                              Sequence Listing

<110> GENENTECH, INC. et al.

<120> HUMANIZED ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE

<130> P5112R1 WO

<141> 2007-10-19

<150> US 60/950,088
<151> 2007-07-16

<160> 122

<210> 1
<211> 1270
<212> DNA
<213> Homo sapiens

<400> 1
 caggggacag gctgcagccg gtgcagttac acgttttcct ccaaggagcc 50

 tcggacgttg tcacgggttt ggggtcgggg acagagcagt gaccatggcc 100

 aggctggcgt tgtctcctgt gcccagccac tggatggtgg cgttgctgct 150

 gctgctctca gctgagccag taccagcagc cagatcggag gaccggtacc 200

 ggaatcccaa aggtagtgct tgttcgcgga tctggcagag cccacgtttc 250

 atagccagga aacggggctt cacggtgaaa atgcactgct acatgaacag 300

 cgcctccggc aatgtgagct ggctctggaa gcaggagatg gacgagaatc 350

 cccagcagct gaagctggaa aagggccgca tggaagagtc ccagaacgaa 400

 tctctcgcca ccctcaccat ccaaggcatc cggtttgagg acaatggcat 450

 ctacttctgt cagcagaagt gcaacaacac ctcggaggtc taccagggct 500

 gcggcacaga gctgcgagtc atgggattca gcaccttggc acagctgaag 550

 cagaggaaca cgctgaagga tggtatcatc atgatccaga cgctgctgat 600

 catcctcttc atcatcgtgc ctatcttcct gctgctggac aaggatgaca 650

 gcaaggctgg catggaggaa gatcacacct acgagggcct ggacattgac 700

 cagacagcca cctatgagga catagtgacg ctgcggacag gggaagtgaa 750

 gtggtctgta ggtgagcacc caggccagga gtgagagcca ggtcgcccca 800

 tgacctgggt gcaggctccc tggcctcagt gactgcttcg gagctgcctg 850

 gctcatggcc caaccccttt cctggacccc ccagctggcc tctgaagctg 900

 gcccaccaga gctgccattt gtctccagcc cctggtcccc agctcttgcc 950

 aaagggcctg gagtagaagg acaacagggc agcaacttgg agggagttct 1000

 ctggggatgg acgggaccca gccttctggg ggtgctatga ggtgatccgt 1050

 ccccacacat gggatggggg aggcagagac tggtccagag cccgcaaatg 1100

 gactcggagc cgagggcctc ccagcagagc ttgggaaggg ccatggaccc 1150

 aactgggccc cagaagagcc acaggaacat cattcctctc ccgcaaccac 1200

 tcccacccca gggaggccct ggcctccagt gccttccccc gtggaataaa 1250

 cggtgtgtcc tgagaaacca 1270

<210> 2
<211> 229
<212> PRT
<213> Homo sapiens

<400> 2
 Met Ala Arg Leu Ala Leu Ser Pro Val Pro Ser His Trp Met Val
   1               5                  10                  15

 Ala Leu Leu Leu Leu Leu Ser Ala Glu Pro Val Pro Ala Ala Arg
                  20                  25                  30

 Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys Ser Arg
                  35                  40                  45

 Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe Thr
                  50                  55                  60

 Val Lys Met His Cys Tyr Met Asn Ser Ala Ser Gly Asn Val Ser
                  65                  70                  75

 Trp Leu Trp Lys Gln Glu Met Asp Glu Asn Pro Gln Gln Leu Lys
                  80                  85                  90

 Leu Glu Lys Gly Arg Met Glu Glu Ser Gln Asn Glu Ser Leu Ala
                  95                 100                 105

 Thr Leu Thr Ile Gln Gly Ile Arg Phe Glu Asp Asn Gly Ile Tyr
                 110                 115                 120

 Phe Cys Gln Gln Lys Cys Asn Asn Thr Ser Glu Val Tyr Gln Gly
                 125                 130                 135

 Cys Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu Ala Gln
                 140                 145                 150

 Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met Ile Gln
                 155                 160                 165

 Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu
                 170                 175                 180

 Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Glu Asp His Thr
                 185                 190                 195

 Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile
                 200                 205                 210

 Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His
                 215                 220                 225

