
                                SEQUENCE LISTING

<110> Abbott Laboratories
      Reilly, Edward B.
      Lacy, Susan E.
      Fung, Emma
      Belk, Johathan P.
      Roguska, Michael

<120> ANTIBODIES TO ERYTHROPOIETIN RECEPTOR
  AND USES THEREOF

<130> 7349USP2

<140> Not Yet Assigned    
<141> 2006-12-21  

<150> 60/561,084          
<151> 2004-04-09  

<150> 60/561,313          
<151> 2004-04-12  

<150> 11/102,424          
<151> 2005-08-04  

<160> 40

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv linker

<400> 1
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
 1               5                  10                  15  


<210> 2
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv linker

<400> 2
Gly Glu Asn Lys Val Glu Tyr Ala Pro Ala Leu Met Ala Leu Ser
 1               5                  10                  15  


<210> 3
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv linker

<400> 3
Gly Pro Ala Lys Glu Leu Thr Pro Leu Lys Glu Ala Lys Val Ser
 1               5                  10                  15  


<210> 4
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> scFv linker

<400> 4
Gly His Glu Ala Ala Ala Val Met Gln Val Gln Tyr Pro Ala Ser
 1               5                  10                  15  


<210> 5
<211> 116
<212> PRT
<213> Homo sapiens

<400> 5
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 6
<211> 116
<212> PRT
<213> Homo sapiens

<400> 6
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 7
<211> 116
<212> PRT
<213> Homo sapiens

<400> 7
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Gly Gly Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 8
<211> 116
<212> PRT
<213> Homo sapiens

<400> 8
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Ala Gly Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 9
<211> 116
<212> PRT
<213> Homo sapiens

<400> 9
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Gly Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 10
<211> 116
<212> PRT
<213> Homo sapiens

<400> 10
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Gly Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 11
<211> 116
<212> PRT
<213> Homo sapiens

<400> 11
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Tyr Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 12
<211> 116
<212> PRT
<213> Homo sapiens

<400> 12
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Gly Gly Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 13
<211> 116
<212> PRT
<213> Homo sapiens

<400> 13
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Tyr Gly Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 14
<211> 116
<212> PRT
<213> Homo sapiens

<400> 14
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Gly Tyr Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 15
<211> 116
<212> PRT
<213> Artificial Sequence

<220> 
<221> VARIANT        
<222> 52, 53, 54

<223> Xaa = Any Amino Acid; consensus sequence

<400> 15
Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Ala Ser Ile Ser Ser Tyr
            20                  25                  30          
Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ile Xaa Xaa Xaa Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu
65                  70                  75                  80  
Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Arg Leu Gly Ile Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val
            100                 105                 110         
Thr Val Ser Ser
        115     


<210> 16
<211> 107
<212> PRT
<213> Homo sapiens

<400> 16
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Ser Tyr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 17
<211> 107
<212> PRT
<213> Homo sapiens

<400> 17
Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg Asn Asp
            20                  25                  30          
Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Arg Leu Ile
        35                  40                  45              
Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Leu Gln His Asn Thr Tyr Pro Pro
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys
            100                 105         


<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<221> VARIANT        
<222> 3,4,5

<223> Xaa = Any Amino Acid; heavy chain variable region

<400> 18
Tyr Ile Xaa Xaa Xaa Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 19
<211> 16
<212> PRT
<213> Homo sapiens

<400> 19
Tyr Ile Gly Gly Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 20
<211> 16
<212> PRT
<213> Homo sapiens

<400> 20
Tyr Ile Ala Gly Thr Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 21
<211> 16
<212> PRT
<213> Homo sapiens

<400> 21
Tyr Ile Gly Tyr Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 22
<211> 16
<212> PRT
<213> Homo sapiens

<400> 22
Tyr Ile Tyr Gly Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 23
<211> 16
<212> PRT
<213> Homo sapiens

<400> 23
Tyr Ile Tyr Tyr Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 24
<211> 16
<212> PRT
<213> Homo sapiens

<400> 24
Tyr Ile Gly Gly Ser Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 25
<211> 16
<212> PRT
<213> Homo sapiens

<400> 25
Tyr Ile Tyr Gly Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 26
<211> 16
<212> PRT
<213> Homo sapiens

<400> 26
Tyr Ile Gly Tyr Glu Gly Ser Thr Asn Tyr Asn Pro Ser Leu Lys Ser
 1               5                  10                  15      


<210> 27
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Linker sequence

<400> 27
Gly Phe Lys Asp Ala Leu Lys Gln Pro Met Pro Tyr Ala Thr Ser
 1               5                  10                  15  


<210> 28
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<221> variation      
<222> 4 - 19, 21 - 42

