                         SEQUENCE LISTING

<110>  YEDA RESEARCH AND DEVELOPMENT CO. LTD.
       EISENBACH-SCHWARTZ, Michal
       ROLLS, Asya
       SCHECTER, Ravid
       LONDON, Anat
       ZIV, Yaniv
 
<120>  MODULATION OF TOLL-LIKE RECEPTORS FOR CONTROLLING NEUROGENESIS 
       AND NEURO/GLIAL TUMORS

<130>  EIS-SCHWARTZ43A PCT

<150>  US 60/951,184
<151>  2007-07-20

<160>  26    

<170>  PatentIn version 3.5

<210>  1
<211>  2582
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  1
gcagtgagga tgatgccagg atgatgtctg cctcgcgcct ggctgggact ctgatcccag       60

ccatggcctt cctctcctgc gtgagaccag aaagctggga gccctgcgtg gaggtggttc      120

ctaatattac ttatcaatgc atggagctga atttctacaa aatccccgac aacctcccct      180

tctcaaccaa gaacctggac ctgagcttta atcccctgag gcatttaggc agctatagct      240

tcttcagttt cccagaactg caggtgctgg atttatccag gtgtgaaatc cagacaattg      300

aagatggggc atatcagagc ctaagccacc tctctacctt aatattgaca ggaaacccca      360

tccagagttt agccctggga gccttttctg gactatcaag tttacagaag ctggtggctg      420

tggagacaaa tctagcatct ctagagaact tccccattgg acatctcaaa actttgaaag      480

aacttaatgt ggctcacaat cttatccaat ctttcaaatt acctgagtat ttttctaatc      540

tgaccaatct agagcacttg gacctttcca gcaacaagat tcaaagtatt tattgcacag      600

acttgcgggt tctacatcaa atgcccctac tcaatctctc tttagacctg tccctgaacc      660

ctatgaactt tatccaacca ggtgcattta aagaaattag gcttcataag ctgactttaa      720

gaaataattt tgatagttta aatgtaatga aaacttgtat tcaaggtctg gctggtttag      780

aagtccatcg tttggttctg ggagaattta gaaatgaagg aaacttggaa aagtttgaca      840

aatctgctct agagggcctg tgcaatttga ccattgaaga attccgatta gcatacttag      900

actactacct cgatgatatt attgacttat ttaattgttt gacaaatgtt tcttcatttt      960

ccctggtgag tgtgactatt gaaagggtaa aagacttttc ttataatttc ggatggcaac     1020

atttagaatt agttaactgt aaatttggac agtttcccac attgaaactc aaatctctca     1080

aaaggcttac tttcacttcc aacaaaggtg ggaatgcttt ttcagaagtt gatctaccaa     1140

gccttgagtt tctagatctc agtagaaatg gcttgagttt caaaggttgc tgttctcaaa     1200

gtgattttgg gacaaccagc ctaaagtatt tagatctgag cttcaatggt gttattacca     1260

tgagttcaaa cttcttgggc ttagaacaac tagaacatct ggatttccag cattccaatt     1320

tgaaacaaat gagtgagttt tcagtattcc tatcactcag aaacctcatt taccttgaca     1380

tttctcatac tcacaccaga gttgctttca atggcatctt caatggcttg tccagtctcg     1440

aagtcttgaa aatggctggc aattctttcc aggaaaactt ccttccagat atcttcacag     1500

agctgagaaa cttgaccttc ctggacctct ctcagtgtca actggagcag ttgtctccaa     1560

cagcatttaa ctcactctcc agtcttcagg tactaaatat gagccacaac aacttctttt     1620

cattggatac gtttccttat aagtgtctga actccctcca ggttcttgat tacagtctca     1680

atcacataat gacttccaaa aaacaggaac tacagcattt tccaagtagt ctagctttct     1740

taaatcttac tcagaatgac tttgcttgta cttgtgaaca ccagagtttc ctgcaatgga     1800

tcaaggacca gaggcagctc ttggtggaag ttgaacgaat ggaatgtgca acaccttcag     1860

ataagcaggg catgcctgtg ctgagtttga atatcacctg tcagatgaat aagaccatca     1920

ttggtgtgtc ggtcctcagt gtgcttgtag tatctgttgt agcagttctg gtctataagt     1980

tctattttca cctgatgctt cttgctggct gcataaagta tggtagaggt gaaaacatct     2040

atgatgcctt tgttatctac tcaagccagg atgaggactg ggtaaggaat gagctagtaa     2100

agaatttaga agaaggggtg cctccatttc agctctgcct tcactacaga gactttattc     2160

ccggtgtggc cattgctgcc aacatcatcc atgaaggttt ccataaaagc cgaaaggtga     2220

ttgttgtggt gtcccagcac ttcatccaga gccgctggtg tatctttgaa tatgagattg     2280

ctcagacctg gcagtttctg agcagtcgtg ctggtatcat cttcattgtc ctgcagaagg     2340

tggagaagac cctgctcagg cagcaggtgg agctgtaccg ccttctcagc aggaacactt     2400

acctggagtg ggaggacagt gtcctggggc ggcacatctt ctggagacga ctcagaaaag     2460

ccctgctgga tggtaaatca tggaatccag aaggaacagt gggtacagga tgcaattggc     2520

