
                                SEQUENCE LISTING

<110> OCEAN NUTRITION CANADA LTD
      Burja, Adam M.
      Girouard, Gabrielle S.
      Radianingtyas, Helia

<120> D4 DESATURASES AND D5 ELONGASES
  

<130> 15113.0032P1

<150> 60/949,730          
<151> 2007-07-13  

<160> 26

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic forward primer

<400> 1
ggracagcga sttttacagg g                                           21

<210> 2
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic reverse primer

<400> 2
gtgctcaatc tggtggttka g                                           21

<210> 3
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic forward primer

<400> 3
aagccyttcg agctcaagty c                                           21

<210> 4
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic reverse primer

<400> 4
gcacgaaraa gttgccgaag                                             20

<210> 5
<211> 1003
<212> DNA
<213> Artificial Sequence

<220> 
<223> 600-16 clone without vector sequence synthesized
      from recombinant plasmid

<400> 5
aagcctttcg agctcaagtc catcacgccg tcatgcgatc tccgccctcc gctgcttctt 60
ctcgagcttt ggcagagccg ccgcattgcg aactgccgcc atcccatcgg tcgttgcagc 120
acccggtaag tctgctgacc aggaggggct gggagcgaag agggcgtaca gcggagaggt 180
agcgctcaag ctcagacctc cagcgcccga agcaagattt tggtcattgg cccgggccct 240
gaccagattc tcgaggtctc ggactcgtct tctggtgact ctcatgagac tggattctcg 300
ccttcgccaa tgaactcgtc tgtagtcccc atatatcgat ccgtgtcgac atcgcatctc 360
ccggacctct cctccacccg cgacactctt gactcctcct tcggcaactt tttcgtgaag 420
cctttcgagc tcaagtccct gaagctcgtg cacaacatct ttctcaccgg tctgtccctg 480
tacatggcta gcgagtgcgc gcgccaggcc tacctcggcg gctacaagct ctttggcaac 540
ccgatggaga agggtgccga gtctcacgcc ctaggcatgg ctagcattat ctacgttttt 600
tacgtgagca agttcctcga gtttcttgac acggtcttca tgatcctcgg caagaagtgg 660
aagcagctca gctttcttca cgtctaccac cacgcgagca tcagcttcat ctggggcatt 720
atcgcccgtt ttgcgcccgg tggcgacgcg tacttttcca ccatcctcaa cagcagcgtg 780
catgtcgtgc tctacggcta ctacgcctcg accacgctcg gctacacctt catgcgcccg 840
ctgcgcccgt acattactac catccagctc acgcagttca tggccatggt cgtccagtcc 900
gtctatgact actacaaccc ttgcgactac ccgcagcccc tcgtcaagct actcttctgg 960
tacatgctca ccatgctcgg cctcttcggc aacttcttcg tgc                   1003

<210> 6
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 6
cgctgcgccc gtacattact accatcca                                    28

<210> 7
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 7
gtcgtccagt ccgtctatga c                                           21

<210> 8
<211> 358
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3'C2-1 clone synthesized from recombinant plasmid

<400> 8
tactacaacc cttgcgacta cccgcagccc ctcgtcaagc tactcttctg gtacatgctc 60
accatgctcg gccttttcgg caacttcttc gtgcagcagt acctcaagcc caaggcgcct 120
aagaagcaaa agaccatctg agccgagtcc catcccaaaa tacgtcacgc aagtgcgtac 180
tagtgggagt gaggggctgc aagtactact tattggtcac cgggtaagac cgctagaccg 240
caacttgtct tgaagcatag attgttgatt ctgtcgctac gaattcgagt ggaccccgga 300
ggtaaacgac gcgtgttcaa gggcgaattc gtttaaacct gcaggactag tcccttta   358

<210> 9
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 9
ctcggcaccc ttctccatcg ggttgcca                                    28

