                              Sequence Listing

<110> GENENTECH, INC.
      DESNOYERS, LUC

<120> KLOTHO BETA

<130> P2477R1 WO


<150> US 60/909,699
<151> 2007-04-02

<150> US 60/916,187
<151> 2007-05-04

<160> 58

<210> 1
<211> 3132
<212> DNA
<213> Homo sapiens

<400> 1
 atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt 50

 cagcactgat gaaataacca cacgctatag gaatacaatg tccaacgggg 100

 gattgcaaag atctgtcatc ctgtcagcac ttattctgct acgagctgtt 150

 actggattct ctggagatgg aagagctata tggtctaaaa atcctaattt 200

 tactccggta aatgaaagtc agctgtttct ctatgacact ttccctaaaa 250

 actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg 300

 aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca 350

 ccttaaaaat gtcagcagca cgaatggttc cagtgacagt tatatttttc 400

 tggaaaaaga cttatcagcc ctggatttta taggagtttc tttttatcaa 450

 ttttcaattt cctggccaag gcttttcccc gatggaatag taacagttgc 500

 caacgcaaaa ggtctgcagt actacagtac tcttctggac gctctagtgc 550

 ttagaaacat tgaacctata gttactttat accactggga tttgcctttg 600

 gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat 650

 cttcaatgac tatgccacat actgtttcca gatgtttggg gaccgtgtca 700

 aatattggat tacaattcac aacccatatc tagtggcttg gcatgggtat 750

 gggacaggta tgcatgcccc tggagagaag ggaaatttag cagctgtcta 800

 cactgtggga cacaacttga tcaaggctca ctcgaaagtt tggcataact 850

 acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg 900

 ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt 950

 caaatgtcaa caatccatgg tttctgtgct tggatggttt gccaacccta 1000

 tccatgggga tggcgactat ccagagggga tgagaaagaa gttgttctcc 1050

 gttctaccca ttttctctga agcagagaag catgagatga gaggcacagc 1100

 tgatttcttt gccttttctt ttggacccaa caacttcaag cccctaaaca 1150

 ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg 1200

 aactggatta aactggaata caacaaccct cgaatcttga ttgctgcgaa 1250

 tggctggttc acagacagtc gtgtgaaaac agaagacacc acggccatct 1300

 acatgatgaa gaatttcctc agccaggtgc ttcaagcaat aaggttagat 1350

 gaaatacgag tgtttggtta tactgcctgg tctctcctgg atggctttga 1400

 atggcaggat gcttacacca tccgccgagg attattttat gtggatttta 1450

 acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa 1500

 cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt 1550

 gcagggccag tttccctgtg acttctcctg gggtgtcact gaatctgttc 1600

 ttaagcccga gtctgtggct tcgtccccac agttcagcga tcctcatctg 1650

 tacgtgtgga acgccactgg caacagactg ttgcaccgag tggaaggggt 1700

 gaggctgaaa acacgacccg ctcaatgcac agattttgta aacatcaaaa 1750

 aacaacttga gatgttggca agaatgaaag tcacccacta ccggtttgct 1800

 ctggattggg cctcggtcct tcccactggc aacctgtccg cggtgaaccg 1850

 acaggccctg aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg 1900

 gcatctccgc gatggtcacc ctgtattatc cgacccacgc ccacctaggc 1950

 ctccccgagc ctctgttgca tgccgacggg tggctgaacc catcgacggc 2000

 cgaggccttc caggcctacg ctgggctgtg cttccaggag ctgggggacc 2050

 tggtgaagct ctggatcacc atcaacgcgc ctaaccggct aagtgacatc 2100

 tacaaccgct ctggcaacga cacctacggg gcggcgcaca acctgctggt 2150

 ggcccacgcc ctggcctggc gcctctacga ccggcagttc aggccctcac 2200

 agcgcggggc cgtgtcgctg tcgctgcacg cggactgggc ggaacccgcc 2250

 aacccctatg ctgactcgca ctggagggcg gccgagcgct tcctgcagtt 2300

