                         SEQUENCE LISTING

<110>  Novavax, Inc.
 
<120>  Varicella Zoster Virus VLPs

<130>  NOVV-019/01WO

<150>  US 60/950,707
<151>  2007-07-19

<160>  20    

<170>  PatentIn version 3.5

<210>  1
<211>  435
<212>  PRT
<213>  Varicella Zoster Virus

<400>  1

Met Gly Thr Gln Lys Lys Gly Pro Arg Ser Glu Lys Val Ser Pro Tyr 
1               5                   10                  15      


Asp Thr Thr Thr Pro Glu Val Glu Ala Leu Asp His Gln Met Asp Thr 
            20                  25                  30          


Leu Asn Trp Arg Ile Trp Ile Ile Gln Val Met Met Phe Thr Leu Gly 
        35                  40                  45              


Ala Val Met Leu Leu Ala Thr Leu Ile Ala Ala Ser Ser Glu Tyr Thr 
    50                  55                  60                  


Gly Ile Pro Cys Phe Tyr Ala Ala Val Val Asp Tyr Glu Leu Phe Asn 
65                  70                  75                  80  


Ala Thr Leu Asp Gly Gly Val Trp Ser Gly Asn Arg Gly Gly Tyr Ser 
                85                  90                  95      


Ala Pro Val Leu Phe Leu Glu Pro His Ser Val Val Ala Phe Thr Tyr 
            100                 105                 110         


Tyr Thr Ala Leu Thr Ala Met Ala Met Ala Val Tyr Thr Leu Ile Thr 
        115                 120                 125             


Ala Ala Ile Ile His Arg Glu Thr Lys Asn Gln Arg Val Arg Gln Ser 
    130                 135                 140                 


Ser Gly Val Ala Trp Leu Val Val Asp Pro Thr Thr Leu Phe Trp Gly 
145                 150                 155                 160 


Leu Leu Ser Leu Trp Leu Leu Asn Ala Val Val Leu Leu Leu Ala Tyr 
                165                 170                 175     


Lys Gln Ile Gly Val Ala Ala Thr Leu Tyr Leu Gly His Phe Ala Thr 
            180                 185                 190         


Ser Val Ile Phe Thr Thr Tyr Phe Cys Gly Arg Gly Lys Leu Asp Glu 
        195                 200                 205             


Thr Asn Ile Lys Ala Val Ala Asn Leu Arg Gln Gln Ser Val Phe Leu 
    210                 215                 220                 


Tyr Arg Leu Ala Gly Pro Thr Arg Ala Val Phe Val Asn Leu Met Ala 
225                 230                 235                 240 


Ala Leu Met Ala Ile Cys Ile Leu Phe Val Ser Leu Met Leu Glu Leu 
                245                 250                 255     


Val Val Ala Asn His Leu His Thr Gly Leu Trp Ser Ser Val Ser Val 
            260                 265                 270         


Ala Met Ser Thr Phe Ser Thr Leu Ser Val Val Tyr Leu Ile Val Ser 
        275                 280                 285             


Glu Leu Ile Leu Ala His Tyr Ile His Val Leu Ile Gly Pro Ser Leu 
    290                 295                 300                 


Gly Thr Leu Val Ala Cys Ala Thr Leu Gly Thr Ala Ala His Ser Tyr 
305                 310                 315                 320 


Met Asp Arg Leu Tyr Asp Pro Ile Ser Val Gln Ser Pro Arg Leu Ile 
                325                 330                 335     


Pro Thr Thr Arg Gly Thr Leu Ala Cys Leu Ala Val Phe Ser Val Val 
            340                 345                 350         


Met Leu Leu Leu Arg Leu Met Arg Ala Tyr Val Tyr His Arg Gln Lys 
        355                 360                 365             


Arg Ser Arg Phe Tyr Gly Ala Val Arg Arg Val Pro Glu Arg Val Arg 
    370                 375                 380                 


Gly Tyr Ile Arg Lys Val Lys Pro Ala His Arg Asn Ser Arg Arg Thr 
385                 390                 395                 400 


Asn Tyr Pro Ser Gln Gly Tyr Gly Tyr Val Tyr Glu Asn Asp Ser Thr 
                405                 410                 415     


Tyr Glu Thr Asp Arg Glu Asp Glu Leu Leu Tyr Glu Arg Ser Asn Ser 
            420                 425                 430         


Gly Trp Glu 
        435 


<210>  2
<211>  1310
<212>  PRT
<213>  Varicella Zoster Virus

<400>  2

Met Asp Thr Pro Pro Met Gln Arg Ser Thr Pro Gln Arg Ala Gly Ser 
1               5                   10                  15      


Pro Asp Thr Leu Glu Leu Met Asp Leu Leu Asp Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Glu His Arg Ala Arg Val Val Thr Ser Ser Gln Pro Asp Asp Leu 
        35                  40                  45              


Leu Phe Gly Glu Asn Gly Val Met Val Gly Arg Glu His Glu Ile Val 
    50                  55                  60                  


Ser Ile Pro Ser Val Ser Gly Leu Gln Pro Glu Pro Arg Thr Glu Asp 
65                  70                  75                  80  


Val Gly Glu Glu Leu Thr Gln Asp Asp Tyr Val Cys Glu Asp Gly Gln 
                85                  90                  95      


Asp Leu Met Gly Ser Pro Val Ile Pro Leu Ala Glu Val Phe His Thr 
            100                 105                 110         


Arg Phe Ser Glu Ala Gly Ala Arg Glu Pro Thr Gly Ala Asp Arg Ser 
        115                 120                 125             


Leu Glu Thr Val Ser Leu Gly Thr Lys Leu Ala Arg Ser Pro Lys Pro 
    130                 135                 140                 


Pro Met Asn Asp Gly Glu Thr Gly Arg Gly Thr Thr Pro Pro Phe Pro 
145                 150                 155                 160 


Gln Ala Phe Ser Pro Val Ser Pro Ala Ser Pro Val Gly Asp Ala Ala 
                165                 170                 175     


Gly Asn Asp Gln Arg Glu Asp Gln Arg Ser Ile Pro Arg Gln Thr Thr 
            180                 185                 190         


Arg Gly Asn Ser Pro Gly Leu Pro Ser Val Val His Arg Asp Arg Gln 
        195                 200                 205             


Thr Gln Ser Ile Ser Gly Lys Lys Pro Gly Asp Glu Gln Ala Gly His 
    210                 215                 220                 


Ala His Ala Ser Gly Asp Gly Val Val Leu Gln Lys Thr Gln Arg Pro 
225                 230                 235                 240 


Ala Gln Gly Lys Ser Pro Lys Lys Lys Thr Leu Lys Val Lys Val Pro 
                245                 250                 255     


Leu Pro Ala Arg Lys Pro Gly Gly Pro Val Pro Gly Pro Val Glu Gln 
            260                 265                 270         


Leu Tyr His Val Leu Ser Asp Ser Val Pro Ala Lys Gly Ala Lys Ala 
        275                 280                 285             


Asp Leu Pro Phe Glu Thr Asp Asp Thr Arg Pro Arg Lys His Asp Ala 
    290                 295                 300                 


Arg Gly Ile Thr Pro Arg Val Pro Gly Arg Ser Ser Gly Gly Lys Pro 
305                 310                 315                 320 


Arg Ala Phe Leu Ala Leu Pro Gly Arg Ser His Ala Pro Asp Pro Ile 
                325                 330                 335     


Glu Asp Asp Ser Pro Val Glu Lys Lys Pro Lys Ser Arg Glu Phe Val 
            340                 345                 350         


Ser Ser Ser Ser Ser Ser Ser Ser Trp Gly Ser Ser Ser Glu Asp Glu 
        355                 360                 365             


Asp Asp Glu Pro Arg Arg Val Ser Val Gly Ser Glu Thr Thr Gly Ser 
    370                 375                 380                 


Arg Ser Gly Arg Glu His Ala Pro Ser Pro Ser Asn Ser Asp Asp Ser 
385                 390                 395                 400 


Asp Ser Asn Asp Gly Gly Ser Thr Lys Gln Asn Ile Gln Pro Gly Tyr 
                405                 410                 415     


Arg Ser Ile Ser Gly Pro Asp Pro Arg Ile Arg Lys Thr Lys Arg Leu 
            420                 425                 430         


Ala Gly Glu Pro Gly Arg Gln Arg Gln Lys Ser Phe Ser Leu Pro Arg 
        435                 440                 445             


Ser Arg Thr Pro Ile Ile Pro Pro Val Ser Gly Pro Leu Met Met Pro 
    450                 455                 460                 


Asp Gly Ser Pro Trp Pro Gly Ser Ala Pro Leu Pro Ser Asn Arg Val 
465                 470                 475                 480 


Arg Phe Gly Pro Ser Gly Glu Thr Arg Glu Gly His Trp Glu Asp Glu 
                485                 490                 495     


Ala Val Arg Ala Ala Arg Ala Arg Tyr Glu Ala Ser Thr Glu Pro Val 
            500                 505                 510         


Pro Leu Tyr Val Pro Glu Leu Gly Asp Pro Ala Arg Gln Tyr Arg Ala 
        515                 520                 525             


Leu Ile Asn Leu Ile Tyr Cys Pro Asp Arg Asp Pro Ile Ala Trp Leu 
    530                 535                 540                 


Gln Asn Pro Lys Leu Thr Gly Val Asn Ser Ala Leu Asn Gln Phe Tyr 
545                 550                 555                 560 


Gln Lys Leu Leu Pro Pro Gly Arg Ala Gly Thr Ala Val Thr Gly Ser 
                565                 570                 575     


Val Ala Ser Pro Val Pro His Val Gly Glu Ala Met Ala Thr Gly Glu 
            580                 585                 590         


Ala Leu Trp Ala Leu Pro His Ala Ala Ala Ala Val Ala Met Ser Arg 
        595                 600                 605             


Arg Tyr Asp Arg Ala Gln Lys His Phe Ile Leu Gln Ser Leu Arg Arg 
    610                 615                 620                 


Ala Phe Ala Ser Met Ala Tyr Pro Glu Ala Thr Gly Ser Ser Pro Ala 
625                 630                 635                 640 


Ala Arg Ile Ser Arg Gly His Pro Ser Pro Thr Thr Pro Ala Thr Gln 
                645                 650                 655     


Ala Pro Asp Pro Gln Pro Ser Ala Ala Ala Arg Ser Leu Ser Val Cys 
            660                 665                 670         


Pro Pro Asp Asp Arg Leu Arg Thr Pro Arg Lys Arg Lys Ser Gln Pro 
        675                 680                 685             


Val Glu Ser Arg Ser Leu Leu Asp Lys Ile Arg Glu Thr Pro Val Ala 
    690                 695                 700                 


Asp Ala Arg Val Ala Asp Asp His Val Val Ser Lys Ala Lys Arg Arg 
705                 710                 715                 720 


Val Ser Glu Pro Val Thr Ile Thr Ser Gly Pro Val Val Asp Pro Pro 
                725                 730                 735     


Ala Val Ile Thr Met Pro Leu Asp Gly Pro Ala Pro Asn Gly Gly Phe 
            740                 745                 750         


Arg Arg Ile Pro Arg Gly Ala Leu His Thr Pro Val Pro Ser Asp Gln 
        755                 760                 765             


Ala Arg Lys Ala Tyr Cys Thr Pro Glu Thr Ile Ala Arg Leu Val Asp 
    770                 775                 780                 


Asp Pro Leu Phe Pro Thr Ala Trp Arg Pro Ala Leu Ser Phe Asp Pro 
785                 790                 795                 800 


Gly Ala Leu Ala Glu Ile Ala Ala Arg Arg Pro Gly Gly Gly Asp Arg 
                805                 810                 815     


Arg Phe Gly Pro Pro Ser Gly Val Glu Ala Leu Arg Arg Arg Cys Ala 
            820                 825                 830         


Trp Met Arg Gln Ile Pro Asp Pro Glu Asp Val Arg Leu Leu Ile Ile 
        835                 840                 845             


Tyr Asp Pro Leu Pro Gly Glu Asp Ile Asn Gly Pro Leu Glu Ser Thr 
    850                 855                 860                 


Leu Ala Thr Asp Pro Gly Pro Ser Trp Ser Pro Ser Arg Gly Gly Leu 
865                 870                 875                 880 


Ser Val Val Leu Ala Ala Leu Ser Asn Arg Leu Cys Leu Pro Ser Thr 
                885                 890                 895     


His Ala Trp Ala Gly Asn Trp Thr Gly Pro Pro Asp Val Ser Ala Leu 
            900                 905                 910         


Asn Ala Arg Gly Val Leu Leu Leu Ser Thr Arg Asp Leu Ala Phe Ala 
        915                 920                 925             


Gly Ala Val Glu Tyr Leu Gly Ser Arg Leu Ala Ser Ala Arg Arg Arg 
    930                 935                 940                 


Leu Leu Val Leu Asp Ala Val Ala Leu Glu Arg Trp Pro Arg Asp Gly 
945                 950                 955                 960 


Pro Ala Leu Ser Gln Tyr His Val Tyr Val Arg Ala Pro Ala Arg Pro 
                965                 970                 975     


Asp Ala Gln Ala Val Val Arg Trp Pro Asp Ser Ala Val Thr Glu Gly 
            980                 985                 990         


Leu Ala Arg Ala Val Phe Ala Ser  Ser Arg Thr Phe Gly  Pro Ala Ser 
        995                 1000                 1005             


Phe Ala  Arg Ile Glu Thr Ala  Phe Ala Asn Leu Tyr  Pro Gly Glu 
    1010                 1015                 1020             


Gln Pro  Leu Cys Leu Cys Arg  Gly Gly Asn Val Ala  Tyr Thr Val 
    1025                 1030                 1035             


Cys Thr  Arg Ala Gly Pro Lys  Thr Arg Val Pro Leu  Ser Pro Arg 
    1040                 1045                 1050             


Glu Tyr  Arg Gln Tyr Val Leu  Pro Gly Phe Asp Gly  Cys Lys Asp 
    1055                 1060                 1065             


Leu Ala  Arg Gln Ser Arg Gly  Leu Gly Leu Gly Ala  Ala Asp Phe 
    1070                 1075                 1080             


