                         SEQUENCE LISTING

<110>  Novavax, Inc.
 
<120>  Chimeric Varicella Zoster Virus  VLPs

<130>  NOVV-035/02WO

<150>  US 61/071,835
<151>  2008-05-20

<150>  US 60/970,592
<151>  2007-09-07

<150>  US 60/950,707
<151>  2007-07-19

<160>  13    

<170>  PatentIn version 3.5

<210>  1
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VZV gE with influenza indo IndoTM/CT

<400>  1

Met Gly Thr Val Asn Lys Pro Val Val Gly Val Leu Met Gly Phe Gly 
1               5                   10                  15      


Ile Ile Thr Gly Thr Leu Arg Ile Thr Asn Pro Val Arg Ala Ser Val 
            20                  25                  30          


Leu Arg Tyr Asp Asp Phe His Thr Asp Glu Asp Lys Leu Asp Thr Asn 
        35                  40                  45              


Ser Val Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp 
    50                  55                  60                  


Val Asn Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro 
65                  70                  75                  80  


Tyr Ile Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His 
                85                  90                  95      


Glu His His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu 
            100                 105                 110         


Arg Leu Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp 
        115                 120                 125             


Asp Thr Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His 
    130                 135                 140                 


Lys Ile Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly 
145                 150                 155                 160 


Asp Leu Asn Pro Lys Pro Gln Gly Gln Arg Leu Ile Glu Val Ser Val 
                165                 170                 175     


Glu Glu Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr 
            180                 185                 190         


Gly Val Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys 
        195                 200                 205             


Thr Gly Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr 
    210                 215                 220                 


Thr Cys Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr 
225                 230                 235                 240 


Lys Glu Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys 
                245                 250                 255     


Glu Ala Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp 
            260                 265                 270         


Glu Leu Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val 
        275                 280                 285             


Leu Arg Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg 
    290                 295                 300                 


Gly Ser Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys 
305                 310                 315                 320 


Gly Asp Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro 
                325                 330                 335     


Arg Gly Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser 
            340                 345                 350         


Val Gly Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His 
        355                 360                 365             


Glu Ala Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp 
    370                 375                 380                 


Pro Thr Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro 
385                 390                 395                 400 


Asn Ala Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr 
                405                 410                 415     


Ser Pro His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys 
            420                 425                 430         


Glu His Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met 
        435                 440                 445             


Glu Pro Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys 
    450                 455                 460                 


Phe Val Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val 
465                 470                 475                 480 


Tyr Phe Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr 
                485                 490                 495     


Val Asp His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr 
            500                 505                 510         


Ala Gly Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val 
        515                 520                 525             


Asn Pro Gly Thr Ser Pro Leu Leu Arg Gln Ile Leu Ser Ile Tyr Ser 
    530                 535                 540                 


Thr Val Ala Ser Ser Leu Ala Leu Ala Ile Met Met Ala Gly Leu Ser 
545                 550                 555                 560 


Leu Trp Met Cys Ser Asn Gly Ser Leu Gln Cys Arg Ile Cys Ile 
                565                 570                 575 


<210>  2
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  VZV gE with influenza indo IndoTM/CT

<400>  2
atgggcaccg tgaacaagcc cgtggtgggc gtgctgatgg gtttcggtat catcaccggc       60