 Pro Gly Gln Glu
                

<210> 3
<211> 657
<212> DNA
<213> Artificial sequence

<220>
<223> Chimeric 2F2 Antibody - Light Chain

<400> 3
 gatatcgtga tgacccagac tccactcact ttgtcggtta ccattggaca 50

 accagcctcc atctcttgca agtcaagtca gagcctctta gatagtgatg 100

 gaaagacata tttgaattgg ttattacaga ggccaggcca gtctccagag 150

 cgcctaattt atctggtgtc taaactggat tctggagtcc ctgacaggtt 200

 cactggcagt ggatcaggga cagatttcac actgaaaatc agcagagtgg 250

 aggctgagga tttgggagtt tattgttgct ggcaaggtac acattttccg 300

 tacacgttcg gagggggtac caaggtggag atcaaacgaa ctgtggctgc 350

 accatctgtc ttcatcttcc cgccatctga tgagcagttg aaatctggaa 400

 ctgcttctgt tgtgtgcctg ctgaataact tctatcccag agaggccaaa 450

 gtacagtgga aggtggataa cgccctccaa tcgggtaact cccaggagag 500

 tgtcacagag caggacagca aggacagcac ctacagcctc agcagcaccc 550

 tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa 600

 gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg 650

 agagtgt 657

<210> 4
<211> 219
<212> PRT
<213> Artificial sequence

<220>
<223> Chimeric 2F2 Antibody - Light Chain

<400> 4
 Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile
   1               5                  10                  15

 Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro
                  35                  40                  45

 Gly Gln Ser Pro Glu Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val
                  80                  85                  90

 Tyr Cys Cys Trp Gln Gly Thr His Phe Pro Tyr Thr Phe Gly Gly
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val
                 110                 115                 120

 Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
                 125                 130                 135

 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
                 140                 145                 150

 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
                 155                 160                 165

 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                 170                 175                 180

 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
                 185                 190                 195

 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
                 200                 205                 210

 Thr Lys Ser Phe Asn Arg Gly Glu Cys
                 215                

<210> 5
<211> 1329
<212> DNA
<213> Artificial sequence

<220>
<223> Chimeric 2F2 Antibody - Heavy Chain

<400> 5
 caggttcaac tccagcaacc tggggctgag ctggtgaggc ctggggcttc 50

 agtgaagctg tcctgcaagg cttctggcta caccttcacc agctactgga 100

 tgaactgggt gaagcagagg cctggacaag gccttgaatg gattggtatg 150

 attgatcctt cagacagtga aactcactac aatcatatct tcaaggacaa 200

 ggccactttg actgtagaca aatcctccag cacagcctac ttgcagctca 250

 gcagcctgac atctgaggac tctgcggtct attactgtgc aagaaatctc 300

 tacttgtggg gtcaaggaac ctcagtcacc gtctccttag cctccaccaa 350

 gggcccatcg gtcttccccc tggcaccctc ctccaagagc acctctgggg 400

 gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg 450

 acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc 500

 ggctgtccta cagtcctcag gactctactc cctcagcagc gtggtgactg 550

 tgccctctag cagcttgggc acccagacct acatctgcaa cgtgaatcac 600

 aagcccagca acaccaaggt ggacaagaaa gttgagccca aatcttgtga 650

 caaaactcac acatgcccac cgtgcccagc acctgaactc ctggggggac 700

 cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 750

 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc 800

 tgaggtcaag ttcaactggt acgtggacgg cgtggaggtg cataatgcca 850

 agacaaagcc gcgggaggag cagtacaaca gcacgtaccg ggtggtcagc 900

 gtcctcaccg tcctgcacca ggactggctg aatggcaagg agtacaagtg 950

 caaggtctcc aacaaagccc tcccagcccc catcgagaaa accatctcca 1000

 aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1050

 cgggaagaga tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg 1100

 cttctatccc agcgacatcg ccgtggagtg ggagagcaat gggcagccgg 1150

 agaacaacta caagaccacg cctcccgtgc tggactccga cggctccttc 1200

 ttcctctaca gcaagctcac cgtggacaag agcaggtggc agcaggggaa 1250

 cgtcttctca tgctccgtga tgcatgaggc tctgcacaac cactacacgc 1300

 agaagagcct ctccctgtct  ccgggtaaa 1329

<210> 6
<211> 442
<212> PRT
<213> Artificial sequence

<220>
<223> Chimeric 2F2 Antibody - Heavy Chain

<400> 6
 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr
                  50                  55                  60

 Asn His Ile Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser
                  65                  70                  75

 Ser Ser Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Leu Trp Gly Gln
                  95                 100                 105

 Gly Thr Ser Val Thr Val Ser Leu Ala Ser Thr Lys Gly Pro Ser
                 110                 115                 120

 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
                 125                 130                 135

 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
                 140                 145                 150

 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                 155                 160                 165

 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
                 170                 175                 180

 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
                 185                 190                 195

 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
                 200                 205                 210

 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                 215                 220                 225

 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                 230                 235                 240

 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
                 245                 250                 255

 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                 260                 265                 270

 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
                 275                 280                 285

 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                 290                 295                 300

 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
                 305                 310                 315

 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                 320                 325                 330

 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
                 335                 340                 345

 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
                 350                 355                 360

 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
                 365                 370                 375

 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                 380                 385                 390

 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                 395                 400                 405

 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
                 410                 415                 420

 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                 425                 430                 435

 Ser Leu Ser Leu Ser Pro Gly
                 440        

<210> 7
<211> 231
<212> PRT
<213> Homo sapiens

<400> 7
 Met Ala Arg Leu Ala Leu Ser Pro Val Ser Ser His Trp Leu Val
   1               5                  10                  15