aggaagcaac atctatctga agaggaaaaa taaaaacctc ctgaggcatt tcttgcccag     2580

ct                                                                    2582


<210>  2
<211>  839
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  2

Met Met Ser Ala Ser Arg Leu Ala Gly Thr Leu Ile Pro Ala Met Ala 
1               5                   10                  15      


Phe Leu Ser Cys Val Arg Pro Glu Ser Trp Glu Pro Cys Val Glu Val 
            20                  25                  30          


Val Pro Asn Ile Thr Tyr Gln Cys Met Glu Leu Asn Phe Tyr Lys Ile 
        35                  40                  45              


Pro Asp Asn Leu Pro Phe Ser Thr Lys Asn Leu Asp Leu Ser Phe Asn 
    50                  55                  60                  


Pro Leu Arg His Leu Gly Ser Tyr Ser Phe Phe Ser Phe Pro Glu Leu 
65                  70                  75                  80  


Gln Val Leu Asp Leu Ser Arg Cys Glu Ile Gln Thr Ile Glu Asp Gly 
                85                  90                  95      


Ala Tyr Gln Ser Leu Ser His Leu Ser Thr Leu Ile Leu Thr Gly Asn 
            100                 105                 110         


Pro Ile Gln Ser Leu Ala Leu Gly Ala Phe Ser Gly Leu Ser Ser Leu 
        115                 120                 125             


Gln Lys Leu Val Ala Val Glu Thr Asn Leu Ala Ser Leu Glu Asn Phe 
    130                 135                 140                 


Pro Ile Gly His Leu Lys Thr Leu Lys Glu Leu Asn Val Ala His Asn 
145                 150                 155                 160 


Leu Ile Gln Ser Phe Lys Leu Pro Glu Tyr Phe Ser Asn Leu Thr Asn 
                165                 170                 175     


Leu Glu His Leu Asp Leu Ser Ser Asn Lys Ile Gln Ser Ile Tyr Cys 
            180                 185                 190         


Thr Asp Leu Arg Val Leu His Gln Met Pro Leu Leu Asn Leu Ser Leu 
        195                 200                 205             


Asp Leu Ser Leu Asn Pro Met Asn Phe Ile Gln Pro Gly Ala Phe Lys 
    210                 215                 220                 


Glu Ile Arg Leu His Lys Leu Thr Leu Arg Asn Asn Phe Asp Ser Leu 
225                 230                 235                 240 


Asn Val Met Lys Thr Cys Ile Gln Gly Leu Ala Gly Leu Glu Val His 
                245                 250                 255     


Arg Leu Val Leu Gly Glu Phe Arg Asn Glu Gly Asn Leu Glu Lys Phe 
            260                 265                 270         


Asp Lys Ser Ala Leu Glu Gly Leu Cys Asn Leu Thr Ile Glu Glu Phe 
        275                 280                 285             


Arg Leu Ala Tyr Leu Asp Tyr Tyr Leu Asp Asp Ile Ile Asp Leu Phe 
    290                 295                 300                 


Asn Cys Leu Thr Asn Val Ser Ser Phe Ser Leu Val Ser Val Thr Ile 
305                 310                 315                 320 


Glu Arg Val Lys Asp Phe Ser Tyr Asn Phe Gly Trp Gln His Leu Glu 
                325                 330                 335     


Leu Val Asn Cys Lys Phe Gly Gln Phe Pro Thr Leu Lys Leu Lys Ser 
            340                 345                 350         


Leu Lys Arg Leu Thr Phe Thr Ser Asn Lys Gly Gly Asn Ala Phe Ser 
        355                 360                 365             


Glu Val Asp Leu Pro Ser Leu Glu Phe Leu Asp Leu Ser Arg Asn Gly 
    370                 375                 380                 


Leu Ser Phe Lys Gly Cys Cys Ser Gln Ser Asp Phe Gly Thr Thr Ser 
385                 390                 395                 400 


Leu Lys Tyr Leu Asp Leu Ser Phe Asn Gly Val Ile Thr Met Ser Ser 
                405                 410                 415     


