                              Sequence Listing

<110> Genentech, Inc.
      Chen, Yvonne 
      Dennis, Mark 
      Dornan, David 
      Elkins, Kristi
      Junutula, Jagath Reddy
      Polson, Andrew
      Zheng, Bing 

<120> ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE

<130> P5111R1 WO


<150> US 60/950,052
<151> 2007-07-16

<150> US 61/025,137
<151> 2008-01-31

<150> US 61/032,790
<151> 2008-02-29

<150> US 61/054,709
<151> 2008-05-20

<160> 310

<210> 1
<211> 1270
<212> DNA
<213> Homo sapiens

<400> 1
 caggggacag gctgcagccg gtgcagttac acgttttcct ccaaggagcc 50

 tcggacgttg tcacgggttt ggggtcgggg acagagcagt gaccatggcc 100

 aggctggcgt tgtctcctgt gcccagccac tggatggtgg cgttgctgct 150

 gctgctctca gctgagccag taccagcagc cagatcggag gaccggtacc 200

 ggaatcccaa aggtagtgct tgttcgcgga tctggcagag cccacgtttc 250

 atagccagga aacggggctt cacggtgaaa atgcactgct acatgaacag 300

 cgcctccggc aatgtgagct ggctctggaa gcaggagatg gacgagaatc 350

 cccagcagct gaagctggaa aagggccgca tggaagagtc ccagaacgaa 400

 tctctcgcca ccctcaccat ccaaggcatc cggtttgagg acaatggcat 450

 ctacttctgt cagcagaagt gcaacaacac ctcggaggtc taccagggct 500

 gcggcacaga gctgcgagtc atgggattca gcaccttggc acagctgaag 550

 cagaggaaca cgctgaagga tggtatcatc atgatccaga cgctgctgat 600

 catcctcttc atcatcgtgc ctatcttcct gctgctggac aaggatgaca 650

 gcaaggctgg catggaggaa gatcacacct acgagggcct ggacattgac 700

 cagacagcca cctatgagga catagtgacg ctgcggacag gggaagtgaa 750

 gtggtctgta ggtgagcacc caggccagga gtgagagcca ggtcgcccca 800

 tgacctgggt gcaggctccc tggcctcagt gactgcttcg gagctgcctg 850

 gctcatggcc caaccccttt cctggacccc ccagctggcc tctgaagctg 900

 gcccaccaga gctgccattt gtctccagcc cctggtcccc agctcttgcc 950

 aaagggcctg gagtagaagg acaacagggc agcaacttgg agggagttct 1000

 ctggggatgg acgggaccca gccttctggg ggtgctatga ggtgatccgt 1050

 ccccacacat gggatggggg aggcagagac tggtccagag cccgcaaatg 1100

 gactcggagc cgagggcctc ccagcagagc ttgggaaggg ccatggaccc 1150

 aactgggccc cagaagagcc acaggaacat cattcctctc ccgcaaccac 1200

 tcccacccca gggaggccct ggcctccagt gccttccccc gtggaataaa 1250

 cggtgtgtcc tgagaaacca 1270

<210> 2
<211> 229
<212> PRT
<213> Homo sapiens

<400> 2
 Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val
   1               5                  10                  15

 Ala Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg
                  20                  25                  30

 Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg
                  35                  40                  45

 Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr
                  50                  55                  60

 Val Lys Met His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser
                  65                  70                  75

 Trp Leu Trp Lys Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys
                  80                  85                  90

 Leu Glu Lys Gly Arg Met Glu Glu Ser Gln Asn Glu Ser Leu Ala
                  95                 100                 105

 Thr Leu Thr Ile Gln Gly Ile Arg Phe Glu Asp Asn Gly Ile Tyr
                 110                 115                 120

 Phe Cys Gln Gln Lys Cys Asn Asn Thr Ser Glu Val Tyr Gln Gly
                 125                 130                 135

 Cys Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu Ala Gln
                 140                 145                 150

 Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln
                 155                 160                 165

 Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu
                 170                 175                 180

 Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr
                 185                 190                 195

 Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile
                 200                 205                 210

 Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His
                 215                 220                 225

 Pro Gly Gln Glu
                

<210> 3
<211> 929
<212> DNA
<213> Artificial sequence

<220>
<223> Light Chain of Chimeric Antibody (chMA79b)

<400> 3
 cactcccagc tccaactgca cctcggttct atcgattgaa ttccaccatg 50

 ggatggtcat gtatcatcct ttttctagta gcaactgcaa ctggagtaca 100

 ttcagatatc gtgctgaccc aatctccagc ttctttggct gtgtctctgg 150

 ggcagagggc caccatctcc tgcaaggcca gccaaagtgt tgattatgat 200

 ggtgatagtt ttttgaactg gtaccaacag aaaccaggac agccacccaa 250

 actcttcatc tatgctgcat ccaatctaga atctgggatc ccagccaggt 300

 ttagtggcag tgggtctggg acagacttca ccctcaacat ccatcctgtg 350

 gaggaggagg atgctgcaac ctattactgt cagcaaagta atgaggatcc 400

 gctcacgttc ggggcaggca ccgagctgga actcaaacgg accgtggctg 450

 caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga 500

 actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa 550

 agtacagtgg aaggtggata acgccctcca atcgggtaac tcccaggaga 600

 gtgtcacaga gcaggacagc aaggacagca cctacagcct cagcagcacc 650

 ctgacgctga gcaaagcaga ctacgagaaa cacaaagtct acgcctgcga 700

 agtcacccat cagggcctga gctcgcccgt cacaaagagc ttcaacaggg 750

 gagagtgtta agcttggccg ccatggccca acttgtttat tgcagcttat 800

 aatggttaca aataaagcaa tagcatcaca aatttcacaa ataaagcatt 850

 tttttcactg cattctagtt gtggtttgtc caaactcatc aatgtatctt 900

 atcatgtctg gatcgggaat  taattcggc 929

<210> 4
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light Chain of Chimeric Antibody (chMA79b)

<400> 4
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly
                  95                 100                 105

 Thr Glu Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 5
<211> 1469
<212> DNA
<213> Artificial sequence

<220>
<223> Heavy Chain of Chimeric Antibody (chMA79b)

