                               SEQUENCE LISTING                               

<110> IRM LLC

<120> ANTAGONISTS OF PROTEASE ACTIVATED RECEPTOR-1 (PAR1)

<130> P1311PC00

<140>
<141>

<150> 60/950,290
<151> 2007-07-17

<160> 70                            

<170> PatentIn Ver. 3.3

<210> 1
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 1
Ser Phe Leu Leu Arg Asn Pro Asn Asp Lys Tyr Glu Pro Phe Trp Glu  
  1               5                  10                  15    

Asp Glu Glu Lys Asn Glu Ser Gly Leu Thr Glu                      
             20                  25        


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (1)
<223> /replace="Asn"

<220> 
<221> VARIANT
<222> (3)
<223> /replace="Val"

<220> 
<221> VARIANT
<222> (4)
<223> /replace="Phe"

<220> 
<221> VARIANT
<222> (5)
<223> /replace="His"

<400> 2
Ser Tyr Tyr Met Asn                                              
  1               5


<210> 3
<211> 5
<212> PRT
<213> Homo sapiens

<400> 3
Ser Tyr Tyr Met His                                              
  1               5


<210> 4
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 4
Ser Tyr Tyr Met Asn                                              
  1               5


<210> 5
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 5
Asn Tyr Val Phe Asn                                              
  1               5


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (1)
<223> /replace="Val"

<220> 
<221> VARIANT
<222> (3)
<223> /replace="Asp"

<220> 
<221> VARIANT
<222> (5)
<223> /replace="His"

<220> 
<221> VARIANT
<222> (6)
<223> /replace="Gly"

<220> 
<221> VARIANT
<222> (8)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (10)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (12)
<223> /replace="Asn"

<220> 
<221> VARIANT
<222> (16)
<223> /replace="Gln"

<400> 6
Ile Ile Asn Pro Ser Ser Gly Arg Thr Arg Tyr Ala Gln Lys Phe Lys  
  1               5                  10                  15    

Gly                                                              
   


<210> 7
<211> 17
<212> PRT
<213> Homo sapiens

<400> 7
Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln  
  1               5                  10                  15    

Gly                                                              
   


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 8
Val Ile Asp Pro His Gly Gly Arg Thr Arg Tyr Asn Gln Lys Phe Lys  
  1               5                  10                  15    

Gly                                                              
   


<210> 9
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 9
Val Ile Asn Pro His Ser Gly Arg Thr Arg Tyr Asn Gln Lys Phe Lys  
  1               5                  10                  15    

Gly                                                              
   


<210> 10
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (3)
<223> /replace="Ile"

<220> 
<221> VARIANT
<222> (4)
<223> /replace="Tyr"

<220> 
<221> VARIANT
<222> (6)
<223> /replace="Leu" or "Pro" or "Met" or "Glu" or "Trp" or
      "Thr" or "Ser" or "Gln" or "Ala"

<220> 
<221> VARIANT
<222> (8)
<223> /replace="Phe"

<400> 10
Asp Asp Gly Pro Ser His Trp Tyr Phe Asp Val                      
  1               5                  10    


<210> 11
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 11
Asp Asp Gly Pro Ser Met Trp Tyr Phe Asp Val                      
  1               5                  10    


<210> 12
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 12
Asp Asp Gly Pro Ser Leu Trp Tyr Phe Asp Val                      
  1               5                  10    


<210> 13
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 13
Asp Asp Gly Pro Ser His Trp Tyr Phe Asp Val                      
  1               5                  10    


<210> 14
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (9)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (12)
<223> /replace="Asn"

<220> 
<221> VARIANT
<222> (16)
<223> /replace="Glu"

<400> 14
Arg Ser Ser Gln Ser Leu Leu His Arg Asn Gly Tyr Asn Tyr Leu Asp  
  1               5                  10                  15    


<210> 15
<211> 16
<212> PRT
<213> Homo sapiens

<400> 15
Arg Ser Ser Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp  
  1               5                  10                  15    


<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 16
Arg Ser Ser Gln Ser Leu Leu His Arg Asn Gly Asn Asn Tyr Leu Glu  
  1               5                  10                  15    


