                               SEQUENCE LISTING                               

<110> CHILDREN'S MEDICAL CENTER CORPORATION

<120> TREATMENT OF AIRWAY HYPERREACTIVITY

<130> 701039-060231-PCT

<140> 
<141> 

<150> 60/957,011
<151> 2007-08-21

<160> 6                             

<170> PatentIn Ver. 3.5

<210> 1
<211> 3429
<212> DNA
<213> Homo sapiens

<400> 1
ctgggcccgg gctggaagcc ggaagcgagc aaagtggagc cgactcgaac tccaccgcgg 60    
aaaagaaagc ctcagaacgt tcgttcgctg cgtccccagc cggggccgag ccctccgcga 120   
cgccagccgg gccatggggg ccgcacgcag cccgccgtcc gctgtcccgg ggcccctgct 180   
ggggctgctc ctgctgctcc tgggcgtgct ggccccgggt ggcgcctccc tgcgactcct 240   
ggaccaccgg gcgctggtct gctcccagcc ggggctaaac tgcacggtca agaatagtac 300   
ctgcctggat gacagctgga ttcaccctcg aaacctgacc ccctcctccc caaaggacct 360   
gcagatccag ctgcactttg cccacaccca acaaggagac ctgttccccg tggctcacat 420   
cgaatggaca ctgcagacag acgccagcat cctgtacctc gagggtgcag agttatctgt 480   
cctgcagctg aacaccaatg aacgtttgtg cgtcaggttt gagtttctgt ccaaactgag 540   
gcatcaccac aggcggtggc gttttacctt cagccacttt gtggttgacc ctgaccagga 600   
atatgaggtg accgttcacc acctgcccaa gcccatccct gatggggacc caaaccacca 660   
gtccaagaat ttccttgtgc ctgactgtga gcacgccagg atgaaggtaa ccacgccatg 720   
catgagctca ggcagcctgt gggaccccaa catcaccgtg gagaccctgg aggcccacca 780   
gctgcgtgtg agcttcaccc tgtggaacga atctacccat taccagatcc tgctgaccag 840   
ttttccgcac atggagaacc acagttgctt tgagcacatg caccacatac ctgcgcccag 900   
accagaagag ttccaccagc gatccaacgt cacactcact ctacgcaacc ttaaagggtg 960   
ctgtcgccac caagtgcaga tccagccctt cttcagcagc tgcctcaatg actgcctcag 1020  
acactccgcg actgtttcct gcccagaaat gccagacact ccagaaccaa ttccggacta 1080  
catgcccctg tgggtgtact ggttcatcac gggcatctcc atcctgctgg tgggctccgt 1140  
catcctgctc atcgtctgca tgacctggag gctagctggg cctggaagtg aaaaatacag 1200  
tgatgacacc aaatacaccg atggcctgcc tgcggctgac ctgatccccc caccgctgaa 1260  
gcccaggaag gtctggatca tctactcagc cgaccacccc ctctacgtgg acgtggtcct 1320  
gaaattcgcc cagttcctgc tcaccgcctg cggcacggaa gtggccctgg acctgctgga 1380  
agagcaggcc atctcggagg caggagtcat gacctgggtg ggccgtcaga agcaggagat 1440  
ggtggagagc aactctaaga tcatcgtcct gtgctcccgc ggcacgcgcg ccaagtggca 1500  
ggcgctcctg ggccgggggg cgcctgtgcg gctgcgctgc gaccacggaa agcccgtggg 1560  
ggacctgttc actgcagcca tgaacatgat cctcccggac ttcaagaggc cagcctgctt 1620  
cggcacctac gtagtctgct acttcagcga ggtcagctgt gacggcgacg tccccgacct 1680  
gttcggcgcg gcgccgcggt acccgctcat ggacaggttc gaggaggtgt acttccgcat 1740  
ccaggacctg gagatgttcc agccgggccg catgcaccgc gtaggggagc tgtcggggga 1800  
caactacctg cggagcccgg gcggcaggca gctccgcgcc gccctggaca ggttccggga 1860  
ctggcaggtc cgctgtcccg actggttcga atgtgagaac ctctactcag cagatgacca 1920  
ggatgccccg tccctggacg aagaggtgtt tgaggagcca ctgctgcctc cgggaaccgg 1980  
catcgtgaag cgggcgcccc tggtgcgcga gcctggctcc caggcctgcc tggccataga 2040  
cccgctggtc ggggaggaag gaggagcagc agtggcaaag ctggaacctc acctgcagcc 2100  
ccggggtcag ccagcgccgc agcccctcca caccctggtg ctcgccgcag aggagggggc 2160  
cctggtggcc gcggtggagc ctgggcccct ggctgacggt gccgcagtcc ggctggcact 2220  
ggcgggggag ggcgaggcct gcccgctgct gggcagcccg ggcgctgggc gaaatagcgt 2280  
cctcttcctc cccgtggacc ccgaggactc gccccttggc agcagcaccc ccatggcgtc 2340  
tcctgacctc cttccagagg acgtgaggga gcacctcgaa ggcttgatgc tctcgctctt 2400  
cgagcagagt ctgagctgcc aggcccaggg gggctgcagt agacccgcca tggtcctcac 2460  
agacccacac acgccctacg aggaggagca gcggcagtca gtgcagtctg accagggcta 2520  
catctccagg agctccccgc agccccccga gggactcacg gaaatggagg aagaggagga 2580  
agaggagcag gacccaggga agccggccct gccactctct cccgaggacc tggagagcct 2640  
gaggagcctc cagcggcagc tgcttttccg ccagctgcag aagaactcgg gctgggacac 2700  
gatggggtca gagtcagagg ggcccagtgc atgagggcgg ctccccaggg accgcccaga 2760  
tcccagcttt gagagaggag tgtgtgtgca cgtattcatc tgtgtgtaca tgtctgcatg 2820  
tgtatatgtt cgtgtgtgaa atgtaggctt taaaatgtaa atgtctggat tttaatccca 2880  
ggcatccctc ctaacttttc tttgtgcagc ggtctggtta tcgtctatcc ccaggggaat 2940  
ccacacagcc cgctcccagg agctaatggt agagcgtcct tgaggctcca ttattcgttc 3000  
attcagcatt tattgtgcac ctactatgtg gcgggcattt gggataccaa gataaattgc 3060  
atgcggcatg gccccagcca tgaaggaact taaccgctag tgccgaggac acgttaaacg 3120  
aacaggatgg gccgggcacg gtggctcacg cctgtaatcc cagcacactg ggaggccgag 3180  
gcaggtggat cactctgagg tcaggagttt gagccagcct ggccaacatg gtgaaacccc 3240  
atctccacta aaaatagaaa aattagccgg gcatggtgac acatgcctgt agtcctagct 3300  
acttgggagg ctgaggcagg agaattgctt gaatctggga ggcagaggtt gcagtgagcc 3360  
gagattgtgc cattgcactg cagcctggat gacagagcga gactctatct caaaaaaaaa 3420  
aaaaaaaaa                                                         3429  