<210> 10
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic oligonucleotide

<400> 10
gttgccaaag agcttgtagc cgccga                                      26

<210> 11
<211> 519
<212> DNA
<213> Artificial Sequence

<220> 
<223> 5'D2-11 clone synthesized from recombinant plasmid

<400> 11
gagcttgtag ccgccgaggt aggcctggcg cgcgcactcg ctagccatgt acagggacag 60
accggtgaga aagatgttgt gcacgagctt caggaacttg agctcgaaag gcttactcac 120
aaaggccgtc atgaaggcag acccgagaac cacgaacgcc aggtagccga cgatgagcgc 180
catcatctcc tcggtcgaga taaagagctt gccctcgttc agcttgttgg gcttttcgtg 240
ctccatgaat tccacgatcc ggttgtctac ggcgtccacg aaccggcgcc attgctgccc 300
ggcgacctcc atcgtgccta cgctgctggc gcgcctcttt cgctcgagct gctcgctagc 360
actaggccct gtgatctgcc cagtcctcgt gatagattcc ggttttgccg gctggccgtc 420
accaggcggt cccggccatc atcagccagg tttgtcaccc cgaggtaaac gacgcgtgtt 480
caagggcgaa ttcgtttaaa cctgcaggac tagtccctt                        519

<210> 12
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic forward primer

<400> 12
gctgatgatg gccgggacc                                              19

<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic reverse primer

<400> 13
ggtccactcg aattcgtagc g                                           21

<210> 14
<211> 1119
<212> DNA
<213> Artificial Sequence

<220> 
<223> ONCT-18Elo clone synthesized from recombinant
      plasmid

<220> 
<221> CDS            
<222> (135)...(965)

<400> 14
gctgatgatg gccgggaccg cctggtgacg gccagccggc aaaaccggaa tctatcacga 60
ggactgggca gatcacaggg cctagtgcta gcgagcagct cgagcgaaag aggcgcgcca 120
gcagcgtagg cacg atg gag gtc gcc ggg cag caa tgg cgc cgg ttc gtg   170
                Met Glu Val Ala Gly Gln Gln Trp Arg Arg Phe Val
                 1               5                   10
 
gac gcc gta gac aac cgg atc gtg gaa ttc atg gag cac gaa aag ccc   218
Asp Ala Val Asp Asn Arg Ile Val Glu Phe Met Glu His Glu Lys Pro
         15                  20                  25
 
aac aag ctg aac gag ggc aag ctc ttt atc tcg acc gag gag atg atg   266
Asn Lys Leu Asn Glu Gly Lys Leu Phe Ile Ser Thr Glu Glu Met Met
     30                  35                  40
 
gcg ctc atc gtc ggc tac ctg gcg ttc gtg gtt ctc ggg tct gcc ttc   314
Ala Leu Ile Val Gly Tyr Leu Ala Phe Val Val Leu Gly Ser Ala Phe
 45                  50                  55                  60
 
atg acg gcc ttt gtg agt aag cct ttc gag ctc aag ttc ctg aag ctc   362
Met Thr Ala Phe Val Ser Lys Pro Phe Glu Leu Lys Phe Leu Lys Leu
                 65                  70                  75
 
gtg cac aac atc ttt ctc acc ggt ctg tcc ctg tac atg gct agc gag   410
Val His Asn Ile Phe Leu Thr Gly Leu Ser Leu Tyr Met Ala Ser Glu
             80                  85                  90
 
tgc gcg cgc cag gcc tac ctc ggc ggc tac aag ctc ttt ggc aac ccg   458
Cys Ala Arg Gln Ala Tyr Leu Gly Gly Tyr Lys Leu Phe Gly Asn Pro
         95                 100                 105
 
atg gag aag ggt gcc gag tct cac gcc cta ggc atg gct agc att atc   506
Met Glu Lys Gly Ala Glu Ser His Ala Leu Gly Met Ala Ser Ile Ile
    110                 115                 120
 
tac gtt ttt tac gtg agc aag ttc ctc gag ttt ctt gac acg gtc ttc   554
Tyr Val Phe Tyr Val Ser Lys Phe Leu Glu Phe Leu Asp Thr Val Phe
125                 130                 135                 140
 
atg atc ctc ggc aag aag tgg aag cag ctc agc ttt ctt cac gtc tac   602
Met Ile Leu Gly Lys Lys Trp Lys Gln Leu Ser Phe Leu His Val Tyr
                145                 150                 155
 