<210> 17
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (1)
<223> /replace="Lys"

<220> 
<221> VARIANT
<222> (2)
<223> /replace="Ile"

<220> 
<221> VARIANT
<222> (6)
<223> /replace="Phe"

<400> 17
Leu Gly Ser Asn Arg Ala Ser                                      
  1               5        


<210> 18
<211> 7
<212> PRT
<213> Homo sapiens

<400> 18
Leu Gly Ser Asn Arg Ala Ser                                      
  1               5        


<210> 19
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 19
Lys Ile Ser Asn Arg Phe Ser                                      
  1               5        


<210> 20
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (4)
<223> /replace="Asp" or "Ala" or "Val"

<220> 
<221> VARIANT
<222> (5)
<223> /replace="Arg" or "Thr" or "Ser" or "Lys"

<400> 20
Phe Gln Gly Ser His Val Pro Phe Thr                              
  1               5                


<210> 21
<211> 7
<212> PRT
<213> Homo sapiens

<400> 21
Met Gln Ala Leu Gln Thr Pro                                      
  1               5        


<210> 22
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 22
Phe Gln Gly Ser Ser Val Pro Phe Thr                              
  1               5                


<210> 23
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 23
Phe Gln Gly Ser His Val Pro Phe Thr                              
  1               5                


<210> 24
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (1)
<223> /replace="Gln"

<220> 
<221> VARIANT
<222> (16)
<223> /replace="Ala"

<220> 
<221> VARIANT
<222> (24)
<223> /replace="Ala"

<220> 
<221> VARIANT
<222> (27)
<223> /replace="Tyr"

<220> 
<221> VARIANT
<222> (30)
<223> /replace="Asn"

<400> 24
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser          
             20                  25                  30


<210> 25
<211> 30
<212> PRT
<213> Homo sapiens

<400> 25
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn          
             20                  25                  30


<210> 26
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 26
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser          
             20                  25                  30


<210> 27
<211> 14
<212> PRT
<213> Homo sapiens

<400> 27
Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly          
  1               5                  10                


<210> 28
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (6)
<223> /replace="Thr"

<220> 
<221> VARIANT
<222> (13)
<223> /replace="Ala"

<220> 
<221> VARIANT
<222> (18)
<223> /replace="Arg"

<220> 
<221> VARIANT
<222> (21)
<223> /replace="Thr"

<220> 
<221> VARIANT
<222> (23)
<223> /replace="Asp"

<400> 28
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu  
  1               5                  10                  15    

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 
<210> 29
<211> 32
<212> PRT
<213> Homo sapiens

<400> 29
Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr Met Glu  
  1               5                  10                  15    

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 
<210> 30
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 30
Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr Met Glu  
  1               5                  10                  15    

Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 
<210> 31
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 31
Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu  
  1               5                  10                  15    

Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys Ala Arg  
             20                  25                  30        

                                                                 
<210> 32
<211> 11
<212> PRT
<213> Homo sapiens

<400> 32
Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser                      
  1               5                  10    


<210> 33
<211> 23
<212> PRT
<213> Homo sapiens

<400> 33
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys                                      
             20            


<210> 34
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (11)
<223> /replace="Arg"

<400> 34
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr      
  1               5                  10                  15


<210> 35
<211> 15
<212> PRT
<213> Homo sapiens

<400> 35
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr      
  1               5                  10                  15


<210> 36
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 36
Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Arg Leu Leu Ile Tyr      
  1               5                  10                  15


<210> 37
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<220> 
<221> VARIANT
<222> (11)
<223> /replace="Ala"

<400> 37
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr  
  1               5                  10                  15    

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys  
             20                  25                  30        

                                                                 
<210> 38
<211> 32
<212> PRT
<213> Homo sapiens

<400> 38
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr  
  1               5                  10                  15    

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys  
             20                  25                  30        

                                                                 
<210> 39
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 39
Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr  
  1               5                  10                  15    

Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys  
             20                  25                  30        

                                                                 
<210> 40
<211> 10
<212> PRT
<213> Homo sapiens

<400> 40
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                          
  1               5                  10


<210> 41
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<220> 
<221> VARIANT
<222> (1)
<223> /replace="Glu"

