                         SEQUENCE LISTING

<110>  Alba Therapeutics Corporation
 
<120>  NOVEL PEPTIDES THAT ENHANCE TIGHT JUNCTION PERMEABILITY

<130>  ALBA-001/04WO

<140>  PCT/US2008/071321
<141>  2008-07-28

<150>  US 60/952,144
<151>  2007-07-26

<150>  US 60/953,398
<151>  2007-08-01

<150>  US 60/953,403
<151>  2007-08-01

<150>  US 60/953,405
<151>  2007-08-01

<160>  274    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  1

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  2
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -OH moiety

<400>  2

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  3
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  3

Phe Xaa Ile Gly Arg 
1               5   


<210>  4
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is D-allylglycine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  4

Phe Xaa Ile Gly Arg 
1               5   


<210>  5
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  5

Met Xaa Ile Gly Arg Leu 
1               5       


<210>  6
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  6

Gln Xaa Ile Gly Arg Leu 
1               5       


<210>  7
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  7

Leu Xaa Ile Gly Arg Leu 
1               5       


<210>  8
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  8

Ser Xaa Ile Gly Arg Leu 
1               5       


<210>  9
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  9

Thr Xaa Ile Gly Arg Leu 
1               5       


<210>  10
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  10

Glu Xaa Ile Gly Arg Leu 
1               5       


<210>  11
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  11

Val Xaa Ile Gly Arg Leu 
1               5       


<210>  12
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  12

Tyr Xaa Ile Gly Arg Leu 
1               5       


<210>  13
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  13

Gly Xaa Ile Gly Arg Leu 
1               5       


<210>  14
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  14

Asp Xaa Ile Gly Arg Leu 
1               5       


<210>  15
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  15

Trp Xaa Ile Gly Arg Leu 
1               5       


<210>  16
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  16

Lys Xaa Ile Gly Arg Leu 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  17

Ala Xaa Ile Gly Arg Leu 
1               5       


<210>  18
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  18

His Xaa Ile Gly Arg Leu 
1               5       


<210>  19
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  19

Pro Xaa Ile Gly Arg Leu 
1               5       


<210>  20
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  20

Arg Xaa Ile Gly Arg Leu 
1               5       


<210>  21
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  21

Ile Xaa Ile Gly Arg Leu 
1               5       


<210>  22
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  22

Phe Xaa Pro Gly Arg Leu 
1               5       


<210>  23
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  23

Phe Xaa Phe Gly Arg Leu 
1               5       


<210>  24
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  24

Phe Xaa Thr Gly Arg Leu 
1               5       


<210>  25
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  25

Phe Xaa Leu Gly Arg Leu 
1               5       


<210>  26
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  26

Phe Xaa Ser Gly Arg Leu 
1               5       


<210>  27
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  27

Phe Xaa Phe Gly Arg Leu 
1               5       


<210>  28
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  28

Phe Xaa Val Gly Arg Leu 
1               5       


<210>  29
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  29

Phe Xaa Gly Gly Arg Leu 
1               5       


<210>  30
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  30

Phe Xaa Ala Gly Arg Leu 
1               5       


<210>  31
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  31

Phe Xaa His Gly Arg Leu 
1               5       


<210>  32
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  32

Phe Xaa Asp Gly Arg Leu 
1               5       


<210>  33
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  33

Phe Xaa Glu Gly Arg Leu 
1               5       


<210>  34
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  34

Phe Xaa Gln Gly Arg Leu 
1               5       


<210>  35
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  35

Phe Xaa Arg Gly Arg Leu 
1               5       


<210>  36
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  36

Phe Xaa Lys Gly Arg Leu 
1               5       


<210>  37
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  37

Phe Xaa Asn Gly Arg Leu 
1               5       


<210>  38
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  38

Phe Xaa Tyr Gly Arg Leu 
1               5       


<210>  39
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  39

Phe Xaa Ile Thr Arg Leu 
1               5       


<210>  40
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  40

Phe Xaa Ile Leu Arg Leu 
1               5       


<210>  41
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  41

Phe Xaa Ile Ile Arg Leu 
1               5       


<210>  42
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  42

Phe Xaa Ile Ala Arg Leu 
1               5       


<210>  43
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  43

Phe Xaa Ile Pro Arg Leu 
1               5       


<210>  44
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  44

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  45
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  45

