
                                SEQUENCE LISTING

<110> GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE
      SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, THE
      Goncalvez, Ana P.
      Purcell, Robert H.
      Lai, Ching-Juh
      

<120> MONOCLONAL ANTIBODIES AGAINST DENGUE AND
  OTHER VIRUSES WITH DELETION IN FC REGION
  

<130> NIH355.001VPC

<150> 60/922282           
<151> 2007-04-04  

<150> 60/927755           
<151> 2007-05-04  

<150> 60/928405           
<151> 2007-05-08  

<160> 58

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 1
Leu Leu Gly Gly
 1              


<210> 2
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 2
Glu Leu Leu Gly Gly
 1               5  


<210> 3
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 3
Leu Leu Gly Gly Pro
 1               5  


<210> 4
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 4
Pro Glu Leu Leu Gly Gly
 1               5      


<210> 5
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 5
Glu Leu Leu Gly Gly Pro
 1               5      


<210> 6
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 6
Leu Leu Gly Gly Pro Ser
 1               5      


<210> 7
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 7
Ala Pro Glu Leu Leu Gly Gly
 1               5          


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 8
Pro Glu Leu Leu Gly Gly Pro
 1               5          


<210> 9
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 9
Glu Leu Leu Gly Gly Pro Ser
 1               5          


<210> 10
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 10
Leu Leu Gly Gly Pro Ser Val
 1               5          


<210> 11
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 11
Pro Ala Pro Glu Leu Leu Gly Gly
 1               5              


<210> 12
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 12
Ala Pro Glu Leu Leu Gly Gly Pro
 1               5              


<210> 13
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 13
Pro Glu Leu Leu Gly Gly Pro Ser
 1               5              


<210> 14
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 14
Glu Leu Leu Gly Gly Pro Ser Val
 1               5              


<210> 15
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 15
Pro Ala Pro Glu Leu Leu Gly Gly Pro
 1               5                  


<210> 16
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 16
Ala Pro Glu Leu Leu Gly Gly Pro Ser
 1               5                  


<210> 17
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 17
Pro Glu Leu Leu Gly Gly Pro Ser Val
 1               5                  


<210> 18
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 18
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser
 1               5                  10  


<210> 19
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Fc region partial sequence

<400> 19
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val
 1               5                  10  


<210> 20
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 20
ctcttggcag gatttatggc tta                                         23

<210> 21
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 21
caaagaagac agttcgctgg att                                         23

<210> 22
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe

<400> 22
atgattgggc aaacag                                                 16

<210> 23
<211> 9
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG 1A5 Delta B substituted sequence

<400> 23
accggtcgc                                                         9

<210> 24
<211> 12
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG 1A5 partial sequence

<400> 24
tgaactcctg gg                                                     12

<210> 25
<211> 6
<212> DNA
<213> Artificial Sequence

<220> 
<223> AgeI site

<400> 25
accggt                                                            6

<210> 26
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Anti-sense primer

<400> 26
tttacccgga gacagggaga gg                                          22

<210> 27
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG1 1A5 partial sequence

<400> 27
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Pro Lys Pro
            20          


<210> 28
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG1 AF237583 partial sequence

<400> 28
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Pro Lys Pro
            20          


<210> 29
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG2 AH013417 partial sequence

<400> 29
Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu
 1               5                  10                  15      
Phe Pro Pro Lys Pro
            20      


<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG2 AY372690 partial sequence

<400> 30
Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu
 1               5                  10                  15      
Phe Pro Pro Lys Pro
            20      


<210> 31
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG3 AJ390253 partial sequence

<400> 31
Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Pro Lys Pro
            20          


<210> 32
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223>  IgG3 AJ390265 partial sequence

<400> 32
Cys Pro Arg Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Pro Lys Pro
            20          


<210> 33
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223>  IgG4 AF237586 partial sequence

<400> 33
Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Pro Lys Pro
            20          


<210> 34
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5 WT partial sequence

<400> 34
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys
            20                  25                  30          
Thr Ile
        


<210> 35
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5  A partial sequence

<400> 35
Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe
 1               5                  10                  15      
Leu Phe Pro Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys
            20                  25                  30          
Thr Ile
        


<210> 36
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5  B partial sequence

<400> 36
Cys Pro Pro Cys Pro Ala Pro Pro Val Glu Gly Pro Ser Val Phe Leu
 1               5                  10                  15      
Phe Pro Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr
            20                  25                  30          
Ile
    