Asn Phe Leu Gly Leu Glu Gln Leu Glu His Leu Asp Phe Gln His Ser 
            420                 425                 430         


Asn Leu Lys Gln Met Ser Glu Phe Ser Val Phe Leu Ser Leu Arg Asn 
        435                 440                 445             


Leu Ile Tyr Leu Asp Ile Ser His Thr His Thr Arg Val Ala Phe Asn 
    450                 455                 460                 


Gly Ile Phe Asn Gly Leu Ser Ser Leu Glu Val Leu Lys Met Ala Gly 
465                 470                 475                 480 


Asn Ser Phe Gln Glu Asn Phe Leu Pro Asp Ile Phe Thr Glu Leu Arg 
                485                 490                 495     


Asn Leu Thr Phe Leu Asp Leu Ser Gln Cys Gln Leu Glu Gln Leu Ser 
            500                 505                 510         


Pro Thr Ala Phe Asn Ser Leu Ser Ser Leu Gln Val Leu Asn Met Ser 
        515                 520                 525             


His Asn Asn Phe Phe Ser Leu Asp Thr Phe Pro Tyr Lys Cys Leu Asn 
    530                 535                 540                 


Ser Leu Gln Val Leu Asp Tyr Ser Leu Asn His Ile Met Thr Ser Lys 
545                 550                 555                 560 


Lys Gln Glu Leu Gln His Phe Pro Ser Ser Leu Ala Phe Leu Asn Leu 
                565                 570                 575     


Thr Gln Asn Asp Phe Ala Cys Thr Cys Glu His Gln Ser Phe Leu Gln 
            580                 585                 590         


Trp Ile Lys Asp Gln Arg Gln Leu Leu Val Glu Val Glu Arg Met Glu 
        595                 600                 605             


Cys Ala Thr Pro Ser Asp Lys Gln Gly Met Pro Val Leu Ser Leu Asn 
    610                 615                 620                 


Ile Thr Cys Gln Met Asn Lys Thr Ile Ile Gly Val Ser Val Leu Ser 
625                 630                 635                 640 


Val Leu Val Val Ser Val Val Ala Val Leu Val Tyr Lys Phe Tyr Phe 
                645                 650                 655     


His Leu Met Leu Leu Ala Gly Cys Ile Lys Tyr Gly Arg Gly Glu Asn 
            660                 665                 670         


Ile Tyr Asp Ala Phe Val Ile Tyr Ser Ser Gln Asp Glu Asp Trp Val 
        675                 680                 685             


Arg Asn Glu Leu Val Lys Asn Leu Glu Glu Gly Val Pro Pro Phe Gln 
    690                 695                 700                 


Leu Cys Leu His Tyr Arg Asp Phe Ile Pro Gly Val Ala Ile Ala Ala 
705                 710                 715                 720 


Asn Ile Ile His Glu Gly Phe His Lys Ser Arg Lys Val Ile Val Val 
                725                 730                 735     


Val Ser Gln His Phe Ile Gln Ser Arg Trp Cys Ile Phe Glu Tyr Glu 
            740                 745                 750         


Ile Ala Gln Thr Trp Gln Phe Leu Ser Ser Arg Ala Gly Ile Ile Phe 
        755                 760                 765             


Ile Val Leu Gln Lys Val Glu Lys Thr Leu Leu Arg Gln Gln Val Glu 
    770                 775                 780                 


Leu Tyr Arg Leu Leu Ser Arg Asn Thr Tyr Leu Glu Trp Glu Asp Ser 
785                 790                 795                 800 


Val Leu Gly Arg His Ile Phe Trp Arg Arg Leu Arg Lys Ala Leu Leu 
                805                 810                 815     


Asp Gly Lys Ser Trp Asn Pro Glu Gly Thr Val Gly Thr Gly Cys Asn 
            820                 825                 830         


Trp Gln Glu Ala Thr Ser Ile 
        835                 


<210>  3
<211>  3417
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  3
cggaggcagc gagaaagcgc agccaggcgg ctgctcggcg ttctctcagg tgactgctcg       60