accctgcgta tcaccaaccc cgtgcgtgct tccgtgctgc gttacgacga cttccacacc      120

gacgaggaca agctggacac caactccgtg tacgagccct actaccactc cgaccacgct      180

gagtcctctt gggtgaaccg tggcgagtcc tcccgtaagg cttacgacca caactccccc      240

tacatctggc cccgtaacga ctacgacggt ttcctcgaga acgctcacga gcaccacggt      300

gtctacaacc agggtcgtgg tatcgactcc ggcgagcgtc tgatgcagcc cacccagatg      360

tccgctcagg aagatctggg cgacgacacc ggtatccacg tgatccccac cctgaacggt      420

gacgaccgtc acaagatcgt gaacgtggac cagcgccagt acggtgacgt gttcaagggt      480

gacctgaacc ccaagcccca gggccagcgt ctgatcgagg tgtccgtgga ggaaaaccac      540

cccttcaccc tgcgtgctcc catccagcgt atctacggtg tccgttacac cgagacctgg      600

tccttcctcc cctccctgac ctgcaccggt gacgctgctc ccgctatcca gcacatctgc      660

ctgaagcaca ccacctgctt ccaggacgtg gtggtggacg tggactgcgc tgagaacacc      720

aaggaagatc agctggctga gatctcctac aggttccagg gcaagaagga agctgaccag      780

ccctggatcg tggtgaacac ctccaccctg ttcgacgagc tggaactgga cccccccgag      840

atcgagcccg gtgtcctgaa ggtgctgcgt accgagaagc agtacctggg cgtgtacatc      900

tggaacatgc gtggttccga cggcacctcc acctacgcta ccttcctcgt gacctggaag      960

ggtgacgaaa agacccgtaa ccccaccccc gctgtgaccc cccagccccg tggtgctgaa     1020

ttccacatgt ggaactacca ctctcacgtg ttctccgtgg gtgacacctt ctccctggct     1080

atgcacctgc agtacaagat ccacgaggct cccttcgacc tgctgctcga gtggctgtac     1140

gtgcccatcg accccacctg ccagcccatg cgcctgtact ccacctgcct gtaccacccc     1200

aacgctcccc agtgcctgtc ccacatgaac tccggttgca ccttcacctc cccccacctg     1260

gcccagcgtg tggcttccac cgtgtaccag aactgcgagc acgctgacaa ctacaccgct     1320

tactgcctgg gtatcagcca catggaacct tccttcggtc tgatcctgca cgacggtggc     1380

accaccctga agttcgtgga cacccccgag tccctgtccg gtctgtacgt gttcgtggtg     1440

tacttcaacg gtcacgtgga ggctgtcgct tacaccgtgg tgtccaccgt ggaccacttc     1500

gtgaacgcta tcgaggaacg tggtttcccc cccaccgctg gccagccccc tgctaccacc     1560

aagcccaagg aaatcacccc cgtcaacccc ggcacctccc ctctgctgcg tcagatcctg     1620

tccatctact ccaccgtggc ttcctccctg gctctggcta tcatgatggc tggtctgtcc     1680

ctgtggatgt gctccaacgg ttccctgcag tgccgtatct gcatctaa                  1728


<210>  3
<211>  310
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VZV gI with indo IndoTM/CT

<400>  3

Met Phe Leu Ile Gln Cys Leu Ile Ser Ala Val Ile Phe Tyr Ile Gln 
1               5                   10                  15      


Val Thr Asn Ala Leu Ile Phe Lys Gly Asp His Val Ser Leu Gln Val 
            20                  25                  30          


Asn Ser Ser Leu Thr Ser Ile Leu Ile Pro Met Gln Asn Asp Asn Tyr 
        35                  40                  45              


Thr Glu Ile Lys Gly Gln Leu Val Phe Ile Gly Glu Gln Leu Pro Thr 
    50                  55                  60                  


Gly Thr Asn Tyr Ser Gly Thr Leu Glu Leu Leu Tyr Ala Asp Thr Val 
65                  70                  75                  80  


Ala Phe Cys Phe Arg Ser Val Gln Val Ile Arg Tyr Asp Gly Cys Pro 
                85                  90                  95      


Arg Ile Arg Thr Ser Ala Phe Ile Ser Cys Arg Tyr Lys His Ser Trp 
            100                 105                 110         


His Tyr Gly Asn Ser Thr Asp Arg Ile Ser Thr Glu Pro Asp Ala Gly 
        115                 120                 125             


Val Met Leu Lys Ile Thr Lys Pro Gly Ile Asn Asp Ala Gly Val Tyr 
    130                 135                 140                 


Val Leu Leu Val Arg Leu Asp His Ser Arg Ser Thr Asp Gly Phe Ile 
145                 150                 155                 160 


Leu Gly Val Asn Val Tyr Thr Ala Gly Ser His His Asn Ile His Gly 
                165                 170                 175     


Val Ile Tyr Thr Ser Pro Ser Leu Gln Asn Gly Tyr Ser Thr Arg Ala 
            180                 185                 190         


Leu Phe Gln Gln Ala Arg Leu Cys Asp Leu Pro Ala Thr Pro Lys Gly 
        195                 200                 205             


Ser Gly Thr Ser Leu Phe Gln His Met Leu Asp Leu Arg Ala Gly Lys 
    210                 215                 220                 


Ser Leu Glu Asp Asn Pro Trp Leu His Glu Asp Val Val Thr Thr Glu 
225                 230                 235                 240 


Thr Lys Ser Val Val Lys Glu Gly Ile Glu Asn His Val Tyr Pro Thr 
                245                 250                 255     


