                         SEQUENCE LISTING

<110>  SUTKOWSKI, NATALIE
       RUBINCHIK, SEMYON
 
<120>  HUMAN MONOCLONAL ANTIBODIES AND METHODS FOR PRODUCING THE SAME

<130>  MESC:022WO

<140>  UNKNOWN
<141>  2008-08-04

<150>  60/953,739
<151>  2007-08-03

<160>  71    

<170>  PatentIn version 3.3

<210>  1
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  1
tctagacagt ctgtgytgac kcagccgccc tca                                  33


<210>  2
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  2
tctagacagt ctgcgctgac tcarccgscc tct                                  33


<210>  3
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  3
tctagatcct atgaactgac tcagccaccy t                                    31


<210>  4
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  4
tctagatctg aactgactca gccdscctc                                       29


<210>  5
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  5
tctagatctg aactgactca ggaccctgyt                                      30


<210>  6
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  6
tctagaratt ttatgctgac tcagccccac tct                                  33


<210>  7
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  7
gtcgacagag gasggyggga acagagtgac                                      30


<210>  8
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  8
tctagacatc srgatgaccc agtctcc                                         27


<210>  9
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  9
tctagatatt gtgatgacyc agwctccact ct                                   32


<210>  10
<211>  28
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  10
tctagaaatt gtrwtgacrc agtctcca                                        28


<210>  11
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  11
gtcgacgaag acagatggtg cagccacagt                                      30


<210>  12
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  12
tctagasagg tgcagctggt gcagtct                                         27


<210>  13
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  13
tctagacagg trcagctgca gsagtc                                          26


<210>  14
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  14
tctagaggtg cagctgktgg agtct                                           25


<210>  15
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  15
gtcgacsgat gggcccttgg tgga                                            24


<210>  16
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa can be any naturally occurring amino acid

<400>  16

Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln Arg Val 
1               5                   10                  15      


Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val 
            20                  25                  30          


Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile Tyr 
        35                  40                  45              


Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln Ser Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly 
                85                  90                  95      


Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Asn Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Xaa 
        115                 120         


<210>  17
<211>  365
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  17
gtgttgacgc agccgccctc agcgtctggg acccccgggc agagggtcac catctcttgt     60

tctggaagca gctccaacat cggaagtaat actgtaaact ggtaccagca gctcccagga    120

acggccccca aactcctcat ctatagtaat aatcagcggc cctcaggggt ccctgaccga    180

ttctctggct ccaagtctgg cacctcagcc tccctggcca tcagtgggct ccagtctgag    240

gatgaggctg attattactg tgcagcatgg gatgacagcc tgaatggtcc ggtgttcggc    300

ggaaccaagc tgaccgtcct aggtcagccc aaggctgccc cctcggtcac tctgttcccg    360

ccctc                                                                365


<210>  18
<211>  287
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  18
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcagctc    120

ccaggaacgg cccccaaact cctcatctat agtataatca gcggccctca ggggtccctg    180

accgattctc tggctccaag tctggcacct cagcctccct ggccatcagt gggctccagt    240

ctgaggatga ggctgattat tactgtgcag catgggatga cagcctg                  287


<210>  19
<211>  128
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (125)..(125)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (128)..(128)
<223>  Xaa can be any naturally occurring amino acid

<400>  19

Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln Lys Val Thr 
1               5                   10                  15      


Ile Ser Cys Thr Gly Ser Gln Ser Val Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr His Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu Asn Gly Tyr Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Asn Pro Thr Val Thr Leu Phe Xaa Pro Ser Xaa 
        115                 120                 125             


<210>  20
<211>  374
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (366)..(366)
<223>  n is a, c, g, or t

<400>  20
gttgacgcag ccgccctcag tgtctggggc cccagggcag aaggtcacca tctcctgcac     60

tgggagcagc tccaacatcg gggcaggtta tgatgtacac tggtaccagc agcttccagg    120

aacagccccc aaactcctca tctatggtaa cagcaatcgg ccctcagggg tccctgaccg    180

attctctggc tccaagtctg gcacctcagc ctccctggcc atcactgggc tccaggctga    240

ggatgaggct gattatcact gccagtccta cgacagcagc ctgaatggtt attatgtctt    300

cggaactggg accaaggtca ccgtcctagg tcagcccaag gccaacccca ctgtcactct    360

gttccnccct cctc                                                      374


<210>  21
<211>  291
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  21
cagtctgtgc tgacgcagcc gccctcagtg tctggggccc cagggcagaa ggtcaccatc     60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactg gtaccagcag    120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc    180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc    240

caggctgagg atgaggctga ttattactgc cagtcctacg acagcagcct g             291


<210>  22
<211>  117
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<400>  22