<220> 
<221> VARIANT
<222> (16)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (24)
<223> /replace="Val"

<220> 
<221> VARIANT
<222> (27)
<223> /replace="Gly"

<220> 
<221> VARIANT
<222> (30)..(31)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (33)
<223> /replace="Val"

<220> 
<221> VARIANT
<222> (34)
<223> /replace="Phe"

<220> 
<221> VARIANT
<222> (35)
<223> /replace="His"

<220> 
<221> VARIANT
<222> (50)
<223> /replace="Ile"

<220> 
<221> VARIANT
<222> (52)
<223> /replace="Asp"

<220> 
<221> VARIANT
<222> (54)
<223> /replace="His"

<220> 
<221> VARIANT
<222> (57)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (59)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (61)
<223> /replace="Asn"

<220> 
<221> VARIANT
<222> (72)
<223> /replace="Arg"

<220> 
<221> VARIANT
<222> (79)
<223> /replace="Ala"

<220> 
<221> VARIANT
<222> (87)
<223> /replace="Thr"

<220> 
<221> VARIANT
<222> (89)
<223> /replace="Glu"

<400> 41
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Asn Tyr  
             20                  25                  30        

Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asn Pro Ser Gly Gly Arg Thr Arg Tyr Ala Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr  
 65                  70                  75                  80

Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg                                                          
       


<210> 42
<211> 98
<212> PRT
<213> Homo sapiens

<400> 42
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr  
             20                  25                  30        

Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe  
     50                  55                  60                

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Thr Ser Thr Val Tyr  
 65                  70                  75                  80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg                                                          
       


<210> 43
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 43
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr  
             20                  25                  30        

Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asp Pro His Gly Gly Arg Thr Arg Tyr Asn Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr  
 65                  70                  75                  80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg                                                          
       


<210> 44
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 44
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr  
             20                  25                  30        

Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asp Pro His Gly Gly Arg Thr Arg Tyr Asn Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg                                                          
       


<210> 45
<211> 98
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 45
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Asn Tyr  
             20                  25                  30        

Val Phe Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asn Pro His Ser Gly Arg Thr Arg Tyr Asn Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg                                                          
       


<210> 46
<211> 93
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<220> 
<221> VARIANT
<222> (32)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (35)
<223> /replace="Asn"

<220> 
<221> VARIANT
<222> (39)
<223> /replace="Glu"

<220> 
<221> VARIANT
<222> (55)
<223> /replace="Leu"

<220> 
<221> VARIANT
<222> (56)
<223> /replace="Ile"

<220> 
<221> VARIANT
<222> (60)
<223> /replace="Phe"

<400> 46
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Gln Leu Leu Ile Tyr Lys Gly Ser Asn Arg Ala Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys              
                 85                  90            


<210> 47
<211> 93
<212> PRT
<213> Homo sapiens

<400> 47
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser  
             20                  25                  30        

Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys              
                 85                  90            


<210> 48
<211> 93
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 48
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Asn Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys              
                 85                  90            


<210> 49
<211> 93
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 49
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Asn Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys              
                 85                  90            


<210> 50
<211> 93
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 50
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Asn Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys              
                 85                  90            


<210> 51
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<220> 
<221> VARIANT
<222> (1)
<223> /replace="Glu"

<220> 
<221> VARIANT
<222> (16)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (24)
<223> /replace="Val"

<220> 
<221> VARIANT
<222> (27)
<223> /replace="Gly"

<220> 
<221> VARIANT
<222> (30)..(31)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (33)
<223> /replace="Val"

<220> 
<221> VARIANT
<222> (34)
<223> /replace="Phe"

<220> 
<221> VARIANT
<222> (35)
<223> /replace="His"

<220> 
<221> VARIANT
<222> (50)
<223> /replace="Ile"

<220> 
<221> VARIANT
<222> (52)
<223> /replace="Asp"

<220> 
<221> VARIANT
<222> (54)
<223> /replace="His"

<220> 
<221> VARIANT
<222> (57)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (59)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (61)
<223> /replace="Asn"

<220> 
<221> VARIANT
<222> (72)
<223> /replace="Arg"

<220> 
<221> VARIANT
<222> (79)
<223> /replace="Ala"