<400> 5
 tcggttctat cgattgaatt ccaccatggg atggtcatgt atcatccttt 50

 ttctagtagc aactgcaact ggagtacatt cagaagttca gctgcagcag 100

 tctggggctg aactgatgaa gcctggggcc tcagtgaaga tatcctgcaa 150

 ggctactggc tacacattca gtagttactg gatagagtgg gtaaagcaga 200

 ggcctggaca tggccttgag tggattggag agattttacc tggaggtggt 250

 gatactaact acaatgagat tttcaagggc aaggccacat tcactgcaga 300

 tacatcctcc aacacagcct acatgcaact cagcagcctg acatctgagg 350

 actctgccgt ctattactgt acaagacgag taccggttta ctttgactac 400

 tggggccaag gaacctcagt caccgtctcc tcagcctcca ccaagggccc 450

 atcggtcttc cccctggcac cctcctccaa gagcacctct gggggcacag 500

 cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 550

 tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt 600

 cctacagtcc tcaggactct actccctcag cagcgtggtg actgtgccct 650

 ctagcagctt gggcacccag acctacatct gcaacgtgaa tcacaagccc 700

 agcaacacca aggtggacaa gaaagttgag cccaaatctt gtgacaaaac 750

 tcacacatgc ccaccgtgcc cagcacctga actcctgggg ggaccgtcag 800

 tcttcctctt ccccccaaaa cccaaggaca ccctcatgat ctcccggacc 850

 cctgaggtca catgcgtggt ggtggacgtg agccacgaag accctgaggt 900

 caagttcaac tggtacgtgg acggcgtgga ggtgcataat gccaagacaa 950

 agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc 1000

 accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt 1050

 ctccaacaaa gccctcccag cccccatcga gaaaaccatc tccaaagcca 1100

 aagggcagcc ccgagaacca caggtgtaca ccctgccccc atcccgggaa 1150

 gagatgacca agaaccaggt cagcctgacc tgcctggtca aaggcttcta 1200

 tcccagcgac atcgccgtgg agtgggagag caatgggcag ccggagaaca 1250

 actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc 1300

 tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt 1350

 ctcatgctcc gtgatgcatg aggctctgca caaccactac acgcagaaga 1400

 gcctctccct gtctccgggt aaatgagtgc gacggcccta gagtcgacct 1450

 gcagaagctt  ggccgccat 1469

<210> 6
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy Chain of Chimeric Antibody (chMA79b)

<400> 6
 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser
                  65                  70                  75

 Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 7
<211> 231
<212> PRT
<213> Macaca fascicularis

<400> 7
 Met Ala Arg Leu Ala Leu Ser Pro Val Ser Ser His Trp Leu Val
   1               5                  10                  15

 Ala Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala
                  20                  25                  30

 Lys Ser Glu Asp Leu Tyr Pro Asn Pro Lys Gly Ser Ala Cys Ser
                  35                  40                  45

 Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe
                  50                  55                  60

 Thr Val Lys Met His Cys Tyr Val Thr Asn Ser Thr Phe Ser Ile
                  65                  70                  75

 Val Ser Trp Leu Arg Lys Arg Glu Thr Asp Lys Glu Pro Gln Gln
                  80                  85                  90

 Val Asn Leu Glu Gln Gly His Met His Gln Thr Gln Asn Ser Ser
                  95                 100                 105

 Val Thr Thr Leu Ile Ile Gln Asp Ile Arg Phe Glu Asp Asn Gly
                 110                 115                 120

 Ile Tyr Phe Cys Gln Gln Glu Cys Ser Lys Thr Ser Glu Val Tyr
                 125                 130                 135

 Arg Gly Cys Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu
                 140                 145                 150

 Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met
                 155                 160                 165

 Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe
                 170                 175                 180

 Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Ala Asp
                 185                 190                 195

 His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
                 200                 205                 210

 Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly
                 215                 220                 225

 Glu His Pro Gly Gln Glu
                 230    

<210> 8
<211> 228
<212> PRT
<213> Mus musculus

<400> 8
 Met Ala Thr Leu Val Leu Ser Ser Met Pro Cys His Trp Leu Leu
   1               5                  10                  15

 Phe Leu Leu Leu Leu Phe Ser Gly Glu Pro Val Pro Ala Met Thr
                  20                  25                  30

 Ser Ser Asp Leu Pro Leu Asn Phe Gln Gly Ser Pro Cys Ser Gln
                  35                  40                  45

 Ile Trp Gln His Pro Arg Phe Ala Ala Lys Lys Arg Ser Ser Met
                  50                  55                  60

 Val Lys Phe His Cys Tyr Thr Asn His Ser Gly Ala Leu Thr Trp
                  65                  70                  75

 Phe Arg Lys Arg Gly Ser Gln Gln Pro Gln Glu Leu Val Ser Glu
                  80                  85                  90

 Glu Gly Arg Ile Val Gln Thr Gln Asn Gly Ser Val Tyr Thr Leu
                  95                 100                 105

 Thr Ile Gln Asn Ile Gln Tyr Glu Asp Asn Gly Ile Tyr Phe Cys
                 110                 115                 120

 Lys Gln Lys Cys Asp Ser Ala Asn His Asn Val Thr Asp Ser Cys
                 125                 130                 135

 Gly Thr Glu Leu Leu Val Leu Gly Phe Ser Thr Leu Asp Gln Leu
                 140                 145                 150

 Lys Arg Arg Asn Thr Leu Lys Asp Gly Ile Ile Leu Ile Gln Thr
                 155                 160                 165

 Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu
                 170                 175                 180

 Asp Lys Asp Asp Gly Lys Ala Gly Met Glu Glu Asp His Thr Tyr
                 185                 190                 195

 Glu Gly Leu Asn Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val
                 200                 205                 210

 Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His Pro
                 215                 220                 225

 Gly Gln Glu
            

<210> 9
<211> 108
<212> PRT
<213> Homo sapiens

<400> 9
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                  20                  25                  30

 Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Tyr Asn Ser Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 10
<211> 111
<212> PRT
<213> Artificial sequence

<220>
<223> Variable domain of Light Chain of Chimeric Antibody (chMA79b)

<400> 10
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Lys Pro Gly Gln
                  35                  40                  45

 Pro Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser Gly
                  50                  55                  60

 Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr
                  65                  70                  75

 Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr Tyr
                  80                  85                  90

 Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly Thr
                  95                 100                 105

 Glu Leu Glu Leu Lys Arg
                 110    

<210> 11
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of LIght Chain of Humanized Antibody Graft (huMA79b graft)

<400> 11
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 12
<211> 11
<212> PRT
<213> Homo sapiens

<400> 12
 Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys
                   5                  10    

<210> 13
<211> 113
<212> PRT
<213> Homo sapiens

<400> 13
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Phe Asp Tyr Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser
                 110            

<210> 14
<211> 117
<212> PRT
<213> Artificial Sequence

<220>
<223> Variable domain of Heavy Chain of Chimeric Antibody (chMA79b)

<400> 14
 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser
                  65                  70                  75

 Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser
                 110                 115        

<210> 15
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of Heavy Chain of Humanized Antibody Graft (huMA79b graft)