Asp Met Ser Thr Leu Pro Glu Lys Ser Leu Asn Asp Pro Pro Glu Asn 
            260                 265                 270         


Gln Ile Leu Ser Ile Tyr Ser Thr Val Ala Ser Ser Leu Ala Leu Ala 
        275                 280                 285             


Ile Met Met Ala Gly Leu Ser Leu Trp Met Cys Ser Asn Gly Ser Leu 
    290                 295                 300                 


Gln Cys Arg Ile Cys Ile 
305                 310 


<210>  4
<211>  933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  gI_gE with indo IndoTM/CT

<400>  4
atgttcctca tccagtgcct gatctccgct gtgatcttct acatccaagt gaccaacgct       60

ctgatcttca agggtgacca cgtgtccctg caggtcaact cctccctgac ctccatcctg      120

atccccatgc agaacgacaa ctacaccgag atcaagggcc agctggtgtt catcggcgag      180

cagctgccca ccggcaccaa ctactccggc accctcgagc tgctgtacgc tgacaccgtc      240

gctttctgct tccgttccgt gcaggtgatc cgttacgacg gttgcccccg tatccgtacc      300

tccgctttca tctcctgccg ttacaagcac tcctggcact acggtaactc caccgaccgt      360

atctccaccg agcccgacgc tggtgtcatg ctgaagatca ccaagcccgg tatcaacgac      420

gctggcgtgt acgtgctgct ggtccgtctg gaccactccc gttccaccga cggtttcatc      480

ctgggtgtca acgtgtacac cgctggttcc caccacaaca tccacggtgt catctacacc      540

tccccctccc tgcagaacgg ttactccacc cgtgctctgt tccagcaggc tcgtctgtgc      600

gacctgcccg ctacccccaa gggttccggc acctccctct tccagcacat gctggacctg      660

cgtgctggca agtccctcga ggacaacccc tggctgcacg aggacgtggt gaccaccgag      720

accaagtccg tggtgaagga aggtatcgag aaccacgtgt accccaccga catgtccacc      780

ctgcccgaga agtccctgaa cgaccccccc gagaaccaga tcctgtccat ctactccacc      840

gtcgcttcct ccctggctct ggctatcatg atggctggcc tgtccctgtg gatgtgctcc      900

aacggttccc tgcagtgccg tatctgcatc taa                                   933


<210>  5
<211>  623
<212>  PRT
<213>  Varicella Zoster Virus

<400>  5

Met Gly Thr Val Asn Lys Pro Val Val Gly Val Leu Met Gly Phe Gly 
1               5                   10                  15      


Ile Ile Thr Gly Thr Leu Arg Ile Thr Asn Pro Val Arg Ala Ser Val 
            20                  25                  30          


Leu Arg Tyr Asp Asp Phe His Thr Asp Glu Asp Lys Leu Asp Thr Asn 
        35                  40                  45              


Ser Val Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp 
    50                  55                  60                  


Val Asn Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro 
65                  70                  75                  80  


Tyr Ile Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His 
                85                  90                  95      


Glu His His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu 
            100                 105                 110         


Arg Leu Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp 
        115                 120                 125             


Asp Thr Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His 
    130                 135                 140                 


Lys Ile Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly 
145                 150                 155                 160 


Asp Leu Asn Pro Lys Pro Gln Gly Gln Arg Leu Ile Glu Val Ser Val 
                165                 170                 175     


Glu Glu Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr 
            180                 185                 190         


Gly Val Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys 
        195                 200                 205             


Thr Gly Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr 
    210                 215                 220                 


Thr Cys Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr 
225                 230                 235                 240 


Lys Glu Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys 
                245                 250                 255     


Glu Ala Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp 
            260                 265                 270         


Glu Leu Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val 
        275                 280                 285             


Leu Arg Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg 
    290                 295                 300                 


Gly Ser Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys 
305                 310                 315                 320 


Gly Asp Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro 
                325                 330                 335     


Arg Gly Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser 
            340                 345                 350         


Val Gly Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His 
        355                 360                 365             


Glu Ala Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp 
    370                 375                 380                 


Pro Thr Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro 
385                 390                 395                 400 


Asn Ala Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr 
                405                 410                 415     


Ser Pro His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys 
            420                 425                 430         


Glu His Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met 
        435                 440                 445             


Glu Pro Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys 
    450                 455                 460                 


Phe Val Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val 
465                 470                 475                 480 


Tyr Phe Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr 
                485                 490                 495     


