                         SEQUENCE LISTING

<110>  California Pacific Medical Center
       Lee, Nancy M.
 
<120>  METHOD TO PREDICT OR DIAGNOSE A GASTROINTESTINAL DISORDER OR 
       DISEASE

<130>  00010-007WO1

<140>  Not yet known
<141>  2008-07-25

<150>  US 60/952,194
<151>  2007-07-26

<160>  88    

<170>  PatentIn version 3.5

<210>  1
<211>  1666
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (102)..(401)

<400>  1
ctccataagg cacaaacttt cagagacagc agagcacaca agcttctagg acaagagcca       60

ggaagaaacc accggaagga accatctcac tgtgtgtaaa c atg act tcc aag ctg      116
                                              Met Thr Ser Lys Leu         
                                              1               5           

gcc gtg gct ctc ttg gca gcc ttc ctg att tct gca gct ctg tgt gaa        164
Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser Ala Ala Leu Cys Glu           
                10                  15                  20                

ggt gca gtt ttg cca agg agt gct aaa gaa ctt aga tgt cag tgc ata        212
Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile           
            25                  30                  35                    

aag aca tac tcc aaa cct ttc cac ccc aaa ttt atc aaa gaa ctg aga        260
Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe Ile Lys Glu Leu Arg           
        40                  45                  50                        

gtg att gag agt gga cca cac tgc gcc aac aca gaa att att gta aag        308
Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr Glu Ile Ile Val Lys           
    55                  60                  65                            

ctt tct gat gga aga gag ctc tgt ctg gac ccc aag gaa aac tgg gtg        356
Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro Lys Glu Asn Trp Val           
70                  75                  80                  85            

cag agg gtt gtg gag aag ttt ttg aag agg gct gag aat tca taa            401
Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala Glu Asn Ser                   
                90                  95                                    

aaaaattcat tctctgtggt atccaagaat cagtgaagat gccagtgaaa cttcaagcaa      461

atctacttca acacttcatg tattgtgtgg gtctgttgta gggttgccag atgcaataca      521

agattcctgg ttaaatttga atttcagtaa acaatgaata gtttttcatt gtaccatgaa      581

atatccagaa catacttata tgtaaagtat tatttatttg aatctacaaa aaacaacaaa      641

taatttttaa atataaggat tttcctagat attgcacggg agaatataca aatagcaaaa      701

ttgaggccaa gggccaagag aatatccgaa ctttaatttc aggaattgaa tgggtttgct      761

agaatgtgat atttgaagca tcacataaaa atgatgggac aataaatttt gccataaagt      821

caaatttagc tggaaatcct ggattttttt ctgttaaatc tggcaaccct agtctgctag      881

ccaggatcca caagtccttg ttccactgtg ccttggtttc tcctttattt ctaagtggaa      941

aaagtattag ccaccatctt acctcacagt gatgttgtga ggacatgtgg aagcacttta     1001

agttttttca tcataacata aattattttc aagtgtaact tattaaccta tttattattt     1061

atgtatttat ttaagcatca aatatttgtg caagaatttg gaaaaataga agatgaatca     1121

ttgattgaat agttataaag atgttatagt aaatttattt tattttagat attaaatgat     1181

gttttattag ataaatttca atcagggttt ttagattaaa caaacaaaca attgggtacc     1241

cagttaaatt ttcatttcag ataaacaaca aataattttt tagtataagt acattattgt     1301

ttatctgaaa ttttaattga actaacaatc ctagtttgat actcccagtc ttgtcattgc     1361

cagctgtgtt ggtagtgctg tgttgaatta cggaataatg agttagaact attaaaacag     1421

ccaaaactcc acagtcaata ttagtaattt cttgctggtt gaaacttgtt tattatgtac     1481

aaatagattc ttataatatt atttaaatga ctgcattttt aaatacaagg ctttatattt     1541

ttaactttaa gatgttttta tgtgctctcc aaattttttt tactgtttct gattgtatgg     1601

aaatataaaa gtaaatatga aacatttaaa atataatttg ttgtcaaagt aaaaaaaaaa     1661

aaaaa                                                                 1666


<210>  2
<211>  99
<212>  PRT
<213>  homo sapiens

<400>  2

Met Thr Ser Lys Leu Ala Val Ala Leu Leu Ala Ala Phe Leu Ile Ser 
1               5                   10                  15      


Ala Ala Leu Cys Glu Gly Ala Val Leu Pro Arg Ser Ala Lys Glu Leu 
            20                  25                  30          


Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro Phe His Pro Lys Phe 
        35                  40                  45              


Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro His Cys Ala Asn Thr 
    50                  55                  60                  


Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu Leu Cys Leu Asp Pro 
65                  70                  75                  80  


Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys Phe Leu Lys Arg Ala 
                85                  90                  95      


Glu Asn Ser 
            


<210>  3
<211>  2098
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (79)..(573)

<400>  3
cctgccgaag tcagttcctt gtggagccgg agctgggcgc ggattcgccg aggcaccgag       60

gcactcagag gaggcgcc atg tca gaa ccg gct ggg gat gtc cgt cag aac        111
                    Met Ser Glu Pro Ala Gly Asp Val Arg Gln Asn           
                    1               5                   10                

cca tgc ggc agc aag gcc tgc cgc cgc ctc ttc ggc cca gtg gac agc        159
Pro Cys Gly Ser Lys Ala Cys Arg Arg Leu Phe Gly Pro Val Asp Ser           
            15                  20                  25                    

gag cag ctg agc cgc gac tgt gat gcg cta atg gcg ggc tgc atc cag        207
Glu Gln Leu Ser Arg Asp Cys Asp Ala Leu Met Ala Gly Cys Ile Gln           
        30                  35                  40                        

gag gcc cgt gag cga tgg aac ttc gac ttt gtc acc gag aca cca ctg        255
Glu Ala Arg Glu Arg Trp Asn Phe Asp Phe Val Thr Glu Thr Pro Leu           
    45                  50                  55                            

gag ggt gac ttc gcc tgg gag cgt gtg cgg ggc ctt ggc ctg ccc aag        303
Glu Gly Asp Phe Ala Trp Glu Arg Val Arg Gly Leu Gly Leu Pro Lys           
60                  65                  70                  75            

ctc tac ctt ccc acg ggg ccc cgg cga ggc cgg gat gag ttg gga gga        351
Leu Tyr Leu Pro Thr Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly           
                80                  85                  90                

ggc agg cgg cct ggc acc tca cct gct ctg ctg cag ggg aca gca gag        399
Gly Arg Arg Pro Gly Thr Ser Pro Ala Leu Leu Gln Gly Thr Ala Glu           
            95                  100                 105                   

gaa gac cat gtg gac ctg tca ctg tct tgt acc ctt gtg cct cgc tca        447
Glu Asp His Val Asp Leu Ser Leu Ser Cys Thr Leu Val Pro Arg Ser           
        110                 115                 120                       

ggg gag cag gct gaa ggg tcc cca ggt gga cct gga gac tct cag ggt        495
Gly Glu Gln Ala Glu Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly           
    125                 130                 135                           

cga aaa cgg cgg cag acc agc atg aca gat ttc tac cac tcc aaa cgc        543
Arg Lys Arg Arg Gln Thr Ser Met Thr Asp Phe Tyr His Ser Lys Arg           
140                 145                 150                 155           

cgg ctg atc ttc tcc aag agg aag ccc taa tccgcccaca ggaagcctgc          593
Arg Leu Ile Phe Ser Lys Arg Lys Pro                                       
                160                                                       

agtcctggaa gcgcgagggc ctcaaaggcc cgctctacat cttctgcctt agtctcagtt      653

tgtgtgtctt aattattatt tgtgttttaa tttaaacacc tcctcatgta cataccctgg      713

ccgccccctg ccccccagcc tctggcatta gaattattta aacaaaaact aggcggttga      773

atgagaggtt cctaagagtg ctgggcattt ttattttatg aaatactatt taaagcctcc      833

tcatcccgtg ttctcctttt cctctctccc ggaggttggg tgggccggct tcatgccagc      893

tacttcctcc tccccacttg tccgctgggt ggtaccctct ggaggggtgt ggctccttcc      953

catcgctgtc acaggcggtt atgaaattca ccccctttcc tggacactca gacctgaatt     1013

ctttttcatt tgagaagtaa acagatggca ctttgaaggg gcctcaccga gtgggggcat     1073

catcaaaaac tttggagtcc cctcacctcc tctaaggttg ggcagggtga ccctgaagtg     1133

agcacagcct agggctgagc tggggacctg gtaccctcct ggctcttgat acccccctct     1193

gtcttgtgaa ggcaggggga aggtggggtc ctggagcaga ccaccccgcc tgccctcatg     1253

gcccctctga cctgcactgg ggagcccgtc tcagtgttga gccttttccc tctttggctc     1313

ccctgtacct tttgaggagc cccagctacc cttcttctcc agctgggctc tgcaattccc     1373

ctctgctgct gtccctcccc cttgtccttt cccttcagta ccctctcagc tccaggtggc     1433

tctgaggtgc ctgtcccacc cccaccccca gctcaatgga ctggaagggg aagggacaca     1493

caagaagaag ggcaccctag ttctacctca ggcagctcaa gcagcgaccg ccccctcctc     1553

tagctgtggg ggtgagggtc ccatgtggtg gcacaggccc ccttgagtgg ggttatctct     1613

gtgttagggg tatatgatgg gggagtagat ctttctagga gggagacact ggcccctcaa     1673

atcgtccagc gaccttcctc atccacccca tccctcccca gttcattgca ctttgattag     1733

cagcggaaca aggagtcaga cattttaaga tggtggcagt agaggctatg gacagggcat     1793

gccacgtggg ctcatatggg gctgggagta gttgtctttc ctggcactaa cgttgagccc     1853

ctggaggcac tgaagtgctt agtgtacttg gagtattggg gtctgacccc aaacaccttc     1913

cagctcctgt aacatactgg cctggactgt tttctctcgg ctccccatgt gtcctggttc     1973

ccgtttctcc acctagactg taaacctctc gagggcaggg accacaccct gtactgttct     2033

gtgtctttca cagctcctcc cacaatgctg atatacagca ggtgctcaat aaacgattct     2093

tagtg                                                                 2098


<210>  4
<211>  164
<212>  PRT
<213>  homo sapiens

<400>  4

Met Ser Glu Pro Ala Gly Asp Val Arg Gln Asn Pro Cys Gly Ser Lys 
1               5                   10                  15      


Ala Cys Arg Arg Leu Phe Gly Pro Val Asp Ser Glu Gln Leu Ser Arg 
            20                  25                  30          


Asp Cys Asp Ala Leu Met Ala Gly Cys Ile Gln Glu Ala Arg Glu Arg 
        35                  40                  45              


Trp Asn Phe Asp Phe Val Thr Glu Thr Pro Leu Glu Gly Asp Phe Ala 
    50                  55                  60                  


Trp Glu Arg Val Arg Gly Leu Gly Leu Pro Lys Leu Tyr Leu Pro Thr 
65                  70                  75                  80  


Gly Pro Arg Arg Gly Arg Asp Glu Leu Gly Gly Gly Arg Arg Pro Gly 
                85                  90                  95      


Thr Ser Pro Ala Leu Leu Gln Gly Thr Ala Glu Glu Asp His Val Asp 
            100                 105                 110         


Leu Ser Leu Ser Cys Thr Leu Val Pro Arg Ser Gly Glu Gln Ala Glu 
        115                 120                 125             


Gly Ser Pro Gly Gly Pro Gly Asp Ser Gln Gly Arg Lys Arg Arg Gln 
    130                 135                 140                 


Thr Ser Met Thr Asp Phe Tyr His Ser Lys Arg Arg Leu Ile Phe Ser 
145                 150                 155                 160 


Lys Arg Lys Pro 
                


<210>  5
<211>  3083
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (162)..(2390)

<400>  5
aaaaactgca gccaacttcc gaggcagcct cattgcccag cggaccccag cctctgccag       60

gttcggtccg ccatcctcgt cccgtcctcc gccggcccct gccccgcgcc cagggatcct      120

ccagctcctt tcgcccgcgc cctccgttcg ctccggacac c atg gac aag ttt tgg      176
                                              Met Asp Lys Phe Trp         
                                              1               5           

tgg cac gca gcc tgg gga ctc tgc ctc gtg ccg ctg agc ctg gcg cag        224
Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro Leu Ser Leu Ala Gln           
                10                  15                  20                

atc gat ttg aat ata acc tgc cgc ttt gca ggt gta ttc cac gtg gag        272
Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly Val Phe His Val Glu           
            25                  30                  35                    

aaa aat ggt cgc tac agc atc tct cgg acg gag gcc gct gac ctc tgc        320
Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu Ala Ala Asp Leu Cys           
        40                  45                  50                        

aag gct ttc aat agc acc ttg ccc aca atg gcc cag atg gag aaa gct        368
Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala Gln Met Glu Lys Ala           
    55                  60                  65                            

ctg agc atc gga ttt gag acc tgc agg tat ggg ttc ata gaa ggg cac        416
Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly Phe Ile Glu Gly His           
70                  75                  80                  85            

gtg gtg att ccc cgg atc cac ccc aac tcc atc tgt gca gca aac aac        464
Val Val Ile Pro Arg Ile His Pro Asn Ser Ile Cys Ala Ala Asn Asn           
                90                  95                  100               

aca ggg gtg tac atc ctc aca tcc aac acc tcc cag tat gac aca tat        512
Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser Gln Tyr Asp Thr Tyr           
            105                 110                 115                   

tgc ttc aat gct tca gct cca cct gaa gaa gat tgt aca tca gtc aca        560
Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp Cys Thr Ser Val Thr           
        120                 125                 130                       

gac ctg ccc aat gcc ttt gat gga cca att acc ata act att gtt aac        608
Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr Ile Thr Ile Val Asn           
    135                 140                 145                           

cgt gat ggc acc cgc tat gtc cag aaa gga gaa tac aga acg aat cct        656
Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu Tyr Arg Thr Asn Pro           
150                 155                 160                 165           

gaa gac atc tac ccc agc aac cct act gat gat gac gtg agc agc ggc        704
Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp Asp Val Ser Ser Gly           
                170                 175                 180               

tcc tcc agt gaa agg agc agc act tca gga ggt tac atc ttt tac acc        752
Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly Tyr Ile Phe Tyr Thr           
            185                 190                 195                   

ttt tct act gta cac ccc atc cca gac gaa gac agt ccc tgg atc acc        800
Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp Ser Pro Trp Ile Thr           
        200                 205                 210                       

gac agc aca gac aga atc cct gct acc act ttg atg agc act agt gct        848
Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu Met Ser Thr Ser Ala           
    215                 220                 225                           

aca gca act gag aca gca acc aag agg caa gaa acc tgg gat tgg ttt        896
Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu Thr Trp Asp Trp Phe           
230                 235                 240                 245           

tca tgg ttg ttt cta cca tca gag tca aag aat cat ctt cac aca aca        944
Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn His Leu His Thr Thr           
                250                 255                 260               

aca caa atg gct ggt acg tct tca aat acc atc tca gca ggc tgg gag        992
Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile Ser Ala Gly Trp Glu           
            265                 270                 275                   

cca aat gaa gaa aat gaa gat gaa aga gac aga cac ctc agt ttt tct       1040
Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg His Leu Ser Phe Ser           
        280                 285                 290                       

gga tca ggc att gat gat gat gaa gat ttt atc tcc agc acc att tca       1088
Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile Ser Ser Thr Ile Ser           
    295                 300                 305                           

acc aca cca cgg gct ttt gac cac aca aaa cag aac cag gac tgg acc       1136
Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln Asn Gln Asp Trp Thr           
310                 315                 320                 325           

cag tgg aac cca agc cat tca aat ccg gaa gtg cta ctt cag aca acc       1184
Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val Leu Leu Gln Thr Thr           
                330                 335                 340               

aca agg atg act gat gta gac aga aat ggc acc act gct tat gaa gga       1232
Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr Thr Ala Tyr Glu Gly           
            345                 350                 355                   

aac tgg aac cca gaa gca cac cct ccc ctc att cac cat gag cat cat       1280
Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile His His Glu His His           
        360                 365                 370                       

gag gaa gaa gag acc cca cat tct aca agc aca atc cag gca act cct       1328
Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr Ile Gln Ala Thr Pro           
    375                 380                 385                           

agt agt aca acg gaa gaa aca gct acc cag aag gaa cag tgg ttt ggc       1376
Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys Glu Gln Trp Phe Gly           
390                 395                 400                 405           

aac aga tgg cat gag gga tat cgc caa aca ccc aaa gaa gac tcc cat       1424
Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro Lys Glu Asp Ser His           
                410                 415                 420               

tcg aca aca ggg aca gct gca gcc tca gct cat acc agc cat cca atg       1472
Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His Thr Ser His Pro Met           
            425                 430                 435                   

caa gga agg aca aca cca agc cca gag gac agt tcc tgg act gat ttc       1520
Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser Ser Trp Thr Asp Phe           
        440                 445                 450                       

ttc aac cca atc tca cac ccc atg gga cga ggt cat caa gca gga aga       1568
Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly His Gln Ala Gly Arg           
    455                 460                 465                           

agg atg gat atg gac tcc agt cat agt ata acg ctt cag cct act gca       1616
Arg Met Asp Met Asp Ser Ser His Ser Ile Thr Leu Gln Pro Thr Ala           
470                 475                 480                 485           

aat cca aac aca ggt ttg gtg gaa gat ttg gac agg aca gga cct ctt       1664
Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp Arg Thr Gly Pro Leu           
                490                 495                 500               

tca atg aca acg cag cag agt aat tct cag agc ttc tct aca tca cat       1712
Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser Phe Ser Thr Ser His           
            505                 510                 515                   

gaa ggc ttg gaa gaa gat aaa gac cat cca aca act tct act ctg aca       1760
Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr Thr Ser Thr Leu Thr           
        520                 525                 530                       

tca agc aat agg aat gat gtc aca ggt gga aga aga gac cca aat cat       1808
Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg Arg Asp Pro Asn His           
    535                 540                 545                           

tct gaa ggc tca act act tta ctg gaa ggt tat acc tct cat tac cca       1856
Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr Thr Ser His Tyr Pro           
550                 555                 560                 565           

cac acg aag gaa agc agg acc ttc atc cca gtg acc tca gct aag act       1904
His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val Thr Ser Ala Lys Thr           
                570                 575                 580               

ggg tcc ttt gga gtt act gca gtt act gtt gga gat tcc aac tct aat       1952
Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly Asp Ser Asn Ser Asn           
            585                 590                 595                   

gtc aat cgt tcc tta tca gga gac caa gac aca ttc cac ccc agt ggg       2000
Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr Phe His Pro Ser Gly           
        600                 605                 610                       

ggg tcc cat acc act cat gga tct gaa tca gat gga cac tca cat ggg       2048
Gly Ser His Thr Thr His Gly Ser Glu Ser Asp Gly His Ser His Gly           
    615                 620                 625                           

agt caa gaa ggt gga gca aac aca acc tct ggt cct ata agg aca ccc       2096
Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly Pro Ile Arg Thr Pro           
630                 635                 640                 645           

caa att cca gaa tgg ctg atc atc ttg gca tcc ctc ttg gcc ttg gct       2144
Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser Leu Leu Ala Leu Ala           
                650                 655                 660               

ttg att ctt gca gtt tgc att gca gtc aac agt cga aga agg tgt ggg       2192
Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser Arg Arg Arg Cys Gly           
            665                 670                 675                   

cag aag aaa aag cta gtg atc aac agt ggc aat gga gct gtg gag gac       2240
Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn Gly Ala Val Glu Asp           
        680                 685                 690                       

aga aag cca agt gga ctc aac gga gag gcc agc aag tct cag gaa atg       2288
Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser Lys Ser Gln Glu Met           
    695                 700                 705                           

gtg cat ttg gtg aac aag gag tcg tca gaa act cca gac cag ttt atg       2336
Val His Leu Val Asn Lys Glu Ser Ser Glu Thr Pro Asp Gln Phe Met           
710                 715                 720                 725           

aca gct gat gag aca agg aac ctg cag aat gtg gac atg aag att ggg       2384
Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val Asp Met Lys Ile Gly           
                730                 735                 740               

gtg taa cacctacacc attatcttgg aaagaaacaa ccgttggaaa cataaccatt        2440
Val                                                                       
                                                                          

acagggagct gggacactta acagatgcaa tgtgctactg attgtttcat tgcgaatctt     2500

ttttagcata aaattttcta ctctttttgt tttttgtgtt ttgttcttta aagtcaggtc     2560

caatttgtaa aaacagcatt gctttctgaa attagggccc aattaataat cagcaagaat     2620

ttgatcgttc cagttcccac ttggaggcct ttcatccctc gggtgtgcta tggatggctt     2680

ctaacaaaaa ctacacatat gtattcctga tcgccaacct ttcccccacc agctaaggac     2740

atttcccagg gttaataggg cctggtccct gggaggaaat ttgaatgggt ccattttgcc     2800

cttccatagc ctaatccctg ggcattgctt tccactgagg ttgggggttg gggtgtacta     2860

gttacacatc ttcaacagac cccctctaga aatttttcag atgcttctgg gagacaccca     2920

aagggtgaag ctatttatct gtagtaaact atttatctgt gtttttgaaa tattaaaccc     2980

tggatcagtc ctttgatcag tataattttt taaagttact ttgtcagagg cacaaaaggg     3040

tttaaactga ttcataataa atatctgtac ttcttcgatc ttc                       3083


<210>  6
<211>  742
<212>  PRT
<213>  homo sapiens

<400>  6

Met Asp Lys Phe Trp Trp His Ala Ala Trp Gly Leu Cys Leu Val Pro 
1               5                   10                  15      


Leu Ser Leu Ala Gln Ile Asp Leu Asn Ile Thr Cys Arg Phe Ala Gly 
            20                  25                  30          


Val Phe His Val Glu Lys Asn Gly Arg Tyr Ser Ile Ser Arg Thr Glu 
        35                  40                  45              


Ala Ala Asp Leu Cys Lys Ala Phe Asn Ser Thr Leu Pro Thr Met Ala 
    50                  55                  60                  


Gln Met Glu Lys Ala Leu Ser Ile Gly Phe Glu Thr Cys Arg Tyr Gly 
65                  70                  75                  80  


Phe Ile Glu Gly His Val Val Ile Pro Arg Ile His Pro Asn Ser Ile 
                85                  90                  95      


Cys Ala Ala Asn Asn Thr Gly Val Tyr Ile Leu Thr Ser Asn Thr Ser 
            100                 105                 110         


Gln Tyr Asp Thr Tyr Cys Phe Asn Ala Ser Ala Pro Pro Glu Glu Asp 
        115                 120                 125             


Cys Thr Ser Val Thr Asp Leu Pro Asn Ala Phe Asp Gly Pro Ile Thr 
    130                 135                 140                 


Ile Thr Ile Val Asn Arg Asp Gly Thr Arg Tyr Val Gln Lys Gly Glu 
145                 150                 155                 160 


Tyr Arg Thr Asn Pro Glu Asp Ile Tyr Pro Ser Asn Pro Thr Asp Asp 
                165                 170                 175     


Asp Val Ser Ser Gly Ser Ser Ser Glu Arg Ser Ser Thr Ser Gly Gly 
            180                 185                 190         


Tyr Ile Phe Tyr Thr Phe Ser Thr Val His Pro Ile Pro Asp Glu Asp 
        195                 200                 205             


Ser Pro Trp Ile Thr Asp Ser Thr Asp Arg Ile Pro Ala Thr Thr Leu 
    210                 215                 220                 


Met Ser Thr Ser Ala Thr Ala Thr Glu Thr Ala Thr Lys Arg Gln Glu 
225                 230                 235                 240 


Thr Trp Asp Trp Phe Ser Trp Leu Phe Leu Pro Ser Glu Ser Lys Asn 
                245                 250                 255     


His Leu His Thr Thr Thr Gln Met Ala Gly Thr Ser Ser Asn Thr Ile 
            260                 265                 270         


Ser Ala Gly Trp Glu Pro Asn Glu Glu Asn Glu Asp Glu Arg Asp Arg 
        275                 280                 285             


His Leu Ser Phe Ser Gly Ser Gly Ile Asp Asp Asp Glu Asp Phe Ile 
    290                 295                 300                 


Ser Ser Thr Ile Ser Thr Thr Pro Arg Ala Phe Asp His Thr Lys Gln 
305                 310                 315                 320 


Asn Gln Asp Trp Thr Gln Trp Asn Pro Ser His Ser Asn Pro Glu Val 
                325                 330                 335     


Leu Leu Gln Thr Thr Thr Arg Met Thr Asp Val Asp Arg Asn Gly Thr 
            340                 345                 350         


Thr Ala Tyr Glu Gly Asn Trp Asn Pro Glu Ala His Pro Pro Leu Ile 
        355                 360                 365             


His His Glu His His Glu Glu Glu Glu Thr Pro His Ser Thr Ser Thr 
    370                 375                 380                 


Ile Gln Ala Thr Pro Ser Ser Thr Thr Glu Glu Thr Ala Thr Gln Lys 
385                 390                 395                 400 


Glu Gln Trp Phe Gly Asn Arg Trp His Glu Gly Tyr Arg Gln Thr Pro 
                405                 410                 415     


Lys Glu Asp Ser His Ser Thr Thr Gly Thr Ala Ala Ala Ser Ala His 
            420                 425                 430         


Thr Ser His Pro Met Gln Gly Arg Thr Thr Pro Ser Pro Glu Asp Ser 
        435                 440                 445             


Ser Trp Thr Asp Phe Phe Asn Pro Ile Ser His Pro Met Gly Arg Gly 
    450                 455                 460                 


His Gln Ala Gly Arg Arg Met Asp Met Asp Ser Ser His Ser Ile Thr 
465                 470                 475                 480 


Leu Gln Pro Thr Ala Asn Pro Asn Thr Gly Leu Val Glu Asp Leu Asp 
                485                 490                 495     


Arg Thr Gly Pro Leu Ser Met Thr Thr Gln Gln Ser Asn Ser Gln Ser 
            500                 505                 510         


Phe Ser Thr Ser His Glu Gly Leu Glu Glu Asp Lys Asp His Pro Thr 
        515                 520                 525             


Thr Ser Thr Leu Thr Ser Ser Asn Arg Asn Asp Val Thr Gly Gly Arg 
    530                 535                 540                 


Arg Asp Pro Asn His Ser Glu Gly Ser Thr Thr Leu Leu Glu Gly Tyr 
545                 550                 555                 560 


Thr Ser His Tyr Pro His Thr Lys Glu Ser Arg Thr Phe Ile Pro Val 
                565                 570                 575     