<400> 15
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 16
<211> 16
<212> PRT
<213> Homo sapiens

<400> 16
 Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys
   1               5                  10                  15

 Lys
    

<210> 17
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 17
 Lys Ala Ser Lys Ser Val Asp Tyr Asp Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 18
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 18
 Ala Ala Ser Asn Arg Glu Ser
                   5        

<210> 19
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 19
 Ala Ala Ser Asn Leu Lys Ser
                   5        

<210> 20
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 20
 Gln Gln Ser Asn Ser Asp Pro Leu Thr
                   5                

<210> 21
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 21
 Gln Gln Ser Asn Lys Asp Pro Leu Thr
                   5                

<210> 22
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 22
 Ala Ala Arg Lys Leu Gly Arg
                   5        

<210> 23
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 23
 Ala Ala Ser Arg Leu Glu Ser
                   5        

<210> 24
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 24
 Ala Ala Arg Lys Leu Gly Asn
                   5        

<210> 25
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 25
 Ala Ala Arg Lys Leu Lys Arg
                   5        

<210> 26
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 26
 Ala Ala Arg Tyr Leu Lys Arg
                   5        

<210> 27
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 27
 Ala Ala Arg Lys Leu Lys Ser
                   5        

<210> 28
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 28
 Ala Ala Arg Lys Leu Ala Ser
                   5        

<210> 29
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 29
 Ala Ala Gly Ile Leu Ala Arg
                   5        

<210> 30
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 30
 Ala Ala Arg Lys Leu Arg Ser
                   5        

<210> 31
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 31
 Ala Ala Arg Lys Leu Gly Ser
                   5        

<210> 32
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 32
 Ala Ala Arg His Leu Lys Arg
                   5        

<210> 33
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 33
 Ala Ser Arg Tyr Leu Ser Arg
                   5        

<210> 34
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 34
 Ala Gly Ser Lys Leu Leu Arg
                   5        

<210> 35
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 35
 Ala Ala Ser Asn Arg Lys Ser
                   5        

<210> 36
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 36
 Ala Ala Ser Lys Leu Gly Ser
                   5        

<210> 37
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 37
 Ala Ala Arg Tyr Leu Arg Arg
                   5        

<210> 38
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 38
 Ala Ala Arg Arg Leu Arg Thr
                   5        

<210> 39
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 39
 Ala Ala Arg Arg Leu Gly Arg
                   5        

<210> 40
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 40
 Ala Ala Arg Gln Arg Lys Arg
                   5        

<210> 41
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 41
 Ala Ala Arg Lys Leu Leu Arg
                   5        

<210> 42
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 42
 Ala Ala Arg Lys Leu Lys Asn
                   5        

<210> 43
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 43
 Ala Ala Arg Lys Leu Gly Thr
                   5        

<210> 44
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 44
 Ala Ala Arg Lys Leu Gly Gly
                   5        

<210> 45
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 45
 Ala Ala Arg Lys Leu Ala Arg
                   5        

<210> 46
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 46
 Gln Gln Ser Asn Ala Asp Pro Leu Thr
                   5                

<210> 47
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 47
 Gln Gln Ser Asn Gln Asp Pro Leu Thr
                   5                

<210> 48
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 48
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 49
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 49
 Gln Gln Ser Asn Asp Asp Pro Leu Thr
                   5                

<210> 50
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 50
 Gln Gln Ser Asn Leu Asp Pro Leu Thr
                   5                

<210> 51
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 51
 Asn Asn Ser Asn Gly Asp Pro Leu Asn
                   5                

<210> 52
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 52
 Gln Pro Asp Asn Glu Ala Pro Arg Thr
                   5                

<210> 53
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 53
 Asp Gln Arg Asn Ala Asp Pro Leu Thr
                   5                

<210> 54
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 54
 Gly Tyr Pro Phe Thr Arg Tyr Trp Ile Ser
                   5                  10

<210> 55
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 55
 Gly Tyr Pro Phe Arg Ser Tyr Trp Ile Gln
                   5                  10

<210> 56
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 56
 Gly Tyr Pro Phe Thr Ser Tyr Trp Ile Asn
                   5                  10

<210> 57
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 57
 Gly Tyr Pro Phe Thr Arg Tyr Trp Ile Asn
                   5                  10

<210> 58
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 58
 Gly Tyr Thr Phe Asn Arg Tyr Trp Ile Asn
                   5                  10

<210> 59
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 59
 Gly Tyr Ser Phe Lys Ser Tyr Trp Ile Glu
                   5                  10

<210> 60
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 60
 Pro Tyr Ser Leu Cys Thr Tyr Phe Ile Asp
                   5                  10

<210> 61
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 61
 Gly Tyr Tyr Phe Thr Ser Tyr Trp Ile Glu
                   5                  10

<210> 62
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 62
 Gly Tyr Pro Phe Gly Arg Tyr Trp Val Asn
                   5                  10

<210> 63
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 63
 Gly Tyr Thr Phe Lys Lys Tyr Trp Ile Glu
                   5                  10

<210> 64
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 64
 Gly Tyr Pro Phe Thr Ser Tyr Trp Ile Gln
                   5                  10

<210> 65
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 65
 Gly Tyr Pro Phe Arg Arg Tyr Trp Ile Glu
                   5                  10

<210> 66
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 66
 Gly Tyr Pro Val Gly Arg Tyr Trp Ile Ser
                   5                  10

<210> 67
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 67
 Gly Tyr Pro Phe Asn Arg Tyr Trp Ile Asn
                   5                  10

<210> 68
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 68
 Gly Tyr Gly Phe Thr Ser Tyr Trp Ile Ser
                   5                  10

<210> 69
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 69
 Gly Tyr Thr Phe Thr Ser Tyr Trp Leu Ser
                   5                  10

<210> 70
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 70
 Gly Tyr Thr Phe Thr Ser Tyr Trp Ile Glu
                   5                  10

<210> 71
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 71
 Gly Tyr Thr Phe Ser Gly Tyr Trp Ile Asn
                   5                  10

<210> 72
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 72
 Gly Tyr Thr Phe Arg Arg Tyr Trp Ile Asn
                   5                  10

<210> 73
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 73
 Gly Tyr Ser Phe Arg Ser Tyr Trp Ile Asn
                   5                  10

<210> 74
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 74
 Gly Tyr Ser Phe Arg Arg Tyr Trp Ile Asn
                   5                  10

<210> 75
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 75
 Gly Tyr Ser Phe Arg Arg Tyr Trp Ile Glu
                   5                  10

<210> 76
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 76
 Gly Tyr Ser Phe Pro Ser Tyr Trp Leu Gln
                   5                  10

