                         SEQUENCE LISTING

<110>  University of Georgia Research Foundation, Inc.
 
<120>  Modified Peptides Having Toxin-Enhancing Effects

<130>  UGR-106XC1

<150>  US 60/964,249
<151>  2007-08-10

<150>  US 60/956,618
<151>  2007-08-17

<150>  US 61/084,951 
<151>  2008-07-30


<160>  30    

<170>  PatentIn version 3.3

<210>  1
<211>  1467
<212>  DNA
<213>  Manduca sexta


<220>
<221>  CDS
<222>  (1)..(1467)

<400>  1
atg gac ctc aag gga tat tgg ggg acg tac gct ata cat ata cgg gca       48
Met Asp Leu Lys Gly Tyr Trp Gly Thr Tyr Ala Ile His Ile Arg Ala         
1               5                   10                  15              

ttc gac cac ggc att ccg caa atg tcc atg aac gag aca tat gag ctg       96
Phe Asp His Gly Ile Pro Gln Met Ser Met Asn Glu Thr Tyr Glu Leu         
            20                  25                  30                  

att atc cat ccg ttc aac tac tac gcg cct gag ttc gtc ttc ccg acc      144
Ile Ile His Pro Phe Asn Tyr Tyr Ala Pro Glu Phe Val Phe Pro Thr         
        35                  40                  45                      

aac gat gcc gtc ata cga ctt gcg agg gaa cga gct gta atc aat gga      192
Asn Asp Ala Val Ile Arg Leu Ala Arg Glu Arg Ala Val Ile Asn Gly         
    50                  55                  60                          

gtt cta gcg aca gtg aac gga gag ttc ttg gag cgg ata tcg gcg act      240
Val Leu Ala Thr Val Asn Gly Glu Phe Leu Glu Arg Ile Ser Ala Thr         
65                  70                  75                  80          

gac ccg gac gga ctc cac gcg ggc gtc gtc acc ttc caa gtg gta ggc      288
Asp Pro Asp Gly Leu His Ala Gly Val Val Thr Phe Gln Val Val Gly         
                85                  90                  95              

gat gag gaa tca caa cgg tac ttt caa gta gtt aac gat ggc gcg aac      336
Asp Glu Glu Ser Gln Arg Tyr Phe Gln Val Val Asn Asp Gly Ala Asn         
            100                 105                 110                 

ctc ggc tcg ttg agg tta ctg caa gcc gtt cca gag gag atc agg gag      384
Leu Gly Ser Leu Arg Leu Leu Gln Ala Val Pro Glu Glu Ile Arg Glu         
        115                 120                 125                     

ttc cgg ata acg att cgc gct aca gac cag gga acg gac cca gga ccg      432
Phe Arg Ile Thr Ile Arg Ala Thr Asp Gln Gly Thr Asp Pro Gly Pro         
    130                 135                 140                         

ctg tcc acg gac atg acg ttc aga gtt gtt ttt gtg ccc acg caa gga      480
Leu Ser Thr Asp Met Thr Phe Arg Val Val Phe Val Pro Thr Gln Gly         
145                 150                 155                 160         

gaa cct aga ttc gcg tcc tca gaa cat gct gtc gct ttc ata gaa aag      528
Glu Pro Arg Phe Ala Ser Ser Glu His Ala Val Ala Phe Ile Glu Lys         
                165                 170                 175             

agt gcc ggc atg gaa gag tct cac caa ctt cct cta gca caa gac atc      576
Ser Ala Gly Met Glu Glu Ser His Gln Leu Pro Leu Ala Gln Asp Ile         
            180                 185                 190                 

aag aac cat ctc tgt gaa gac gac tgt cac agc att tac tat cgt att      624
Lys Asn His Leu Cys Glu Asp Asp Cys His Ser Ile Tyr Tyr Arg Ile         
        195                 200                 205                     

atc gat ggc aac agc gag ggt cat ttc ggc ctg gat cct gtt cgc aac      672
Ile Asp Gly Asn Ser Glu Gly His Phe Gly Leu Asp Pro Val Arg Asn         
    210                 215                 220                         

agg ttg ttc ctg aag aaa gag ctg ata aga gaa caa agt gcc tcc cac      720
Arg Leu Phe Leu Lys Lys Glu Leu Ile Arg Glu Gln Ser Ala Ser His         
225                 230                 235                 240         

act ctg caa gtg gcg gct agt aac tcg ccc gat ggt ggc att cca ctt      768
Thr Leu Gln Val Ala Ala Ser Asn Ser Pro Asp Gly Gly Ile Pro Leu         
                245                 250                 255             

cct gct tcc atc ctt act gtc act gtt acc gtg agg gag gca gac cct      816
Pro Ala Ser Ile Leu Thr Val Thr Val Thr Val Arg Glu Ala Asp Pro         
            260                 265                 270                 

cgt cca gtg ttt atg agg gaa ttg tac acc gca ggg ata tcc aca gcg      864
Arg Pro Val Phe Met Arg Glu Leu Tyr Thr Ala Gly Ile Ser Thr Ala         
        275                 280                 285                     

gac tcc atc ggc aga gag ctg ctc aga tta cat gcg acc cag tct gaa      912
Asp Ser Ile Gly Arg Glu Leu Leu Arg Leu His Ala Thr Gln Ser Glu         
    290                 295                 300                         

ggc gcg gcc att act tat gct ata gac tac gat aca atg gta gtg gac      960
Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr Asp Thr Met Val Val Asp         
305                 310                 315                 320         

ccc agc ctg gag gca gtg aga cag tcg gct ttc gta ctg aac gct caa     1008
Pro Ser Leu Glu Ala Val Arg Gln Ser Ala Phe Val Leu Asn Ala Gln         
                325                 330                 335             

acc gga gtg ctg acg ctt aat atc cag ccc acg gcc acg atg cat gga     1056
Thr Gly Val Leu Thr Leu Asn Ile Gln Pro Thr Ala Thr Met His Gly         
            340                 345                 350                 

ctg ttc aaa ttc gaa gtc aca gct act gac acg gcc ggc gct cag gac     1104
Leu Phe Lys Phe Glu Val Thr Ala Thr Asp Thr Ala Gly Ala Gln Asp         
        355                 360                 365                     

cgc acc gac gtc acc gtg tac gtg gta tcc tcg cag aac cgc gtc tac     1152
Arg Thr Asp Val Thr Val Tyr Val Val Ser Ser Gln Asn Arg Val Tyr         
    370                 375                 380                         

ttc gtg ttc gtc aac acg ctg caa cag gtc gaa gac aac aga gac ttt     1200
Phe Val Phe Val Asn Thr Leu Gln Gln Val Glu Asp Asn Arg Asp Phe         
385                 390                 395                 400         

atc gcg gac acc ttc agc gct ggg ttc aac atg acc tgc aac atc gac     1248
Ile Ala Asp Thr Phe Ser Ala Gly Phe Asn Met Thr Cys Asn Ile Asp         
                405                 410                 415             

caa gtg gtg ccc gcc aac gac ccc gtc acc ggc gtg gcg ctg gag cac     1296
Gln Val Val Pro Ala Asn Asp Pro Val Thr Gly Val Ala Leu Glu His         
            420                 425                 430                 

agc acg cag atg cgc ggc cac ttc ata cgg gac aac gta ccc gta ctc     1344
Ser Thr Gln Met Arg Gly His Phe Ile Arg Asp Asn Val Pro Val Leu         
        435                 440                 445                     

gct gat gag ata gaa cag atc cgt agt gac cta gtc ctc ctg agc tcg     1392
Ala Asp Glu Ile Glu Gln Ile Arg Ser Asp Leu Val Leu Leu Ser Ser         
    450                 455                 460                         

ata caa aca acg ctg gcg gcg cga tcg ctg gtg ttg cag gac ttg ttg     1440
Ile Gln Thr Thr Leu Ala Ala Arg Ser Leu Val Leu Gln Asp Leu Leu         
465                 470                 475                 480         

acc aac tcc agc ccg gac tcg gcg cct                                 1467
Thr Asn Ser Ser Pro Asp Ser Ala Pro                                     
                485                                                     


<210>  2
<211>  489
<212>  PRT
<213>  Manduca sexta

<400>  2

Met Asp Leu Lys Gly Tyr Trp Gly Thr Tyr Ala Ile His Ile Arg Ala 
1               5                   10                  15      


Phe Asp His Gly Ile Pro Gln Met Ser Met Asn Glu Thr Tyr Glu Leu 
            20                  25                  30          


Ile Ile His Pro Phe Asn Tyr Tyr Ala Pro Glu Phe Val Phe Pro Thr 
        35                  40                  45              


Asn Asp Ala Val Ile Arg Leu Ala Arg Glu Arg Ala Val Ile Asn Gly 
    50                  55                  60                  


Val Leu Ala Thr Val Asn Gly Glu Phe Leu Glu Arg Ile Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Asp Gly Leu His Ala Gly Val Val Thr Phe Gln Val Val Gly 
                85                  90                  95      


Asp Glu Glu Ser Gln Arg Tyr Phe Gln Val Val Asn Asp Gly Ala Asn 
            100                 105                 110         


Leu Gly Ser Leu Arg Leu Leu Gln Ala Val Pro Glu Glu Ile Arg Glu 
        115                 120                 125             


Phe Arg Ile Thr Ile Arg Ala Thr Asp Gln Gly Thr Asp Pro Gly Pro 
    130                 135                 140                 


Leu Ser Thr Asp Met Thr Phe Arg Val Val Phe Val Pro Thr Gln Gly 
145                 150                 155                 160 


Glu Pro Arg Phe Ala Ser Ser Glu His Ala Val Ala Phe Ile Glu Lys 
                165                 170                 175     


Ser Ala Gly Met Glu Glu Ser His Gln Leu Pro Leu Ala Gln Asp Ile 
            180                 185                 190         


Lys Asn His Leu Cys Glu Asp Asp Cys His Ser Ile Tyr Tyr Arg Ile 
        195                 200                 205             


Ile Asp Gly Asn Ser Glu Gly His Phe Gly Leu Asp Pro Val Arg Asn 
    210                 215                 220                 


Arg Leu Phe Leu Lys Lys Glu Leu Ile Arg Glu Gln Ser Ala Ser His 
225                 230                 235                 240 


Thr Leu Gln Val Ala Ala Ser Asn Ser Pro Asp Gly Gly Ile Pro Leu 
                245                 250                 255     


Pro Ala Ser Ile Leu Thr Val Thr Val Thr Val Arg Glu Ala Asp Pro 
            260                 265                 270         


Arg Pro Val Phe Met Arg Glu Leu Tyr Thr Ala Gly Ile Ser Thr Ala 
        275                 280                 285             


Asp Ser Ile Gly Arg Glu Leu Leu Arg Leu His Ala Thr Gln Ser Glu 
    290                 295                 300                 


Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr Asp Thr Met Val Val Asp 
305                 310                 315                 320 


Pro Ser Leu Glu Ala Val Arg Gln Ser Ala Phe Val Leu Asn Ala Gln 
                325                 330                 335     


Thr Gly Val Leu Thr Leu Asn Ile Gln Pro Thr Ala Thr Met His Gly 
            340                 345                 350         


Leu Phe Lys Phe Glu Val Thr Ala Thr Asp Thr Ala Gly Ala Gln Asp 
        355                 360                 365             