cac cac gcg agc atc agc ttc atc tgg ggc att atc gcc cgt ttt gcg   650
His His Ala Ser Ile Ser Phe Ile Trp Gly Ile Ile Ala Arg Phe Ala
            160                 165                 170
 
ccc ggt ggc gac gcg tac ttt tcc acc atc ctc aac agc agc gtg cat   698
Pro Gly Gly Asp Ala Tyr Phe Ser Thr Ile Leu Asn Ser Ser Val His
        175                 180                 185
 
gtc gtg ctc tac ggc tac tac gcc tcg acc acg ctc ggc tac acc ttc   746
Val Val Leu Tyr Gly Tyr Tyr Ala Ser Thr Thr Leu Gly Tyr Thr Phe
    190                 195                 200
 
atg cgc ccg ctg cgc ccg tac att act acc atc cag ctc acg cag ttc   794
Met Arg Pro Leu Arg Pro Tyr Ile Thr Thr Ile Gln Leu Thr Gln Phe
205                 210                 215                 220
 
atg gcc atg gtc gtc cag tcc gtc tat gac tac tac aac cct tgc gac   842
Met Ala Met Val Val Gln Ser Val Tyr Asp Tyr Tyr Asn Pro Cys Asp
                225                 230                 235
 
tac ccg cag ccc ctc gtc aag cta ctc ttc tgg tac atg ctc acc atg   890
Tyr Pro Gln Pro Leu Val Lys Leu Leu Phe Trp Tyr Met Leu Thr Met
            240                 245                 250
 
ctc ggc ctc ttc ggc aac ttc ttc gtg cag cag tac ctc aag ccc aag   938
Leu Gly Leu Phe Gly Asn Phe Phe Val Gln Gln Tyr Leu Lys Pro Lys
        255                 260                 265
 
gcg cct aag aag caa aag acc atc tga gccgagtccc atcccaaaat         985
Ala Pro Lys Lys Gln Lys Thr Ile  *
    270                 275
 
acgtcacgca agtgcgtact agtgggagtg aggggctgca agtactactt attggtcacc 1045
gggtaagacc gctagaccgc aacttgtctt gaagcataga ttgttgattc tgtcgctacg 1105
aattcgagtg gacc                                                   1119

<210> 15
<211> 276
<212> PRT
<213> Artificial Sequence

<220> 
<223> synthetic ONCT18_d5elongase peptide

<400> 15
Met Glu Val Ala Gly Gln Gln Trp Arg Arg Phe Val Asp Ala Val Asp
 1               5                  10                  15      
Asn Arg Ile Val Glu Phe Met Glu His Glu Lys Pro Asn Lys Leu Asn
            20                  25                  30          
Glu Gly Lys Leu Phe Ile Ser Thr Glu Glu Met Met Ala Leu Ile Val
        35                  40                  45              
Gly Tyr Leu Ala Phe Val Val Leu Gly Ser Ala Phe Met Thr Ala Phe
    50                  55                  60                  
Val Ser Lys Pro Phe Glu Leu Lys Phe Leu Lys Leu Val His Asn Ile
65                  70                  75                  80  
Phe Leu Thr Gly Leu Ser Leu Tyr Met Ala Ser Glu Cys Ala Arg Gln
                85                  90                  95      
Ala Tyr Leu Gly Gly Tyr Lys Leu Phe Gly Asn Pro Met Glu Lys Gly
            100                 105                 110         
Ala Glu Ser His Ala Leu Gly Met Ala Ser Ile Ile Tyr Val Phe Tyr
        115                 120                 125             
Val Ser Lys Phe Leu Glu Phe Leu Asp Thr Val Phe Met Ile Leu Gly
    130                 135                 140                 
Lys Lys Trp Lys Gln Leu Ser Phe Leu His Val Tyr His His Ala Ser
145                 150                 155                 160 
Ile Ser Phe Ile Trp Gly Ile Ile Ala Arg Phe Ala Pro Gly Gly Asp
                165                 170                 175     
Ala Tyr Phe Ser Thr Ile Leu Asn Ser Ser Val His Val Val Leu Tyr
            180                 185                 190         
Gly Tyr Tyr Ala Ser Thr Thr Leu Gly Tyr Thr Phe Met Arg Pro Leu
        195                 200                 205             
Arg Pro Tyr Ile Thr Thr Ile Gln Leu Thr Gln Phe Met Ala Met Val
    210                 215                 220                 
Val Gln Ser Val Tyr Asp Tyr Tyr Asn Pro Cys Asp Tyr Pro Gln Pro
225                 230                 235                 240 
Leu Val Lys Leu Leu Phe Trp Tyr Met Leu Thr Met Leu Gly Leu Phe
                245                 250                 255     
Gly Asn Phe Phe Val Gln Gln Tyr Leu Lys Pro Lys Ala Pro Lys Lys
            260                 265                 270         
Gln Lys Thr Ile
        275     