Thr Ser Ala Lys Thr Gly Ser Phe Gly Val Thr Ala Val Thr Val Gly 
            580                 585                 590         


Asp Ser Asn Ser Asn Val Asn Arg Ser Leu Ser Gly Asp Gln Asp Thr 
        595                 600                 605             


Phe His Pro Ser Gly Gly Ser His Thr Thr His Gly Ser Glu Ser Asp 
    610                 615                 620                 


Gly His Ser His Gly Ser Gln Glu Gly Gly Ala Asn Thr Thr Ser Gly 
625                 630                 635                 640 


Pro Ile Arg Thr Pro Gln Ile Pro Glu Trp Leu Ile Ile Leu Ala Ser 
                645                 650                 655     


Leu Leu Ala Leu Ala Leu Ile Leu Ala Val Cys Ile Ala Val Asn Ser 
            660                 665                 670         


Arg Arg Arg Cys Gly Gln Lys Lys Lys Leu Val Ile Asn Ser Gly Asn 
        675                 680                 685             


Gly Ala Val Glu Asp Arg Lys Pro Ser Gly Leu Asn Gly Glu Ala Ser 
    690                 695                 700                 


Lys Ser Gln Glu Met Val His Leu Val Asn Lys Glu Ser Ser Glu Thr 
705                 710                 715                 720 


Pro Asp Gln Phe Met Thr Ala Asp Glu Thr Arg Asn Leu Gln Asn Val 
                725                 730                 735     


Asp Met Lys Ile Gly Val 
            740         


<210>  7
<211>  1750
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (53)..(1135)

<400>  7
cctacaggtg aaaagcccag cgacccagtc aggatttaag tttacctcaa aa atg gaa       58
                                                          Met Glu         
                                                          1               

gat ttt aac atg gag agt gac agc ttt gaa gat ttc tgg aaa ggt gaa        106
Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys Gly Glu           
        5                   10                  15                        

gat ctt agt aat tac agt tac agc tct acc ctg ccc cct ttt cta cta        154
Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe Leu Leu           
    20                  25                  30                            

gat gcc gcc cca tgt gaa cca gaa tcc ctg gaa atc aac aag tat ttt        202
Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys Tyr Phe           
35                  40                  45                  50            

gtg gtc att atc tat gcc ctg gta ttc ctg ctg agc ctg ctg gga aac        250
Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu Gly Asn           
                55                  60                  65                

tcc ctc gtg atg ctg gtc atc tta tac agc agg gtc ggc cgc tcc gtc        298
Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg Ser Val           
            70                  75                  80                    

act gat gtc tac ctg ctg aac cta gcc ttg gcc gac cta ctc ttt gcc        346
Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu Phe Ala           
        85                  90                  95                        

ctg acc ttg ccc atc tgg gcc gcc tcc aag gtg aat ggc tgg att ttt        394
Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp Ile Phe           
    100                 105                 110                           

ggc aca ttc ctg tgc aag gtg gtc tca ctc ctg aag gaa gtc aac ttc        442
Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val Asn Phe           
115                 120                 125                 130           

tat agt ggc atc ctg cta ctg gcc tgc atc agt gtg gac cgt tac ctg        490
Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg Tyr Leu           
                135                 140                 145               

gcc att gtc cat gcc aca cgc aca ctg acc cag aag cgc tac ttg gtc        538
Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr Leu Val           
            150                 155                 160                   

aaa ttc ata tgt ctc agc atc tgg ggt ctg tcc ttg ctc ctg gcc ctg        586
Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu Ala Leu           
        165                 170                 175                       

cct gtc tta ctt ttc cga agg acc gtc tac tca tcc aat gtt agc cca        634
Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val Ser Pro           
    180                 185                 190                           

gcc tgc tat gag gac atg ggc aac aat aca gca aac tgg cgg atg ctg        682
Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg Met Leu           
195                 200                 205                 210           

tta cgg atc ctg ccc cag tcc ttt ggc ttc atc gtg cca ctg ctg atc        730
Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu Leu Ile           
                215                 220                 225               

atg ctg ttc tgc tac gga ttc acc ctg cgt acg ctg ttt aag gcc cac        778
Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys Ala His           
            230                 235                 240                   

atg ggg cag aag cac cgg gcc atg cgg gtc atc ttt gct gtc gtc ctc        826
Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val Val Leu           
        245                 250                 255                       

atc ttc ctg ctt tgc tgg ctg ccc tac aac ctg gtc ctg ctg gca gac        874
Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu Ala Asp           
    260                 265                 270                           

acc ctc atg agg acc cag gtg atc cag gag acc tgt gag cgc cgc aat        922
Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg Arg Asn           
275                 280                 285                 290           

cac atc gac cgg gct ctg gat gcc acc gag att ctg ggc atc ctt cac        970
His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile Leu His           
                295                 300                 305               

agc tgc ctc aac ccc ctc atc tac gcc ttc att ggc cag aag ttt cgc       1018
Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys Phe Arg           
            310                 315                 320                   

cat gga ctc ctc aag att cta gct ata cat ggc ttg atc agc aag gac       1066
His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser Lys Asp           
        325                 330                 335                       

tcc ctg ccc aaa gac agc agg cct tcc ttt gtt ggc tct tct tca ggg       1114
Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser Ser Gly           
    340                 345                 350                           

cac act tcc act act ctc taa gacctcctgc ctaagtgcag ccccgtgggg          1165
His Thr Ser Thr Thr Leu                                                   
355                 360                                                   

ttcctccctt ctcttcacag tcacattcca agcctcatgt ccactggttc ttcttggtct     1225

cagtgtcaat gcagccccca ttgtggtcac aggaagcaga ggaggccacg ttcttactag     1285

tttcccttgc atggtttaga aagcttgccc tggtgcctca ccccttgcca taattactat     1345

gtcatttgct ggagctctgc ccatcctgcc cctgagccca tggcactcta tgttctaaga     1405

agtgaaaatc tacactccag tgagacagct ctgcatactc attaggatgg ctagtatcaa     1465

aagaaagaaa atcaggctgg ccaacgggat gaaaccctgt ctctactaaa aatacaaaaa     1525

aaaaaaaaaa aattagccgg gcgtggtggt gagtgcctgt aatcacagct acttgggagg     1585

ctgagatggg agaatcactt gaacccggga ggcagaggtt gcagtgagcc gagattgtgc     1645

ccctgcactc cagcctgagc gacagtgaga ctctgtctca gtccatgaag atgtagagga     1705

gaaactggaa ctctcgagcg ttgctggggg ggattgtaaa atggt                     1750


<210>  8
<211>  360
<212>  PRT
<213>  homo sapiens

<400>  8

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  9
<211>  324
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (1)..(324)

<400>  9
atg gcc cgc gct gct ctc tcc gcc gcc ccc agc aat ccc cgg ctc ctg         48
Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu           
1               5                   10                  15                

cga gtg gca ctg ctg ctc ctg ctc ctg gta gcc gct ggc cgg cgc gca         96
Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala           
            20                  25                  30                    

gca gga gcg tcc gtg gcc act gaa ctg cgc tgc cag tgc ttg cag acc        144
Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr           
        35                  40                  45                        

ctg cag gga att cac ccc aag aac atc caa agt gtg aac gtg aag tcc        192
Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser           
    50                  55                  60                            

ccc gga ccc cac tgc gcc caa acc gaa gtc ata gcc aca ctc aag aat        240
Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn           
65                  70                  75                  80            

ggg cgg aaa gct tgc ctc aat cct gca tcc ccc ata gtt aag aaa atc        288
Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile           
                85                  90                  95                

atc gaa aag atg ctg aac agt gac aaa tcc aac tga                        324
Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn                               
            100                 105                                       


<210>  10
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  10

Met Ala Arg Ala Ala Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Gly Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Arg Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile 
                85                  90                  95      


Ile Glu Lys Met Leu Asn Ser Asp Lys Ser Asn 
            100                 105         


<210>  11
<211>  1166
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (163)..(486)

<400>  11
gctccgggaa tttccctggc ccggccgctc cgggctttcc agtctcaacc atgcataaaa       60

agggttcgcc gatcttgggg agccacacag cccgggtcgc aggcacctcc ccgccagctc      120

tcccgcttct cgcacagctt cccgacgcgt ctgctgagcc cc atg gcc cac gcc         174
                                               Met Ala His Ala            
                                               1                          

acg ctc tcc gcc gcc ccc agc aat ccc cgg ctc ctg cgg gtg gcg ctg        222
Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu Arg Val Ala Leu           
5                   10                  15                  20            

ctg ctc ctg ctc ctg gtg gcc gcc agc cgg cgc gca gca gga gcg tcc        270
Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala Ala Gly Ala Ser           
                25                  30                  35                

gtg gtc act gaa ctg cgc tgc cag tgc ttg cag aca ctg cag gga att        318
Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr Leu Gln Gly Ile           
            40                  45                  50                    

cac ctc aag aac atc caa agt gtg aat gta agg tcc ccc gga ccc cac        366
His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser Pro Gly Pro His           
        55                  60                  65                        

tgc gcc caa acc gaa gtc ata gcc aca ctc aag aat ggg aag aaa gct        414
Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn Gly Lys Lys Ala           
    70                  75                  80                            

tgt ctc aac ccc gca tcc ccc atg gtt cag aaa atc atc gaa aag ata        462
Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile Ile Glu Lys Ile           
85                  90                  95                  100           

ctg aac aag ggg agc acc aac tga caggagagaa gtaagaagct tatcagcgta       516
Leu Asn Lys Gly Ser Thr Asn                                               
                105                                                       

tcattgacac ttcctgcagg gtggtccctg cccttaccag agctgaaaat gaaaaagaga      576

acagcagctt tctagggaca gctggaaagg acttaatgtg tttgactatt tcttacgagg      636

gttctactta tttatgtatt tatttttgaa agcttgtatt ttaatatttt acatgctgtt      696

atttaaagat gtgagtgtgt ttcatcaaac atagctcagt cctgattatt taattggaat      756

atgatgggtt ttaaatgtgt cattaaacta atatttagtg ggagaccata atgtgtcagc      816

caccttgata aatgacaggg tggggaactg gagggtgggg ggattgaaat gcaagcaatt      876

agtggatcac tgttagggta agggaatgta tgtacacatc tattttttat actttttttt      936

taaaaaaaga atgtcagttg ttatttattc aaattatctc acattatgtg ttcaacattt      996

ttatgctgaa gtttccctta gacattttat gtcttgcttg tagggcataa tgccttgttt     1056

aatgtccatt ctgcagcgtt tctctttccc ttggaaaaga gaatttatca ttactgttac     1116

atttgtacaa atgacatgat aataaaagtt ttatgaaaaa aaaaaaaaaa                1166


<210>  12
<211>  107
<212>  PRT
<213>  homo sapiens

<400>  12

Met Ala His Ala Thr Leu Ser Ala Ala Pro Ser Asn Pro Arg Leu Leu 
1               5                   10                  15      


Arg Val Ala Leu Leu Leu Leu Leu Leu Val Ala Ala Ser Arg Arg Ala 
            20                  25                  30          


Ala Gly Ala Ser Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr 
        35                  40                  45              


Leu Gln Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser 
    50                  55                  60                  


Pro Gly Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn 
65                  70                  75                  80  


Gly Lys Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile 
                85                  90                  95      


Ile Glu Lys Ile Leu Asn Lys Gly Ser Thr Asn 
            100                 105         


<210>  13
<211>  1609
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (92)..(1609)

<400>  13
ttcaagtctt tttcttttaa cggattgatc ttttgctaga tagagacaaa atatcagtgt       60

gaattacagc aaacccctat tccatgctgt t atg ggt gaa act ctg gga gat         112
                                   Met Gly Glu Thr Leu Gly Asp            
                                   1               5                      

tct cct att gac cca gaa agc gat tcc ttc act gat aca ctg tct gca        160
Ser Pro Ile Asp Pro Glu Ser Asp Ser Phe Thr Asp Thr Leu Ser Ala           
        10                  15                  20                        

aac ata tca caa gaa atg acc atg gtt gac aca gag atg cca ttc tgg        208
Asn Ile Ser Gln Glu Met Thr Met Val Asp Thr Glu Met Pro Phe Trp           
    25                  30                  35                            

ccc acc aac ttt ggg atc agc tcc gtg gat ctc tcc gta atg gaa gac        256
Pro Thr Asn Phe Gly Ile Ser Ser Val Asp Leu Ser Val Met Glu Asp           
40                  45                  50                  55            

cac tcc cac tcc ttt gat atc aag ccc ttc act act gtt gac ttc tcc        304
His Ser His Ser Phe Asp Ile Lys Pro Phe Thr Thr Val Asp Phe Ser           
                60                  65                  70                

agc att tct act cca cat tac gaa gac att cca ttc aca aga aca gat        352
Ser Ile Ser Thr Pro His Tyr Glu Asp Ile Pro Phe Thr Arg Thr Asp           
            75                  80                  85                    

cca gtg gtt gca gat tac aag tat gac ctg aaa ctt caa gag tac caa        400
Pro Val Val Ala Asp Tyr Lys Tyr Asp Leu Lys Leu Gln Glu Tyr Gln           
        90                  95                  100                       

agt gca atc aaa gtg gag cct gca tct cca cct tat tat tct gag aag        448
Ser Ala Ile Lys Val Glu Pro Ala Ser Pro Pro Tyr Tyr Ser Glu Lys           
    105                 110                 115                           

act cag ctc tac aat aag cct cat gaa gag cct tcc aac tcc ctc atg        496
Thr Gln Leu Tyr Asn Lys Pro His Glu Glu Pro Ser Asn Ser Leu Met           
120                 125                 130                 135           

gca att gaa tgt cgt gtc tgt gga gat aaa gct tct gga ttt cac tat        544
Ala Ile Glu Cys Arg Val Cys Gly Asp Lys Ala Ser Gly Phe His Tyr           
                140                 145                 150               

gga gtt cat gct tgt gaa gga tgc aag ggt ttc ttc cgg aga aca atc        592
Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg Thr Ile           
            155                 160                 165                   

aga ttg aag ctt atc tat gac aga tgt gat ctt aac tgt cgg atc cac        640
Arg Leu Lys Leu Ile Tyr Asp Arg Cys Asp Leu Asn Cys Arg Ile His           
        170                 175                 180                       

aaa aaa agt aga aat aaa tgt cag tac tgt cgg ttt cag aaa tgc ctt        688
Lys Lys Ser Arg Asn Lys Cys Gln Tyr Cys Arg Phe Gln Lys Cys Leu           
    185                 190                 195                           

gca gtg ggg atg tct cat aat gcc atc agg ttt ggg cgg atg cca cag        736
Ala Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met Pro Gln           
200                 205                 210                 215           

gcc gag aag gag aag ctg ttg gcg gag atc tcc agt gat atc gac cag        784
Ala Glu Lys Glu Lys Leu Leu Ala Glu Ile Ser Ser Asp Ile Asp Gln           
                220                 225                 230               

ctg aat cca gag tcc gct gac ctc cgg gcc ctg gca aaa cat ttg tat        832
Leu Asn Pro Glu Ser Ala Asp Leu Arg Ala Leu Ala Lys His Leu Tyr           
            235                 240                 245                   

gac tca tac ata aag tcc ttc ccg ctg acc aaa gca aag gcg agg gcg        880
Asp Ser Tyr Ile Lys Ser Phe Pro Leu Thr Lys Ala Lys Ala Arg Ala           
        250                 255                 260                       

atc ttg aca gga aag aca aca gac aaa tca cca ttc gtt atc tat gac        928
Ile Leu Thr Gly Lys Thr Thr Asp Lys Ser Pro Phe Val Ile Tyr Asp           
    265                 270                 275                           

atg aat tcc tta atg atg gga gaa gat aaa atc aag ttc aaa cac atc        976
Met Asn Ser Leu Met Met Gly Glu Asp Lys Ile Lys Phe Lys His Ile           
280                 285                 290                 295           

acc ccc ctg cag gag cag agc aaa gag gtg gcc atc cgc atc ttt cag       1024
Thr Pro Leu Gln Glu Gln Ser Lys Glu Val Ala Ile Arg Ile Phe Gln           
                300                 305                 310               

ggc tgc cag ttt cgc tcc gtg gag gct gtg cag gag atc aca gag tat       1072
Gly Cys Gln Phe Arg Ser Val Glu Ala Val Gln Glu Ile Thr Glu Tyr           
            315                 320                 325                   

gcc aaa agc att cct ggt ttt gta aat ctt gac ttg aac gac caa gta       1120
Ala Lys Ser Ile Pro Gly Phe Val Asn Leu Asp Leu Asn Asp Gln Val           
        330                 335                 340                       

act ctc ctc aaa tat gga gtc cac gag atc att tac aca atg ctg gcc       1168
Thr Leu Leu Lys Tyr Gly Val His Glu Ile Ile Tyr Thr Met Leu Ala           
    345                 350                 355                           

tcc ttg atg aat aaa gat ggg gtt ctc ata tcc gag ggc caa ggc ttc       1216
Ser Leu Met Asn Lys Asp Gly Val Leu Ile Ser Glu Gly Gln Gly Phe           
360                 365                 370                 375           

atg aca agg gag ttt cta aag agc ctg cga aag cct ttt ggt gac ttt       1264
Met Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Gly Asp Phe           
                380                 385                 390               

atg gag ccc aag ttt gag ttt gct gtg aag ttc aat gca ctg gaa tta       1312
Met Glu Pro Lys Phe Glu Phe Ala Val Lys Phe Asn Ala Leu Glu Leu           
            395                 400                 405                   

gat gac agc gac ttg gca ata ttt att gct gtc att att ctc agt gga       1360
Asp Asp Ser Asp Leu Ala Ile Phe Ile Ala Val Ile Ile Leu Ser Gly           
        410                 415                 420                       

gac cgc cca ggt ttg ctg aat gtg aag ccc att gaa gac att caa gac       1408
Asp Arg Pro Gly Leu Leu Asn Val Lys Pro Ile Glu Asp Ile Gln Asp           
    425                 430                 435                           

aac ctg cta caa gcc ctg gag ctc cag ctg aag ctg aac cac cct gag       1456
Asn Leu Leu Gln Ala Leu Glu Leu Gln Leu Lys Leu Asn His Pro Glu           
440                 445                 450                 455           

tcc tca cag ctg ttt gcc aag ctg ctc cag aaa atg aca gac ctc aga       1504
Ser Ser Gln Leu Phe Ala Lys Leu Leu Gln Lys Met Thr Asp Leu Arg           
                460                 465                 470               

cag att gtc acg gaa cac gtg cag cta ctg cag gtg atc aag aag acg       1552
Gln Ile Val Thr Glu His Val Gln Leu Leu Gln Val Ile Lys Lys Thr           
            475                 480                 485                   

gag aca gac atg agt ctt cac ccg ctc ctg cag gag atc tac aag gac       1600
Glu Thr Asp Met Ser Leu His Pro Leu Leu Gln Glu Ile Tyr Lys Asp           
        490                 495                 500                       

ttg tac tag                                                           1609
Leu Tyr                                                                   
    505                                                                   


<210>  14
<211>  505
<212>  PRT
<213>  homo sapiens

<400>  14

Met Gly Glu Thr Leu Gly Asp Ser Pro Ile Asp Pro Glu Ser Asp Ser 
1               5                   10                  15      


Phe Thr Asp Thr Leu Ser Ala Asn Ile Ser Gln Glu Met Thr Met Val 
            20                  25                  30          


Asp Thr Glu Met Pro Phe Trp Pro Thr Asn Phe Gly Ile Ser Ser Val 
        35                  40                  45              


Asp Leu Ser Val Met Glu Asp His Ser His Ser Phe Asp Ile Lys Pro 
    50                  55                  60                  


Phe Thr Thr Val Asp Phe Ser Ser Ile Ser Thr Pro His Tyr Glu Asp 
65                  70                  75                  80  


Ile Pro Phe Thr Arg Thr Asp Pro Val Val Ala Asp Tyr Lys Tyr Asp 
                85                  90                  95      


Leu Lys Leu Gln Glu Tyr Gln Ser Ala Ile Lys Val Glu Pro Ala Ser 
            100                 105                 110         


Pro Pro Tyr Tyr Ser Glu Lys Thr Gln Leu Tyr Asn Lys Pro His Glu 
        115                 120                 125             


Glu Pro Ser Asn Ser Leu Met Ala Ile Glu Cys Arg Val Cys Gly Asp 
    130                 135                 140                 


Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys 
145                 150                 155                 160 


Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Ile Tyr Asp Arg Cys 
                165                 170                 175     


Asp Leu Asn Cys Arg Ile His Lys Lys Ser Arg Asn Lys Cys Gln Tyr 
            180                 185                 190         


Cys Arg Phe Gln Lys Cys Leu Ala Val Gly Met Ser His Asn Ala Ile 
        195                 200                 205             


Arg Phe Gly Arg Met Pro Gln Ala Glu Lys Glu Lys Leu Leu Ala Glu 
    210                 215                 220                 


Ile Ser Ser Asp Ile Asp Gln Leu Asn Pro Glu Ser Ala Asp Leu Arg 
225                 230                 235                 240 


Ala Leu Ala Lys His Leu Tyr Asp Ser Tyr Ile Lys Ser Phe Pro Leu 
                245                 250                 255     


Thr Lys Ala Lys Ala Arg Ala Ile Leu Thr Gly Lys Thr Thr Asp Lys 
            260                 265                 270         


Ser Pro Phe Val Ile Tyr Asp Met Asn Ser Leu Met Met Gly Glu Asp 
        275                 280                 285             


Lys Ile Lys Phe Lys His Ile Thr Pro Leu Gln Glu Gln Ser Lys Glu 
    290                 295                 300                 


Val Ala Ile Arg Ile Phe Gln Gly Cys Gln Phe Arg Ser Val Glu Ala 
305                 310                 315                 320 


Val Gln Glu Ile Thr Glu Tyr Ala Lys Ser Ile Pro Gly Phe Val Asn 
                325                 330                 335     


Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
            340                 345                 350         


Ile Ile Tyr Thr Met Leu Ala Ser Leu Met Asn Lys Asp Gly Val Leu 
        355                 360                 365             


Ile Ser Glu Gly Gln Gly Phe Met Thr Arg Glu Phe Leu Lys Ser Leu 
    370                 375                 380                 


Arg Lys Pro Phe Gly Asp Phe Met Glu Pro Lys Phe Glu Phe Ala Val 
385                 390                 395                 400 


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Ile Phe Ile 
                405                 410                 415     


Ala Val Ile Ile Leu Ser Gly Asp Arg Pro Gly Leu Leu Asn Val Lys 
            420                 425                 430         


Pro Ile Glu Asp Ile Gln Asp Asn Leu Leu Gln Ala Leu Glu Leu Gln 
        435                 440                 445             


Leu Lys Leu Asn His Pro Glu Ser Ser Gln Leu Phe Ala Lys Leu Leu 
    450                 455                 460                 


Gln Lys Met Thr Asp Leu Arg Gln Ile Val Thr Glu His Val Gln Leu 
465                 470                 475                 480 


Leu Gln Val Ile Lys Lys Thr Glu Thr Asp Met Ser Leu His Pro Leu 
                485                 490                 495     


Leu Gln Glu Ile Tyr Lys Asp Leu Tyr 
            500                 505 


<210>  15
<211>  3734
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (310)..(1635)