Arg Xaa Gly Gly Gly Leu Val Gln Pro Gly Gly Ser Leu Arg Leu Ser 
1               5                   10                  15      


Cys Ala Ala Ser Arg Phe Thr Phe Ser Arg Tyr Ala Met Asn Trp Val 
            20                  25                  30          


Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Ser Ile Thr Gly 
        35                  40                  45              


Ser Gly Gly Arg Thr Phe Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr 
    50                  55                  60                  


Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser 
65                  70                  75                  80  


Leu Arg Ala Glu Asp Thr Ala Leu Tyr Tyr Cys Ala Lys Pro Pro Thr 
                85                  90                  95      


Val Thr Thr Gly Asp Pro Phe Asp Ile Trp Gly Gln Gly Thr Met Val 
            100                 105                 110         


Thr Val Ser Ser Pro 
        115         


<210>  23
<211>  352
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<400>  23
gccggggngg gggaggcttg gtacagcctg gggggtccct gagactctcc tgtgcagcct     60

ctagattcac ctttagcaga tatgccatga actgggtccg ccaggctcca gggaaggggc    120

tggagtgggt ctcatctatt actggtagtg gtggtaggac attttatgca gactccgtga    180

agggccgctt caccatctcc agagacaatt ccaagaacac attgtatctg caaatgaaca    240

gcctgagagc cgaggacacg gccctttatt actgtgcgaa accccctacg gtgactacgg    300

ggatcctttt gatatctggg gccaagggac aatggtcacc gtctcttcac cc            352


<210>  24
<211>  294
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  24
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaa          294


<210>  25
<211>  134
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  25

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Asn Asn 
            20                  25                  30          


Tyr Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Val Ile Tyr Ser Gly Gly Ser Arg Tyr Tyr Pro Glu Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Tyr Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Ser Cys Asn Ser Thr Ser Cys His Pro Val Tyr Val Arg Thr 
            100                 105                 110         


Thr Val Trp Thr Ser Gly Ala Lys Gly Pro Gln Ser Pro Ser Pro Gln 
        115                 120                 125             


Pro Pro Pro Arg Ala His 
    130                 


<210>  26
<211>  403
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  26
gaggtgcagc tggtgcagtc tggaggaggc ttgatccagc cgggggggtc cctaagactc     60

tcctgtgcag cctctgggtt caccgtcagt aacaactaca tcagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagtt atttatagcg gtggtagtag atactaccca    180

gagtccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt    240

caaatgaaca gcctgagagt cgaggacacg cccgtgtatt actgtgcgag ggtttcttgt    300

aatagtacca gctgtcatcc cgtgtacgta cgtactacgg tatggacgtc tggggccaag    360

ggaccacagt caccgtctcc tcagcctcca ccaagggccc atc                      403


<210>  27
<211>  291
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  27
gaggtgcagc tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggctt caccgtcagt agcaactaca tgagctgggt ccgccaggct    120

ccagggaagg ggctgcagtg ggtctcagtt atttatagcg gtggtagcac atactacgca    180

gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt    240

caaatgaaca gcctgagagc cgaggacacg cccgtgtatt actgtgcgag a             291


<210>  28
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  28

Ser Ser Asn Ile Gly Ser Asn Thr Ser Asn Asn Ala Ala Trp Asp Asp 
1               5                   10                  15      


Ser Leu Asn Gly Pro Val 
            20          


<210>  29
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  29

Ser Ser Asn Ile Gly Ala Gly Tyr Asp Gly Asn Ser Gln Ser Tyr Asp 
1               5                   10                  15      


Ser Ser Leu Asn Gly Tyr Tyr Val 
            20                  


<210>  30
<211>  31
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  30

Arg Phe Thr Phe Ser Arg Tyr Ala Ile Thr Gly Ser Gly Gly Arg Thr 
1               5                   10                  15      