<210> 16
<211> 967
<212> DNA
<213> Artificial Sequence

<220> 
<223> 10-3 4DES clone synthesized from recombinant
      plasmid

<400> 16
tacagggtga tgcgcgagcg cgtcgtggcc cggctcaggg agcgcggcaa ggcccgccgc 60
ggtggctatg agctctggac taaggcattt ctgctcctcg tgggtttctg gagctcgttg 120
tactggatgt gcacgctgga cccctcgttc ggggccatct tggccgccat gtcgctgggc 180
gtctttgccg ccttcgtggg cacgtgtatc cagcacgacg gcaaccatgg cgcttttgcc 240
cagtcgcgat gggtcaacaa ggttgccggg tggacgcttg acatgattgg cgccagtggc 300
atgacgtggg agttccagca cgtcctgggc caccacccgt acacgaacct gattgaggag 360
gaaaatggcc tgcaaaaggt gagcggcaag aaaatggaca ccaaggtggc cgaccaggag 420
agcgacccgg atgtcttctc cacgtaccca atgatgcgct tgcacccgtg gcacgaaaag 480
cgctggtacc accgtttcca acacatttac ggcccgttca tcttcggctt catgaccatc 540
aacaaggtag tcacgcagga cgtcgaggtg gtgctccaca agcggctctt ccagattgac 600
gccgagtgcc ggtacgcgag tccgatgtac gtggcgcggt tctggatcat gaaggcgctc 660
acggtgctct acatggtggg cctgccttgc tattcgcagg gcccgtggca cggcctcaag 720
ctgttcgcga tcgcgcactt ttcgtgcggc gaggtgctgg cgaccatgtt cattgtgaat 780
cacatcatcg agggtgtctc ttacgcttcc aaggacgcgg tcaagggcac gatggcgcct 840
ccgaagacga tgcacggcgt gacgcccatg aacaacacgc gcaaggaggc ggaggcgcag 900
gcgtccagtc tggcgctgta gtcaagtcag tccgctcgac gactgggccg ctgtcagtgc 960
cagactt                                                           967

<210> 17
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic primer

<400> 17
ttacgcttcc aaggacgcgg tc                                          22

<210> 18
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic primer

<400> 18
atgaacaaca cgcgcaagga gg                                          22

<210> 19
<211> 782
<212> DNA
<213> Artificial Sequence

<220> 
<223> 3'D2-92 clone synthesized from recombinant plasmid

<400> 19
atgaacaaca cgcgcaagga ggcggaggcg caggcgtcca agtccggcgc tgtagtcaag 60
tcagtcccgc tcgacgactg ggccgctgtc cagtgccaga cttcggtgaa ttggagcgtc 120
ggctcatggt tctggaacca cttttccggc ggcctcaacc accagatcga gcaccatctg 180
ttccctgggc tcagccacga gacgtactac cacattcagg acgtcgttca gtctacctgc 240
gccgagtacg gagtcccgta ccagcacgaa ccctcgctct ggactgcgta ctggaagatg 300
ctcgagcacc tccgtcagct tggcaatgag gagacccacg agtcctggca gcacactgcc 360
tgatgggctg acgagggcgg gtgcgaccaa tttacagttc cttgatcacg agaggctcca 420
caaccagagc acagcagtgc tgcgccggcg tcaatgttcc gtcaattggg tgaaacgcct 480
ccgggtgcgc ggctgggctc ttgtttgatt gcttgcttgc ttgcatgcga gcttgttaca 540
agaccgagcc acccacagcc cgtccatgca tctggggaac agcttgaagt atgaagtact 600
acgtacccgt ttaagcttta aaaaaaggtc aagtcttatc atgaatgcta atgacgattc 660
gctggcgctc atcagaggca accaatcctc agcaaaaggt ttgcaaaggc caaaaagaag 720
tcagcgctag cgccacatgc ataaatcagg gctgtcaccc cggaggtaaa cgacgcgtgt 780
tc                                                                782