gagttctccc agtgtttggt gttgcaagca ggatccaaag gagacctata gtgactccca      120

ggagctctta gtgaccaagt gaaggtacct gtggggctca ttgtgcccat tgctctttca      180

ctgctttcaa ctggtagttg tgggttgaag cactggacaa tgccacatac tttgtggatg      240

gtgtgggtct tgggggtcat catcagcctc tccaaggaag aatcctccaa tcaggcttct      300

ctgtcttgtg accgcaatgg tatctgcaag ggcagctcag gatctttaaa ctccattccc      360

tcagggctca cagaagctgt aaaaagcctt gacctgtcca acaacaggat cacctacatt      420

agcaacagtg acctacagag gtgtgtgaac ctccaggctc tggtgctgac atccaatgga      480

attaacacaa tagaggaaga ttctttttct tccctgggca gtcttgaaca tttagactta      540

tcctataatt acttatctaa tttatcgtct tcctggttca agcccctttc ttctttaaca      600

ttcttaaact tactgggaaa tccttacaaa accctagggg aaacatctct tttttctcat      660

ctcacaaaat tgcaaatcct gagagtggga aatatggaca ccttcactaa gattcaaaga      720

aaagattttg ctggacttac cttccttgag gaacttgaga ttgatgcttc agatctacag      780

agctatgagc caaaaagttt gaagtcaatt cagaatgtaa gtcatctgat ccttcatatg      840

aagcagcata ttttactgct ggagattttt gtagatgtta caagttccgt ggaatgtttg      900

gaactgcgag atactgattt ggacactttc catttttcag aactatccac tggtgaaaca      960

aattcattga ttaaaaagtt tacatttaga aatgtgaaaa tcaccgatga aagtttgttt     1020

caggttatga aacttttgaa tcagatttct ggattgttag aattagagtt tgatgactgt     1080

acccttaatg gagttggtaa ttttagagca tctgataatg acagagttat agatccaggt     1140

aaagtggaaa cgttaacaat ccggaggctg catattccaa ggttttactt attttatgat     1200

ctgagcactt tatattcact tacagaaaga gttaaaagaa tcacagtaga aaacagtaaa     1260

gtttttctgg ttccttgttt actttcacaa catttaaaat cattagaata cttggatctc     1320

agtgaaaatt tgatggttga agaatacttg aaaaattcag cctgtgagga tgcctggccc     1380

tctctacaaa ctttaatttt aaggcaaaat catttggcat cattggaaaa aaccggagag     1440

actttgctca ctctgaaaaa cttgactaac attgatatca gtaagaatag ttttcattct     1500

atgcctgaaa cttgtcagtg gccagaaaag atgaaatatt tgaacttatc cagcacacga     1560

atacacagtg taacaggctg cattcccaag acactggaaa ttttagatgt tagcaacaac     1620

aatctcaatt tattttcttt gaatttgccg caactcaaag aactttatat ttccagaaat     1680

aagttgatga ctctaccaga tgcctccctc ttacccatgt tactagtatt gaaaatcagt     1740

aggaatgcaa taactacgtt ttctaaggag caacttgact catttcacac actgaagact     1800

ttggaagctg gtggcaataa cttcatttgc tcctgtgaat tcctctcctt cactcaggag     1860

cagcaagcac tggccaaagt cttgattgat tggccagcaa attacctgtg tgactctcca     1920

tcccatgtgc gtggccagca ggttcaggat gtccgcctct cggtgtcgga atgtcacagg     1980

acagcactgg tgtctggcat gtgctgtgct ctgttcctgc tgatcctgct cacgggggtc     2040

ctgtgccacc gtttccatgg cctgtggtat atgaaaatga tgtgggcctg gctccaggcc     2100

aaaaggaagc ccaggaaagc tcccagcagg aacatctgct atgatgcatt tgtttcttac     2160

agtgagcggg atgcctactg ggtggagaac cttatggtcc aggagctgga gaacttcaat     2220

ccccccttca agttgtgtct tcataagcgg gacttcattc ctggcaagtg gatcattgac     2280

aatatcattg actccattga aaagagccac aaaactgtct ttgtgctttc tgaaaacttt     2340

gtgaagagtg agtggtgcaa gtatgaactg gacttctccc atttccgtct ttttgatgag     2400

aacaatgatg ctgccattct cattcttctg gagcccattg agaaaaaagc cattccccag     2460

cgcttctgca agctgcggaa gataatgaac accaagacct acctggagtg gcccatggac     2520

gaggctcagc gggaaggatt ttgggtaaat ctgagagctg cgataaagtc ctaggttccc     2580

atatttaaga ccagtctttg tctagttggg atctttatgt cactagttat agttaagttc     2640

attcagacat aattatataa aaactacgtg gatgtaccgt catttgagga cttgcttact     2700

aaaactacaa aacttcaaat tttgtctggg gtgctgtttt ataaacatat gccagattta     2760

aaaattggtt tttggttttt cttttttcta tgagataacc atgatcataa gtctattact     2820

gatatctgaa tatagtccct tggtatccaa gggaattggt tgcaggatcc tcgtggatat     2880

caaaattcat agatgatcaa gtcccttata agagtggcat agtatttgca tataacctgt     2940

gtacattctc ctgtatactt taaatcatct ctagattact tatgataccc aatacaatgt     3000

aaatactatg taaatagttg tactgtcttt ttatttatat tattattgtt attttttatt     3060