Ala Lys Pro Pro Thr Val Thr Thr Gly Asp Pro Phe Asp Ile Trp 
            20                  25                  30      


<210>  31
<211>  48
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  31

Gly Phe Thr Val Ser Asn Asn Tyr Ile Tyr Ser Gly Gly Ser Arg Ala 
1               5                   10                  15      


Arg Val Ser Cys Asn Ser Thr Ser Cys His Pro Val Tyr Val Arg Thr 
            20                  25                  30          


Thr Val Trp Thr Ser Gly Ala Lys Gly Pro Gln Ser Pro Ser Pro Gln 
        35                  40                  45              


<210>  32
<211>  121
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  32

Val Ser Ala Ala Pro Gly Gln Lys Pro Thr Ile Ser Cys Ser Gly Ser 
1               5                   10                  15      


Ser Ser Asn Ile Gly Thr Asp Tyr Val Ser Trp Gln Gln Leu Pro Gly 
            20                  25                  30          


Thr Ala Pro Lys Leu Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Met 
        35                  40                  45              


Pro Asp Arg Phe Ser Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile 
    50                  55                  60                  


Thr Gly Leu Gln Thr Gly Asp Glu Ala Asp Tyr Tyr Gly Thr Trp Asp 
65                  70                  75                  80  


Ser Ser Leu Asn Gly Pro Val Val Phe Gly Gly Gly Thr Lys Leu Thr 
                85                  90                  95      


Val Leu Gly His His Ala Ala Ala Ser Val Thr Leu Phe Leu Pro Ser 
            100                 105                 110         


Ser Pro Asp Val Thr Ile Lys Ile Lys 
        115                 120     


<210>  33
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  33
gtgtctgcgg ccccaggaca gaaggtcacc atctcctgct ctggaagcag ctccaacatt     60

gggactgatt atgtatcctg gtaccagcag ctcccaggaa cagcccccaa actcatctat    120

gataataata agcgaccctc agggatgcct gaccgattct cttccaagtc tggcacctca    180

gccaccctgg gcatcaccgg actccagact ggggatgagg ctgattatta cggaacatgg    240

gatagcagcc tgaatggtcc tgtggtattc ggcggaggga ccaagctgac cgtcctaggt    300

catcatgctg ccgcctccgt cactctgttt ctgccatcct ctgttgacgt ctttattaaa    360

attaaa                                                               366


<210>  34
<211>  109
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  34

Gln Ser Val Leu Thr Gln Phe Pro Ser Val Ser Ala Ala Pro Gly Gln 
1               5                   10                  15      


Lys Pro Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Met 
            20                  25                  30          


Val Ser Trp Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Ile Tyr Leu 
        35                  40                  45              


Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Ser Lys Ser 
    50                  55                  60                  


Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr Gly Asp Glu 
65                  70                  75                  80  


Ala Asp Tyr Tyr Gly Thr Trp Asp Ser Ser Leu Asn Gly Pro Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly His His 
            100                 105                 


<210>  35
<211>  333
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  35
cagtctgtgt tgacgcagcc gccctcagtg tctgcggccc caggacagaa ggtcaccatc     60

tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta ccagcagctc    120

ccaggaacag cccccaaact catctatgaa aataataagc gacgctcagg gattcctgac    180

cgattctctt ccaagtctgg cacgtcagcc accctgggca tcaccggact ccagactggg    240

gacgaggccg attattacgg aacatgggat agcagcctga atggtcctgt ggtattcggc    300

ggagggacca agctgaccgt cctaggtcat cat                                 333


<210>  36
<211>  95
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  36

Ser Ser Ala Phe Ser Ser Leu Ala Met Ser Trp Val Arg Gln Ala Pro 
1               5                   10                  15      


Gly Gln Gly Leu Glu Trp Val Ser Ala Ile Ile Gly Ser Gly Gly Ser 
            20                  25                  30          


Thr Tyr Tyr Ala Asp Ser Val Lys Gly Asp Phe Thr Ile Ser Arg Asp 
        35                  40                  45              


Asn Ser Lys Asn Thr Pro Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
    50                  55                  60                  


