Leu Gln Gly Asp Pro Arg Glu Ser Gln Pro Leu Leu Gly 
305                 310                 315                 320 


Thr Val Ile Asp Gly Met Leu Leu Leu Lys Thr Pro Glu Glu Leu Gln 
                325                 330                 335     


Ala Glu Arg Asn Phe His Thr Val Pro Tyr Met Val Gly Ile Asn Lys 
            340                 345                 350         


Gln Glu Phe Gly Trp Leu Ile Pro Met Gln Leu Met Ser Tyr Pro Leu 
        355                 360                 365             


Ser Glu Gly Gln Leu Asp Gln Lys Thr Ala Met Ser Leu Leu Trp Lys 
    370                 375                 380                 


Ser Tyr Pro Leu Val Cys Ile Ala Lys Glu Leu Ile Pro Glu Ala Thr 
385                 390                 395                 400 


Glu Lys Tyr Leu Gly Gly Thr Asp Asp Thr Val Lys Lys Lys Asp Leu 
                405                 410                 415     


Phe Leu Asp Leu Ile Ala Asp Val Met Phe Gly Val Pro Ser Val Ile 
            420                 425                 430         


Val Ala Arg Asn His Arg Asp Ala Gly Ala Pro Thr Tyr Met Tyr Glu 
        435                 440                 445             


Phe Gln Tyr Arg Pro Ser Phe Ser Ser Asp Met Lys Pro Lys Thr Val 
    450                 455                 460                 


Ile Gly Asp His Gly Asp Glu Leu Phe Ser Val Phe Gly Ala Pro Phe 
465                 470                 475                 480 


Leu Lys Glu Gly Ala Ser Glu Glu Glu Ile Arg Leu Ser Lys Met Val 
                485                 490                 495     


Met Lys Phe Trp Ala Asn Phe Ala Arg Asn Gly Asn Pro Asn Gly Glu 
            500                 505                 510         


Gly Leu Pro His Trp Pro Glu Tyr Asn Gln Lys Glu Gly Thr Leu Gln 
        515                 520                 525             


Ile Gly Ala Asn Thr Gln Ala Ala Gln Lys Leu Lys Asp Lys Glu Val 
    530                 535                 540                 


Ala Phe Trp Thr Asn Leu Phe Ala Lys Lys Ala Val Glu Lys Pro Pro 
545                 550                 555                 560 


Gln Thr Glu His Ile Glu Leu 
                565         


<210>  15
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Trp Leu Arg Ala Phe Ile Leu Ala Thr Leu Ser Ala Ser Ala Ala 
1               5                   10                  15      


Trp Gly His Pro Ser Ser Pro Pro Val Val Asp Thr Val His Gly Lys 
            20                  25                  30          


Val Leu Gly Lys Phe Val Ser Leu Glu Gly Phe Ala Gln Pro Val Ala 
        35                  40                  45              


Ile Phe Leu Gly Ile Pro Phe Ala Lys Pro Pro Leu Gly Pro Leu Arg 
    50                  55                  60                  


Phe Thr Pro Pro Gln Pro Ala Glu Pro Trp Ser Phe Val Lys Asn Ala 
65                  70                  75                  80  


Thr Ser Tyr Pro Pro Met Cys Thr Gln Asp Pro Lys Ala Gly Gln Leu 
                85                  90                  95      


Leu Ser Glu Leu Phe Thr Asn Arg Lys Glu Asn Ile Pro Leu Lys Leu 
            100                 105                 110         


Ser Glu Asp Cys Leu Tyr Leu Asn Ile Tyr Thr Pro Ala Asp Leu Thr 
        115                 120                 125             


Lys Lys Asn Arg Leu Pro Val Met Val Trp Ile His Gly Gly Gly Leu 
    130                 135                 140                 


Met Val Gly Ala Ala Ser Thr Tyr Asp Gly Leu Ala Leu Ala Ala His 
145                 150                 155                 160 


Glu Asn Val Val Val Val Thr Ile Gln Tyr Arg Leu Gly Ile Trp Gly 
                165                 170                 175     


Phe Phe Ser Thr Gly Asp Glu His Ser Arg Gly Asn Trp Gly His Leu 
            180                 185                 190         


Asp Gln Val Ala Ala Leu Arg Trp Val Gln Asp Asn Ile Ala Ser Phe 
        195                 200                 205             


Gly Gly Asn Pro Gly Ser Val Thr Ile Phe Gly Glu Ser Ala Gly Gly 
    210                 215                 220                 


Glu Ser Val Ser Val Leu Val Leu Ser Pro Leu Ala Lys Asn Leu Phe 
225                 230                 235                 240 


His Arg Ala Ile Ser Glu Ser Gly Val Ala Leu Thr Ser Val Leu Val 
                245                 250                 255     


Lys Lys Gly Glu Ser Ser Pro Trp Leu Ser Lys Leu Leu Ser Leu Leu 
            260                 265                 270         


Gly Ala Lys Pro Pro Pro Leu Leu Ser Trp Phe Thr Ala Cys Asp Arg 
        275                 280                 285             


Arg Arg Lys Arg Ser Ser Trp Arg Arg His 
    290                 295             