Arg Thr Asp Val Thr Val Tyr Val Val Ser Ser Gln Asn Arg Val Tyr 
    370                 375                 380                 


Phe Val Phe Val Asn Thr Leu Gln Gln Val Glu Asp Asn Arg Asp Phe 
385                 390                 395                 400 


Ile Ala Asp Thr Phe Ser Ala Gly Phe Asn Met Thr Cys Asn Ile Asp 
                405                 410                 415     


Gln Val Val Pro Ala Asn Asp Pro Val Thr Gly Val Ala Leu Glu His 
            420                 425                 430         


Ser Thr Gln Met Arg Gly His Phe Ile Arg Asp Asn Val Pro Val Leu 
        435                 440                 445             


Ala Asp Glu Ile Glu Gln Ile Arg Ser Asp Leu Val Leu Leu Ser Ser 
    450                 455                 460                 


Ile Gln Thr Thr Leu Ala Ala Arg Ser Leu Val Leu Gln Asp Leu Leu 
465                 470                 475                 480 


Thr Asn Ser Ser Pro Asp Ser Ala Pro 
                485                 


<210>  3
<211>  1467
<212>  DNA
<213>  Manduca sexta

<400>  3
atggacctca agggatattg ggggacgtac gctatacata tacgggcatt cgaccacggc     60

attccgcaaa tgtccatgaa cgagacatat gagctgatta tccatccgtt caactactac    120

gcgcctgagt tcgtcttccc gaccaacgat gccgtcatac gacttgcgag ggaacgagct    180

gtaatcaatg gagttctagc gacagtgaac ggagagttct tggagcggat atcggcgact    240

gacccggacg gactccacgc gggcgtcgtc accttccaag tggtaggcga tgaggaatca    300

caacggtact ttcaagtagt taacgatggc gcgaacctcg gctcgttgag gttactgcaa    360

gccgttccag aggagatcag ggagttccgg ataacgattc gcgctacaga ccagggaacg    420

gacccaggac cgctgtccac ggacatgacg ttcagagttg tttttgtgcc cacgcaagga    480

gaacctagat tcgcgtcctc agaacatgct gtcgctttca tagaaaagag tgccggcatg    540

gaagagtctc accaacttcc tctagcacaa gacatcaaga accatctctg tgaagacgac    600

tgtcacagca tttactatcg tattatcgat ggcaacagcg agggtcattt cggcctggat    660

cctgttcgca acaggttgtt cctgaagaaa gagctgataa gagaacaaag tgcctcccac    720

actctgcaag tggcggctag taactcgccc gatggtggca ttccacttcc tgcttccatc    780

cttactgtca ctgttaccgt gagggaggca gaccctcgtc cagtgtttat gagggaattg    840

tacaccgcag ggatatccac agcggactcc atcggcagag agctgctcag attacatgcg    900

acccagtctg aaggcgcggc cattacttat gctatagact acgatacaat ggtagtggac    960

cccagcctgg aggcagtgag acagtcggct ttcgtactga acgctcaaac cggagtgctg   1020

acgcttaata tccagcccac ggccacgatg catggactgt tcaaattcga agtcacagct   1080

actgacacgg ccggcgctca ggaccgcacc gacgtcaccg tgtacgtggt atcctcgcag   1140

aaccgcgtct acttcgtgtt cgtcaacacg ctgcaacagg tcgaagacaa cagagacttt   1200

atcgcggaca ccttcagcgc tgggttcaac atgacctgca acatcgacca agtggtgccc   1260

gccaacgacc ccgtcaccgg cgtggcgctg gagcacagca cgcagatgcg cggccacttc   1320

atacgggaca acgtacccgt actcgctgat gagatagaac agatccgtag tgacctagtc   1380

ctcctgagct cgatacaaac aacgctggcg gcgcgatcgc tggtgttgca ggacttgttg   1440

accaactcca gcccggactc ggcgcct                                       1467


<210>  4
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB2


<220>
<221>  CDS
<222>  (1)..(336)

<400>  4
atg ggg ata tcc aca gcg gac tcc atc ggc aga gag ctg ctc aga tta       48
Met Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu Leu Leu Arg Leu         
1               5                   10                  15              

cat gcg acc cag tct gaa ggc gcg gcc att act tat gct ata gac tac       96
His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr         
            20                  25                  30                  

gat aca atg gta gtg gac ccc agc ctg gag gca gtg aga cag tcg gct      144
Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Arg Gln Ser Ala         
        35                  40                  45                      

ttc gta ctg aac gct caa acc gga gtg ctg acg ctt aat atc cag ccc      192
Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn Ile Gln Pro         
    50                  55                  60                          

acg gcc acg atg cat gga ctg ttc aaa ttc gaa gtc aca gct act gac      240
Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val Thr Ala Thr Asp         
65                  70                  75                  80          

acg gcc ggc gct cag gac cgc acc gac gtc acc gtg tac gtg gta tcc      288
Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr Val Val Ser         
                85                  90                  95              

tcg cag aac cgc gtc tac ttc gtg ctc gag cac cac cac cac cac cac      336
Ser Gln Asn Arg Val Tyr Phe Val Leu Glu His His His His His His         
            100                 105                 110                 

tga                                                                  339


<210>  5
<211>  112
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BtB2

<400>  5

Met Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu Leu Leu Arg Leu 
1               5                   10                  15      


His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr 
            20                  25                  30          


Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Arg Gln Ser Ala 
        35                  40                  45              


Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn Ile Gln Pro 
    50                  55                  60                  


Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val Thr Ala Thr Asp 
65                  70                  75                  80  


Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr Val Val Ser 
                85                  90                  95      


Ser Gln Asn Arg Val Tyr Phe Val Leu Glu His His His His His His 
            100                 105                 110         


<210>  6
<211>  339
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB2

<400>  6
atggggatat ccacagcgga ctccatcggc agagagctgc tcagattaca tgcgacccag     60

tctgaaggcg cggccattac ttatgctata gactacgata caatggtagt ggaccccagc    120

ctggaggcag tgagacagtc ggctttcgta ctgaacgctc aaaccggagt gctgacgctt    180

aatatccagc ccacggccac gatgcatgga ctgttcaaat tcgaagtcac agctactgac    240

acggccggcg ctcaggaccg caccgacgtc accgtgtacg tggtatcctc gcagaaccgc    300

gtctacttcg tgctcgagca ccaccaccac caccactga                           339


<210>  7
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB3 (protease stabilized)


<220>
<221>  CDS
<222>  (1)..(333)

<400>  7
atg ggg ata tcc aca gcg gac tcc atc ggc agt gag ctg ctc agt tta       48
Met Gly Ile Ser Thr Ala Asp Ser Ile Gly Ser Glu Leu Leu Ser Leu         
1               5                   10                  15              

cat gcg acc cag tct gaa ggc gcg gcc att act tat gct ata gac tac       96
His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr         
            20                  25                  30                  

gat aca atg gta gtg gac ccc agc ctg gag gca gtg agt cag tcg gct      144
Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Ser Gln Ser Ala         
        35                  40                  45                      

ctc gta ctg aac gct caa acc gga gtg ctg acg ctt aat atc cag ccc      192
Leu Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn Ile Gln Pro         
    50                  55                  60                          

acg gcc acg atg cat gga ctg atc aat atc gaa gtc aca gct act gac      240
Thr Ala Thr Met His Gly Leu Ile Asn Ile Glu Val Thr Ala Thr Asp         
65                  70                  75                  80          

acg gcc ggc gct cag gac cgc acc gac gtc acc gtg tac gtg gta tcc      288
Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr Val Val Ser         
                85                  90                  95              

tcg cag aac cgc gtc tac ttc gtg ctc gag cac cac cac cac cac tga      336
Ser Gln Asn Arg Val Tyr Phe Val Leu Glu His His His His His             
            100                 105                 110                 


<210>  8
<211>  111
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BtB3 (protease stabilized)

<400>  8

Met Gly Ile Ser Thr Ala Asp Ser Ile Gly Ser Glu Leu Leu Ser Leu 
1               5                   10                  15      


His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr 
            20                  25                  30          


Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Ser Gln Ser Ala 
        35                  40                  45              


Leu Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn Ile Gln Pro 
    50                  55                  60                  


Thr Ala Thr Met His Gly Leu Ile Asn Ile Glu Val Thr Ala Thr Asp 
65                  70                  75                  80  


Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr Val Val Ser 
                85                  90                  95      


Ser Gln Asn Arg Val Tyr Phe Val Leu Glu His His His His His 
            100                 105                 110     


<210>  9
<211>  336
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB3 (protease stabilized)

<400>  9
atggggatat ccacagcgga ctccatcggc agtgagctgc tcagtttaca tgcgacccag     60

tctgaaggcg cggccattac ttatgctata gactacgata caatggtagt ggaccccagc    120

ctggaggcag tgagtcagtc ggctctcgta ctgaacgctc aaaccggagt gctgacgctt    180

aatatccagc ccacggccac gatgcatgga ctgatcaata tcgaagtcac agctactgac    240

acggccggcg ctcaggaccg caccgacgtc accgtgtacg tggtatcctc gcagaaccgc    300

gtctacttcg tgctcgagca ccaccaccac cactga                              336


<210>  10
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB4


<220>
<221>  CDS
<222>  (1)..(957)

<400>  10
atg cac ttg gag cgg ata tcg gcg act gac ccg gac gga ctc cac gcg       48
Met His Leu Glu Arg Ile Ser Ala Thr Asp Pro Asp Gly Leu His Ala         
1               5                   10                  15              

ggc gtc gtc acc ttc caa gtg gta ggc gat gag gaa tca caa cgg tac       96
Gly Val Val Thr Phe Gln Val Val Gly Asp Glu Glu Ser Gln Arg Tyr         
            20                  25                  30                  

ttt caa gta gtt aac gat ggc gcg aac ctc ggc tcg ttg agg tta ctg      144
Phe Gln Val Val Asn Asp Gly Ala Asn Leu Gly Ser Leu Arg Leu Leu         
        35                  40                  45                      

caa gcc gtt cca gag gag atc agg gag ttc cgg ata acg att cgc gct      192
Gln Ala Val Pro Glu Glu Ile Arg Glu Phe Arg Ile Thr Ile Arg Ala         
    50                  55                  60                          

aca gac cag gga acg gac cca gga ccg ctg tcc acg gac atg acg ttc      240
Thr Asp Gln Gly Thr Asp Pro Gly Pro Leu Ser Thr Asp Met Thr Phe         
65                  70                  75                  80          

aga gtt gtt ttt gtg ccc acg caa gga gaa cct aga ttc gcg tcc tca      288
Arg Val Val Phe Val Pro Thr Gln Gly Glu Pro Arg Phe Ala Ser Ser         
                85                  90                  95              

gaa cat gct gtc gct ttc ata gaa aag agt gcc ggc atg gaa gag tct      336
Glu His Ala Val Ala Phe Ile Glu Lys Ser Ala Gly Met Glu Glu Ser         
            100                 105                 110                 

cac caa ctt cct cta gca caa gac atc aag aac cat ctc tgt gaa gac      384
His Gln Leu Pro Leu Ala Gln Asp Ile Lys Asn His Leu Cys Glu Asp         
        115                 120                 125                     

gac tgt cac agc att tac tat cgt att atc gat ggc aac agc gag ggt      432
Asp Cys His Ser Ile Tyr Tyr Arg Ile Ile Asp Gly Asn Ser Glu Gly         
    130                 135                 140                         