Phe Xaa Ile His Arg Leu 
1               5       


<210>  46
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  46

Phe Xaa Ile Asp Arg Leu 
1               5       


<210>  47
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  47

Phe Xaa Ile Glu Arg Leu 
1               5       


<210>  48
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  48

Phe Xaa Ile Gln Arg Leu 
1               5       


<210>  49
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  49

Phe Xaa Ile Phe Arg Leu 
1               5       


<210>  50
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  50

Phe Xaa Ile Arg Arg Leu 
1               5       


<210>  51
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  51

Phe Xaa Ile Lys Arg Leu 
1               5       


<210>  52
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  52

Phe Xaa Ile Asn Arg Leu 
1               5       


<210>  53
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  53

Phe Xaa Ile Ser Arg Leu 
1               5       


<210>  54
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  54

Phe Xaa Ile Val Arg Leu 
1               5       


<210>  55
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  55

Phe Xaa Ile Gly His Leu 
1               5       


<210>  56
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  56

Phe Xaa Ile Gly Asp Leu 
1               5       


<210>  57
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  57

Phe Xaa Ile Gly Glu Leu 
1               5       


<210>  58
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  58

Phe Xaa Ile Gly Gln Leu 
1               5       


<210>  59
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  59

Phe Xaa Ile Gly Gly Leu 
1               5       


<210>  60
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  60

Phe Xaa Ile Gly Ala Leu 
1               5       


<210>  61
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  61

Phe Xaa Ile Gly Phe Leu 
1               5       


<210>  62
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  62

Phe Xaa Ile Gly Lys Leu 
1               5       


<210>  63
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  63

Phe Xaa Ile Gly Leu Leu 
1               5       


<210>  64
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  64

Phe Xaa Ile Gly Met Leu 
1               5       


<210>  65
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  65

Phe Xaa Ile Gly Asn Leu 
1               5       


<210>  66
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  66

Phe Xaa Ile Gly Ser Leu 
1               5       


<210>  67
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  67

Phe Xaa Ile Gly Tyr Leu 
1               5       


<210>  68
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  68

Phe Xaa Ile Gly Thr Leu 
1               5       


<210>  69
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  69

Phe Xaa Ile Gly Ile Leu 
1               5       


<210>  70
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  70

Phe Xaa Ile Gly Trp Leu 
1               5       


<210>  71
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  71

Phe Xaa Ile Gly Pro Leu 
1               5       


<210>  72
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  72

Phe Xaa Ile Gly Val Leu 
1               5       


<210>  73
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  His is modified with a C terminal -NH2 moiety

<400>  73

Phe Xaa Ile Gly Arg His 
1               5       


<210>  74
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Asp is modified with a C terminal -NH2 moiety

<400>  74

Phe Xaa Ile Gly Arg Asp 
1               5       


<210>  75
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  75

Phe Xaa Ile Gly Arg Arg 
1               5       


<210>  76
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Phe is modified with a C terminal -NH2 moiety

<400>  76

Phe Xaa Ile Gly Arg Phe 
1               5       


<210>  77
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Ala is modified with a C terminal -NH2 moiety

<400>  77

Phe Xaa Ile Gly Arg Ala 
1               5       


<210>  78
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Gly is modified with a C terminal -NH2 moiety

<400>  78

Phe Xaa Ile Gly Arg Gly 
1               5       


<210>  79
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Gln is modified with a C terminal -NH2 moiety

<400>  79

Phe Xaa Ile Gly Arg Gln 
1               5       


<210>  80
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Glu is modified with a C terminal -NH2 moiety

<400>  80

Phe Xaa Ile Gly Arg Glu 
1               5       


<210>  81
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Thr is modified with a C terminal -NH2 moiety