Val Asp  Glu Ala Ala His Ser  His Arg Ala Ala Asn  Arg Trp Gly 
    1085                 1090                 1095             


Leu Gly  Ala Ala Leu Arg Pro  Val Phe Leu Pro Glu  Gly Arg Arg 
    1100                 1105                 1110             


Pro Gly  Ala Ala Gly Pro Glu  Ala Gly Asp Val Pro  Thr Trp Ala 
    1115                 1120                 1125             


Arg Val  Phe Cys Arg His Ala  Leu Leu Glu Pro Asp  Pro Ala Ala 
    1130                 1135                 1140             


Glu Pro  Leu Val Leu Pro Pro  Val Ala Gly Arg Ser  Val Ala Leu 
    1145                 1150                 1155             


Tyr Ala  Ser Ala Asp Glu Ala  Arg Asn Ala Leu Pro  Pro Ile Pro 
    1160                 1165                 1170             


Arg Val  Met Trp Pro Pro Gly  Phe Gly Ala Ala Glu  Thr Val Leu 
    1175                 1180                 1185             


Glu Gly  Ser Asp Gly Thr Arg  Phe Val Phe Gly His  His Gly Gly 
    1190                 1195                 1200             


Ser Glu  Arg Pro Ser Glu Thr  Gln Ala Gly Arg Gln  Arg Arg Thr 
    1205                 1210                 1215             


Ala Asp  Asp Arg Glu His Ala  Leu Glu Leu Asp Asp  Trp Glu Val 
    1220                 1225                 1230             


Gly Cys  Glu Asp Ala Trp Asp  Ser Glu Glu Gly Gly  Gly Asp Asp 
    1235                 1240                 1245             


Gly Asp  Ala Pro Gly Ser Ser  Phe Gly Val Ser Ile  Val Ser Val 
    1250                 1255                 1260             


Ala Pro  Gly Val Leu Arg Asp  Arg Arg Val Gly Leu  Arg Pro Ala 
    1265                 1270                 1275             


Val Lys  Val Glu Leu Leu Ser  Ser Ser Ser Ser Ser  Glu Asp Glu 
    1280                 1285                 1290             


Asp Asp  Val Trp Gly Gly Arg  Gly Gly Arg Ser Pro  Pro Gln Ser 
    1295                 1300                 1305             


Arg Gly  
    1310 


<210>  3
<211>  278
<212>  PRT
<213>  Varicella Zoster Virus

<400>  3

Met Phe Cys Thr Ser Pro Ala Thr Arg Gly Asp Ser Ser Glu Ser Lys 
1               5                   10                  15      


Pro Gly Ala Ser Val Asp Val Asn Gly Lys Met Glu Tyr Gly Ser Ala 
            20                  25                  30          


Pro Gly Pro Leu Asn Gly Arg Asp Thr Ser Arg Gly Pro Gly Ala Phe 
        35                  40                  45              


Cys Thr Pro Gly Trp Glu Ile His Pro Ala Arg Leu Val Glu Asp Ile 
    50                  55                  60                  


Asn Arg Val Phe Leu Cys Ile Ala Gln Ser Ser Gly Arg Val Thr Arg 
65                  70                  75                  80  


Asp Ser Arg Arg Leu Arg Arg Ile Cys Leu Asp Phe Tyr Leu Met Gly 
                85                  90                  95      


Arg Thr Arg Gln Arg Pro Thr Leu Ala Cys Trp Glu Glu Leu Leu Gln 
            100                 105                 110         


Leu Gln Pro Thr Gln Thr Gln Cys Leu Arg Ala Thr Leu Met Glu Val 
        115                 120                 125             


Ser His Arg Pro Pro Arg Gly Glu Asp Gly Phe Ile Glu Ala Pro Asn 
    130                 135                 140                 


Val Pro Leu His Arg Ser Ala Leu Glu Cys Asp Val Ser Asp Asp Gly 
145                 150                 155                 160 


Gly Glu Asp Asp Ser Asp Asp Asp Gly Ser Thr Pro Ser Asp Val Ile 
                165                 170                 175     


Glu Phe Arg Asp Ser Asp Ala Glu Ser Ser Asp Gly Glu Asp Phe Ile 
            180                 185                 190         


Val Glu Glu Glu Ser Glu Glu Ser Thr Asp Ser Cys Glu Pro Asp Gly 
        195                 200                 205             


Val Pro Gly Asp Cys Tyr Arg Asp Gly Asp Gly Cys Asn Thr Pro Ser 
    210                 215                 220                 


Pro Lys Arg Pro Gln Arg Ala Ile Glu Arg Tyr Ala Gly Ala Glu Thr 
225                 230                 235                 240 


Ala Glu Tyr Thr Ala Ala Lys Ala Leu Thr Ala Leu Gly Glu Gly Gly 
                245                 250                 255     


Val Asp Trp Lys Arg Arg Arg His Glu Ala Pro Arg Arg His Asp Ile 
            260                 265                 270         


Pro Pro Pro His Gly Val 
        275             


<210>  4
<211>  302
<212>  PRT
<213>  Varicella Zoster Virus

<400>  4

Met Ala Ser Ser Asp Gly Asp Arg Leu Cys Arg Ser Asn Ala Val Arg 
1               5                   10                  15      


Arg Lys Thr Thr Pro Ser Tyr Ser Gly Gln Tyr Arg Thr Ala Arg Arg 
            20                  25                  30          


Ser Val Val Val Gly Pro Pro Asp Asp Ser Asp Asp Ser Leu Gly Tyr 
        35                  40                  45              


Ile Thr Thr Val Gly Ala Asp Ser Pro Ser Pro Val Tyr Ala Asp Leu 
    50                  55                  60                  


Tyr Phe Glu His Lys Asn Thr Thr Pro Arg Val His Gln Pro Asn Asp 
65                  70                  75                  80  


Ser Ser Gly Ser Glu Asp Asp Phe Glu Asp Ile Asp Glu Val Val Ala 
                85                  90                  95      


Ala Phe Arg Glu Ala Arg Leu Arg His Glu Leu Val Glu Asp Ala Val 
            100                 105                 110         


Tyr Glu Asn Pro Leu Ser Val Glu Lys Pro Ser Arg Ser Phe Thr Lys 
        115                 120                 125             


Asn Ala Ala Val Lys Pro Lys Leu Glu Asp Ser Pro Lys Arg Ala Pro 
    130                 135                 140                 


Pro Gly Ala Gly Ala Ile Ala Ser Gly Arg Pro Ile Ser Phe Ser Thr 
145                 150                 155                 160 


Ala Pro Lys Thr Ala Thr Ser Ser Trp Cys Gly Pro Thr Pro Ser Tyr 
                165                 170                 175     


Asn Lys Arg Val Phe Cys Glu Ala Val Arg Arg Val Ala Ala Met Gln 
            180                 185                 190         


Ala Gln Lys Ala Ala Glu Ala Ala Trp Asn Ser Asn Pro Pro Arg Asn 
        195                 200                 205             


Asn Ala Glu Leu Asp Arg Leu Leu Thr Gly Ala Val Ile Arg Ile Thr 
    210                 215                 220                 


Val His Glu Gly Leu Asn Leu Ile Gln Ala Ala Asn Glu Ala Asp Leu 
225                 230                 235                 240 


Gly Glu Gly Ala Ser Val Ser Lys Arg Gly His Asn Arg Lys Thr Gly 
                245                 250                 255     


Asp Leu Gln Gly Gly Met Gly Asn Glu Pro Met Tyr Ala Gln Val Arg 
            260                 265                 270         


Lys Pro Lys Ser Arg Thr Asp Thr Gln Thr Thr Gly Arg Ile Thr Asn 
        275                 280                 285             


Arg Ser Arg Ala Arg Ser Ala Ser Arg Thr Asp Thr Arg Lys 
    290                 295                 300         


<210>  5
<211>  410
<212>  PRT
<213>  Varicella Zoster Virus

<400>  5

Met Glu Cys Asn Leu Gly Thr Glu His Pro Ser Thr Asp Thr Trp Asn 
1               5                   10                  15      


Arg Ser Lys Thr Glu Gln Ala Val Val Asp Ala Phe Asp Glu Ser Leu 
            20                  25                  30          


Phe Gly Asp Val Ala Ser Asp Ile Gly Phe Glu Thr Ser Leu Tyr Ser 
        35                  40                  45              


His Ala Val Lys Thr Ala Pro Ser Pro Pro Trp Val Ala Ser Pro Lys 
    50                  55                  60                  


Ile Leu Tyr Gln Gln Leu Ile Arg Asp Leu Asp Phe Ser Glu Gly Pro 
65                  70                  75                  80  


Arg Leu Leu Ser Cys Leu Glu Thr Trp Asn Glu Asp Leu Phe Ser Cys 
                85                  90                  95      


Phe Pro Ile Asn Glu Asp Leu Tyr Ser Asp Met Met Val Leu Ser Pro 
            100                 105                 110         


Asp Pro Asp Asp Val Ile Ser Thr Val Ser Thr Lys Asp His Val Glu 
        115                 120                 125             


Met Phe Asn Leu Thr Thr Arg Gly Ser Val Arg Leu Pro Ser Pro Pro 
    130                 135                 140                 


Lys Gln Pro Thr Gly Leu Pro Ala Tyr Val Gln Glu Val Gln Asp Ser 
145                 150                 155                 160 


Phe Thr Val Glu Leu Arg Ala Arg Glu Glu Ala Tyr Thr Lys Leu Leu 
                165                 170                 175     


Val Thr Tyr Cys Lys Ser Ile Ile Arg Tyr Leu Gln Gly Thr Ala Lys 
            180                 185                 190         


Arg Thr Thr Ile Gly Leu Asn Ile Gln Asn Pro Asp Gln Lys Ala Tyr 
        195                 200                 205             


Thr Gln Leu Arg Gln Ser Ile Leu Leu Arg Tyr Tyr Arg Glu Val Ala 
    210                 215                 220                 


Ser Leu Ala Arg Leu Leu Tyr Leu His Leu Tyr Leu Thr Val Thr Arg 
225                 230                 235                 240 


Glu Phe Ser Trp Arg Leu Tyr Ala Ser Gln Ser Ala His Pro Asp Val 
                245                 250                 255     


Phe Ala Ala Leu Lys Phe Thr Trp Thr Glu Arg Arg Gln Phe Thr Cys 
            260                 265                 270         


Ala Phe His Pro Val Leu Cys Asn His Gly Ile Val Leu Leu Glu Gly 
        275                 280                 285             


Lys Pro Leu Thr Ala Ser Ala Leu Arg Glu Ile Asn Tyr Arg Arg Arg 
    290                 295                 300                 


Glu Leu Gly Leu Pro Leu Val Arg Cys Gly Leu Val Glu Glu Asn Lys 
305                 310                 315                 320 


Ser Pro Leu Val Gln Gln Pro Ser Phe Ser Val His Leu Pro Arg Ser 
                325                 330                 335     


Val Gly Phe Leu Thr His His Ile Lys Arg Lys Leu Asp Ala Tyr Ala 
            340                 345                 350         


Val Lys His Pro Gln Glu Pro Arg His Val Arg Ala Asp His Pro Tyr 
        355                 360                 365             


Ala Lys Val Val Glu Asn Arg Asn Tyr Gly Ser Ser Ile Glu Ala Met 
    370                 375                 380                 


Ile Leu Ala Pro Pro Ser Pro Ser Glu Ile Leu Pro Gly Asp Pro Pro 
385                 390                 395                 400 


Arg Pro Pro Thr Cys Gly Phe Leu Thr Arg 
                405                 410 


<210>  6
<211>  623
<212>  PRT
<213>  Varicella Zoster Virus

<400>  6

Met Gly Thr Val Asn Lys Pro Val Val Gly Val Leu Met Gly Phe Gly 
1               5                   10                  15      


Ile Ile Thr Gly Thr Leu Arg Ile Thr Asn Pro Val Arg Ala Ser Val 
            20                  25                  30          


Leu Arg Tyr Asp Asp Phe His Thr Asp Glu Asp Lys Leu Asp Thr Asn 
        35                  40                  45              


Ser Val Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp 
    50                  55                  60                  


Val Asn Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro 
65                  70                  75                  80  


Tyr Ile Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His 
                85                  90                  95      


Glu His His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu 
            100                 105                 110         


Arg Leu Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp 
        115                 120                 125             


Asp Thr Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His 
    130                 135                 140                 


Lys Ile Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly 
145                 150                 155                 160 


Asp Leu Asn Pro Lys Pro Gln Gly Gln Arg Leu Ile Glu Val Ser Val 
                165                 170                 175     


Glu Glu Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr 
            180                 185                 190         


Gly Val Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys 
        195                 200                 205             


Thr Gly Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr 
    210                 215                 220                 


Thr Cys Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr 
225                 230                 235                 240 


Lys Glu Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys 
                245                 250                 255     


Glu Ala Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp 
            260                 265                 270         


Glu Leu Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val 
        275                 280                 285             


Leu Arg Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg 
    290                 295                 300                 


Gly Ser Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys 
305                 310                 315                 320 


Gly Asp Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro 
                325                 330                 335     


Arg Gly Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser 
            340                 345                 350         


Val Gly Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His 
        355                 360                 365             


Glu Ala Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp 
    370                 375                 380                 


Pro Thr Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro 
385                 390                 395                 400 


Asn Ala Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr 
                405                 410                 415     


Ser Pro His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys 
            420                 425                 430         


Glu His Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met 
        435                 440                 445             


Glu Pro Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys 
    450                 455                 460                 


Phe Val Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val 
465                 470                 475                 480 


Tyr Phe Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr 
                485                 490                 495     


Val Asp His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr 
            500                 505                 510         


Ala Gly Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val 
        515                 520                 525             


Asn Pro Gly Thr Ser Pro Leu Leu Arg Tyr Ala Ala Trp Thr Gly Gly 
    530                 535                 540                 


Leu Ala Ala Val Val Leu Leu Cys Leu Val Ile Phe Leu Ile Cys Thr 
545                 550                 555                 560 


Ala Lys Arg Met Arg Val Lys Ala Tyr Arg Val Asp Lys Ser Pro Tyr 
                565                 570                 575     


Asn Gln Ser Met Tyr Tyr Ala Gly Leu Pro Val Asp Asp Phe Glu Asp 
            580                 585                 590         