<210> 20
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic primer

<400> 20
ctggatacac gtgcccacga ag                                          22

<210> 21
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic primer

<400> 21
cacatccagt acaacgagct ccagaa                                      26

<210> 22
<211> 946
<212> DNA
<213> Artificial Sequence

<220> 
<223> 5'-217 clone synthesized from recombinant plasmid

<400> 22
cacatccagt acaacgagct ccagaaaccc acgaggagca gaaatgcctt agtccagagc 60
tcatagccac cgcggcgggc cttgccgcgc tccctgagcc gggccacgac gcgctcgcgc 120
atcactttgt aaaagtcgct gttccacgtg tagtacgagg ccgacgggag gcctgaaagc 180
gtccgctttt ccttctcatt tgcgccgcct tggccatccg gcagcttccc gatccggtac 240
ttgcgcagca ccgcgtccga gacgccccgc acatggtacg tctcatacaa cacggtggcc 300
tccttgcctg cggccagaag gattatgtcg ccgcccgggt gcacgctcgc gaacttggtt 360
acatcgtaca cgagcccgtg gatcgcgcac caggcgtcat ccggcttgtt gtgcgcgcgg 420
acctgctcga acgagatctc ctcgtcgtag ccgactgtca tcctgacccc tgcgggcagt 480
cctgcctact tcgatcaaat tccttcgcct acggtcgcgc gctccagcgt cagttccccc 540
tgctcagtga aaggctccaa agcttgcggt tctcaatcgc acccagcgcg tccagcctgg 600
gttttgcgcg ctccggcaag atttactgcc aaggatgacg tcatgcgttt cgttcgttcg 660
tccaagtagt ggcccgatcc ccggcccaag cgcccagctt tgcttgcgag cgaagctccg 720
cgcccgtaca cacgcgctcc tggctgctag cgccatcgcg tggcggggca tcgaccgcat 780
gacgttggcg tcgatcatga agacgtgcgt acgtacgtac ctaatggtct acctcgacgg 840
cgatgttcgg gctttgcagc aggatgctca ccccggaggt aaacgacgcg tgttcatctg 900
aattcgtcga caagcttctc gagcctaggc tagctctaga ccacac                946

<210> 23
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic ONC-T184des380F primer

<400> 23
cgattgagaa ccgcaagctt t                                           21

<210> 24
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> synthetic ONC-T184des1687R primer

<400> 24
gcagcactgc tgtgctctgg t                                           21

<210> 25
<211> 1758
<212> DNA
<213> Artificial Sequence

<220> 
<223> complete Phusion PCR T18_d4desat clone synthesized
      from recombinant plasmid

<220> 
<221> CDS            
<222> (119)...(1678)

<400> 25
cgattgagaa ccgcaagctt tggagccttt cactgagcag ggggaactga cgctggagcg 60
cgcgaccgta ggcgaaggaa tttgatcgaa gtaggcagga ctgcctgcag gggtcaag   118
atg aca gtc ggc tac gac gag gag atc tcg ttc gag cag gtc cgc gcg   166
Met Thr Val Gly Tyr Asp Glu Glu Ile Ser Phe Glu Gln Val Arg Ala
 1               5                   10                  15
 
cac aac aag ccg gat gac gcc tgg tgc gcg atc cac ggg ctc gtg tac   214
His Asn Lys Pro Asp Asp Ala Trp Cys Ala Ile His Gly Leu Val Tyr
             20                  25                  30
 
gat gta acc aag ttc gcg agc gtg cac ccg ggc ggc gac ata atc ctt   262
Asp Val Thr Lys Phe Ala Ser Val His Pro Gly Gly Asp Ile Ile Leu
         35                  40                  45
 