<210> 77
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 77
 Gly Tyr Pro Phe Thr Arg Tyr Trp Ile Glu
                   5                  10

<210> 78
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 78
 Gly Tyr Pro Phe Ser Gly Tyr Trp Ile Glu
                   5                  10

<210> 79
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 79
 Gly Tyr Pro Phe Arg Ser Tyr Trp Ile Ser
                   5                  10

<210> 80
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 80
 Gly Tyr Pro Phe Arg Ser Tyr Trp Ile Asn
                   5                  10

<210> 81
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 81
 Gly Tyr Pro Phe Arg Gly Tyr Trp Ile Glu
                   5                  10

<210> 82
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 82
 Gly Tyr Pro Phe Asn Arg Tyr Trp Ile Glu
                   5                  10

<210> 83
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 83
 Gly Tyr Pro Phe Asn Gly Tyr Trp Ile Asn
                   5                  10

<210> 84
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 84
 Gly Tyr Asn Val Ser Ser Tyr Trp Leu Ser
                   5                  10

<210> 85
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 85
 Gly Phe Pro Phe Thr Ser Tyr Trp Ile Ser
                   5                  10

<210> 86
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 86
 Gly Phe Pro Phe Asn Arg Tyr Trp Ile Asn
                   5                  10

<210> 87
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 87
 Cys Thr Arg Arg Val Pro Ile Tyr Leu Asp
                   5                  10

<210> 88
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 88
 Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                   5                  10

<210> 89
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 89
 Cys Thr Arg Arg Val Pro Val Lys Leu Asp
                   5                  10

<210> 90
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 90
 Cys Thr Arg Arg Val Pro Val Tyr Leu Asp
                   5                  10

<210> 91
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 91
 Cys Thr Arg Arg Val Pro Ile Tyr Phe Asp
                   5                  10

<210> 92
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 92
 Cys Thr Arg Arg Val Pro Phe Cys Leu Asp
                   5                  10

<210> 93
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 93
 Cys Thr Arg Arg Val Pro Val Tyr Leu Asp
                   5                  10

<210> 94
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 94
 Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                   5                  10

<210> 95
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 95
 Cys Thr Arg Arg Val Pro Ile Lys Leu Asp
                   5                  10

<210> 96
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 96
 Cys Thr Arg Arg Val Pro Ile Arg Phe Asp
                   5                  10

<210> 97
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 97
 Cys Thr Arg Arg Val Pro Ile Tyr Phe Asp
                   5                  10

<210> 98
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 98
 Cys Thr Arg Arg Val Pro Val Tyr Phe Ser
                   5                  10

<210> 99
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 99
 Cys Thr Arg Arg Val Pro Val Val Leu Asp
                   5                  10

<210> 100
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 100
 Cys Thr Arg Arg Val Pro Val Arg Leu Asp
                   5                  10

<210> 101
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 101
 Cys Thr Arg Arg Val Pro Val Arg Phe Asp
                   5                  10

<210> 102
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 102
 Cys Thr Arg Arg Val Pro Val Phe Leu Asp
                   5                  10

<210> 103
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 103
 Cys Thr Arg Arg Val Pro Ile Tyr Leu Asp
                   5                  10

<210> 104
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 104
 Cys Thr Arg Arg Val Pro Ile Tyr Phe Asp
                   5                  10

<210> 105
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 105
 Cys Thr Arg Arg Arg Pro Val Cys Leu Asp
                   5                  10

<210> 106
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant

<400> 106
 Cys Thr Arg Arg Ile Pro Val Tyr Phe Asp
                   5                  10

<210> 107
<211> 10
<212> PRT
<213> Mus musculus

<400> 107
 Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                   5                  10

<210> 108
<211> 87
<212> PRT
<213> Homo sapiens

<400> 108
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg
                  35                  40                  45

 Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
                  50                  55                  60

 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 109
<211> 81
<212> PRT
<213> Homo sapiens

<400> 109
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 110
<211> 80
<212> PRT
<213> Homo sapiens

<400> 110
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 111
<211> 79
<212> PRT
<213> Homo sapiens

<400> 111
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 112
<211> 86
<212> PRT
<213> Homo sapiens

<400> 112
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser
                  20                  25                  30

 Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Arg Val
                  35                  40                  45

 Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu
                  50                  55                  60

 Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg
                  65                  70                  75

 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85    

<210> 113
<211> 81
<212> PRT
<213> Homo sapiens

<400> 113
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 114
<211> 80
<212> PRT
<213> Homo sapiens

<400> 114
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 115
<211> 79
<212> PRT
<213> Homo sapiens

<400> 115
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 116
<211> 87
<212> PRT
<213> Homo sapiens

<400> 116
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 117
<211> 81
<212> PRT
<213> Homo sapiens

<400> 117
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 118
<211> 80
<212> PRT
<213> Homo sapiens

<400> 118
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 119
<211> 79
<212> PRT
<213> Homo sapiens

<400> 119
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 120
<211> 87
<212> PRT
<213> Homo sapiens

<400> 120
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 121
<211> 81
<212> PRT
<213> Homo sapiens

<400> 121
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 122
<211> 80
<212> PRT
<213> Homo sapiens

<400> 122
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ser Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 123
<211> 86
<212> PRT
<213> Homo sapiens

<400> 123
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Cys Ala Arg
                  65                  70                  75

 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85    

<210> 124
<211> 81
<212> PRT
<213> Homo sapiens

<400> 124
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 125
<211> 80
<212> PRT
<213> Homo sapiens

<400> 125
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 126
<211> 79
<212> PRT
<213> Homo sapiens

<400> 126
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 127
<211> 80
<212> PRT
<213> Homo sapiens

<400> 127
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Lys Ala Pro Lys Leu Leu Ile Tyr Gly Val Pro Ser Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  50                  55                  60

 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 128
<211> 80
<212> PRT
<213> Homo sapiens

<400> 128
 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro
   1               5                  10                  15

 Gly Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly
                  20                  25                  30

 Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val
                  50                  55                  60

 Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 129
<211> 80
<212> PRT
<213> Homo sapiens

<400> 129
 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro
   1               5                  10                  15

 Gly Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
                  50                  55                  60

 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 130
<211> 80
<212> PRT
<213> Homo sapiens

<400> 130
 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Glu Arg Ala Thr Ile Asn Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Pro Pro Lys Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  50                  55                  60

 Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 131
<211> 15
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR1-LC of huMA79b graft

<400> 131
 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 132
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR2-LC of huMA79b graft

<400> 132
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 133
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR3-LC of huMA79b graft

<400> 133
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 134
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR1-HC of huMA79b graft

<400> 134
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 135
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR2-HC of huMA79b graft