Ser Glu Ser Thr Asp Thr Glu Glu Glu Phe Gly Asn Ala Ile Gly Gly 
        595                 600                 605             


Ser His Gly Gly Ser Ser Tyr Thr Val Tyr Ile Asp Lys Thr Arg 
    610                 615                 620             


<210>  7
<211>  575
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Orf68TCM variant of gE; transmembrane (TM) domain and COOH of gE 
       replaced with influenza A/Fujian TM domain and COOH

<400>  7

Met Gly Thr Val Asn Lys Pro Val Val Gly Val Leu Met Gly Phe Gly 
1               5                   10                  15      


Ile Ile Thr Gly Thr Leu Arg Ile Thr Asn Pro Val Arg Ala Ser Val 
            20                  25                  30          


Leu Arg Tyr Asp Asp Phe His Thr Asp Glu Asp Lys Leu Asp Thr Asn 
        35                  40                  45              


Ser Val Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp 
    50                  55                  60                  


Val Asn Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro 
65                  70                  75                  80  


Tyr Ile Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His 
                85                  90                  95      


Glu His His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu 
            100                 105                 110         


Arg Leu Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp 
        115                 120                 125             


Asp Thr Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His 
    130                 135                 140                 


Lys Ile Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly 
145                 150                 155                 160 


Asp Leu Asn Pro Lys Pro Gln Gly Gln Arg Leu Ile Glu Val Ser Val 
                165                 170                 175     


Glu Glu Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr 
            180                 185                 190         


Gly Val Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys 
        195                 200                 205             


Thr Gly Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr 
    210                 215                 220                 


Thr Cys Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr 
225                 230                 235                 240 


Lys Glu Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys 
                245                 250                 255     


Glu Ala Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp 
            260                 265                 270         


Glu Leu Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val 
        275                 280                 285             


Leu Arg Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg 
    290                 295                 300                 


Gly Ser Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys 
305                 310                 315                 320 


Gly Asp Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro 
                325                 330                 335     


Arg Gly Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser 
            340                 345                 350         


Val Gly Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His 
        355                 360                 365             


Glu Ala Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp 
    370                 375                 380                 


Pro Thr Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro 
385                 390                 395                 400 


Asn Ala Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr 
                405                 410                 415     


Ser Pro His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys 
            420                 425                 430         


Glu His Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met 
        435                 440                 445             


Glu Pro Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys 
    450                 455                 460                 


Phe Val Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val 
465                 470                 475                 480 


Tyr Phe Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr 
                485                 490                 495     


Val Asp His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr 
            500                 505                 510         


Ala Gly Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val 
        515                 520                 525             


Asn Pro Gly Thr Ser Pro Leu Leu Arg Asp Trp Ile Leu Trp Ile Ser 
    530                 535                 540                 


Phe Ala Ile Ser Cys Phe Leu Leu Cys Val Ala Leu Leu Gly Phe Ile 
545                 550                 555                 560 


Met Trp Ala Cys Gln Lys Gly Asn Ile Arg Cys Asn Ile Cys Ile 
                565                 570                 575 


<210>  8
<211>  841
<212>  PRT
<213>  Varicella Zoster Virus

<400>  8

Met Phe Ala Leu Val Leu Ala Val Val Ile Leu Pro Leu Trp Thr Thr 
1               5                   10                  15      


Ala Asn Lys Ser Tyr Val Thr Pro Thr Pro Ala Thr Arg Ser Ile Gly 
            20                  25                  30          


His Met Ser Ala Leu Leu Arg Glu Tyr Ser Asp Arg Asn Met Ser Leu 
        35                  40                  45              


Lys Leu Glu Ala Phe Tyr Pro Thr Gly Phe Asp Glu Glu Leu Ile Lys 
    50                  55                  60                  


Ser Leu His Trp Gly Asn Asp Arg Lys His Val Phe Leu Val Ile Val 
65                  70                  75                  80  


Lys Val Asn Pro Thr Thr His Glu Gly Asp Val Gly Leu Val Ile Phe 
                85                  90                  95      


Pro Lys Tyr Leu Leu Ser Pro Tyr His Phe Lys Ala Glu His Arg Ala 
            100                 105                 110         


Pro Phe Pro Ala Gly Arg Phe Gly Phe Leu Ser His Pro Val Thr Pro 
        115                 120                 125             


Asp Val Ser Phe Phe Asp Ser Ser Phe Ala Pro Tyr Leu Thr Thr Gln 
    130                 135                 140                 


His Leu Val Ala Phe Thr Thr Phe Pro Pro Asn Pro Leu Val Trp His 
145                 150                 155                 160 


Leu Glu Arg Ala Glu Thr Ala Ala Thr Ala Glu Arg Pro Phe Gly Val 
                165                 170                 175     


Ser Leu Leu Pro Ala Arg Pro Thr Val Pro Lys Asn Thr Ile Leu Glu 
            180                 185                 190         


His Lys Ala His Phe Ala Thr Trp Asp Ala Leu Ala Arg His Thr Phe 
        195                 200                 205             


Phe Ser Ala Glu Ala Ile Ile Thr Asn Ser Thr Leu Arg Ile His Val 
    210                 215                 220                 


Pro Leu Phe Gly Ser Val Trp Pro Ile Arg Tyr Trp Ala Thr Gly Ser 
225                 230                 235                 240 


Val Leu Leu Thr Ser Asp Ser Gly Arg Val Glu Val Asn Ile Gly Val 
                245                 250                 255     


Gly Phe Met Ser Ser Leu Ile Ser Leu Ser Ser Gly Pro Pro Ile Glu 
            260                 265                 270         


Leu Ile Val Val Pro His Thr Val Lys Leu Asn Ala Val Thr Ser Asp 
        275                 280                 285             


Thr Thr Trp Phe Gln Leu Asn Pro Pro Gly Pro Asp Pro Gly Pro Ser 
    290                 295                 300                 


Tyr Arg Val Tyr Leu Leu Gly Arg Gly Leu Asp Met Asn Phe Ser Lys 
305                 310                 315                 320 


His Ala Thr Val Asp Ile Cys Ala Tyr Pro Glu Glu Ser Leu Asp Tyr 
                325                 330                 335     


Arg Tyr His Leu Ser Met Ala His Thr Glu Ala Leu Arg Met Thr Thr 
            340                 345                 350         


Lys Ala Asp Gln His Asp Ile Asn Glu Glu Ser Tyr Tyr His Ile Ala 
        355                 360                 365             


Ala Arg Ile Ala Thr Ser Ile Phe Ala Leu Ser Glu Met Gly Arg Thr 
    370                 375                 380                 


Thr Glu Tyr Phe Leu Leu Asp Glu Ile Val Asp Val Gln Tyr Gln Leu 
385                 390                 395                 400 


Lys Phe Leu Asn Tyr Ile Leu Met Arg Ile Gly Ala Gly Ala His Pro 
                405                 410                 415     


Asn Thr Ile Ser Gly Thr Ser Asp Leu Ile Phe Ala Asp Pro Ser Gln 
            420                 425                 430         


Leu His Asp Glu Leu Ser Leu Leu Phe Gly Gln Val Lys Pro Ala Asn 
        435                 440                 445             


Val Asp Tyr Phe Ile Ser Tyr Asp Glu Ala Arg Asp Gln Leu Lys Thr 
    450                 455                 460                 


Ala Tyr Ala Leu Ser Arg Gly Gln Asp His Val Asn Ala Leu Ser Leu 
465                 470                 475                 480 


Ala Arg Arg Val Ile Met Ser Ile Tyr Lys Gly Leu Leu Val Lys Gln 
                485                 490                 495     


Asn Leu Asn Ala Thr Glu Arg Gln Ala Leu Phe Phe Ala Ser Met Ile 
            500                 505                 510         


Leu Leu Asn Phe Arg Glu Gly Leu Glu Asn Ser Ser Arg Val Leu Asp 
        515                 520                 525             


Gly Arg Thr Thr Leu Leu Leu Met Thr Ser Met Cys Thr Ala Ala His 
    530                 535                 540                 


Ala Thr Gln Ala Ala Leu Asn Ile Gln Glu Gly Leu Ala Tyr Leu Asn 
545                 550                 555                 560 


Pro Ser Lys His Met Phe Thr Ile Pro Asn Val Tyr Ser Pro Cys Met 
                565                 570                 575     


Gly Ser Leu Arg Thr Asp Leu Thr Glu Glu Ile His Val Met Asn Leu 
            580                 585                 590         


Leu Ser Ala Ile Pro Thr Arg Pro Gly Leu Asn Glu Val Leu His Thr 
        595                 600                 605             


Gln Leu Asp Glu Ser Glu Ile Phe Asp Ala Ala Phe Lys Thr Met Met 
    610                 615                 620                 


Ile Phe Thr Thr Trp Thr Ala Lys Asp Leu His Ile Leu His Thr His 
625                 630                 635                 640 


Val Pro Glu Val Phe Thr Cys Gln Asp Ala Ala Ala Arg Asn Gly Glu 
                645                 650                 655     


Tyr Val Leu Ile Leu Pro Ala Val Gln Gly His Ser Tyr Val Ile Thr 
            660                 665                 670         


Arg Asn Lys Pro Gln Arg Gly Leu Val Tyr Ser Leu Ala Asp Val Asp 
        675                 680                 685             


Val Tyr Asn Pro Ile Ser Val Val Tyr Leu Ser Arg Asp Thr Cys Val 
    690                 695                 700                 


Ser Glu His Gly Val Ile Glu Thr Val Ala Leu Pro His Pro Asp Asn 
705                 710                 715                 720 


Leu Lys Glu Cys Leu Tyr Cys Gly Ser Val Phe Leu Arg Tyr Leu Thr 
                725                 730                 735     


Thr Gly Ala Ile Met Asp Ile Ile Ile Ile Asp Ser Lys Asp Thr Glu 
            740                 745                 750         


Arg Gln Leu Ala Ala Met Gly Asn Ser Thr Ile Pro Pro Phe Asn Pro 
        755                 760                 765             


Asp Met His Gly Asp Asp Ser Lys Ala Val Leu Leu Phe Pro Asn Gly 
    770                 775                 780                 


Thr Val Val Thr Leu Leu Gly Phe Glu Arg Arg Gln Ala Ile Arg Met 
785                 790                 795                 800 


Ser Gly Gln Tyr Leu Gly Ala Ser Leu Gly Gly Ala Phe Leu Ala Val 
                805                 810                 815     


Val Gly Phe Gly Ile Ile Gly Trp Met Leu Cys Gly Asn Ser Arg Leu 
            820                 825                 830         


Arg Glu Tyr Asn Lys Ile Pro Leu Thr 
        835                 840     


<210>  9
<211>  354
<212>  PRT
<213>  Varicella Zoster Virus

<400>  9

Met Phe Leu Ile Gln Cys Leu Ile Ser Ala Val Ile Phe Tyr Ile Gln 
1               5                   10                  15      


Val Thr Asn Ala Leu Ile Phe Lys Gly Asp His Val Ser Leu Gln Val 
            20                  25                  30          


Asn Ser Ser Leu Thr Ser Ile Leu Ile Pro Met Gln Asn Asp Asn Tyr 
        35                  40                  45              


Thr Glu Ile Lys Gly Gln Leu Val Phe Ile Gly Glu Gln Leu Pro Thr 
    50                  55                  60                  


Gly Thr Asn Tyr Ser Gly Thr Leu Glu Leu Leu Tyr Ala Asp Thr Val 
65                  70                  75                  80  


Ala Phe Cys Phe Arg Ser Val Gln Val Ile Arg Tyr Asp Gly Cys Pro 
                85                  90                  95      


Arg Ile Arg Thr Ser Ala Phe Ile Ser Cys Arg Tyr Lys His Ser Trp 
            100                 105                 110         


His Tyr Gly Asn Ser Thr Asp Arg Ile Ser Thr Glu Pro Asp Ala Gly 
        115                 120                 125             


Val Met Leu Lys Ile Thr Lys Pro Gly Ile Asn Asp Ala Gly Val Tyr 
    130                 135                 140                 


Val Leu Leu Val Arg Leu Asp His Ser Arg Ser Thr Asp Gly Phe Ile 
145                 150                 155                 160 


Leu Gly Val Asn Val Tyr Thr Ala Gly Ser His His Asn Ile His Gly 
                165                 170                 175     


Val Ile Tyr Thr Ser Pro Ser Leu Gln Asn Gly Tyr Ser Thr Arg Ala 
            180                 185                 190         


Leu Phe Gln Gln Ala Arg Leu Cys Asp Leu Pro Ala Thr Pro Lys Gly 
        195                 200                 205             


Ser Gly Thr Ser Leu Phe Gln His Met Leu Asp Leu Arg Ala Gly Lys 
    210                 215                 220                 


Ser Leu Glu Asp Asn Pro Trp Leu His Glu Asp Val Val Thr Thr Glu 
225                 230                 235                 240 


Thr Lys Ser Val Val Lys Glu Gly Ile Glu Asn His Val Tyr Pro Thr 
                245                 250                 255     


Asp Met Ser Thr Leu Pro Glu Lys Ser Leu Asn Asp Pro Pro Glu Asn 
            260                 265                 270         


Leu Leu Ile Ile Ile Pro Ile Val Ala Ser Val Met Ile Leu Thr Ala 
        275                 280                 285             


Met Val Ile Val Ile Val Ile Ser Val Lys Arg Arg Arg Ile Lys Lys 
    290                 295                 300                 


His Pro Ile Tyr Arg Pro Asn Thr Lys Thr Arg Arg Gly Ile Gln Asn 
305                 310                 315                 320 


Ala Thr Pro Glu Ser Asp Val Met Leu Glu Ala Ala Ile Ala Gln Leu 
                325                 330                 335     


Ala Thr Ile Arg Glu Glu Ser Pro Pro His Ser Val Val Asn Pro Phe 
            340                 345                 350         


Val Lys 
        


<210>  10
<211>  868
<212>  PRT
<213>  Varicella Zoster Virus

<400>  10

Met Phe Val Thr Ala Val Val Ser Val Ser Pro Ser Ser Phe Tyr Glu 
1               5                   10                  15      


Ser Leu Gln Val Glu Pro Thr Gln Ser Glu Asp Ile Thr Arg Ser Ala 
            20                  25                  30          


