                         SEQUENCE LISTING

<110>  Thymon, L.L.C.
       Goldstein, Gideon
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT AND PROPHYLAXIS OF 
       HYPERTENSION

<130>  GGP10APCT

<150>  US 60/955,695
<151>  2007-08-14

<160>  31    

<170>  PatentIn version 3.4

<210>  1
<211>  8
<212>  PRT
<213>  angiotensin II

<400>  1

Asp Arg Val Tyr Ile His Pro Phe 
1               5               


<210>  2
<211>  10
<212>  PRT
<213>  angiotensin I

<400>  2

Asp Arg Val Tyr Ile His Pro Phe His Leu 
1               5                   10  


<210>  3
<211>  15
<212>  PRT
<213>  tetanus toxin


<220>
<221>  MISC_FEATURE
<222>  (15)..(15)
<223>  can be Leu or absent

<400>  3

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Xaa 
1               5                   10                  15  


<210>  4
<211>  21
<212>  PRT
<213>  tetanus toxin

<400>  4

Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 
1               5                   10                  15      


Ala Ser His Leu Glu 
            20      


<210>  5
<211>  20
<212>  PRT
<213>  tetanus toxin

<400>  5

Ile Asp Lys Ile Ser Asp Val Ser Thr Ile Val Pro Tyr Ile Gly Pro 
1               5                   10                  15      


Ala Leu Asn Ile 
            20  


<210>  6
<211>  20
<212>  PRT
<213>  tetanus toxin

<400>  6

Asn Ser Val Asp Asp Ala Leu Ile Asn Ser Thr Lys Ile Tyr Ser Tyr 
1               5                   10                  15      


Phe Pro Ser Val 
            20  


<210>  7
<211>  17
<212>  PRT
<213>  tetanus toxin

<400>  7

Pro Gly Ile Asn Gly Lys Ala Ile His Leu Val Asn Asn Glu Ser Ser 
1               5                   10                  15      


Glu 
    


<210>  8
<211>  14
<212>  PRT
<213>  tetanus toxin

<400>  8

Glx Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu 
1               5                   10                  


<210>  9
<211>  21
<212>  PRT
<213>  Plasmodium falciparum

<400>  9

Asp Ile Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe 
1               5                   10                  15      


Asn Val Val Asn Ser 
            20      


<210>  10
<211>  16
<212>  PRT
<213>  Streptococcus

<400>  10

Gly Ala Val Asp Ser Ile Leu Gly Gly Val Ala Thr Tyr Gly Ala Ala 
1               5                   10                  15      


<210>  11
<211>  13
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  is D-Ala or L-Ala

<220>
<221>  MISC_FEATURE
<222>  (3)..(3)
<223>  is L-cyclohexylalanine or Phe or Tyr

<220>
<221>  MISC_FEATURE
<222>  (13)..(13)
<223>  is D-Ala or L-Ala

<400>  11

Xaa Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Ala Xaa 
1               5                   10              


<210>  12
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  12

Lys Lys Lys Lys 
1               


<210>  13
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  13

Lys Lys Lys Lys Lys Lys 
1               5       


<210>  14
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  14

Lys Glu Lys Glu 
1               


<210>  15
<211>  4
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  15

Glu Glu Glu Glu 
1               


<210>  16
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  16

Ser Lys Lys Lys Lys Ser 
1               5       


<210>  17
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  17

Ser Lys Lys Lys Lys Lys Lys Ser 
1               5               


<210>  18
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  18

Gly Lys Lys Lys Lys Gly 
1               5       


<210>  19
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  19

Gly Lys Lys Lys Lys Lys Lys Gly 
1               5               


<210>  20
<211>  6
<212>  PRT
<213>  Artificial

<220>
<223>  synthetic linker

<400>  20

Ser Lys Glu Lys Glu Ser 
1               5       


<210>  21
<211>  15
<212>  PRT
<213>  tetanus toxin

<400>  21

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 
1               5                   10                  15  


<210>  22
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  22

Cys Ser Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
1               5                   10                  15      


Glu Leu Ser Asp Arg Val Tyr Ile His Pro Phe 
            20                  25          


<210>  23
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  23

Cys Ser Lys Lys Lys Lys Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
1               5                   10                  15      


Ile Gly Ile Thr Glu Leu Ser Asp Arg Val Tyr Ile His Pro Phe 
            20                  25                  30      


<210>  24
<211>  32
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  24

Cys Ser Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
1               5                   10                  15      


Glu Leu Ser Lys Lys Lys Lys Ser Asp Arg Val Tyr Ile His Pro Phe 
            20                  25                  30          


<210>  25
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  25

Cys Ser Lys Lys Lys Lys Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe 
1               5                   10                  15      


Ile Gly Ile Thr Glu Leu Ser Lys Lys Lys Lys Ser Asp Arg Val Tyr 
            20                  25                  30          


Ile His Pro Phe 
        35      


<210>  26
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with NAc(dipalmitoyl-S-glyceryl)

<400>  26

Cys Ser Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
1               5                   10                  15      


Glu Leu Ser Asp Arg Val Tyr Ile His Pro Phe 
            20                  25          


<210>  27
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Lys is modified with one of these modified lipopeptides, 
       Pam2C-S-S or Pam2NAcC-S-S or Pam3C-S-S

<400>  27

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys 
1               5                   10                  15      


Ser Asp Arg Val Tyr Ile His Pro Phe 
            20                  25  


<210>  28
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with one of these modified lipopeptides, 
       dipalmitoyl-S-glyceryl or tripalmitoyl-S-glyceryl or  
       NAc(dipalmitoyl-S-glyceryl)

<400>  28

Cys Ser Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
1               5                   10                  15      


Glu Leu Ser Asp Arg Val Tyr Ile His Pro Phe 
            20                  25          


<210>  29
<211>  29
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with one of these modified lipopeptides, 
       dipalmitoyl-S-glyceryl or tripalmitoyl-S-glyceryl or  
       NAc(dipalmitoyl-S-glyceryl)

<400>  29

Cys Ser Ser Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr 
1               5                   10                  15      


Glu Leu Ser Asp Arg Val Tyr Ile His Pro Phe His Leu 
            20                  25                  


<210>  30
<211>  25
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (16)..(16)
<223>  Lys is modified with the modified lipopeptide, Pam2C-S-S

<400>  30

Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Lys 
1               5                   10                  15      


Ser Asp Arg Val Tyr Ile His Pro Phe 
            20                  25  


<210>  31
<211>  33
<212>  PRT
<213>  Artificial

<220>
<223>  chemically synthesized


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  cys is modified with the lipid, dipalmitoyl-S-glyceryl

<400>  31

Cys Ser Lys Lys Lys Lys Lys Lys Ser Gln Tyr Ile Lys Ala Asn Ser 
1               5                   10                  15      


Lys Phe Ile Gly Ile Thr Glu Leu Ser Asp Arg Val Tyr Ile His Pro 
            20                  25                  30          


Phe 
    