<400> 135
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 136
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR3-HC of huMA79b graft

<400> 136
 Thr Arg Arg Val Pro Val Tyr Phe Asp Tyr
                   5                  10

<210> 137
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b. V28)

<400> 137
 Lys Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 138
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b. V28)

<400> 138
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10

<210> 139
<211> 23
<212> PRT
<213> Homo sapiens

<400> 139
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 140
<211> 15
<212> PRT
<213> Homo sapiens

<400> 140
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 141
<211> 32
<212> PRT
<213> Homo sapiens

<400> 141
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 142
<211> 11
<212> PRT
<213> Homo sapiens

<400> 142
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 143
<211> 25
<212> PRT
<213> Homo sapiens

<400> 143
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 144
<211> 13
<212> PRT
<213> Homo sapiens

<400> 144
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 145
<211> 30
<212> PRT
<213> Homo sapiens

<400> 145
 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 146
<211> 11
<212> PRT
<213> Homo sapiens

<400> 146
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 147
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> FR3-HC Composite of Humanized Antibody Varients

<220>
<221> Xaa
<222> 6
<223> Xaa is A or R

<220>
<221> Xaa
<222> 8
<223> Xaa is T or N

<220>
<221> Xaa
<222> 13
<223> Xaa is A or L

<400> 147
 Arg Phe Thr Ile Ser Xaa Asp Xaa Ser Lys Asn Thr Xaa Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 148
<211> 31
<212> PRT
<213> Homo sapiens

<400> 148
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala
    

<210> 149
<211> 32
<212> PRT
<213> Homo sapiens

<400> 149
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala Arg
        

<210> 150
<211> 31
<212> PRT
<213> Homo sapiens

<400> 150
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ser
    

<210> 151
<211> 32
<212> PRT
<213> Homo sapiens

<400> 151
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ser Arg
        

<210> 152
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 152
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 153
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC Humanized Antibody variant huMA79b.v17)

<400> 153
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 154
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody variant (huMA79b.v17)

<400> 154
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 155
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 155
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 156
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 156
 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 157
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 157
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 158
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v17)

<400> 158
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 159
<211> 106
<212> PRT
<213> Artificial sequence

<220>
<223> CL1-LC ofHumanized Antibody Variant (huMA79b.v17)

<400> 159
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 160
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 160
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 161
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 161
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 162
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 162
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 163
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 163
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 164
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 164
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 165
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 165
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 166
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-H3 of Humanized Antibody Variant (huMA79b.v17)

<400> 166
 Thr Arg Arg Val Pro Val Tyr Phe Asp Tyr
                   5                  10

<210> 167
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Varient (huMA79b.v17)

<400> 167
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 168
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.v17)

<400> 168
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 169
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC-HC Variety Domain of Humanized Antibody Varient(huMA79b.v17)

<400> 169
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 170
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody Variant (huMA79b.v17)

<400> 170
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 171
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 171
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 172
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 172
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 173
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 173
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 174
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 174
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 175
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 175
 Lys Ala Ser Gln Ser Val Asp Tyr Asp Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 176
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 176
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 177
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 177
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 178
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> CL1-LC of Humanized Antibody Variant (huMA79b.v18)

<400> 178
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 179
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 179
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 180
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 180
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 181
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 181
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 182
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 182
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 183
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 183
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 184
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 184
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 185
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 185
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10

<210> 186
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 186
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 187
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.v18)

<400> 187
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 188
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC-Variable Domain of Humanized Antibody Variant (huMA79b.v18)

<400> 188
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 189
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody Variant (huMA79b.v18)

<400> 189
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 190
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 190
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 191
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 191
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 192
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 192
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 193
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 193
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 194
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 194
 Lys Ala Ser Gln Ser Val Asp Tyr Glu Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 195
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 195
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 196
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 196
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 197
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> CL1-LC of Humanized Antibody Variant (huMA79b.v28)

<400> 197
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 198
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 198
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 199
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 199
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 200
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 200
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 201
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 201
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 202
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 202
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 203
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HLC of Humanized Antibody Variant (huMA79b.v28)

<400> 203
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 204
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 204
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10

<210> 205
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Variant (huMA79b.v28)

<400> 205
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 206
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.V28)

<400> 206
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 207
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC-variable domain of (huMA79b.v28)

<400> 207
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Glu Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 208
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody (huMA79b.v28)

<400> 208
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 209
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 209
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 210
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 210
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Phe Ile Tyr
   1               5                  10                  15

<210> 211
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 211
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 212
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 212
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 213
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 213
 Lys Ala Ser Gln Ser Val Asp Tyr Ser Gly Asp Ser Phe Leu Asn
   1               5                  10                  15

<210> 214
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 214
 Ala Ala Ser Asn Leu Glu Ser
                   5        

<210> 215
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 215
 Gln Gln Ser Asn Glu Asp Pro Leu Thr
                   5                

<210> 216
<211> 106
<212> PRT
<213> Artificial Sequence

<220>
<223> CL1-LC of Humanized Antibody Variant (huMA79b.v32)

<400> 216
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 217
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 217
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 218
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 218
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile
                   5                  10            

<210> 219
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 219
 Arg Ala Thr Phe Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 220
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 220
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 221
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 221
 Gly Tyr Thr Phe Ser Ser Tyr Trp Ile Glu
                   5                  10

<210> 222
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 222
 Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr Asn Glu Ile
   1               5                  10                  15

 Phe Lys Gly
            

<210> 223
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 223
 Thr Arg Arg Val Pro Ile Arg Leu Asp Tyr
                   5                  10

<210> 224
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 224
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 225
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc-HC of Humanized Antibody Variant (huMA79b.v32)

<400> 225
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 226
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> LC -Variable Domain of Humanized Antibody Variant (huMA79b.v32)

<400> 226
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Ser Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg
                 110        

<210> 227
<211> 117
<212> PRT
<213> Artificial sequence

<220>
<223> HC-Variable Domain of Humanized Antibody Variant (huMA79b.v32)

<400> 227
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                 110                 115        

<210> 228
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-huMA79b.v17-HC(All8C) Variant - HC

<400> 228
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Cys Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 229
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-huMA79b.v17-HC(All8C) Variant - LC

<400> 229
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 230
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-huMA79b.v18-HC(All8C) Variant - HC

<400> 230
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Cys Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 231
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-huMA79b.v18-HC(All8C) Variant - LC

<400> 231
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 232
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-huMA79b.v28-HC(All8C) Variant - HC

<400> 232
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Cys Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 233
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-huMA79b.v28-HC(All8C) Variant - LC

<400> 233
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Glu Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 234
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-chMA79b- LC(V205C)  Variant - HC