 cgagatcgcc tggttcgccg agccgctctt caagaccggg gactaccccg 2350

 cggccatgag ggaatacatt gcctccaagc accgacgggg gctttccagc 2400

 tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc tcaagggcac 2450

 ggtcgacttc tgcgcgctca accacttcac cactaggttc gtgatgcacg 2500

 agcagctggc cggcagccgc tacgactcgg acagggacat ccagtttctg 2550

 caggacatca cccgcctgag ctcccccacg cgcctggctg tgattccctg 2600

 gggggtgcgc aagctgctgc ggtgggtccg gaggaactac ggcgacatgg 2650

 acatttacat caccgccagt ggcatcgacg accaggctct ggaggatgac 2700

 cggctccgga agtactacct agggaagtac cttcaggagg tgctgaaagc 2750

 atacctgatt gataaagtca gaatcaaagg ctattatgca ttcaaactgg 2800

 ctgaagagaa atctaaaccc agatttggat tcttcacatc tgattttaaa 2850

 gctaaatcct caatacaatt ttacaacaaa gtgatcagca gcaggggctt 2900

 cccttttgag aacagtagtt ctagatgcag tcagacccaa gaaaatacag 2950

 agtgcactgt ctgcttattc cttgtgcaga agaaaccact gatattcctg 3000

 ggttgttgct tcttctccac cctggttcta ctcttatcaa ttgccatttt 3050

 tcaaaggcag aagagaagaa agttttggaa agcaaaaaac ttacaacaca 3100

 taccattaaa gaaaggcaag agagttgtta  gc 3132

<210> 2
<211> 1044
<212> PRT
<213> Humanized

<400> 2
 Met Lys Pro Gly Cys Ala Ala Gly Ser Pro Gly Asn Glu Trp Ile
   1               5                  10                  15

 Phe Phe Ser Thr Asp Glu Ile Thr Thr Arg Tyr Arg Asn Thr Met
                  20                  25                  30

 Ser Asn Gly Gly Leu Gln Arg Ser Val Ile Leu Ser Ala Leu Ile
                  35                  40                  45

 Leu Leu Arg Ala Val Thr Gly Phe Ser Gly Asp Gly Arg Ala Ile
                  50                  55                  60

 Trp Ser Lys Asn Pro Asn Phe Thr Pro Val Asn Glu Ser Gln Leu
                  65                  70                  75

 Phe Leu Tyr Asp Thr Phe Pro Lys Asn Phe Phe Trp Gly Ile Gly
                  80                  85                  90

 Thr Gly Ala Leu Gln Val Glu Gly Ser Trp Lys Lys Asp Gly Lys
                  95                 100                 105

 Gly Pro Ser Ile Trp Asp His Phe Ile His Thr His Leu Lys Asn
                 110                 115                 120

 Val Ser Ser Thr Asn Gly Ser Ser Asp Ser Tyr Ile Phe Leu Glu
                 125                 130                 135

 Lys Asp Leu Ser Ala Leu Asp Phe Ile Gly Val Ser Phe Tyr Gln
                 140                 145                 150

 Phe Ser Ile Ser Trp Pro Arg Leu Phe Pro Asp Gly Ile Val Thr
                 155                 160                 165

 Val Ala Asn Ala Lys Gly Leu Gln Tyr Tyr Ser Thr Leu Leu Asp
                 170                 175                 180

 Ala Leu Val Leu Arg Asn Ile Glu Pro Ile Val Thr Leu Tyr His
                 185                 190                 195

 Trp Asp Leu Pro Leu Ala Leu Gln Glu Lys Tyr Gly Gly Trp Lys
                 200                 205                 210

 Asn Asp Thr Ile Ile Asp Ile Phe Asn Asp Tyr Ala Thr Tyr Cys
                 215                 220                 225

 Phe Gln Met Phe Gly Asp Arg Val Lys Tyr Trp Ile Thr Ile His
                 230                 235                 240