cat ttc ggc ctg gat cct gtt cgc aac agg ttg ttc ctg aag aaa gag      480
His Phe Gly Leu Asp Pro Val Arg Asn Arg Leu Phe Leu Lys Lys Glu         
145                 150                 155                 160         

ctg ata aga gaa caa agt gcc tcc cac act ctg caa gtg gcg gct agt      528
Leu Ile Arg Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala Ser         
                165                 170                 175             

aac tcg ccc gat ggt ggc att cca ctt cct gct tcc atc ctt act gtc      576
Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr Val         
            180                 185                 190                 

act gtt acc gtg agg gag gca gac cct cgt cca gtg ttt atg agg gaa      624
Thr Val Thr Val Arg Glu Ala Asp Pro Arg Pro Val Phe Met Arg Glu         
        195                 200                 205                     

ttg tac acc gca ggg ata tcc aca gcg gac tcc atc ggc aga gag ctg      672
Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu Leu         
    210                 215                 220                         

ctc aga tta cat gcg acc cag tct gaa ggc gcg gcc att act tat gct      720
Leu Arg Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala         
225                 230                 235                 240         

ata gac tac gat aca atg gta gtg gac ccc agc ctg gag gca gtg aga      768
Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Arg         
                245                 250                 255             

cag tcg gct ttc gta ctg aac gct caa acc gga gtg ctg acg ctt aat      816
Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn         
            260                 265                 270                 

atc cag ccc acg gcc acg atg cat gga ctg ttc aaa ttc gaa gtc aca      864
Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val Thr         
        275                 280                 285                     

gct act gac acg gcc ggc gct cag gac cgc acc gac gtc acc gtg tac      912
Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr         
    290                 295                 300                         

gtg gta tcc tcg cag aac cgc ctc gag cac cac cac cac cac cac tga      960
Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His             
305                 310                 315                             


<210>  11
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BtB4

<400>  11

Met His Leu Glu Arg Ile Ser Ala Thr Asp Pro Asp Gly Leu His Ala 
1               5                   10                  15      


Gly Val Val Thr Phe Gln Val Val Gly Asp Glu Glu Ser Gln Arg Tyr 
            20                  25                  30          


Phe Gln Val Val Asn Asp Gly Ala Asn Leu Gly Ser Leu Arg Leu Leu 
        35                  40                  45              


Gln Ala Val Pro Glu Glu Ile Arg Glu Phe Arg Ile Thr Ile Arg Ala 
    50                  55                  60                  


Thr Asp Gln Gly Thr Asp Pro Gly Pro Leu Ser Thr Asp Met Thr Phe 
65                  70                  75                  80  


Arg Val Val Phe Val Pro Thr Gln Gly Glu Pro Arg Phe Ala Ser Ser 
                85                  90                  95      


Glu His Ala Val Ala Phe Ile Glu Lys Ser Ala Gly Met Glu Glu Ser 
            100                 105                 110         


His Gln Leu Pro Leu Ala Gln Asp Ile Lys Asn His Leu Cys Glu Asp 
        115                 120                 125             


Asp Cys His Ser Ile Tyr Tyr Arg Ile Ile Asp Gly Asn Ser Glu Gly 
    130                 135                 140                 


His Phe Gly Leu Asp Pro Val Arg Asn Arg Leu Phe Leu Lys Lys Glu 
145                 150                 155                 160 


Leu Ile Arg Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala Ser 
                165                 170                 175     


Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr Val 
            180                 185                 190         


Thr Val Thr Val Arg Glu Ala Asp Pro Arg Pro Val Phe Met Arg Glu 
        195                 200                 205             


Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu Leu 
    210                 215                 220                 


Leu Arg Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala 
225                 230                 235                 240 


Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Arg 
                245                 250                 255     


Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn 
            260                 265                 270         


Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val Thr 
        275                 280                 285             


Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr 
    290                 295                 300                 


Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His 
305                 310                 315                 


<210>  12
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB4

<400>  12
atgcacttgg agcggatatc ggcgactgac ccggacggac tccacgcggg cgtcgtcacc     60

ttccaagtgg taggcgatga ggaatcacaa cggtactttc aagtagttaa cgatggcgcg    120

aacctcggct cgttgaggtt actgcaagcc gttccagagg agatcaggga gttccggata    180

acgattcgcg ctacagacca gggaacggac ccaggaccgc tgtccacgga catgacgttc    240

agagttgttt ttgtgcccac gcaaggagaa cctagattcg cgtcctcaga acatgctgtc    300

gctttcatag aaaagagtgc cggcatggaa gagtctcacc aacttcctct agcacaagac    360

atcaagaacc atctctgtga agacgactgt cacagcattt actatcgtat tatcgatggc    420

aacagcgagg gtcatttcgg cctggatcct gttcgcaaca ggttgttcct gaagaaagag    480

ctgataagag aacaaagtgc ctcccacact ctgcaagtgg cggctagtaa ctcgcccgat    540

ggtggcattc cacttcctgc ttccatcctt actgtcactg ttaccgtgag ggaggcagac    600

cctcgtccag tgtttatgag ggaattgtac accgcaggga tatccacagc ggactccatc    660

ggcagagagc tgctcagatt acatgcgacc cagtctgaag gcgcggccat tacttatgct    720

atagactacg atacaatggt agtggacccc agcctggagg cagtgagaca gtcggctttc    780

gtactgaacg ctcaaaccgg agtgctgacg cttaatatcc agcccacggc cacgatgcat    840

ggactgttca aattcgaagt cacagctact gacacggccg gcgctcagga ccgcaccgac    900

gtcaccgtgt acgtggtatc ctcgcagaac cgcctcgagc accaccacca ccaccactga    960


<210>  13
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB5 (protease stabilized)


<220>
<221>  CDS
<222>  (1)..(957)

<400>  13
atg cac ctg gaa tgt atc tct gca acc gac ccg gat ggc ctg cat gct       48
Met His Leu Glu Cys Ile Ser Ala Thr Asp Pro Asp Gly Leu His Ala         
1               5                   10                  15              

ggt gta gta act ttc caa gtg gtt ggt gac gaa gaa agc cag gct tat       96
Gly Val Val Thr Phe Gln Val Val Gly Asp Glu Glu Ser Gln Ala Tyr         
            20                  25                  30                  

ttc cag gtt gtt aac gac ggt gca aac ctg ggc tcc ctt tcc ctg ctg      144
Phe Gln Val Val Asn Asp Gly Ala Asn Leu Gly Ser Leu Ser Leu Leu         
        35                  40                  45                      

cag gcc gtg cca gaa gaa atc gca gag ttc agc att acc atc tgc gct      192
Gln Ala Val Pro Glu Glu Ile Ala Glu Phe Ser Ile Thr Ile Cys Ala         
    50                  55                  60                          

acc gac caa ggt acc gac ccg ggc ccg ctg agc acc gac atg acc ttc      240
Thr Asp Gln Gly Thr Asp Pro Gly Pro Leu Ser Thr Asp Met Thr Phe         
65                  70                  75                  80          

gct gtt gta ttc gtt cct act cag ggt gaa cca gct ttc gct tcc tct      288
Ala Val Val Phe Val Pro Thr Gln Gly Glu Pro Ala Phe Ala Ser Ser         
                85                  90                  95              

gag cac gca gta gca ttc atc gaa gcc tcc gcg ggt atg gaa gaa tct      336
Glu His Ala Val Ala Phe Ile Glu Ala Ser Ala Gly Met Glu Glu Ser         
            100                 105                 110                 

cat cag ctc cca ctg gct caa gat atc gcg aac cat ctg tgt gaa gac      384
His Gln Leu Pro Leu Ala Gln Asp Ile Ala Asn His Leu Cys Glu Asp         
        115                 120                 125                     

gac tgc cac tct atc tac tac gct atc atc gac ggt aac agc gaa ggt      432
Asp Cys His Ser Ile Tyr Tyr Ala Ile Ile Asp Gly Asn Ser Glu Gly         
    130                 135                 140                         

cac ttc ggt ctg gac ccg gta gct aac gcg ctg ttc ctg tct gct gaa      480
His Phe Gly Leu Asp Pro Val Ala Asn Ala Leu Phe Leu Ser Ala Glu         
145                 150                 155                 160         

ctg atc gcg gaa cag agc gct tct cac act tta caa gtt gct gcg tcc      528
Leu Ile Ala Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala Ser         
                165                 170                 175             

aac agc ccg gac ggt ggc atc cct ctg cct gca tct atc ctt acc gtt      576
Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr Val         
            180                 185                 190                 

acc gta acc gtc gct gaa gca gat cca gca ccg gta ttc atg gct gag      624
Thr Val Thr Val Ala Glu Ala Asp Pro Ala Pro Val Phe Met Ala Glu         
        195                 200                 205                     

ctg tac acg gct ggc atc agc act gcc gac tcc att ggc tgc gaa ctt      672
Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Cys Glu Leu         
    210                 215                 220                         

ctg gct ctg cat gcg act cag tca gaa ggc gcg gcc atc acc tat gct      720
Leu Ala Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala         
225                 230                 235                 240         

atc gac tat gat acc atg gta gtt gat ccg tct ctg gaa gca gtt tgc      768
Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Cys         
                245                 250                 255             

cag tct gct ttc gtt ctg aac gca cag act ggt gtt ctg act ctg aac      816
Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn         
            260                 265                 270                 

atc cag ccg act gca acg atg cat ggt ctg ttc aac ttc gaa gtt act      864
Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Asn Phe Glu Val Thr         
        275                 280                 285                     

gcg acc gac act gcg ggc gct cag gac cgt act gac gtt acc gtc tac      912
Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr         
    290                 295                 300                         

gta gtg tct tct cag aac cgt ctg gaa cac cac cac cac cac cac taa      960
Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His             
305                 310                 315                             


<210>  14
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BtB5 (protease stabilized)

<400>  14

Met His Leu Glu Cys Ile Ser Ala Thr Asp Pro Asp Gly Leu His Ala 
1               5                   10                  15      


Gly Val Val Thr Phe Gln Val Val Gly Asp Glu Glu Ser Gln Ala Tyr 
            20                  25                  30          


Phe Gln Val Val Asn Asp Gly Ala Asn Leu Gly Ser Leu Ser Leu Leu 
        35                  40                  45              


Gln Ala Val Pro Glu Glu Ile Ala Glu Phe Ser Ile Thr Ile Cys Ala 
    50                  55                  60                  


Thr Asp Gln Gly Thr Asp Pro Gly Pro Leu Ser Thr Asp Met Thr Phe 
65                  70                  75                  80  


Ala Val Val Phe Val Pro Thr Gln Gly Glu Pro Ala Phe Ala Ser Ser 
                85                  90                  95      


Glu His Ala Val Ala Phe Ile Glu Ala Ser Ala Gly Met Glu Glu Ser 
            100                 105                 110         


His Gln Leu Pro Leu Ala Gln Asp Ile Ala Asn His Leu Cys Glu Asp 
        115                 120                 125             


Asp Cys His Ser Ile Tyr Tyr Ala Ile Ile Asp Gly Asn Ser Glu Gly 
    130                 135                 140                 


His Phe Gly Leu Asp Pro Val Ala Asn Ala Leu Phe Leu Ser Ala Glu 
145                 150                 155                 160 