<400>  15
gcggagcgtg tgacgctgcg gccgccgcgg acctggggat taatgggaaa agttttggca       60

ggagcgggag aattctgcgg agcctgcggg acggcggcgg tggcgccgta ggcagccggg      120

acagtgttgt acagtgtttt gggcatgcac gtgatactca cacagtggct tctgctcacc      180

aacagatgaa gacagatgca ccaacgaggc tgatgggaac caccctgtag aggtccatct      240

gcgttcagac ccagacgatg ccagagctat gactgggcct gcaggtgtgg cgccgagggg      300

agatcagcc atg gag cag cca cag gag gaa gcc cct gag gtc cgg gaa gag      351
          Met Glu Gln Pro Gln Glu Glu Ala Pro Glu Val Arg Glu Glu         
          1               5                   10                          

gag gag aaa gag gaa gtg gca gag gca gaa gga gcc cca gag ctc aat        399
Glu Glu Lys Glu Glu Val Ala Glu Ala Glu Gly Ala Pro Glu Leu Asn           
15                  20                  25                  30            

ggg gga cca cag cat gca ctt cct tcc agc agc tac aca gac ctc tcc        447
Gly Gly Pro Gln His Ala Leu Pro Ser Ser Ser Tyr Thr Asp Leu Ser           
                35                  40                  45                

cgg agc tcc tcg cca ccc tca ctg ctg gac caa ctg cag atg ggc tgt        495
Arg Ser Ser Ser Pro Pro Ser Leu Leu Asp Gln Leu Gln Met Gly Cys           
            50                  55                  60                    

gac ggg gcc tca tgc ggc agc ctc aac atg gag tgc cgg gtg tgc ggg        543
Asp Gly Ala Ser Cys Gly Ser Leu Asn Met Glu Cys Arg Val Cys Gly           
        65                  70                  75                        

gac aag gca tcg ggc ttc cac tac ggt gtt cat gca tgt gag ggg tgc        591
Asp Lys Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys           
    80                  85                  90                            

aag ggc ttc ttc cgt cgt acg atc cgc atg aag ctg gag tac gag aag        639
Lys Gly Phe Phe Arg Arg Thr Ile Arg Met Lys Leu Glu Tyr Glu Lys           
95                  100                 105                 110           

tgt gag cgc agc tgc aag att cag aag aag aac cgc aac aag tgc cag        687
Cys Glu Arg Ser Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln           
                115                 120                 125               

tac tgc cgc ttc cag aag tgc ctg gca ctg ggc atg tca cac aac gct        735
Tyr Cys Arg Phe Gln Lys Cys Leu Ala Leu Gly Met Ser His Asn Ala           
            130                 135                 140                   

atc cgt ttt ggt cgg atg ccg gag gct gag aag agg aag ctg gtg gca        783
Ile Arg Phe Gly Arg Met Pro Glu Ala Glu Lys Arg Lys Leu Val Ala           
        145                 150                 155                       

ggg ctg act gca aac gag ggg agc cag tac aac cca cag gtg gcc gac        831
Gly Leu Thr Ala Asn Glu Gly Ser Gln Tyr Asn Pro Gln Val Ala Asp           
    160                 165                 170                           

ctg aag gcc ttc tcc aag cac atc tac aat gcc tac ctg aaa aac ttc        879
Leu Lys Ala Phe Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe           
175                 180                 185                 190           

aac atg acc aaa aag aag gcc cgc agc atc ctc acc ggc aaa gcc agc        927
Asn Met Thr Lys Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys Ala Ser           
                195                 200                 205               

cac acg gcg ccc ttt gtg atc cac gac atc gag aca ttg tgg cag gca        975
His Thr Ala Pro Phe Val Ile His Asp Ile Glu Thr Leu Trp Gln Ala           
            210                 215                 220                   

gag aag ggg ctg gtg tgg aag cag ttg gtg aat ggc ctg cct ccc tac       1023
Glu Lys Gly Leu Val Trp Lys Gln Leu Val Asn Gly Leu Pro Pro Tyr           
        225                 230                 235                       

aag gag atc agc gtg cac gtc ttc tac cgc tgc cag tgc acc aca gtg       1071
Lys Glu Ile Ser Val His Val Phe Tyr Arg Cys Gln Cys Thr Thr Val           
    240                 245                 250                           

gag acc gtg cgg gag ctc act gag ttc gcc aag agc atc ccc agc ttc       1119
Glu Thr Val Arg Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro Ser Phe           
255                 260                 265                 270           

agc agc ctc ttc ctc aac gac cag gtt acc ctt ctc aag tat ggc gtg       1167
Ser Ser Leu Phe Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val           
                275                 280                 285               

cac gag gcc atc ttc gcc atg ctg gcc tct atc gtc aac aag gac ggg       1215
His Glu Ala Ile Phe Ala Met Leu Ala Ser Ile Val Asn Lys Asp Gly           
            290                 295                 300                   

ctg ctg gta gcc aac ggc agt ggc ttt gtc acc cgt gag ttc ctg cgc       1263
Leu Leu Val Ala Asn Gly Ser Gly Phe Val Thr Arg Glu Phe Leu Arg           
        305                 310                 315                       

agc ctc cgc aaa ccc ttc agt gat atc att gag cct aag ttt gaa ttt       1311
Ser Leu Arg Lys Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe Glu Phe           
    320                 325                 330                           

gct gtc aag ttc aac gcc ctg gaa ctt gat gac agt gac ctg gcc cta       1359
Ala Val Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Leu           
335                 340                 345                 350           

ttc att gcg gcc atc att ctg tgt gga gac cgg cca ggc ctc atg aac       1407
Phe Ile Ala Ala Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu Met Asn           
                355                 360                 365               

gtt cca cgg gtg gag gct atc cag gac acc atc ctg cgt gcc ctc gaa       1455
Val Pro Arg Val Glu Ala Ile Gln Asp Thr Ile Leu Arg Ala Leu Glu           
            370                 375                 380                   

ttc cac ctg cag gcc aac cac cct gat gcc cag tac ctc ttc ccc aag       1503
Phe His Leu Gln Ala Asn His Pro Asp Ala Gln Tyr Leu Phe Pro Lys           
        385                 390                 395                       

ctg ctg cag aag atg gct gac ctg cgg caa ctg gtc acc gag cac gcc       1551
Leu Leu Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala           
    400                 405                 410                           

cag atg atg cag cgg atc aag aag acc gaa acc gag acc tcg ctg cac       1599
Gln Met Met Gln Arg Ile Lys Lys Thr Glu Thr Glu Thr Ser Leu His           
415                 420                 425                 430           

cct ctg ctc cag gag atc tac aag gac atg tac taa cggcggcacc            1645
Pro Leu Leu Gln Glu Ile Tyr Lys Asp Met Tyr                               
                435                 440                                   

caggcctccc tgcagactcc aatggggcca gcactggagg ggcccaccca catgactttt     1705

ccattgacca gcccttgagc acccggcctg gagcagcaga gtcccacgat cgccctcaga     1765

cacatgacac ccacggcctc tggctccctg tgccctctct cccgcttcct ccagccagct     1825

ctcttcctgt ctttgttgtc tccctctttc tcagttcctc tttcttttct aattcctgtt     1885

gctctgtttc ttcctttctg taggtttctc tcttcccttc tcccttgccc tccctttctc     1945

tctccacccc ccacgtctgt cctcctttct tattctgtga gatgttttgt attatttcac     2005

cagcagcata gaacaggacc tctgcttttg cacacctttt ccccaggagc agaagagagt     2065

ggggcctgcc ctctgcccca tcattgcacc tgcaggctta ggtcctcact tctgtctcct     2125

gtcttcagag caaaagactt gagccatcca aagaaacact aagctctctg ggcctgggtt     2185

ccagggaagg ctaagcatgg cctggactga ctgcagcccc ctatagtcat ggggtccctg     2245

ctgcaaagga cagtgggcag gaggccccag gctgagagcc agatgcctcc ccaagactgt     2305

cattgcccct ccgatgctga ggccacccac tgacccaact gatcctgctc cagcagcaca     2365

cctcagcccc actgacaccc agtgtccttc catcttcaca ctggtttgcc aggccaatgt     2425

tgctgatggc cccctgcact ggccgctgga cggcactctc ccagcttgga agtaggcagg     2485

gttccctcca ggtgggcccc cacctcactg aagaggagca agtctcaaga gaaggagggg     2545

ggattggtgg ttggaggaag cagcacaccc aattctgccc ctaggactcg gggtctgagt     2605

cctggggtca ggccagggag agctcggggc aggccttccg ccagcactcc cactgccccc     2665

ctgcccagta gcagccgccc acattgtgtc agcatccagg gccagggcct ggcctcacat     2725

ccccctgctc ctttctctag ctggctccac gggagttcag gccccactcc ccctgaagct     2785

gcccctccag cacacacaca taagcactga aatcacttta cctgcaggct ccatgcacct     2845

cccttccctc cctgaggcag gtgagaaccc agagagaggg gcctgcaggt gagcaggcag     2905

ggctgggcca ggtctccggg gaggcagggg tcctgcaggt cctggtgggt cagcccagca     2965

cctgctccca gtgggagctt cccgggataa actgagcctg ttcattctga tgtccatttg     3025

tcccaatagc tctactgccc tccccttccc ctttactcag cccagctggc cacctagaag     3085

tctccctgca cagcctctag tgtccgggga ccttgtggga ccagtcccac accgctggtc     3145

cctgccctcc cctgctccca ggttgaggtg cgctcacctc agagcagggc caaagcacag     3205

ctgggcatgc catgtctgag cggcgcagag ccctccaggc ctgcaggggc aaggggctgg     3265

ctggagtctc agagcacaga ggtaggagaa ctggggttca agcccaggct tcctgggtcc     3325

tgcctggtcc tccctcccaa ggagccattc tgtgtgtgac tctgggtgga agtgcccagc     3385

ccctgcccct acgggcgctg cagcctccct tccatgcccc aggatcactc tctgctggca     3445

ggattcttcc cgctccccac ctacccagct gatgggggtt ggggtgcttc ctttcaggcc     3505

aaggctatga agggacagct gctgggaccc acctccccct ccccggccac atgccgcgtc     3565

cctgccccga cccgggtctg gtgctgagga tacagctctt ctcagtgtct gaacaatctc     3625

caaaattgaa atgtatattt ttgctaggag ccccagcttc ctgtgttttt aatataaata     3685

gtgtacacag actgacgaaa ctttaaataa atgggaatta aatatttaa                 3734


<210>  16
<211>  441
<212>  PRT
<213>  homo sapiens

<400>  16

Met Glu Gln Pro Gln Glu Glu Ala Pro Glu Val Arg Glu Glu Glu Glu 
1               5                   10                  15      


Lys Glu Glu Val Ala Glu Ala Glu Gly Ala Pro Glu Leu Asn Gly Gly 
            20                  25                  30          


Pro Gln His Ala Leu Pro Ser Ser Ser Tyr Thr Asp Leu Ser Arg Ser 
        35                  40                  45              


Ser Ser Pro Pro Ser Leu Leu Asp Gln Leu Gln Met Gly Cys Asp Gly 
    50                  55                  60                  


Ala Ser Cys Gly Ser Leu Asn Met Glu Cys Arg Val Cys Gly Asp Lys 
65                  70                  75                  80  


Ala Ser Gly Phe His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly 
                85                  90                  95      


Phe Phe Arg Arg Thr Ile Arg Met Lys Leu Glu Tyr Glu Lys Cys Glu 
            100                 105                 110         


Arg Ser Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys 
        115                 120                 125             


Arg Phe Gln Lys Cys Leu Ala Leu Gly Met Ser His Asn Ala Ile Arg 
    130                 135                 140                 


Phe Gly Arg Met Pro Glu Ala Glu Lys Arg Lys Leu Val Ala Gly Leu 
145                 150                 155                 160 


Thr Ala Asn Glu Gly Ser Gln Tyr Asn Pro Gln Val Ala Asp Leu Lys 
                165                 170                 175     


Ala Phe Ser Lys His Ile Tyr Asn Ala Tyr Leu Lys Asn Phe Asn Met 
            180                 185                 190         


Thr Lys Lys Lys Ala Arg Ser Ile Leu Thr Gly Lys Ala Ser His Thr 
        195                 200                 205             


Ala Pro Phe Val Ile His Asp Ile Glu Thr Leu Trp Gln Ala Glu Lys 
    210                 215                 220                 


Gly Leu Val Trp Lys Gln Leu Val Asn Gly Leu Pro Pro Tyr Lys Glu 
225                 230                 235                 240 


Ile Ser Val His Val Phe Tyr Arg Cys Gln Cys Thr Thr Val Glu Thr 
                245                 250                 255     


Val Arg Glu Leu Thr Glu Phe Ala Lys Ser Ile Pro Ser Phe Ser Ser 
            260                 265                 270         


Leu Phe Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val His Glu 
        275                 280                 285             


Ala Ile Phe Ala Met Leu Ala Ser Ile Val Asn Lys Asp Gly Leu Leu 
    290                 295                 300                 


Val Ala Asn Gly Ser Gly Phe Val Thr Arg Glu Phe Leu Arg Ser Leu 
305                 310                 315                 320 


Arg Lys Pro Phe Ser Asp Ile Ile Glu Pro Lys Phe Glu Phe Ala Val 
                325                 330                 335     


Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Leu Ala Leu Phe Ile 
            340                 345                 350         


Ala Ala Ile Ile Leu Cys Gly Asp Arg Pro Gly Leu Met Asn Val Pro 
        355                 360                 365             


Arg Val Glu Ala Ile Gln Asp Thr Ile Leu Arg Ala Leu Glu Phe His 
    370                 375                 380                 


Leu Gln Ala Asn His Pro Asp Ala Gln Tyr Leu Phe Pro Lys Leu Leu 
385                 390                 395                 400 


Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala Gln Met 
                405                 410                 415     


Met Gln Arg Ile Lys Lys Thr Glu Thr Glu Thr Ser Leu His Pro Leu 
            420                 425                 430         


Leu Gln Glu Ile Tyr Lys Asp Met Tyr 
        435                 440     


<210>  17
<211>  2121
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (559)..(1878)

<400>  17
ctgctcgcgg ccgccaccgc cgggccccgg ccgtccctgg ctcccctcct gcctcgagaa       60

gggcagggct tctcagaggc ttggcgggaa aaaagaacgg agggagggat cgcgctgagt      120

ataaaagccg gttttcgggg ctttatctaa ctcgctgtag taattccagc gagaggcaga      180

gggagcgagc gggcggccgg ctagggtgga agagccgggc gagcagagct gcgctgcggg      240

cgtcctggga agggagatcc ggagcgaata gggggcttcg cctctggccc agccctcccg      300

cttgatcccc caggccagcg gtccgcaacc cttgccgcat ccacgaaact ttgcccatag      360

cagcgggcgg gcactttgca ctggaactta caacacccga gcaaggacgc gactctcccg      420

acgcggggag gctattctgc ccatttgggg acacttcccc gccgctgcca ggacccgctt      480

ctctgaaagg ctctccttgc agctgcttag acgctggatt tttttcgggt agtggaaaac      540

cagcagcctc ccgcgacg atg ccc ctc aac gtt agc ttc acc aac agg aac        591
                    Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn           
                    1               5                   10                

tat gac ctc gac tac gac tcg gtg cag ccg tat ttc tac tgc gac gag        639
Tyr Asp Leu Asp Tyr Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu           
            15                  20                  25                    

gag gag aac ttc tac cag cag cag cag cag agc gag ctg cag ccc ccg        687
Glu Glu Asn Phe Tyr Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro           
        30                  35                  40                        

gcg ccc agc gag gat atc tgg aag aaa ttc gag ctg ctg ccc acc ccg        735
Ala Pro Ser Glu Asp Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro           
    45                  50                  55                            

ccc ctg tcc cct agc cgc cgc tcc ggg ctc tgc tcg ccc tcc tac gtt        783
Pro Leu Ser Pro Ser Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val           
60                  65                  70                  75            

gcg gtc aca ccc ttc tcc ctt cgg gga gac aac gac ggc ggt ggc ggg        831
Ala Val Thr Pro Phe Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly           
                80                  85                  90                

agc ttc tcc acg gcc gac cag ctg gag atg gtg acc gag ctg ctg gga        879
Ser Phe Ser Thr Ala Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly           
            95                  100                 105                   

gga gac atg gtg aac cag agt ttc atc tgc gac ccg gac gac gag acc        927
Gly Asp Met Val Asn Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr           
        110                 115                 120                       

ttc atc aaa aac atc atc atc cag gac tgt atg tgg agc ggc ttc tcg        975
Phe Ile Lys Asn Ile Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser           
    125                 130                 135                           

gcc gcc gcc aag ctc gtc tca gag aag ctg gcc tcc tac cag gct gcg       1023
Ala Ala Ala Lys Leu Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala           
140                 145                 150                 155           

cgc aaa gac agc ggc agc ccg aac ccc gcc cgc ggc cac agc gtc tgc       1071
Arg Lys Asp Ser Gly Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys           
                160                 165                 170               

tcc acc tcc agc ttg tac ctg cag gat ctg agc gcc gcc gcc tca gag       1119
Ser Thr Ser Ser Leu Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu           
            175                 180                 185                   

tgc atc gac ccc tcg gtg gtc ttc ccc tac cct ctc aac gac agc agc       1167
Cys Ile Asp Pro Ser Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser           
        190                 195                 200                       

tcg ccc aag tcc tgc gcc tcg caa gac tcc agc gcc ttc tct ccg tcc       1215
Ser Pro Lys Ser Cys Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser           
    205                 210                 215                           

tcg gat tct ctg ctc tcc tcg acg gag tcc tcc ccg cag ggc agc ccc       1263
Ser Asp Ser Leu Leu Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro           
220                 225                 230                 235           

gag ccc ctg gtg ctc cat gag gag aca ccg ccc acc acc agc agc gac       1311
Glu Pro Leu Val Leu His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp           
                240                 245                 250               

tct gag gag gaa caa gaa gat gag gaa gaa atc gat gtt gtt tct gtg       1359
Ser Glu Glu Glu Gln Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val           
            255                 260                 265                   

gaa aag agg cag gct cct ggc aaa agg tca gag tct gga tca cct tct       1407
Glu Lys Arg Gln Ala Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser           
        270                 275                 280                       

gct gga ggc cac agc aaa cct cct cac agc cca ctg gtc ctc aag agg       1455
Ala Gly Gly His Ser Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg           
    285                 290                 295                           

tgc cac gtc tcc aca cat cag cac aac tac gca gcg cct ccc tcc act       1503
Cys His Val Ser Thr His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr           
300                 305                 310                 315           

cgg aag gac tat cct gct gcc aag agg gtc aag ttg gac agt gtc aga       1551
Arg Lys Asp Tyr Pro Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg           
                320                 325                 330               

gtc ctg aga cag atc agc aac aac cga aaa tgc acc agc ccc agg tcc       1599
Val Leu Arg Gln Ile Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser           
            335                 340                 345                   

tcg gac acc gag gag aat gtc aag agg cga aca cac aac gtc ttg gag       1647
Ser Asp Thr Glu Glu Asn Val Lys Arg Arg Thr His Asn Val Leu Glu           
        350                 355                 360                       

cgc cag agg agg aac gag cta aaa cgg agc ttt ttt gcc ctg cgt gac       1695
Arg Gln Arg Arg Asn Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp           
    365                 370                 375                           

cag atc ccg gag ttg gaa aac aat gaa aag gcc ccc aag gta gtt atc       1743
Gln Ile Pro Glu Leu Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile           
380                 385                 390                 395           

ctt aaa aaa gcc aca gca tac atc ctg tcc gtc caa gca gag gag caa       1791
Leu Lys Lys Ala Thr Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln           
                400                 405                 410               

aag ctc att tct gaa gag gac ttg ttg cgg aaa cga cga gaa cag ttg       1839
Lys Leu Ile Ser Glu Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu           
            415                 420                 425                   

aaa cac aaa ctt gaa cag cta cgg aac tct tgt gcg taa ggaaaagtaa        1888
Lys His Lys Leu Glu Gln Leu Arg Asn Ser Cys Ala                           
        430                 435                                           

ggaaaacgat tccttctaac agaaatgtcc tgagcaatca cctatgaact tgtttcaaat     1948

gcatgatcaa atgcaacctc acaaccttgg ctgagtcttg agactgaaag atttagccat     2008

aatgtaaact gcctcaaatt ggactttggg cataaaagaa cttttttatg cttaccatct     2068

tttttttttc tttaacagat ttgtatttaa gaattgtttt taaaaaattt taa            2121


<210>  18
<211>  439
<212>  PRT
<213>  homo sapiens

<400>  18

Met Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr 
1               5                   10                  15      


Asp Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr 
            20                  25                  30          


Gln Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp 
        35                  40                  45              


Ile Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser 
    50                  55                  60                  


Arg Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe 
65                  70                  75                  80  


Ser Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala 
                85                  90                  95      


Asp Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn 
            100                 105                 110         


Gln Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile 
        115                 120                 125             


Ile Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu 
    130                 135                 140                 


Val Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly 
145                 150                 155                 160 


Ser Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu 
                165                 170                 175     


Tyr Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser 
            180                 185                 190         


Val Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys 
        195                 200                 205             


Ala Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu 
    210                 215                 220                 


Ser Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu 
225                 230                 235                 240 


His Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln 
                245                 250                 255     


Glu Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala 
            260                 265                 270         


Pro Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser 
        275                 280                 285             


Lys Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr 
    290                 295                 300                 


His Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro 
305                 310                 315                 320 


Ala Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile 
                325                 330                 335     


Ser Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu 
            340                 345                 350         


Asn Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn 
        355                 360                 365             


Glu Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu 
    370                 375                 380                 


Glu Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr 
385                 390                 395                 400 


Ala Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu 
                405                 410                 415     


Glu Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu 
            420                 425                 430         


Gln Leu Arg Asn Ser Cys Ala 
        435                 


<210>  19
<211>  1641
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (166)..(1110)

<400>  19
ctccctgtgt tggtggagga tgtctgcagc agcatttaaa ttctgggagg gcttggttgt       60

cagcagcagc aggaggaggc agagcacagc atcgtcggga ccagactcgt ctcaggccag      120

ttgcagcctt ctcagccaaa cgccgaccaa ggaaaactca ctacc atg aga att gca      177
                                                  Met Arg Ile Ala         
                                                  1                       

gtg att tgc ttt tgc ctc cta ggc atc acc tgt gcc ata cca gtt aaa        225
Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala Ile Pro Val Lys           
5                   10                  15                  20            

cag gct gat tct gga agt tct gag gaa aag cag ctt tac aac aaa tac        273
Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu Tyr Asn Lys Tyr           
                25                  30                  35                

cca gat gct gtg gcc aca tgg cta aac cct gac cca tct cag aag cag        321
Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro Ser Gln Lys Gln           
            40                  45                  50                    

aat ctc cta gcc cca cag aat gct gtg tcc tct gaa gaa acc aat gac        369
Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu Thr Asn Asp           
        55                  60                  65                        

ttt aaa caa gag acc ctt cca agt aag tcc aac gaa agc cat gac cac        417
Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu Ser His Asp His           
    70                  75                  80                            

atg gat gat atg gat gat gaa gat gat gat gac cat gtg gac agc cag        465
Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His Val Asp Ser Gln           
85                  90                  95                  100           

gac tcc att gac tcg aac gac tct gat gat gta gat gac act gat gat        513
Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp Asp Thr Asp Asp           
                105                 110                 115               

tct cac cag tct gat gag tct cac cat tct gat gaa tct gat gaa ctg        561
Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu Ser Asp Glu Leu           
            120                 125                 130                   

gtc act gat ttt ccc acg gac ctg cca gca acc gaa gtt ttc act cca        609
Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu Val Phe Thr Pro           
        135                 140                 145                       

gtt gtc ccc aca gta gac aca tat gat ggc cga ggt gat agt gtg gtt        657
Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly Asp Ser Val Val           
    150                 155                 160                           

tat gga ctg agg tca aaa tct aag aag ttt cgc aga cct gac atc cag        705
Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg Pro Asp Ile Gln           
165                 170                 175                 180           

tac cct gat gct aca gac gag gac atc acc tca cac atg gaa agc gag        753
Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His Met Glu Ser Glu           
                185                 190                 195               

gag ttg aat ggt gca tac aag gcc atc ccc gtt gcc cag gac ctg aac        801
Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala Gln Asp Leu Asn           
            200                 205                 210                   

gcg cct tct gat tgg gac agc cgt ggg aag gac agt tat gaa acg agt        849
Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser Tyr Glu Thr Ser           
        215                 220                 225                       

cag ctg gat gac cag agt gct gaa acc cac agc cac aag cag tcc aga        897
Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His Lys Gln Ser Arg           
    230                 235                 240                           

tta tat aag cgg aaa gcc aat gat gag agc aat gag cat tcc gat gtg        945
Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu His Ser Asp Val           
245                 250                 255                 260           

att gat agt cag gaa ctt tcc aaa gtc agc cgt gaa ttc cac agc cat        993
Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu Phe His Ser His           
                265                 270                 275               

gaa ttt cac agc cat gaa gat atg ctg gtt gta gac ccc aaa agt aag       1041
Glu Phe His Ser His Glu Asp Met Leu Val Val Asp Pro Lys Ser Lys           
            280                 285                 290                   

gaa gaa gat aaa cac ctg aaa ttt cgt att tct cat gaa tta gat agt       1089
Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His Glu Leu Asp Ser           
        295                 300                 305                       

gca tct tct gag gtc aat taa aaggagaaaa aatacaattt ctcactttgc          1140
Ala Ser Ser Glu Val Asn                                                   
    310                                                                   

atttagtcaa aagaaaaaat gctttatagc aaaatgaaag agaacatgaa atgcttcttt     1200

ctcagtttat tggttgaatg tgtatctatt tgagtctgga aataactaat gtgtttgata     1260

attagtttag tttgtggctt catggaaact ccctgtaaac taaaagcttc agggttatgt     1320

ctatgttcat tctatagaag aaatgcaaac tatcactgta ttttaatatt tgttattctc     1380

tcatgaatag aaatttatgt agaagcaaac aaaatacttt tacccactta aaaagagaat     1440

ataacatttt atgtcactat aatcttttgt tttttaagtt agtgtatatt ttgttgtgat     1500

tatctttttg tggtgtgaat aaatctttta tcttgaatgt aataagaatt tggtggtgtc     1560

aattgcttat ttgttttccc acggttgtcc agcaattaat aaaacataac cttttttact     1620

gcctaaaaaa aaaaaaaaaa a                                               1641


<210>  20
<211>  314
<212>  PRT
<213>  homo sapiens

<400>  20

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu 
    50                  55                  60                  


Glu Thr Asn Asp Phe Lys Gln Glu Thr Leu Pro Ser Lys Ser Asn Glu 
65                  70                  75                  80  


Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp Asp His 
                85                  90                  95      


Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp Val Asp 
            100                 105                 110         


Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser Asp Glu 
        115                 120                 125             


Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala Thr Glu 
    130                 135                 140                 


Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly Arg Gly 
145                 150                 155                 160 


Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe Arg Arg 
                165                 170                 175     


Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr Ser His 
            180                 185                 190         


Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro Val Ala 
        195                 200                 205             


Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys Asp Ser 
    210                 215                 220                 


Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His Ser His 
225                 230                 235                 240 


Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser Asn Glu 
                245                 250                 255     


His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser Arg Glu 
            260                 265                 270         


Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val Val Asp 
        275                 280                 285             


Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile Ser His 
    290                 295                 300                 


Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
305                 310                 


<210>  21
<211>  2539
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (321)..(1793)