ttcaaaattt ttaaaacata cttttgatcc acagttggtt gacttcatgg atgcagaacc     3120

catggatata gagggccaac tgtaatctgt agcaactggc ttagttcatt aggaaacagc     3180

acaaatgaac ttaagattct caatgactgt gtcattcttt cttcctgcta agagactcct     3240

ctgtggccac aaaaggcatt ctctgtccta cctagctgtc acttctctgt gcagctgatc     3300

tcaagagcaa caaggcaaag tatttggggc actccccaaa acttgttgct attcctagaa     3360

aaaagtgctg tgtatttcct attaaacttt acaggatgag aaaaaaaaaa aaaaaaa        3417


<210>  4
<211>  784
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  4

Met Pro His Thr Leu Trp Met Val Trp Val Leu Gly Val Ile Ile Ser 
1               5                   10                  15      


Leu Ser Lys Glu Glu Ser Ser Asn Gln Ala Ser Leu Ser Cys Asp Arg 
            20                  25                  30          


Asn Gly Ile Cys Lys Gly Ser Ser Gly Ser Leu Asn Ser Ile Pro Ser 
        35                  40                  45              


Gly Leu Thr Glu Ala Val Lys Ser Leu Asp Leu Ser Asn Asn Arg Ile 
    50                  55                  60                  


Thr Tyr Ile Ser Asn Ser Asp Leu Gln Arg Cys Val Asn Leu Gln Ala 
65                  70                  75                  80  


Leu Val Leu Thr Ser Asn Gly Ile Asn Thr Ile Glu Glu Asp Ser Phe 
                85                  90                  95      


Ser Ser Leu Gly Ser Leu Glu His Leu Asp Leu Ser Tyr Asn Tyr Leu 
            100                 105                 110         


Ser Asn Leu Ser Ser Ser Trp Phe Lys Pro Leu Ser Ser Leu Thr Phe 
        115                 120                 125             


Leu Asn Leu Leu Gly Asn Pro Tyr Lys Thr Leu Gly Glu Thr Ser Leu 
    130                 135                 140                 


Phe Ser His Leu Thr Lys Leu Gln Ile Leu Arg Val Gly Asn Met Asp 
145                 150                 155                 160 


Thr Phe Thr Lys Ile Gln Arg Lys Asp Phe Ala Gly Leu Thr Phe Leu 
                165                 170                 175     


Glu Glu Leu Glu Ile Asp Ala Ser Asp Leu Gln Ser Tyr Glu Pro Lys 
            180                 185                 190         


Ser Leu Lys Ser Ile Gln Asn Val Ser His Leu Ile Leu His Met Lys 
        195                 200                 205             


Gln His Ile Leu Leu Leu Glu Ile Phe Val Asp Val Thr Ser Ser Val 
    210                 215                 220                 


Glu Cys Leu Glu Leu Arg Asp Thr Asp Leu Asp Thr Phe His Phe Ser 
225                 230                 235                 240 


Glu Leu Ser Thr Gly Glu Thr Asn Ser Leu Ile Lys Lys Phe Thr Phe 
                245                 250                 255     


Arg Asn Val Lys Ile Thr Asp Glu Ser Leu Phe Gln Val Met Lys Leu 
            260                 265                 270         


Leu Asn Gln Ile Ser Gly Leu Leu Glu Leu Glu Phe Asp Asp Cys Thr 
        275                 280                 285             


Leu Asn Gly Val Gly Asn Phe Arg Ala Ser Asp Asn Asp Arg Val Ile 
    290                 295                 300                 


Asp Pro Gly Lys Val Glu Thr Leu Thr Ile Arg Arg Leu His Ile Pro 
305                 310                 315                 320 


Arg Phe Tyr Leu Phe Tyr Asp Leu Ser Thr Leu Tyr Ser Leu Thr Glu 
                325                 330                 335     


Arg Val Lys Arg Ile Thr Val Glu Asn Ser Lys Val Phe Leu Val Pro 
            340                 345                 350         


Cys Leu Leu Ser Gln His Leu Lys Ser Leu Glu Tyr Leu Asp Leu Ser 
        355                 360                 365             


Glu Asn Leu Met Val Glu Glu Tyr Leu Lys Asn Ser Ala Cys Glu Asp 
    370                 375                 380                 


Ala Trp Pro Ser Leu Gln Thr Leu Ile Leu Arg Gln Asn His Leu Ala 
385                 390                 395                 400 