His Leu Gly Asp Gly Asp Glu Ile Arg Glu Ala Ile His Lys Ser Gln 
        35                  40                  45              


Asp Ala Glu Thr Lys Pro Thr Phe Tyr Val Cys Pro Pro Pro Thr Gly 
    50                  55                  60                  


Ser Thr Ile Val Arg Leu Glu Pro Thr Arg Thr Cys Pro Asp Tyr His 
65                  70                  75                  80  


Leu Gly Lys Asn Phe Thr Glu Gly Ile Ala Val Val Tyr Lys Glu Asn 
                85                  90                  95      


Ile Ala Ala Tyr Lys Phe Lys Ala Thr Val Tyr Tyr Lys Asp Val Ile 
            100                 105                 110         


Val Ser Thr Ala Trp Ala Gly Ser Ser Tyr Thr Gln Ile Thr Asn Arg 
        115                 120                 125             


Tyr Ala Asp Arg Val Pro Ile Pro Val Ser Glu Ile Thr Asp Thr Ile 
    130                 135                 140                 


Asp Lys Phe Gly Lys Cys Ser Ser Lys Ala Thr Tyr Val Arg Asn Asn 
145                 150                 155                 160 


His Lys Val Glu Ala Phe Asn Glu Asp Lys Asn Pro Gln Asp Met Pro 
                165                 170                 175     


Leu Ile Ala Ser Lys Tyr Asn Ser Val Gly Ser Lys Ala Trp His Thr 
            180                 185                 190         


Thr Asn Asp Thr Tyr Met Val Ala Gly Thr Pro Gly Thr Tyr Arg Thr 
        195                 200                 205             


Gly Thr Ser Val Asn Cys Ile Ile Glu Glu Val Glu Ala Arg Ser Ile 
    210                 215                 220                 


Phe Pro Tyr Asp Ser Phe Gly Leu Ser Thr Gly Asp Ile Ile Tyr Met 
225                 230                 235                 240 


Ser Pro Phe Phe Gly Leu Arg Asp Gly Ala Tyr Arg Glu His Ser Asn 
                245                 250                 255     


Tyr Ala Met Asp Arg Phe His Gln Phe Glu Gly Tyr Arg Gln Arg Asp 
            260                 265                 270         


Leu Asp Thr Arg Ala Leu Leu Glu Pro Ala Ala Arg Asn Phe Leu Val 
        275                 280                 285             


Thr Pro His Leu Thr Val Gly Trp Asn Trp Lys Pro Lys Arg Thr Glu 
    290                 295                 300                 


Val Cys Ser Leu Val Lys Trp Arg Glu Val Glu Asp Val Val Arg Asp 
305                 310                 315                 320 


Glu Tyr Ala His Asn Phe Arg Phe Thr Met Lys Thr Leu Ser Thr Thr 
                325                 330                 335     


Phe Ile Ser Glu Thr Asn Glu Phe Asn Leu Asn Gln Ile His Leu Ser 
            340                 345                 350         


Gln Cys Val Lys Glu Glu Ala Arg Ala Ile Ile Asn Arg Ile Tyr Thr 
        355                 360                 365             


Thr Arg Tyr Asn Ser Ser His Val Arg Thr Gly Asp Ile Gln Thr Tyr 
    370                 375                 380                 


Leu Ala Arg Gly Gly Phe Val Val Val Phe Gln Pro Leu Leu Ser Asn 
385                 390                 395                 400 


Ser Leu Ala Arg Leu Tyr Leu Gln Glu Leu Val Arg Glu Asn Thr Asn 
                405                 410                 415     


His Ser Pro Gln Lys His Pro Thr Arg Asn Thr Arg Ser Arg Arg Ser 
            420                 425                 430         


Val Pro Val Glu Leu Arg Ala Asn Arg Thr Ile Thr Thr Thr Ser Ser 
        435                 440                 445             


Val Glu Phe Ala Met Leu Gln Phe Thr Tyr Asp His Ile Gln Glu His 
    450                 455                 460                 


Val Asn Glu Met Leu Ala Arg Ile Ser Ser Ser Trp Cys Gln Leu Gln 
465                 470                 475                 480 


Asn Arg Glu Arg Ala Leu Trp Ser Gly Leu Phe Pro Ile Asn Pro Ser 
                485                 490                 495     


Ala Leu Ala Ser Thr Ile Leu Asp Gln Arg Val Lys Ala Arg Ile Leu 
            500                 505                 510         


Gly Asp Val Ile Ser Val Ser Asn Cys Pro Glu Leu Gly Ser Asp Thr 
        515                 520                 525             


Arg Ile Ile Leu Gln Asn Ser Met Arg Val Ser Gly Ser Thr Thr Arg 
    530                 535                 540                 


Cys Tyr Ser Arg Pro Leu Ile Ser Ile Val Ser Leu Asn Gly Ser Gly 
545                 550                 555                 560 


Thr Val Glu Gly Gln Leu Gly Thr Asp Asn Glu Leu Ile Met Ser Arg 
                565                 570                 575     


Asp Leu Leu Glu Pro Cys Val Ala Asn His Lys Arg Tyr Phe Leu Phe 
            580                 585                 590         


Gly His His Tyr Val Tyr Tyr Glu Asp Tyr Arg Tyr Val Arg Glu Ile 
        595                 600                 605             


Ala Val His Asp Val Gly Met Ile Ser Thr Tyr Val Asp Leu Asn Leu 
    610                 615                 620                 


Thr Leu Leu Lys Asp Arg Glu Phe Met Pro Leu Gln Val Tyr Thr Arg 
625                 630                 635                 640 


Asp Glu Leu Arg Asp Thr Gly Leu Leu Asp Tyr Ser Glu Ile Gln Arg 
                645                 650                 655     


Arg Asn Gln Met His Ser Leu Arg Phe Tyr Asp Ile Asp Lys Val Val 
            660                 665                 670         


Gln Tyr Asp Ser Gly Thr Ala Ile Met Gln Gly Met Ala Gln Phe Phe 
        675                 680                 685             


Gln Gly Leu Gly Thr Ala Gly Gln Ala Val Gly His Val Val Leu Gly 
    690                 695                 700                 


Ala Thr Gly Ala Leu Leu Ser Thr Val His Gly Phe Thr Thr Phe Leu 
705                 710                 715                 720 


Ser Asn Pro Phe Gly Ala Leu Ala Val Gly Leu Leu Val Leu Ala Gly 
                725                 730                 735     


Leu Val Ala Ala Phe Phe Ala Tyr Arg Tyr Val Leu Lys Leu Lys Thr 
            740                 745                 750         


Ser Pro Met Lys Ala Leu Tyr Pro Leu Thr Thr Lys Gly Leu Lys Gln 
        755                 760                 765             


Leu Pro Glu Gly Met Asp Pro Phe Ala Glu Lys Pro Asn Ala Thr Asp 
    770                 775                 780                 


Thr Pro Ile Glu Glu Ile Gly Asp Ser Gln Asn Thr Glu Pro Ser Val 
785                 790                 795                 800 


Asn Ser Gly Phe Asp Pro Asp Lys Phe Arg Glu Ala Gln Glu Met Ile 
                805                 810                 815     


Lys Tyr Met Thr Leu Val Ser Ala Ala Glu Arg Gln Glu Ser Lys Ala 
            820                 825                 830         


Arg Lys Lys Asn Lys Thr Ser Ala Leu Leu Thr Ser Arg Leu Thr Gly 
        835                 840                 845             


Leu Ala Leu Arg Asn Arg Arg Gly Tyr Ser Arg Val Arg Thr Glu Asn 
    850                 855                 860                 


Val Thr Gly Val 
865             


<210>  11
<211>  1872
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VZV Orf68 gE for expression in insect cells

<400>  11
atgggcaccg tgaacaagcc cgtggtgggc gtgctgatgg gtttcggtat catcaccggc       60

accctgcgta tcaccaaccc cgtgcgtgct tccgtgctgc gttacgacga cttccacacc      120

gacgaggaca agctggacac caactccgtg tacgagccct actaccactc cgaccacgct      180

gagtcctctt gggtgaaccg tggcgagtcc tcccgtaagg cttacgacca caactccccc      240

tacatctggc cccgtaacga ctacgacggt ttcctcgaga acgctcacga gcaccacggt      300

gtctacaacc agggtcgtgg tatcgactcc ggcgagcgtc tgatgcagcc cacccagatg      360

tccgctcagg aggacctggg cgacgacacc ggtatccacg tgatccccac cctgaacggt      420

gacgaccgtc acaagatcgt gaacgtggac cagcgccagt acggtgacgt gttcaagggt      480

gacctgaacc ccaagcccca gggccagcgt ctgatcgagg tgtccgtgga ggagaaccac      540

cccttcaccc tgcgtgctcc catccagcgt atctacggtg tccgttacac cgagacctgg      600

tccttcctcc cctccctgac ctgcaccggt gacgctgctc ccgctatcca gcacatctgc      660

ctgaagcaca ccacctgctt ccaggacgtg gtggtggacg tggactgcgc tgagaacacc      720

aaggaggacc agctggctga gatctcctac aggttccagg gcaagaagga ggctgaccag      780

ccctggatcg tggtgaacac ctccaccctg ttcgacgagc tggagctgga cccccccgag      840

atcgagcccg gtgtcctgaa ggtgctgcgt accgagaagc agtacctggg cgtgtacatc      900

tggaacatgc gtggttccga cggcacctcc acctacgcta ccttcctcgt gacctggaag      960

ggtgacgaaa agacccgtaa ccccaccccc gctgtgaccc cccagccccg tggtgctgaa     1020

ttccatatgt ggaactacca ctctcacgtg ttctccgtgg gtgacacctt ctccctggct     1080

atgcacctgc agtacaagat ccacgaggct cccttcgacc tgctgctcga gtggctgtac     1140

gtgcccatcg accccacctg ccagcccatg cgcctgtact ccacctgcct gtaccacccc     1200

aacgctcccc agtgcctgtc ccacatgaac tccggttgca ccttcacctc cccccacctg     1260

gcccagcgtg tggcttccac cgtgtaccag aactgcgagc acgctgacaa ctacaccgct     1320

tactgcctgg gtatcagcca catggagcct tccttcggtc tgatcctgca cgacggtggc     1380

accaccctga agttcgtgga cacccccgag tccctgtccg gtctgtacgt gttcgtggtg     1440

tacttcaacg gtcacgtgga ggctgtcgct tacaccgtgg tgtccaccgt ggaccacttc     1500

gtgaacgcta tcgaggagcg tggtttcccc cccaccgctg gccagccccc tgctaccacc     1560

aagcccaagg agatcacccc cgtcaacccc ggcacctccc ctctgctgcg ctacgctgct     1620

tggaccggtg gtctggctgc tgtggtgctg ctgtgcctgg tgatcttcct gatctgcacc     1680

gctaagagga tgcgtgtgaa ggcttaccgt gtggacaagt ccccttacaa ccagtccatg     1740

tactacgctg gtctgcccgt cgacgacttc gaggactccg agtccaccga caccgaggag     1800

gagttcggta acgctatcgg tggttcccac ggtggttcct cctacaccgt gtacatcgac     1860

aagacccgct aa                                                         1872


<210>  12
<211>  1728
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VZV Orf68TCM for expression in insect cells

<400>  12
atgggcaccg tgaacaagcc cgtggtgggc gtgctgatgg gtttcggtat catcaccggc       60

accctgcgta tcaccaaccc cgtgcgtgct tccgtgctgc gttacgacga cttccacacc      120

gacgaggaca agctggacac caactccgtg tacgagccct actaccactc cgaccacgct      180

gagtcctctt gggtgaaccg tggcgagtcc tcccgtaagg cttacgacca caactccccc      240

tacatctggc cccgtaacga ctacgacggt ttcctcgaga acgctcacga gcaccacggt      300

gtctacaacc agggtcgtgg tatcgactcc ggcgagcgtc tgatgcagcc cacccagatg      360

tccgctcagg aggacctggg cgacgacacc ggtatccacg tgatccccac cctgaacggt      420

gacgaccgtc acaagatcgt gaacgtggac cagcgccagt acggtgacgt gttcaagggt      480

gacctgaacc ccaagcccca gggccagcgt ctgatcgagg tgtccgtgga ggagaaccac      540

cccttcaccc tgcgtgctcc catccagcgt atctacggtg tccgttacac cgagacctgg      600

tccttcctcc cctccctgac ctgcaccggt gacgctgctc ccgctatcca gcacatctgc      660

ctgaagcaca ccacctgctt ccaggacgtg gtggtggacg tggactgcgc tgagaacacc      720

aaggaggacc agctggctga gatctcctac aggttccagg gcaagaagga ggctgaccag      780

ccctggatcg tggtgaacac ctccaccctg ttcgacgagc tggagctgga cccccccgag      840

atcgagcccg gtgtcctgaa ggtgctgcgt accgagaagc agtacctggg cgtgtacatc      900

tggaacatgc gtggttccga cggcacctcc acctacgcta ccttcctcgt gacctggaag      960

ggtgacgaaa agacccgtaa ccccaccccc gctgtgaccc cccagccccg tggtgctgaa     1020

ttccatatgt ggaactacca ctctcacgtg ttctccgtgg gtgacacctt ctccctggct     1080

atgcacctgc agtacaagat ccacgaggct cccttcgacc tgctgctcga gtggctgtac     1140

gtgcccatcg accccacctg ccagcccatg cgcctgtact ccacctgcct gtaccacccc     1200

aacgctcccc agtgcctgtc ccacatgaac tccggttgca ccttcacctc cccccacctg     1260

gcccagcgtg tggcttccac cgtgtaccag aactgcgagc acgctgacaa ctacaccgct     1320

tactgcctgg gtatcagcca catggagcct tccttcggtc tgatcctgca cgacggtggc     1380

accaccctga agttcgtgga cacccccgag tccctgtccg gtctgtacgt gttcgtggtg     1440

tacttcaacg gtcacgtgga ggctgtcgct tacaccgtgg tgtccaccgt ggaccacttc     1500

gtgaacgcta tcgaggagcg tggtttcccc cccaccgctg gccagccccc tgctaccacc     1560

aagcccaagg agatcacccc cgtcaacccc ggcacctccc ctctgctgcg cgactggatc     1620

ttgtggatct ccttcgctat ctcctgcttc ctgctgtgcg tggctctgct gggtttcatc     1680

atgtgggctt gccagaaggg taacatccgt tgcaacatct gcatctaa                  1728


<210>  13
<211>  1310
<212>  PRT
<213>  Varicella Zoster Virus

<400>  13

Met Asp Thr Pro Pro Met Gln Arg Ser Thr Pro Gln Arg Ala Gly Ser 
1               5                   10                  15      