<400>  21
ggagtctctt gctctggttc ttgctgttcc tgctcctgct cccgccgctc cccgtcctgc       60

tcgcggaccc aggggcgccc acgccagtga atccctgttg ttactatcca tgccagcacc      120

agggcatctg tgtccgcttc ggccttgacc gctaccagtg tgactgcacc cgcacgggct      180

attccggccc caactgcacc atccctggcc tgtggacctg gctccggaat tcactgcggc      240

ccagcccctc tttcacccac ttcctgctca ctcacgggcg ctggttctgg gagtttgtca      300

atgccacctt catccgagag atg ctc atg cgc ctg gta ctc aca gtg cgc tcc      353
                      Met Leu Met Arg Leu Val Leu Thr Val Arg Ser         
                      1               5                   10              

aac ctt atc ccc agt ccc ccc acc tac aac tca gca cat gac tac atc        401
Asn Leu Ile Pro Ser Pro Pro Thr Tyr Asn Ser Ala His Asp Tyr Ile           
            15                  20                  25                    

agc tgg gag tct ttc tcc aac gtg agc tat tac act cgt att ctg ccc        449
Ser Trp Glu Ser Phe Ser Asn Val Ser Tyr Tyr Thr Arg Ile Leu Pro           
        30                  35                  40                        

tct gtg cct aaa gat tgc ccc aca ccc atg gga acc aaa ggg aag aag        497
Ser Val Pro Lys Asp Cys Pro Thr Pro Met Gly Thr Lys Gly Lys Lys           
    45                  50                  55                            

cag ttg cca gat gcc cag ctc ctg gcc cgc cgc ttc ctg ctc agg agg        545
Gln Leu Pro Asp Ala Gln Leu Leu Ala Arg Arg Phe Leu Leu Arg Arg           
60                  65                  70                  75            

aag ttc ata cct gac ccc caa ggc acc aac ctc atg ttt gcc ttc ttt        593
Lys Phe Ile Pro Asp Pro Gln Gly Thr Asn Leu Met Phe Ala Phe Phe           
                80                  85                  90                

gca caa cac ttc acc cac cag ttc ttc aaa act tct ggc aag atg ggt        641
Ala Gln His Phe Thr His Gln Phe Phe Lys Thr Ser Gly Lys Met Gly           
            95                  100                 105                   

cct ggc ttc acc aag gcc ttg ggc cat ggg gta gac ctc ggc cac att        689
Pro Gly Phe Thr Lys Ala Leu Gly His Gly Val Asp Leu Gly His Ile           
        110                 115                 120                       

tat gga gac aat ctg gag cgt cag tat caa ctg cgg ctc ttt aag gat        737
Tyr Gly Asp Asn Leu Glu Arg Gln Tyr Gln Leu Arg Leu Phe Lys Asp           
    125                 130                 135                           

ggg aaa ctc aag tac cag gtg ctg gat gga gaa atg tac ccg ccc tcg        785
Gly Lys Leu Lys Tyr Gln Val Leu Asp Gly Glu Met Tyr Pro Pro Ser           
140                 145                 150                 155           

gta gaa gag gcg cct gtg ttg atg cac tac ccc cga ggc atc ccg ccc        833
Val Glu Glu Ala Pro Val Leu Met His Tyr Pro Arg Gly Ile Pro Pro           
                160                 165                 170               

cag agc cag atg gct gtg ggc cag gag gtg ttt ggg ctg ctt cct ggg        881
Gln Ser Gln Met Ala Val Gly Gln Glu Val Phe Gly Leu Leu Pro Gly           
            175                 180                 185                   

ctc atg ctg tat gcc acg ctc tgg cta cgt gag cac aac cgt gtg tgt        929
Leu Met Leu Tyr Ala Thr Leu Trp Leu Arg Glu His Asn Arg Val Cys           
        190                 195                 200                       

gac ctg ctg aag gct gag cac ccc acc tgg ggc gat gag cag ctt ttc        977
Asp Leu Leu Lys Ala Glu His Pro Thr Trp Gly Asp Glu Gln Leu Phe           
    205                 210                 215                           

cag acg acc cgc ctc atc ctc ata ggg gag acc atc aag att gtc atc       1025
Gln Thr Thr Arg Leu Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile           
220                 225                 230                 235           

gag gag tac gtg cag cag ctg agt ggc tat ttc ctg cag ctg aaa ttt       1073
Glu Glu Tyr Val Gln Gln Leu Ser Gly Tyr Phe Leu Gln Leu Lys Phe           
                240                 245                 250               

gac cca gag ctg ctg ttc ggt gtc cag ttc caa tac cgc aac cgc att       1121
Asp Pro Glu Leu Leu Phe Gly Val Gln Phe Gln Tyr Arg Asn Arg Ile           
            255                 260                 265                   

gcc atg gag ttc aac cat ctc tac cac tgg cac ccc ctc atg cct gac       1169
Ala Met Glu Phe Asn His Leu Tyr His Trp His Pro Leu Met Pro Asp           
        270                 275                 280                       

tcc ttc aag gtg ggc tcc cag gag tac agc tac gag cag ttc ttg ttc       1217
Ser Phe Lys Val Gly Ser Gln Glu Tyr Ser Tyr Glu Gln Phe Leu Phe           
    285                 290                 295                           

aac acc tcc atg ttg gtg gac tat ggg gtt gag gcc ctg gtg gat gcc       1265
Asn Thr Ser Met Leu Val Asp Tyr Gly Val Glu Ala Leu Val Asp Ala           
300                 305                 310                 315           

ttc tct cgc cag att gct ggc cgg atc ggt ggg ggc agg aac atg gac       1313
Phe Ser Arg Gln Ile Ala Gly Arg Ile Gly Gly Gly Arg Asn Met Asp           
                320                 325                 330               

cac cac atc ctg cat gtg gct gtg gat gtc atc agg gag tct cgg gag       1361
His His Ile Leu His Val Ala Val Asp Val Ile Arg Glu Ser Arg Glu           
            335                 340                 345                   

atg cgg ctg cag ccc ttc aat gag tac cgc aag agg ttt ggc atg aaa       1409
Met Arg Leu Gln Pro Phe Asn Glu Tyr Arg Lys Arg Phe Gly Met Lys           
        350                 355                 360                       

ccc tac acc tcc ttc cag gag ctc gta gga gag aag gag atg gca gca       1457
Pro Tyr Thr Ser Phe Gln Glu Leu Val Gly Glu Lys Glu Met Ala Ala           
    365                 370                 375                           

gag ttg gag gaa ttg tat gga gac att gat gcg ttg gag ttc tac cct       1505
Glu Leu Glu Glu Leu Tyr Gly Asp Ile Asp Ala Leu Glu Phe Tyr Pro           
380                 385                 390                 395           

gga ctg ctt ctt gaa aag tgc cat cca aac tct atc ttt ggg gag agt       1553
Gly Leu Leu Leu Glu Lys Cys His Pro Asn Ser Ile Phe Gly Glu Ser           
                400                 405                 410               

atg ata gag att ggg gct ccc ttt tcc ctc aag ggt ctc cta ggg aat       1601
Met Ile Glu Ile Gly Ala Pro Phe Ser Leu Lys Gly Leu Leu Gly Asn           
            415                 420                 425                   

ccc atc tgt tct ccg gag tac tgg aag ccg agc aca ttt ggc ggc gag       1649
Pro Ile Cys Ser Pro Glu Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu           
        430                 435                 440                       

gtg ggc ttt aac att gtc aag acg gcc aca ctg aag aag ctg gtc tgc       1697
Val Gly Phe Asn Ile Val Lys Thr Ala Thr Leu Lys Lys Leu Val Cys           
    445                 450                 455                           

ctc aac acc aag acc tgt ccc tac gtt tcc ttc cgt gtg ccg gat gcc       1745
Leu Asn Thr Lys Thr Cys Pro Tyr Val Ser Phe Arg Val Pro Asp Ala           
460                 465                 470                 475           

agt cag gat gat ggg cct gct gtg gag cga cca tcc aca gag ctc tga       1793
Ser Gln Asp Asp Gly Pro Ala Val Glu Arg Pro Ser Thr Glu Leu               
                480                 485                 490               

ggggcaggaa agcagcattc tggaggggag agctttgtgc ttgtcattcc agagtgctga     1853

ggccagggct gatggtctta aatgctcatt ttctggtttg gcatggtgag tgttggggtt     1913

gacatttaga actttaagtc tcacccatta tctggaatat tgtgattctg tttattcttc     1973

cagaatgctg aactccttgt tagcccttca gattgttagg agtggttctc atttggtctg     2033

ccagaatact gggttcttag ttgacaacct agaatgtcag atttctggtt gatttgtaac     2093

acagtcattc taggatgtgg agctactgat gaaatctgct agaaagttag ggggttctta     2153

ttttgcattc cagaatcttg actttctgat tggtgattca aagtgttgtg ttcctggctg     2213

atgatccaga acagtggctc gtatcccaaa tctgtcagca tctggctgtc tagaatgtgg     2273

atttgattca ttttcctgtt cagtgagata tcatagagac ggagatccta aggtccaaca     2333

agaatgcatt ccctgaatct gtgcctgcac tgagagggca aggaagtggg gtgttcttct     2393

tgggaccccc actaagaccc tggtctgagg atgtagagag aacaggtggg ctgtattcac     2453

gccattggtt ggaagctacc agagctctat ccccatccag gtcttgactc atggcagctg     2513

tttctcatga agctaataaa attcgc                                          2539


<210>  22
<211>  490
<212>  PRT
<213>  homo sapiens

<400>  22

Met Leu Met Arg Leu Val Leu Thr Val Arg Ser Asn Leu Ile Pro Ser 
1               5                   10                  15      


Pro Pro Thr Tyr Asn Ser Ala His Asp Tyr Ile Ser Trp Glu Ser Phe 
            20                  25                  30          


Ser Asn Val Ser Tyr Tyr Thr Arg Ile Leu Pro Ser Val Pro Lys Asp 
        35                  40                  45              


Cys Pro Thr Pro Met Gly Thr Lys Gly Lys Lys Gln Leu Pro Asp Ala 
    50                  55                  60                  


Gln Leu Leu Ala Arg Arg Phe Leu Leu Arg Arg Lys Phe Ile Pro Asp 
65                  70                  75                  80  


Pro Gln Gly Thr Asn Leu Met Phe Ala Phe Phe Ala Gln His Phe Thr 
                85                  90                  95      


His Gln Phe Phe Lys Thr Ser Gly Lys Met Gly Pro Gly Phe Thr Lys 
            100                 105                 110         


Ala Leu Gly His Gly Val Asp Leu Gly His Ile Tyr Gly Asp Asn Leu 
        115                 120                 125             


Glu Arg Gln Tyr Gln Leu Arg Leu Phe Lys Asp Gly Lys Leu Lys Tyr 
    130                 135                 140                 


Gln Val Leu Asp Gly Glu Met Tyr Pro Pro Ser Val Glu Glu Ala Pro 
145                 150                 155                 160 


Val Leu Met His Tyr Pro Arg Gly Ile Pro Pro Gln Ser Gln Met Ala 
                165                 170                 175     


Val Gly Gln Glu Val Phe Gly Leu Leu Pro Gly Leu Met Leu Tyr Ala 
            180                 185                 190         


Thr Leu Trp Leu Arg Glu His Asn Arg Val Cys Asp Leu Leu Lys Ala 
        195                 200                 205             


Glu His Pro Thr Trp Gly Asp Glu Gln Leu Phe Gln Thr Thr Arg Leu 
    210                 215                 220                 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Glu Tyr Val Gln 
225                 230                 235                 240 


Gln Leu Ser Gly Tyr Phe Leu Gln Leu Lys Phe Asp Pro Glu Leu Leu 
                245                 250                 255     


Phe Gly Val Gln Phe Gln Tyr Arg Asn Arg Ile Ala Met Glu Phe Asn 
            260                 265                 270         


His Leu Tyr His Trp His Pro Leu Met Pro Asp Ser Phe Lys Val Gly 
        275                 280                 285             


Ser Gln Glu Tyr Ser Tyr Glu Gln Phe Leu Phe Asn Thr Ser Met Leu 
    290                 295                 300                 


Val Asp Tyr Gly Val Glu Ala Leu Val Asp Ala Phe Ser Arg Gln Ile 
305                 310                 315                 320 


Ala Gly Arg Ile Gly Gly Gly Arg Asn Met Asp His His Ile Leu His 
                325                 330                 335     


Val Ala Val Asp Val Ile Arg Glu Ser Arg Glu Met Arg Leu Gln Pro 
            340                 345                 350         


Phe Asn Glu Tyr Arg Lys Arg Phe Gly Met Lys Pro Tyr Thr Ser Phe 
        355                 360                 365             


Gln Glu Leu Val Gly Glu Lys Glu Met Ala Ala Glu Leu Glu Glu Leu 
    370                 375                 380                 


Tyr Gly Asp Ile Asp Ala Leu Glu Phe Tyr Pro Gly Leu Leu Leu Glu 
385                 390                 395                 400 


Lys Cys His Pro Asn Ser Ile Phe Gly Glu Ser Met Ile Glu Ile Gly 
                405                 410                 415     


Ala Pro Phe Ser Leu Lys Gly Leu Leu Gly Asn Pro Ile Cys Ser Pro 
            420                 425                 430         


Glu Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Asn Ile 
        435                 440                 445             


Val Lys Thr Ala Thr Leu Lys Lys Leu Val Cys Leu Asn Thr Lys Thr 
    450                 455                 460                 


Cys Pro Tyr Val Ser Phe Arg Val Pro Asp Ala Ser Gln Asp Asp Gly 
465                 470                 475                 480 


Pro Ala Val Glu Arg Pro Ser Thr Glu Leu 
                485                 490 


<210>  23
<211>  3356
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (98)..(1912)

<400>  23
gtccaggaac tcctcagcag cgcctccttc agctccacag ccagacgccc tcagacagca       60

aagcctaccc ccgcgccgcg ccctgcccgc cgctgcg atg ctc gcc cgc gcc ctg       115
                                         Met Leu Ala Arg Ala Leu          
                                         1               5                

ctg ctg tgc gcg gtc ctg gcg ctc agc cat aca gca aat cct tgc tgt        163
Leu Leu Cys Ala Val Leu Ala Leu Ser His Thr Ala Asn Pro Cys Cys           
            10                  15                  20                    

tcc cac cca tgt caa aac cga ggt gta tgt atg agt gtg gga ttt gac        211
Ser His Pro Cys Gln Asn Arg Gly Val Cys Met Ser Val Gly Phe Asp           
        25                  30                  35                        

cag tat aag tgc gat tgt acc cgg aca gga ttc tat gga gaa aac tgc        259
Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly Phe Tyr Gly Glu Asn Cys           
    40                  45                  50                            

tca aca ccg gaa ttt ttg aca aga ata aaa tta ttt ctg aaa ccc act        307
Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys Leu Phe Leu Lys Pro Thr           
55                  60                  65                  70            

cca aac aca gtg cac tac ata ctt acc cac ttc aag gga ttt tgg aac        355
Pro Asn Thr Val His Tyr Ile Leu Thr His Phe Lys Gly Phe Trp Asn           
                75                  80                  85                

gtt gtg aat aac att ccc ttc ctt cga aat gca att atg agt tat gtg        403
Val Val Asn Asn Ile Pro Phe Leu Arg Asn Ala Ile Met Ser Tyr Val           
            90                  95                  100                   

ttg aca tcc aga tca cat ttg att gac agt cca cca act tac aat gct        451
Leu Thr Ser Arg Ser His Leu Ile Asp Ser Pro Pro Thr Tyr Asn Ala           
        105                 110                 115                       

gac tat ggc tac aaa agc tgg gaa gcc ttc tct aac ctc tcc tat tat        499
Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe Ser Asn Leu Ser Tyr Tyr           
    120                 125                 130                           

act aga gcc ctt cct cct gtg cct gat gat tgc ccg act ccc ttg ggt        547
Thr Arg Ala Leu Pro Pro Val Pro Asp Asp Cys Pro Thr Pro Leu Gly           
135                 140                 145                 150           

gtc aaa ggt aaa aag cag ctt cct gat tca aat gag att gtg gaa aaa        595
Val Lys Gly Lys Lys Gln Leu Pro Asp Ser Asn Glu Ile Val Glu Lys           
                155                 160                 165               

ttg ctt cta aga aga aag ttc atc cct gat ccc cag ggc tca aac atg        643
Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp Pro Gln Gly Ser Asn Met           
            170                 175                 180                   

atg ttt gca ttc ttt gcc cag cac ttc acg cat cag ttt ttc aag aca        691
Met Phe Ala Phe Phe Ala Gln His Phe Thr His Gln Phe Phe Lys Thr           
        185                 190                 195                       

gat cat aag cga ggg cca gct ttc acc aac ggg ctg ggc cat ggg gtg        739
Asp His Lys Arg Gly Pro Ala Phe Thr Asn Gly Leu Gly His Gly Val           
    200                 205                 210                           

gac tta aat cat att tac ggt gaa act ctg gct aga cag cgt aaa ctg        787
Asp Leu Asn His Ile Tyr Gly Glu Thr Leu Ala Arg Gln Arg Lys Leu           
215                 220                 225                 230           

cgc ctt ttc aag gat gga aaa atg aaa tat cag ata att gat gga gag        835
Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr Gln Ile Ile Asp Gly Glu           
                235                 240                 245               

atg tat cct ccc aca gtc aaa gat act cag gca gag atg atc tac cct        883
Met Tyr Pro Pro Thr Val Lys Asp Thr Gln Ala Glu Met Ile Tyr Pro           
            250                 255                 260                   

cct caa gtc cct gag cat cta cgg ttt gct gtg ggg cag gag gtc ttt        931
Pro Gln Val Pro Glu His Leu Arg Phe Ala Val Gly Gln Glu Val Phe           
        265                 270                 275                       

ggt ctg gtg cct ggt ctg atg atg tat gcc aca atc tgg ctg cgg gaa        979
Gly Leu Val Pro Gly Leu Met Met Tyr Ala Thr Ile Trp Leu Arg Glu           
    280                 285                 290                           

cac aac aga gta tgc gat gtg ctt aaa cag gag cat cct gaa tgg ggt       1027
His Asn Arg Val Cys Asp Val Leu Lys Gln Glu His Pro Glu Trp Gly           
295                 300                 305                 310           

gat gag cag ttg ttc cag aca agc agg cta ata ctg ata gga gag act       1075
Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu Ile Leu Ile Gly Glu Thr           
                315                 320                 325               

att aag att gtg att gaa gat tat gtg caa cac ttg agt ggc tat cac       1123
Ile Lys Ile Val Ile Glu Asp Tyr Val Gln His Leu Ser Gly Tyr His           
            330                 335                 340                   

ttc aaa ctg aaa ttt gac cca gaa cta ctt ttc aac aaa caa ttc cag       1171
Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu Phe Asn Lys Gln Phe Gln           
        345                 350                 355                       

tac caa aat cgt att gct gct gaa ttt aac acc ctc tat cac tgg cat       1219
Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn Thr Leu Tyr His Trp His           
    360                 365                 370                           

ccc ctt ctg cct gac acc ttt caa att cat gac cag aaa tac aac tat       1267
Pro Leu Leu Pro Asp Thr Phe Gln Ile His Asp Gln Lys Tyr Asn Tyr           
375                 380                 385                 390           

caa cag ttt atc tac aac aac tct ata ttg ctg gaa cat gga att acc       1315
Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu Leu Glu His Gly Ile Thr           
                395                 400                 405               

cag ttt gtt gaa tca ttc acc agg caa att gct ggc agg gtt gct ggt       1363
Gln Phe Val Glu Ser Phe Thr Arg Gln Ile Ala Gly Arg Val Ala Gly           
            410                 415                 420                   

ggt agg aat gtt cca ccc gca gta cag aaa gta tca cag gct tcc att       1411
Gly Arg Asn Val Pro Pro Ala Val Gln Lys Val Ser Gln Ala Ser Ile           
        425                 430                 435                       

gac cag agc agg cag atg aaa tac cag tct ttt aat gag tac cgc aaa       1459
Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser Phe Asn Glu Tyr Arg Lys           
    440                 445                 450                           

cgc ttt atg ctg aag ccc tat gaa tca ttt gaa gaa ctt aca gga gaa       1507
Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe Glu Glu Leu Thr Gly Glu           
455                 460                 465                 470           

aag gaa atg tct gca gag ttg gaa gca ctc tat ggt gac atc gat gct       1555
Lys Glu Met Ser Ala Glu Leu Glu Ala Leu Tyr Gly Asp Ile Asp Ala           
                475                 480                 485               

gtg gag ctg tat cct gcc ctt ctg gta gaa aag cct cgg cca gat gcc       1603
Val Glu Leu Tyr Pro Ala Leu Leu Val Glu Lys Pro Arg Pro Asp Ala           
            490                 495                 500                   

atc ttt ggt gaa acc atg gta gaa gtt gga gca cca ttc tcc ttg aaa       1651
Ile Phe Gly Glu Thr Met Val Glu Val Gly Ala Pro Phe Ser Leu Lys           
        505                 510                 515                       

gga ctt atg ggt aat gtt ata tgt tct cct gcc tac tgg aag cca agc       1699
Gly Leu Met Gly Asn Val Ile Cys Ser Pro Ala Tyr Trp Lys Pro Ser           
    520                 525                 530                           

act ttt ggt gga gaa gtg ggt ttt caa atc atc aac act gcc tca att       1747
Thr Phe Gly Gly Glu Val Gly Phe Gln Ile Ile Asn Thr Ala Ser Ile           
535                 540                 545                 550           

cag tct ctc atc tgc aat aac gtg aag ggc tgt ccc ttt act tca ttc       1795
Gln Ser Leu Ile Cys Asn Asn Val Lys Gly Cys Pro Phe Thr Ser Phe           
                555                 560                 565               

agt gtt cca gat cca gag ctc att aaa aca gtc acc atc aat gca agt       1843
Ser Val Pro Asp Pro Glu Leu Ile Lys Thr Val Thr Ile Asn Ala Ser           
            570                 575                 580                   

tct tcc cgc tcc gga cta gat gat atc aat ccc aca gta cta cta aaa       1891
Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn Pro Thr Val Leu Leu Lys           
        585                 590                 595                       

gaa cgt tcg act gaa ctg tag aagtctaatg atcatattta tttatttata          1942
Glu Arg Ser Thr Glu Leu                                                   
    600                                                                   

tgaaccatgt ctattaattt aattatttaa taatatttat attaaactcc ttatgttact     2002

taacatcttc tgtaacagaa gtcagtactc ctgttgcgga gaaaggagtc atacttgtga     2062

agacttttat gtcactactc taaagatttt gctgttgctg ttaagtttgg aaaacagttt     2122

ttattctgtt ttataaacca gagagaaatg agttttgacg tctttttact tgaatttcaa     2182

cttatattat aagaacgaaa gtaaagatgt ttgaatactt aaacactgtc acaagatggc     2242

aaaatgctga aagtttttac actgtcgatg tttccaatgc atcttccatg atgcattaga     2302

agtaactaat gtttgaaatt ttaaagtact tttggttatt tttctgtcat caaacaaaaa     2362

caggtatcag tgcattatta aatgaatatt taaattagac attaccagta atttcatgtc     2422

tactttttaa aatcagcaat gaaacaataa tttgaaattt ctaaattcat agggtagaat     2482

cacctgtaaa agcttgtttg atttcttaaa gttattaaac ttgtacatat accaaaaaga     2542

agctgtcttg gatttaaatc tgtaaaatca gtagaaattt tactacaatt gcttgttaaa     2602

atattttata agtgatgttc ctttttcacc aagagtataa acctttttag tgtgactgtt     2662

aaaacttcct tttaaatcaa aatgccaaat ttattaaggt ggtggagcca ctgcagtgtt     2722

atcttaaaat aagaatattt tgttgagata ttccagaatt tgtttatatg gctggtaaca     2782

tgtaaaatct atatcagcaa aagggtctac ctttaaaata agcaataaca aagaagaaaa     2842

ccaaattatt gttcaaattt aggtttaaac ttttgaagca aacttttttt tatccttgtg     2902

cactgcaggc ctggtactca gattttgcta tgaggttaat gaagtaccaa gctgtgcttg     2962

aataatgata tgttttctca gattttctgt tgtacagttt aatttagcag tccatatcac     3022

attgcaaaag tagcaatgac ctcataaaat acctcttcaa aatgcttaaa ttcatttcac     3082

acattaattt tatctcagtc ttgaagccaa ttcagtaggt gcattggaat caagcctggc     3142

tacctgcatg ctgttccttt tcttttcttc ttttagccat tttgctaaga gacacagtct     3202

tctcatcact tcgtttctcc tattttgttt tactagtttt aagatcagag ttcactttct     3262

ttggactctg cctatatttt cttacctgaa cttttgcaag ttttcaggta aacctcagct     3322

caggactgct atttagctcc tcttaagaag atta                                 3356


<210>  24
<211>  604
<212>  PRT
<213>  homo sapiens

<400>  24

Met Leu Ala Arg Ala Leu Leu Leu Cys Ala Val Leu Ala Leu Ser His 
1               5                   10                  15      


Thr Ala Asn Pro Cys Cys Ser His Pro Cys Gln Asn Arg Gly Val Cys 
            20                  25                  30          


Met Ser Val Gly Phe Asp Gln Tyr Lys Cys Asp Cys Thr Arg Thr Gly 
        35                  40                  45              


Phe Tyr Gly Glu Asn Cys Ser Thr Pro Glu Phe Leu Thr Arg Ile Lys 
    50                  55                  60                  


Leu Phe Leu Lys Pro Thr Pro Asn Thr Val His Tyr Ile Leu Thr His 
65                  70                  75                  80  


Phe Lys Gly Phe Trp Asn Val Val Asn Asn Ile Pro Phe Leu Arg Asn 
                85                  90                  95      


Ala Ile Met Ser Tyr Val Leu Thr Ser Arg Ser His Leu Ile Asp Ser 
            100                 105                 110         


Pro Pro Thr Tyr Asn Ala Asp Tyr Gly Tyr Lys Ser Trp Glu Ala Phe 
        115                 120                 125             


Ser Asn Leu Ser Tyr Tyr Thr Arg Ala Leu Pro Pro Val Pro Asp Asp 
    130                 135                 140                 


Cys Pro Thr Pro Leu Gly Val Lys Gly Lys Lys Gln Leu Pro Asp Ser 
145                 150                 155                 160 


Asn Glu Ile Val Glu Lys Leu Leu Leu Arg Arg Lys Phe Ile Pro Asp 
                165                 170                 175     


Pro Gln Gly Ser Asn Met Met Phe Ala Phe Phe Ala Gln His Phe Thr 
            180                 185                 190         


His Gln Phe Phe Lys Thr Asp His Lys Arg Gly Pro Ala Phe Thr Asn 
        195                 200                 205             


Gly Leu Gly His Gly Val Asp Leu Asn His Ile Tyr Gly Glu Thr Leu 
    210                 215                 220                 


Ala Arg Gln Arg Lys Leu Arg Leu Phe Lys Asp Gly Lys Met Lys Tyr 
225                 230                 235                 240 


Gln Ile Ile Asp Gly Glu Met Tyr Pro Pro Thr Val Lys Asp Thr Gln 
                245                 250                 255     


Ala Glu Met Ile Tyr Pro Pro Gln Val Pro Glu His Leu Arg Phe Ala 
            260                 265                 270         


Val Gly Gln Glu Val Phe Gly Leu Val Pro Gly Leu Met Met Tyr Ala 
        275                 280                 285             


Thr Ile Trp Leu Arg Glu His Asn Arg Val Cys Asp Val Leu Lys Gln 
    290                 295                 300                 


Glu His Pro Glu Trp Gly Asp Glu Gln Leu Phe Gln Thr Ser Arg Leu 
305                 310                 315                 320 


Ile Leu Ile Gly Glu Thr Ile Lys Ile Val Ile Glu Asp Tyr Val Gln 
                325                 330                 335     


His Leu Ser Gly Tyr His Phe Lys Leu Lys Phe Asp Pro Glu Leu Leu 
            340                 345                 350         


Phe Asn Lys Gln Phe Gln Tyr Gln Asn Arg Ile Ala Ala Glu Phe Asn 
        355                 360                 365             


Thr Leu Tyr His Trp His Pro Leu Leu Pro Asp Thr Phe Gln Ile His 
    370                 375                 380                 


Asp Gln Lys Tyr Asn Tyr Gln Gln Phe Ile Tyr Asn Asn Ser Ile Leu 
385                 390                 395                 400 


Leu Glu His Gly Ile Thr Gln Phe Val Glu Ser Phe Thr Arg Gln Ile 
                405                 410                 415     


Ala Gly Arg Val Ala Gly Gly Arg Asn Val Pro Pro Ala Val Gln Lys 
            420                 425                 430         


Val Ser Gln Ala Ser Ile Asp Gln Ser Arg Gln Met Lys Tyr Gln Ser 
        435                 440                 445             


Phe Asn Glu Tyr Arg Lys Arg Phe Met Leu Lys Pro Tyr Glu Ser Phe 
    450                 455                 460                 


Glu Glu Leu Thr Gly Glu Lys Glu Met Ser Ala Glu Leu Glu Ala Leu 
465                 470                 475                 480 