Ser Leu Glu Lys Thr Gly Glu Thr Leu Leu Thr Leu Lys Asn Leu Thr 
                405                 410                 415     


Asn Ile Asp Ile Ser Lys Asn Ser Phe His Ser Met Pro Glu Thr Cys 
            420                 425                 430         


Gln Trp Pro Glu Lys Met Lys Tyr Leu Asn Leu Ser Ser Thr Arg Ile 
        435                 440                 445             


His Ser Val Thr Gly Cys Ile Pro Lys Thr Leu Glu Ile Leu Asp Val 
    450                 455                 460                 


Ser Asn Asn Asn Leu Asn Leu Phe Ser Leu Asn Leu Pro Gln Leu Lys 
465                 470                 475                 480 


Glu Leu Tyr Ile Ser Arg Asn Lys Leu Met Thr Leu Pro Asp Ala Ser 
                485                 490                 495     


Leu Leu Pro Met Leu Leu Val Leu Lys Ile Ser Arg Asn Ala Ile Thr 
            500                 505                 510         


Thr Phe Ser Lys Glu Gln Leu Asp Ser Phe His Thr Leu Lys Thr Leu 
        515                 520                 525             


Glu Ala Gly Gly Asn Asn Phe Ile Cys Ser Cys Glu Phe Leu Ser Phe 
    530                 535                 540                 


Thr Gln Glu Gln Gln Ala Leu Ala Lys Val Leu Ile Asp Trp Pro Ala 
545                 550                 555                 560 


Asn Tyr Leu Cys Asp Ser Pro Ser His Val Arg Gly Gln Gln Val Gln 
                565                 570                 575     


Asp Val Arg Leu Ser Val Ser Glu Cys His Arg Thr Ala Leu Val Ser 
            580                 585                 590         


Gly Met Cys Cys Ala Leu Phe Leu Leu Ile Leu Leu Thr Gly Val Leu 
        595                 600                 605             


Cys His Arg Phe His Gly Leu Trp Tyr Met Lys Met Met Trp Ala Trp 
    610                 615                 620                 


Leu Gln Ala Lys Arg Lys Pro Arg Lys Ala Pro Ser Arg Asn Ile Cys 
625                 630                 635                 640 


Tyr Asp Ala Phe Val Ser Tyr Ser Glu Arg Asp Ala Tyr Trp Val Glu 
                645                 650                 655     


Asn Leu Met Val Gln Glu Leu Glu Asn Phe Asn Pro Pro Phe Lys Leu 
            660                 665                 670         


Cys Leu His Lys Arg Asp Phe Ile Pro Gly Lys Trp Ile Ile Asp Asn 
        675                 680                 685             


Ile Ile Asp Ser Ile Glu Lys Ser His Lys Thr Val Phe Val Leu Ser 
    690                 695                 700                 


Glu Asn Phe Val Lys Ser Glu Trp Cys Lys Tyr Glu Leu Asp Phe Ser 
705                 710                 715                 720 


His Phe Arg Leu Phe Asp Glu Asn Asn Asp Ala Ala Ile Leu Ile Leu 
                725                 730                 735     


Leu Glu Pro Ile Glu Lys Lys Ala Ile Pro Gln Arg Phe Cys Lys Leu 
            740                 745                 750         


Arg Lys Ile Met Asn Thr Lys Thr Tyr Leu Glu Trp Pro Met Asp Glu 
        755                 760                 765             


Ala Gln Arg Glu Gly Phe Trp Val Asn Leu Arg Ala Ala Ile Lys Ser 
    770                 775                 780                 


<210>  5
<211>  2517
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  5
atgatgtctg cctcgcgcct ggctgggact ctgatcccag ccatggcctt cctctcctgc       60