Pro Asp Thr Leu Glu Leu Met Asp Leu Leu Asp Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Glu His Arg Ala Arg Val Val Thr Ser Ser Gln Pro Asp Asp Leu 
        35                  40                  45              


Leu Phe Gly Glu Asn Gly Val Met Val Gly Arg Glu His Glu Ile Val 
    50                  55                  60                  


Ser Ile Pro Ser Val Ser Gly Leu Gln Pro Glu Pro Arg Thr Glu Asp 
65                  70                  75                  80  


Val Gly Glu Glu Leu Thr Gln Asp Asp Tyr Val Cys Glu Asp Gly Gln 
                85                  90                  95      


Asp Leu Met Gly Ser Pro Val Ile Pro Leu Ala Glu Val Phe His Thr 
            100                 105                 110         


Arg Phe Ser Glu Ala Gly Ala Arg Glu Pro Thr Gly Ala Asp Arg Ser 
        115                 120                 125             


Leu Glu Thr Val Ser Leu Gly Thr Lys Leu Ala Arg Ser Pro Lys Pro 
    130                 135                 140                 


Pro Met Asn Asp Gly Glu Thr Gly Arg Gly Thr Thr Pro Pro Phe Pro 
145                 150                 155                 160 


Gln Ala Phe Ser Pro Val Ser Pro Ala Ser Pro Val Gly Asp Ala Ala 
                165                 170                 175     


Gly Asn Asp Gln Arg Glu Asp Gln Arg Ser Ile Pro Arg Gln Thr Thr 
            180                 185                 190         


Arg Gly Asn Ser Pro Gly Leu Pro Ser Val Val His Arg Asp Arg Gln 
        195                 200                 205             


Thr Gln Ser Ile Ser Gly Lys Lys Pro Gly Asp Glu Gln Ala Gly His 
    210                 215                 220                 


Ala His Ala Ser Gly Asp Gly Val Val Leu Gln Lys Thr Gln Arg Pro 
225                 230                 235                 240 


Ala Gln Gly Lys Ser Pro Lys Lys Lys Thr Leu Lys Val Lys Val Pro 
                245                 250                 255     


Leu Pro Ala Arg Lys Pro Gly Gly Pro Val Pro Gly Pro Val Glu Gln 
            260                 265                 270         


Leu Tyr His Val Leu Ser Asp Ser Val Pro Ala Lys Gly Ala Lys Ala 
        275                 280                 285             


Asp Leu Pro Phe Glu Thr Asp Asp Thr Arg Pro Arg Lys His Asp Ala 
    290                 295                 300                 


Arg Gly Ile Thr Pro Arg Val Pro Gly Arg Ser Ser Gly Gly Lys Pro 
305                 310                 315                 320 


Arg Ala Phe Leu Ala Leu Pro Gly Arg Ser His Ala Pro Asp Pro Ile 
                325                 330                 335     


Glu Asp Asp Ser Pro Val Glu Lys Lys Pro Lys Ser Arg Glu Phe Val 
            340                 345                 350         


Ser Ser Ser Ser Ser Ser Ser Ser Trp Gly Ser Ser Ser Glu Asp Glu 
        355                 360                 365             


Asp Asp Glu Pro Arg Arg Val Ser Val Gly Ser Glu Thr Thr Gly Ser 
    370                 375                 380                 


Arg Ser Gly Arg Glu His Ala Pro Ser Pro Ser Asn Ser Asp Asp Ser 
385                 390                 395                 400 


Asp Ser Asn Asp Gly Gly Ser Thr Lys Gln Asn Ile Gln Pro Gly Tyr 
                405                 410                 415     


Arg Ser Ile Ser Gly Pro Asp Pro Arg Ile Arg Lys Thr Lys Arg Leu 
            420                 425                 430         


Ala Gly Glu Pro Gly Arg Gln Arg Gln Lys Ser Phe Ser Leu Pro Arg 
        435                 440                 445             


Ser Arg Thr Pro Ile Ile Pro Pro Val Ser Gly Pro Leu Met Met Pro 
    450                 455                 460                 


Asp Gly Ser Pro Trp Pro Gly Ser Ala Pro Leu Pro Ser Asn Arg Val 
465                 470                 475                 480 


Arg Phe Gly Pro Ser Gly Glu Thr Arg Glu Gly His Trp Glu Asp Glu 
                485                 490                 495     


Ala Val Arg Ala Ala Arg Ala Arg Tyr Glu Ala Ser Thr Glu Pro Val 
            500                 505                 510         


Pro Leu Tyr Val Pro Glu Leu Gly Asp Pro Ala Arg Gln Tyr Arg Ala 
        515                 520                 525             


Leu Ile Asn Leu Ile Tyr Cys Pro Asp Arg Asp Pro Ile Ala Trp Leu 
    530                 535                 540                 


Gln Asn Pro Lys Leu Thr Gly Val Asn Ser Ala Leu Asn Gln Phe Tyr 
545                 550                 555                 560 


Gln Lys Leu Leu Pro Pro Gly Arg Ala Gly Thr Ala Val Thr Gly Ser 
                565                 570                 575     


Val Ala Ser Pro Val Pro His Val Gly Glu Ala Met Ala Thr Gly Glu 
            580                 585                 590         


Ala Leu Trp Ala Leu Pro His Ala Ala Ala Ala Val Ala Met Ser Arg 
        595                 600                 605             


Arg Tyr Asp Arg Ala Gln Lys His Phe Ile Leu Gln Ser Leu Arg Arg 
    610                 615                 620                 


Ala Phe Ala Ser Met Ala Tyr Pro Glu Ala Thr Gly Ser Ser Pro Ala 
625                 630                 635                 640 


Ala Arg Ile Ser Arg Gly His Pro Ser Pro Thr Thr Pro Ala Thr Gln 
                645                 650                 655     


Thr Pro Asp Pro Gln Pro Ser Ala Ala Ala Arg Ser Leu Ser Val Cys 
            660                 665                 670         


Pro Pro Asp Asp Arg Leu Arg Thr Pro Arg Lys Arg Lys Ser Gln Pro 
        675                 680                 685             


Val Glu Ser Arg Ser Leu Leu Asp Lys Ile Arg Glu Thr Pro Val Ala 
    690                 695                 700                 


Asp Ala Arg Val Ala Asp Asp His Val Val Ser Lys Ala Lys Arg Arg 
705                 710                 715                 720 


Val Ser Glu Pro Val Thr Ile Thr Ser Gly Pro Val Val Asp Pro Pro 
                725                 730                 735     


Ala Val Ile Thr Met Pro Leu Asp Gly Pro Ala Pro Asn Gly Gly Phe 
            740                 745                 750         


Arg Arg Ile Pro Arg Gly Ala Leu His Thr Pro Val Pro Ser Asp Gln 
        755                 760                 765             


Ala Arg Lys Ala Tyr Cys Thr Pro Glu Thr Ile Ala Arg Leu Val Asp 
    770                 775                 780                 


Asp Pro Leu Phe Pro Thr Ala Trp Arg Pro Ala Leu Ser Phe Asp Pro 
785                 790                 795                 800 


Gly Ala Leu Ala Glu Ile Ala Ala Arg Arg Pro Gly Gly Gly Asp Arg 
                805                 810                 815     


Arg Phe Gly Pro Pro Ser Gly Val Glu Ala Leu Arg Arg Arg Cys Ala 
            820                 825                 830         


Trp Met Arg Gln Ile Pro Asp Pro Glu Asp Val Arg Leu Leu Ile Ile 
        835                 840                 845             


Tyr Asp Pro Leu Pro Gly Glu Asp Ile Asn Gly Pro Leu Glu Ser Thr 
    850                 855                 860                 


Leu Ala Thr Asp Pro Gly Pro Ser Trp Ser Pro Ser Arg Gly Gly Leu 
865                 870                 875                 880 


Ser Val Val Leu Ala Ala Leu Ser Asn Arg Leu Cys Leu Pro Ser Thr 
                885                 890                 895     


His Ala Trp Ala Gly Asn Trp Thr Gly Pro Pro Asp Val Ser Ala Leu 
            900                 905                 910         


Asn Ala Arg Gly Val Leu Leu Leu Ser Thr Arg Asp Leu Ala Phe Ala 
        915                 920                 925             


Gly Ala Val Glu Tyr Leu Gly Ser Arg Leu Ala Ser Ala Arg Arg Arg 
    930                 935                 940                 


Leu Leu Val Leu Asp Ala Val Ala Leu Glu Arg Trp Pro Arg Asp Gly 
945                 950                 955                 960 


Pro Ala Leu Ser Gln Tyr His Val Tyr Val Arg Ala Pro Ala Arg Pro 
                965                 970                 975     


Asp Ala Gln Ala Val Val Arg Trp Pro Asp Ser Ala Val Thr Glu Gly 
            980                 985                 990         


Leu Ala Arg Ala Val Phe Ala Ser  Ser Arg Thr Phe Gly  Pro Ala Ser 
        995                 1000                 1005             


Phe Ala  Arg Ile Glu Thr Ala  Phe Ala Asn Leu Tyr  Pro Gly Glu 
    1010                 1015                 1020             


Gln Pro  Leu Cys Leu Cys Arg  Gly Gly Asn Val Ala  Tyr Thr Val 
    1025                 1030                 1035             


Cys Thr  Arg Ala Gly Pro Lys  Thr Arg Val Pro Leu  Ser Pro Arg 
    1040                 1045                 1050             


Glu Tyr  Arg Gln Tyr Val Leu  Pro Gly Phe Asp Gly  Cys Lys Asp 
    1055                 1060                 1065             


Leu Ala  Arg Gln Ser Arg Gly  Leu Gly Leu Gly Ala  Ala Asp Phe 
    1070                 1075                 1080             


Val Asp  Glu Ala Ala His Ser  His Arg Ala Ala Asn  Arg Trp Gly 
    1085                 1090                 1095             


Leu Gly  Ala Ala Leu Arg Pro  Val Phe Leu Pro Glu  Gly Arg Arg 
    1100                 1105                 1110             


Pro Gly  Ala Ala Gly Pro Glu  Ala Gly Asp Val Pro  Thr Trp Ala 
    1115                 1120                 1125             


Arg Val  Phe Cys Arg His Ala  Leu Leu Glu Pro Asp  Pro Ala Ala 
    1130                 1135                 1140             


Glu Pro  Leu Val Leu Pro Pro  Val Ala Gly Arg Ser  Val Ala Leu 
    1145                 1150                 1155             


Tyr Ala  Ser Ala Asp Glu Ala  Arg Asn Ala Leu Pro  Pro Ile Pro 
    1160                 1165                 1170             


Arg Val  Met Trp Pro Pro Gly  Phe Gly Ala Ala Glu  Thr Val Leu 
    1175                 1180                 1185             


Glu Gly  Ser Asp Gly Thr Arg  Phe Val Phe Gly His  His Gly Gly 
    1190                 1195                 1200             


Ser Glu  Arg Pro Ala Glu Thr  Gln Ala Gly Arg Gln  Arg Arg Thr 
    1205                 1210                 1215             


Ala Asp  Asp Arg Glu His Ala  Leu Glu Pro Asp Asp  Trp Glu Val 
    1220                 1225                 1230             


Gly Cys  Glu Asp Ala Trp Asp  Ser Glu Glu Gly Gly  Gly Asp Asp 
    1235                 1240                 1245             


Gly Asp  Ala Pro Gly Ser Ser  Phe Gly Val Ser Ile  Val Ser Val 
    1250                 1255                 1260             


Ala Pro  Gly Val Leu Arg Asp  Arg Arg Val Gly Leu  Arg Pro Ala 
    1265                 1270                 1275             


Val Lys  Val Glu Leu Leu Ser  Ser Ser Ser Ser Ser  Glu Asp Glu 
    1280                 1285                 1290             


Asp Asp  Val Trp Gly Gly Arg  Gly Gly Arg Ser Pro  Pro Gln Ser 
    1295                 1300                 1305             


Arg Gly  
    1310 


<210>  14
<211>  1310
<212>  PRT
<213>  Varicella Zoster Virus


<220>
<221>  misc_feature
<222>  (657)..(657)
<223>  Xaa may be Thr or Ala

<220>
<221>  misc_feature
<222>  (1208)..(1208)
<223>  Xaa may be Ala or Ser

<220>
<221>  misc_feature
<222>  (1228)..(1228)
<223>  Xaa may be Pro or Leu

<400>  14

Met Asp Thr Pro Pro Met Gln Arg Ser Thr Pro Gln Arg Ala Gly Ser 
1               5                   10                  15      


Pro Asp Thr Leu Glu Leu Met Asp Leu Leu Asp Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Glu His Arg Ala Arg Val Val Thr Ser Ser Gln Pro Asp Asp Leu 
        35                  40                  45              


Leu Phe Gly Glu Asn Gly Val Met Val Gly Arg Glu His Glu Ile Val 
    50                  55                  60                  


Ser Ile Pro Ser Val Ser Gly Leu Gln Pro Glu Pro Arg Thr Glu Asp 
65                  70                  75                  80  


Val Gly Glu Glu Leu Thr Gln Asp Asp Tyr Val Cys Glu Asp Gly Gln 
                85                  90                  95      


Asp Leu Met Gly Ser Pro Val Ile Pro Leu Ala Glu Val Phe His Thr 
            100                 105                 110         


Arg Phe Ser Glu Ala Gly Ala Arg Glu Pro Thr Gly Ala Asp Arg Ser 
        115                 120                 125             


Leu Glu Thr Val Ser Leu Gly Thr Lys Leu Ala Arg Ser Pro Lys Pro 
    130                 135                 140                 


Pro Met Asn Asp Gly Glu Thr Gly Arg Gly Thr Thr Pro Pro Phe Pro 
145                 150                 155                 160 