Tyr Gly Asp Ile Asp Ala Val Glu Leu Tyr Pro Ala Leu Leu Val Glu 
                485                 490                 495     


Lys Pro Arg Pro Asp Ala Ile Phe Gly Glu Thr Met Val Glu Val Gly 
            500                 505                 510         


Ala Pro Phe Ser Leu Lys Gly Leu Met Gly Asn Val Ile Cys Ser Pro 
        515                 520                 525             


Ala Tyr Trp Lys Pro Ser Thr Phe Gly Gly Glu Val Gly Phe Gln Ile 
    530                 535                 540                 


Ile Asn Thr Ala Ser Ile Gln Ser Leu Ile Cys Asn Asn Val Lys Gly 
545                 550                 555                 560 


Cys Pro Phe Thr Ser Phe Ser Val Pro Asp Pro Glu Leu Ile Lys Thr 
                565                 570                 575     


Val Thr Ile Asn Ala Ser Ser Ser Arg Ser Gly Leu Asp Asp Ile Asn 
            580                 585                 590         


Pro Thr Val Leu Leu Lys Glu Arg Ser Thr Glu Leu 
        595                 600                 


<210>  25
<211>  10049
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (267)..(1673)

<400>  25
gcgccgcctc cttcggcgtt cgccccacgg accggcaggc ggcggaccgc ggcccaggct       60

gaagctcagg gccctgtctg ctctgtggac tcaacagttt gtggcaagac aagctcagaa      120

ctgagaagct gtcaccacag ttctggaggc tgggaagttc aagatcaaag tgccagcaga      180

ttcagtgtca tgtgaggacg tgcttcctgc ttcatagata agagtagctt ggagctcggc      240

ggcacaacca gcaccatctg gtcgcg atg gtg gac acg gaa agc cca ctc tgc       293
                             Met Val Asp Thr Glu Ser Pro Leu Cys          
                             1               5                            

ccc ctc tcc cca ctc gag gcc ggc gat cta gag agc ccg tta tct gaa        341
Pro Leu Ser Pro Leu Glu Ala Gly Asp Leu Glu Ser Pro Leu Ser Glu           
10                  15                  20                  25            

gag ttc ctg caa gaa atg gga aac atc caa gag att tcg caa tcc atc        389
Glu Phe Leu Gln Glu Met Gly Asn Ile Gln Glu Ile Ser Gln Ser Ile           
                30                  35                  40                

ggc gag gat agt tct gga agc ttt ggc ttt acg gaa tac cag tat tta        437
Gly Glu Asp Ser Ser Gly Ser Phe Gly Phe Thr Glu Tyr Gln Tyr Leu           
            45                  50                  55                    

gga agc tgt cct ggc tca gat ggc tcg gtc atc acg gac acg ctt tca        485
Gly Ser Cys Pro Gly Ser Asp Gly Ser Val Ile Thr Asp Thr Leu Ser           
        60                  65                  70                        

cca gct tcg agc ccc tcc tcg gtg act tat cct gtg gtc ccc ggc agc        533
Pro Ala Ser Ser Pro Ser Ser Val Thr Tyr Pro Val Val Pro Gly Ser           
    75                  80                  85                            

gtg gac gag tct ccc agt gga gca ttg aac atc gaa tgt aga atc tgc        581
Val Asp Glu Ser Pro Ser Gly Ala Leu Asn Ile Glu Cys Arg Ile Cys           
90                  95                  100                 105           

ggg gac aag gcc tca ggc tat cat tac gga gtc cac gcg tgt gaa ggc        629
Gly Asp Lys Ala Ser Gly Tyr His Tyr Gly Val His Ala Cys Glu Gly           
                110                 115                 120               

tgc aag ggc ttc ttt cgg cga acg att cga ctc aag ctg gtg tat gac        677
Cys Lys Gly Phe Phe Arg Arg Thr Ile Arg Leu Lys Leu Val Tyr Asp           
            125                 130                 135                   

aag tgc gac cgc agc tgc aag atc cag aaa aag aac aga aac aaa tgc        725
Lys Cys Asp Arg Ser Cys Lys Ile Gln Lys Lys Asn Arg Asn Lys Cys           
        140                 145                 150                       

cag tat tgt cga ttt cac aag tgc ctt tct gtc ggg atg tca cac aac        773
Gln Tyr Cys Arg Phe His Lys Cys Leu Ser Val Gly Met Ser His Asn           
    155                 160                 165                           

gcg att cgt ttt gga cga atg cca aga tct gag aaa gca aaa ctg aaa        821
Ala Ile Arg Phe Gly Arg Met Pro Arg Ser Glu Lys Ala Lys Leu Lys           
170                 175                 180                 185           

gca gaa att ctt acc tgt gaa cat gac ata gaa gat tct gaa act gca        869
Ala Glu Ile Leu Thr Cys Glu His Asp Ile Glu Asp Ser Glu Thr Ala           
                190                 195                 200               

gat ctc aaa tct ctg gcc aag aga atc tac gag gcc tac ttg aag aac        917
Asp Leu Lys Ser Leu Ala Lys Arg Ile Tyr Glu Ala Tyr Leu Lys Asn           
            205                 210                 215                   

ttc aac atg aac aag gtc aaa gcc cgg gtc atc ctc tca gga aag gcc        965
Phe Asn Met Asn Lys Val Lys Ala Arg Val Ile Leu Ser Gly Lys Ala           
        220                 225                 230                       

agt aac aat cca cct ttt gtc ata cat gat atg gag aca ctg tgt atg       1013
Ser Asn Asn Pro Pro Phe Val Ile His Asp Met Glu Thr Leu Cys Met           
    235                 240                 245                           

gct gag aag acg ctg gtg gcc aag ctg gtg gcc aat ggc atc cag aac       1061
Ala Glu Lys Thr Leu Val Ala Lys Leu Val Ala Asn Gly Ile Gln Asn           
250                 255                 260                 265           

aag gag gcg gag gtc cgc atc ttt cac tgc tgc cag tgc acg tca gtg       1109
Lys Glu Ala Glu Val Arg Ile Phe His Cys Cys Gln Cys Thr Ser Val           
                270                 275                 280               

gag acc gtc acg gag ctc acg gaa ttc gcc aag gcc atc cca ggc ttc       1157
Glu Thr Val Thr Glu Leu Thr Glu Phe Ala Lys Ala Ile Pro Gly Phe           
            285                 290                 295                   

gca aac ttg gac ctg aac gat caa gtg aca ttg cta aaa tac gga gtt       1205
Ala Asn Leu Asp Leu Asn Asp Gln Val Thr Leu Leu Lys Tyr Gly Val           
        300                 305                 310                       

tat gag gcc ata ttc gcc atg ctg tct tct gtg atg aac aaa gac ggg       1253
Tyr Glu Ala Ile Phe Ala Met Leu Ser Ser Val Met Asn Lys Asp Gly           
    315                 320                 325                           

atg ctg gta gcg tat gga aat ggg ttt ata act cgt gaa ttc cta aaa       1301
Met Leu Val Ala Tyr Gly Asn Gly Phe Ile Thr Arg Glu Phe Leu Lys           
330                 335                 340                 345           

agc cta agg aaa ccg ttc tgt gat atc atg gaa ccc aag ttt gat ttt       1349
Ser Leu Arg Lys Pro Phe Cys Asp Ile Met Glu Pro Lys Phe Asp Phe           
                350                 355                 360               

gcc atg aag ttc aat gca ctg gaa ctg gat gac agt gat atc tcc ctt       1397
Ala Met Lys Phe Asn Ala Leu Glu Leu Asp Asp Ser Asp Ile Ser Leu           
            365                 370                 375                   

ttt gtg gct gct atc att tgc tgt gga gat cgt cct ggc ctt cta aac       1445
Phe Val Ala Ala Ile Ile Cys Cys Gly Asp Arg Pro Gly Leu Leu Asn           
        380                 385                 390                       

gta gga cac att gaa aaa atg cag gag ggt att gta cat gtg ctc aga       1493
Val Gly His Ile Glu Lys Met Gln Glu Gly Ile Val His Val Leu Arg           
    395                 400                 405                           

ctc cac ctg cag agc aac cac ccg gac gat atc ttt ctc ttc cca aaa       1541
Leu His Leu Gln Ser Asn His Pro Asp Asp Ile Phe Leu Phe Pro Lys           
410                 415                 420                 425           

ctt ctt caa aaa atg gca gac ctc cgg cag ctg gtg acg gag cat gcg       1589
Leu Leu Gln Lys Met Ala Asp Leu Arg Gln Leu Val Thr Glu His Ala           
                430                 435                 440               

cag ctg gtg cag atc atc aag aag acg gag tcg gat gct gcg ctg cac       1637
Gln Leu Val Gln Ile Ile Lys Lys Thr Glu Ser Asp Ala Ala Leu His           
            445                 450                 455                   

ccg cta ctg cag gag atc tac agg gac atg tac tga gttccttcag            1683
Pro Leu Leu Gln Glu Ile Tyr Arg Asp Met Tyr                               
        460                 465                                           

atcagccaca ccttttccag gagttctgaa gctgacagca ctacaaagga gacgggggag     1743

cagcacgatt ttgcacaaat atccaccact ttaaccttag agcttggaca gtctgagctg     1803

taggtaaccg gcatattatt ccatatcttt gttttaacca gtacttctaa gagcatagaa     1863

ctcaaatgct gggggtaggt ggctaatctc aggactggga agattacggc gaattatgct     1923

caatggtctg attttaactc acccgatgtt aatcaatgca cattgcttta gatcacattc     1983

gtgatttacc atttaattaa ctggtaacct caaaattcgt ggcctgtctt cccattcacc     2043

ccgcttttga ctattgtgct cctttataat tctgaaaact aatcagcact ttttaacaat     2103

gtttataatc ctataagtct agatgtatcc aaaggtgaag tatgtaaaaa gcagcaaaat     2163

atttatttca aagacttcac ttctgtttcc tgaatctaaa gaaagacaac atgctgcttt     2223

ttaatcatag gatggagaat tttaaagaac tgtttgggcc aggcacagtc gctcatactt     2283

gtaatcccag cactttggga ggccgaggcg ggtggatcac aaggtcagca gatcgagacc     2343

atcctggcca acatggtgaa accctgtctc tactaaaaat acaaaaatta gccgggtgtg     2403

gtggcacatg cctgtaatcc cagctactcg ggaagctgag gcaggagaat tgcttgaacc     2463

agggagttgg aggttgcagt gagctaagac tgcaccactg cactccagcc tggtgacaga     2523

acgagactct gtcttaaaaa caaacaaaca aaaaaaaaat ctgttagata agctatcaaa     2583

atgcagctgt tgttttgttt ttggctcact gttttcgtgg ttgtaactaa tatgtggaaa     2643

ggcccatttc caggtttgcg tagaagagcc cagaaaacag agtctcaaga cccccgctct     2703

ggactgtcat aagctagcac ccgtggtaag cgggacgaga caagctcccg aagcccgcca     2763

gcttcctgct ccactcagct ccgtccagtc aacctgaacc cacccagtcc agctgtctgt     2823

gggaatggtg gtgttcttag ggacagactg acaccttact tgtcagtgtt cctccgggcc     2883

ccatttggca gctcccgtat cttttgttat gttgctttta aagatatgat gttttattgt     2943

tttaactctt ggtgacagta gatgctctct ggagcgcaga cgaggcacat gtgtcttcat     3003

agcctgggct gggtgggagc cagtcaccct gcggatcgag agagggggta gagtcttctt     3063

caaatggcag ttttacttca aatggcagat ttcacaagag ttggttattt tttacaatgg     3123

tttaggttgt taagtctcct ttgtatgtaa ggtagttttt tcaacatcta aaatttttgt     3183

tttagccttc aaaaccaact taccaacctc agtccagctg ggaaggcagc gttgattatg     3243

gtagtttgtc aagaatatat ggacctggaa acactttctc tctctgtcca cctggtagat     3303

aaattgtcct gttgagaatt tttagatctg gactggaact gccaggacca ccgcctccag     3363

ggagtcgctg ggcacctgga ggtatcgtcg atgcctctcc cccatcttta gaaaatttgg     3423

ctcttctgag gtcattatta ttttaagaat gattaggatt gataagggtc ccatgaccag     3483

cattatgaaa atgcgagagt gggaaggaca cagtgtgaga cttccactag aaaaaagtga     3543

aagttagggt taggacatcc ttttttaaaa attacaaatt tagtccgttt tggtttttgt     3603

aatcaggcta ggcacagtgg ctcacacatg gaatcccagc actttgggag gccgaggtgg     3663

gaggatcact tgagcccagg agttcgagac cagcctaggc aacatagcaa gaccctgtct     3723

gtacacaaaa tttaaaaatt agttcatcgg ggtggcacac atcagtagtc ccagctactc     3783

tgcaggctga ggtgggagga ttgcttgaac ccaggaggtc gaggctgcag tgagctgtga     3843

tctcaccact gcattccagc ctgggtgaca gagttagatt ccaccctctc ccaccccggc     3903

aaaaaaaaaa aaaaaagatg caatcaaagg ggctgttggc cagcaatggc agcagcagcg     3963

gcgggcagtc tgcccaagtg tcttaggaac caaaagcaaa taaaagtgtt tccatatatg     4023

ccaccagcca agtggccatc ctaattcaga aagaagctag cctttgagtg tctgtcatgg     4083

tgcatccgtt tcagtattat ttcctaaaat gagaagcccc tgtgtcaaca agatccaggg     4143

gctggagccc aatgccaagc ctgtgttgtc cccagcgacc ctgcagctgc tcgctctgat     4203

gtaccctgtg ccattcaagg agatgtggtc caggaaagtg agcctcatgg ttttcagaga     4263

agtcattgtt ctgtttacat tttcataaaa cctgtttaaa atagctcccc gtctcaggct     4323

ttcagcagta acagtgagct gactggcaag ttcgatgtta gctcccggga cactcagcag     4383

cgatggtgag cattttggtt tccttaaggc ccagcaagac ttccagggac atctctggtg     4443

aagccagaat ggagacaccc gtgacctcag gctgaaagtc actcgacatt ggtctcttgt     4503

gttgataggg aaggaaatca ggcattccta tttctttaaa taacaaaacc actaattgcc     4563

actcaatgct ggaatatttt gggtcaccta atcatagatt tctcagggca tcaatactca     4623

aatataggct gattatgccc cagttcaaat gggaactatt aacagagtgc atttcttgct     4683

tgctgggttt caacagacat cagccaaaag aacaaaagag atgtcaggac agattccagg     4743

agtgtcggag cacatgtgtg gcacccgctc cctctggcag cgaatgtagg aagtcgccaa     4803

atttacccac tcttcaacaa gtcattgttt aaacacggtt tttcattttc tcaactttta     4863

atagcaaaaa gtgccaaagt cctcagagac ctaacagcct tggtctaccg tgctgaccag     4923

ggtgaaggca cggcgaggga ctcctcccag acgtgcctct tgtgtgccag ctggctgtgg     4983

ctcgggagca gacgcaggcc tctccattgt ccaggggagc ctggcggcgc atccctcctc     5043

tcccacctcc tggcacttcc agctgggtgt cccacatgtt ggattccgtc cccaccacac     5103

ttccagagac cggagaactg tgcagggcct aaggccgttt ggatgaattg tcaaaacaag     5163

atgcttccag ttacagcggc aggagcggga ctgggagcac gggctgacgg ctgctggtgc     5223

ctttcttccc acctcgcttg cctgtttccg cttgaccctt cctccagctc cgatgagaag     5283

agtataaagc atcttcctaa cgggtgtgtt tgctatacga acataatgga cgtgaagtgg     5343

ggcagaaacc cagaactcag cattcaagga tgcccaggag agctgtccct gttttaaaga     5403

gctgtgtttt gttttgtttc gcatttagag agcagacaag gcacccttct gctgcgctga     5463

tacgtttctt acactgggcc attttagacc cccagggaaa cagccttcct ggagcgttgt     5523

ctggaggttc cagggacagg gcagcctccc agagccgagc aagagctcaa ggtacaaatg     5583

agagatttgc tataccgtga gaagtcaaca acttagccac cacttccccg caatggacca     5643

tgtaacaaat acctcagcag gccctgcaaa aggccatgct agagctgagg cgcacagcct     5703

gtggcctctg tagttagggc aggtgggatg gagactcctt gagtgcacac acctgagcct     5763

gcccacacac aggggagcag catctcgtat gacgtctgga aggaacttcg gttgtgtaaa     5823

gggagccttg aagatacgtg caaaaggtgc taccccaatt tggtgaaact gacattgggc     5883

acgtcttggg cttaggagaa gcggccgatg gtcccggcct gcagtgacaa acccccctcc     5943

ccgcaccgcc cccagcaccc cctctcctct tcacctcttc ctgctggcca cgaggaagcc     6003

acttcctcag agagacccta ccagatgcgg atggaaacag atgcaccaaa gcaagccctg     6063

atgaaaccgc gacttcctaa ggtctgtctc ctctgaactt gcacctgggc ctctctgtgt     6123

ttggttccaa gcacttccca cctcaaactc ccattttcaa accactgtat ctctgcgcac     6183

atctgctact taccagccgc atacatgatg gagggttttt tggtcctgat ccagtggcca     6243

cacctgtctt tgaaatgtct cactgaactc cagttttaaa atagattcat tgcttcaaca     6303

cagcaagccc aatgcaccca gctaagactg gcttgaccga cagcctggcc tttggtgggg     6363

ggcttcctgg ggcctgggga aagctggcca ccttcaacag ctggtacctc ttcaacagtg     6423

tggcctttca aaatgcagat gccaccagga gaacatgccc acagctcacc acctatggat     6483

gccatggctc tgggcagctt tcaaagcagg ttcctgtggt ctcctcagct gtttgagggg     6543

gtaacagcaa atcagcctcc attttaaaat gaaaacacca gcctccagat gtagggcctg     6603

ctgggtgttg ctagccgctg gtccccaggc acggtgcact ttctccacct cctgcagcct     6663

ccctgttgtt tctagactct tgcacctggt gagtgcaagg ataggtgacc caggggcctg     6723

cagccttgtc ctcagctccc atctcctgga ctgccagcct caccctctgc agttagcatg     6783

gttggcctga tgcagggatc ccgagggatt actttttaga ccttctttca cattcagaaa     6843

agtagtatag attcaggaga ggcaagaaaa ttatgctgtc catagaagtc acccatgaag     6903

actgatgcca ccacctgaag gctcatgatt gttaaaaatg tccacgggaa cctctcgtcc     6963

acaggaggtt tgtctcaaca cttcccattt ttacggcatt ggcattgcca agcatgggga     7023

agtatctgct cttctcatgt taaaagtggc ccagcttttc ttaactcagt ccaagctgac     7083

ttgtttagct gcactggaat ttcttaccaa ccaaatattt gcatcgagca aagggggctg     7143

tgtgcacctc cctaatggca gcgatgatgg ctgctgtcat tcaagcccat cttcagacgt     7203

cacagtctgg aagtgaaatg tccacaaaca tctgtggcag aaaaggctat acggaccacc     7263

cagttgtgct gcagctttac agagcaagga agggttgtgg caaataaatg attaacctgc     7323

ctcgactgtg ctgagggcaa caaaggccat ctcaccaaag gattattcga tgccattaaa     7383

tcatcccgtg accttcctgc ttccgagtcc atggcctttg cccagggcat gtactcccct     7443

gagaggcctt ctgcctagaa agatctatga ctgggttcca aagttgaggc ctaggttttt     7503

gctgggattt agatattttc aggcaccatt ttgacagcat tcaggaaaac ggttattgac     7563

cccatagact agggtaagaa taaaggcaat aaatttggtc tgactcagaa tataggagat     7623

ccatatattt ctctggaaac cacagtgtac actaaaatgt gaaattgaag gttttgttaa     7683

aaagaaaaag ataatgagct tcatgctttg tttaattaca taatgatttc cattacgcta     7743

tttctgtgaa atgcagcagg ttcttaaacg ttatttcagt ggcatgggct ggaagcttat     7803

cacaaaaagc catgtgtgtg gccttatcag aacagaaaga gacaggctgg tgcccaaggc     7863

tgctgcctgc tccacctttt gccagctctg gacatctgag gacgtcccgg cagatctgga     7923

atggggccct caactgacca tttgcttctc agaatttcag tttgagacat gagaggtata     7983

atcagttact tttctccccc cagagaaacc cttttgtgag gggagaggag ctatggtatg     8043

tggttcagct gaaacacata caactgcatc cttttggagt cctttgccaa caaaaacaga     8103

ccaacagacc agatggtgtc catgttcaat atcatgtctt gatggacgca gctgatgacc     8163

tcaaatactt gagtggtctc atggctgtta gatggattat ttgaaaaaaa aaaaaaaaaa     8223

agagagaaaa aataattgat ttttacatca gagatagcaa actaagacct ggggaggggg     8283

gtcagctttt attttatttt atttttttta agtttgctag ttgggtcaaa tgtgaggagg     8343

agggagtcta cctgccacct cttctcttgc ccctcttctg cccacacatc cagcatccaa     8403

aatccattca tttaatgaat tgataaagtg ccgtgcaaac tggtgcacaa acaggccccc     8463

agtccacgca gcctggctcc taggaaaagt ggtgaccggg cgtggggggg catgccgcag     8523

ccctgggaca cagtcgggca ccttccccgg acccccaggc cttggctgtg cctcaagtca     8583

gagagggtca gccttcaggc cccggagacg agtgactggc cgatcatttc acaataaaat     8643

cactcacttt tggcaacttc acttttttta aggcacagtc agttcctttt ctcatgtacc     8703

tcacaaaaga tgaagaccat gtagtactct ttttggtaaa gttacagtgt tcatgttaaa     8763

tatcactttt ttctacattg tgtggtaaaa agaactacgt taatagctat atcttaaata     8823

ctgtgatttg actttttgaa aaatatccta atacaaatat tttactaact tacaatcact     8883

catttaataa gaaacatttg gattcttttg aaatcagtgt taattgactc atattcttaa     8943

aagcctggct cttgacccta ttggaaacac aaaggaagct gaaatcaaac atctaaaata     9003

cactgcgtac acgtgtgcgt gcacacacac acacacacac acacacacac agctcttcat     9063

ttctcctgag ccatgcagaa tttactttca atgtggaaat ctgttccctt taccacactg     9123

tatatgcaca gagcacaaga gaggctatct ctagtcactt ccaccagcga ggccttagac     9183

tccgtattag aggccaccga tttcatacaa cagtgtttcg ctaaagaccc ttcactattc     9243

ttgtttagta aatagctgtc tgctcttcag ggaactgtta cctatgggtt attaccaaag     9303

aacgctggca attggaaatg tcctgatgga aattctttgc acgtgccggt tctctggcat     9363

cctccaggtg gcccaaccca aagcagaaag cagaaaccac agaccccgtg agtctcccca     9423

taccttgttt ccaataactt ggcaaaactt cttggtgcat attggttaca ccctctggga     9483

ttcataatgc cattaggcta aaaccctaag agagagggtt gacagaaaca cacgcgagaa     9543

tgaggcagat cccagagcaa ggactgggcc cagactctcc acatgtgctc tactagtgag     9603

tgccttatac tctcagtatt ttggggctta cagcttctta tttgtgctaa aaaggtgcag     9663

ttccaaagta ggaactgcca cacaggcccc agcatcctct ctccaacttc atacctctct     9723

cctggtgggg ggagcgggca tccaggacct ccggaatcaa ggatgtgcag agaagagcga     9783

aagtaatttt tctagtcaca tgaactgatt ggttccaggc aattagaaaa tggctataaa     9843

ataaccttaa ttttaaaaaa aaatcttggg tcttcgtttt cctattagga gactgaactg     9903

accacatgta ttgatttata tcctgaatat atgggaactt ctgtgtttgg gatgtcctac     9963

tgtaagactg atgaatgtac agagttaatt tcagggtaca gttttgcctt aatggtttta    10023

aaaaataaac tattttttaa aatttt                                         10049


<210>  26
<211>  468
<212>  PRT
<213>  homo sapiens

<400>  26

Met Val Asp Thr Glu Ser Pro Leu Cys Pro Leu Ser Pro Leu Glu Ala 
1               5                   10                  15      


Gly Asp Leu Glu Ser Pro Leu Ser Glu Glu Phe Leu Gln Glu Met Gly 
            20                  25                  30          


Asn Ile Gln Glu Ile Ser Gln Ser Ile Gly Glu Asp Ser Ser Gly Ser 
        35                  40                  45              


Phe Gly Phe Thr Glu Tyr Gln Tyr Leu Gly Ser Cys Pro Gly Ser Asp 
    50                  55                  60                  


Gly Ser Val Ile Thr Asp Thr Leu Ser Pro Ala Ser Ser Pro Ser Ser 
65                  70                  75                  80  


Val Thr Tyr Pro Val Val Pro Gly Ser Val Asp Glu Ser Pro Ser Gly 
                85                  90                  95      


Ala Leu Asn Ile Glu Cys Arg Ile Cys Gly Asp Lys Ala Ser Gly Tyr 
            100                 105                 110         


His Tyr Gly Val His Ala Cys Glu Gly Cys Lys Gly Phe Phe Arg Arg 
        115                 120                 125             


Thr Ile Arg Leu Lys Leu Val Tyr Asp Lys Cys Asp Arg Ser Cys Lys 
    130                 135                 140                 


Ile Gln Lys Lys Asn Arg Asn Lys Cys Gln Tyr Cys Arg Phe His Lys 
145                 150                 155                 160 


Cys Leu Ser Val Gly Met Ser His Asn Ala Ile Arg Phe Gly Arg Met 
                165                 170                 175     


Pro Arg Ser Glu Lys Ala Lys Leu Lys Ala Glu Ile Leu Thr Cys Glu 
            180                 185                 190         


His Asp Ile Glu Asp Ser Glu Thr Ala Asp Leu Lys Ser Leu Ala Lys 
        195                 200                 205             


Arg Ile Tyr Glu Ala Tyr Leu Lys Asn Phe Asn Met Asn Lys Val Lys 
    210                 215                 220                 


Ala Arg Val Ile Leu Ser Gly Lys Ala Ser Asn Asn Pro Pro Phe Val 
225                 230                 235                 240 


Ile His Asp Met Glu Thr Leu Cys Met Ala Glu Lys Thr Leu Val Ala 
                245                 250                 255     


Lys Leu Val Ala Asn Gly Ile Gln Asn Lys Glu Ala Glu Val Arg Ile 
            260                 265                 270         


Phe His Cys Cys Gln Cys Thr Ser Val Glu Thr Val Thr Glu Leu Thr 
        275                 280                 285             