gtgagaccag aaagctggga gccctgcgtg gaggtggttc ctaatattac ttatcaatgc      120

atggagctga atttctacaa aatccccgac aacctcccct tctcaaccaa gaacctggac      180

ctgagcttta atcccctgag gcatttaggc agctatagct tcttcagttt cccagaactg      240

caggtgctgg atttatccag gtgtgaaatc cagacaattg aagatggggc atatcagagc      300

ctaagccacc tctctacctt aatattgaca ggaaacccca tccagagttt agccctggga      360

gccttttctg gactatcaag tttacagaag ctggtggctg tggagacaaa tctagcatct      420

ctagagaact tccccattgg acatctcaaa actttgaaag aacttaatgt ggctcacaat      480

cttatccaat ctttcaaatt acctgagtat ttttctaatc tgaccaatct agagcacttg      540

gacctttcca gcaacaagat tcaaagtatt tattgcacag acttgcgggt tctacatcaa      600

atgcccctac tcaatctctc tttagacctg tccctgaacc ctatgaactt tatccaacca      660

ggtgcattta aagaaattag gcttcataag ctgactttaa gaaataattt tgatagttta      720

aatgtaatga aaacttgtat tcaaggtctg gctggtttag aagtccatcg tttggttctg      780

ggagaattta gaaatgaagg aaacttggaa aagtttgaca aatctgctct agagggcctg      840

tgcaatttga ccattgaaga attccgatta gcatacttag actactacct cgatgatatt      900

attgacttat ttaattgttt gacaaatgtt tcttcatttt ccctggtgag tgtgactatt      960

gaaagggtaa aagacttttc ttataatttc ggatggcaac atttagaatt agttaactgt     1020

aaatttggac agtttcccac attgaaactc aaatctctca aaaggcttac tttcacttcc     1080

aacaaaggtg ggaatgcttt ttcagaagtt gatctaccaa gccttgagtt tctagatctc     1140

agtagaaatg gcttgagttt caaaggttgc tgttctcaaa gtgattttgg gacaaccagc     1200

ctaaagtatt tagatctgag cttcaatggt gttattacca tgagttcaaa cttcttgggc     1260

ttagaacaac tagaacatct ggatttccag cattccaatt tgaaacaaat gagtgagttt     1320

tcagtattcc tatcactcag aaacctcatt taccttgaca tttctcatac tcacaccaga     1380

gttgctttca atggcatctt caatggcttg tccagtctcg aagtcttgaa aatggctggc     1440

aattctttcc aggaaaactt ccttccagat atcttcacag agctgagaaa cttgaccttc     1500

ctggacctct ctcagtgtca actggagcag ttgtctccaa cagcatttaa ctcactctcc     1560

agtcttcagg tactaaatat gagccacaac aacttctttt cattggatac gtttccttat     1620

aagtgtctga actccctcca ggttcttgat tacagtctca atcacataat gacttccaaa     1680

aaacaggaac tacagcattt tccaagtagt ctagctttct taaatcttac tcagaatgac     1740

tttgcttgta cttgtgaaca ccagagtttc ctgcaatgga tcaaggacca gaggcagctc     1800

ttggtggaag ttgaacgaat ggaatgtgca acaccttcag ataagcaggg catgcctgtg     1860

ctgagtttga atatcacctg tcagatgaat aagaccatca ttggtgtgtc ggtcctcagt     1920

gtgcttgtag tatctgttgt agcagttctg gtctataagt tctattttca cctgatgctt     1980

cttgctggct gcataaagta tggtagaggt gaaaacatct atgatgcctt tgttatctac     2040

tcaagccagg atgaggactg ggtaaggaat gagctagtaa agaatttaga agaaggggtg     2100

cctccatttc agctctgcct tcactacaga gactttattc ccggtgtggc cattgctgcc     2160

aacatcatcc atgaaggttt ccataaaagc cgaaaggtga ttgttgtggt gtcccagcac     2220

ttcatccaga gccgctggtg tatctttgaa tatgagattg ctcagacctg gcagtttctg     2280

agcagtcgtg ctggtatcat cttcattgtc ctgcagaagg tggagaagac cctgctcagg     2340

cagcaggtgg agctgtaccg ccttctcagc aggaacactt acctggagtg ggaggacagt     2400

gtcctggggc ggcacatctt ctggagacga ctcagaaaag ccctgctgga tggtaaatca     2460

tggaatccag aaggaacagt gggtacagga tgcaattggc aggaagcaac atctatc        2517


<210>  6
<211>  2352
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  6
atgccacata ctttgtggat ggtgtgggtc ttgggggtca tcatcagcct ctccaaggaa       60