<210> 2
<211> 866
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu  
  1               5                  10                  15    

Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser  
             20                  25                  30        

Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu  
         35                  40                  45            

Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His  
     50                  55                  60                

Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu  
 65                  70                  75                  80

His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile  
                 85                  90                  95    

Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala  
            100                 105                 110        

Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg  
        115                 120                 125            

Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe  
    130                 135                 140                

Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr  
145                 150                 155                 160

Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln  
                165                 170                 175    

Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val  
            180                 185                 190        

Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr  
        195                 200                 205            

Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp  
    210                 215                 220                

Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met  
225                 230                 235                 240

Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg  
                245                 250                 255    

Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn  
            260                 265                 270        

Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser  
        275                 280                 285            

Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro  
    290                 295                 300                

Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp  
305                 310                 315                 320

Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val  
                325                 330                 335    

Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser  
            340                 345                 350        

Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala  
        355                 360                 365            

Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr  
    370                 375                 380                

Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln  
385                 390                 395                 400

Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu  
                405                 410                 415    

Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln  
            420                 425                 430        

Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser  
        435                 440                 445            

Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro  
    450                 455                 460                

Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr  
465                 470                 475                 480

Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe  
                485                 490                 495    

Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp  
            500                 505                 510        

Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg  
        515                 520                 525            

Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro  
    530                 535                 540                

Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg  
545                 550                 555                 560

Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp  
                565                 570                 575    

Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser  
            580                 585                 590        

Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu  
        595                 600                 605            

Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val  
    610                 615                 620                

Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly  
625                 630                 635                 640

Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro  
                645                 650                 655    

Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala  
            660                 665                 670        

Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp  
        675                 680                 685            

Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro  
    690                 695                 700                

Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro  
705                 710                 715                 720

Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser  
                725                 730                 735    

Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met  
            740                 745                 750        

Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys  
        755                 760                 765            

Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu  
    770                 775                 780                

Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser  
785                 790                 795                 800

Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu  
                805                 810                 815    

Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp  
            820                 825                 830        

Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu  
        835                 840                 845            

Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro  
    850                 855                 860                

Ser Ala                                                          
865    


<210> 3
<211> 155
<212> PRT
<213> Homo sapiens

<400> 3
Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser  
  1               5                  10                  15    

Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly  
             20                  25                  30        

Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn  
         35                  40                  45            

Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser  
     50                  55                  60                

Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu  
 65                  70                  75                  80

Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His  
                 85                  90                  95    

Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser  
            100                 105                 110        

Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His  
        115                 120                 125            

Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys  
    130                 135                 140                

Thr Cys Val Thr Pro Ile Val His His Val Ala                      
145                 150                 155


<210> 4
<211> 1859
<212> DNA
<213> Homo sapiens

<400> 4
gcaggcacaa actcatccat ccccagttga ttggaagaaa caacgatgac tcctgggaag 60    
acctcattgg tgtcactgct actgctgctg agcctggagg ccatagtgaa ggcaggaatc 120   
acaatcccac gaaatccagg atgcccaaat tctgaggaca agaacttccc ccggactgtg 180   
atggtcaacc tgaacatcca taaccggaat accaatacca atcccaaaag gtcctcagat 240   
tactacaacc gatccacctc accttggaat ctccaccgca atgaggaccc tgagagatat 300   
ccctctgtga tctgggaggc aaagtgccgc cacttgggct gcatcaacgc tgatgggaac 360   
gtggactacc acatgaactc tgtccccatc cagcaagaga tcctggtcct gcgcagggag 420   
cctccacact gccccaactc cttccggctg gagaagatac tggtgtccgt gggctgcacc 480   
tgtgtcaccc cgattgtcca ccatgtggcc taagagctct ggggagccca cactccccaa 540   
agcagttaga ctatggagag ccgacccagc ccctcaggaa ccctcatcct tcaaagacag 600   
cctcatttcg gactaaactc attagagttc ttaaggcagt ttgtccaatt aaagcttcag 660   
aggtaacact tggccaagat atgagatctg aattaccttt ccctctttcc aagaaggaag 720   
gtttgactga gtaccaattt gcttcttgtt tactttttta agggctttaa gttatttatg 780   
tatttaatat gccctgagat aactttgggg tataagattc cattttaatg aattacctac 840   
tttattttgt ttgtcttttt aaagaagata agattctggg cttgggaatt ttattattta 900   
aaaggtaaaa cctgtattta tttgagctat ttaaggatct atttatgttt aagtatttag 960   
aaaaaggtga aaaagcacta ttatcagttc tgcctaggta aatgtaagat agaattaaat 1020  
ggcagtgcaa aatttctgag tctttacaac atacggatat agtatttcct cctctttgtt 1080  
tttaaaagtt ataacatggc tgaaaagaaa gattaaacct actttcatat gtattaattt 1140  
aaattttgca atttgttgag gttttacaag agatacagca agtctaactc tctgttccat 1200  
taaaccctta taataaaatc cttctgtaat aataaagttt caaaagaaaa tgtttatttg 1260  
ttctcattaa atgtatttta gcaaactcag ctcttcccta ttgggaagag ttatgcaaat 1320  
tctcctataa gcaaaacaaa gcatgtcttt gagtaacaat gacctggaaa tacccaaaat 1380  
tccaagttct cgatttcaca tgccttcaag actgaacacc gactaaggtt ttcatactat 1440  
tagccaatgc tgtagacaga agcattttga taggaataga gcaaataaga taatggccct 1500  
gaggaatggc atgtcattat taaagatcat atggggaaaa tgaaaccctc cccaaaatac 1560  
aagaagttct gggaggagac attgtcttca gactacaatg tccagtttct cccctagact 1620  
caggcttcct ttggagatta aggcccctca gagatcaaca gaccaacatt tttctcttcc 1680  
tcaagcaaca ctcctagggc ctggcttctg tctgatcaag gcaccacaca acccagaaag 1740  
gagctgatgg ggcagaacga actttaagta tgagaaaagt tcagcccaag taaaataaaa 1800  
actcaatcac attcaattcc agagtagttt caagtttcac atcgtaacca ttttcgccc  1859  


<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: Synthetic 6x
      His tag"

<400> 5
His His His His His His                                          
  1               5    


<210> 6
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of artificial sequence: Synthetic
      oligonucleotide"

<220> 
<221> modified_base
<222> (3)..(21)
<223> a, c, g, t, unkown or other

<400> 6
aannnnnnnn nnnnnnnnnn ntt                                         23    