 Ala Leu Leu Leu Leu Leu Ser Ala Ala Glu Pro Val Pro Ala Ala
                  20                  25                  30

 Lys Ser Glu Asp Leu Tyr Pro Asn Pro Lys Gly Ser Ala Cys Ser
                  35                  40                  45

 Arg Ile Trp Gln Ser Pro Arg Phe Ile Ala Arg Lys Arg Gly Phe
                  50                  55                  60

 Thr Val Lys Met His Cys Tyr Val Thr Asn Ser Thr Phe Ser Ile
                  65                  70                  75

 Val Ser Trp Leu Arg Lys Arg Glu Thr Asp Lys Glu Pro Gln Gln
                  80                  85                  90

 Val Asn Leu Glu Gln Gly His Met His Gln Thr Gln Asn Ser Ser
                  95                 100                 105

 Val Thr Thr Leu Ile Ile Gln Asp Ile Arg Phe Glu Asp Asn Gly
                 110                 115                 120

 Ile Tyr Phe Cys Gln Gln Glu Cys Ser Lys Thr Ser Glu Val Tyr
                 125                 130                 135

 Arg Gly Cys Gly Thr Glu Leu Arg Val Met Gly Phe Ser Thr Leu
                 140                 145                 150

 Ala Gln Leu Lys Gln Arg Asn Thr Leu Lys Asp Gly Ile Ile Met
                 155                 160                 165

 Ile Gln Thr Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe
                 170                 175                 180

 Leu Leu Leu Asp Lys Asp Asp Ser Lys Ala Gly Met Glu Ala Asp
                 185                 190                 195

 His Thr Tyr Glu Gly Leu Asp Ile Asp Gln Thr Ala Thr Tyr Glu
                 200                 205                 210

 Asp Ile Val Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly
                 215                 220                 225

 Glu His Pro Gly Gln Glu
                 230    

<210> 8
<211> 228
<212> PRT
<213> Mus musculus

<400> 8
 Met Ala Thr Leu Val Leu Ser Ser Met Pro Cys His Trp Leu Leu
   1               5                  10                  15

 Phe Leu Leu Leu Leu Phe Ser Gly Glu Pro Val Pro Ala Met Thr
                  20                  25                  30

 Ser Ser Asp Leu Pro Leu Asn Phe Gln Gly Ser Pro Cys Ser Gln
                  35                  40                  45

 Ile Trp Gln His Pro Arg Phe Ala Ala Lys Lys Arg Ser Ser Met
                  50                  55                  60

 Val Lys Phe His Cys Tyr Thr Asn His Ser Gly Ala Leu Thr Trp
                  65                  70                  75

 Phe Arg Lys Arg Gly Ser Gln Gln Pro Gln Glu Leu Val Ser Glu
                  80                  85                  90

 Glu Gly Arg Ile Val Gln Thr Gln Asn Gly Ser Val Tyr Thr Leu
                  95                 100                 105

 Thr Ile Gln Asn Ile Gln Tyr Glu Asp Asn Gly Ile Tyr Phe Cys
                 110                 115                 120

 Lys Gln Lys Cys Asp Ser Ala Asn His Asn Val Thr Asp Ser Cys
                 125                 130                 135

 Gly Thr Glu Leu Leu Val Leu Gly Phe Ser Thr Leu Asp Gln Leu
                 140                 145                 150

 Lys Arg Arg Asn Thr Leu Lys Asp Gly Ile Ile Leu Ile Gln Thr
                 155                 160                 165

 Leu Leu Ile Ile Leu Phe Ile Ile Val Pro Ile Phe Leu Leu Leu
                 170                 175                 180

 Asp Lys Asp Asp Gly Lys Ala Gly Met Glu Glu Asp His Thr Tyr
                 185                 190                 195

 Glu Gly Leu Asn Ile Asp Gln Thr Ala Thr Tyr Glu Asp Ile Val
                 200                 205                 210

 Thr Leu Arg Thr Gly Glu Val Lys Trp Ser Val Gly Glu His Pro
                 215                 220                 225

 Gly Gln Glu
            

<210> 9
<211> 108
<212> PRT
<213> Homo sapiens

<400> 9
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser
                  20                  25                  30

 Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys
                  35                  40                  45

 Leu Leu Ile Tyr Ala Ala Ser Ser Leu Glu Ser Gly Val Pro Ser
                  50                  55                  60

 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile
                  65                  70                  75

 Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln
                  80                  85                  90

 Tyr Asn Ser Leu Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Glu
                  95                 100                 105

 Ile Lys Arg
            

<210> 10
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Variable Domain of Light Chain of Chimeric hu2F2

<400> 10
 Asp Ile Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile
   1               5                  10                  15

 Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro
                  35                  40                  45