gaatcctcca atcaggcttc tctgtcttgt gaccgcaatg gtatctgcaa gggcagctca      120

ggatctttaa actccattcc ctcagggctc acagaagctg taaaaagcct tgacctgtcc      180

aacaacagga tcacctacat tagcaacagt gacctacaga ggtgtgtgaa cctccaggct      240

ctggtgctga catccaatgg aattaacaca atagaggaag attctttttc ttccctgggc      300

agtcttgaac atttagactt atcctataat tacttatcta atttatcgtc ttcctggttc      360

aagccccttt cttctttaac attcttaaac ttactgggaa atccttacaa aaccctaggg      420

gaaacatctc ttttttctca tctcacaaaa ttgcaaatcc tgagagtggg aaatatggac      480

accttcacta agattcaaag aaaagatttt gctggactta ccttccttga ggaacttgag      540

attgatgctt cagatctaca gagctatgag ccaaaaagtt tgaagtcaat tcagaatgta      600

agtcatctga tccttcatat gaagcagcat attttactgc tggagatttt tgtagatgtt      660

acaagttccg tggaatgttt ggaactgcga gatactgatt tggacacttt ccatttttca      720

gaactatcca ctggtgaaac aaattcattg attaaaaagt ttacatttag aaatgtgaaa      780

atcaccgatg aaagtttgtt tcaggttatg aaacttttga atcagatttc tggattgtta      840

gaattagagt ttgatgactg tacccttaat ggagttggta attttagagc atctgataat      900

gacagagtta tagatccagg taaagtggaa acgttaacaa tccggaggct gcatattcca      960

aggttttact tattttatga tctgagcact ttatattcac ttacagaaag agttaaaaga     1020

atcacagtag aaaacagtaa agtttttctg gttccttgtt tactttcaca acatttaaaa     1080

tcattagaat acttggatct cagtgaaaat ttgatggttg aagaatactt gaaaaattca     1140

gcctgtgagg atgcctggcc ctctctacaa actttaattt taaggcaaaa tcatttggca     1200

tcattggaaa aaaccggaga gactttgctc actctgaaaa acttgactaa cattgatatc     1260

agtaagaata gttttcattc tatgcctgaa acttgtcagt ggccagaaaa gatgaaatat     1320

ttgaacttat ccagcacacg aatacacagt gtaacaggct gcattcccaa gacactggaa     1380

attttagatg ttagcaacaa caatctcaat ttattttctt tgaatttgcc gcaactcaaa     1440

gaactttata tttccagaaa taagttgatg actctaccag atgcctccct cttacccatg     1500

ttactagtat tgaaaatcag taggaatgca ataactacgt tttctaagga gcaacttgac     1560

tcatttcaca cactgaagac tttggaagct ggtggcaata acttcatttg ctcctgtgaa     1620

ttcctctcct tcactcagga gcagcaagca ctggccaaag tcttgattga ttggccagca     1680

aattacctgt gtgactctcc atcccatgtg cgtggccagc aggttcagga tgtccgcctc     1740

tcggtgtcgg aatgtcacag gacagcactg gtgtctggca tgtgctgtgc tctgttcctg     1800

ctgatcctgc tcacgggggt cctgtgccac cgtttccatg gcctgtggta tatgaaaatg     1860

atgtgggcct ggctccaggc caaaaggaag cccaggaaag ctcccagcag gaacatctgc     1920

tatgatgcat ttgtttctta cagtgagcgg gatgcctact gggtggagaa ccttatggtc     1980

caggagctgg agaacttcaa tccccccttc aagttgtgtc ttcataagcg ggacttcatt     2040

cctggcaagt ggatcattga caatatcatt gactccattg aaaagagcca caaaactgtc     2100

tttgtgcttt ctgaaaactt tgtgaagagt gagtggtgca agtatgaact ggacttctcc     2160

catttccgtc tttttgatga gaacaatgat gctgccattc tcattcttct ggagcccatt     2220

gagaaaaaag ccattcccca gcgcttctgc aagctgcgga agataatgaa caccaagacc     2280

tacctggagt ggcccatgga cgaggctcag cgggaaggat tttgggtaaa tctgagagct     2340

gcgataaagt cc                                                         2352


<210>  7
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  7
taaaacgcag ctcagtaaca gtccg                                             25


<210>  8
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  8
tggaatcctg tggcatccat gaaac                                             25


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  9
atgattctgc ctgggtgaag                                                   20


<210>  10
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  10
tctggatgaa gtggggagac                                                   20


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  11
ctcccacttc aggctctttg                                                   20


<210>  12
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  12
aggaactggg tggagaacct                                                   20


<210>  13
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  13
agctttgctg ggaactttca                                                   20


<210>  14
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  14
gaaagatcga gctgggtgag                                                   20


<210>  15
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  15
cagcaaagtc cctgatgaca                                                   20


<210>  16
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  16
agaggtggtg taagccatgc                                                   20


<210>  17
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  17
attctcatcg tggtggtggt                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  18
gctatggttc gcaactggat                                                   20


<210>  19
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  19
acacaatcgg ttgcaaaaca                                                   20


<210>  20
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  20
ggaaagtcag cttcgtcagg                                                   20


<210>  21
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  21
ccacaggctc acccatactt v                                                 21


<210>  22
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  22
caaggcatgt cctaggtggt                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  23
ggcacaactc ccttgtgatt                                                   20


<210>  24
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  24
catttgggtg ctgttgtttg                                                   20


<210>  25
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  25
gctttggcct ttcactcttg                                                   20


<210>  26
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
aactgcgctc tgtgccttat                                                   20