Glu Phe Ala Lys Ala Ile Pro Gly Phe Ala Asn Leu Asp Leu Asn Asp 
    290                 295                 300                 


Gln Val Thr Leu Leu Lys Tyr Gly Val Tyr Glu Ala Ile Phe Ala Met 
305                 310                 315                 320 


Leu Ser Ser Val Met Asn Lys Asp Gly Met Leu Val Ala Tyr Gly Asn 
                325                 330                 335     


Gly Phe Ile Thr Arg Glu Phe Leu Lys Ser Leu Arg Lys Pro Phe Cys 
            340                 345                 350         


Asp Ile Met Glu Pro Lys Phe Asp Phe Ala Met Lys Phe Asn Ala Leu 
        355                 360                 365             


Glu Leu Asp Asp Ser Asp Ile Ser Leu Phe Val Ala Ala Ile Ile Cys 
    370                 375                 380                 


Cys Gly Asp Arg Pro Gly Leu Leu Asn Val Gly His Ile Glu Lys Met 
385                 390                 395                 400 


Gln Glu Gly Ile Val His Val Leu Arg Leu His Leu Gln Ser Asn His 
                405                 410                 415     


Pro Asp Asp Ile Phe Leu Phe Pro Lys Leu Leu Gln Lys Met Ala Asp 
            420                 425                 430         


Leu Arg Gln Leu Val Thr Glu His Ala Gln Leu Val Gln Ile Ile Lys 
        435                 440                 445             


Lys Thr Glu Ser Asp Ala Ala Leu His Pro Leu Leu Gln Glu Ile Tyr 
    450                 455                 460                 


Arg Asp Met Tyr 
465             


<210>  27
<211>  2749
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (190)..(1854)

<400>  27
gagggctggc cagtgaggct cggcccgggg aaagtgaaag tttgcctggg tcctctcggc       60

gccagagccg ctctccgcat cccaggacag cggtgcggcc ctcggccggg gcgcccactc      120

cgcagcagcc agcgagcgag cgagcgagcg agggcggccg acgcgcccgg ccgggaccca      180

gctgcccgt atg acc gcg ccg ggc gcc gcc ggg cgc tgc cct ccc acg aca      231
          Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr         
          1               5                   10                          

tgg ctg ggc tcc ctg ctg ttg ttg gtc tgt ctc ctg gcg agc agg agt        279
Trp Leu Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser           
15                  20                  25                  30            

atc acc gag gag gtg tcg gag tac tgt agc cac atg att ggg agt gga        327
Ile Thr Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly           
                35                  40                  45                

cac ctg cag tct ctg cag cgg ctg att gac agt cag atg gag acc tcg        375
His Leu Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser           
            50                  55                  60                    

tgc caa att aca ttt gag ttt gta gac cag gaa cag ttg aaa gat cca        423
Cys Gln Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro           
        65                  70                  75                        

gtg tgc tac ctt aag aag gca ttt ctc ctg gta caa gac ata atg gag        471
Val Cys Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu           
    80                  85                  90                            

gac acc atg cgc ttc aga gat aac acc ccc aat gcc atc gcc att gtg        519
Asp Thr Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val           
95                  100                 105                 110           

cag ctg cag gaa ctc tct ttg agg ctg aag agc tgc ttc acc aag gat        567
Gln Leu Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp           
                115                 120                 125               

tat gaa gag cat gac aag gcc tgc gtc cga act ttc tat gag aca cct        615
Tyr Glu Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro           
            130                 135                 140                   

ctc cag ttg ctg gag aag gtc aag aat gtc ttt aat gaa aca aag aat        663
Leu Gln Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn           
        145                 150                 155                       

ctc ctt gac aag gac tgg aat att ttc agc aag aac tgc aac aac agc        711
Leu Leu Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser           
    160                 165                 170                           

ttt gct gaa tgc tcc agc caa gat gtg gtg acc aag cct gat tgc aac        759
Phe Ala Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn           
175                 180                 185                 190           

tgc ctg tac ccc aaa gcc atc cct agc agt gac ccg gcc tct gtc tcc        807
Cys Leu Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser           
                195                 200                 205               

cct cat cag ccc ctc gcc ccc tcc atg gcc cct gtg gct ggc ttg acc        855
Pro His Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr           
            210                 215                 220                   

tgg gag gac tct gag gga act gag ggc agc tcc ctc ttg cct ggt gag        903
Trp Glu Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu           
        225                 230                 235                       

cag ccc ctg cac aca gtg gat cca ggc agt gcc aag cag cgg cca ccc        951
Gln Pro Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro           
    240                 245                 250                           

agg agc acc tgc cag agc ttt gag ccg cca gag acc cca gtt gtc aag        999
Arg Ser Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys           
255                 260                 265                 270           

gac agc acc atc ggt ggc tca cca cag cct cgc ccc tct gtc ggg gcc       1047
Asp Ser Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala           
                275                 280                 285               

ttc aac ccc ggg atg gag gat att ctt gac tct gca atg ggc act aat       1095
Phe Asn Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn           
            290                 295                 300                   

tgg gtc cca gaa gaa gcc tct gga gag gcc agt gag att ccc gta ccc       1143
Trp Val Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro           
        305                 310                 315                       

caa ggg aca gag ctt tcc ccc tcc agg cca gga ggg ggc agc atg cag       1191
Gln Gly Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln           
    320                 325                 330                           

aca gag ccc gcc aga ccc agc aac ttc ctc tca gca tct tct cca ctc       1239
Thr Glu Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu           
335                 340                 345                 350           

cct gca tca gca aag ggc caa cag ccg gca gat gta act ggt aca gcc       1287
Pro Ala Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala           
                355                 360                 365               

ttg ccc agg gtg ggc ccc gtg agg ccc act ggc cag gac tgg aat cac       1335
Leu Pro Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His           
            370                 375                 380                   

acc ccc cag aag aca gac cat cca tct gcc ctg ctc aga gac ccc ccg       1383
Thr Pro Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro           
        385                 390                 395                       

gag cca ggc tct ccc agg atc tca tca ctg cgc ccc cag ggc ctc agc       1431
Glu Pro Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser           
    400                 405                 410                           

aac ccc tcc acc ctc tct gct cag cca cag ctt tcc aga agc cac tcc       1479
Asn Pro Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser           
415                 420                 425                 430           

tcg ggc agc gtg ctg ccc ctt ggg gag ctg gag ggc agg agg agc acc       1527
Ser Gly Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr           
                435                 440                 445               

agg gat cgg agg agc ccc gca gag cca gaa gga gga cca gca agt gaa       1575
Arg Asp Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu           
            450                 455                 460                   

ggg gca gcc agg ccc ctg ccc cgt ttt aac tcc gtt cct ttg act gac       1623
Gly Ala Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp           
        465                 470                 475                       

aca ggc cat gag agg cag tcc gag gga tcc tcc agc ccg cag ctc cag       1671
Thr Gly His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln           
    480                 485                 490                           

gag tct gtc ttc cac ctg ctg gtg ccc agt gtc atc ctg gtc ttg ctg       1719
Glu Ser Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu           
495                 500                 505                 510           

gcc gtc gga ggc ctc ttg ttc tac agg tgg agg cgg cgg agc cat caa       1767
Ala Val Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln           
                515                 520                 525               

gag cct cag aga gcg gat tct ccc ttg gag caa cca gag ggc agc ccc       1815
Glu Pro Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro           
            530                 535                 540                   

ctg act cag gat gac aga cag gtg gaa ctg cca gtg tag agggaattct        1864
Leu Thr Gln Asp Asp Arg Gln Val Glu Leu Pro Val                           
        545                 550                                           

aagctggacg cacagaacag tctctccgtg ggaggagaca ttatggggcg tccaccacca     1924

cccctccctg gccatcctcc tggaatgtgg tctgccctcc accagagctc ctgcctgcca     1984

ggactggacc agagcagcca ggctggggcc cctctgtctc aacccgcaga cccttgactg     2044

aatgagagag gccagaggat gctccccatg ctgccactat ttattgtgag ccctggaggc     2104

tcccatgtgc ttgaggaagg ctggtgagcc cggctcagga ccctcttccc tcaggggctg     2164

caccctcctc tcactccctt ccatgccgga acccaggcca gggacccacc ggcctgtggt     2224

ttgtgggaaa gcagggtgga cgctgaggag tgaaagaacc ctgcacccag agggcctgcc     2284

tggtgccaag gtatcccagc ctggacaggc atggacctgt ctccagagag aggagcctga     2344

agttcgtggg gcgggacagc gtcggcctga tttcccgtaa aggtgtgcag cctgagagac     2404

gggaagagga ggcctctgga cctgctggtc tgcactgaca gcctgaaggg tctacaccct     2464

cggctcacct aagtgccctg tgctggttgc caggcgcaga ggggaggcca gccctgccct     2524

caggacctgc ctgacctgcc agtgatgcca agagggggat caagcactgg cctctgcccc     2584

tcctccttcc agcacctgcc agagcttctc caggaggcca agcagaggct cccctcatga     2644

aggaagccat tgcactgtga acactgtacc tgcctgctga acagcctgcc cccgtccatc     2704

catgagccag catccgtccg tcctccactc tccagcctct cccca                     2749


<210>  28
<211>  554
<212>  PRT
<213>  homo sapiens

<400>  28

Met Thr Ala Pro Gly Ala Ala Gly Arg Cys Pro Pro Thr Thr Trp Leu 
1               5                   10                  15      


Gly Ser Leu Leu Leu Leu Val Cys Leu Leu Ala Ser Arg Ser Ile Thr 
            20                  25                  30          


Glu Glu Val Ser Glu Tyr Cys Ser His Met Ile Gly Ser Gly His Leu 
        35                  40                  45              


Gln Ser Leu Gln Arg Leu Ile Asp Ser Gln Met Glu Thr Ser Cys Gln 
    50                  55                  60                  


Ile Thr Phe Glu Phe Val Asp Gln Glu Gln Leu Lys Asp Pro Val Cys 
65                  70                  75                  80  


Tyr Leu Lys Lys Ala Phe Leu Leu Val Gln Asp Ile Met Glu Asp Thr 
                85                  90                  95      


Met Arg Phe Arg Asp Asn Thr Pro Asn Ala Ile Ala Ile Val Gln Leu 
            100                 105                 110         


Gln Glu Leu Ser Leu Arg Leu Lys Ser Cys Phe Thr Lys Asp Tyr Glu 
        115                 120                 125             


Glu His Asp Lys Ala Cys Val Arg Thr Phe Tyr Glu Thr Pro Leu Gln 
    130                 135                 140                 


Leu Leu Glu Lys Val Lys Asn Val Phe Asn Glu Thr Lys Asn Leu Leu 
145                 150                 155                 160 


Asp Lys Asp Trp Asn Ile Phe Ser Lys Asn Cys Asn Asn Ser Phe Ala 
                165                 170                 175     


Glu Cys Ser Ser Gln Asp Val Val Thr Lys Pro Asp Cys Asn Cys Leu 
            180                 185                 190         


Tyr Pro Lys Ala Ile Pro Ser Ser Asp Pro Ala Ser Val Ser Pro His 
        195                 200                 205             


Gln Pro Leu Ala Pro Ser Met Ala Pro Val Ala Gly Leu Thr Trp Glu 
    210                 215                 220                 


Asp Ser Glu Gly Thr Glu Gly Ser Ser Leu Leu Pro Gly Glu Gln Pro 
225                 230                 235                 240 


Leu His Thr Val Asp Pro Gly Ser Ala Lys Gln Arg Pro Pro Arg Ser 
                245                 250                 255     


Thr Cys Gln Ser Phe Glu Pro Pro Glu Thr Pro Val Val Lys Asp Ser 
            260                 265                 270         


Thr Ile Gly Gly Ser Pro Gln Pro Arg Pro Ser Val Gly Ala Phe Asn 
        275                 280                 285             


Pro Gly Met Glu Asp Ile Leu Asp Ser Ala Met Gly Thr Asn Trp Val 
    290                 295                 300                 


Pro Glu Glu Ala Ser Gly Glu Ala Ser Glu Ile Pro Val Pro Gln Gly 
305                 310                 315                 320 


Thr Glu Leu Ser Pro Ser Arg Pro Gly Gly Gly Ser Met Gln Thr Glu 
                325                 330                 335     


Pro Ala Arg Pro Ser Asn Phe Leu Ser Ala Ser Ser Pro Leu Pro Ala 
            340                 345                 350         


Ser Ala Lys Gly Gln Gln Pro Ala Asp Val Thr Gly Thr Ala Leu Pro 
        355                 360                 365             


Arg Val Gly Pro Val Arg Pro Thr Gly Gln Asp Trp Asn His Thr Pro 
    370                 375                 380                 


Gln Lys Thr Asp His Pro Ser Ala Leu Leu Arg Asp Pro Pro Glu Pro 
385                 390                 395                 400 


Gly Ser Pro Arg Ile Ser Ser Leu Arg Pro Gln Gly Leu Ser Asn Pro 
                405                 410                 415     


Ser Thr Leu Ser Ala Gln Pro Gln Leu Ser Arg Ser His Ser Ser Gly 
            420                 425                 430         


Ser Val Leu Pro Leu Gly Glu Leu Glu Gly Arg Arg Ser Thr Arg Asp 
        435                 440                 445             


Arg Arg Ser Pro Ala Glu Pro Glu Gly Gly Pro Ala Ser Glu Gly Ala 
    450                 455                 460                 


Ala Arg Pro Leu Pro Arg Phe Asn Ser Val Pro Leu Thr Asp Thr Gly 
465                 470                 475                 480 


His Glu Arg Gln Ser Glu Gly Ser Ser Ser Pro Gln Leu Gln Glu Ser 
                485                 490                 495     


Val Phe His Leu Leu Val Pro Ser Val Ile Leu Val Leu Leu Ala Val 
            500                 505                 510         


Gly Gly Leu Leu Phe Tyr Arg Trp Arg Arg Arg Ser His Gln Glu Pro 
        515                 520                 525             


Gln Arg Ala Asp Ser Pro Leu Glu Gln Pro Glu Gly Ser Pro Leu Thr 
    530                 535                 540                 


Gln Asp Asp Arg Gln Val Glu Leu Pro Val 
545                 550                 


<210>  29
<211>  1325
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (145)..(1032)

<400>  29
gcagtagcag cgagcagcag agtccgcacg ctccggcgag gggcagaaga gcgcgaggga       60

gcgcggggca gcagaagcga gagccgagcg cggacccagc caggacccac agccctcccc      120

agctgcccag gaagagcccc agcc atg gaa cac cag ctc ctg tgc tgc gaa         171
                           Met Glu His Gln Leu Leu Cys Cys Glu            
                           1               5                              

gtg gaa acc atc cgc cgc gcg tac ccc gat gcc aac ctc ctc aac gac        219
Val Glu Thr Ile Arg Arg Ala Tyr Pro Asp Ala Asn Leu Leu Asn Asp           
10                  15                  20                  25            

cgg gtg ctg cgg gcc atg ctg aag gcg gag gag acc tgc gcg ccc tcg        267
Arg Val Leu Arg Ala Met Leu Lys Ala Glu Glu Thr Cys Ala Pro Ser           
                30                  35                  40                

gtg tcc tac ttc aaa tgt gtg cag aag gag gtc ctg ccg tcc atg cgg        315
Val Ser Tyr Phe Lys Cys Val Gln Lys Glu Val Leu Pro Ser Met Arg           
            45                  50                  55                    

aag atc gtc gcc acc tgg atg ctg gag gtc tgc gag gaa cag aag tgc        363
Lys Ile Val Ala Thr Trp Met Leu Glu Val Cys Glu Glu Gln Lys Cys           
        60                  65                  70                        

gag gag gag gtc ttc ccg ctg gcc atg aac tac ctg gac cgc ttc ctg        411
Glu Glu Glu Val Phe Pro Leu Ala Met Asn Tyr Leu Asp Arg Phe Leu           
    75                  80                  85                            

tcg ctg gag ccc gtg aaa aag agc cgc ctg cag ctg ctg ggg gcc act        459
Ser Leu Glu Pro Val Lys Lys Ser Arg Leu Gln Leu Leu Gly Ala Thr           
90                  95                  100                 105           

tgc atg ttc gtg gcc tct aag atg aag gag acc atc ccc ctg acg gcc        507
Cys Met Phe Val Ala Ser Lys Met Lys Glu Thr Ile Pro Leu Thr Ala           
                110                 115                 120               

gag aag ctg tgc atc tac acc gac ggc tcc atc cgg ccc gag gag ctg        555
Glu Lys Leu Cys Ile Tyr Thr Asp Gly Ser Ile Arg Pro Glu Glu Leu           
            125                 130                 135                   

ctg caa atg gag ctg ctc ctg gtg aac aag ctc aag tgg aac ctg gcc        603
Leu Gln Met Glu Leu Leu Leu Val Asn Lys Leu Lys Trp Asn Leu Ala           
        140                 145                 150                       

gca atg acc ccg cac gat ttc att gaa cac ttc ctc tcc aaa atg cca        651
Ala Met Thr Pro His Asp Phe Ile Glu His Phe Leu Ser Lys Met Pro           
    155                 160                 165                           

gag gcg gag gag aac aaa cag atc atc cgc aaa cac gcg cag acc ttc        699
Glu Ala Glu Glu Asn Lys Gln Ile Ile Arg Lys His Ala Gln Thr Phe           
170                 175                 180                 185           

gtt gcc tct tgt gcc aca gat gtg aag ttc att tcc aat ccg ccc tcc        747
Val Ala Ser Cys Ala Thr Asp Val Lys Phe Ile Ser Asn Pro Pro Ser           
                190                 195                 200               

atg gtg gca gcg ggg agc gtg gtg gcc gca gtg caa ggc ctg aac ctg        795
Met Val Ala Ala Gly Ser Val Val Ala Ala Val Gln Gly Leu Asn Leu           
            205                 210                 215                   

agg agc ccc aac aac ttc ctg tcc tac tac cgc ctc aca cgc ttc ctc        843
Arg Ser Pro Asn Asn Phe Leu Ser Tyr Tyr Arg Leu Thr Arg Phe Leu           
        220                 225                 230                       

tcc aga gtg atc aag tgt gac cca gac tgc ctc cgg gcc tgc cag gag        891
Ser Arg Val Ile Lys Cys Asp Pro Asp Cys Leu Arg Ala Cys Gln Glu           
    235                 240                 245                           

cag atc gaa gcc ctg ctg gag tca agc ctg cgc cag gcc cag cag aac        939
Gln Ile Glu Ala Leu Leu Glu Ser Ser Leu Arg Gln Ala Gln Gln Asn           
250                 255                 260                 265           

atg gac ccc aag gcc gcc gag gag gag gaa gag gag gag gag gag gtg        987
Met Asp Pro Lys Ala Ala Glu Glu Glu Glu Glu Glu Glu Glu Glu Val           
                270                 275                 280               

gac ctg gct tgc aca ccc acc gac gtg cgg gac gtg gac atc tga           1032
Asp Leu Ala Cys Thr Pro Thr Asp Val Arg Asp Val Asp Ile                   
            285                 290                 295                   

ggggcccagg caggcgggcg ccaccgccac ccgcagcgag ggcggagccg gccccaggtg     1092

ctccacatga cagtccctcc tctccggagc attttgatac cagaagggaa agcttcattc     1152

tccttgttgt tggttgtttt ttcctttgct ctttccccct tccatctctg acttaagcaa     1212

aagaaaaaga ttacccaaaa actgtcttta aaagagagag agagaaaaaa aaaaaaaaaa     1272

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa            1325


<210>  30
<211>  295
<212>  PRT
<213>  homo sapiens

<400>  30

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
    50                  55                  60                  


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
65                  70                  75                  80  


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
                85                  90                  95      


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
            100                 105                 110         


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
        115                 120                 125             


Asp Gly Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu Leu 
    130                 135                 140                 


Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp Phe 
145                 150                 155                 160 


Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys Gln 
                165                 170                 175     


Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Ser Cys Ala Thr Asp 
            180                 185                 190         


Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val Ala Ala Gly Ser Val 
        195                 200                 205             


Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser Pro Asn Asn Phe Leu 
    210                 215                 220                 


Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg Val Ile Lys Cys Asp 
225                 230                 235                 240 


Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile Glu Ala Leu Leu Glu 
                245                 250                 255     


Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp Pro Lys Ala Ala Glu 
            260                 265                 270         


Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu Ala Cys Thr Pro Thr 
        275                 280                 285             


Asp Val Arg Asp Val Asp Ile 
    290                 295 


<210>  31
<211>  716
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (224)..(592)

<400>  31
aggctcagta taaatagcag ccaccgctcc ctggcaggca gggacccgca gctcagctac       60

agcacagatc aggtgaggag cacaccaagg agtgattttt aaaacttact ctgttttctc      120

tttcccaaca agattatcat ttcctttaaa aaaaatagtt atcctggggc atacagccat      180

accattctga aggtgtctta tctcctctga tctagagagc acc atg aag ctt ctc        235
                                                Met Lys Leu Leu           
                                                1                         

acg ggc ctg gtt ttc tgc tcc ttg gtc ctg ggt gtc agc agc cga agc        283
Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val Ser Ser Arg Ser           
5                   10                  15                  20            

ttc ttt tcg ttc ctt ggc gag gct ttt gat ggg gct cgg gac atg tgg        331
Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp Met Trp           
                25                  30                  35                

aga gcc tac tct gac atg aga gaa gcc aat tac atc ggc tca gac aaa        379
Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser Asp Lys           
            40                  45                  50                    

tac ttc cat gct cgg ggg aac tat gat gct gcc aaa agg gga cct ggg        427
Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly Pro Gly           
        55                  60                  65                        

ggt gcc tgg gct gca gaa gtg atc agc gat gcc aga gag aat atc cag        475
Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg Glu Asn Ile Gln           
    70                  75                  80                            

aga ttc ttt ggc cat ggt gcg gag gac tcg ctg gct gat cag gct gcc        523
Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala Asp Gln Ala Ala           
85                  90                  95                  100           

aat gaa tgg ggc agg agt ggc aaa gac ccc aat cac ttc cga cct gct        571
Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg Pro Ala           
                105                 110                 115               

ggc ctg cct gag aaa tac tga gcttcctctt cactctgctc tcaggagatc           622
Gly Leu Pro Glu Lys Tyr                                                   
            120                                                           

tggctgtgag gccctcaggg cagggataca aagcggggag agggtacaca atgggtatct      682

aataaatact taagaggtgg aatttgtgga aact                                  716


<210>  32
<211>  122
<212>  PRT
<213>  homo sapiens

<400>  32

Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 
1               5                   10                  15      


Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 
            20                  25                  30          


Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 
        35                  40                  45              


Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 
    50                  55                  60                  


Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 
65                  70                  75                  80  


Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 
                85                  90                  95      


Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 
            100                 105                 110         


Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 
        115                 120         


<210>  33
<211>  1887
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (250)..(540)

<400>  33
ctttttaagc tcccctgagc cggtgctgcg ctcctctaat tgggactccg agccggggct       60

atttctggcg ctggcgcggc tccaagaagg catccgcatt tgctaccagc ggcggccgcg      120

gcggagccag gccggtcctc agcgcccagc accgccgctc ccggcaaccc ggagcgcgca      180

ccgcaggccg gcggccgagc tcgcgcatcc cagccatcac tcttccacct gctccttaga      240

gaagggaag atg agt gag tcg agc tcg aag tcc agc cag ccc ttg gcc tcc      291
          Met Ser Glu Ser Ser Ser Lys Ser Ser Gln Pro Leu Ala Ser         
          1               5                   10                          

aag cag gaa aag gac ggc act gag aag cgg ggc cgg ggc agg ccg cgc        339
Lys Gln Glu Lys Asp Gly Thr Glu Lys Arg Gly Arg Gly Arg Pro Arg           
15                  20                  25                  30            

aag cag cct ccg aag gag ccc agc gaa gtg cca aca cct aag aga cct        387
Lys Gln Pro Pro Lys Glu Pro Ser Glu Val Pro Thr Pro Lys Arg Pro           
                35                  40                  45                

cgg ggc cga cca aag gga agc aaa aac aag ggt gct gcc aag acc cgg        435
Arg Gly Arg Pro Lys Gly Ser Lys Asn Lys Gly Ala Ala Lys Thr Arg           
            50                  55                  60                    

aaa acc acc aca act cca gga agg aaa cca agg ggc aga ccc aaa aaa        483
Lys Thr Thr Thr Thr Pro Gly Arg Lys Pro Arg Gly Arg Pro Lys Lys           
        65                  70                  75                        

ctg gag aag gag gaa gag gag ggc atc tcg cag gag tcc tcg gag gag        531
Leu Glu Lys Glu Glu Glu Glu Gly Ile Ser Gln Glu Ser Ser Glu Glu           
    80                  85                  90                            

gag cag tga cccatgcgtg ccgcctgctc ctcactggag gagcagcttc                580
Glu Gln                                                                   
95                                                                        

cttctgggac tggacagctt tgctccgctc ccaccgcccc cgccccttcc ccaggcccac      640

catcaccacc gcctctggcc gccaccccca tcttccacct gtgccctcac caccacacta      700

cacagcacac cagccgctgc agggctccca tgggctgagt ggggagcagt tttcccctgg      760

cctcagttcc cagctccccc cgcccaccca cgcatacaca catgccctcc tggacaaggc      820

taacatccca cttagccgca ccctgcacct gctgcgtccc cactcccttg gtggtgggga      880

cattgctctc tgggcttttg gtttgggggc gccctctctg ctccttcact gttccctctg      940

gcttcccata gtggggcctg ggagggttcc cctggcctta aaaggggccc aagccccatc     1000

tcatcctggc acgccctact ccactgccct ggcagcagca ggtgtggcca atggaggggg     1060

gtgctggccc ccaggattcc cccagccaaa ctgtctttgt caccacgtgg ggctcacttt     1120

tcatccttcc ccaacttccc tagtccccgt actaggttgg acagccccct tcggctacag     1180

gaaggcagga ggggtgagtc ccctactccc tcttcactgt ggccacagcc cccttgccct     1240

ccgcctggga tctgagtaca tattgtggtg atggagatgc agtcacttat tgtccaggtg     1300

aggcccaaga gccctgtggc cgccacctga ggtgggctgg ggctgctccc ctaaccctac     1360

tttgcttccg ccactcagcc atttccccct cctcagatgg ggcaccaata acaaggagct     1420

caccctgccc gctcccaacc cccctcctgc tcctccctgc cccccaaggt tctggttcca     1480

tttttcctct gttcacaaac tacctctgga cagttgtgtt gttttttgtt caatgttcca     1540

ttcttcgaca tccgtcattg ctgctgctac cagcgccaaa tgttcatcct cattgcctcc     1600

tgttctgccc acgatcccct cccccaagat actctttgtg gggaagaggg gctggggcat     1660

ggcaggctgg gtgaccgact accccagtcc cagggaaggt ggggccctgc ccctaggatg     1720

ctgcagcaga gtgagcaagg gggcccgaat cgaccataaa gggtgtaggg gccacctcct     1780

ccccctgttc tgttggggag gggtagccat gatttgtccc agcctggggc tccctctctg     1840

gtttcctatt tgcagttact tgaataaaaa aaatatcctt ttctgga                   1887


<210>  34
<211>  96
<212>  PRT
<213>  homo sapiens

<400>  34

Met Ser Glu Ser Ser Ser Lys Ser Ser Gln Pro Leu Ala Ser Lys Gln 
1               5                   10                  15      