<400>  81

Phe Xaa Ile Gly Arg Thr 
1               5       


<210>  82
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Tyr is modified with a C terminal -NH2 moiety

<400>  82

Phe Xaa Ile Gly Arg Tyr 
1               5       


<210>  83
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Ser is modified with a C terminal -NH2 moiety

<400>  83

Phe Xaa Ile Gly Arg Ser 
1               5       


<210>  84
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Asn is modified with a C terminal -NH2 moiety

<400>  84

Phe Xaa Ile Gly Arg Asn 
1               5       


<210>  85
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Met is modified with a C terminal -NH2 moiety

<400>  85

Phe Xaa Ile Gly Arg Met 
1               5       


<210>  86
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Lys is modified with a C terminal -NH2 moiety

<400>  86

Phe Xaa Ile Gly Arg Lys 
1               5       


<210>  87
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Ile is modified with a C terminal -NH2 moiety

<400>  87

Phe Xaa Ile Gly Arg Ile 
1               5       


<210>  88
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Trp is modified with a C terminal -NH2 moiety

<400>  88

Phe Xaa Ile Gly Arg Trp 
1               5       


<210>  89
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Pro is modified with a C terminal -NH2 moiety

<400>  89

Phe Xaa Ile Gly Arg Pro 
1               5       


<210>  90
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is allylglycine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Val is modified with a C terminal -NH2 moiety

<400>  90

Phe Xaa Ile Gly Arg Val 
1               5       


<210>  91
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  91

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  92
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  92

Phe Thr Ile Gly Arg Leu 
1               5       


<210>  93
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  93

Phe Ser Ile Gly Arg Leu 
1               5       


<210>  94
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  94

Phe Met Ile Gly Arg Leu 
1               5       


<210>  95
<211>  6
<212>  PRT
<213>  Unknown

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<220>
<223>  Peptide tight junction agonist

<400>  95

Phe Leu Ile Gly Arg Leu 
1               5       


<210>  96
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  96

Phe Phe Leu Ile Gly Arg Leu 
1               5           


<210>  97
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  97

Phe Phe Ile Gly Arg Leu 
1               5       


<210>  98
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  98

Phe Pro Ile Gly Arg Leu 
1               5       


<210>  99
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  99

Phe Trp Ile Gly Arg Leu 
1               5       


<210>  100
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  100

Phe His Ile Gly Arg Leu 
1               5       


<210>  101
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  101

Phe Pro Ile Gly Arg Leu 
1               5       


<210>  102
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  102

Phe Asp Ile Gly Arg Leu 
1               5       


<210>  103
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  103

Phe Leu Ile Gly Arg Leu 
1               5       


<210>  104
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  104

Phe Phe Ile Gly Arg Leu 
1               5       


<210>  105
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  105

Phe Arg Ile Gly Arg Leu 
1               5       


<210>  106
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  106

Phe Gly Ile Gly Arg Leu 
1               5       


<210>  107
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  107

Phe Gln Ile Gly Arg Leu 
1               5       


<210>  108
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  108

Phe Glu Ile Gly Arg Leu 
1               5       


<210>  109
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  109

Phe Lys Ile Gly Arg Leu 
1               5       


<210>  110
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  110

Phe Asn Ile Gly Arg Leu 
1               5       


<210>  111
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  111

Phe Tyr Ile Gly Arg Leu 
1               5       


<210>  112
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  112

Phe Leu Ile Gly Arg Leu 
1               5       


<210>  113
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  113

Phe Val Ile Gly Arg Leu 
1               5       


<210>  114
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  114

Phe Ile Ile Gly Arg Leu 
1               5       


<210>  115
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  115

Ser Leu Ile Gly Arg Leu 
1               5       


<210>  116
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Phe is modified with a C terminal -NH2 moiety

<400>  116

Leu Arg Gly Ile Leu Phe 
1               5       


<210>  117
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  117

Phe Leu Ile Gly Arg 
1               5   


<210>  118
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-beta-(2-thienyl)-alanine

<400>  118

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  119
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<400>  119