<400> 234
 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser
                  65                  70                  75

 Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 235
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-chMA79b- LC(V205C)  Variant - LC

<400> 235
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly
                  95                 100                 105

 Thr Glu Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Cys Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 236
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-chMA79b- HC(A118C)  Variant - HC

<400> 236
 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Lys Gln Arg Pro Gly His Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser
                  65                  70                  75

 Ser Asn Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Cys Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 237
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> ThioMAb-chMA79b- HC(A118C)  Variant - LC

<400> 237
 Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Asn Ile His Pro Val Glu Glu Glu Asp Ala Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Ala Gly
                  95                 100                 105

 Thr Glu Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 238
<211> 893
<212> DNA
<213> Macaca fascicularis

<400> 238
 tcatggtgat ggtgatgatg accggtacgc gtagaatcga gaccgaggag 50

 agggttaggg ataggcttac cttcgaaccg cgggccctct agactcgagc 100

 ggccgccact gtgctggata tctgcagaat tgcccttggg gacagagcag 150

 tgaccatggc caggctggcg ttgtctcctg tgtccagcca ctggctggtg 200

 gcgttgctgc tgctgctctc agcagctgag ccagtgccag cagccaaatc 250

 agaggacctg tacccgaatc ccaaaggtag tgcttgttct cggatctggc 300

 agagcccacg tttcatagcc aggaaacggg gcttcacggt gaaaatgcac 350

 tgctacgtga ccaacagcac cttcagcatc gtgagctggc tccggaagcg 400

 ggagacggac aaggagcccc aacaggtgaa cctggagcag ggccacatgc 450

 atcagaccca aaacagctct gtcaccaccc tcatcatcca agacatccgg 500

 tttgaggaca acggcatcta cttctgtcag caggagtgca gcaagacctc 550

 ggaggtctac cggggctgcg gcacggagct gcgagtcatg gggttcagca 600

 ccttggcaca gctgaagcag aggaacacgc tgaaggatgg catcatcatg 650

 atccagacgc tgctgatcat cctcttcatc atcgtgccca tcttcctgct 700

 gctggacaag gatgacagca aggccggcat ggaggaagat cacacctacg 750

 agggcctgga cattgaccag acggccacct acgaggacat agtgacgctg 800

 cggacagggg aagtgaagtg gtctgtgggt gagcacccag gtcaggagtg 850

 agagccagga cctccccacg gcctgggtgc aggctcccca  gcc 893

<210> 239
<211> 231
<212> PRT
<213> Macaca fascicularis

<400> 239
 Met Ala Arg Leu Ala Leu Ser Pro Val Ser Ser His Trp Leu Val
   1               5                  10                  15

 Ala Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala
                  20                  25                  30

 Lys Ser Glu Asp Leu Tyr Pro Asn Pro Lys Gly Ser Ala Cys Ser
                  35                  40                  45

 Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe
                  50                  55                  60

 Thr Val Lys Met His Cys Tyr Val Thr Asn Ser Thr Phe Ser Ile
                  65                  70                  75

 Val Ser Trp Leu Arg Lys Arg Glu Thr Asp Lys Glu Pro Gln Gln
                  80                  85                  90

 Val Asn Leu Glu Gln Gly His Met His Gln Thr Gln Asn Ser Ser
                  95                 100                 105

 Val Thr Thr Leu Ile Ile Gln Asp Ile Arg Phe Glu Asp Asn Gly
                 110                 115                 120

 Ile Tyr Phe Cys Gln Gln Glu Cys Ser Lys Thr Ser Glu Val Tyr
                 125                 130                 135

 Arg Gly Cys Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu
                 140                 145                 150

 Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met
                 155                 160                 165

 Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe
                 170                 175                 180

 Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp
                 185                 190                 195

 His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
                 200                 205                 210

 Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly
                 215                 220                 225

 Glu His Pro Gly Gln Glu
                 230    

<210> 240
<211> 800
<212> DNA
<213> Artificial sequence

<220>
<223> Chimeric anti-cyno CD79b (ch10D10)- LC

<400> 240
 acctcggttc tatcgattga attccaccat gggatggtca tgtatcatcc 50

 tttttctagt agcaactgca actggagtac attcagatat cgtgctgacc 100

 caatctccac cctctttggc tgtgtctcta gggcagaggg ccaccatatc 150

 ctgcagagcc agtgaaagtg ttgatagtta tggcaaaact tttatgcact 200

 ggcaccagca gaaaccagga cagccaccca aactcctcat ctatcgtgta 250

 tccaacctag aatctgggat ccctgccagg ttcagtggca gtgggtcaag 300

 gacagacttc accctcacca ttaatcctgt ggaggctgat gatgttgcaa 350

 cctattactg tcagcaaagt aatgaggatc cgttcacgtt cggtggaggc 400

 accaagctgg aaatcaaacg gaccgtggct gcaccatctg tcttcatctt 450

 cccgccatct gatgagcagt tgaaatctgg aactgcctct gttgtgtgcc 500

 tgctgaataa cttctatccc agagaggcca aagtacagtg gaaggtggat 550

 aacgccctcc aatcgggtaa ctcccaggag agtgtcacag agcaggacag 600

 caaggacagc acctacagcc tcagcagcac cctgacgctg agcaaagcag 650

 actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg 700

 agctcgcccg tcacaaagag cttcaacagg ggagagtgtt aagcttggcc 750

 gccatggccc aacttgttta ttgcagctta taatggttac aaataaagca 800

<210> 241
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Chimeric anti-cyno CD79b (ch10D10)- LC

<400> 241
 Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp
                  20                  25                  30

 Ser Tyr Gly Lys Thr Phe Met His Trp His Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Phe Thr Phe Gly Gly Gly
                  95                 100                 105

 Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 242
<211> 1500
<212> DNA
<213> Artificial sequence