<223> n = A,T,C or G; h = A,C or T; s = C or G; linker
      sequence

<400> 28
gganhsnhsn hsnhsnhsnh snhsnhsnhs nhsnhsnhsn hsagt                 45

<210> 29
<211> 45
<212> DNA
<213> Artificial Sequence

<220> 
<221> variation      
<222> 4 - 19, 21 - 42

<223> n = A,T,C or G; s = C or G; v = A, C or G

<400> 29
ggavnsvnsv nsvnsvnsvn svnsvnsvns vnsvnsvnsv nsagt                 45

<210> 30
<211> 348
<212> DNA
<213> Homo sapiens

<400> 30
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atctatggca gtgggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 31
<211> 348
<212> DNA
<213> Homo sapiens

<400> 31
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atctattacg aagggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 32
<211> 348
<212> DNA
<213> Homo sapiens

<400> 32
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atcggggggt cggggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 33
<211> 348
<212> DNA
<213> Homo sapiens

<400> 33
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atctatgggg aagggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 34
<211> 348
<212> DNA
<213> Homo sapiens

<400> 34
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atcgggtacg aggggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 35
<211> 321
<212> DNA
<213> Homo sapiens

<400> 35
gacatccagc tgacccaatc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60
atcacttgcc gggcaagtca gggcattaga aatgatttag gctggtatca gcagaaacca 120
gggaaagccc ctaagcgcct gatctatgct gcatccagtt tgcaaagtgg ggtcccatca 180
aggttcagcg gcagtggatc tgggacagaa ttcactctca caatcagcag cctgcagcct 240
gaagattttg caacttatta ctgtctacag cataatactt accctccgac gttcggccaa 300
gggaccaagg tggaaatcaa a                                           321

<210> 36
<211> 348
<212> DNA
<213> Homo sapiens

<400> 36
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atctattaca gtgggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 37
<211> 348
<212> DNA
<213> Homo sapiens

<400> 37
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atcggggggg aggggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 38
<211> 348
<212> DNA
<213> Homo sapiens

<400> 38
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atcgccggga cggggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 39
<211> 348
<212> DNA
<213> Homo sapiens

<400> 39
caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60
acctgcactg tctctggtgc ctccatcagt agttactact ggagctggat ccggcagccc 120
ccagggaagg gactggagtg gattgggtat atcggttaca gtgggagcac caactacaac 180
ccctccctca agagtcgagt caccatatca gtagacacgt ccaagaacca gttctccctg 240
aagctgaggt ctgtgaccgc tgcggacacg gccgtgtatt actgtgcgag agagcgactg 300
gggatcgggg actactgggg ccagggaacc ctggtcaccg tctcctca              348

<210> 40
<211> 248
<212> PRT
<213> Homo sapiens

<400> 40
Met Gly Ser Ser His His His His His His Ser Ser Gly Leu Val Pro
 1               5                  10                  15      
Arg Gly Ser Gly Met Ala Pro Pro Pro Asn Leu Pro Asp Pro Lys Phe
            20                  25                  30          
Glu Ser Lys Ala Ala Leu Leu Ala Ala Arg Gly Pro Glu Glu Leu Leu
        35                  40                  45              
Cys Phe Thr Glu Arg Leu Glu Asp Leu Val Cys Phe Trp Glu Glu Ala
    50                  55                  60                  
Ala Ser Ala Gly Val Gly Pro Gly Asn Tyr Ser Phe Ser Tyr Gln Leu
65                  70                  75                  80  
Glu Asp Glu Pro Trp Lys Leu Cys Arg Leu His Gln Ala Pro Thr Ala
                85                  90                  95      
Arg Gly Ala Val Arg Phe Trp Cys Ser Leu Pro Thr Ala Asp Thr Ser
            100                 105                 110         
Ser Phe Val Pro Leu Glu Leu Arg Val Thr Ala Ala Ser Gly Ala Pro
        115                 120                 125             
Arg Tyr His Arg Val Ile His Ile Asn Glu Val Val Leu Leu Asp Ala
    130                 135                 140                 
Pro Val Gly Leu Val Ala Arg Leu Ala Asp Glu Ser Gly His Val Val
145                 150                 155                 160 
Leu Arg Trp Leu Pro Pro Pro Glu Thr Pro Met Thr Ser His Ile Arg
                165                 170                 175     
Tyr Glu Val Asp Val Ser Ala Gly Asn Gly Ala Gly Ser Val Gln Arg
            180                 185                 190         
Val Glu Ile Leu Glu Gly Arg Thr Glu Cys Val Leu Ser Asn Leu Arg
        195                 200                 205             
Gly Arg Thr Arg Tyr Thr Phe Ala Val Arg Ala Arg Met Ala Glu Pro
    210                 215                 220                 
Ser Phe Gly Gly Phe Trp Ser Ala Trp Ser Glu Pro Val Ser Leu Leu
225                 230                 235                 240 
Thr Pro Ser Asp Leu Asp Leu Glu
                245             