Gln Ala Phe Ser Pro Val Ser Pro Ala Ser Pro Val Gly Asp Ala Ala 
                165                 170                 175     


Gly Asn Asp Gln Arg Glu Asp Gln Arg Ser Ile Pro Arg Gln Thr Thr 
            180                 185                 190         


Arg Gly Asn Ser Pro Gly Leu Pro Ser Val Val His Arg Asp Arg Gln 
        195                 200                 205             


Thr Gln Ser Ile Ser Gly Lys Lys Pro Gly Asp Glu Gln Ala Gly His 
    210                 215                 220                 


Ala His Ala Ser Gly Asp Gly Val Val Leu Gln Lys Thr Gln Arg Pro 
225                 230                 235                 240 


Ala Gln Gly Lys Ser Pro Lys Lys Lys Thr Leu Lys Val Lys Val Pro 
                245                 250                 255     


Leu Pro Ala Arg Lys Pro Gly Gly Pro Val Pro Gly Pro Val Glu Gln 
            260                 265                 270         


Leu Tyr His Val Leu Ser Asp Ser Val Pro Ala Lys Gly Ala Lys Ala 
        275                 280                 285             


Asp Leu Pro Phe Glu Thr Asp Asp Thr Arg Pro Arg Lys His Asp Ala 
    290                 295                 300                 


Arg Gly Ile Thr Pro Arg Val Pro Gly Arg Ser Ser Gly Gly Lys Pro 
305                 310                 315                 320 


Arg Ala Phe Leu Ala Leu Pro Gly Arg Ser His Ala Pro Asp Pro Ile 
                325                 330                 335     


Glu Asp Asp Ser Pro Val Glu Lys Lys Pro Lys Ser Arg Glu Phe Val 
            340                 345                 350         


Ser Ser Ser Ser Ser Ser Ser Ser Trp Gly Ser Ser Ser Glu Asp Glu 
        355                 360                 365             


Asp Asp Glu Pro Arg Arg Val Ser Val Gly Ser Glu Thr Thr Gly Ser 
    370                 375                 380                 


Arg Ser Gly Arg Glu His Ala Pro Ser Pro Ser Asn Ser Asp Asp Ser 
385                 390                 395                 400 


Asp Ser Asn Asp Gly Gly Ser Thr Lys Gln Asn Ile Gln Pro Gly Tyr 
                405                 410                 415     


Arg Ser Ile Ser Gly Pro Asp Pro Arg Ile Arg Lys Thr Lys Arg Leu 
            420                 425                 430         


Ala Gly Glu Pro Gly Arg Gln Arg Gln Lys Ser Phe Ser Leu Pro Arg 
        435                 440                 445             


Ser Arg Thr Pro Ile Ile Pro Pro Val Ser Gly Pro Leu Met Met Pro 
    450                 455                 460                 


Asp Gly Ser Pro Trp Pro Gly Ser Ala Pro Leu Pro Ser Asn Arg Val 
465                 470                 475                 480 


Arg Phe Gly Pro Ser Gly Glu Thr Arg Glu Gly His Trp Glu Asp Glu 
                485                 490                 495     


Ala Val Arg Ala Ala Arg Ala Arg Tyr Glu Ala Ser Thr Glu Pro Val 
            500                 505                 510         


Pro Leu Tyr Val Pro Glu Leu Gly Asp Pro Ala Arg Gln Tyr Arg Ala 
        515                 520                 525             


Leu Ile Asn Leu Ile Tyr Cys Pro Asp Arg Asp Pro Ile Ala Trp Leu 
    530                 535                 540                 


Gln Asn Pro Lys Leu Thr Gly Val Asn Ser Ala Leu Asn Gln Phe Tyr 
545                 550                 555                 560 


Gln Lys Leu Leu Pro Pro Gly Arg Ala Gly Thr Ala Val Thr Gly Ser 
                565                 570                 575     


Val Ala Ser Pro Val Pro His Val Gly Glu Ala Met Ala Thr Gly Glu 
            580                 585                 590         


Ala Leu Trp Ala Leu Pro His Ala Ala Ala Ala Val Ala Met Ser Arg 
        595                 600                 605             


Arg Tyr Asp Arg Ala Gln Lys His Phe Ile Leu Gln Ser Leu Arg Arg 
    610                 615                 620                 


Ala Phe Ala Ser Met Ala Tyr Pro Glu Ala Thr Gly Ser Ser Pro Ala 
625                 630                 635                 640 


Ala Arg Ile Ser Arg Gly His Pro Ser Pro Thr Thr Pro Ala Thr Gln 
                645                 650                 655     


Xaa Pro Asp Pro Gln Pro Ser Ala Ala Ala Arg Ser Leu Ser Val Cys 
            660                 665                 670         


Pro Pro Asp Asp Arg Leu Arg Thr Pro Arg Lys Arg Lys Ser Gln Pro 
        675                 680                 685             


Val Glu Ser Arg Ser Leu Leu Asp Lys Ile Arg Glu Thr Pro Val Ala 
    690                 695                 700                 


Asp Ala Arg Val Ala Asp Asp His Val Val Ser Lys Ala Lys Arg Arg 
705                 710                 715                 720 


Val Ser Glu Pro Val Thr Ile Thr Ser Gly Pro Val Val Asp Pro Pro 
                725                 730                 735     


Ala Val Ile Thr Met Pro Leu Asp Gly Pro Ala Pro Asn Gly Gly Phe 
            740                 745                 750         


Arg Arg Ile Pro Arg Gly Ala Leu His Thr Pro Val Pro Ser Asp Gln 
        755                 760                 765             


Ala Arg Lys Ala Tyr Cys Thr Pro Glu Thr Ile Ala Arg Leu Val Asp 
    770                 775                 780                 


Asp Pro Leu Phe Pro Thr Ala Trp Arg Pro Ala Leu Ser Phe Asp Pro 
785                 790                 795                 800 


Gly Ala Leu Ala Glu Ile Ala Ala Arg Arg Pro Gly Gly Gly Asp Arg 
                805                 810                 815     


Arg Phe Gly Pro Pro Ser Gly Val Glu Ala Leu Arg Arg Arg Cys Ala 
            820                 825                 830         


Trp Met Arg Gln Ile Pro Asp Pro Glu Asp Val Arg Leu Leu Ile Ile 
        835                 840                 845             


Tyr Asp Pro Leu Pro Gly Glu Asp Ile Asn Gly Pro Leu Glu Ser Thr 
    850                 855                 860                 


Leu Ala Thr Asp Pro Gly Pro Ser Trp Ser Pro Ser Arg Gly Gly Leu 
865                 870                 875                 880 


Ser Val Val Leu Ala Ala Leu Ser Asn Arg Leu Cys Leu Pro Ser Thr 
                885                 890                 895     


His Ala Trp Ala Gly Asn Trp Thr Gly Pro Pro Asp Val Ser Ala Leu 
            900                 905                 910         


Asn Ala Arg Gly Val Leu Leu Leu Ser Thr Arg Asp Leu Ala Phe Ala 
        915                 920                 925             


Gly Ala Val Glu Tyr Leu Gly Ser Arg Leu Ala Ser Ala Arg Arg Arg 
    930                 935                 940                 


Leu Leu Val Leu Asp Ala Val Ala Leu Glu Arg Trp Pro Arg Asp Gly 
945                 950                 955                 960 


Pro Ala Leu Ser Gln Tyr His Val Tyr Val Arg Ala Pro Ala Arg Pro 
                965                 970                 975     


Asp Ala Gln Ala Val Val Arg Trp Pro Asp Ser Ala Val Thr Glu Gly 
            980                 985                 990         


Leu Ala Arg Ala Val Phe Ala Ser  Ser Arg Thr Phe Gly  Pro Ala Ser 
        995                 1000                 1005             


Phe Ala  Arg Ile Glu Thr Ala  Phe Ala Asn Leu Tyr  Pro Gly Glu 
    1010                 1015                 1020             


Gln Pro  Leu Cys Leu Cys Arg  Gly Gly Asn Val Ala  Tyr Thr Val 
    1025                 1030                 1035             


Cys Thr  Arg Ala Gly Pro Lys  Thr Arg Val Pro Leu  Ser Pro Arg 
    1040                 1045                 1050             


Glu Tyr  Arg Gln Tyr Val Leu  Pro Gly Phe Asp Gly  Cys Lys Asp 
    1055                 1060                 1065             


Leu Ala  Arg Gln Ser Arg Gly  Leu Gly Leu Gly Ala  Ala Asp Phe 
    1070                 1075                 1080             


Val Asp  Glu Ala Ala His Ser  His Arg Ala Ala Asn  Arg Trp Gly 
    1085                 1090                 1095             


Leu Gly  Ala Ala Leu Arg Pro  Val Phe Leu Pro Glu  Gly Arg Arg 
    1100                 1105                 1110             


Pro Gly  Ala Ala Gly Pro Glu  Ala Gly Asp Val Pro  Thr Trp Ala 
    1115                 1120                 1125             


Arg Val  Phe Cys Arg His Ala  Leu Leu Glu Pro Asp  Pro Ala Ala 
    1130                 1135                 1140             


Glu Pro  Leu Val Leu Pro Pro  Val Ala Gly Arg Ser  Val Ala Leu 
    1145                 1150                 1155             


Tyr Ala  Ser Ala Asp Glu Ala  Arg Asn Ala Leu Pro  Pro Ile Pro 
    1160                 1165                 1170             


Arg Val  Met Trp Pro Pro Gly  Phe Gly Ala Ala Glu  Thr Val Leu 
    1175                 1180                 1185             


Glu Gly  Ser Asp Gly Thr Arg  Phe Val Phe Gly His  His Gly Gly 
    1190                 1195                 1200             


Ser Glu  Arg Pro Xaa Glu Thr  Gln Ala Gly Arg Gln  Arg Arg Thr 
    1205                 1210                 1215             


Ala Asp  Asp Arg Glu His Ala  Leu Glu Xaa Asp Asp  Trp Glu Val 
    1220                 1225                 1230             


Gly Cys  Glu Asp Ala Trp Asp  Ser Glu Glu Gly Gly  Gly Asp Asp 
    1235                 1240                 1245             


Gly Asp  Ala Pro Gly Ser Ser  Phe Gly Val Ser Ile  Val Ser Val 
    1250                 1255                 1260             


Ala Pro  Gly Val Leu Arg Asp  Arg Arg Val Gly Leu  Arg Pro Ala 
    1265                 1270                 1275             


Val Lys  Val Glu Leu Leu Ser  Ser Ser Ser Ser Ser  Glu Asp Glu 
    1280                 1285                 1290             


Asp Asp  Val Trp Gly Gly Arg  Gly Gly Arg Ser Pro  Pro Gln Ser 
    1295                 1300                 1305             


Arg Gly  
    1310 


<210>  15
<211>  1310
<212>  PRT
<213>  Varicella Zoster Virus

<400>  15

Met Asp Thr Pro Pro Met Gln Arg Ser Thr Pro Gln Arg Ala Gly Ser 
1               5                   10                  15      


Pro Asp Thr Leu Glu Leu Met Asp Leu Leu Asp Ala Ala Ala Ala Ala 
            20                  25                  30          


Ala Glu His Arg Ala Arg Val Val Thr Ser Ser Gln Pro Asp Asp Leu 
        35                  40                  45              


Leu Phe Gly Glu Asn Gly Val Met Val Gly Arg Glu His Glu Ile Val 
    50                  55                  60                  


Ser Ile Pro Ser Val Ser Gly Leu Gln Pro Glu Pro Arg Thr Glu Asp 
65                  70                  75                  80  


Val Gly Glu Glu Leu Thr Gln Asp Asp Tyr Val Cys Glu Asp Gly Gln 
                85                  90                  95      


Asp Leu Met Gly Ser Pro Val Ile Pro Leu Ala Glu Val Phe His Thr 
            100                 105                 110         


Arg Phe Ser Glu Ala Gly Ala Arg Glu Pro Thr Gly Ala Asp Arg Ser 
        115                 120                 125             


Leu Glu Thr Val Ser Leu Gly Thr Lys Leu Ala Arg Ser Pro Lys Pro 
    130                 135                 140                 


Pro Met Asn Asp Gly Glu Thr Gly Arg Gly Thr Thr Pro Pro Phe Pro 
145                 150                 155                 160 


Gln Ala Phe Ser Pro Val Ser Pro Ala Ser Pro Val Gly Asp Ala Ala 
                165                 170                 175     


Gly Asn Asp Gln Arg Glu Asp Gln Arg Ser Ile Pro Arg Gln Thr Thr 
            180                 185                 190         


Arg Gly Asn Ser Pro Gly Leu Pro Ser Val Val His Arg Asp Arg Gln 
        195                 200                 205             


Thr Gln Ser Ile Ser Gly Lys Lys Pro Gly Asp Glu Gln Ala Gly His 
    210                 215                 220                 


Ala His Ala Ser Gly Asp Gly Val Val Leu Gln Lys Thr Gln Arg Pro 
225                 230                 235                 240 


Ala Gln Gly Lys Ser Pro Lys Lys Lys Thr Leu Lys Val Lys Val Pro 
                245                 250                 255     


Leu Pro Ala Arg Lys Pro Gly Gly Pro Val Pro Gly Pro Val Glu Gln 
            260                 265                 270         


Leu Tyr His Val Leu Ser Asp Ser Val Pro Ala Lys Gly Ala Lys Ala 
        275                 280                 285             


Asp Leu Pro Phe Glu Thr Asp Asp Thr Arg Pro Arg Lys His Asp Ala 
    290                 295                 300                 


Arg Gly Ile Thr Pro Arg Val Pro Gly Arg Ser Ser Gly Gly Lys Pro 
305                 310                 315                 320 


Arg Ala Phe Leu Ala Leu Pro Gly Arg Ser His Ala Pro Asp Pro Ile 
                325                 330                 335     


Glu Asp Asp Ser Pro Val Glu Lys Lys Pro Lys Ser Arg Glu Phe Val 
            340                 345                 350         


Ser Ser Ser Ser Ser Ser Ser Ser Trp Gly Ser Ser Ser Glu Asp Glu 
        355                 360                 365             


Asp Asp Glu Pro Arg Arg Val Ser Val Gly Ser Glu Thr Thr Gly Ser 
    370                 375                 380                 