 Gly Gln Ser Pro Glu Arg Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val
                  80                  85                  90

 Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Tyr Thr Phe Gly Gly
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 11
<211> 113
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of Light Chain of Humanized Antibody Graft (hu2F2 Graft)

<400> 11
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Trp Gln Gly Thr His Phe Pro Tyr Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 12
<211> 113
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of Light Chain of Humanized Antibody (hu2F2.D7)

<400> 12
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Thr His Phe Pro Phe Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg
                 110            

<210> 13
<211> 113
<212> PRT
<213> Homo sapiens

<400> 13
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Ser Val Ile Ser Gly Asp Gly Gly Ser Thr Tyr Tyr
                  50                  55                  60

 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser
                  65                  70                  75

 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Gly Phe Asp Tyr Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser
                 110            

<210> 14
<211> 113
<212> PRT
<213> Artificial Sequence

<220>
<223> Variable Domain of Heavy Chain of Chimeric 2F2

<400> 14
 Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Arg Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Lys Gln Arg Pro Gly Gln Gly Leu
                  35                  40                  45

 Glu Trp Ile Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr
                  50                  55                  60

 Asn His Ile Phe Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser
                  65                  70                  75

 Ser Ser Thr Ala Tyr Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp
                  80                  85                  90

 Ser Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Leu Trp Gly Gln
                  95                 100                 105

 Gly Thr Ser Val Thr Val Ser Leu
                 110            

<210> 15
<211> 113
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of Heavy Chain of Humanized Antibody Graft (hu2F2 Graft)

<400> 15
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr
                  50                  55                  60

 Asn His Ile Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Leu Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser
                 110            

<210> 16
<211> 113
<212> PRT
<213> Artificial sequence

<220>
<223> Variable Domain of Heavy Chain of Humanized Antibody (hu2F2.D7)

<400> 16
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr
                  50                  55                  60

 Asn His Ile Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Leu Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser
                 110            

<210> 17
<211> 8
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L3 (partial) of Humanized Antibody variant (hu2F2 Graft)

<400> 17
 Trp Gln Gly Thr His Phe Pro Tyr
                   5            

<210> 18
<211> 8
<212> PRT
<213> Artificial sequence

<220>
<223> Humanized Antibody Variant (HVR-L3 mutation)

<400> 18
 Phe Gln Gly Thr His Phe Pro Phe
                   5            

<210> 19
<211> 23
<212> PRT
<213> Artificial sequence

<220>
<223> FR1 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 19
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 20
<211> 15
<212> PRT
<213> Artificial sequence

<220>
<223> FR2 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 20
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 21
<211> 32
<212> PRT
<213> Artificial sequence

<220>
<223> FR3 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 21
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 22
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 22
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 23
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 23
 Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu
   1               5                  10                  15

 Asn
    

<210> 24
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 24
 Leu Val Ser Lys Leu Asp Ser
                   5        

<210> 25
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 25
 Phe Gln Gly Thr His Phe Pro Phe Thr
                   5                

<210> 26
<211> 106
<212> PRT
<213> Artificial sequence

<220>
<223> CL1 - LC of Humanized Antibody Variant (hu2F2.D7)

<400> 26
 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu
   1               5                  10                  15

 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn
                  20                  25                  30

 Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala
                  35                  40                  45

 Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser
                  50                  55                  60

 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys
                  65                  70                  75

 Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His
                  80                  85                  90

 Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu
                  95                 100                 105

 Cys
    

<210> 27
<211> 25
<212> PRT
<213> Artificial sequence

<220>
<223> FR1 - HC of Humanized Antibody Variant (hu2F2.D7)

<400> 27
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 28
<211> 13
<212> PRT
<213> Artificial sequence

<220>
<223> FR2 - HC of Humanized Antibody Variant (hu2F2.D7)

<400> 28
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 29
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> FR3 - HC of Humanized Antibody Variant (hu2F2.D7)

<400> 29
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 30
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> FR4 - HC of Humanized Antibody Variant (hu2F2.D7)

<400> 30
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 31
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> HVR1 - HC of Humanized Antibody Variant (hu2F2.D7)

<400> 31
 Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn
                   5                  10

<210> 32
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> HVR2 - HC of Humanized Antibody Variant (hu2F2.D7)

<400> 32
 Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn His Ile
   1               5                  10                  15

 Phe Lys Asp
            

<210> 33
<211> 6
<212> PRT
<213> Artificial sequence

<220>
<223> HVR3-HC of Humanized Antibody Variant (hu2F2.D7)

<400> 33
 Ala Arg Asn Leu Tyr Leu
                   5    

<210> 34
<211> 108
<212> PRT
<213> Artificial Sequence

<220>
<223> CH1 of HC of Humanized Antibody Variant (hu2F2.D7)

<400> 34
 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser
   1               5                  10                  15

 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys
                  20                  25                  30

 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala
                  35                  40                  45

 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser
                  50                  55                  60

 Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser
                  65                  70                  75