Leu Ile Ala Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala Ser 
                165                 170                 175     


Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr Val 
            180                 185                 190         


Thr Val Thr Val Ala Glu Ala Asp Pro Ala Pro Val Phe Met Ala Glu 
        195                 200                 205             


Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Cys Glu Leu 
    210                 215                 220                 


Leu Ala Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala 
225                 230                 235                 240 


Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Cys 
                245                 250                 255     


Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn 
            260                 265                 270         


Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Asn Phe Glu Val Thr 
        275                 280                 285             


Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr 
    290                 295                 300                 


Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His 
305                 310                 315                 


<210>  15
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB5 (protease stabilized)

<400>  15
atgcacctgg aatgtatctc tgcaaccgac ccggatggcc tgcatgctgg tgtagtaact     60

ttccaagtgg ttggtgacga agaaagccag gcttatttcc aggttgttaa cgacggtgca    120

aacctgggct ccctttccct gctgcaggcc gtgccagaag aaatcgcaga gttcagcatt    180

accatctgcg ctaccgacca aggtaccgac ccgggcccgc tgagcaccga catgaccttc    240

gctgttgtat tcgttcctac tcagggtgaa ccagctttcg cttcctctga gcacgcagta    300

gcattcatcg aagcctccgc gggtatggaa gaatctcatc agctcccact ggctcaagat    360

atcgcgaacc atctgtgtga agacgactgc cactctatct actacgctat catcgacggt    420

aacagcgaag gtcacttcgg tctggacccg gtagctaacg cgctgttcct gtctgctgaa    480

ctgatcgcgg aacagagcgc ttctcacact ttacaagttg ctgcgtccaa cagcccggac    540

ggtggcatcc ctctgcctgc atctatcctt accgttaccg taaccgtcgc tgaagcagat    600

ccagcaccgg tattcatggc tgagctgtac acggctggca tcagcactgc cgactccatt    660

ggctgcgaac ttctggctct gcatgcgact cagtcagaag gcgcggccat cacctatgct    720

atcgactatg ataccatggt agttgatccg tctctggaag cagtttgcca gtctgctttc    780

gttctgaacg cacagactgg tgttctgact ctgaacatcc agccgactgc aacgatgcat    840

ggtctgttca acttcgaagt tactgcgacc gacactgcgg gcgctcagga ccgtactgac    900

gttaccgtct acgtagtgtc ttctcagaac cgtctggaac accaccacca ccaccactaa    960


<210>  16
<211>  1824
<212>  DNA
<213>  Manduca sexta


<220>
<221>  CDS
<222>  (1)..(1821)

<400>  16
gaa ttc gaa gga aat atc aca atc cac atc acc gac acg aac aac aag       48
Glu Phe Glu Gly Asn Ile Thr Ile His Ile Thr Asp Thr Asn Asn Lys         
1               5                   10                  15              

gtc ccg cag gcg gaa acg act aag ttc gat acc gtc gtg tat att tac       96
Val Pro Gln Ala Glu Thr Thr Lys Phe Asp Thr Val Val Tyr Ile Tyr         
            20                  25                  30                  

gag aac gca acc cac ttg gac gag gtg gtc act ctg ata gcc agt gat      144
Glu Asn Ala Thr His Leu Asp Glu Val Val Thr Leu Ile Ala Ser Asp         
        35                  40                  45                      

ctt gac aga gac gaa ata tac cac acg gtg agc tac gtc atc aat tac      192
Leu Asp Arg Asp Glu Ile Tyr His Thr Val Ser Tyr Val Ile Asn Tyr         
    50                  55                  60                          

gca gtg aac cct cga ctg atg aac ttc ttc tcc gtg aac cgg gag acc      240
Ala Val Asn Pro Arg Leu Met Asn Phe Phe Ser Val Asn Arg Glu Thr         
65                  70                  75                  80          

ggc ctg gtg tac gta gac tat gag acc cag ggg agt ggc gag gtg ctg      288
Gly Leu Val Tyr Val Asp Tyr Glu Thr Gln Gly Ser Gly Glu Val Leu         
                85                  90                  95              

gac cgt gat ggt gat gaa cca acg cac cgt atc ttc ttc aac ctc atc      336
Asp Arg Asp Gly Asp Glu Pro Thr His Arg Ile Phe Phe Asn Leu Ile         
            100                 105                 110                 

gac aac ttc atg ggg gaa gga gaa ggt aac aga aat cag aac gac aca      384
Asp Asn Phe Met Gly Glu Gly Glu Gly Asn Arg Asn Gln Asn Asp Thr         
        115                 120                 125                     

gaa gtt ctc gtt atc ttg ttg gat gtg aat gac aat gct cct gaa ttg      432
Glu Val Leu Val Ile Leu Leu Asp Val Asn Asp Asn Ala Pro Glu Leu         
    130                 135                 140                         

cca ccg ccg agc gaa ctc tct tgg act ata tct gag aac ctt aag cag      480
Pro Pro Pro Ser Glu Leu Ser Trp Thr Ile Ser Glu Asn Leu Lys Gln         
145                 150                 155                 160         

ggc gtc cgt ctt gaa ccg cat atc ttc gcc ccg gac cgc gac gag ccc      528
Gly Val Arg Leu Glu Pro His Ile Phe Ala Pro Asp Arg Asp Glu Pro         
                165                 170                 175             

gac acg gac aac tcc agg gtc ggt tac gag atc ctg aac ctc agc acg      576
Asp Thr Asp Asn Ser Arg Val Gly Tyr Glu Ile Leu Asn Leu Ser Thr         
            180                 185                 190                 

gag cgg gac atc gaa gtg ccg gag ctg ttt gta atg ata cag atc gcg      624
Glu Arg Asp Ile Glu Val Pro Glu Leu Phe Val Met Ile Gln Ile Ala         
        195                 200                 205                     

aac gtc acg gga gag ctg gag acc gcc atg gac ctc aag gga tat tgg      672
Asn Val Thr Gly Glu Leu Glu Thr Ala Met Asp Leu Lys Gly Tyr Trp         
    210                 215                 220                         

ggg acg tac gct ata cat ata cgg gca ttc gac cac ggc att ccg caa      720
Gly Thr Tyr Ala Ile His Ile Arg Ala Phe Asp His Gly Ile Pro Gln         
225                 230                 235                 240         

atg tcc atg aac gag aca tat gag ctg att atc cat ccg ttc aac tac      768
Met Ser Met Asn Glu Thr Tyr Glu Leu Ile Ile His Pro Phe Asn Tyr         
                245                 250                 255             

tac gcg cct gag ttc gtc ttc ccg acc aac gat gcc gtc ata cga ctt      816
Tyr Ala Pro Glu Phe Val Phe Pro Thr Asn Asp Ala Val Ile Arg Leu         
            260                 265                 270                 

gcg agg gaa cga gct gta atc aat gga gtt cta gcg aca gtg aac gga      864
Ala Arg Glu Arg Ala Val Ile Asn Gly Val Leu Ala Thr Val Asn Gly         
        275                 280                 285                     

gag ttc ttg gag cgg ata tcg gcg act gac ccg gac gga ctc cac gcg      912
Glu Phe Leu Glu Arg Ile Ser Ala Thr Asp Pro Asp Gly Leu His Ala         
    290                 295                 300                         

ggc gtc gtc acc ttc caa gtg gta ggc gat gag gaa tca caa cgg tac      960
Gly Val Val Thr Phe Gln Val Val Gly Asp Glu Glu Ser Gln Arg Tyr         
305                 310                 315                 320         

ttt caa gta gtt aac gat ggc gcg aac ctc ggc tcg ttg agg tta ctg     1008
Phe Gln Val Val Asn Asp Gly Ala Asn Leu Gly Ser Leu Arg Leu Leu         
                325                 330                 335             

caa gcc gtt cca gag gag atc agg gag ttc cgg ata acg att cgc gct     1056
Gln Ala Val Pro Glu Glu Ile Arg Glu Phe Arg Ile Thr Ile Arg Ala         
            340                 345                 350                 

aca gac cag gga acg gac cca gga ccg ctg tcc acg gac atg acg ttc     1104
Thr Asp Gln Gly Thr Asp Pro Gly Pro Leu Ser Thr Asp Met Thr Phe         
        355                 360                 365                     

aga gtt gtt ttt gtg ccc acg caa gga gaa cct aga ttc gcg tcc tca     1152
Arg Val Val Phe Val Pro Thr Gln Gly Glu Pro Arg Phe Ala Ser Ser         
    370                 375                 380                         

gaa cat gct gtc gct ttc ata gaa aag agt gcc ggc atg gaa gag tct     1200
Glu His Ala Val Ala Phe Ile Glu Lys Ser Ala Gly Met Glu Glu Ser         
385                 390                 395                 400         

cac caa ctt cct cta gca caa gac atc aag aac cat ctc tgt gaa gac     1248
His Gln Leu Pro Leu Ala Gln Asp Ile Lys Asn His Leu Cys Glu Asp         
                405                 410                 415             

gac tgt cac agc att tac tat cgt att atc gat ggc aac agc gag ggt     1296
Asp Cys His Ser Ile Tyr Tyr Arg Ile Ile Asp Gly Asn Ser Glu Gly         
            420                 425                 430                 

cat ttc ggc ctg gat cct gtt cgc aac agg ttg ttc ctg aag aaa gag     1344
His Phe Gly Leu Asp Pro Val Arg Asn Arg Leu Phe Leu Lys Lys Glu         
        435                 440                 445                     

ctg ata aga gaa caa agt gcc tcc cac act ctg caa gtg gcg gct agt     1392
Leu Ile Arg Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala Ser         
    450                 455                 460                         

aac tcg ccc gat ggt ggc att cca ctt cct gct tcc atc ctt act gtc     1440
Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr Val         
465                 470                 475                 480         

act gtt acc gtg agg gag gca gac cct cgt cca gtg ttt atg agg gaa     1488
Thr Val Thr Val Arg Glu Ala Asp Pro Arg Pro Val Phe Met Arg Glu         
                485                 490                 495             

ttg tac acc gca ggg ata tcc aca gcg gac tcc atc ggc aga gag ctg     1536
Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu Leu         
            500                 505                 510                 

ctc aga tta cat gcg acc cag tct gaa ggc gcg gcc att act tat gct     1584
Leu Arg Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala         
        515                 520                 525                     

ata gac tac gat aca atg gta gtg gac ccc agc ctg gag gca gtg aga     1632
Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Arg         
    530                 535                 540                         

cag tcg gct ttc gta ctg aac gct caa acc gga gtg ctg acg ctt aat     1680
Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn         
545                 550                 555                 560         

atc cag ccc acg gcc acg atg cat gga ctg ttc aaa ttc gaa gtc aca     1728
Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val Thr         
                565                 570                 575             

gct act gac acg gcc ggc gct cag gac cgc acc gac gtc acc gtg tac     1776
Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr         
            580                 585                 590                 

gtg gta tcc tcg cag aac cgc ctc gag cac cac cac cac cac cac tga     1824
Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His             
        595                 600                 605                     


<210>  17
<211>  607
<212>  PRT
<213>  Manduca sexta

<400>  17

Glu Phe Glu Gly Asn Ile Thr Ile His Ile Thr Asp Thr Asn Asn Lys 
1               5                   10                  15      