Thr Ala Pro Tyr Tyr Cys Leu Lys Thr Pro Thr Cys Thr Thr Gly Val 
65                  70                  75                  80  


Leu Leu Asp Tyr Cys Gly Gln Gly Thr Leu Val Ser Val Ser Ser 
                85                  90                  95  


<210>  37
<211>  289
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  37
tagcagcgcc ttcagcagct tggccatgag ctgggtccgc caggctccag ggcaggggct     60

ggagtgggtg tcagctatca ttggtagtgg tggtagcaca tattatgcag actctgtgaa    120

gggccgcttc accatctcca gagacaattc caagaacaca ccgtatcttc aaatgaacag    180

cctgagagcc gaggacacgg ccgtgtatta ctgtttgaaa acccctacgt gcactacggg    240

ggttctctta gactactgcg gccaggggac cctggtctcc gtctcctcc                289


<210>  38
<211>  288
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  n is a, c, g, or t

<400>  38
tcaacacaac ggttcccagt tacatccatg ttgtttcaaa cagcggggtc cctgagagtc     60

tcgtgtgcag cgtcnggatt cacctttagc agctatgcca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcacgatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggcggtat attactgt                 288


<210>  39
<211>  23
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  39

Ser Ser Asn Ile Gly Thr Asp Tyr Asp Asn Asn Gly Thr Trp Asp Ser 
1               5                   10                  15      


Ser Leu Asn Gly Pro Cys Val 
            20              


<210>  40
<211>  35
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  40

Ser Ser Ala Phe Ser Ser Leu Ala Ile Ile Gly Ser Gly Gly Ser Thr 
1               5                   10                  15      


Leu Lys Thr Pro Thr Cys Thr Thr Gly Val Leu Leu Asp Tyr Cys Gly 
            20                  25                  30          


Gln Gly Thr 
        35  


<210>  41
<211>  41
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  41
aaaaaaaagc ggccgccatg gaatacctat tgcctacggc a                         41


<210>  42
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  42
aaaaaaagcg gccgccatgg cctggtctcc tctcctcctc                           40


<210>  43
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  43
aaaaaaagga tcctawgarc attctgyagg ggccactgt                            39


<210>  44
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  44
aaaaaagcgg ccgccatgga gtttgggctg agctgggttt tc                        42


<210>  45
<211>  43
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  45
aaaaaagcgg ccgccatgga gtttgggctg agctggcttt ttc                       43


<210>  46
<211>  39
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  46
aaaaaaagga tcctcattta cccrgagaca gggagaggc                            39


<210>  47
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  47

Val Ser Gly Ala Pro Gly Gln Lys Val Thr Ile Ser Cys Ser Gly Ser 
1               5                   10                  15      


Ser Ser Asn Ile Gly Ala Gly Tyr Asp Val His Cys Tyr Gln Leu Leu 
            20                  25                  30          


Gln Gly Thr Ala Pro Lys Leu Leu Ile Tyr Gly Asn Ser Tyr Arg Pro 
        35                  40                  45              


Ser Gly Val Asp Asp Arg Phe Cys Gly Ser Lys Ser Gly Thr Ser Ala 
    50                  55                  60                  


Leu Val Val Ile Ser Gly Leu His Ala Asp Asp Asp Ala Asp Tyr Cys 
65                  70                  75                  80  


Cys Gln Ser Tyr Asp Ser Ile Leu Asp Gly Tyr Tyr Val Phe Gly Thr 
                85                  90                  95      


Gly Thr Lys Val Thr Val Leu Arg Gln Ala Ala 
            100                 105         


<210>  48
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  48
gtgtctgggg ccccagggca gaaggtcacc atctcctgct ctggaagcag ctccaacatc     60

ggggctggtt atgatgtaca ctgctaccag ctgcttcaag gaacagcccc caaactcctc    120

atttatggta acagctatcg gccctcaggg gtcgatgacc gattctgtgg ctccaagtct    180

ggcacctcag ccttggtggt catcagtggg ctccatgctg atgatgatgc tgattattgc    240

tgccagtcct acgacagcat cctggatggt tattatgtct tcggaactgg gaccaaggtc    300

accgtcctac gtcaggctgc g                                              321


<210>  49
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  49

Gln Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Thr Gly Ser Ser Ser Asn Ile Gly Ala Gly 
            20                  25                  30          