 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser
                  80                  85                  90

 Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys
                  95                 100                 105

 Thr His Thr
            

<210> 35
<211> 221
<212> PRT
<213> Artificial Sequence

<220>
<223> Fc of HC of Humanized Antibody Variant (hu2F2.D7)

<400> 35
 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
   1               5                  10                  15

 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg
                  20                  25                  30

 Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp
                  35                  40                  45

 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His
                  50                  55                  60

 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr
                  65                  70                  75

 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
                  80                  85                  90

 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                  95                 100                 105

 Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu
                 110                 115                 120

 Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys
                 125                 130                 135

 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser
                 140                 145                 150

 Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn
                 155                 160                 165

 Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
                 170                 175                 180

 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly
                 185                 190                 195

 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His
                 200                 205                 210

 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly
                 215                 220    

<210> 36
<211> 87
<212> PRT
<213> Homo sapiens

<400> 36
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met Gly Arg
                  35                  40                  45

 Val Thr Ile Thr Ala Asp Thr Ser Thr Ser Thr Ala Tyr Met Glu
                  50                  55                  60

 Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 37
<211> 81
<212> PRT
<213> Homo sapiens

<400> 37
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 38
<211> 80
<212> PRT
<213> Homo sapiens

<400> 38
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 39
<211> 79
<212> PRT
<213> Homo sapiens

<400> 39
 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly
   1               5                  10                  15

 Ala Ser Val Lys Val Ser Cys Lys Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Gln Gly Leu Glu Trp Met Arg Val Thr Ile Thr Ala Asp
                  35                  40                  45

 Thr Ser Thr Ser Thr Ala Tyr Met Glu Leu Ser Ser Leu Arg Ser
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 40
<211> 87
<212> PRT
<213> Homo sapiens

<400> 40
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser
                  20                  25                  30

 Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly Arg
                  35                  40                  45

 Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu Lys
                  50                  55                  60

 Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 41
<211> 81
<212> PRT
<213> Homo sapiens

<400> 41
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 42
<211> 80
<212> PRT
<213> Homo sapiens

<400> 42
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 43
<211> 79
<212> PRT
<213> Homo sapiens

<400> 43
 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser
   1               5                  10                  15

 Gln Thr Leu Ser Leu Thr Cys Thr Val Ser Trp Ile Arg Gln Pro
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Ile Arg Val Thr Ile Ser Val Asp
                  35                  40                  45

 Thr Ser Lys Asn Gln Phe Ser Leu Lys Leu Ser Ser Val Thr Ala
                  50                  55                  60

 Ala Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 44
<211> 87
<212> PRT
<213> Homo sapiens

<400> 44
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 45
<211> 81
<212> PRT
<213> Homo sapiens

<400> 45
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 46
<211> 80
<212> PRT
<213> Homo sapiens

<400> 46
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 47
<211> 79
<212> PRT
<213> Homo sapiens

<400> 47
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Arg Asp
                  35                  40                  45

 Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 48
<211> 87
<212> PRT
<213> Homo sapiens

<400> 48
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ser
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 49
<211> 81
<212> PRT
<213> Homo sapiens

<400> 49
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ser Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 50
<211> 80
<212> PRT
<213> Homo sapiens

<400> 50
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ser Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 51
<211> 87
<212> PRT
<213> Homo sapiens

<400> 51
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Asn Ile Lys
                  20                  25                  30

 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ser Arg
                  35                  40                  45

 Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu Gln
                  50                  55                  60

 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                  65                  70                  75

 Arg Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                  80                  85        

<210> 52
<211> 81
<212> PRT
<213> Homo sapiens

<400> 52
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Trp Gly Gln Gly Thr
                  65                  70                  75

 Leu Val Thr Val Ser Ser
                  80    

<210> 53
<211> 80
<212> PRT
<213> Homo sapiens

<400> 53
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Ala Trp Gly Gln Gly Thr Leu
                  65                  70                  75

 Val Thr Val Ser Ser
                  80

<210> 54
<211> 79
<212> PRT
<213> Homo sapiens

<400> 54
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Trp Val Arg Gln Ala
                  20                  25                  30

 Pro Gly Lys Gly Leu Glu Trp Val Arg Phe Thr Ile Ser Ala Asp
                  35                  40                  45

 Thr Ser Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala
                  50                  55                  60

 Glu Asp Thr Ala Val Tyr Tyr Cys Trp Gly Gln Gly Thr Leu Val
                  65                  70                  75

 Thr Val Ser Ser
                

<210> 55
<211> 80
<212> PRT
<213> Homo sapiens

<400> 55
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Lys Ala Pro Lys Leu Leu Ile Tyr Gly Val Pro Ser Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  50                  55                  60

 Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 56
<211> 80
<212> PRT
<213> Homo sapiens

<400> 56
 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro
   1               5                  10                  15