<220> 
<221> VARIANT
<222> (87)
<223> /replace="Thr"

<220> 
<221> VARIANT
<222> (89)
<223> /replace="Glu"

<220> 
<221> VARIANT
<222> (104)
<223> /replace="Leu" or "His"

<400> 51
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Asn Tyr  
             20                  25                  30        

Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asn Pro Ser Gly Gly Arg Thr Arg Tyr Ala Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr  
 65                  70                  75                  80

Met Glu Leu Ser Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Asp Asp Gly Pro Ser Met Trp Tyr Phe Asp Val Trp Gly Gln  
            100                 105                 110        

Gly Thr Thr Val Thr Val Ser Ser                                  
        115                 120


<210> 52
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 52
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr  
             20                  25                  30        

Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asp Pro His Gly Gly Arg Thr Arg Tyr Asn Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Val Tyr  
 65                  70                  75                  80

Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Asp Asp Gly Pro Ser Met Trp Tyr Phe Asp Val Trp Gly Gln  
            100                 105                 110        

Gly Thr Thr Val Thr Val Ser Ser                                  
        115                 120


<210> 53
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 53
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Asn Ser Tyr  
             20                  25                  30        

Tyr Met Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asp Pro His Gly Gly Arg Thr Arg Tyr Asn Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Asp Asp Gly Pro Ser Leu Trp Tyr Phe Asp Val Trp Gly Gln  
            100                 105                 110        

Gly Thr Thr Val Thr Val Ser Ser                                  
        115                 120


<210> 54
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 54
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser  
  1               5                  10                  15    

Ser Val Lys Val Ser Cys Lys Val Ser Gly Gly Thr Phe Ser Asn Tyr  
             20                  25                  30        

Val Phe Asn Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met  
         35                  40                  45            

Gly Val Ile Asn Pro His Ser Gly Arg Thr Arg Tyr Asn Gln Lys Phe  
     50                  55                  60                

Lys Gly Arg Val Thr Met Thr Thr Asp Thr Ser Thr Ser Thr Ala Tyr  
 65                  70                  75                  80

Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys  
                 85                  90                  95    

Ala Arg Asp Asp Gly Pro Ser His Trp Tyr Phe Asp Val Trp Gly Gln  
            100                 105                 110        

Gly Thr Thr Val Thr Val Ser Ser                                  
        115                 120


<210> 55
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<220> 
<221> VARIANT
<222> (32)
<223> /replace="Ser"

<220> 
<221> VARIANT
<222> (35)
<223> /replace="Asn"

<220> 
<221> VARIANT
<222> (39)
<223> /replace="Glu"

<220> 
<221> VARIANT
<222> (55)
<223> /replace="Leu"

<220> 
<221> VARIANT
<222> (56)
<223> /replace="Ile"

<220> 
<221> VARIANT
<222> (60)
<223> /replace="Phe"

<220> 
<221> VARIANT
<222> (98)
<223> /replace="His"

<400> 55
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Gln Leu Leu Ile Tyr Lys Gly Ser Asn Arg Ala Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser Ser Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105                 110        

                                                                 
<210> 56
<211> 110
<212> PRT
<213> Homo sapiens

<400> 56
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser  
             20                  25                  30        

Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala  
                 85                  90                  95    

Leu Gln Thr Pro Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys          
            100                 105                 110


<210> 57
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 57
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Asn Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser Ser Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105                 110        

                                                                 
<210> 58
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 58
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Asn Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105                 110        

                                                                 
<210> 59
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polypeptide"

<400> 59
Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly  
  1               5                  10                  15    

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Arg  
             20                  25                  30        

Asn Gly Asn Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser  
         35                  40                  45            

Pro Arg Leu Leu Ile Tyr Lys Ile Ser Asn Arg Phe Ser Gly Val Pro  
     50                  55                  60                

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile  
 65                  70                  75                  80

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln Gly  
                 85                  90                  95    

Ser His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys  
            100                 105                 110        

                                                                 
<210> 60
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polynucleotide"