Val Asp His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr 
            500                 505                 510         


Ala Gly Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val 
        515                 520                 525             


Asn Pro Gly Thr Ser Pro Leu Leu Arg Tyr Ala Ala Trp Thr Gly Gly 
    530                 535                 540                 


Leu Ala Ala Val Val Leu Leu Cys Leu Val Ile Phe Leu Ile Cys Thr 
545                 550                 555                 560 


Ala Lys Arg Met Arg Val Lys Ala Tyr Arg Val Asp Lys Ser Pro Tyr 
                565                 570                 575     


Asn Gln Ser Met Tyr Tyr Ala Gly Leu Pro Val Asp Asp Phe Glu Asp 
            580                 585                 590         


Ser Glu Ser Thr Asp Thr Glu Glu Glu Phe Gly Asn Ala Ile Gly Gly 
        595                 600                 605             


Ser His Gly Gly Ser Ser Tyr Thr Val Tyr Ile Asp Lys Thr Arg 
    610                 615                 620             


<210>  6
<211>  1872
<212>  DNA
<213>  Varicella Zoster Virus

<400>  6
atgggcaccg tgaacaagcc cgtggtgggc gtgctgatgg gtttcggtat catcaccggc       60

accctgcgta tcaccaaccc cgtgcgtgct tccgtgctgc gttacgacga cttccacacc      120

gacgaggaca agctggacac caactccgtg tacgagccct actaccactc cgaccacgct      180

gagtcctctt gggtgaaccg tggcgagtcc tcccgtaagg cttacgacca caactccccc      240

tacatctggc cccgtaacga ctacgacggt ttcctcgaga acgctcacga gcaccacggt      300

gtctacaacc agggtcgtgg tatcgactcc ggcgagcgtc tgatgcagcc cacccagatg      360

tccgctcagg aggacctggg cgacgacacc ggtatccacg tgatccccac cctgaacggt      420

gacgaccgtc acaagatcgt gaacgtggac cagcgccagt acggtgacgt gttcaagggt      480

gacctgaacc ccaagcccca gggccagcgt ctgatcgagg tgtccgtgga ggagaaccac      540

cccttcaccc tgcgtgctcc catccagcgt atctacggtg tccgttacac cgagacctgg      600

tccttcctcc cctccctgac ctgcaccggt gacgctgctc ccgctatcca gcacatctgc      660

ctgaagcaca ccacctgctt ccaggacgtg gtggtggacg tggactgcgc tgagaacacc      720

aaggaggacc agctggctga gatctcctac aggttccagg gcaagaagga ggctgaccag      780

ccctggatcg tggtgaacac ctccaccctg ttcgacgagc tggagctgga cccccccgag      840

atcgagcccg gtgtcctgaa ggtgctgcgt accgagaagc agtacctggg cgtgtacatc      900

tggaacatgc gtggttccga cggcacctcc acctacgcta ccttcctcgt gacctggaag      960

ggtgacgaaa agacccgtaa ccccaccccc gctgtgaccc cccagccccg tggtgctgaa     1020

ttccatatgt ggaactacca ctctcacgtg ttctccgtgg gtgacacctt ctccctggct     1080

atgcacctgc agtacaagat ccacgaggct cccttcgacc tgctgctcga gtggctgtac     1140

gtgcccatcg accccacctg ccagcccatg cgcctgtact ccacctgcct gtaccacccc     1200

aacgctcccc agtgcctgtc ccacatgaac tccggttgca ccttcacctc cccccacctg     1260

gcccagcgtg tggcttccac cgtgtaccag aactgcgagc acgctgacaa ctacaccgct     1320

tactgcctgg gtatcagcca catggagcct tccttcggtc tgatcctgca cgacggtggc     1380

accaccctga agttcgtgga cacccccgag tccctgtccg gtctgtacgt gttcgtggtg     1440

tacttcaacg gtcacgtgga ggctgtcgct tacaccgtgg tgtccaccgt ggaccacttc     1500

gtgaacgcta tcgaggagcg tggtttcccc cccaccgctg gccagccccc tgctaccacc     1560

aagcccaagg agatcacccc cgtcaacccc ggcacctccc ctctgctgcg ctacgctgct     1620

tggaccggtg gtctggctgc tgtggtgctg ctgtgcctgg tgatcttcct gatctgcacc     1680

gctaagagga tgcgtgtgaa ggcttaccgt gtggacaagt ccccttacaa ccagtccatg     1740

tactacgctg gtctgcccgt cgacgacttc gaggactccg agtccaccga caccgaggag     1800

gagttcggta acgctatcgg tggttcccac ggtggttcct cctacaccgt gtacatcgac     1860

aagacccgct aa                                                         1872


<210>  7
<211>  354
<212>  PRT
<213>  Varicella Zoster Virus

<400>  7

Met Phe Leu Ile Gln Cys Leu Ile Ser Ala Val Ile Phe Tyr Ile Gln 
1               5                   10                  15      