 Gly Glu Pro Ala Ser Ile Ser Cys Trp Tyr Leu Gln Lys Pro Gly
                  20                  25                  30

 Gln Ser Pro Gln Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val
                  50                  55                  60

 Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 57
<211> 80
<212> PRT
<213> Homo sapiens

<400> 57
 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro
   1               5                  10                  15

 Gly Glu Arg Ala Thr Leu Ser Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ile Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu
                  50                  55                  60

 Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 58
<211> 80
<212> PRT
<213> Homo sapiens

<400> 58
 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu
   1               5                  10                  15

 Gly Glu Arg Ala Thr Ile Asn Cys Trp Tyr Gln Gln Lys Pro Gly
                  20                  25                  30

 Gln Pro Pro Lys Leu Leu Ile Tyr Gly Val Pro Asp Arg Phe Ser
                  35                  40                  45

 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu
                  50                  55                  60

 Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Phe Gly Gln Gly Thr
                  65                  70                  75

 Lys Val Glu Ile Lys
                  80

<210> 59
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR1-LC of hu2F2 graft

<400> 59
 Lys Ser Ser Gln Ser Leu Leu Asp Ser Asp Gly Lys Thr Tyr Leu
   1               5                  10                  15

 Asn
    

<210> 60
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR2-LC of hu2F2 graft

<400> 60
 Leu Val Ser Lys Leu Asp Ser
                   5        

<210> 61
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR3-LC of hu2F2 graft

<400> 61
 Trp Gln Gly Thr His Phe Pro Tyr Thr
                   5                

<210> 62
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR1-HC of hu2F2 graft

<400> 62
 Gly Tyr Thr Phe Thr Ser Tyr Trp Met Asn
                   5                  10

<210> 63
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR2-HC of hu2F2 graft

<400> 63
 Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr Asn His Ile
   1               5                  10                  15

 Phe Lys Asp
            

<210> 64
<211> 6
<212> PRT
<213> Artificial Sequence

<220>
<223> HVR3-HC of 2F2 graft

<400> 64
 Ala Arg Asn Leu Tyr Leu
                   5    

<210> 65
<211> 23
<212> PRT
<213> Homo sapiens

<400> 65
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys
                  20            

<210> 66
<211> 15
<212> PRT
<213> Homo sapiens

<400> 66
 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr
   1               5                  10                  15

<210> 67
<211> 32
<212> PRT
<213> Homo sapiens

<400> 67
 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe
   1               5                  10                  15

 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr
                  20                  25                  30

 Tyr Cys
        

<210> 68
<211> 11
<212> PRT
<213> Homo sapiens

<400> 68
 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg
                   5                  10    

<210> 69
<211> 25
<212> PRT
<213> Homo sapiens

<400> 69
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser
                  20                  25

<210> 70
<211> 13
<212> PRT
<213> Homo sapiens

<400> 70
 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
                   5                  10            

<210> 71
<211> 30
<212> PRT
<213> Homo sapiens

<400> 71
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 72
<211> 11
<212> PRT
<213> Homo sapiens

<400> 72
 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
                   5                  10    

<210> 73
<211> 30
<212> PRT
<213> Artificial Sequence

<220>
<223> Xaa = A or N

<400> 73
 Arg Phe Thr Ile Ser Xaa Asp Xaa Ser Lys Asn Thr Xaa Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

<210> 74
<211> 31
<212> PRT
<213> Homo sapiens

<400> 74
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala
    

<210> 75
<211> 32
<212> PRT
<213> Homo sapiens

<400> 75
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ala Arg
        

<210> 76
<211> 31
<212> PRT
<213> Homo sapiens

<400> 76
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ser
    

<210> 77
<211> 32
<212> PRT
<213> Homo sapiens

<400> 77
 Arg Phe Thr Ile Ser Ala Asp Thr Ser Lys Asn Thr Ala Tyr Leu
   1               5                  10                  15

 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                  20                  25                  30

 Ser Arg
        

<210> 78
<211> 16
<212> PRT
<213> Artificial sequence

<220>
<223> Peptide Containing Epitope

<400> 78
 Ala Arg Ser Glu Asp Arg Tyr Arg Asn Pro Lys Gly Ser Ala Cys
   1               5                  10                  15

 Lys
    

<210> 79
<211> 9
<212> PRT
<213> Artificial sequence

<220>
<223> HVR-L3 of Humanized Antibody Variant (hu2F2.D7)

<400> 79
 Phe Gln Gly Thr His Phe Pro Phe Thr
                   5                

<210> 80
<211> 30
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin Binding Peptide

<400> 80
 Cys Asp Lys Thr His Thr Gly Gly Gly Ser Gln Arg Leu Met Glu
   1               5                  10                  15

 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp Glu Asp Asp Phe
                  20                  25                  30

<210> 81
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin Binding Peptide

<400> 81
 Gln Arg Leu Met Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu
   1               5                  10                  15

 Trp Glu Asp Asp Phe
                  20

<210> 82
<211> 20
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin Binding Peptide