<220>
<223> Chimeric anti-cyno CD79b (ch10D10)- LC

<400> 242
 cacctcggtt ctatcgattg aattccacca tgggatggtc atgtatcatc 50

 ctttttctag tagcaactgc aactggagta cattcagaag ttcagctgca 100

 ggagtcggga cctggcctgg tgaaaccttc tcagtctctg tccctcacct 150

 gcactgtcac tggctactca atcaccagtg attatgcctg gaactggatc 200

 cggcagtttc caggaaacaa actggagtgg atgggcaaca tatggtacag 250

 tggtagcact acctacaacc catctctcaa aagtcgaatc tctatcactc 300

 gagacacatc caagaaccag ttcttcctgc agttgaattc tgtgacttct 350

 gaggacacag ccacatatta ctgttcaaga atggacttct ggggtcaagg 400

 caccactctc acagtctcct cagcctccac caagggccca tcggtcttcc 450

 ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 500

 tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc 550

 aggcgccctg accagcggcg tgcacacctt cccggctgtc ctacagtcct 600

 caggactcta ctccctcagc agcgtggtga ctgtgccctc tagcagcttg 650

 ggcacccaga cctacatctg caacgtgaat cacaagccca gcaacaccaa 700

 ggtggacaag aaagttgagc ccaaatcttg tgacaaaact cacacatgcc 750

 caccgtgccc agcacctgaa ctcctggggg gaccgtcagt cttcctcttc 800

 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac 850

 atgcgtggtg gtggacgtga gccacgaaga ccctgaggtc aagttcaact 900

 ggtacgtgga cggcgtggag gtgcataatg ccaagacaaa gccgcgggag 950

 gagcagtaca acagcacgta ccgtgtggtc agcgtcctca ccgtcctgca 1000

 ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc tccaacaaag 1050

 ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1100

 cgagaaccac aggtgtacac cctgccccca tcccgggaag agatgaccaa 1150

 gaaccaggtc agcctgacct gcctggtcaa aggcttctat cccagcgaca 1200

 tcgccgtgga gtgggagagc aatgggcagc cggagaacaa ctacaagacc 1250

 acgcctcccg tgctggactc cgacggctcc ttcttcctct acagcaagct 1300

 caccgtggac aagagcaggt ggcagcaggg gaacgtcttc tcatgctccg 1350

 tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 1400

 tctccgggta aatgagtgcg acggccctag agtcgacctg cagaagcttg 1450

 gccgccatgg cccaacttgt ttattgcagc ttataatggt tacaaataaa 1500

<210> 243
<211> 441
<212> PRT
<213> Artificial sequence

<220>
<223> Chimeric anti-cyno CD79b (ch10D10)- LC

<400> 243
 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Gly Asn Ile Trp Tyr Ser Gly Ser Thr Thr Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ser Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ser Arg Met Asp Phe Trp Gly Gln Gly
                  95                 100                 105

 Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
                 110                 115                 120

 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
                 125                 130                 135

 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
                 140                 145                 150

 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                 155                 160                 165

 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
                 170                 175                 180

 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
                 185                 190                 195

 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
                 200                 205                 210

 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
                 215                 220                 225

 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                 230                 235                 240

 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                 245                 250                 255

 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
                 260                 265                 270

 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
                 275                 280                 285

 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
                 290                 295                 300

 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
                 305                 310                 315

 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                 320                 325                 330

 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
                 335                 340                 345

 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
                 350                 355                 360

 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
                 365                 370                 375

 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                 380                 385                 390

 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                 395                 400                 405

 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                 410                 415                 420

 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
                 425                 430                 435

 Leu Ser Leu Ser Pro Gly
                 440    

<210> 244
<211> 441
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-MAb-anti-cynoCD79b(ch10D10)-HC(A118C) Variant - HC

<400> 244
 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Gly Asn Ile Trp Tyr Ser Gly Ser Thr Thr Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ser Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ser Arg Met Asp Phe Trp Gly Gln Gly
                  95                 100                 105

 Thr Thr Leu Thr Val Ser Ser Cys Ser Thr Lys Gly Pro Ser Val
                 110                 115                 120

 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
                 125                 130                 135

 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
                 140                 145                 150

 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                 155                 160                 165

 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
                 170                 175                 180

 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
                 185                 190                 195

 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
                 200                 205                 210

 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
                 215                 220                 225

 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                 230                 235                 240

 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                 245                 250                 255

 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
                 260                 265                 270

 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
                 275                 280                 285

 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
                 290                 295                 300

 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
                 305                 310                 315

 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                 320                 325                 330

 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
                 335                 340                 345

 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
                 350                 355                 360

 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
                 365                 370                 375

 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                 380                 385                 390

 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                 395                 400                 405

 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                 410                 415                 420

 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
                 425                 430                 435

 Leu Ser Leu Ser Pro Gly
                 440    

<210> 245
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-MAb-anti-cynoCD79b(ch10D10)-HC(A118C) Variant - LC

<400> 245
 Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp
                  20                  25                  30

 Ser Tyr Gly Lys Thr Phe Met His Trp His Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Phe Thr Phe Gly Gly Gly
                  95                 100                 105

 Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 246
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin binding peptide

<400> 246
 Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gln Arg Leu Met Glu
   1               5                  10                  15

 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp Phe
                  20                  25                  30

<210> 247
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin binding peptide

<400> 247
 Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu
   1               5                  10                  15

 Trp Glu Asp Asp Phe
                  20

<210> 248
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin binding peptide

<400> 248
 Gln Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu
   1               5                  10                  15

 Trp Glu Asp Asp Phe
                  20

<210> 249
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin binding peptide

<400> 249
 Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
   1               5                  10                  15

 Glu Asp Asp
            

<210> 250
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin binding peptide

<400> 250
 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
                   5                  10    

<210> 251
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 251
 Glu Val Gln Leu Cys Glu Ser Gly Gly Gly
                   5                  10

<210> 252
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 252
 Leu Arg Leu Ser Cys Cys Ala Ser Gly Tyr Thr
                   5                  10    

<210> 253
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 253
 Met Asn Ser Leu Arg Cys Glu Asp Thr Ala Val
                   5                  10    

<210> 254
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 254
 Thr Leu Val Thr Val Cys Ser Ala Ser Thr Lys
                   5                  10    

<210> 255
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 255
 Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 256
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 256
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 257
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 257
 Trp Tyr Val Asp Gly Cys Glu Val His Asn Ala
                   5                  10    

<210> 258
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b HC-variant

<400> 258
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 259
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 259
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 260
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 260
 Glu Val Gln Leu Cys Gln Ser Gly Ala Glu
                   5                  10

<210> 261
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 261
 Val Lys Ile Ser Cys Cys Ala Thr Gly Tyr Thr
                   5                  10    

<210> 262
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 262
 Leu Ser Ser Leu Thr Cys Glu Asp Ser Ala Val
                   5                  10    

<210> 263
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 263
 Thr Ser Val Thr Val Cys Ser Ala Ser Thr Lys
                   5                  10    

<210> 264
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 264
 Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 265
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 265
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 266
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 266
 Trp Tyr Val Asp Gly Cys Glu Val His Asn Ala
                   5                  10    

<210> 267
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 267
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 268
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b HC-variant

<400> 268
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 269
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 269
 Glu Val Gln Leu Cys Glu Ser Gly Pro Gly
                   5                  10

<210> 270
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 270
 Leu Ser Leu Thr Cys Cys Val Thr Gly Tyr Ser
                   5                  10    