<210> 37
<211> 33
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5  C partial sequence

<400> 37
Cys Pro Pro Cys Pro Ala Pro Pro Val Glu Gly Pro Ser Val Phe Leu
 1               5                  10                  15      
Phe Pro Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr
            20                  25                  30          
Ile
    


<210> 38
<211> 25
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5  D partial sequence

<400> 38
Cys Pro Pro Cys Pro Val Phe Leu Phe Pro Lys Val Ser Asn Lys Ala
 1               5                  10                  15      
Leu Pro Ala Pro Ile Glu Lys Thr Ile
            20                  25  


<210> 39
<211> 81
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG 1A5 WT partial sequence

<400> 39
tgtccaccgt gcccaggtaa gccagccctc tcttcctcag cacctgaact cctgggggga 60
ccgtcagtct tcctcttccc c                                           81

<210> 40
<211> 81
<212> DNA
<213> Artificial Sequence

<220> 
<223> IgG 5H2  D partial sequence

<400> 40
tgtccaccgt gcccaggtaa gccagccctc tcttcctcgg cacctgaact cctgggggga 60
ccgtcagtct tcctcttccc c                                           81

<210> 41
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> DENV-4 wt partial sequence

<400> 41
Ser Pro Ser Val Glu Val Lys Leu Pro Asp Tyr Gly Glu Leu Thr Leu
 1               5                  10                  15      
Asp Cys
        


<210> 42
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> DENV-4 v3 partial sequence

<400> 42
Ser Pro Ser Val Glu Val Glu Leu Pro Asp Tyr Gly Glu Leu Thr Leu
 1               5                  10                  15      
Asp Cys
        


<210> 43
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> DENV-4 v4 partial sequence

<400> 43
Ser Pro Ser Val Glu Val Lys Leu Leu Asp Tyr Gly Glu Leu Thr Leu
 1               5                  10                  15      
Asp Cys
        


<210> 44
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> DENV-3 partial sequence

<400> 44
Ala Ser Thr Ala Glu Ala Ile Leu Pro Glu Tyr Gly Thr Leu Gly Leu
 1               5                  10                  15      
Glu Cys
        


<210> 45
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> DENV-2 partial sequence

<400> 45
Ser Ser Ile Thr Glu Ala Glu Leu Thr Gly Tyr Gly Thr Val Thr Met
 1               5                  10                  15      
Glu Cys
        


<210> 46
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> DENV-1 partial sequence

<400> 46
Ala Pro Thr Ser Glu Ile Gln Leu Thr Asp Tyr Gly Ala Leu Thr Leu
 1               5                  10                  15      
Asp Cys
        


<210> 47
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> JEV partial sequence

<400> 47
Ala Pro Ser Ile Thr Leu Lys Leu Gly Asp Tyr Gly Glu Val Thr Leu
 1               5                  10                  15      
Asp Cys
        


<210> 48
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> WNV partial sequence

<400> 48
Ala Pro Ser Tyr Thr Leu Lys Leu Gly Asp Tyr Gly Glu Val Thr Leu
 1               5                  10                  15      
Asp Cys
        


<210> 49
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> TBEV partial sequence

<400> 49
Ser Glu Lys Thr Ile Leu Thr Met Glu Gly Tyr Gly Asp Val Ser Leu
 1               5                  10                  15      
Leu Cys
        


<210> 50
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> YFV partial sequence

<400> 50
Ser Gly Ser Gln Glu Val Glu Phe Ile Gly Tyr Gly Lys Ala Thr Leu
 1               5                  10                  15      
Glu Cys
        


<210> 51
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5 WT Heavy Chain Fc Region

<400> 51
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 52
<211> 330
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 5H2 WT Heavy Chain Fc Region

<400> 52
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
 1               5                  10                  15      
Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
            20                  25                  30          
Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
        35                  40                  45              
Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
    50                  55                  60                  
Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
65                  70                  75                  80  
Tyr Ile Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys
                85                  90                  95      
Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110         
Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125             
Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140                 
Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 
Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175     
Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190         
His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205             
Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220                 
Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 
Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255     
Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270         
Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285             
Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300                 
Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 
Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330 


<210> 53
<211> 452
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5 WT Heavy Chain