ctg gcc gca ggc aag gag gcc acc gtg ttg tat gag acg tac cat gtg   310
Leu Ala Ala Gly Lys Glu Ala Thr Val Leu Tyr Glu Thr Tyr His Val
     50                  55                  60
 
cgg ggc gtc tcg gac gcg gtg ctg cgc aag tac cgg atc ggg aag ctg   358
Arg Gly Val Ser Asp Ala Val Leu Arg Lys Tyr Arg Ile Gly Lys Leu
 65                  70                  75                  80
 
ccg gat ggc caa ggc ggc gca aat gag aag gaa aag cgg acg ctt tca   406
Pro Asp Gly Gln Gly Gly Ala Asn Glu Lys Glu Lys Arg Thr Leu Ser
                 85                  90                  95
 
ggc ctc tcg tcg gcc tcg tac tac acg tgg aac agc gac ttt tac aaa   454
Gly Leu Ser Ser Ala Ser Tyr Tyr Thr Trp Asn Ser Asp Phe Tyr Lys
            100                 105                 110
 
gtg atg cgc gag cgc gtc gtg gcc cgg ctc agg gag cgc ggc aag gcc   502
Val Met Arg Glu Arg Val Val Ala Arg Leu Arg Glu Arg Gly Lys Ala
        115                 120                 125
 
cgc cgc ggt ggc tat gag ctc tgg act aag gca ttt ctg ctc ctc gtg   550
Arg Arg Gly Gly Tyr Glu Leu Trp Thr Lys Ala Phe Leu Leu Leu Val
    130                 135                 140
 
ggt ttc tgg agc tcg ttg tac tgg atg tgc acg ctg gac ccc tcg ttc   598
Gly Phe Trp Ser Ser Leu Tyr Trp Met Cys Thr Leu Asp Pro Ser Phe
145                 150                 155                 160
 
ggg gcc atc ttg gcc gcc atg tcg ctg ggc gtc ttt gcc gcc ttt gtg   646
Gly Ala Ile Leu Ala Ala Met Ser Leu Gly Val Phe Ala Ala Phe Val
                165                 170                 175
 
ggc acg tgt atc cag cac gac ggc aac cat ggc gct ttt gcc cag tcg   694
Gly Thr Cys Ile Gln His Asp Gly Asn His Gly Ala Phe Ala Gln Ser
            180                 185                 190
 
cga tgg gtc aac aag gtt gcc ggg tgg acg ctt gac atg att ggc gcc   742
Arg Trp Val Asn Lys Val Ala Gly Trp Thr Leu Asp Met Ile Gly Ala
        195                 200                 205
 
agt ggc atg acg tgg gag ttc cag cac gtc ctg ggc cac cac ccg tac   790
Ser Gly Met Thr Trp Glu Phe Gln His Val Leu Gly His His Pro Tyr
    210                 215                 220
 
acg aac ctg att gag gag gaa aat ggc ctg caa aag gtg agc ggc aag   838
Thr Asn Leu Ile Glu Glu Glu Asn Gly Leu Gln Lys Val Ser Gly Lys
225                 230                 235                 240
 
aaa atg gac acc aag gtg gcc gac cag gag agc gac ccg gat gtc ttc   886
Lys Met Asp Thr Lys Val Ala Asp Gln Glu Ser Asp Pro Asp Val Phe
                245                 250                 255
 
tcc acg tac cca atg atg cgc ttg cac ccg tgg cac gaa aag cgc tgg   934
Ser Thr Tyr Pro Met Met Arg Leu His Pro Trp His Glu Lys Arg Trp
            260                 265                 270
 
tac cac cgt ttc caa cac att tac ggc ccg ttc atc ttc ggc ttc atg   982
Tyr His Arg Phe Gln His Ile Tyr Gly Pro Phe Ile Phe Gly Phe Met
        275                 280                 285
 
acc atc aac aag gta gtc acg cag gac gtc gag gtg gtg ctc cac aag   1030
Thr Ile Asn Lys Val Val Thr Gln Asp Val Glu Val Val Leu His Lys
    290                 295                 300
 