<400> 82
 Gln Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu
   1               5                  10                  15

 Trp Glu Asp Asp Phe
                  20

<210> 83
<211> 18
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin Binding Peptide

<400> 83
 Arg Leu Ile Glu Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
   1               5                  10                  15

 Glu Asp Asp
            

<210> 84
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Albumin Binding Peptide

<400> 84
 Asp Ile Cys Leu Pro Arg Trp Gly Cys Leu Trp
                   5                  10    

<210> 85
<211> 442
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-CD79b (hu2F2.D7)-HC(A118C) Variant - HC

<400> 85
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr
                  50                  55                  60

 Asn His Ile Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Leu Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro Ser
                 110                 115                 120

 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
                 125                 130                 135

 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
                 140                 145                 150

 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                 155                 160                 165

 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
                 170                 175                 180

 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
                 185                 190                 195

 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
                 200                 205                 210

 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                 215                 220                 225

 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                 230                 235                 240

 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
                 245                 250                 255

 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                 260                 265                 270

 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
                 275                 280                 285

 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                 290                 295                 300

 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
                 305                 310                 315

 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                 320                 325                 330

 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
                 335                 340                 345

 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
                 350                 355                 360

 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
                 365                 370                 375

 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                 380                 385                 390

 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                 395                 400                 405

 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
                 410                 415                 420

 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                 425                 430                 435

 Ser Leu Ser Leu Ser Pro Gly
                 440        

<210> 86
<211> 219
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-CD79b (hu2F2.D7)-HC(A118C) Variant - LC

<400> 86
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Thr His Phe Pro Phe Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val
                 110                 115                 120

 Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
                 125                 130                 135

 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
                 140                 145                 150

 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
                 155                 160                 165

 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                 170                 175                 180

 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
                 185                 190                 195

 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
                 200                 205                 210

 Thr Lys Ser Phe Asn Arg Gly Glu Cys
                 215                

<210> 87
<211> 442
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-DC79b (hu2F2.D7)-LC(V205C) Variant -HC

<400> 87
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr
                  50                  55                  60

 Asn His Ile Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Leu Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
                 110                 115                 120

 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
                 125                 130                 135

 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
                 140                 145                 150

 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                 155                 160                 165

 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
                 170                 175                 180

 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
                 185                 190                 195

 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
                 200                 205                 210

 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                 215                 220                 225

 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                 230                 235                 240

 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
                 245                 250                 255

 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                 260                 265                 270

 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
                 275                 280                 285

 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                 290                 295                 300

 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
                 305                 310                 315

 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                 320                 325                 330

 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
                 335                 340                 345

 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
                 350                 355                 360

 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
                 365                 370                 375

 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                 380                 385                 390

 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                 395                 400                 405

 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
                 410                 415                 420

 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                 425                 430                 435

 Ser Leu Ser Leu Ser Pro Gly
                 440        

<210> 88
<211> 219
<212> PRT
<213> Artificial sequence

<220>
<223> Thio anti-CD79b(hu2F2.D7)-LC(V205C)Variant-LC

<400> 88
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Thr His Phe Pro Phe Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val
                 110                 115                 120

 Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
                 125                 130                 135

 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
                 140                 145                 150

 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
                 155                 160                 165

 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                 170                 175                 180

 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
                 185                 190                 195

 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Cys
                 200                 205                 210

 Thr Lys Ser Phe Asn Arg Gly Glu Cys
                 215                

<210> 89
<211> 219
<212> PRT
<213> Artificial sequence

<220>
<223> LIght Chain of hu2F2.D7 Antibody

<400> 89
 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val
   1               5                  10                  15

 Gly Asp Arg Val Thr Ile Thr Cys Lys Ser Ser Gln Ser Leu Leu
                  20                  25                  30

 Asp Ser Asp Gly Lys Thr Tyr Leu Asn Trp Tyr Gln Gln Lys Pro
                  35                  40                  45

 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Leu Val Ser Lys Leu Asp
                  50                  55                  60

 Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp
                  65                  70                  75

 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr
                  80                  85                  90

 Tyr Tyr Cys Phe Gln Gly Thr His Phe Pro Phe Thr Phe Gly Gln
                  95                 100                 105

 Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val
                 110                 115                 120

 Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala
                 125                 130                 135

 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
                 140                 145                 150

 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
                 155                 160                 165

 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu
                 170                 175                 180

 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys
                 185                 190                 195

 Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val
                 200                 205                 210

 Thr Lys Ser Phe Asn Arg Gly Glu Cys
                 215                

<210> 90
<211> 442
<212> PRT
<213> Artificial sequence

<220>
<223> Heavy chain of hu2F2.D7 Antibody

<400> 90
 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly
   1               5                  10                  15

 Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Tyr Thr Phe Thr
                  20                  25                  30

 Ser Tyr Trp Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu
                  35                  40                  45