Val Thr Asn Ala Leu Ile Phe Lys Gly Asp His Val Ser Leu Gln Val 
            20                  25                  30          


Asn Ser Ser Leu Thr Ser Ile Leu Ile Pro Met Gln Asn Asp Asn Tyr 
        35                  40                  45              


Thr Glu Ile Lys Gly Gln Leu Val Phe Ile Gly Glu Gln Leu Pro Thr 
    50                  55                  60                  


Gly Thr Asn Tyr Ser Gly Thr Leu Glu Leu Leu Tyr Ala Asp Thr Val 
65                  70                  75                  80  


Ala Phe Cys Phe Arg Ser Val Gln Val Ile Arg Tyr Asp Gly Cys Pro 
                85                  90                  95      


Arg Ile Arg Thr Ser Ala Phe Ile Ser Cys Arg Tyr Lys His Ser Trp 
            100                 105                 110         


His Tyr Gly Asn Ser Thr Asp Arg Ile Ser Thr Glu Pro Asp Ala Gly 
        115                 120                 125             


Val Met Leu Lys Ile Thr Lys Pro Gly Ile Asn Asp Ala Gly Val Tyr 
    130                 135                 140                 


Val Leu Leu Val Arg Leu Asp His Ser Arg Ser Thr Asp Gly Phe Ile 
145                 150                 155                 160 


Leu Gly Val Asn Val Tyr Thr Ala Gly Ser His His Asn Ile His Gly 
                165                 170                 175     


Val Ile Tyr Thr Ser Pro Ser Leu Gln Asn Gly Tyr Ser Thr Arg Ala 
            180                 185                 190         


Leu Phe Gln Gln Ala Arg Leu Cys Asp Leu Pro Ala Thr Pro Lys Gly 
        195                 200                 205             


Ser Gly Thr Ser Leu Phe Gln His Met Leu Asp Leu Arg Ala Gly Lys 
    210                 215                 220                 


Ser Leu Glu Asp Asn Pro Trp Leu His Glu Asp Val Val Thr Thr Glu 
225                 230                 235                 240 


Thr Lys Ser Val Val Lys Glu Gly Ile Glu Asn His Val Tyr Pro Thr 
                245                 250                 255     


Asp Met Ser Thr Leu Pro Glu Lys Ser Leu Asn Asp Pro Pro Glu Asn 
            260                 265                 270         


Leu Leu Ile Ile Ile Pro Ile Val Ala Ser Val Met Ile Leu Thr Ala 
        275                 280                 285             


Met Val Ile Val Ile Val Ile Ser Val Lys Arg Arg Arg Ile Lys Lys 
    290                 295                 300                 


His Pro Ile Tyr Arg Pro Asn Thr Lys Thr Arg Arg Gly Ile Gln Asn 
305                 310                 315                 320 


Ala Thr Pro Glu Ser Asp Val Met Leu Glu Ala Ala Ile Ala Gln Leu 
                325                 330                 335     


Ala Thr Ile Arg Glu Glu Ser Pro Pro His Ser Val Val Asn Pro Phe 
            340                 345                 350         


Val Lys 
        


<210>  8
<211>  1065
<212>  DNA
<213>  Varicella Zoster Virus

<400>  8
atgttcctca tccagtgcct gatctccgct gtgatcttct acatccaagt gaccaacgct       60