Glu Lys Asp Gly Thr Glu Lys Arg Gly Arg Gly Arg Pro Arg Lys Gln 
            20                  25                  30          


Pro Pro Lys Glu Pro Ser Glu Val Pro Thr Pro Lys Arg Pro Arg Gly 
        35                  40                  45              


Arg Pro Lys Gly Ser Lys Asn Lys Gly Ala Ala Lys Thr Arg Lys Thr 
    50                  55                  60                  


Thr Thr Thr Pro Gly Arg Lys Pro Arg Gly Arg Pro Lys Lys Leu Glu 
65                  70                  75                  80  


Lys Glu Glu Glu Glu Gly Ile Ser Gln Glu Ser Ser Glu Glu Glu Gln 
                85                  90                  95      


<210>  35
<211>  627
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (96)..(335)

<400>  35
agtctccggc gagttgttgc ctgggctgga cgtggttttg tctgctgcgc ccgctcttcg       60

cgctctcgtt tcattttctg cagcgcgcca cgagg atg gcc cac aag cag atc         113
                                       Met Ala His Lys Gln Ile            
                                       1               5                  

tac tac tcg gac aag tac ttc gac gaa cac tac gag tac cgg cat gtt        161
Tyr Tyr Ser Asp Lys Tyr Phe Asp Glu His Tyr Glu Tyr Arg His Val           
            10                  15                  20                    

atg tta ccc aga gaa ctt tcc aaa caa gta cct aaa act cat ctg atg        209
Met Leu Pro Arg Glu Leu Ser Lys Gln Val Pro Lys Thr His Leu Met           
        25                  30                  35                        

tct gaa gag gag tgg agg aga ctt ggt gtc caa cag agt cta ggc tgg        257
Ser Glu Glu Glu Trp Arg Arg Leu Gly Val Gln Gln Ser Leu Gly Trp           
    40                  45                  50                            

gtt cat tac atg att cat gag cca gaa cca cat att ctt ctc ttt aga        305
Val His Tyr Met Ile His Glu Pro Glu Pro His Ile Leu Leu Phe Arg           
55                  60                  65                  70            

cga cct ctt cca aaa gat caa caa aaa tga agtttatctg gggatcgtca          355
Arg Pro Leu Pro Lys Asp Gln Gln Lys                                       
                75                                                        

aatctttttc aaatttaatg tatatgtgta tataaggtag tattcagtga atacttgaga      415

aatgtacaaa tctttcatcc atacctgtgc atgagctgta ttcttcacag caacagagct      475

cagttaaatg caactgcaag taggttactg taagatgttt aagataaaag ttcttccagt      535

cagtttttct cttaagtgcc tgtttgagtt tactgaaaca gtttactttt gttcaataaa      595

gtttgtatgt tgcatttaaa aaaaaaaaaa aa                                    627


<210>  36
<211>  79
<212>  PRT
<213>  homo sapiens

<400>  36

Met Ala His Lys Gln Ile Tyr Tyr Ser Asp Lys Tyr Phe Asp Glu His 
1               5                   10                  15      


Tyr Glu Tyr Arg His Val Met Leu Pro Arg Glu Leu Ser Lys Gln Val 
            20                  25                  30          


Pro Lys Thr His Leu Met Ser Glu Glu Glu Trp Arg Arg Leu Gly Val 
        35                  40                  45              


Gln Gln Ser Leu Gly Trp Val His Tyr Met Ile His Glu Pro Glu Pro 
    50                  55                  60                  


His Ile Leu Leu Phe Arg Arg Pro Leu Pro Lys Asp Gln Gln Lys 
65                  70                  75                  


<210>  37
<211>  3480
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (268)..(2925)

<400>  37
ggcggagatc gcgtctcttt cgctccgtgt ccgctgctgc tcctgtgagc gcccggcgag       60

tccgtcccgt ccaccgtccg cagctggtag ccagcctgcc cctcgcctcg actccctttc      120

accaacaccg acacccacat tgacacctcc agtccggcca gccgctccac tcgttgcctt      180

tgcatctcca cacatggcgt cctcgcgcag agcggcggct cctccggggg acccgcggtc      240

cccaccgtgc agcggggcat catcaag atg gtc ctc tca ggg tgc gcc atc att      294
                              Met Val Leu Ser Gly Cys Ala Ile Ile         
                              1               5                           

gtc cga ggt cag cct cgt ggt ggg cct cct cct gag cgg cag atc aac        342
Val Arg Gly Gln Pro Arg Gly Gly Pro Pro Pro Glu Arg Gln Ile Asn           
10                  15                  20                  25            

ctc agc aac att cgt gct gga aat ctt gct cgc cgg gca gcc gcc aca        390
Leu Ser Asn Ile Arg Ala Gly Asn Leu Ala Arg Arg Ala Ala Ala Thr           
                30                  35                  40                

caa cct gat gca aag gat acc cct gat gag ccc tgg gca ttt cca gct        438
Gln Pro Asp Ala Lys Asp Thr Pro Asp Glu Pro Trp Ala Phe Pro Ala           
            45                  50                  55                    

cga gag ttc ctt cga aag aag ctg att ggg aag gaa gtc tgt ttc acg        486
Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Glu Val Cys Phe Thr           
        60                  65                  70                        

ata gaa aac aag act ccc cag ggg cga gag tat ggc atg atc tac ctt        534
Ile Glu Asn Lys Thr Pro Gln Gly Arg Glu Tyr Gly Met Ile Tyr Leu           
    75                  80                  85                            

gga aaa gat acc aat ggg gaa aac att gca gaa tca ctg gtt gca gag        582
Gly Lys Asp Thr Asn Gly Glu Asn Ile Ala Glu Ser Leu Val Ala Glu           
90                  95                  100                 105           

ggc tta gcc acc cgg aga gaa ggc atg aga gct aat aat cct gag cag        630
Gly Leu Ala Thr Arg Arg Glu Gly Met Arg Ala Asn Asn Pro Glu Gln           
                110                 115                 120               

aac cgg ctt tca gaa tgt gaa gaa caa gca aag gca gcc aag aaa ggg        678
Asn Arg Leu Ser Glu Cys Glu Glu Gln Ala Lys Ala Ala Lys Lys Gly           
            125                 130                 135                   

atg tgg agt gag ggg aac ggt tca cat act atc cgg gat ctc aag tat        726
Met Trp Ser Glu Gly Asn Gly Ser His Thr Ile Arg Asp Leu Lys Tyr           
        140                 145                 150                       

acc att gaa aac cca agg cac ttt gtg gac tca cac cac cag aag cct        774
Thr Ile Glu Asn Pro Arg His Phe Val Asp Ser His His Gln Lys Pro           
    155                 160                 165                           

gtt aat gct atc atc gag cat gtg cgg gac ggc agt gtg gtc agg gcc        822
Val Asn Ala Ile Ile Glu His Val Arg Asp Gly Ser Val Val Arg Ala           
170                 175                 180                 185           

ctg ctc ctc cca gat tac tac ctg gtt aca gtc atg ctg tca ggc atc        870
Leu Leu Leu Pro Asp Tyr Tyr Leu Val Thr Val Met Leu Ser Gly Ile           
                190                 195                 200               

aag tgc cca act ttt cga cgg gaa gca gat ggc agt gaa act cca gag        918
Lys Cys Pro Thr Phe Arg Arg Glu Ala Asp Gly Ser Glu Thr Pro Glu           
            205                 210                 215                   

cct ttt gct gca gaa gcc aaa ttt ttc act gag tcg cga ctg ctt cag        966
Pro Phe Ala Ala Glu Ala Lys Phe Phe Thr Glu Ser Arg Leu Leu Gln           
        220                 225                 230                       

aga gat gtt cag atc att ctg gag agc tgc cac aac cag aac att gtg       1014
Arg Asp Val Gln Ile Ile Leu Glu Ser Cys His Asn Gln Asn Ile Val           
    235                 240                 245                           

ggt acc atc ctt cat cca aat ggc aac atc aca gag ctc ctc ctg aag       1062
Gly Thr Ile Leu His Pro Asn Gly Asn Ile Thr Glu Leu Leu Leu Lys           
250                 255                 260                 265           

gaa ggt ttc gca cgc tgt gtg gac tgg tcg att gca gtt tac acc cgg       1110
Glu Gly Phe Ala Arg Cys Val Asp Trp Ser Ile Ala Val Tyr Thr Arg           
                270                 275                 280               

ggc gca gaa aag ctg agg gcg gca gag agg ttt gcc aaa gag cgc agg       1158
Gly Ala Glu Lys Leu Arg Ala Ala Glu Arg Phe Ala Lys Glu Arg Arg           
            285                 290                 295                   

ctg aga ata tgg aga gac tat gtg gct ccc aca gct aat ttg gac caa       1206
Leu Arg Ile Trp Arg Asp Tyr Val Ala Pro Thr Ala Asn Leu Asp Gln           
        300                 305                 310                       

aag gac aag cag ttt gtt gcc aag gtg atg cag gtt ctg aat gct gat       1254
Lys Asp Lys Gln Phe Val Ala Lys Val Met Gln Val Leu Asn Ala Asp           
    315                 320                 325                           

gcc att gtt gtg aag ctg aac tca ggc gat tac aag acg att cac ctg       1302
Ala Ile Val Val Lys Leu Asn Ser Gly Asp Tyr Lys Thr Ile His Leu           
330                 335                 340                 345           

tcc agc atc cga cca ccg agg ctg gag ggg gag aac acc cag gat aag       1350
Ser Ser Ile Arg Pro Pro Arg Leu Glu Gly Glu Asn Thr Gln Asp Lys           
                350                 355                 360               

aac aag aaa ctg cgt ccc ctg tat gac att cct tac atg ttt gag gcc       1398
Asn Lys Lys Leu Arg Pro Leu Tyr Asp Ile Pro Tyr Met Phe Glu Ala           
            365                 370                 375                   

cgg gaa ttt ctt cga aaa aag ctt att ggg aag aag gtc aat gtg acg       1446
Arg Glu Phe Leu Arg Lys Lys Leu Ile Gly Lys Lys Val Asn Val Thr           
        380                 385                 390                       

gtg gac tac att aga cca gcc agc cca gcc aca gag aca gtg cct gcc       1494
Val Asp Tyr Ile Arg Pro Ala Ser Pro Ala Thr Glu Thr Val Pro Ala           
    395                 400                 405                           

ttt tca gag cgt acc tgt gcc act gtc acc att gga gga ata aac att       1542
Phe Ser Glu Arg Thr Cys Ala Thr Val Thr Ile Gly Gly Ile Asn Ile           
410                 415                 420                 425           

gct gag gct ctt gtc agc aaa ggt cta gcc aca gtg atc aga tac cgg       1590
Ala Glu Ala Leu Val Ser Lys Gly Leu Ala Thr Val Ile Arg Tyr Arg           
                430                 435                 440               

cag gat gat gac cag aga tca tca cac tac gat gaa ctg ctt gct gca       1638
Gln Asp Asp Asp Gln Arg Ser Ser His Tyr Asp Glu Leu Leu Ala Ala           
            445                 450                 455                   

gag gcc aga gct att aag aat ggc aaa gga ttg cat agc aag aag gaa       1686
Glu Ala Arg Ala Ile Lys Asn Gly Lys Gly Leu His Ser Lys Lys Glu           
        460                 465                 470                       

gtg cct atc cac cgt gtt gca gat ata tct ggg gat acc caa aaa gca       1734
Val Pro Ile His Arg Val Ala Asp Ile Ser Gly Asp Thr Gln Lys Ala           
    475                 480                 485                           

aag cag ttc ctg cct ttt ctt cag cgg gca ggt cgt tct gaa gct gtg       1782
Lys Gln Phe Leu Pro Phe Leu Gln Arg Ala Gly Arg Ser Glu Ala Val           
490                 495                 500                 505           

gtg gaa tac gtc ttc agt ggt tct cgt ctc aaa ctc tat ttg cca aag       1830
Val Glu Tyr Val Phe Ser Gly Ser Arg Leu Lys Leu Tyr Leu Pro Lys           
                510                 515                 520               

gaa act tgc ctt atc acc ttc ttg ctt gca ggc att gaa tgc ccc aga       1878
Glu Thr Cys Leu Ile Thr Phe Leu Leu Ala Gly Ile Glu Cys Pro Arg           
            525                 530                 535                   

gga gcc cga aac ctc cca ggc ttg gtg cag gaa gga gag ccc ttc agc       1926
Gly Ala Arg Asn Leu Pro Gly Leu Val Gln Glu Gly Glu Pro Phe Ser           
        540                 545                 550                       

gag gaa gct aca ctt ttc acc aag gaa ctg gtg ctg cag cga gag gtg       1974
Glu Glu Ala Thr Leu Phe Thr Lys Glu Leu Val Leu Gln Arg Glu Val           
    555                 560                 565                           

gag gtg gag gtg gag agc atg gac aag gcc ggc aac ttt atc ggc tgg       2022
Glu Val Glu Val Glu Ser Met Asp Lys Ala Gly Asn Phe Ile Gly Trp           
570                 575                 580                 585           

ctg cac atc gac ggt gcc aac ctg tcc gtc ctg ctg gtg gag cac gcg       2070
Leu His Ile Asp Gly Ala Asn Leu Ser Val Leu Leu Val Glu His Ala           
                590                 595                 600               

ctc tcc aag gtc cac ttc acc gcc gaa cgc agc tcc tac tac aag tcc       2118
Leu Ser Lys Val His Phe Thr Ala Glu Arg Ser Ser Tyr Tyr Lys Ser           
            605                 610                 615                   

ctg ctg tct gcc gag gag gcc gca aag cag aag aaa gag aag gtc tgg       2166
Leu Leu Ser Ala Glu Glu Ala Ala Lys Gln Lys Lys Glu Lys Val Trp           
        620                 625                 630                       

gcc cac tat gag gag cag ccc gtg gag gag gtg atg cca gtg ctg gag       2214
Ala His Tyr Glu Glu Gln Pro Val Glu Glu Val Met Pro Val Leu Glu           
    635                 640                 645                           

gag aag gag cga tct gct agc tac aag ccc gtg ttt gtg acc gag atc       2262
Glu Lys Glu Arg Ser Ala Ser Tyr Lys Pro Val Phe Val Thr Glu Ile           
650                 655                 660                 665           

act gat gac ctg cac ttc tac gtg cag gat gtg gag acc ggc acc cag       2310
Thr Asp Asp Leu His Phe Tyr Val Gln Asp Val Glu Thr Gly Thr Gln           
                670                 675                 680               

ttc cag aag ctg atg gag aac atg cgc aat gac att gcc agt cac ccc       2358
Phe Gln Lys Leu Met Glu Asn Met Arg Asn Asp Ile Ala Ser His Pro           
            685                 690                 695                   

cct gta gag ggc tcc tat gcc ccc cgc agg gga gag ttc tgc att gcc       2406
Pro Val Glu Gly Ser Tyr Ala Pro Arg Arg Gly Glu Phe Cys Ile Ala           
        700                 705                 710                       

aaa ttt gta gat gga gaa tgg tac cgt gcc cga gta gag aaa gtc gag       2454
Lys Phe Val Asp Gly Glu Trp Tyr Arg Ala Arg Val Glu Lys Val Glu           
    715                 720                 725                           

tct cct gcc aaa ata cat gtc ttc tac att gac tac ggc aac aga gag       2502
Ser Pro Ala Lys Ile His Val Phe Tyr Ile Asp Tyr Gly Asn Arg Glu           
730                 735                 740                 745           

gtc ctg cca tcc acc cgc ctg ggt acc cta tca cct gcc ttc agc act       2550
Val Leu Pro Ser Thr Arg Leu Gly Thr Leu Ser Pro Ala Phe Ser Thr           
                750                 755                 760               

cgg gtg ctg cca gct caa gcc acg gag tat gcc ttc gcc ttc atc cag       2598
Arg Val Leu Pro Ala Gln Ala Thr Glu Tyr Ala Phe Ala Phe Ile Gln           
            765                 770                 775                   

gtg ccc caa gat gat gat gcc cgc acg gac gcc gtg gac agc gta gtt       2646
Val Pro Gln Asp Asp Asp Ala Arg Thr Asp Ala Val Asp Ser Val Val           
        780                 785                 790                       

cgg gat atc cag aac act cag tgc ctg ctc aac gtg gaa cac ctg agt       2694
Arg Asp Ile Gln Asn Thr Gln Cys Leu Leu Asn Val Glu His Leu Ser           
    795                 800                 805                           

gcc ggc tgc ccc cat gtc acc ctg cag ttt gca gat tcc aag ggc gat       2742
Ala Gly Cys Pro His Val Thr Leu Gln Phe Ala Asp Ser Lys Gly Asp           
810                 815                 820                 825           

gtg ggg ctg ggc ttg gtg aag gaa ggg ctg gtc atg gtg gag gtg cgc       2790
Val Gly Leu Gly Leu Val Lys Glu Gly Leu Val Met Val Glu Val Arg           
                830                 835                 840               

aag gag aaa cag ttc cag aaa gtg atc aca gaa tac ctg aat gcc caa       2838
Lys Glu Lys Gln Phe Gln Lys Val Ile Thr Glu Tyr Leu Asn Ala Gln           
            845                 850                 855                   

gag tca gcc aag agc gcc agg ctg aac ctg tgg cgc tat gga gac ttt       2886
Glu Ser Ala Lys Ser Ala Arg Leu Asn Leu Trp Arg Tyr Gly Asp Phe           
        860                 865                 870                       

cga gct gat gat gca gac gaa ttt ggc tac agc cgc taa ggaggggatc        2935
Arg Ala Asp Asp Ala Asp Glu Phe Gly Tyr Ser Arg                           
    875                 880                 885                           

gggtttggcc cccagccccc gtcacgccag tccctcttcc tctgccggga gggtgttttc     2995

aactccaaac cccagagagg ggttgtacat tgggtccagc tttgcttcag tgtgtggaaa     3055

tgtctcgtgg ggtggcatcg gggctgcggg gtggggaccc caaggctttc tggggcagac     3115

ccttgtcctc tgggatgatg ggcactgcta tccacagtct ctgccagttg gttttatttg     3175

gaggtttgtg ggctttttta aaaaaaaaaa agtcctcaaa tcaggaagaa acatcaaaga     3235

ctatgtccta gtggagggag taatcctaac acccaggctg gccgccagct ggcacctgcc     3295

tctatcccag actgccctcg tcccagctct ctgtccaact gttgattatg tgatttttct     3355

gatacgtcca ttctcaaatg ccagtgtgtt cacatcttcg ctctggccag cccattctgt     3415

atttaaagct ttttgaggcc caataaaata gtacgtgctg ctgcagccct tattgatcaa     3475

aaaaa                                                                 3480


<210>  38
<211>  885
<212>  PRT
<213>  homo sapiens

<400>  38

Met Val Leu Ser Gly Cys Ala Ile Ile Val Arg Gly Gln Pro Arg Gly 
1               5                   10                  15      


Gly Pro Pro Pro Glu Arg Gln Ile Asn Leu Ser Asn Ile Arg Ala Gly 
            20                  25                  30          


Asn Leu Ala Arg Arg Ala Ala Ala Thr Gln Pro Asp Ala Lys Asp Thr 
        35                  40                  45              


Pro Asp Glu Pro Trp Ala Phe Pro Ala Arg Glu Phe Leu Arg Lys Lys 
    50                  55                  60                  


Leu Ile Gly Lys Glu Val Cys Phe Thr Ile Glu Asn Lys Thr Pro Gln 
65                  70                  75                  80  


Gly Arg Glu Tyr Gly Met Ile Tyr Leu Gly Lys Asp Thr Asn Gly Glu 
                85                  90                  95      


Asn Ile Ala Glu Ser Leu Val Ala Glu Gly Leu Ala Thr Arg Arg Glu 
            100                 105                 110         


Gly Met Arg Ala Asn Asn Pro Glu Gln Asn Arg Leu Ser Glu Cys Glu 
        115                 120                 125             


Glu Gln Ala Lys Ala Ala Lys Lys Gly Met Trp Ser Glu Gly Asn Gly 
    130                 135                 140                 


Ser His Thr Ile Arg Asp Leu Lys Tyr Thr Ile Glu Asn Pro Arg His 
145                 150                 155                 160 


Phe Val Asp Ser His His Gln Lys Pro Val Asn Ala Ile Ile Glu His 
                165                 170                 175     


Val Arg Asp Gly Ser Val Val Arg Ala Leu Leu Leu Pro Asp Tyr Tyr 
            180                 185                 190         


Leu Val Thr Val Met Leu Ser Gly Ile Lys Cys Pro Thr Phe Arg Arg 
        195                 200                 205             


Glu Ala Asp Gly Ser Glu Thr Pro Glu Pro Phe Ala Ala Glu Ala Lys 
    210                 215                 220                 


Phe Phe Thr Glu Ser Arg Leu Leu Gln Arg Asp Val Gln Ile Ile Leu 
225                 230                 235                 240 


Glu Ser Cys His Asn Gln Asn Ile Val Gly Thr Ile Leu His Pro Asn 
                245                 250                 255     


Gly Asn Ile Thr Glu Leu Leu Leu Lys Glu Gly Phe Ala Arg Cys Val 
            260                 265                 270         


Asp Trp Ser Ile Ala Val Tyr Thr Arg Gly Ala Glu Lys Leu Arg Ala 
        275                 280                 285             


Ala Glu Arg Phe Ala Lys Glu Arg Arg Leu Arg Ile Trp Arg Asp Tyr 
    290                 295                 300                 


Val Ala Pro Thr Ala Asn Leu Asp Gln Lys Asp Lys Gln Phe Val Ala 
305                 310                 315                 320 


Lys Val Met Gln Val Leu Asn Ala Asp Ala Ile Val Val Lys Leu Asn 
                325                 330                 335     


Ser Gly Asp Tyr Lys Thr Ile His Leu Ser Ser Ile Arg Pro Pro Arg 
            340                 345                 350         


Leu Glu Gly Glu Asn Thr Gln Asp Lys Asn Lys Lys Leu Arg Pro Leu 
        355                 360                 365             


Tyr Asp Ile Pro Tyr Met Phe Glu Ala Arg Glu Phe Leu Arg Lys Lys 
    370                 375                 380                 


Leu Ile Gly Lys Lys Val Asn Val Thr Val Asp Tyr Ile Arg Pro Ala 
385                 390                 395                 400 


Ser Pro Ala Thr Glu Thr Val Pro Ala Phe Ser Glu Arg Thr Cys Ala 
                405                 410                 415     


Thr Val Thr Ile Gly Gly Ile Asn Ile Ala Glu Ala Leu Val Ser Lys 
            420                 425                 430         


Gly Leu Ala Thr Val Ile Arg Tyr Arg Gln Asp Asp Asp Gln Arg Ser 
        435                 440                 445             


Ser His Tyr Asp Glu Leu Leu Ala Ala Glu Ala Arg Ala Ile Lys Asn 
    450                 455                 460                 


Gly Lys Gly Leu His Ser Lys Lys Glu Val Pro Ile His Arg Val Ala 
465                 470                 475                 480 


Asp Ile Ser Gly Asp Thr Gln Lys Ala Lys Gln Phe Leu Pro Phe Leu 
                485                 490                 495     


Gln Arg Ala Gly Arg Ser Glu Ala Val Val Glu Tyr Val Phe Ser Gly 
            500                 505                 510         


Ser Arg Leu Lys Leu Tyr Leu Pro Lys Glu Thr Cys Leu Ile Thr Phe 
        515                 520                 525             


Leu Leu Ala Gly Ile Glu Cys Pro Arg Gly Ala Arg Asn Leu Pro Gly 
    530                 535                 540                 


Leu Val Gln Glu Gly Glu Pro Phe Ser Glu Glu Ala Thr Leu Phe Thr 
545                 550                 555                 560 


Lys Glu Leu Val Leu Gln Arg Glu Val Glu Val Glu Val Glu Ser Met 
                565                 570                 575     


Asp Lys Ala Gly Asn Phe Ile Gly Trp Leu His Ile Asp Gly Ala Asn 
            580                 585                 590         


Leu Ser Val Leu Leu Val Glu His Ala Leu Ser Lys Val His Phe Thr 
        595                 600                 605             


Ala Glu Arg Ser Ser Tyr Tyr Lys Ser Leu Leu Ser Ala Glu Glu Ala 
    610                 615                 620                 


Ala Lys Gln Lys Lys Glu Lys Val Trp Ala His Tyr Glu Glu Gln Pro 
625                 630                 635                 640 


Val Glu Glu Val Met Pro Val Leu Glu Glu Lys Glu Arg Ser Ala Ser 
                645                 650                 655     


Tyr Lys Pro Val Phe Val Thr Glu Ile Thr Asp Asp Leu His Phe Tyr 
            660                 665                 670         


Val Gln Asp Val Glu Thr Gly Thr Gln Phe Gln Lys Leu Met Glu Asn 
        675                 680                 685             


Met Arg Asn Asp Ile Ala Ser His Pro Pro Val Glu Gly Ser Tyr Ala 
    690                 695                 700                 


Pro Arg Arg Gly Glu Phe Cys Ile Ala Lys Phe Val Asp Gly Glu Trp 
705                 710                 715                 720 


Tyr Arg Ala Arg Val Glu Lys Val Glu Ser Pro Ala Lys Ile His Val 
                725                 730                 735     


Phe Tyr Ile Asp Tyr Gly Asn Arg Glu Val Leu Pro Ser Thr Arg Leu 
            740                 745                 750         


Gly Thr Leu Ser Pro Ala Phe Ser Thr Arg Val Leu Pro Ala Gln Ala 
        755                 760                 765             


Thr Glu Tyr Ala Phe Ala Phe Ile Gln Val Pro Gln Asp Asp Asp Ala 
    770                 775                 780                 


Arg Thr Asp Ala Val Asp Ser Val Val Arg Asp Ile Gln Asn Thr Gln 
785                 790                 795                 800 