Val Pro Gln Ala Glu Thr Thr Lys Phe Asp Thr Val Val Tyr Ile Tyr 
            20                  25                  30          


Glu Asn Ala Thr His Leu Asp Glu Val Val Thr Leu Ile Ala Ser Asp 
        35                  40                  45              


Leu Asp Arg Asp Glu Ile Tyr His Thr Val Ser Tyr Val Ile Asn Tyr 
    50                  55                  60                  


Ala Val Asn Pro Arg Leu Met Asn Phe Phe Ser Val Asn Arg Glu Thr 
65                  70                  75                  80  


Gly Leu Val Tyr Val Asp Tyr Glu Thr Gln Gly Ser Gly Glu Val Leu 
                85                  90                  95      


Asp Arg Asp Gly Asp Glu Pro Thr His Arg Ile Phe Phe Asn Leu Ile 
            100                 105                 110         


Asp Asn Phe Met Gly Glu Gly Glu Gly Asn Arg Asn Gln Asn Asp Thr 
        115                 120                 125             


Glu Val Leu Val Ile Leu Leu Asp Val Asn Asp Asn Ala Pro Glu Leu 
    130                 135                 140                 


Pro Pro Pro Ser Glu Leu Ser Trp Thr Ile Ser Glu Asn Leu Lys Gln 
145                 150                 155                 160 


Gly Val Arg Leu Glu Pro His Ile Phe Ala Pro Asp Arg Asp Glu Pro 
                165                 170                 175     


Asp Thr Asp Asn Ser Arg Val Gly Tyr Glu Ile Leu Asn Leu Ser Thr 
            180                 185                 190         


Glu Arg Asp Ile Glu Val Pro Glu Leu Phe Val Met Ile Gln Ile Ala 
        195                 200                 205             


Asn Val Thr Gly Glu Leu Glu Thr Ala Met Asp Leu Lys Gly Tyr Trp 
    210                 215                 220                 


Gly Thr Tyr Ala Ile His Ile Arg Ala Phe Asp His Gly Ile Pro Gln 
225                 230                 235                 240 


Met Ser Met Asn Glu Thr Tyr Glu Leu Ile Ile His Pro Phe Asn Tyr 
                245                 250                 255     


Tyr Ala Pro Glu Phe Val Phe Pro Thr Asn Asp Ala Val Ile Arg Leu 
            260                 265                 270         


Ala Arg Glu Arg Ala Val Ile Asn Gly Val Leu Ala Thr Val Asn Gly 
        275                 280                 285             


Glu Phe Leu Glu Arg Ile Ser Ala Thr Asp Pro Asp Gly Leu His Ala 
    290                 295                 300                 


Gly Val Val Thr Phe Gln Val Val Gly Asp Glu Glu Ser Gln Arg Tyr 
305                 310                 315                 320 


Phe Gln Val Val Asn Asp Gly Ala Asn Leu Gly Ser Leu Arg Leu Leu 
                325                 330                 335     


Gln Ala Val Pro Glu Glu Ile Arg Glu Phe Arg Ile Thr Ile Arg Ala 
            340                 345                 350         


Thr Asp Gln Gly Thr Asp Pro Gly Pro Leu Ser Thr Asp Met Thr Phe 
        355                 360                 365             


Arg Val Val Phe Val Pro Thr Gln Gly Glu Pro Arg Phe Ala Ser Ser 
    370                 375                 380                 


Glu His Ala Val Ala Phe Ile Glu Lys Ser Ala Gly Met Glu Glu Ser 
385                 390                 395                 400 


His Gln Leu Pro Leu Ala Gln Asp Ile Lys Asn His Leu Cys Glu Asp 
                405                 410                 415     


Asp Cys His Ser Ile Tyr Tyr Arg Ile Ile Asp Gly Asn Ser Glu Gly 
            420                 425                 430         


His Phe Gly Leu Asp Pro Val Arg Asn Arg Leu Phe Leu Lys Lys Glu 
        435                 440                 445             


Leu Ile Arg Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala Ser 
    450                 455                 460                 


Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr Val 
465                 470                 475                 480 


Thr Val Thr Val Arg Glu Ala Asp Pro Arg Pro Val Phe Met Arg Glu 
                485                 490                 495     


Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu Leu 
            500                 505                 510         


Leu Arg Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr Ala 
        515                 520                 525             


Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val Arg 
    530                 535                 540                 


Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu Asn 
545                 550                 555                 560 


Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val Thr 
                565                 570                 575     


Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val Tyr 
            580                 585                 590         


Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His 
        595                 600                 605         


<210>  18
<211>  1824
<212>  DNA
<213>  Manduca sexta

<400>  18
gaattcgaag gaaatatcac aatccacatc accgacacga acaacaaggt cccgcaggcg     60

gaaacgacta agttcgatac cgtcgtgtat atttacgaga acgcaaccca cttggacgag    120

gtggtcactc tgatagccag tgatcttgac agagacgaaa tataccacac ggtgagctac    180

gtcatcaatt acgcagtgaa ccctcgactg atgaacttct tctccgtgaa ccgggagacc    240

ggcctggtgt acgtagacta tgagacccag gggagtggcg aggtgctgga ccgtgatggt    300

gatgaaccaa cgcaccgtat cttcttcaac ctcatcgaca acttcatggg ggaaggagaa    360

ggtaacagaa atcagaacga cacagaagtt ctcgttatct tgttggatgt gaatgacaat    420

gctcctgaat tgccaccgcc gagcgaactc tcttggacta tatctgagaa ccttaagcag    480

ggcgtccgtc ttgaaccgca tatcttcgcc ccggaccgcg acgagcccga cacggacaac    540

tccagggtcg gttacgagat cctgaacctc agcacggagc gggacatcga agtgccggag    600

ctgtttgtaa tgatacagat cgcgaacgtc acgggagagc tggagaccgc catggacctc    660

aagggatatt gggggacgta cgctatacat atacgggcat tcgaccacgg cattccgcaa    720

atgtccatga acgagacata tgagctgatt atccatccgt tcaactacta cgcgcctgag    780

ttcgtcttcc cgaccaacga tgccgtcata cgacttgcga gggaacgagc tgtaatcaat    840

ggagttctag cgacagtgaa cggagagttc ttggagcgga tatcggcgac tgacccggac    900

ggactccacg cgggcgtcgt caccttccaa gtggtaggcg atgaggaatc acaacggtac    960

tttcaagtag ttaacgatgg cgcgaacctc ggctcgttga ggttactgca agccgttcca   1020

gaggagatca gggagttccg gataacgatt cgcgctacag accagggaac ggacccagga   1080

ccgctgtcca cggacatgac gttcagagtt gtttttgtgc ccacgcaagg agaacctaga   1140

ttcgcgtcct cagaacatgc tgtcgctttc atagaaaaga gtgccggcat ggaagagtct   1200

caccaacttc ctctagcaca agacatcaag aaccatctct gtgaagacga ctgtcacagc   1260

atttactatc gtattatcga tggcaacagc gagggtcatt tcggcctgga tcctgttcgc   1320

aacaggttgt tcctgaagaa agagctgata agagaacaaa gtgcctccca cactctgcaa   1380

gtggcggcta gtaactcgcc cgatggtggc attccacttc ctgcttccat ccttactgtc   1440

actgttaccg tgagggaggc agaccctcgt ccagtgttta tgagggaatt gtacaccgca   1500

gggatatcca cagcggactc catcggcaga gagctgctca gattacatgc gacccagtct   1560

gaaggcgcgg ccattactta tgctatagac tacgatacaa tggtagtgga ccccagcctg   1620

gaggcagtga gacagtcggc tttcgtactg aacgctcaaa ccggagtgct gacgcttaat   1680

atccagccca cggccacgat gcatggactg ttcaaattcg aagtcacagc tactgacacg   1740

gccggcgctc aggaccgcac cgacgtcacc gtgtacgtgg tatcctcgca gaaccgcctc   1800

gagcaccacc accaccacca ctga                                          1824


<210>  19
<211>  1173
<212>  DNA
<213>  Manduca sexta


<220>
<221>  CDS
<222>  (1)..(1170)

<400>  19
atg gac ctc aag gga tat tgg ggg acg tac gct ata cat ata cgg gca       48
Met Asp Leu Lys Gly Tyr Trp Gly Thr Tyr Ala Ile His Ile Arg Ala         
1               5                   10                  15              

ttc gac cac ggc att ccg caa atg tcc atg aac gag aca tat gag ctg       96
Phe Asp His Gly Ile Pro Gln Met Ser Met Asn Glu Thr Tyr Glu Leu         
            20                  25                  30                  

att atc cat ccg ttc aac tac tac gcg cct gag ttc gtc ttc ccg acc      144
Ile Ile His Pro Phe Asn Tyr Tyr Ala Pro Glu Phe Val Phe Pro Thr         
        35                  40                  45                      

aac gat gcc gtc ata cga ctt gcg agg gaa cga gct gta atc aat gga      192
Asn Asp Ala Val Ile Arg Leu Ala Arg Glu Arg Ala Val Ile Asn Gly         
    50                  55                  60                          

gtt cta gcg aca gtg aac gga gag ttc ttg gag cgg ata tcg gcg act      240
Val Leu Ala Thr Val Asn Gly Glu Phe Leu Glu Arg Ile Ser Ala Thr         
65                  70                  75                  80          

gac ccg gac gga ctc cac gcg ggc gtc gtc acc ttc caa gtg gta ggc      288
Asp Pro Asp Gly Leu His Ala Gly Val Val Thr Phe Gln Val Val Gly         
                85                  90                  95              

gat gag gaa tca caa cgg tac ttt caa gta gtt aac gat ggc gcg aac      336
Asp Glu Glu Ser Gln Arg Tyr Phe Gln Val Val Asn Asp Gly Ala Asn         
            100                 105                 110                 

ctc ggc tcg ttg agg tta ctg caa gcc gtt cca gag gag atc agg gag      384
Leu Gly Ser Leu Arg Leu Leu Gln Ala Val Pro Glu Glu Ile Arg Glu         
        115                 120                 125                     

ttc cgg ata acg att cgc gct aca gac cag gga acg gac cca gga ccg      432
Phe Arg Ile Thr Ile Arg Ala Thr Asp Gln Gly Thr Asp Pro Gly Pro         
    130                 135                 140                         

ctg tcc acg gac atg acg ttc aga gtt gtt ttt gtg ccc acg caa gga      480
Leu Ser Thr Asp Met Thr Phe Arg Val Val Phe Val Pro Thr Gln Gly         
145                 150                 155                 160         

gaa cct aga ttc gcg tcc tca gaa cat gct gtc gct ttc ata gaa aag      528
Glu Pro Arg Phe Ala Ser Ser Glu His Ala Val Ala Phe Ile Glu Lys         
                165                 170                 175             

agt gcc ggc atg gaa gag tct cac caa ctt cct cta gca caa gac atc      576
Ser Ala Gly Met Glu Glu Ser His Gln Leu Pro Leu Ala Gln Asp Ile         
            180                 185                 190                 

aag aac cat ctc tgt gaa gac gac tgt cac agc att tac tat cgt att      624
Lys Asn His Leu Cys Glu Asp Asp Cys His Ser Ile Tyr Tyr Arg Ile         
        195                 200                 205                     

atc gat ggc aac agc gag ggt cat ttc ggc ctg gat cct gtt cgc aac      672
Ile Asp Gly Asn Ser Glu Gly His Phe Gly Leu Asp Pro Val Arg Asn         
    210                 215                 220                         