ctgatcttca agggtgacca cgtgtccctg caggtcaact cctccctgac ctccatcctg      120

atccccatgc agaacgacaa ctacaccgag atcaagggcc agctggtgtt catcggcgag      180

cagctgccca ccggcaccaa ctactccggc accctcgagc tgctgtacgc tgacaccgtc      240

gctttctgct tccgttccgt gcaggtgatc cgttacgacg gttgcccccg tatccgtacc      300

tccgctttca tctcctgccg ttacaagcac tcctggcact acggtaactc caccgaccgt      360

atctccaccg agcccgacgc tggtgtcatg ctgaagatca ccaagcccgg tatcaacgac      420

gctggcgtgt acgtgctgct ggtccgtctg gaccactccc gttccaccga cggtttcatc      480

ctgggtgtca acgtgtacac cgctggttcc caccacaaca tccacggtgt catctacacc      540

tccccctccc tgcagaacgg ttactccacc cgtgctctgt tccagcaggc tcgtctgtgc      600

gacctgcccg ctacccccaa gggttccggc acctccctct tccagcacat gctggacctg      660

cgtgctggca agtccctcga ggacaacccc tggctgcacg aggacgtggt gaccaccgag      720

accaagtccg tggtgaagga aggtatcgag aaccacgtgt accccaccga catgtccacc      780

ctgcccgaga agtccctgaa cgaccccccc gagaacctgc tgatcatcat ccccatcgtg      840

gcttccgtga tgatcctgac cgctatggtg atcgtgatcg tcatctccgt gaagcgtcgt      900

cgtatcaaga agcaccccat ctaccgtccc aacaccaaga cccgtcgtgg tatccagaac      960

gctacccccg agtccgacgt gatgctcgag gctgctatcg cccagctggc taccatccgt     1020

gaggaatccc cccctcactc cgtggtcaac cccttcgtga agtaa                     1065


<210>  9
<211>  252
<212>  PRT
<213>  Influenza Virus

<400>  9

Met Ser Leu Leu Thr Glu Val Glu Thr Tyr Val Leu Ser Ile Ile Pro 
1               5                   10                  15      


Ser Gly Pro Leu Lys Ala Glu Ile Ala Gln Lys Leu Glu Asp Val Phe 
            20                  25                  30          


Ala Gly Lys Asn Thr Asp Leu Glu Ala Leu Met Glu Trp Leu Lys Thr 
        35                  40                  45              


Arg Pro Ile Leu Ser Pro Leu Thr Lys Gly Ile Leu Gly Phe Val Phe 
    50                  55                  60                  


Thr Leu Thr Val Pro Ser Glu Arg Gly Leu Gln Arg Arg Arg Phe Val 
65                  70                  75                  80  


Gln Asn Ala Leu Asn Gly Asn Gly Asp Pro Asn Asn Met Asp Arg Ala 
                85                  90                  95      


Val Lys Leu Tyr Lys Lys Leu Lys Arg Glu Ile Thr Phe His Gly Ala 
            100                 105                 110         


Lys Glu Val Ser Leu Ser Tyr Ser Thr Gly Ala Leu Ala Ser Cys Met 
        115                 120                 125             


Gly Leu Ile Tyr Asn Arg Met Gly Thr Val Thr Thr Glu Val Ala Phe 
    130                 135                 140                 


Gly Leu Val Cys Ala Thr Cys Glu Gln Ile Ala Asp Ser Gln His Arg 
145                 150                 155                 160 


Ser His Arg Gln Met Ala Thr Ile Thr Asn Pro Leu Ile Arg His Glu 
                165                 170                 175     


Asn Arg Met Val Leu Ala Ser Thr Thr Ala Lys Ala Met Glu Gln Met 
            180                 185                 190         


Ala Gly Ser Ser Glu Gln Ala Ala Glu Ala Met Glu Val Ala Asn Gln 
        195                 200                 205             


Ala Arg Gln Met Val Gln Ala Met Arg Thr Ile Gly Thr His Pro Asn 
    210                 215                 220                 


Ser Ser Ala Gly Leu Arg Asp Asn Leu Leu Glu Asn Leu Gln Ala Tyr 
225                 230                 235                 240 


Gln Lys Arg Met Gly Val Gln Met Gln Arg Phe Lys 
                245                 250         


<210>  10
<211>  535
<212>  PRT
<213>  Varicella Zoster Virus

<400>  10

Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala Ala His 
1               5                   10                  15      


Ser Ala Phe Ala Arg Ile Thr Asn Pro Val Arg Ala Ser Val Leu Arg 
            20                  25                  30          


Tyr Asp Asp Phe His Thr Asp Glu Asp Lys Leu Asp Thr Asn Ser Val 
        35                  40                  45              


Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp Val Asn 
    50                  55                  60                  


Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro Tyr Ile 
65                  70                  75                  80  


Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His Glu His 
                85                  90                  95      


His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu Arg Leu 
            100                 105                 110         


Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp Asp Thr 
        115                 120                 125             


Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His Lys Ile 
    130                 135                 140                 


Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly Asp Leu 
145                 150                 155                 160 


Asn Pro Lys Pro Gln Gly Gln Arg Leu Ile Glu Val Ser Val Glu Glu 
                165                 170                 175     


Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr Gly Val 
            180                 185                 190         


Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys Thr Gly 
        195                 200                 205             


Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr Thr Cys 
    210                 215                 220                 


Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr Lys Glu 
225                 230                 235                 240 


Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys Glu Ala 
                245                 250                 255     


Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp Glu Leu 
            260                 265                 270         


Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val Leu Arg 
        275                 280                 285             


Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg Gly Ser 
    290                 295                 300                 


Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys Gly Asp 
305                 310                 315                 320 


Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro Arg Gly 
                325                 330                 335     


Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser Val Gly 
            340                 345                 350         


Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His Glu Ala 
        355                 360                 365             


Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp Pro Thr 
    370                 375                 380                 


Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro Asn Ala 
385                 390                 395                 400 


Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr Ser Pro 
                405                 410                 415     


His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys Glu His 
            420                 425                 430         


Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met Glu Pro 
        435                 440                 445             


Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys Phe Val 
    450                 455                 460                 


Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val Tyr Phe 
465                 470                 475                 480 


Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr Val Asp 
                485                 490                 495     


His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr Ala Gly 
            500                 505                 510         


Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val Asn Pro 
        515                 520                 525             


Gly Thr Ser Pro Leu Leu Arg 
    530                 535 


<210>  11
<211>  1608
<212>  DNA
<213>  Varicella Zoster Virus

<400>  11
atggtgtccg ctatcgtgct gtacgtgctg ctggctgctg ctgctcactc cgctttcgct       60

cgtatcacca accccgtgcg tgcttccgtg ctgcgttacg acgacttcca caccgacgag      120

gacaagctgg acaccaactc cgtgtacgag ccctactacc actccgacca cgctgagtcc      180

tcttgggtga accgtggcga gtcctcccgt aaggcttacg accacaactc cccctacatc      240

tggccccgta acgactacga cggtttcctc gagaacgctc acgagcacca cggtgtctac      300

aaccagggtc gtggtatcga ctccggcgag cgtctgatgc agcccaccca gatgtccgct      360

caggaggacc tgggcgacga caccggtatc cacgtgatcc ccaccctgaa cggtgacgac      420

cgtcacaaga tcgtgaacgt ggaccagcgc cagtacggtg acgtgttcaa gggtgacctg      480

aaccccaagc cccagggcca gcgtctgatc gaggtgtccg tggaggagaa ccaccccttc      540

accctgcgtg ctcccatcca gcgtatctac ggtgtccgtt acaccgagac ctggtccttc      600

ctcccctccc tgacctgcac cggtgacgct gctcccgcta tccagcacat ctgcctgaag      660

cacaccacct gcttccagga cgtggtggtg gacgtggact gcgctgagaa caccaaggag      720

gaccagctgg ctgagatctc ctacaggttc cagggcaaga aggaggctga ccagccctgg      780

atcgtggtga acacctccac cctgttcgac gagctggagc tggacccccc cgagatcgag      840

cccggtgtcc tgaaggtgct gcgtaccgag aagcagtacc tgggcgtgta catctggaac      900

atgcgtggtt ccgacggcac ctccacctac gctaccttcc tcgtgacctg gaagggtgac      960

gaaaagaccc gtaaccccac ccccgctgtg accccccagc cccgtggtgc tgaattccat     1020

atgtggaact accactctca cgtgttctcc gtgggtgaca ccttctccct ggctatgcac     1080

ctgcagtaca agatccacga ggctcccttc gacctgctgc tcgagtggct gtacgtgccc     1140

atcgacccca cctgccagcc catgcgcctg tactccacct gcctgtacca ccccaacgct     1200

ccccagtgcc tgtcccacat gaactccggt tgcaccttca cctcccccca cctggcccag     1260

cgtgtggctt ccaccgtgta ccagaactgc gagcacgctg acaactacac cgcttactgc     1320

ctgggtatca gccacatgga gccttccttc ggtctgatcc tgcacgacgg tggcaccacc     1380

ctgaagttcg tggacacccc cgagtccctg tccggtctgt acgtgttcgt ggtgtacttc     1440

aacggtcacg tggaggctgt cgcttacacc gtggtgtcca ccgtggacca cttcgtgaac     1500

gctatcgagg agcgtggttt cccccccacc gctggccagc cccctgctac caccaagccc     1560

aaggagatca cccccgtcaa ccccggcacc tcccctctgc tgcgctaa                  1608


<210>  12
<211>  271
<212>  PRT
<213>  Varicella Zoster Virus

<400>  12

Met Phe Leu Ile Gln Cys Leu Ile Ser Ala Val Ile Phe Tyr Ile Gln 
1               5                   10                  15      