Arg Ser Gly Arg Glu His Ala Pro Ser Pro Ser Asn Ser Asp Asp Ser 
385                 390                 395                 400 


Asp Ser Asn Asp Gly Gly Ser Thr Lys Gln Asn Ile Gln Pro Gly Tyr 
                405                 410                 415     


Arg Ser Ile Ser Gly Pro Asp Pro Arg Ile Arg Lys Thr Lys Arg Leu 
            420                 425                 430         


Ala Gly Glu Pro Gly Arg Gln Arg Gln Lys Ser Phe Ser Leu Pro Arg 
        435                 440                 445             


Ser Arg Thr Pro Ile Ile Pro Pro Val Ser Gly Pro Leu Met Met Pro 
    450                 455                 460                 


Asp Gly Ser Pro Trp Pro Gly Ser Ala Pro Leu Pro Ser Asn Arg Val 
465                 470                 475                 480 


Arg Phe Gly Pro Ser Gly Glu Thr Arg Glu Gly His Trp Glu Asp Glu 
                485                 490                 495     


Ala Val Arg Ala Ala Arg Ala Arg Tyr Glu Ala Ser Thr Glu Pro Val 
            500                 505                 510         


Pro Leu Tyr Val Pro Glu Leu Gly Asp Pro Ala Arg Gln Tyr Arg Ala 
        515                 520                 525             


Leu Ile Asn Leu Ile Tyr Cys Pro Asp Arg Asp Pro Ile Ala Trp Leu 
    530                 535                 540                 


Gln Asn Pro Lys Leu Thr Gly Val Asn Ser Ala Leu Asn Gln Phe Tyr 
545                 550                 555                 560 


Gln Lys Leu Leu Pro Pro Gly Arg Ala Gly Thr Ala Val Thr Gly Ser 
                565                 570                 575     


Val Ala Ser Pro Val Pro His Val Gly Glu Ala Met Ala Thr Gly Glu 
            580                 585                 590         


Ala Leu Trp Ala Leu Pro His Ala Ala Ala Ala Val Ala Met Ser Arg 
        595                 600                 605             


Arg Tyr Asp Arg Ala Gln Lys His Phe Ile Leu Gln Ser Leu Arg Arg 
    610                 615                 620                 


Ala Phe Ala Ser Met Ala Tyr Pro Glu Ala Thr Gly Ser Ser Pro Ala 
625                 630                 635                 640 


Ala Arg Ile Ser Arg Gly His Pro Ser Pro Thr Thr Pro Ala Thr Gln 
                645                 650                 655     


Ala Pro Asp Pro Gln Pro Ser Ala Ala Ala Arg Ser Leu Ser Val Cys 
            660                 665                 670         


Pro Pro Asp Asp Arg Leu Arg Thr Pro Arg Lys Arg Lys Ser Gln Pro 
        675                 680                 685             


Val Glu Ser Arg Ser Leu Leu Asp Lys Ile Arg Glu Thr Pro Val Ala 
    690                 695                 700                 


Asp Ala Arg Val Ala Asp Asp His Val Val Ser Lys Ala Lys Arg Arg 
705                 710                 715                 720 


Val Ser Glu Pro Val Thr Ile Thr Ser Gly Pro Val Val Asp Pro Pro 
                725                 730                 735     


Ala Val Ile Thr Met Pro Leu Asp Gly Pro Ala Pro Asn Gly Gly Phe 
            740                 745                 750         


Arg Arg Ile Pro Arg Gly Ala Leu His Thr Pro Val Pro Ser Asp Gln 
        755                 760                 765             


Ala Arg Lys Ala Tyr Cys Thr Pro Glu Thr Ile Ala Arg Leu Val Asp 
    770                 775                 780                 


Asp Pro Leu Phe Pro Thr Ala Trp Arg Pro Ala Leu Ser Phe Asp Pro 
785                 790                 795                 800 


Gly Ala Leu Ala Glu Ile Ala Ala Arg Arg Pro Gly Gly Gly Asp Arg 
                805                 810                 815     


Arg Phe Gly Pro Pro Ser Gly Val Glu Ala Leu Arg Arg Arg Cys Ala 
            820                 825                 830         


Trp Met Arg Gln Ile Pro Asp Pro Glu Asp Val Arg Leu Leu Ile Ile 
        835                 840                 845             


Tyr Asp Pro Leu Pro Gly Glu Asp Ile Asn Gly Pro Leu Glu Ser Thr 
    850                 855                 860                 


Leu Ala Thr Asp Pro Gly Pro Ser Trp Ser Pro Ser Arg Gly Gly Leu 
865                 870                 875                 880 


Ser Val Val Leu Ala Ala Leu Ser Asn Arg Leu Cys Leu Pro Ser Thr 
                885                 890                 895     


His Ala Trp Ala Gly Asn Trp Thr Gly Pro Pro Asp Val Ser Ala Leu 
            900                 905                 910         


Asn Ala Arg Gly Val Leu Leu Leu Ser Thr Arg Asp Leu Ala Phe Ala 
        915                 920                 925             


Gly Ala Val Glu Tyr Leu Gly Ser Arg Leu Ala Ser Ala Arg Arg Arg 
    930                 935                 940                 


Leu Leu Val Leu Asp Ala Val Ala Leu Glu Arg Trp Pro Arg Asp Gly 
945                 950                 955                 960 


Pro Ala Leu Ser Gln Tyr His Val Tyr Val Arg Ala Pro Ala Arg Pro 
                965                 970                 975     


Asp Ala Gln Ala Val Val Arg Trp Pro Asp Ser Ala Val Thr Glu Gly 
            980                 985                 990         


Leu Ala Arg Ala Val Phe Ala Ser  Ser Arg Thr Phe Gly  Pro Ala Ser 
        995                 1000                 1005             


Phe Ala  Arg Ile Glu Thr Ala  Phe Ala Asn Leu Tyr  Pro Gly Glu 
    1010                 1015                 1020             


Gln Pro  Leu Cys Leu Cys Arg  Gly Gly Asn Val Ala  Tyr Thr Val 
    1025                 1030                 1035             


Cys Thr  Arg Ala Gly Pro Lys  Thr Arg Val Pro Leu  Ser Pro Arg 
    1040                 1045                 1050             


Glu Tyr  Arg Gln Tyr Val Leu  Pro Gly Phe Asp Gly  Cys Lys Asp 
    1055                 1060                 1065             


Leu Ala  Arg Gln Ser Arg Gly  Leu Gly Leu Gly Ala  Ala Asp Phe 
    1070                 1075                 1080             


Val Asp  Glu Ala Ala His Ser  His Arg Ala Ala Asn  Arg Trp Gly 
    1085                 1090                 1095             


Leu Gly  Ala Ala Leu Arg Pro  Val Phe Leu Pro Glu  Gly Arg Arg 
    1100                 1105                 1110             


Pro Gly  Ala Ala Gly Pro Glu  Ala Gly Asp Val Pro  Thr Trp Ala 
    1115                 1120                 1125             


Arg Val  Phe Cys Arg His Ala  Leu Leu Glu Pro Asp  Pro Ala Ala 
    1130                 1135                 1140             


Glu Pro  Leu Val Leu Pro Pro  Val Ala Gly Arg Ser  Val Ala Leu 
    1145                 1150                 1155             


Tyr Ala  Ser Ala Asp Glu Ala  Arg Asn Ala Leu Pro  Pro Ile Pro 
    1160                 1165                 1170             


Arg Val  Met Trp Pro Pro Gly  Phe Gly Ala Ala Glu  Thr Val Leu 
    1175                 1180                 1185             


Glu Gly  Ser Asp Gly Thr Arg  Phe Val Phe Gly His  His Gly Gly 
    1190                 1195                 1200             


Ser Glu  Arg Pro Ser Glu Thr  Gln Ala Gly Arg Gln  Arg Arg Thr 
    1205                 1210                 1215             


Ala Asp  Asp Arg Glu His Ala  Leu Glu Leu Asp Asp  Trp Glu Val 
    1220                 1225                 1230             


Gly Cys  Glu Asp Ala Trp Asp  Ser Glu Glu Gly Gly  Gly Asp Asp 
    1235                 1240                 1245             


Gly Asp  Ala Pro Gly Ser Ser  Phe Gly Val Ser Ile  Val Ser Val 
    1250                 1255                 1260             


Ala Pro  Gly Val Leu Arg Asp  Arg Arg Val Gly Leu  Arg Pro Ala 
    1265                 1270                 1275             


Val Lys  Val Glu Leu Leu Ser  Ser Ser Ser Ser Ser  Glu Asp Glu 
    1280                 1285                 1290             


Asp Asp  Val Trp Gly Gly Arg  Gly Gly Arg Ser Pro  Pro Gln Ser 
    1295                 1300                 1305             


Arg Gly  
    1310 


<210>  16
<211>  3933
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VZV Orf IE62 for expression in insect cells

<400>  16
atggacaccc cccccatgca gcgttccacc ccccagcgtg ctggttcccc cgacaccctc       60