cgg ctc ttc cag att gac gcc gag tgc cgg tac gcg agt ccg atg tac   1078
Arg Leu Phe Gln Ile Asp Ala Glu Cys Arg Tyr Ala Ser Pro Met Tyr
305                 310                 315                 320
 
gtg gcg cgg ttc tgg atc atg aag gcg ctc acg gtg ctc tac atg gtg   1126
Val Ala Arg Phe Trp Ile Met Lys Ala Leu Thr Val Leu Tyr Met Val
                325                 330                 335
 
ggc ctg cct tgc tat tcg cag ggc ccg tgg cac ggc ctc aag ctg ttc   1174
Gly Leu Pro Cys Tyr Ser Gln Gly Pro Trp His Gly Leu Lys Leu Phe
            340                 345                 350
 
gcg atc gcg cac ttt tcg tgc ggc gag gtg ctg gcg acc atg ttc att   1222
Ala Ile Ala His Phe Ser Cys Gly Glu Val Leu Ala Thr Met Phe Ile
        355                 360                 365
 
gtg aat cac atc atc gag ggt gtc tct tac gct tcc aag gac gcg gtc   1270
Val Asn His Ile Ile Glu Gly Val Ser Tyr Ala Ser Lys Asp Ala Val
    370                 375                 380
 
aag ggc acg atg gcg cct ccg aag acg atg cac ggc gtg acg ccc atg   1318
Lys Gly Thr Met Ala Pro Pro Lys Thr Met His Gly Val Thr Pro Met
385                 390                 395                 400
 
aac aac acg cgc aag gag gcg gag gcg cag gcg tcc aag tct ggc gct   1366
Asn Asn Thr Arg Lys Glu Ala Glu Ala Gln Ala Ser Lys Ser Gly Ala
                405                 410                 415
 
gta gtc aag tca gtc ccg ctc gac gac tgg gcc gct gtc cag tgc cag   1414
Val Val Lys Ser Val Pro Leu Asp Asp Trp Ala Ala Val Gln Cys Gln
            420                 425                 430
 
act tcg gtg aat tgg agc gtc ggc tca tgg ttc tgg aac cac ttt tcc   1462
Thr Ser Val Asn Trp Ser Val Gly Ser Trp Phe Trp Asn His Phe Ser
        435                 440                 445
 
ggc ggc ctc aac cac cag atc gag cac cat ctg ttc cct ggg ctc agc   1510
Gly Gly Leu Asn His Gln Ile Glu His His Leu Phe Pro Gly Leu Ser
    450                 455                 460
 
cac gag acg tac tac cac att cag gac gtc gtt cag tct acc tgc gcc   1558
His Glu Thr Tyr Tyr His Ile Gln Asp Val Val Gln Ser Thr Cys Ala
465                 470                 475                 480
 
gag tac gga gtc ccg tac cag cac gaa ccc tcg ctc tgg act gcg tac   1606
Glu Tyr Gly Val Pro Tyr Gln His Glu Pro Ser Leu Trp Thr Ala Tyr
                485                 490                 495
 
tgg aag atg ctc gag cac ctc cgt cag ctt ggc aat gag gag acc cac   1654
Trp Lys Met Leu Glu His Leu Arg Gln Leu Gly Asn Glu Glu Thr His
            500                 505                 510
 
gag tcc tgg cag cac act gcc tga tgggctgaca agggcgggtg cgaccaattt  1708
Glu Ser Trp Gln His Thr Ala  *
        515
 