<400> 53
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Arg Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Ile Ser Asp Asn
            20                  25                  30          
Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ala Leu Ile Tyr Ser Ala Asp Thr Thr His Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Glu Tyr Cys Thr Gly Asp Thr Cys Phe Ala His Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Ser Val Ser Ser Ala Ser Thr Lys Gly Pro
        115                 120                 125             
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr
    130                 135                 140                 
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr
145                 150                 155                 160 
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro
                165                 170                 175     
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr
            180                 185                 190         
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asp
        195                 200                 205             
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser
    210                 215                 220                 
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu
225                 230                 235                 240 
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu
                245                 250                 255     
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser
            260                 265                 270         
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu
        275                 280                 285             
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr
    290                 295                 300                 
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn
305                 310                 315                 320 
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro
                325                 330                 335     
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln
            340                 345                 350         
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val
        355                 360                 365             
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val
    370                 375                 380                 
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro
385                 390                 395                 400 
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr
                405                 410                 415     
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val
            420                 425                 430         
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu
        435                 440                 445             
Ser Pro Gly Lys
    450         


<210> 54
<211> 453
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 5H2 WT Heavy Chain

<400> 54
Glu Val Gln Leu Leu Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu
 1               5                  10                  15      
Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Asp Phe
            20                  25                  30          
Tyr Trp Ser Trp Leu Arg Gln Ser Pro Gly Lys Gly Leu Glu Trp Ile
        35                  40                  45              
Gly Tyr Ala His Ser Arg Val Ser Ala Tyr Tyr Asn Pro Ser Leu Lys
    50                  55                  60                  
Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Leu Ser Leu
65                  70                  75                  80  
Arg Leu Ser Ala Val Thr Ala Ala Asp Thr Ala Leu Tyr Tyr Cys Ala
                85                  90                  95      
Arg Gln Gly Thr Gly Thr Thr Gly Val Ser Glu Asp Phe Phe Asp Leu
            100                 105                 110         
Trp Gly Gln Gly Thr Lys Val Ile Val Ser Leu Ala Ser Thr Lys Gly
        115                 120                 125             
Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly
    130                 135                 140                 
Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val
145                 150                 155                 160 
Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe
                165                 170                 175     
Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val
            180                 185                 190         
Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val
        195                 200                 205             
Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys
    210                 215                 220                 
Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu
225                 230                 235                 240 
Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr
                245                 250                 255     
Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val
            260                 265                 270         
Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val
        275                 280                 285             
Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser
    290                 295                 300                 
Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu
305                 310                 315                 320 
Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala
                325                 330                 335     
Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro
            340                 345                 350         
Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln
        355                 360                 365             
Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala
    370                 375                 380                 
Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr
385                 390                 395                 400 
Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu
                405                 410                 415     
Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser
            420                 425                 430         
Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser
        435                 440                 445             
Leu Ser Pro Gly Lys
    450             


<210> 55
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5 WT  CH2 domain

<400> 55
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 56
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 5H2 WT  CH2 domain

<400> 56
Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys
 1               5                  10                  15      
Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val
            20                  25                  30          
Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr
        35                  40                  45              
Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu
    50                  55                  60                  
Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His
65                  70                  75                  80  
Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys
                85                  90                  95      
Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys
            100                 105                 110 


<210> 57
<211> 209
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 1A5 WT Light Chain

<400> 57
Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Thr Val Thr Ile Ala Cys Arg Ala Ser Gln Ser Ile Thr Asn Tyr
            20                  25                  30          
Leu Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr His Ala Ser Thr Leu Gln Ser Gly Ile Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Asp Asp Phe Ala Thr Tyr Tyr Cys His Tyr Gly Tyr Gly Thr His Thr
                85                  90                  95      
Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro
            100                 105                 110         
Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr
        115                 120                 125             
Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys
    130                 135                 140                 
Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu
145                 150                 155                 160 
Ser Val Thr Glu Gln Asp Ser Lys Asp Asn Thr Tyr Ser Leu Ser Ser
                165                 170                 175     
Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala
            180                 185                 190         
Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe
        195                 200                 205             
Asn
    


<210> 58
<211> 210
<212> PRT
<213> Artificial Sequence

<220> 
<223> IgG 5H2 WT Light Chain

<400> 58
Glu Leu Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly
 1               5                  10                  15      
Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Ser Ile Arg
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile
        35                  40                  45              
Tyr Asp Ala Ser Thr Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro
65                  70                  75                  80  
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Leu
                85                  90                  95      
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Asn Thr Tyr Ser Leu Ser
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser
        195                 200                 205             
Phe Asn
    210 