<400> 60
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60    
tcctgcaagg catctggata caccttcaac agctactata tgaactgggt gcgacaggcc 120   
ccgggacaag ggcttgagtg gatgggagtt atcgatcctc atggtggtcg tactcgttac 180   
aatcagaagt tcaagggcag agtcacgatg accacagaca catccacgag cacagtctac 240   
atggagctga gtagcctgag atctgaagac acagccgtgt actactgcgc acgcgatgat 300   
ggtccgagca tgtggtactt cgatgtgtgg ggtcagggta ccaccgtgac cgtgagctcc 360   


<210> 61
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polynucleotide"

<400> 61
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtt 60    
tcctgcaagg catctggata caccttcaac agctactata tgaactgggt gcgacaggcc 120   
ccgggacaag ggcttgagtg gatgggagtt atcgatcctc atggtggtcg tactcgttac 180   
aatcagaagt tcaagggcag agtcacgatg accacagaca catccacgag cacagcctac 240   
atggagctga ggagcctgac atctgacgac acagccgtgt actactgcgc acgcgatgat 300   
ggtccgagcc tgtggtactt cgatgtgtgg ggtcagggta ccaccgtgac cgtgagctcc 360   


<210> 62
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polynucleotide"

<400> 62
gaggtccagc tggtgcagtc tggggctgaa gtgaagaagc cggggtcctc ggtgaaggtc 60    
tcctgcaagg tctctggagg caccttcagc aactatgtct tcaattgggt gcgacaggcc 120   
cctggacaag ggcttgagtg gatgggagtt atcaatcctc atagtggtcg tactcgttac 180   
aatcagaagt tcaagggcag agtcacgatg accacagaca catccacgag cacagcctac 240   
atggagctga ggagcctgac atctgacgac acggctgtgt actactgcgc acgcgatgat 300   
ggtccgagcc actggtactt cgatgtgtgg ggtcagggta ccaccgtgac cgtgagctcc 360   


<210> 63
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polynucleotide"

<400> 63
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60    
atctcctgca ggtctagtca gagcctcctg cataggaatg gaaacaacta tttggaatgg 120   
tacctgcaga agccagggca gtctccaaga ctcctaattt ataagatttc taaccggttc 180   
tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaaaatc 240   
agcagggtgg aagctgagga tgttggggtt tactactgct ttcaaggttc ttcggttccg 300   
ttcacatttg gccaaggtac gaaactggaa attaaa                           336   


<210> 64
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polynucleotide"

<400> 64
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60    
atctcctgca ggtctagtca gagcctcctg cataggaatg gaaacaacta tttggaatgg 120   
tacctgcaga agccagggca gtctccaaga ctcctaattt ataagatttc taaccggttc 180   
tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaaaatc 240   
agcagggtgg aagctgagga tgttggagtt tactactgct ttcaaggttc tcatgttccg 300   
ttcacgtttg gccaaggtac gaaactggaa attaaa                           336   


<210> 65
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic polynucleotide"

<400> 65
gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60    
atctcctgca ggtctagtca gagcctcctg cataggaatg gaaacaacta tttggaatgg 120   
tacctgcaga agccagggca gtctccaaga ctcctaattt ataagatttc taaccggttc 180   
tctggggtcc cagacagatt cagtggcagt ggggcaggga cagatttcac actgaaaatc 240   
agcagggtgg aagctgagga tgtcggagtt tactactgct ttcaaggttc tcatgttccg 300   
ttcacgtttg gccaaggtac gaaactggaa attaaa                           336   


<210> 66
<211> 13
<212> PRT
<213> Homo sapiens

<400> 66
Asp Val Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser              
  1               5                  10            


<210> 67
<211> 11
<212> PRT
<213> Homo sapiens

<400> 67
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                      
  1               5                  10    


<210> 68
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<221> source
<223> /note="Description of Artificial Sequence: 
      Synthetic peptide"

<400> 68
Ser Phe Leu Leu Arg Asn                                          
  1               5    


<210> 69
<211> 20
<212> PRT
<213> Homo sapiens

<400> 69
Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val  
  1               5                  10                  15    

Thr Val Ser Ser                                                  
             20


<210> 70
<211> 12
<212> PRT
<213> Homo sapiens

<400> 70
Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys                  
  1               5                  10        