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  120
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-alpha-aminobutyric acid

<400>  120

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  121
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-methionine-sulfoxide

<400>  121

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  122
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-methionine-sulfone

<400>  122

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  123
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<400>  123

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  124
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Norvaline

<400>  124

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  125
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-norleucine

<400>  125

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  126
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phe is acetylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<400>  126

Phe Xaa Ile Gly Arg Ala 
1               5       


<210>  127
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phe is acetylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<400>  127

Phe Xaa Ile Gly Arg Ser 
1               5       


<210>  128
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phe is acetylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<400>  128

Phe Xaa Ile Gly Arg Phe 
1               5       


<210>  129
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<400>  129

Phe Xaa Ile Gly Arg Phe 
1               5       


<210>  130
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-S-benzyl-cysteine

<400>  130

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  131
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-S-tert-butylthio-cysteine

<400>  131

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  132
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-phenylglycine

<400>  132

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  133
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Val

<400>  133

Phe Val Ile Gly Arg Leu 
1               5       


<210>  134
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-beta-cyclohexyl-alanine

<400>  134

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  135
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-tert-butylglycine

<400>  135

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  136
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-1,4-diaminobutyric acid

<400>  136

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  137
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-(R,S)-3,4-cis-methanoproline

<400>  137

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  138
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-1,3-diaminopropionic acid

<400>  138

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  139
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-S-acetamidomethyl-penicillamine

<400>  139

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  140
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homocysteine

<400>  140

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  141
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-beta-(2-pyridyl)-alanine

<400>  141

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  142
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  142

Phe Leu Ile Gly Arg Leu 
1               5       


<210>  143
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  143

Phe Leu Ile Gly Arg Leu 
1               5       


<210>  144
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Phe is modified with a C terminal -NH2 moiety

<400>  144

Leu Arg Gly Ile Leu Phe 
1               5       


<210>  145
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-alpha-aminobutyric acid(dimer)

<400>  145

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  146
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is dehydro-leucine or L-4,5-dehydro-leucine

<400>  146

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  147
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phe is acetylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  147

Phe Xaa Ile Gly Arg 
1               5   


<210>  148
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  148

Phe Xaa Ile Gly Arg 
1               5   


<210>  149
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phe is acetylated

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  149

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  150
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homoserine

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<400>  150

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  151
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-4-cyano-phenylalanine

<400>  151

Xaa Phe Ile Gly Arg Leu 
1               5           


<210>  152
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-3-methyl-phenylalanine

<400>  152

Xaa Phe Ile Gly Arg Leu 
1               5           


<210>  153
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-beta-cyclopropyl-alanine

<400>  153

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  154
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-propargylglycine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  154

Phe Xaa Ile Gly Arg 
1               5   


<210>  155
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-beta-(2-furyl)-alanine

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  155

Phe Xaa Ile Gly Arg 
1               5   


<210>  156
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is 1,2,3,4-tetrahydroharmane-3-carboxylic acid

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Arg is modified with a C terminal -NH2 moiety

<400>  156

Phe Xaa Ile Gly Arg 
1               5   


<210>  157
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-beta-styryl-alanine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  157

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  158
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is Homocitrulline

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  158

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  159
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is 1,2,3,4-tetrahydroharmane-3-carboxylic acid

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  159

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  160
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is L-beta-(2-furyl)-alanine

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  160

Phe Xaa Ile Gly Arg Leu 
1               5       


<210>  161
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  161

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  162
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  162