Tyr Asp Val His Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu 
        35                  40                  45              


Leu Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Ser 
                85                  90                  95      


Leu 
    


<210>  50
<211>  291
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  50
cagtctgtcg tgacgcagcc gccctcagtg tctggggccc cagggcagag ggtcaccatc     60

tcctgcactg ggagcagctc caacatcggg gcaggttatg atgtacactw ctaccagcag    120

cttccaggaa cagcccccaa actcctcatc tatggtaaca gcaatcggcc ctcaggggtc    180

cctgaccgat tctctggctc caagtctggc acctcagcct ccctggccat cactgggctc    240

caggctgagg atgaggctga ttattactgc cagtcctatg acagcagcct g             291


<210>  51
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa can be any naturally occurring amino acid

<400>  51

Xaa Leu Lys Pro Phe Xaa Ala Glu Val Lys Lys Pro Gly Ala Ser Val 
1               5                   10                  15      


Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr Cys Ile 
            20                  25                  30          


Trp Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Ser 
        35                  40                  45              


Ile Asn Pro Ile Asp Gly Ala Ile Asn Tyr Ala Gln Lys Phe Gln Gly 
    50                  55                  60                  


Lys Val Thr Ile Ser Ala Asp Lys Ser Ile Ser Thr Ala Tyr Met Gln 
65                  70                  75                  80  


Leu Ser Ser Leu Lys Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 
                85                  90                  95      


Glu 
    


<210>  52
<211>  289
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  n is a, c, g, or t

<400>  52
tttaaagcct ttcanggcag aggtgaagaa gcctggggcc tctgtgaagg tctcctgcaa     60

ggcttctgga tacaccttca ccagctattg tatcaactgg gtgcgacagg cgcctggaca    120

agggctggag tggatgggaa gcatcaatcc tattgacggt gcaacaaact acgcacagaa    180

gttccagggc aaagtcacca tttcagcgga caagtccatc agcacagcct acatgcagtt    240

gagcagcctg aaagctgagg acacggccgt gtattactgt gcgagagag                289


<210>  53
<211>  97
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  53

Gln Val Gln Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser Ser 
1               5                   10                  15      


Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ser Tyr Ala 
            20                  25                  30          


Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly 
        35                  40                  45              


Arg Ile Ile Pro Ile Leu Gly Ile Ala Asn Tyr Ala Gln Lys Phe Gln 
    50                  55                  60                  


Gly Arg Val Thr Ile Thr Ala Asp Lys Ser Thr Ser Thr Ala Tyr Met 
65                  70                  75                  80  


Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg 
    


<210>  54
<211>  294
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  54
caggtccagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc     60

tcctgcaagg cttctggagg caccttcagc agctatgcta tcagctgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggaagg atcatcccta tccttggtat agcaaactac    180

gcacagaagt tccagggcag agtcacgatt accgcggaca aatccacgag cacagcctac    240

atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc gaga          294


<210>  55
<211>  122
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  55

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser Val Thr Leu Phe 
        115                 120         


<210>  56
<211>  366
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  56
tcctatgaac tgactcagcc accttcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcagctc    120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag    240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtccggtg    300

ttcggcggag ggaccaagct gaccgtccta ggtcagccca aggctgcccc ctcggtcact    360

ctgttc                                                               366


<210>  57
<211>  96
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  57

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


<210>  58
<211>  288
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  58
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc     60

tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcagctc    120

ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct    180

gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccag    240

tctgaggatg aggctgatta ttactgtgca gcatgggatg acagcctg                 288


<210>  59
<211>  108
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  59

Val Ser Glu Ser Pro Gly Lys Thr Val Thr Ile Ser Cys Thr Arg Ser 
1               5                   10                  15      


Ser Gly Ser Ile Ala Ser Asn Tyr Val Gln Trp Tyr Gln Gln Arg Pro 
            20                  25                  30          


Gly Ser Ser Pro Thr Thr Val Ile Tyr Glu Asp Asn Gln Arg Pro Ser 
        35                  40                  45              


Gly Val Pro Asp Arg Phe Ser Gly Ser Ile Asp Ser Ser Ser Asn Ser 
    50                  55                  60                  