Cys Leu Leu Asn Val Glu His Leu Ser Ala Gly Cys Pro His Val Thr 
                805                 810                 815     


Leu Gln Phe Ala Asp Ser Lys Gly Asp Val Gly Leu Gly Leu Val Lys 
            820                 825                 830         


Glu Gly Leu Val Met Val Glu Val Arg Lys Glu Lys Gln Phe Gln Lys 
        835                 840                 845             


Val Ile Thr Glu Tyr Leu Asn Ala Gln Glu Ser Ala Lys Ser Ala Arg 
    850                 855                 860                 


Leu Asn Leu Trp Arg Tyr Gly Asp Phe Arg Ala Asp Asp Ala Asp Glu 
865                 870                 875                 880 


Phe Gly Tyr Ser Arg 
                885 


<210>  39
<211>  2331
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (49)..(1743)

<400>  39
cgcctccagc ctctcacact ctcctaagcc ctctcatctc ctggaacc atg gcc agc        57
                                                     Met Ala Ser          
                                                     1                    

aca tcc acc acc atc agg agc cac agc agc agc cgc cgg ggt ttc agt        105
Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg Gly Phe Ser           
    5                   10                  15                            

gcc aac tca gcc agg ctc cct ggg gtc agc cgc tct ggc ttc agc agc        153
Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly Phe Ser Ser           
20                  25                  30                  35            

atc tcc gtg tcc cgc tcc agg ggc agt ggt ggc ctg ggt ggc gca tgt        201
Ile Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly Gly Ala Cys           
                40                  45                  50                

gga gga gct ggc ttt ggc agc cgc agt ctg tat ggc ctg ggg ggc tcc        249
Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu Gly Gly Ser           
            55                  60                  65                    

aag agg atc tcc att gga ggg ggc agc tgt gcc atc agt ggc ggc tat        297
Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser Gly Gly Tyr           
        70                  75                  80                        

ggc agc aga gcc gga ggc agc tat ggc ttt ggt ggc gcc ggg agt gga        345
Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala Gly Ser Gly           
    85                  90                  95                            

ttt ggt ttc ggt ggt gga gcc ggc att ggc ttt ggt ctg ggt ggt gga        393
Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu Gly Gly Gly           
100                 105                 110                 115           

gcc ggc ctt gct ggt ggc ttt ggg ggc cct ggc ttc cct gtg tgc ccc        441
Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro Val Cys Pro           
                120                 125                 130               

cct gga ggc atc caa gag gtc act gtc aac cag agt ctc ctg act ccc        489
Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu Leu Thr Pro           
            135                 140                 145                   

ctc aac ctg caa att gac ccc gcc atc cag cgg gtg cgg gcc gag gag        537
Leu Asn Leu Gln Ile Asp Pro Ala Ile Gln Arg Val Arg Ala Glu Glu           
        150                 155                 160                       

cgt gag cag atc aag acc ctc aac aac aag ttt gcc tcc ttc atc gac        585
Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp           
    165                 170                 175                           

aag gtg cgg ttc cta gag cag cag aac aag gtt ctg gac acc aag tgg        633
Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp Thr Lys Trp           
180                 185                 190                 195           

acc ctg ctg cag gag cag ggc acc aag act gtg agg cag aac ctg gag        681
Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln Asn Leu Glu           
                200                 205                 210               

ccg ttg ttc gag cag tac atc aac aac ctc agg agg cag ctg gac aac        729
Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln Leu Asp Asn           
            215                 220                 225                   

atc gtg ggg gaa cgg ggt cgt ctg gac tcg gag ctg aga aac atg cag        777
Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg Asn Met Gln           
        230                 235                 240                       

gac ctg gtg gag gac ctc aag aac aaa tat gag gat gaa atc aac aag        825
Asp Leu Val Glu Asp Leu Lys Asn Lys Tyr Glu Asp Glu Ile Asn Lys           
    245                 250                 255                           

cgc aca gca gca gag aat gaa ttt gtg act ctg aag aag gat gtg gat        873
Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys Asp Val Asp           
260                 265                 270                 275           

gct gcc tac atg aac aag gtt gaa ctg caa gcc aag gca gac act ctt        921
Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala Asp Thr Leu           
                280                 285                 290               

aca gat gag atc aac ttc ctg aga gcc ttg tat gat gca gag ctg tcc        969
Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala Glu Leu Ser           
            295                 300                 305                   

cag atg cag acc cac atc tca gac aca tcc gtg gtg cta tcc atg gac       1017
Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu Ser Met Asp           
        310                 315                 320                       

aac aac cgc aac ctg gac ctg gac agc atc atc gct gag gtc aag gcc       1065
Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu Val Lys Ala           
    325                 330                 335                           

caa tat gag gag att gct cag agg agc agg gct gag gct gag tcc tgg       1113
Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala Glu Ser Trp           
340                 345                 350                 355           

tac cag aca aag tac gag gag ctg cag atc aca gca ggc aga cat ggg       1161
Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Ile Thr Ala Gly Arg His Gly           
                360                 365                 370               

gac gac ctg cgc aac acc aag cag gag att gct gag atc aac cgc atg       1209
Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile Asn Arg Met           
            375                 380                 385                   

atc cag agg ctg aga tct gag atc gac cac gtc aag aag cag tgt gcc       1257
Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys Gln Cys Ala           
        390                 395                 400                       

aac cta cag gcc gcc att gct gat gct gag cag cgt ggg gag atg gcc       1305
Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly Glu Met Ala           
    405                 410                 415                           

ctc aag gat gct aag aac aag ctg gaa ggg ctg gag gat gcc ctg cag       1353
Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp Ala Leu Gln           
420                 425                 430                 435           

aag gcc aag cag gac ctg gcc cgg ctg ctg aag gag tac cag gag ctg       1401
Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr Gln Glu Leu           
                440                 445                 450               

atg aac gtc aag ctg gcc ctg gat gtg gag atc gcc acc tac cgc aag       1449
Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr Tyr Arg Lys           
            455                 460                 465                   

ctg ctg gag ggc gag gag tgc agg ctg aat ggc gaa ggc gtt gga caa       1497
Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly Val Gly Gln           
        470                 475                 480                       

gtc aac atc tct gta gtg cag tcc acc gtc tcc agt ggc tat ggc ggt       1545
Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly Tyr Gly Gly           
    485                 490                 495                           

gcc agc ggt gtc ggc agt ggc tta ggc ctg ggt gga gga agc agc tac       1593
Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly Ser Ser Tyr           
500                 505                 510                 515           

tcc tat ggc agt ggt ctt ggc gtt gga ggc ggc ttt agt tcc agc agc       1641
Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser Ser Ser Ser           
                520                 525                 530               

ggc aga gcc act ggg ggt ggc ctc agc tct gtt gga ggc ggc agt tcc       1689
Gly Arg Ala Thr Gly Gly Gly Leu Ser Ser Val Gly Gly Gly Ser Ser           
            535                 540                 545                   

acc atc aag tac acc acc acc tcc tcc tcc agc agg aag agc tac aag       1737
Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys Ser Tyr Lys           
        550                 555                 560                       

cac tga agtgctgccg ccagctctca gtcccacagc tctcaggccc ctctctggca        1793
His                                                                       
                                                                          

gcagagccct ctcctcaggt tgcttgtcct cccctggcct ccagtctccc ctgccctccc     1853

gggtagagct gggatgccct cacttttctt ctcatcaata cctgttccac tgagctcctg     1913

ttgcttacca tcaagtcaac agttatcagc actcagacat gcgaatgtcc tttttagttc     1973

ccgtattatt acaggtatct gagtctgcca taattctgag aagaaaatga cctatatccc     2033

cataagaact gaaactcagt ctaggtccag ctgcagatga ggagtcctct ctttaattgc     2093

taaccatcct gcccattata gctacactca ggagttctca tctgacaagt cagttgtcct     2153

gatcttctct tgcagtgtcc ctgaatggca agtgatgtac cttctgatgc agtctgcatt     2213

cctgcactgc tttctctgct ctctttgcct tcttttgttc tgttgaataa agcatattga     2273

gaatgtgaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa       2331


<210>  40
<211>  564
<212>  PRT
<213>  homo sapiens

<400>  40

Met Ala Ser Thr Ser Thr Thr Ile Arg Ser His Ser Ser Ser Arg Arg 
1               5                   10                  15      


Gly Phe Ser Ala Asn Ser Ala Arg Leu Pro Gly Val Ser Arg Ser Gly 
            20                  25                  30          


Phe Ser Ser Ile Ser Val Ser Arg Ser Arg Gly Ser Gly Gly Leu Gly 
        35                  40                  45              


Gly Ala Cys Gly Gly Ala Gly Phe Gly Ser Arg Ser Leu Tyr Gly Leu 
    50                  55                  60                  


Gly Gly Ser Lys Arg Ile Ser Ile Gly Gly Gly Ser Cys Ala Ile Ser 
65                  70                  75                  80  


Gly Gly Tyr Gly Ser Arg Ala Gly Gly Ser Tyr Gly Phe Gly Gly Ala 
                85                  90                  95      


Gly Ser Gly Phe Gly Phe Gly Gly Gly Ala Gly Ile Gly Phe Gly Leu 
            100                 105                 110         


Gly Gly Gly Ala Gly Leu Ala Gly Gly Phe Gly Gly Pro Gly Phe Pro 
        115                 120                 125             


Val Cys Pro Pro Gly Gly Ile Gln Glu Val Thr Val Asn Gln Ser Leu 
    130                 135                 140                 


Leu Thr Pro Leu Asn Leu Gln Ile Asp Pro Ala Ile Gln Arg Val Arg 
145                 150                 155                 160 


Ala Glu Glu Arg Glu Gln Ile Lys Thr Leu Asn Asn Lys Phe Ala Ser 
                165                 170                 175     


Phe Ile Asp Lys Val Arg Phe Leu Glu Gln Gln Asn Lys Val Leu Asp 
            180                 185                 190         


Thr Lys Trp Thr Leu Leu Gln Glu Gln Gly Thr Lys Thr Val Arg Gln 
        195                 200                 205             


Asn Leu Glu Pro Leu Phe Glu Gln Tyr Ile Asn Asn Leu Arg Arg Gln 
    210                 215                 220                 


Leu Asp Asn Ile Val Gly Glu Arg Gly Arg Leu Asp Ser Glu Leu Arg 
225                 230                 235                 240 


Asn Met Gln Asp Leu Val Glu Asp Leu Lys Asn Lys Tyr Glu Asp Glu 
                245                 250                 255     


Ile Asn Lys Arg Thr Ala Ala Glu Asn Glu Phe Val Thr Leu Lys Lys 
            260                 265                 270         


Asp Val Asp Ala Ala Tyr Met Asn Lys Val Glu Leu Gln Ala Lys Ala 
        275                 280                 285             


Asp Thr Leu Thr Asp Glu Ile Asn Phe Leu Arg Ala Leu Tyr Asp Ala 
    290                 295                 300                 


Glu Leu Ser Gln Met Gln Thr His Ile Ser Asp Thr Ser Val Val Leu 
305                 310                 315                 320 


Ser Met Asp Asn Asn Arg Asn Leu Asp Leu Asp Ser Ile Ile Ala Glu 
                325                 330                 335     


Val Lys Ala Gln Tyr Glu Glu Ile Ala Gln Arg Ser Arg Ala Glu Ala 
            340                 345                 350         


Glu Ser Trp Tyr Gln Thr Lys Tyr Glu Glu Leu Gln Ile Thr Ala Gly 
        355                 360                 365             


Arg His Gly Asp Asp Leu Arg Asn Thr Lys Gln Glu Ile Ala Glu Ile 
    370                 375                 380                 


Asn Arg Met Ile Gln Arg Leu Arg Ser Glu Ile Asp His Val Lys Lys 
385                 390                 395                 400 


Gln Cys Ala Asn Leu Gln Ala Ala Ile Ala Asp Ala Glu Gln Arg Gly 
                405                 410                 415     


Glu Met Ala Leu Lys Asp Ala Lys Asn Lys Leu Glu Gly Leu Glu Asp 
            420                 425                 430         


Ala Leu Gln Lys Ala Lys Gln Asp Leu Ala Arg Leu Leu Lys Glu Tyr 
        435                 440                 445             


Gln Glu Leu Met Asn Val Lys Leu Ala Leu Asp Val Glu Ile Ala Thr 
    450                 455                 460                 


Tyr Arg Lys Leu Leu Glu Gly Glu Glu Cys Arg Leu Asn Gly Glu Gly 
465                 470                 475                 480 


Val Gly Gln Val Asn Ile Ser Val Val Gln Ser Thr Val Ser Ser Gly 
                485                 490                 495     


Tyr Gly Gly Ala Ser Gly Val Gly Ser Gly Leu Gly Leu Gly Gly Gly 
            500                 505                 510         


Ser Ser Tyr Ser Tyr Gly Ser Gly Leu Gly Val Gly Gly Gly Phe Ser 
        515                 520                 525             


Ser Ser Ser Gly Arg Ala Thr Gly Gly Gly Leu Ser Ser Val Gly Gly 
    530                 535                 540                 


Gly Ser Ser Thr Ile Lys Tyr Thr Thr Thr Ser Ser Ser Ser Arg Lys 
545                 550                 555                 560 


Ser Tyr Lys His 
                


<210>  41
<211>  818
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (247)..(564)

<400>  41
caaagggcgg cgcagcggct gccgagctcg gccctggagg cggcgagaac atggtgcgca       60

ggttcttggt gaccctccgg attcggcgcg cgtgcggccc gccgcgagtg agggttttcg      120

tggttcacat ctcgtggttc acgggggagt gggcagcgcc aggggcgccc gccgctgtgg      180

ccctcgtgct gatgctactg aggagccagc gtctagggca gcagccgctt cctagaagac      240

caggtc atg atg atg ggc agc gcc cga gtg gcg gag ctg ctg ctg ctc         288
       Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu            
       1               5                   10                             

cac ggc gcg gag ccc aac tgc gcc gac ccc gcc act ctc acc cga ccc        336
His Gly Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro           
15                  20                  25                  30            

gtg cac gac gct gcc cgg gag ggc ttc ctg gac acg ctg gtg gtg ctg        384
Val His Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu           
                35                  40                  45                

cac cgg gcc ggg gcg cgg ctg gac gtg cgc gat gcc tgg ggc cgt ctg        432
His Arg Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu           
            50                  55                  60                    

ccc gtg gac ctg gct gag gag ctg ggc cat cgc gat gtc gca cgg tac        480
Pro Val Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr           
        65                  70                  75                        

ctg cgc gcg gct gcg ggg ggc acc aga ggc agt aac cat gcc cgc ata        528
Leu Arg Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile           
    80                  85                  90                            

gat gcc gcg gaa ggt ccc tca gac atc ccc gat tga aagaaccaga             574
Asp Ala Ala Glu Gly Pro Ser Asp Ile Pro Asp                               
95                  100                 105                               

gaggctctga gaaacctccg gaaacttaga tcatcagtca ccgaaggtcc tacagggcca      634

caactgcccc cgccacaacc caccccgctt tcgtagtttt catttagaaa atagagcttt      694

taaaaatgtc ctgcctttta acgtagatat atgccttccc ccactaccgt aaatgtccat      754

ttatatcatt ttttatatat tcttataaaa atgtaaaaaa gaaaaaaaaa aaaaaaaaaa      814

aaaa                                                                   818


<210>  42
<211>  105
<212>  PRT
<213>  homo sapiens

<400>  42

Met Met Met Gly Ser Ala Arg Val Ala Glu Leu Leu Leu Leu His Gly 
1               5                   10                  15      


Ala Glu Pro Asn Cys Ala Asp Pro Ala Thr Leu Thr Arg Pro Val His 
            20                  25                  30          


Asp Ala Ala Arg Glu Gly Phe Leu Asp Thr Leu Val Val Leu His Arg 
        35                  40                  45              


Ala Gly Ala Arg Leu Asp Val Arg Asp Ala Trp Gly Arg Leu Pro Val 
    50                  55                  60                  


Asp Leu Ala Glu Glu Leu Gly His Arg Asp Val Ala Arg Tyr Leu Arg 
65                  70                  75                  80  


Ala Ala Ala Gly Gly Thr Arg Gly Ser Asn His Ala Arg Ile Asp Ala 
                85                  90                  95      


Ala Glu Gly Pro Ser Asp Ile Pro Asp 
            100                 105 


<210>  43
<211>  1154
<212>  DNA
<213>  homo sapiens


<220>
<221>  CDS
<222>  (38)..(559)

<400>  43
cgctcaggga aggcgggtgc gcgcctgcgg ggcggag atg ggc agg ggg cgg tgc        55
                                         Met Gly Arg Gly Arg Cys          
                                         1               5                

gtg ggt ccc agt ctg cag tta agg ggg cag gag tgg cgc tgc tca cct        103
Val Gly Pro Ser Leu Gln Leu Arg Gly Gln Glu Trp Arg Cys Ser Pro           
            10                  15                  20                    

ctg gtg cca aag ggc ggc gca gcg gct gcc gag ctc ggc cct gga ggc        151
Leu Val Pro Lys Gly Gly Ala Ala Ala Ala Glu Leu Gly Pro Gly Gly           
        25                  30                  35                        

ggc gag aac atg gtg cgc agg ttc ttg gtg acc ctc cgg att cgg cgc        199
Gly Glu Asn Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg           
    40                  45                  50                            

gcg tgc ggc ccg ccg cga gtg agg gtt ttc gtg gtt cac atc ccg cgg        247
Ala Cys Gly Pro Pro Arg Val Arg Val Phe Val Val His Ile Pro Arg           
55                  60                  65                  70            

ctc acg ggg gag tgg gca gcg cca ggg gcg ccc gcc gct gtg gcc ctc        295
Leu Thr Gly Glu Trp Ala Ala Pro Gly Ala Pro Ala Ala Val Ala Leu           
                75                  80                  85                

gtg ctg atg cta ctg agg agc cag cgt cta ggg cag cag ccg ctt cct        343
Val Leu Met Leu Leu Arg Ser Gln Arg Leu Gly Gln Gln Pro Leu Pro           
            90                  95                  100                   

aga aga cca ggt cat gat gat ggg cag cgc ccg agt ggc gga gct gct        391
Arg Arg Pro Gly His Asp Asp Gly Gln Arg Pro Ser Gly Gly Ala Ala           
        105                 110                 115                       

gct gct cca cgg cgc gga gcc caa ctg cgc cga ccc cgc cac tct cac        439
Ala Ala Pro Arg Arg Gly Ala Gln Leu Arg Arg Pro Arg His Ser His           
    120                 125                 130                           

ccg acc cgt gca cga cgc tgc ccg gga ggg ctt cct gga cac gct ggt        487
Pro Thr Arg Ala Arg Arg Cys Pro Gly Gly Leu Pro Gly His Ala Gly           
135                 140                 145                 150           

ggt gct gca ccg ggc cgg ggc gcg gct gga cgt gcg cga tgc ctg ggg        535
Gly Ala Ala Pro Gly Arg Gly Ala Ala Gly Arg Ala Arg Cys Leu Gly           
                155                 160                 165               

ccg tct gcc cgt gga cct ggc tga ggagctgggc catcgcgatg tcgcacggta       589
Pro Ser Ala Arg Gly Pro Gly                                               
            170                                                           

cctgcgcgcg gctgcggggg gcaccagagg cagtaaccat gcccgcatag atgccgcgga      649

aggtccctca gacatccccg attgaaagaa ccagagaggc tctgagaaac ctcgggaaac      709

ttagatcatc agtcaccgaa ggtcctacag ggccacaact gcccccgcca caacccaccc      769

cgctttcgta gttttcattt agaaaataga gcttttaaaa atgtcctgcc ttttaacgta      829

gatatatgcc ttcccccact accgtaaatg tccatttata tcatttttta tatattctta      889

taaaaatgta aaaaagaaaa acaccgcttc tgccttttca ctgtgttgga gttttctgga      949

gtgagcactc acgccctaag cgcacattca tgtgggcatt tcttgcgagc ctcgcagcct     1009

ccggaagctg tcgacttcat gacaagcatt ttgtgaacta gggaagctca ggggggttac     1069

tggcttctct tgagtcacac tgctagcaaa tggcagaacc aaagctcaaa taaaaataaa     1129

ataattttca ttcattcact caaaa                                           1154


<210>  44
<211>  173
<212>  PRT
<213>  homo sapiens

<400>  44

Met Gly Arg Gly Arg Cys Val Gly Pro Ser Leu Gln Leu Arg Gly Gln 
1               5                   10                  15      


Glu Trp Arg Cys Ser Pro Leu Val Pro Lys Gly Gly Ala Ala Ala Ala 
            20                  25                  30          


Glu Leu Gly Pro Gly Gly Gly Glu Asn Met Val Arg Arg Phe Leu Val 
        35                  40                  45              


Thr Leu Arg Ile Arg Arg Ala Cys Gly Pro Pro Arg Val Arg Val Phe 
    50                  55                  60                  


Val Val His Ile Pro Arg Leu Thr Gly Glu Trp Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Pro Ala Ala Val Ala Leu Val Leu Met Leu Leu Arg Ser Gln Arg Leu 
                85                  90                  95      


Gly Gln Gln Pro Leu Pro Arg Arg Pro Gly His Asp Asp Gly Gln Arg 
            100                 105                 110         


Pro Ser Gly Gly Ala Ala Ala Ala Pro Arg Arg Gly Ala Gln Leu Arg 
        115                 120                 125             


Arg Pro Arg His Ser His Pro Thr Arg Ala Arg Arg Cys Pro Gly Gly 
    130                 135                 140                 


Leu Pro Gly His Ala Gly Gly Ala Ala Pro Gly Arg Gly Ala Ala Gly 
145                 150                 155                 160 


Arg Ala Arg Cys Leu Gly Pro Ser Ala Arg Gly Pro Gly 
                165                 170             


<210>  45
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic IL8 forward primer

<400>  45
agatattgca cgggagaata tacaaa                                            26


<210>  46
<211>  27
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic IL8 reverse primer

<400>  46
tcaattcctg aaattaaagt tcggata                                           27


<210>  47
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PTGS2 forward primer

<400>  47
tctgcagagt tggaagcact cta                                               23


<210>  48
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PTGS2 reverse primer

<400>  48
gccgaggctt ttctaccaga a                                                 21


<210>  49
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic ILR8RB forward primer

<400>  49
catggcttga tcagcaagga                                                   20


<210>  50
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic ILR8RB reverse primer

<400>  50
tggaagtgtg ccctgaagaa g                                                 21


<210>  51
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic LCN2 forward primer

<400>  51
caaggagctg acttcggaac taa                                               23


<210>  52
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic LCN2 reverse primer

<400>  52
agggaagacg atgtggtttt ca                                                22


<210>  53
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic SAA1 forward primer

<400>  53
gggacatgtg gagagcctac tc                                                22


<210>  54
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic SAA1 reverse primer

<400>  54
catcatagtt cccccgagca t                                                 21


<210>  55
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CSF1 (MCSF1) forward primer

<400>  55
aagcagcacc agcaagtgaa g                                                 21


<210>  56
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CSF1 (MCSF1) reverse primer

<400>  56
tcatggcctg tgtcagtcaa a                                                 21


<210>  57
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic MGSA forward primer

<400>  57
acatgccagc cactgtgata ga                                                22


<210>  58
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic MGSA reverse primer

<400>  58
ccctgccttc acaatgatct c                                                 21


<210>  59
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CXCL3 forward primer

<400>  59
ggaattcacc tcaagaacat cca                                               23


<210>  60
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CXCL3 reverse primer

<400>  60
agtgtggcta tgacttcggt ttg                                               23


<210>  61
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic SPP1 (OPN) forward primer

<400>  61
cagccacaag cagtccagat ta                                                22


<210>  62
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic SPP1 (OPN) reverse primer

<400>  62
cctgactatc aatcacatcg gaat                                              24


<210>  63
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CCND1 forward primer

<400>  63
ccaggtgctc cacatgacag t                                                 21


<210>  64
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CCND1 reverse primer

<400>  64
aaacaaccaa caacaaggag aatg                                              24


<210>  65
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic c-Myc forward primer

<400>  65
cgtctccaca catcagcaca a                                                 21


<210>  66
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic c-Myc reverse primer

<400>  66
tcttggcagc aggatagtcc tt                                                22


<210>  67
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic HUMCDK1 forward primer

<400>  67
gcagaccagc atgacagatt tc                                                22


<210>  68
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic HUMCDK1 reverse primer

<400>  68
gcggattagg gcttcctctt                                                   20


<210>  69
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CDKN2A (p16) forward primer

<400>  69
ggcaccagag gcagtaacca t                                                 21


<210>  70
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CDKN2A (p16) reverse primer

<400>  70
agcctctctg gttctttcaa tcg                                               23


<210>  71
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CDKN2A (p14ARF) forward primer

<400>  71
tggttcacat cccgcggct                                                    19


<210>  72
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CDKN2A (p14ARF) reverse primer

<400>  72
tggctcctca gtagcatcag                                                   20


<210>  73
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PPARA forward primer

<400>  73
tgaagttcaa tgcactggaa ctg                                               23


<210>  74
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PPARA reverse primer

<400>  74
caggacgatc tccacagcaa                                                   20


<210>  75
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PPARG forward primer

<400>  75
tggagtccac gagatcattt aca                                               23


<210>  76
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PPARG reverse primer

<400>  76
agccttggcc ctcggatat                                                    19


<210>  77
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PPARD forward primer

<400>  77
cactgagttc gccaagagca t                                                 21


<210>  78
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PPARD reverse primer

<400>  78
cacgccatac ttgagaaggg taa                                               23


<210>  79
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CD44 forward primer

<400>  79
gctagtgatc aacagtggca atg                                               23


<210>  80
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CD44 reverse primer

<400>  80
gctggcctct ccgttgag                                                     18


<210>  81
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PTGS1 forward primer

<400>  81
tgttcggtgt ccagttccaa ta                                                22


<210>  82
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic PTGS1 reverse primer

<400>  82
tgccagtggt agagatggtt ga                                                22


<210>  83
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic HMGA1 forward primer

<400>  83
acaactccag gaaggaaacc aa                                                22


<210>  84
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic HMGA1 reverse primer

<400>  84
cgaggactcc tgcgagatg                                                    19


<210>  85
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CKSAS2 forward primer

<400>  85
tgaagaggag tggaggagac ttg                                               23


<210>  86
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic CKSHS2 reverse primer

<400>  86
gaatatgtgg ttctggctca tgaa                                              24


<210>  87
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic p100 coactivator forward primer

<400>  87
gagaaggagc gatctgctag ct                                                22


<210>  88
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic p100 coactivator reverse primer

<400>  88
cacgtagaag tgcaggtcat cag                                               23