Phe Cys Ala Gly Met Ser 
1               5       


<210>  163
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  163

Phe Cys Val Gly Met Ser 
1               5       


<210>  164
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  164

Pro Cys Ile Gly Arg Leu 
1               5       


<210>  165
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  165

Gln Cys Ile Gly Arg Leu 
1               5       


<210>  166
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  166

Gly Cys Ile Gly Arg Leu 
1               5       


<210>  167
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  167

Thr Cys Ile Gly Arg Leu 
1               5       


<210>  168
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  168

Ser Cys Ile Gly Arg Leu 
1               5       


<210>  169
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  169

Asn Cys Ile Gly Arg Leu 
1               5       


<210>  170
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  170

Arg Cys Ile Gly Arg Leu 
1               5       


<210>  171
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  171

Val Cys Ile Gly Arg Leu 
1               5       


<210>  172
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  172

Phe Cys Ile Gly Arg Gly 
1               5       


<210>  173
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Ala

<400>  173

Ala Cys Ile Gly Arg Gly 
1               5       


<210>  174
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  174

Ala Cys Ile Gly Arg Gly 
1               5       


<210>  175
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  175

Phe Cys Ile Gly Arg Gly 
1               5       


<210>  176
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Phe

<400>  176

Phe Cys Ile Gly Arg Gly 
1               5       


<210>  177
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  177

Phe Cys Ile Gly Arg Ser 
1               5       


<210>  178
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  178

Phe Cys Ile Gly Arg Gln 
1               5       


<210>  179
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  179

Phe Cys Ile Gly Arg Lys 
1               5       


<210>  180
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Ala

<400>  180

Phe Cys Ile Gly Arg Ala 
1               5       


<210>  181
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  181

Phe Cys Ile Gly Arg Ile 
1               5       


<210>  182
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Gly is modified with a C terminal -NH2 moiety

<400>  182

Phe Cys Ile Gly Arg Gly 
1               5       


<210>  183
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  183

Phe Cys Ile Gly Arg Asp 
1               5       


<210>  184
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  184

Phe Cys Ile Gly Arg Glu 
1               5       


<210>  185
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  185

Phe Cys Ile Gly Arg Phe 
1               5       


<210>  186
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  186

Phe Cys Ile Gly Arg Asn 
1               5       


<210>  187
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  187

Phe Cys Ile Gly Arg Pro 
1               5       


<210>  188
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  188

Glu Cys Ile Gly Arg Leu 
1               5       


<210>  189
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  189

Asp Cys Ile Gly Arg Leu 
1               5       


<210>  190
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  190

Lys Cys Ile Gly Arg Leu 
1               5       


<210>  191
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  191

Phe Cys Ile Gly Arg Leu Cys 
1               5           


<210>  192
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  192

Pro Gly Pro Gly Arg Leu 
1               5       


<210>  193
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  193

Phe Cys Ile Pro Gly Pro 
1               5       


<210>  194
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  194

Phe Cys Leu Gly Arg Leu 
1               5       


<210>  195
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  195

Gly Cys Ile Gly Arg Gly 
1               5       


<210>  196
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  196

Tyr Cys Ile Gly Arg Leu 
1               5       


<210>  197
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ala is acetylated

<400>  197

Ala Cys Ile Gly Arg Leu 
1               5       


<210>  198
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  198

Trp Cys Ile Gly Arg Leu 
1               5       


<210>  199
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ala is acetylated

<400>  199

Ala Cys Ile Gly Arg Ser 
1               5       


<210>  200
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Ala is acetylated

<400>  200

Ala Cys Ile Gly Arg Ala 
1               5       


<210>  201
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phe is acetylated

<400>  201

Phe Cys Ile Gly Arg Phe 
1               5       


<210>  202
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  202

Ser Leu Ile Gly Arg Leu 
1               5       


<210>  203
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  203

Phe Cys Ala Gly 
1               


<210>  204
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  204

Phe Cys Gly Gly 
1               


<210>  205
<211>  7
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  205

Gly Phe Cys Ile Gly Arg Leu 
1               5           


<210>  206
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  206

Leu Arg Gly Gly Arg Leu 
1               5       


<210>  207
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  207

Phe Cys Ala Gly Met Ser 
1               5       


<210>  208
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  208

Phe Cys Val Gly Met Ser 
1               5       


<210>  209
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Phe is acetylated

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Leu is modified with a C terminal -NH2 moiety

<400>  209

Phe Leu Ile Gly Arg Leu 
1               5       


<210>  210
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  210

Tyr Ile Gly Ser Arg 
1               5   


<210>  211
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Sarcosine

<400>  211

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  212
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-beta-cyclohexyl-alanine