Ala Ser Leu Thr Ile Ser Gly Leu Lys Thr Glu Asp Glu Ala Asp Tyr 
65                  70                  75                  80  


Tyr Cys Gln Ser Tyr Asp Ser Ser Asn Trp Val Phe Gly Gly Gly Thr 
                85                  90                  95      


Lys Leu Thr Val Leu Ser Gln Pro Lys Ala Ala Pro 
            100                 105             


<210>  60
<211>  324
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  60
gtgtcggagt ctccggggaa gacggtaacc atctcctgca cccgcagcag tggcagcatt     60

gccagcaact atgtgcagtg gtaccagcag cgcccgggca gttcccccac cactgtgatc    120

tatgaggata accaaagacc ctctggggtc cctgatcggt tctctggctc catcgacagc    180

tcctccaact ctgcctccct caccatctct ggactgaaga ctgaggacga ggctgactac    240

tactgtcagt cttatgatag cagcaattgg gtgttcggcg gagggaccaa gctgaccgtc    300

ctaagtcagc ccaaggctgc cccc                                           324


<210>  61
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  61

Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 
1               5                   10                  15      


Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Ser Asn 
            20                  25                  30          


Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 
        35                  40                  45              


Ile Tyr Glu Asp Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Ile Asp Ser Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 
65                  70                  75                  80  


Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser 
                85                  90                  95      


Ser Asn 
        


<210>  62
<211>  294
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  62
aattttatgc tgactcagcc ccactctgtg tcggagtctc cggggaagac ggtaaccatc     60

tcctgcaccc gcagcagtgg cagcattgcc agcaactatg tgcagtggta ccagcagcgc    120

ccgggcagtt cccccaccac tgtgatctat gaggataacc aaagaccctc tggggtccct    180

gatcggttct ctggctccat cgacagctcc tccaactctg cctccctcac catctctgga    240

ctgaagactg aggacgaggc tgactactac tgtcagtctt atgatagcag caat          294


<210>  63
<211>  126
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  63

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Glu 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser His 
            20                  25                  30          


Pro Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Asp Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Thr Gly Arg Phe Ile Ile Ser Arg Asp Asn Ser Glu Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Pro Phe Cys Phe Gly Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Asp Phe Phe 
        115                 120                 125     


<210>  64
<211>  378
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  64
gaggtgcagc tggtgcagtc tgggggaggc ttggtacagc ctggggagtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc agccatccca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtgatga cacatactac    180

gcagactccg tgacgggccg gttcatcatc tccagagaca attccgagaa tacgctgtat    240

ctgcaaatga gcagcctgag agccgaggac acggccgtat attactgtgc gaaagggggg    300

ccgttttgct tcgggggcca gggaaccctg gtcaccgtct cctcagcctc caccaagggc    360

ccatcgtgcg actttttt                                                  378


<210>  65
<211>  98
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  65

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys 
        


<210>  66
<211>  294
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic primer

<400>  66
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gaaa          294


<210>  67
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  67

Ser Ser Asn Ile Gly Ala Gly Tyr Asp Gly Asn Ser Gln Ser Tyr Asp 
1               5                   10                  15      


Ser Ile Leu Asp Gly Tyr Tyr Val 
            20                  


<210>  68
<211>  22
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  68

Ser Ser Asn Ile Gly Ser Asn Thr Ser Asn Asn Ala Ala Trp Asp Asp 
1               5                   10                  15      


Ser Leu Asn Gly Pro Val 
            20          


<210>  69
<211>  20
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  69

Ser Gly Ser Ile Ala Ser Asn Tyr Glu Asp Asn Gln Ser Tyr Asp Ser 
1               5                   10                  15      


Ser Asn Trp Val 
            20  


<210>  70
<211>  18
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  70

Gly Tyr Thr Phe Thr Ser Tyr Cys Ile Asn Pro Ile Asp Gly Ala Thr 
1               5                   10                  15      


Ala Arg 
        


<210>  71
<211>  27
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  71

Gly Phe Thr Phe Ser Ser His Pro Ile Ser Gly Ser Gly Asp Asp Thr 
1               5                   10                  15      


Ala Lys Gly Gly Pro Phe Cys Phe Gly Gly Gln 
            20                  25          