<210> 271
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 271
 Leu Asn Ser Val Thr Cys Glu Asp Thr Ala Thr
                   5                  10    

<210> 272
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 272
 Thr Thr Leu Thr Val Cys Ser Ala Ser Thr Lys
                   5                  10    

<210> 273
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 273
 Leu Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 274
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 274
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 275
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-cynoCD79b (ch10D10)-HC-variant

<400> 275
 Trp Tyr Val Asp Gly Cys Glu Val His Asn Ala
                   5                  10    

<210> 276
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 276
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 277
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 277
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 278
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 278
 Ser Leu Ser Ala Ser Cys Gly Asp Arg Val Thr
                   5                  10    

<210> 279
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 279
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 280
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 280
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 281
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 281
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 282
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 282
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 283
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 283
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 284
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-huMA79b LC-variant

<400> 284
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 285
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 285
 Ser Leu Ala Val Ser Cys Gly Gln Arg Ala Thr
                   5                  10    

<210> 286
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 286
 Glu Leu Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 287
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 287
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 288
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 288
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 289
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 289
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 290
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 290
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 291
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-chMA79b LC-variant

<400> 291
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 292
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 292
 Ser Leu Ala Val Ser Cys Gly Gln Arg Ala Thr
                   5                  10    

<210> 293
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 293
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 294
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 294
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 295
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 295
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 296
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 296
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 297
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 297
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 298
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-HC-variant

<400> 298
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 299
<211> 441
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b-LC(V205C) Variant - HC

<400> 299
 Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Gly Asn Ile Trp Tyr Ser Gly Ser Thr Thr Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ser Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ser Arg Met Asp Phe Trp Gly Gln Gly
                  95                 100                 105

 Thr Thr Leu Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val
                 110                 115                 120

 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala
                 125                 130                 135

 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
                 140                 145                 150

 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                 155                 160                 165

 Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val
                 170                 175                 180

 Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys
                 185                 190                 195

 Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val
                 200                 205                 210

 Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro
                 215                 220                 225

 Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
                 230                 235                 240

 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr
                 245                 250                 255

 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe
                 260                 265                 270

 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys
                 275                 280                 285

 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val
                 290                 295                 300

 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys
                 305                 310                 315

 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
                 320                 325                 330

 Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr
                 335                 340                 345

 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu
                 350                 355                 360

 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu
                 365                 370                 375

 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
                 380                 385                 390

 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                 395                 400                 405

 Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys
                 410                 415                 420

 Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser
                 425                 430                 435

 Leu Ser Leu Ser Pro Gly
                 440    

<210> 300
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-cynoCD79b(ch10D10)-LC(V205C) Variant - LC

<400> 300
 Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp
                  20                  25                  30

 Ser Tyr Gly Lys Thr Phe Met His Trp His Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Phe Thr Phe Gly Gly Gly
                  95                 100                 105

 Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Cys Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 301
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> anti-cynoCD79b (ch10D10) - variable of HC

<400> 301
 Glu Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr
                  20                  25                  30

 Ser Asp Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys
                  35                  40                  45

 Leu Glu Trp Met Gly Asn Ile Trp Tyr Ser Gly Ser Thr Thr Tyr
                  50                  55                  60

 Asn Pro Ser Leu Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser
                  65                  70                  75

 Lys Asn Gln Phe Phe Leu Gln Leu Asn Ser Val Thr Ser Glu Asp
                  80                  85                  90

 Thr Ala Thr Tyr Tyr Cys Ser Arg Met Asp Phe Trp Gly Gln Gly
                  95                 100                 105

 Thr Thr Leu Thr Val Ser Ser
                 110        

<210> 302
<211> 112
<212> PRT
<213> Artificial sequence

<220>
<223> anti-cynoCD79b (ch10D10) - variable  domain of LC

<400> 302
 Asp Ile Val Leu Thr Gln Ser Pro Pro Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp
                  20                  25                  30

 Ser Tyr Gly Lys Thr Phe Met His Trp His Gln Gln Lys Pro Gly
                  35                  40                  45

 Gln Pro Pro Lys Leu Leu Ile Tyr Arg Val Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Ile Pro Ala Arg Phe Ser Gly Ser Gly Ser Arg Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Asn Pro Val Glu Ala Asp Asp Val Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Phe Thr Phe Gly Gly Gly
                  95                 100                 105

 Thr Lys Leu Glu Ile Lys Arg
                 110        

<210> 303
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.17

<400> 303
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 304
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.17

<400> 304
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Val Tyr Phe Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 305
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.18

<400> 305
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Asp Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 306
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.18

<400> 306
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 307
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.28

<400> 307
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Glu Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 308
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.28

<400> 308
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

<210> 309
<211> 218
<212> PRT
<213> Artificial sequence

<220>
<223> Light chain of huMA79bv.32

<400> 309
 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser Val Asp
                  20                  25                  30

 Tyr Ser Gly Asp Ser Phe Leu Asn Trp Tyr Gln Gln Lys Pro Gly
                  35                  40                  45

 Lys Ala Pro Lys Leu Phe Ile Tyr Ala Ala Ser Asn Leu Glu Ser
                  50                  55                  60

 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
                  65                  70                  75

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  80                  85                  90

 Tyr Cys Gln Gln Ser Asn Glu Asp Pro Leu Thr Phe Gly Gln Gly
                  95                 100                 105

 Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe
                 110                 115                 120

 Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser
                 125                 130                 135

 Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val
                 140                 145                 150

 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
                 155                 160                 165

 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser
                 170                 175                 180

 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val
                 185                 190                 195

 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr
                 200                 205                 210

 Lys Ser Phe Asn Arg Gly Glu Cys
                 215            

<210> 310
<211> 446
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of huMA79bv.32

<400> 310
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Ser
                  20                  25                  30

 Ser Tyr Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Glu Ile Leu Pro Gly Gly Gly Asp Thr Asn Tyr
                  50                  55                  60

 Asn Glu Ile Phe Lys Gly Arg Ala Thr Phe Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Thr Arg Arg Val Pro Ile Arg Leu Asp
                  95                 100                 105

 Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr
                 110                 115                 120

 Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr
                 125                 130                 135

 Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe
                 140                 145                 150

 Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
                 155                 160                 165

 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr
                 170                 175                 180

 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr
                 185                 190                 195

 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys
                 200                 205                 210

 Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr
                 215                 220                 225

 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
                 230                 235                 240

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                 245                 250                 255

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                 260                 265                 270

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                 275                 280                 285

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                 290                 295                 300

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                 305                 310                 315

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                 320                 325                 330

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 335                 340                 345

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 350                 355                 360

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 365                 370                 375

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 380                 385                 390

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 395                 400                 405

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 410                 415                 420

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 425                 430                 435

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 440                 445    