 Glu Trp Val Gly Met Ile Asp Pro Ser Asp Ser Glu Thr His Tyr
                  50                  55                  60

 Asn His Ile Phe Lys Asp Arg Phe Thr Ile Ser Ala Asp Thr Ser
                  65                  70                  75

 Lys Asn Thr Ala Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp
                  80                  85                  90

 Thr Ala Val Tyr Tyr Cys Ala Arg Asn Leu Tyr Leu Trp Gly Gln
                  95                 100                 105

 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser
                 110                 115                 120

 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
                 125                 130                 135

 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
                 140                 145                 150

 Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr
                 155                 160                 165

 Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser
                 170                 175                 180

 Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile
                 185                 190                 195

 Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys
                 200                 205                 210

 Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
                 215                 220                 225

 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro
                 230                 235                 240

 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val
                 245                 250                 255

 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys
                 260                 265                 270

 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr
                 275                 280                 285

 Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser
                 290                 295                 300

 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr
                 305                 310                 315

 Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
                 320                 325                 330

 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr
                 335                 340                 345

 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser
                 350                 355                 360

 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
                 365                 370                 375

 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
                 380                 385                 390

 Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys
                 395                 400                 405

 Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser
                 410                 415                 420

 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys
                 425                 430                 435

 Ser Leu Ser Leu Ser Pro Gly
                 440        

<210> 91
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 91
 Glu Val Gln Leu Cys Glu Ser Gly Gly Gly
                   5                  10

<210> 92
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 92
 Leu Arg Leu Ser Cys Cys Ala Ser Gly Tyr Thr
                   5                  10    

<210> 93
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 93
 Met Asn Ser Leu Arg Cys Glu Asp Thr Ala Val
                   5                  10    

<210> 94
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 94
 Thr Leu Val Thr Val Cys Ser Ala Ser Thr Lys
                   5                  10    

<210> 95
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 95
 Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 96
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 96
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 97
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 97
 Lys Phe Asn Trp Tyr Cys Asp Gly Val Glu Val
                   5                  10    

<210> 98
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 98
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 99
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-HC-Variant

<400> 99
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 100
<211> 10
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 100
 Gln Val Gln Leu Cys Gln Pro Gly Ala Glu
                   5                  10

<210> 101
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 101
 Val Lys Leu Ser Cys Cys Ala Ser Gly Tyr Thr
                   5                  10    

<210> 102
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 102
 Leu Ser Ser Leu Thr Cys Glu Asp Ser Ala Val
                   5                  10    

<210> 103
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 103
 Thr Ser Val Thr Val Cys Leu Ala Ser Thr Lys
                   5                  10    

<210> 104
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 104
 Val Thr Val Ser Ser Cys Ser Thr Lys Gly Pro
                   5                  10    

<210> 105
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 105
 Val Ser Ser Ala Ser Cys Lys Gly Pro Ser Val
                   5                  10    

<210> 106
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 106
 Lys Phe Asn Trp Tyr Cys Asp Gly Val Glu Val
                   5                  10    

<210> 107
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 107
 Lys Gly Phe Tyr Pro Cys Asp Ile Ala Val Glu
                   5                  10    

<210> 108
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-HC-variant

<400> 108
 Pro Pro Val Leu Asp Cys Asp Gly Ser Phe Phe
                   5                  10    

<210> 109
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-LC-variant

<400> 109
 Ser Leu Ser Ala Ser Cys Gly Asp Arg Val Thr
                   5                  10    

<210> 110
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-LC-variant

<400> 110
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 111
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-LC-variant

<400> 111
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 112
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-LC-variant

<400> 112
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 113
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-LC-variant

<400> 113
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 114
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-LC-variant

<400> 114
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 115
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-hu2F2-LC-variant

<400> 115
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

<210> 116
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-LC-variant

<400> 116
 Thr Leu Ser Val Thr Cys Gly Gln Pro Ala Ser
                   5                  10    

<210> 117
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-LC-variant

<400> 117
 Glu Ile Lys Arg Thr Cys Ala Ala Pro Ser Val
                   5                  10    

<210> 118
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-LC-variant

<400> 118
 Thr Val Ala Ala Pro Cys Val Phe Ile Phe Pro
                   5                  10    

<210> 119
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-LC-variant

<400> 119
 Phe Ile Phe Pro Pro Cys Asp Glu Gln Leu Lys
                   5                  10    

<210> 120
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-LC-variant

<400> 120
 Asp Glu Gln Leu Lys Cys Gly Thr Ala Ser Val
                   5                  10    

<210> 121
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (ch2F2)-LC-variant

<400> 121
 Val Thr Glu Gln Asp Cys Lys Asp Ser Thr Tyr
                   5                  10    

<210> 122
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> Thio-anti-CD79b (2chF2)-LC-variant

<400> 122
 Gly Leu Ser Ser Pro Cys Thr Lys Ser Phe Asn
                   5                  10    