gagctgatgg acctgctgga cgctgctgct gccgctgccg agcaccgtgc tcgtgtggtg      120

acctcctccc agcccgacga cctgctgttc ggcgagaacg gtgtcatggt cggtcgtgag      180

cacgagatcg tgtccatccc ttccgtgtcc ggtctgcagc ccgagccccg taccgaggac      240

gtgggcgaag agctgaccca ggacgactac gtgtgcgagg acggccagga cctgatgggt      300

tcccccgtga tccccctggc tgaggtgttc cacacccgtt tctccgaggc tggtgctcgt      360

gagcccaccg gtgctgaccg ttccctcgag accgtgtccc tgggcaccaa gctggctcgt      420

tcccccaagc cccccatgaa cgacggcgag accggtcgtg gcaccacccc ccccttccct      480

caggctttct cccctgtgtc ccccgcttcc cccgtgggtg acgctgctgg taacgaccag      540

cgtgaggacc agcgttccat ccctcgtcag accacccgtg gtaactcccc cggtctgccc      600

tccgtggtgc accgtgaccg tcagacccag tccatctccg gcaagaagcc cggcgacgag      660

caggctggtc acgctcacgc ttccggtgac ggtgttgtgc tgcaaaaaac ccaacgtccc      720

gcccagggaa agtctcccaa gaagaaaacc ctgaaggtca aggtgcccct gcccgctcgt      780

aagcccggtg gtcccgtgcc cggtcccgtg gagcagctgt accacgtgct gtccgactcc      840

gtgcccgcta agggtgctaa ggctgacctg cctttcgaga ccgacgacac ccgtccccgt      900

aagcatgacg ctaggggcat cactcctcgt gtgcccggtc gttcctccgg tggcaagccc      960

cgtgctttcc tggctctgcc tggtcgttcc cacgctcccg accccatcga ggacgactcc     1020

cccgtggaga agaagcccaa gtcccgcgag ttcgtgtcct cctcctccag ctcctcctcc     1080

tggggttcca gctccgagga cgaggacgac gagccccgtc gtgtgtccgt gggttccgag     1140

accaccggtt cccgttccgg tcgcgagcac gccccctccc catccaactc tgacgactcc     1200

gactccaacg acggtggttc caccaagcag aacatccagc ccggctaccg ttccatttct     1260

ggtcccgacc cccgtatccg taagaccaag cgtctggctg gcgaaccagg ccgtcagcgt     1320

cagaagtcct tctccctgcc ccgttcccgt acccctatca tccctcctgt ctccggccct     1380

ctgatgatgc ccgacggttc cccctggccc ggttccgctc ccctgccctc caaccgtgtg     1440

cgtttcggtc cctccggcga gacccgtgag ggccactggg aggacgaggc tgtgcgtgct     1500

gctcgtgctc gttacgaggc ttccaccgag cccgtgcccc tgtacgtgcc cgaactgggt     1560

gaccctgccc gtcagtaccg tgctctgatc aacctgatct actgccccga ccgtgacccc     1620

atcgcttggc tgcagaaccc caagctgacc ggtgtcaact ccgctctgaa ccagttctac     1680

cagaagctgc tgccccctgg tcgtgctggc accgctgtga ccggttccgt ggcttcccct     1740

gtgccccacg tgggagaggc tatggctacc ggcgaggctc tgtgggctct gcctcacgct     1800

gccgccgctg tggctatgtc ccgtcgttac gaccgtgctc agaagcactt catcctgcag     1860

tccctgcgtc gtgctttcgc ttccatggct taccccgagg ctaccggttc ctcccccgct     1920

gctcgtatct cccgtggtca cccctccccc accacccccg ctacccaggc tccagacccc     1980

caaccctctg ctgctgctcg ttccctgtcc gtgtgccccc ctgacgaccg tctgcgtacc     2040

ccccgtaagc gcaagtccca gcccgtggag tcccgttccc tgctggacaa gatccgtgag     2100

accccagtgg ctgacgctcg cgtggctgac gaccacgtcg tgtccaaggc taagaggcgc     2160

gtgtccgagc ctgtgaccat cacctccggt cctgtggtgg acccccctgc tgtgatcacc     2220

atgcccctgg acggtcccgc tcccaacggt ggtttccgtc gtatccctcg tggtgctctg     2280

cacacccccg tgccctccga ccaggctcgt aaggcttact gcacccccga gaccatcgct     2340

cgtctggtgg acgaccccct gttccccacc gcttggcgtc ctgctctgtc cttcgacccc     2400

ggtgctctgg ctgagatcgc tgctcgccgt cccggtggcg gtgatcgtcg cttcggtcct     2460

ccctccggtg tcgaggctct gcgtcgtcgt tgcgcttgga tgcgtcagat ccccgaccct     2520

gaggacgtgc gcctgctgat catctacgac cctctgcccg gcgaggacat caacggtcct     2580

ctcgagtcca ccctggctac cgaccccggt ccctcctggt ccccctcccg tggtggtctg     2640

tccgtggtgc tggctgccct gtccaaccgt ctgtgcctgc cttccaccca cgcttgggct     2700

ggtaactgga ccggtccccc cgacgtgtcc gccctgaacg ctcgcggtgt cttgctcctg     2760

tccacccgtg atctggcttt cgctggtgct gtggagtacc tgggttcccg tctggcttcc     2820

gctcgtcgtc gtctgctggt cctggacgct gtggctctcg agcgttggcc ccgtgacggt     2880

ccagccctgt ctcaatacca cgtgtacgtg cgcgctcccg ctcgtcccga cgctcaggct     2940

gtggtgcgct ggcccgactc cgctgtcacc gagggtctgg ctcgtgctgt gttcgcttcc     3000

tcccgtacct tcggtcccgc ttccttcgct cgtatcgaga ccgctttcgc taacctgtac     3060

cccggcgagc agcccctgtg cctgtgccgt ggtggtaacg tggcttacac cgtgtgcacc     3120

cgtgctggtc ccaagacccg tgtgcctctg tccccccgtg agtaccgcca gtacgtgctg     3180

cccggtttcg acggttgcaa ggacctggct cgtcagtccc gcggtctggg tctgggtgct     3240

gctgacttcg tcgacgaggc tgctcactcc caccgtgctg ctaaccgttg gggcctgggc     3300

gctgctctgc gtcccgtgtt cctgcccgag ggtcgtcgtc ctggtgctgc tggtcccgag     3360

gctggcgacg tgcccacctg ggctcgtgtg ttctgccgtc acgctctgct cgagcccgac     3420

cctgctgccg agcctctggt gctgcccccc gtggctggtc gttctgtggc tctgtacgct     3480

tccgccgacg aggctcgcaa cgctctgccc cccatccccc gtgtgatgtg gccccctggt     3540

ttcggcgctg ctgagaccgt cctcgagggt tccgacggca cccgtttcgt gttcggtcac     3600

cacggcggtt ccgagcgtcc ctccgagacc caggctggtc gccagcgccg taccgctgac     3660

gaccgtgagc acgctctcga gctggacgac tgggaggtcg gctgcgagga cgcttgggac     3720

tccgaagagg gtggtggcga cgacggtgac gctcccggct cctccttcgg tgtctccatc     3780

gtgtccgtgg ctcccggtgt cctgcgtgac cgtcgtgtgg gtctgcgtcc tgctgtgaag     3840

gtggagctgc tgtcctcctc ttcctcttct gaggatgagg atgacgtgtg gggtggtcgt     3900

ggtggtcgct ccccccctca gtcccgtggt taa                                  3933


<210>  17
<211>  1608
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VZV gE DeltaTMCT for expression in insect cells

<400>  17
atggtgtccg ctatcgtgct gtacgtgctg ctggctgctg ctgctcactc cgctttcgct       60

cgtatcacca accccgtgcg tgcttccgtg ctgcgttacg acgacttcca caccgacgag      120

gacaagctgg acaccaactc cgtgtacgag ccctactacc actccgacca cgctgagtcc      180

tcttgggtga accgtggcga gtcctcccgt aaggcttacg accacaactc cccctacatc      240

tggccccgta acgactacga cggtttcctc gagaacgctc acgagcacca cggtgtctac      300

aaccagggtc gtggtatcga ctccggcgag cgtctgatgc agcccaccca gatgtccgct      360

caggaggacc tgggcgacga caccggtatc cacgtgatcc ccaccctgaa cggtgacgac      420

cgtcacaaga tcgtgaacgt ggaccagcgc cagtacggtg acgtgttcaa gggtgacctg      480

aaccccaagc cccagggcca gcgtctgatc gaggtgtccg tggaggagaa ccaccccttc      540

accctgcgtg ctcccatcca gcgtatctac ggtgtccgtt acaccgagac ctggtccttc      600

ctcccctccc tgacctgcac cggtgacgct gctcccgcta tccagcacat ctgcctgaag      660

cacaccacct gcttccagga cgtggtggtg gacgtggact gcgctgagaa caccaaggag      720

gaccagctgg ctgagatctc ctacaggttc cagggcaaga aggaggctga ccagccctgg      780

atcgtggtga acacctccac cctgttcgac gagctggagc tggacccccc cgagatcgag      840

cccggtgtcc tgaaggtgct gcgtaccgag aagcagtacc tgggcgtgta catctggaac      900

atgcgtggtt ccgacggcac ctccacctac gctaccttcc tcgtgacctg gaagggtgac      960

gaaaagaccc gtaaccccac ccccgctgtg accccccagc cccgtggtgc tgaattccat     1020

atgtggaact accactctca cgtgttctcc gtgggtgaca ccttctccct ggctatgcac     1080

ctgcagtaca agatccacga ggctcccttc gacctgctgc tcgagtggct gtacgtgccc     1140

atcgacccca cctgccagcc catgcgcctg tactccacct gcctgtacca ccccaacgct     1200

ccccagtgcc tgtcccacat gaactccggt tgcaccttca cctcccccca cctggcccag     1260

cgtgtggctt ccaccgtgta ccagaactgc gagcacgctg acaactacac cgcttactgc     1320

ctgggtatca gccacatgga gccttccttc ggtctgatcc tgcacgacgg tggcaccacc     1380

ctgaagttcg tggacacccc cgagtccctg tccggtctgt acgtgttcgt ggtgtacttc     1440

aacggtcacg tggaggctgt cgcttacacc gtggtgtcca ccgtggacca cttcgtgaac     1500

gctatcgagg agcgtggttt cccccccacc gctggccagc cccctgctac caccaagccc     1560

aaggagatca cccccgtcaa ccccggcacc tcccctctgc tgcgctaa                  1608


<210>  18
<211>  535
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VZV gE DeltaTMCT

<400>  18

Met Val Ser Ala Ile Val Leu Tyr Val Leu Leu Ala Ala Ala Ala His 
1               5                   10                  15      


Ser Ala Phe Ala Arg Ile Thr Asn Pro Val Arg Ala Ser Val Leu Arg 
            20                  25                  30          


Tyr Asp Asp Phe His Thr Asp Glu Asp Lys Leu Asp Thr Asn Ser Val 
        35                  40                  45              


Tyr Glu Pro Tyr Tyr His Ser Asp His Ala Glu Ser Ser Trp Val Asn 
    50                  55                  60                  


Arg Gly Glu Ser Ser Arg Lys Ala Tyr Asp His Asn Ser Pro Tyr Ile 
65                  70                  75                  80  


Trp Pro Arg Asn Asp Tyr Asp Gly Phe Leu Glu Asn Ala His Glu His 
                85                  90                  95      


His Gly Val Tyr Asn Gln Gly Arg Gly Ile Asp Ser Gly Glu Arg Leu 
            100                 105                 110         


Met Gln Pro Thr Gln Met Ser Ala Gln Glu Asp Leu Gly Asp Asp Thr 
        115                 120                 125             


Gly Ile His Val Ile Pro Thr Leu Asn Gly Asp Asp Arg His Lys Ile 
    130                 135                 140                 


Val Asn Val Asp Gln Arg Gln Tyr Gly Asp Val Phe Lys Gly Asp Leu 
145                 150                 155                 160 


Asn Pro Lys Pro Gln Gly Gln Arg Leu Ile Glu Val Ser Val Glu Glu 
                165                 170                 175     


Asn His Pro Phe Thr Leu Arg Ala Pro Ile Gln Arg Ile Tyr Gly Val 
            180                 185                 190         


Arg Tyr Thr Glu Thr Trp Ser Phe Leu Pro Ser Leu Thr Cys Thr Gly 
        195                 200                 205             


Asp Ala Ala Pro Ala Ile Gln His Ile Cys Leu Lys His Thr Thr Cys 
    210                 215                 220                 


Phe Gln Asp Val Val Val Asp Val Asp Cys Ala Glu Asn Thr Lys Glu 
225                 230                 235                 240 


Asp Gln Leu Ala Glu Ile Ser Tyr Arg Phe Gln Gly Lys Lys Glu Ala 
                245                 250                 255     


Asp Gln Pro Trp Ile Val Val Asn Thr Ser Thr Leu Phe Asp Glu Leu 
            260                 265                 270         


Glu Leu Asp Pro Pro Glu Ile Glu Pro Gly Val Leu Lys Val Leu Arg 
        275                 280                 285             


Thr Glu Lys Gln Tyr Leu Gly Val Tyr Ile Trp Asn Met Arg Gly Ser 
    290                 295                 300                 


Asp Gly Thr Ser Thr Tyr Ala Thr Phe Leu Val Thr Trp Lys Gly Asp 
305                 310                 315                 320 


Glu Lys Thr Arg Asn Pro Thr Pro Ala Val Thr Pro Gln Pro Arg Gly 
                325                 330                 335     


Ala Glu Phe His Met Trp Asn Tyr His Ser His Val Phe Ser Val Gly 
            340                 345                 350         


Asp Thr Phe Ser Leu Ala Met His Leu Gln Tyr Lys Ile His Glu Ala 
        355                 360                 365             


Pro Phe Asp Leu Leu Leu Glu Trp Leu Tyr Val Pro Ile Asp Pro Thr 
    370                 375                 380                 


Cys Gln Pro Met Arg Leu Tyr Ser Thr Cys Leu Tyr His Pro Asn Ala 
385                 390                 395                 400 


Pro Gln Cys Leu Ser His Met Asn Ser Gly Cys Thr Phe Thr Ser Pro 
                405                 410                 415     


His Leu Ala Gln Arg Val Ala Ser Thr Val Tyr Gln Asn Cys Glu His 
            420                 425                 430         


Ala Asp Asn Tyr Thr Ala Tyr Cys Leu Gly Ile Ser His Met Glu Pro 
        435                 440                 445             


Ser Phe Gly Leu Ile Leu His Asp Gly Gly Thr Thr Leu Lys Phe Val 
    450                 455                 460                 


Asp Thr Pro Glu Ser Leu Ser Gly Leu Tyr Val Phe Val Val Tyr Phe 
465                 470                 475                 480 


Asn Gly His Val Glu Ala Val Ala Tyr Thr Val Val Ser Thr Val Asp 
                485                 490                 495     


His Phe Val Asn Ala Ile Glu Glu Arg Gly Phe Pro Pro Thr Ala Gly 
            500                 505                 510         


Gln Pro Pro Ala Thr Thr Lys Pro Lys Glu Ile Thr Pro Val Asn Pro 
        515                 520                 525             


Gly Thr Ser Pro Leu Leu Arg 
    530                 535 


<210>  19
<211>  816
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Codon-optimized VZV gI DeltaTMCT for expression in insect cells

<400>  19
atgttcctca tccagtgcct gatctccgct gtgatcttct acatccaagt gaccaacgct       60

ctgatcttca agggtgacca cgtgtccctg caggtcaact cctccctgac ctccatcctg      120

atccccatgc agaacgacaa ctacaccgag atcaagggcc agctggtgtt catcggcgag      180

cagctgccca ccggcaccaa ctactccggc accctcgagc tgctgtacgc tgacaccgtc      240

gctttctgct tccgttccgt gcaggtgatc cgttacgacg gttgcccccg tatccgtacc      300

tccgctttca tctcctgccg ttacaagcac tcctggcact acggtaactc caccgaccgt      360

atctccaccg agcccgacgc tggtgtcatg ctgaagatca ccaagcccgg tatcaacgac      420

gctggcgtgt acgtgctgct ggtccgtctg gaccactccc gttccaccga cggtttcatc      480

ctgggtgtca acgtgtacac cgctggttcc caccacaaca tccacggtgt catctacacc      540

tccccctccc tgcagaacgg ttactccacc cgtgctctgt tccagcaggc tcgtctgtgc      600

gacctgcccg ctacccccaa gggttccggc acctccctct tccagcacat gctggacctg      660

cgtgctggca agtccctcga ggacaacccc tggctgcacg aggacgtggt gaccaccgag      720

accaagtccg tggtgaagga aggtatcgag aaccacgtgt accccaccga catgtccacc      780

ctgcccgaga agtccctgaa cgaccccccc gagtaa                                816


<210>  20
<211>  271
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  VZV gI Delta TMCT

<400>  20

Met Phe Leu Ile Gln Cys Leu Ile Ser Ala Val Ile Phe Tyr Ile Gln 
1               5                   10                  15      


Val Thr Asn Ala Leu Ile Phe Lys Gly Asp His Val Ser Leu Gln Val 
            20                  25                  30          


Asn Ser Ser Leu Thr Ser Ile Leu Ile Pro Met Gln Asn Asp Asn Tyr 
        35                  40                  45              


Thr Glu Ile Lys Gly Gln Leu Val Phe Ile Gly Glu Gln Leu Pro Thr 
    50                  55                  60                  


Gly Thr Asn Tyr Ser Gly Thr Leu Glu Leu Leu Tyr Ala Asp Thr Val 
65                  70                  75                  80  


Ala Phe Cys Phe Arg Ser Val Gln Val Ile Arg Tyr Asp Gly Cys Pro 
                85                  90                  95      


Arg Ile Arg Thr Ser Ala Phe Ile Ser Cys Arg Tyr Lys His Ser Trp 
            100                 105                 110         


His Tyr Gly Asn Ser Thr Asp Arg Ile Ser Thr Glu Pro Asp Ala Gly 
        115                 120                 125             


Val Met Leu Lys Ile Thr Lys Pro Gly Ile Asn Asp Ala Gly Val Tyr 
    130                 135                 140                 


Val Leu Leu Val Arg Leu Asp His Ser Arg Ser Thr Asp Gly Phe Ile 
145                 150                 155                 160 


Leu Gly Val Asn Val Tyr Thr Ala Gly Ser His His Asn Ile His Gly 
                165                 170                 175     


Val Ile Tyr Thr Ser Pro Ser Leu Gln Asn Gly Tyr Ser Thr Arg Ala 
            180                 185                 190         


Leu Phe Gln Gln Ala Arg Leu Cys Asp Leu Pro Ala Thr Pro Lys Gly 
        195                 200                 205             


Ser Gly Thr Ser Leu Phe Gln His Met Leu Asp Leu Arg Ala Gly Lys 
    210                 215                 220                 


Ser Leu Glu Asp Asn Pro Trp Leu His Glu Asp Val Val Thr Thr Glu 
225                 230                 235                 240 


Thr Lys Ser Val Val Lys Glu Gly Ile Glu Asn His Val Tyr Pro Thr 
                245                 250                 255     


Asp Met Ser Thr Leu Pro Glu Lys Ser Leu Asn Asp Pro Pro Glu 
            260                 265                 270     