<400>  212

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  213
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is alpha-aminoisobutyric acid

<400>  213

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  214
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-tert-butylglycine

<400>  214

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  215
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Norvaline

<400>  215

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  216
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Homoserine

<400>  216

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  217
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is Norvaline

<400>  217

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  218
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is beta-Alanine

<400>  218

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  219
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-tert-leucine

<400>  219

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  220
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-N-methyl-alanine

<400>  220

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  221
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-alpha-aminobutyric acid

<400>  221

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  222
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is alpha-aminoisobutyric acid

<400>  222

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  223
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-beta-cyclohexyl-alanine

<400>  223

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  224
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-alpha-aminobutyric acid

<400>  224

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  225
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Orn

<400>  225

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  226
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is Citrulline

<400>  226

Phe Cys Ile Gly Xaa Leu 
1               5       


<210>  227
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-4-nitro-phenylalanine

<400>  227

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  228
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-4-chlorophenylalanine

<400>  228

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  229
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-4-chlorophenylalanine

<400>  229

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  230
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-4-nitro-phenylalanine

<400>  230

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  231
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<400>  231

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  232
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is N-methylated Isoleucine

<400>  232

Phe Cys Xaa Gly Arg Leu 
1               5       


<210>  233
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-beta-(2-thienyl)-alanine

<400>  233

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  234
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is L-beta-(2-thienyl)-alanine

<400>  234

Xaa Cys Ile Gly Arg Leu 
1               5       


<210>  235
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist


<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is L-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid

<400>  235

Phe Cys Ile Gly Arg Xaa 
1               5       


<210>  236
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  236

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  237
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  237

Ala Cys Ile Gly Arg Leu 
1               5       


<210>  238
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  238

Phe Ala Ile Gly Arg Leu 
1               5       


<210>  239
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  239

Phe Cys Ala Gly Arg Leu 
1               5       


<210>  240
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  240

Phe Cys Ile Ala Arg Leu 
1               5       


<210>  241
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  241

Phe Cys Ile Gly Ala Leu 
1               5       


<210>  242
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  242

Phe Cys Ile Gly Arg Ala 
1               5       


<210>  243
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  243

Cys Ile Gly Arg Leu 
1               5   


<210>  244
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  244

Ile Gly Arg Leu 
1               


<210>  245
<211>  5
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  245

Phe Cys Ile Gly Arg 
1               5   


<210>  246
<211>  4
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  246

Phe Cys Ile Gly 
1               


<210>  247
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Phe

<400>  247

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  248
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<400>  248

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  249
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<400>  249

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  250
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Arg

<400>  250

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  251
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is D-Leu

<400>  251

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  252
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Phe

<400>  252

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  253
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Cys

<400>  253

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  254
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Phe

<400>  254

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  255
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Phe

<400>  255

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  256
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Phe

<400>  256

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  257
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Phe

<400>  257

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  258
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<400>  258

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  259
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<400>  259

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  260
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<400>  260

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  261
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  May be D-Ile

<400>  261

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  262
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Cys

<400>  262

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  263
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Phe

<400>  263

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  264
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Phe

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Leu

<400>  264

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  265
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Phe

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Arg

<400>  265

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  266
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Phe

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Leu

<400>  266

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  267
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Phe

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Leu

<400>  267

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  268
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Phe

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Leu

<400>  268

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  269
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  May be D-Ile

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Leu

<400>  269

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  270
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Cys

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Arg

<400>  270

Phe Cys Ile Gly Arg Leu 
1               5       


<210>  271
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<400>  271

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  272
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<400>  272

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  273
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  May be D-Phe

<400>  273

Leu Arg Gly Ile Cys Phe 
1               5       


<210>  274
<211>  6
<212>  PRT
<213>  Unknown

<220>
<223>  Peptide tight junction agonist

<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  May be D-Leu

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  May be D-Arg

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  May be D-Cys

<400>  274

Leu Arg Gly Ile Cys Phe 
1               5       