agg ttg ttc ctg aag aaa gag ctg ata aga gaa caa agt gcc tcc cac      720
Arg Leu Phe Leu Lys Lys Glu Leu Ile Arg Glu Gln Ser Ala Ser His         
225                 230                 235                 240         

act ctg caa gtg gcg gct agt aac tcg ccc gat ggt ggc att cca ctt      768
Thr Leu Gln Val Ala Ala Ser Asn Ser Pro Asp Gly Gly Ile Pro Leu         
                245                 250                 255             

cct gct tcc atc ctt act gtc act gtt acc gtg agg gag gca gac cct      816
Pro Ala Ser Ile Leu Thr Val Thr Val Thr Val Arg Glu Ala Asp Pro         
            260                 265                 270                 

cgt cca gtg ttt atg agg gaa ttg tac acc gca ggg ata tcc aca gcg      864
Arg Pro Val Phe Met Arg Glu Leu Tyr Thr Ala Gly Ile Ser Thr Ala         
        275                 280                 285                     

gac tcc atc ggc aga gag ctg ctc aga tta cat gcg acc cag tct gaa      912
Asp Ser Ile Gly Arg Glu Leu Leu Arg Leu His Ala Thr Gln Ser Glu         
    290                 295                 300                         

ggc gcg gcc att act tat gct ata gac tac gat aca atg gta gtg gac      960
Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr Asp Thr Met Val Val Asp         
305                 310                 315                 320         

ccc agc ctg gag gca gtg aga cag tcg gct ttc gta ctg aac gct caa     1008
Pro Ser Leu Glu Ala Val Arg Gln Ser Ala Phe Val Leu Asn Ala Gln         
                325                 330                 335             

acc gga gtg ctg acg ctt aat atc cag ccc acg gcc acg atg cat gga     1056
Thr Gly Val Leu Thr Leu Asn Ile Gln Pro Thr Ala Thr Met His Gly         
            340                 345                 350                 

ctg ttc aaa ttc gaa gtc aca gct act gac acg gcc ggc gct cag gac     1104
Leu Phe Lys Phe Glu Val Thr Ala Thr Asp Thr Ala Gly Ala Gln Asp         
        355                 360                 365                     

cgc acc gac gtc acc gtg tac gtg gta tcc tcg cag aac cgc ctc gag     1152
Arg Thr Asp Val Thr Val Tyr Val Val Ser Ser Gln Asn Arg Leu Glu         
    370                 375                 380                         

cac cac cac cac cac cac tga                                         1173
His His His His His His                                                 
385                 390                                                 


<210>  20
<211>  390
<212>  PRT
<213>  Manduca sexta

<400>  20

Met Asp Leu Lys Gly Tyr Trp Gly Thr Tyr Ala Ile His Ile Arg Ala 
1               5                   10                  15      


Phe Asp His Gly Ile Pro Gln Met Ser Met Asn Glu Thr Tyr Glu Leu 
            20                  25                  30          


Ile Ile His Pro Phe Asn Tyr Tyr Ala Pro Glu Phe Val Phe Pro Thr 
        35                  40                  45              


Asn Asp Ala Val Ile Arg Leu Ala Arg Glu Arg Ala Val Ile Asn Gly 
    50                  55                  60                  


Val Leu Ala Thr Val Asn Gly Glu Phe Leu Glu Arg Ile Ser Ala Thr 
65                  70                  75                  80  


Asp Pro Asp Gly Leu His Ala Gly Val Val Thr Phe Gln Val Val Gly 
                85                  90                  95      


Asp Glu Glu Ser Gln Arg Tyr Phe Gln Val Val Asn Asp Gly Ala Asn 
            100                 105                 110         


Leu Gly Ser Leu Arg Leu Leu Gln Ala Val Pro Glu Glu Ile Arg Glu 
        115                 120                 125             


Phe Arg Ile Thr Ile Arg Ala Thr Asp Gln Gly Thr Asp Pro Gly Pro 
    130                 135                 140                 


Leu Ser Thr Asp Met Thr Phe Arg Val Val Phe Val Pro Thr Gln Gly 
145                 150                 155                 160 


Glu Pro Arg Phe Ala Ser Ser Glu His Ala Val Ala Phe Ile Glu Lys 
                165                 170                 175     


Ser Ala Gly Met Glu Glu Ser His Gln Leu Pro Leu Ala Gln Asp Ile 
            180                 185                 190         


Lys Asn His Leu Cys Glu Asp Asp Cys His Ser Ile Tyr Tyr Arg Ile 
        195                 200                 205             


Ile Asp Gly Asn Ser Glu Gly His Phe Gly Leu Asp Pro Val Arg Asn 
    210                 215                 220                 


Arg Leu Phe Leu Lys Lys Glu Leu Ile Arg Glu Gln Ser Ala Ser His 
225                 230                 235                 240 


Thr Leu Gln Val Ala Ala Ser Asn Ser Pro Asp Gly Gly Ile Pro Leu 
                245                 250                 255     


Pro Ala Ser Ile Leu Thr Val Thr Val Thr Val Arg Glu Ala Asp Pro 
            260                 265                 270         


Arg Pro Val Phe Met Arg Glu Leu Tyr Thr Ala Gly Ile Ser Thr Ala 
        275                 280                 285             


Asp Ser Ile Gly Arg Glu Leu Leu Arg Leu His Ala Thr Gln Ser Glu 
    290                 295                 300                 


Gly Ala Ala Ile Thr Tyr Ala Ile Asp Tyr Asp Thr Met Val Val Asp 
305                 310                 315                 320 


Pro Ser Leu Glu Ala Val Arg Gln Ser Ala Phe Val Leu Asn Ala Gln 
                325                 330                 335     


Thr Gly Val Leu Thr Leu Asn Ile Gln Pro Thr Ala Thr Met His Gly 
            340                 345                 350         


Leu Phe Lys Phe Glu Val Thr Ala Thr Asp Thr Ala Gly Ala Gln Asp 
        355                 360                 365             


Arg Thr Asp Val Thr Val Tyr Val Val Ser Ser Gln Asn Arg Leu Glu 
    370                 375                 380                 


His His His His His His 
385                 390 


<210>  21
<211>  1173
<212>  DNA
<213>  Manduca sexta

<400>  21
atggacctca agggatattg ggggacgtac gctatacata tacgggcatt cgaccacggc     60

attccgcaaa tgtccatgaa cgagacatat gagctgatta tccatccgtt caactactac    120

gcgcctgagt tcgtcttccc gaccaacgat gccgtcatac gacttgcgag ggaacgagct    180

gtaatcaatg gagttctagc gacagtgaac ggagagttct tggagcggat atcggcgact    240

gacccggacg gactccacgc gggcgtcgtc accttccaag tggtaggcga tgaggaatca    300

caacggtact ttcaagtagt taacgatggc gcgaacctcg gctcgttgag gttactgcaa    360

gccgttccag aggagatcag ggagttccgg ataacgattc gcgctacaga ccagggaacg    420

gacccaggac cgctgtccac ggacatgacg ttcagagttg tttttgtgcc cacgcaagga    480

gaacctagat tcgcgtcctc agaacatgct gtcgctttca tagaaaagag tgccggcatg    540

gaagagtctc accaacttcc tctagcacaa gacatcaaga accatctctg tgaagacgac    600

tgtcacagca tttactatcg tattatcgat ggcaacagcg agggtcattt cggcctggat    660

cctgttcgca acaggttgtt cctgaagaaa gagctgataa gagaacaaag tgcctcccac    720

actctgcaag tggcggctag taactcgccc gatggtggca ttccacttcc tgcttccatc    780

cttactgtca ctgttaccgt gagggaggca gaccctcgtc cagtgtttat gagggaattg    840

tacaccgcag ggatatccac agcggactcc atcggcagag agctgctcag attacatgcg    900

acccagtctg aaggcgcggc cattacttat gctatagact acgatacaat ggtagtggac    960

cccagcctgg aggcagtgag acagtcggct ttcgtactga acgctcaaac cggagtgctg   1020

acgcttaata tccagcccac ggccacgatg catggactgt tcaaattcga agtcacagct   1080

actgacacgg ccggcgctca ggaccgcacc gacgtcaccg tgtacgtggt atcctcgcag   1140

aaccgcctcg agcaccacca ccaccaccac tga                                1173


<210>  22
<211>  675
<212>  DNA
<213>  Manduca sexta


<220>
<221>  CDS
<222>  (1)..(672)

<400>  22
atg cac cat gct gtc gct ttc ata gaa aag agt gcc ggc atg gaa gag       48
Met His His Ala Val Ala Phe Ile Glu Lys Ser Ala Gly Met Glu Glu         
1               5                   10                  15              

tct cac caa ctt cct cta gca caa gac atc aag aac cat ctc tgt gaa       96
Ser His Gln Leu Pro Leu Ala Gln Asp Ile Lys Asn His Leu Cys Glu         
            20                  25                  30                  

gac gac tgt cac agc att tac tat cgt att atc gat ggc aac agc gag      144
Asp Asp Cys His Ser Ile Tyr Tyr Arg Ile Ile Asp Gly Asn Ser Glu         
        35                  40                  45                      

ggt cat ttc ggc ctg gat cct gtt cgc aac agg ttg ttc ctg aag aaa      192
Gly His Phe Gly Leu Asp Pro Val Arg Asn Arg Leu Phe Leu Lys Lys         
    50                  55                  60                          

gag ctg ata aga gaa caa agt gcc tcc cac act ctg caa gtg gcg gct      240
Glu Leu Ile Arg Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala         
65                  70                  75                  80          

agt aac tcg ccc gat ggt ggc att cca ctt cct gct tcc atc ctt act      288
Ser Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr         
                85                  90                  95              

gtc act gtt acc gtg agg gag gca gac cct cgt cca gtg ttt atg agg      336
Val Thr Val Thr Val Arg Glu Ala Asp Pro Arg Pro Val Phe Met Arg         
            100                 105                 110                 

gaa ttg tac acc gca ggg ata tcc aca gcg gac tcc atc ggc aga gag      384
Glu Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu         
        115                 120                 125                     

ctg ctc aga tta cat gcg acc cag tct gaa ggc gcg gcc att act tat      432
Leu Leu Arg Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr         
    130                 135                 140                         

gct ata gac tac gat aca atg gta gtg gac ccc agc ctg gag gca gtg      480
Ala Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val         
145                 150                 155                 160         

aga cag tcg gct ttc gta ctg aac gct caa acc gga gtg ctg acg ctt      528
Arg Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu         
                165                 170                 175             

aat atc cag ccc acg gcc acg atg cat gga ctg ttc aaa ttc gaa gtc      576
Asn Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val         
            180                 185                 190                 

aca gct act gac acg gcc ggc gct cag gac cgc acc gac gtc acc gtg      624
Thr Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val         
        195                 200                 205                     

tac gtg gta tcc tcg cag aac cgc ctc gag cac cac cac cac cac cac      672
Tyr Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His         
    210                 215                 220                         

tga                                                                  675


<210>  23
<211>  224
<212>  PRT
<213>  Manduca sexta

<400>  23

Met His His Ala Val Ala Phe Ile Glu Lys Ser Ala Gly Met Glu Glu 
1               5                   10                  15      