acagttcctt gatcacgaga ggctccacaa ccagagcaca gcagtgctgc            1758

<210> 26
<211> 519
<212> PRT
<213> Artificial Sequence

<220> 
<223> syntheticT18_d4desat peptide

<400> 26
Met Thr Val Gly Tyr Asp Glu Glu Ile Ser Phe Glu Gln Val Arg Ala
 1               5                  10                  15      
His Asn Lys Pro Asp Asp Ala Trp Cys Ala Ile His Gly Leu Val Tyr
            20                  25                  30          
Asp Val Thr Lys Phe Ala Ser Val His Pro Gly Gly Asp Ile Ile Leu
        35                  40                  45              
Leu Ala Ala Gly Lys Glu Ala Thr Val Leu Tyr Glu Thr Tyr His Val
    50                  55                  60                  
Arg Gly Val Ser Asp Ala Val Leu Arg Lys Tyr Arg Ile Gly Lys Leu
65                  70                  75                  80  
Pro Asp Gly Gln Gly Gly Ala Asn Glu Lys Glu Lys Arg Thr Leu Ser
                85                  90                  95      
Gly Leu Ser Ser Ala Ser Tyr Tyr Thr Trp Asn Ser Asp Phe Tyr Lys
            100                 105                 110         
Val Met Arg Glu Arg Val Val Ala Arg Leu Arg Glu Arg Gly Lys Ala
        115                 120                 125             
Arg Arg Gly Gly Tyr Glu Leu Trp Thr Lys Ala Phe Leu Leu Leu Val
    130                 135                 140                 
Gly Phe Trp Ser Ser Leu Tyr Trp Met Cys Thr Leu Asp Pro Ser Phe
145                 150                 155                 160 
Gly Ala Ile Leu Ala Ala Met Ser Leu Gly Val Phe Ala Ala Phe Val
                165                 170                 175     
Gly Thr Cys Ile Gln His Asp Gly Asn His Gly Ala Phe Ala Gln Ser
            180                 185                 190         
Arg Trp Val Asn Lys Val Ala Gly Trp Thr Leu Asp Met Ile Gly Ala
        195                 200                 205             
Ser Gly Met Thr Trp Glu Phe Gln His Val Leu Gly His His Pro Tyr
    210                 215                 220                 
Thr Asn Leu Ile Glu Glu Glu Asn Gly Leu Gln Lys Val Ser Gly Lys
225                 230                 235                 240 
Lys Met Asp Thr Lys Val Ala Asp Gln Glu Ser Asp Pro Asp Val Phe
                245                 250                 255     
Ser Thr Tyr Pro Met Met Arg Leu His Pro Trp His Glu Lys Arg Trp
            260                 265                 270         
Tyr His Arg Phe Gln His Ile Tyr Gly Pro Phe Ile Phe Gly Phe Met
        275                 280                 285             
Thr Ile Asn Lys Val Val Thr Gln Asp Val Glu Val Val Leu His Lys
    290                 295                 300                 
Arg Leu Phe Gln Ile Asp Ala Glu Cys Arg Tyr Ala Ser Pro Met Tyr
305                 310                 315                 320 
Val Ala Arg Phe Trp Ile Met Lys Ala Leu Thr Val Leu Tyr Met Val
                325                 330                 335     
Gly Leu Pro Cys Tyr Ser Gln Gly Pro Trp His Gly Leu Lys Leu Phe
            340                 345                 350         
Ala Ile Ala His Phe Ser Cys Gly Glu Val Leu Ala Thr Met Phe Ile
        355                 360                 365             
Val Asn His Ile Ile Glu Gly Val Ser Tyr Ala Ser Lys Asp Ala Val
    370                 375                 380                 
Lys Gly Thr Met Ala Pro Pro Lys Thr Met His Gly Val Thr Pro Met
385                 390                 395                 400 
Asn Asn Thr Arg Lys Glu Ala Glu Ala Gln Ala Ser Lys Ser Gly Ala
                405                 410                 415     
Val Val Lys Ser Val Pro Leu Asp Asp Trp Ala Ala Val Gln Cys Gln
            420                 425                 430         
Thr Ser Val Asn Trp Ser Val Gly Ser Trp Phe Trp Asn His Phe Ser
        435                 440                 445             
Gly Gly Leu Asn His Gln Ile Glu His His Leu Phe Pro Gly Leu Ser
    450                 455                 460                 
His Glu Thr Tyr Tyr His Ile Gln Asp Val Val Gln Ser Thr Cys Ala
465                 470                 475                 480 
Glu Tyr Gly Val Pro Tyr Gln His Glu Pro Ser Leu Trp Thr Ala Tyr
                485                 490                 495     
Trp Lys Met Leu Glu His Leu Arg Gln Leu Gly Asn Glu Glu Thr His
            500                 505                 510         
Glu Ser Trp Gln His Thr Ala
        515                 