Val Thr Asn Ala Leu Ile Phe Lys Gly Asp His Val Ser Leu Gln Val 
            20                  25                  30          


Asn Ser Ser Leu Thr Ser Ile Leu Ile Pro Met Gln Asn Asp Asn Tyr 
        35                  40                  45              


Thr Glu Ile Lys Gly Gln Leu Val Phe Ile Gly Glu Gln Leu Pro Thr 
    50                  55                  60                  


Gly Thr Asn Tyr Ser Gly Thr Leu Glu Leu Leu Tyr Ala Asp Thr Val 
65                  70                  75                  80  


Ala Phe Cys Phe Arg Ser Val Gln Val Ile Arg Tyr Asp Gly Cys Pro 
                85                  90                  95      


Arg Ile Arg Thr Ser Ala Phe Ile Ser Cys Arg Tyr Lys His Ser Trp 
            100                 105                 110         


His Tyr Gly Asn Ser Thr Asp Arg Ile Ser Thr Glu Pro Asp Ala Gly 
        115                 120                 125             


Val Met Leu Lys Ile Thr Lys Pro Gly Ile Asn Asp Ala Gly Val Tyr 
    130                 135                 140                 


Val Leu Leu Val Arg Leu Asp His Ser Arg Ser Thr Asp Gly Phe Ile 
145                 150                 155                 160 


Leu Gly Val Asn Val Tyr Thr Ala Gly Ser His His Asn Ile His Gly 
                165                 170                 175     


Val Ile Tyr Thr Ser Pro Ser Leu Gln Asn Gly Tyr Ser Thr Arg Ala 
            180                 185                 190         


Leu Phe Gln Gln Ala Arg Leu Cys Asp Leu Pro Ala Thr Pro Lys Gly 
        195                 200                 205             


Ser Gly Thr Ser Leu Phe Gln His Met Leu Asp Leu Arg Ala Gly Lys 
    210                 215                 220                 


Ser Leu Glu Asp Asn Pro Trp Leu His Glu Asp Val Val Thr Thr Glu 
225                 230                 235                 240 


Thr Lys Ser Val Val Lys Glu Gly Ile Glu Asn His Val Tyr Pro Thr 
                245                 250                 255     


Asp Met Ser Thr Leu Pro Glu Lys Ser Leu Asn Asp Pro Pro Glu 
            260                 265                 270     


<210>  13
<211>  816
<212>  DNA
<213>  Varicella Zoster Virus

<400>  13
atgttcctca tccagtgcct gatctccgct gtgatcttct acatccaagt gaccaacgct       60

ctgatcttca agggtgacca cgtgtccctg caggtcaact cctccctgac ctccatcctg      120

atccccatgc agaacgacaa ctacaccgag atcaagggcc agctggtgtt catcggcgag      180

cagctgccca ccggcaccaa ctactccggc accctcgagc tgctgtacgc tgacaccgtc      240

gctttctgct tccgttccgt gcaggtgatc cgttacgacg gttgcccccg tatccgtacc      300

tccgctttca tctcctgccg ttacaagcac tcctggcact acggtaactc caccgaccgt      360

atctccaccg agcccgacgc tggtgtcatg ctgaagatca ccaagcccgg tatcaacgac      420

gctggcgtgt acgtgctgct ggtccgtctg gaccactccc gttccaccga cggtttcatc      480

ctgggtgtca acgtgtacac cgctggttcc caccacaaca tccacggtgt catctacacc      540

tccccctccc tgcagaacgg ttactccacc cgtgctctgt tccagcaggc tcgtctgtgc      600

gacctgcccg ctacccccaa gggttccggc acctccctct tccagcacat gctggacctg      660

cgtgctggca agtccctcga ggacaacccc tggctgcacg aggacgtggt gaccaccgag      720

accaagtccg tggtgaagga aggtatcgag aaccacgtgt accccaccga catgtccacc      780

ctgcccgaga agtccctgaa cgaccccccc gagtaa                                816