Ser His Gln Leu Pro Leu Ala Gln Asp Ile Lys Asn His Leu Cys Glu 
            20                  25                  30          


Asp Asp Cys His Ser Ile Tyr Tyr Arg Ile Ile Asp Gly Asn Ser Glu 
        35                  40                  45              


Gly His Phe Gly Leu Asp Pro Val Arg Asn Arg Leu Phe Leu Lys Lys 
    50                  55                  60                  


Glu Leu Ile Arg Glu Gln Ser Ala Ser His Thr Leu Gln Val Ala Ala 
65                  70                  75                  80  


Ser Asn Ser Pro Asp Gly Gly Ile Pro Leu Pro Ala Ser Ile Leu Thr 
                85                  90                  95      


Val Thr Val Thr Val Arg Glu Ala Asp Pro Arg Pro Val Phe Met Arg 
            100                 105                 110         


Glu Leu Tyr Thr Ala Gly Ile Ser Thr Ala Asp Ser Ile Gly Arg Glu 
        115                 120                 125             


Leu Leu Arg Leu His Ala Thr Gln Ser Glu Gly Ala Ala Ile Thr Tyr 
    130                 135                 140                 


Ala Ile Asp Tyr Asp Thr Met Val Val Asp Pro Ser Leu Glu Ala Val 
145                 150                 155                 160 


Arg Gln Ser Ala Phe Val Leu Asn Ala Gln Thr Gly Val Leu Thr Leu 
                165                 170                 175     


Asn Ile Gln Pro Thr Ala Thr Met His Gly Leu Phe Lys Phe Glu Val 
            180                 185                 190         


Thr Ala Thr Asp Thr Ala Gly Ala Gln Asp Arg Thr Asp Val Thr Val 
        195                 200                 205             


Tyr Val Val Ser Ser Gln Asn Arg Leu Glu His His His His His His 
    210                 215                 220                 


<210>  24
<211>  675
<212>  DNA
<213>  Manduca sexta

<400>  24
atgcaccatg ctgtcgcttt catagaaaag agtgccggca tggaagagtc tcaccaactt     60

cctctagcac aagacatcaa gaaccatctc tgtgaagacg actgtcacag catttactat    120

cgtattatcg atggcaacag cgagggtcat ttcggcctgg atcctgttcg caacaggttg    180

ttcctgaaga aagagctgat aagagaacaa agtgcctccc acactctgca agtggcggct    240

agtaactcgc ccgatggtgg cattccactt cctgcttcca tccttactgt cactgttacc    300

gtgagggagg cagaccctcg tccagtgttt atgagggaat tgtacaccgc agggatatcc    360

acagcggact ccatcggcag agagctgctc agattacatg cgacccagtc tgaaggcgcg    420

gccattactt atgctataga ctacgataca atggtagtgg accccagcct ggaggcagtg    480

agacagtcgg ctttcgtact gaacgctcaa accggagtgc tgacgcttaa tatccagccc    540

acggccacga tgcatggact gttcaaattc gaagtcacag ctactgacac ggccggcgct    600

caggaccgca ccgacgtcac cgtgtacgtg gtatcctcgc agaaccgcct cgagcaccac    660

caccaccacc actga                                                     675


<210>  25
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB9 version of Spodoptera frugiperda cadherin repeats


<220>
<221>  CDS
<222>  (1)..(957)

<400>  25
atg aaa ttc ctg gac cgt ctg tcc gca act gac gaa gac ggc ctg cac       48
Met Lys Phe Leu Asp Arg Leu Ser Ala Thr Asp Glu Asp Gly Leu His         
1               5                   10                  15              

gcg ggc cgt gta act ttc tct atc gct ggc aac gac gag gct gca gaa       96
Ala Gly Arg Val Thr Phe Ser Ile Ala Gly Asn Asp Glu Ala Ala Glu         
            20                  25                  30                  

tac ttc aac gtt ctg aac gac ggc gat aac tcc gct atg ctg acc ctg      144
Tyr Phe Asn Val Leu Asn Asp Gly Asp Asn Ser Ala Met Leu Thr Leu         
        35                  40                  45                      

aaa cag gcg ctg ccg gct ggt gta cag cag ttc gaa ctg gtg att cgc      192
Lys Gln Ala Leu Pro Ala Gly Val Gln Gln Phe Glu Leu Val Ile Arg         
    50                  55                  60                          

gct act gac ggc ggt acc gaa ccg ggc ccg cgt tct acc gac tgt agc      240
Ala Thr Asp Gly Gly Thr Glu Pro Gly Pro Arg Ser Thr Asp Cys Ser         
65                  70                  75                  80          

gta acc gtt gtt ttc gtt atg acc cag ggt gac ccg gtt ttc gac gat      288
Val Thr Val Val Phe Val Met Thr Gln Gly Asp Pro Val Phe Asp Asp         
                85                  90                  95              

aac gca gca tct gtt cgc ttt gta gaa aag gaa gca ggt atg tcc gaa      336
Asn Ala Ala Ser Val Arg Phe Val Glu Lys Glu Ala Gly Met Ser Glu         
            100                 105                 110                 

aag ttc cag ctg cca cag gct gat gac ccg aag aac tat cgt tgt atg      384
Lys Phe Gln Leu Pro Gln Ala Asp Asp Pro Lys Asn Tyr Arg Cys Met         
        115                 120                 125                     

gac gac tgc cac act att tac tac tcc atc gtt gac ggt aac gac ggt      432
Asp Asp Cys His Thr Ile Tyr Tyr Ser Ile Val Asp Gly Asn Asp Gly         
    130                 135                 140                         

gac cac ttc gca gtt gaa ccg gag acc aac gta atc tac ctg ctg aaa      480
Asp His Phe Ala Val Glu Pro Glu Thr Asn Val Ile Tyr Leu Leu Lys         
145                 150                 155                 160         

ccg ctg gac cgt tct cag cag gaa cag tat cgt gtt gtt gta gca gca      528
Pro Leu Asp Arg Ser Gln Gln Glu Gln Tyr Arg Val Val Val Ala Ala         
                165                 170                 175             

tcc aac acc cca ggt ggc act agt act ctg tct tcc tcc ctg ctg acc      576
Ser Asn Thr Pro Gly Gly Thr Ser Thr Leu Ser Ser Ser Leu Leu Thr         
            180                 185                 190                 

gtt act atc ggt gta cgt gaa gcg aat ccg cgt ccg att ttc gaa tcc      624
Val Thr Ile Gly Val Arg Glu Ala Asn Pro Arg Pro Ile Phe Glu Ser         
        195                 200                 205                     

gaa ttt tac acc gcg ggt gta ctg cac acc gac tcc atc cac aaa gaa      672
Glu Phe Tyr Thr Ala Gly Val Leu His Thr Asp Ser Ile His Lys Glu         
    210                 215                 220                         

ctg gtt tat ctg gcg gca aaa cac agc gaa ggt ctg cca atc gtt tac      720
Leu Val Tyr Leu Ala Ala Lys His Ser Glu Gly Leu Pro Ile Val Tyr         
225                 230                 235                 240         

tct att gac cag gaa acc atg aaa att gat gaa tca ctg cag act gtt      768
Ser Ile Asp Gln Glu Thr Met Lys Ile Asp Glu Ser Leu Gln Thr Val         
                245                 250                 255             

gta gaa gat gcg ttc gac atc aac tcc gct acc ggt gtt atc tct ctg      816
Val Glu Asp Ala Phe Asp Ile Asn Ser Ala Thr Gly Val Ile Ser Leu         
            260                 265                 270                 

aac ttc cag cct acc agc gtt atg cat ggc agc ttc gat ttc gaa gtt      864
Asn Phe Gln Pro Thr Ser Val Met His Gly Ser Phe Asp Phe Glu Val         
        275                 280                 285                     

gtt gca tct gac acc cgc ggc gct agc gac cgt gcc aaa gta agc att      912
Val Ala Ser Asp Thr Arg Gly Ala Ser Asp Arg Ala Lys Val Ser Ile         
    290                 295                 300                         

tac atg atc tct acc cgc gtt cgc gta cac cac cac cat cac cac taa      960
Tyr Met Ile Ser Thr Arg Val Arg Val His His His His His His             
305                 310                 315                             


<210>  26
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BtB9 version of Spodoptera frugiperda cadherin repeats

<400>  26

Met Lys Phe Leu Asp Arg Leu Ser Ala Thr Asp Glu Asp Gly Leu His 
1               5                   10                  15      


Ala Gly Arg Val Thr Phe Ser Ile Ala Gly Asn Asp Glu Ala Ala Glu 
            20                  25                  30          


Tyr Phe Asn Val Leu Asn Asp Gly Asp Asn Ser Ala Met Leu Thr Leu 
        35                  40                  45              


Lys Gln Ala Leu Pro Ala Gly Val Gln Gln Phe Glu Leu Val Ile Arg 
    50                  55                  60                  


Ala Thr Asp Gly Gly Thr Glu Pro Gly Pro Arg Ser Thr Asp Cys Ser 
65                  70                  75                  80  


Val Thr Val Val Phe Val Met Thr Gln Gly Asp Pro Val Phe Asp Asp 
                85                  90                  95      


Asn Ala Ala Ser Val Arg Phe Val Glu Lys Glu Ala Gly Met Ser Glu 
            100                 105                 110         


Lys Phe Gln Leu Pro Gln Ala Asp Asp Pro Lys Asn Tyr Arg Cys Met 
        115                 120                 125             


Asp Asp Cys His Thr Ile Tyr Tyr Ser Ile Val Asp Gly Asn Asp Gly 
    130                 135                 140                 


Asp His Phe Ala Val Glu Pro Glu Thr Asn Val Ile Tyr Leu Leu Lys 
145                 150                 155                 160 


Pro Leu Asp Arg Ser Gln Gln Glu Gln Tyr Arg Val Val Val Ala Ala 
                165                 170                 175     


Ser Asn Thr Pro Gly Gly Thr Ser Thr Leu Ser Ser Ser Leu Leu Thr 
            180                 185                 190         


Val Thr Ile Gly Val Arg Glu Ala Asn Pro Arg Pro Ile Phe Glu Ser 
        195                 200                 205             


Glu Phe Tyr Thr Ala Gly Val Leu His Thr Asp Ser Ile His Lys Glu 
    210                 215                 220                 


Leu Val Tyr Leu Ala Ala Lys His Ser Glu Gly Leu Pro Ile Val Tyr 
225                 230                 235                 240 


Ser Ile Asp Gln Glu Thr Met Lys Ile Asp Glu Ser Leu Gln Thr Val 
                245                 250                 255     


Val Glu Asp Ala Phe Asp Ile Asn Ser Ala Thr Gly Val Ile Ser Leu 
            260                 265                 270         


Asn Phe Gln Pro Thr Ser Val Met His Gly Ser Phe Asp Phe Glu Val 
        275                 280                 285             


Val Ala Ser Asp Thr Arg Gly Ala Ser Asp Arg Ala Lys Val Ser Ile 
    290                 295                 300                 


Tyr Met Ile Ser Thr Arg Val Arg Val His His His His His His 
305                 310                 315                 


<210>  27
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB9 version of Spodoptera frugiperda cadherin repeats

<400>  27
atgaaattcc tggaccgtct gtccgcaact gacgaagacg gcctgcacgc gggccgtgta     60

actttctcta tcgctggcaa cgacgaggct gcagaatact tcaacgttct gaacgacggc    120

gataactccg ctatgctgac cctgaaacag gcgctgccgg ctggtgtaca gcagttcgaa    180

ctggtgattc gcgctactga cggcggtacc gaaccgggcc cgcgttctac cgactgtagc    240

gtaaccgttg ttttcgttat gacccagggt gacccggttt tcgacgataa cgcagcatct    300

gttcgctttg tagaaaagga agcaggtatg tccgaaaagt tccagctgcc acaggctgat    360

gacccgaaga actatcgttg tatggacgac tgccacacta tttactactc catcgttgac    420

ggtaacgacg gtgaccactt cgcagttgaa ccggagacca acgtaatcta cctgctgaaa    480

ccgctggacc gttctcagca ggaacagtat cgtgttgttg tagcagcatc caacacccca    540

ggtggcacta gtactctgtc ttcctccctg ctgaccgtta ctatcggtgt acgtgaagcg    600

aatccgcgtc cgattttcga atccgaattt tacaccgcgg gtgtactgca caccgactcc    660

atccacaaag aactggttta tctggcggca aaacacagcg aaggtctgcc aatcgtttac    720

tctattgacc aggaaaccat gaaaattgat gaatcactgc agactgttgt agaagatgcg    780

ttcgacatca actccgctac cggtgttatc tctctgaact tccagcctac cagcgttatg    840

catggcagct tcgatttcga agttgttgca tctgacaccc gcggcgctag cgaccgtgcc    900

aaagtaagca tttacatgat ctctacccgc gttcgcgtac accaccacca tcaccactaa    960


<210>  28
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB10 (protease stabilized)


<220>
<221>  CDS
<222>  (1)..(957)

<400>  28
atg gca ttt ctg gat tgt ctg tct gca act gat gaa gat ggt ctg cat       48
Met Ala Phe Leu Asp Cys Leu Ser Ala Thr Asp Glu Asp Gly Leu His         
1               5                   10                  15              

gct ggt tgt gtc acc ttc agt att gct ggc aat gat gag gca gca gaa       96
Ala Gly Cys Val Thr Phe Ser Ile Ala Gly Asn Asp Glu Ala Ala Glu         
            20                  25                  30                  

tat ttt aat gta ctg aat gat ggt gac aac tct gct atg ctg acc ctg      144
Tyr Phe Asn Val Leu Asn Asp Gly Asp Asn Ser Ala Met Leu Thr Leu         
        35                  40                  45                      

tcc cag gct ctg cca gct ggt gtt cag cag ttt gag ctg gtt atc tct      192
Ser Gln Ala Leu Pro Ala Gly Val Gln Gln Phe Glu Leu Val Ile Ser         
    50                  55                  60                          

gct act gat ggt ggt act gaa cca ggc cca tct agc act gac tgc agt      240
Ala Thr Asp Gly Gly Thr Glu Pro Gly Pro Ser Ser Thr Asp Cys Ser         
65                  70                  75                  80          

gtt act gtt gta ttt gtt atg acc cag ggt gac cca gta ttt gat gac      288
Val Thr Val Val Phe Val Met Thr Gln Gly Asp Pro Val Phe Asp Asp         
                85                  90                  95              

aac gca gct tct gtt tcc ttt gtt gaa cat gaa gct ggt atg tct gag      336
Asn Ala Ala Ser Val Ser Phe Val Glu His Glu Ala Gly Met Ser Glu         
            100                 105                 110                 

tcc ttc cag ctg cca cag gct gat gac cca tct aac tat gct tgt atg      384
Ser Phe Gln Leu Pro Gln Ala Asp Asp Pro Ser Asn Tyr Ala Cys Met         
        115                 120                 125                     

gat gac tgc cac act atc tac tac tct att gta gat ggt aac gat ggt      432
Asp Asp Cys His Thr Ile Tyr Tyr Ser Ile Val Asp Gly Asn Asp Gly         
    130                 135                 140                         

gat cat ttt gct gtt gaa cca gaa acc aac gta att tat ctg ctg agc      480
Asp His Phe Ala Val Glu Pro Glu Thr Asn Val Ile Tyr Leu Leu Ser         
145                 150                 155                 160         

cca ctg gac tct tct cag cag gaa cag tac tct gta gtt gtt gca gct      528
Pro Leu Asp Ser Ser Gln Gln Glu Gln Tyr Ser Val Val Val Ala Ala         
                165                 170                 175             

tcc aac acc cca ggt ggt aca tcc acc ctg tct tct tcc ctg ctg act      576
Ser Asn Thr Pro Gly Gly Thr Ser Thr Leu Ser Ser Ser Leu Leu Thr         
            180                 185                 190                 

gtt act att ggt gta tct gaa gct aac cca tcc ccg atc ttt gaa agt      624
Val Thr Ile Gly Val Ser Glu Ala Asn Pro Ser Pro Ile Phe Glu Ser         
        195                 200                 205                     

gaa ttt tac act gct ggt gtt ctg cac act gac tct att cat tct gaa      672
Glu Phe Tyr Thr Ala Gly Val Leu His Thr Asp Ser Ile His Ser Glu         
    210                 215                 220                         

ctg gtt tac ctg gca gct tct cac tct gaa ggt ctc cca att gta tat      720
Leu Val Tyr Leu Ala Ala Ser His Ser Glu Gly Leu Pro Ile Val Tyr         
225                 230                 235                 240         

tct att gac cag gaa act atg tca att gat gaa tct ctg cag act gtg      768
Ser Ile Asp Gln Glu Thr Met Ser Ile Asp Glu Ser Leu Gln Thr Val         
                245                 250                 255             

gtg gaa gat gct ttc gac atc aac tct gca act ggt gtt atc tcc ctg      816
Val Glu Asp Ala Phe Asp Ile Asn Ser Ala Thr Gly Val Ile Ser Leu         
            260                 265                 270                 

aac ttc cag cca act tct gtt atg cat ggt agc ttt gac ttt gaa gta      864
Asn Phe Gln Pro Thr Ser Val Met His Gly Ser Phe Asp Phe Glu Val         
        275                 280                 285                     

gtt gct tct gac act tgt ggt gca tct gac tgt gct tct gtt tcc atc      912
Val Ala Ser Asp Thr Cys Gly Ala Ser Asp Cys Ala Ser Val Ser Ile         
    290                 295                 300                         

tac atg atc tcc acc cgt gtt aga gtt cac cac cac cac cac cac taa      960
Tyr Met Ile Ser Thr Arg Val Arg Val His His His His His His             
305                 310                 315                             


<210>  29
<211>  319
<212>  PRT
<213>  Artificial sequence

<220>
<223>  BtB10 (protease stabilized)

<400>  29

Met Ala Phe Leu Asp Cys Leu Ser Ala Thr Asp Glu Asp Gly Leu His 
1               5                   10                  15      


Ala Gly Cys Val Thr Phe Ser Ile Ala Gly Asn Asp Glu Ala Ala Glu 
            20                  25                  30          


Tyr Phe Asn Val Leu Asn Asp Gly Asp Asn Ser Ala Met Leu Thr Leu 
        35                  40                  45              


Ser Gln Ala Leu Pro Ala Gly Val Gln Gln Phe Glu Leu Val Ile Ser 
    50                  55                  60                  


Ala Thr Asp Gly Gly Thr Glu Pro Gly Pro Ser Ser Thr Asp Cys Ser 
65                  70                  75                  80  


Val Thr Val Val Phe Val Met Thr Gln Gly Asp Pro Val Phe Asp Asp 
                85                  90                  95      


Asn Ala Ala Ser Val Ser Phe Val Glu His Glu Ala Gly Met Ser Glu 
            100                 105                 110         


Ser Phe Gln Leu Pro Gln Ala Asp Asp Pro Ser Asn Tyr Ala Cys Met 
        115                 120                 125             


Asp Asp Cys His Thr Ile Tyr Tyr Ser Ile Val Asp Gly Asn Asp Gly 
    130                 135                 140                 


Asp His Phe Ala Val Glu Pro Glu Thr Asn Val Ile Tyr Leu Leu Ser 
145                 150                 155                 160 


Pro Leu Asp Ser Ser Gln Gln Glu Gln Tyr Ser Val Val Val Ala Ala 
                165                 170                 175     


Ser Asn Thr Pro Gly Gly Thr Ser Thr Leu Ser Ser Ser Leu Leu Thr 
            180                 185                 190         


Val Thr Ile Gly Val Ser Glu Ala Asn Pro Ser Pro Ile Phe Glu Ser 
        195                 200                 205             


Glu Phe Tyr Thr Ala Gly Val Leu His Thr Asp Ser Ile His Ser Glu 
    210                 215                 220                 


Leu Val Tyr Leu Ala Ala Ser His Ser Glu Gly Leu Pro Ile Val Tyr 
225                 230                 235                 240 


Ser Ile Asp Gln Glu Thr Met Ser Ile Asp Glu Ser Leu Gln Thr Val 
                245                 250                 255     


Val Glu Asp Ala Phe Asp Ile Asn Ser Ala Thr Gly Val Ile Ser Leu 
            260                 265                 270         


Asn Phe Gln Pro Thr Ser Val Met His Gly Ser Phe Asp Phe Glu Val 
        275                 280                 285             


Val Ala Ser Asp Thr Cys Gly Ala Ser Asp Cys Ala Ser Val Ser Ile 
    290                 295                 300                 


Tyr Met Ile Ser Thr Arg Val Arg Val His His His His His His 
305                 310                 315                 


<210>  30
<211>  960
<212>  DNA
<213>  Artificial sequence

<220>
<223>  BtB10 (protease stabilized)

<400>  30
atggcatttc tggattgtct gtctgcaact gatgaagatg gtctgcatgc tggttgtgtc     60

accttcagta ttgctggcaa tgatgaggca gcagaatatt ttaatgtact gaatgatggt    120

gacaactctg ctatgctgac cctgtcccag gctctgccag ctggtgttca gcagtttgag    180

ctggttatct ctgctactga tggtggtact gaaccaggcc catctagcac tgactgcagt    240

gttactgttg tatttgttat gacccagggt gacccagtat ttgatgacaa cgcagcttct    300

gtttcctttg ttgaacatga agctggtatg tctgagtcct tccagctgcc acaggctgat    360

gacccatcta actatgcttg tatggatgac tgccacacta tctactactc tattgtagat    420

ggtaacgatg gtgatcattt tgctgttgaa ccagaaacca acgtaattta tctgctgagc    480

ccactggact cttctcagca ggaacagtac tctgtagttg ttgcagcttc caacacccca    540

ggtggtacat ccaccctgtc ttcttccctg ctgactgtta ctattggtgt atctgaagct    600

aacccatccc cgatctttga aagtgaattt tacactgctg gtgttctgca cactgactct    660

attcattctg aactggttta cctggcagct tctcactctg aaggtctccc aattgtatat    720

tctattgacc aggaaactat gtcaattgat gaatctctgc agactgtggt ggaagatgct    780

ttcgacatca actctgcaac tggtgttatc tccctgaact tccagccaac ttctgttatg    840

catggtagct ttgactttga agtagttgct tctgacactt gtggtgcatc tgactgtgct    900

tctgtttcca tctacatgat ctccacccgt gttagagttc accaccacca ccaccactaa    960