 Asn Pro Tyr Leu Val Ala Trp His Gly Tyr Gly Thr Gly Met His
                 245                 250                 255

 Ala Pro Gly Glu Lys Gly Asn Leu Ala Ala Val Tyr Thr Val Gly
                 260                 265                 270

 His Asn Leu Ile Lys Ala His Ser Lys Val Trp His Asn Tyr Asn
                 275                 280                 285

 Thr His Phe Arg Pro His Gln Lys Gly Trp Leu Ser Ile Thr Leu
                 290                 295                 300

 Gly Ser His Trp Ile Glu Pro Asn Arg Ser Glu Asn Thr Met Asp
                 305                 310                 315

 Ile Phe Lys Cys Gln Gln Ser Met Val Ser Val Leu Gly Trp Phe
                 320                 325                 330

 Ala Asn Pro Ile His Gly Asp Gly Asp Tyr Pro Glu Gly Met Arg
                 335                 340                 345

 Lys Lys Leu Phe Ser Val Leu Pro Ile Phe Ser Glu Ala Glu Lys
                 350                 355                 360

 His Glu Met Arg Gly Thr Ala Asp Phe Phe Ala Phe Ser Phe Gly
                 365                 370                 375

 Pro Asn Asn Phe Lys Pro Leu Asn Thr Met Ala Lys Met Gly Gln
                 380                 385                 390

 Asn Val Ser Leu Asn Leu Arg Glu Ala Leu Asn Trp Ile Lys Leu
                 395                 400                 405

 Glu Tyr Asn Asn Pro Arg Ile Leu Ile Ala Ala Asn Gly Trp Phe
                 410                 415                 420

 Thr Asp Ser Arg Val Lys Thr Glu Asp Thr Thr Ala Ile Tyr Met
                 425                 430                 435

 Met Lys Asn Phe Leu Ser Gln Val Leu Gln Ala Ile Arg Leu Asp
                 440                 445                 450

 Glu Ile Arg Val Phe Gly Tyr Thr Ala Trp Ser Leu Leu Asp Gly
                 455                 460                 465

 Phe Glu Trp Gln Asp Ala Tyr Thr Ile Arg Arg Gly Leu Phe Tyr
                 470                 475                 480

 Val Asp Phe Asn Ser Lys Gln Lys Glu Arg Lys Pro Lys Ser Ser
                 485                 490                 495

 Ala His Tyr Tyr Lys Gln Ile Ile Arg Glu Asn Gly Phe Ser Leu
                 500                 505                 510

 Lys Glu Ser Thr Pro Asp Val Gln Gly Gln Phe Pro Cys Asp Phe
                 515                 520                 525

 Ser Trp Gly Val Thr Glu Ser Val Leu Lys Pro Glu Ser Val Ala
                 530                 535                 540

 Ser Ser Pro Gln Phe Ser Asp Pro His Leu Tyr Val Trp Asn Ala
                 545                 550                 555

 Thr Gly Asn Arg Leu Leu His Arg Val Glu Gly Val Arg Leu Lys
                 560                 565                 570

 Thr Arg Pro Ala Gln Cys Thr Asp Phe Val Asn Ile Lys Lys Gln
                 575                 580                 585

 Leu Glu Met Leu Ala Arg Met Lys Val Thr His Tyr Arg Phe Ala
                 590                 595                 600

 Leu Asp Trp Ala Ser Val Leu Pro Thr Gly Asn Leu Ser Ala Val
                 605                 610                 615

 Asn Arg Gln Ala Leu Arg Tyr Tyr Arg Cys Val Val Ser Glu Gly
                 620                 625                 630

 Leu Lys Leu Gly Ile Ser Ala Met Val Thr Leu Tyr Tyr Pro Thr
                 635                 640                 645

 His Ala His Leu Gly Leu Pro Glu Pro Leu Leu His Ala Asp Gly
                 650                 655                 660

 Trp Leu Asn Pro Ser Thr Ala Glu Ala Phe Gln Ala Tyr Ala Gly
                 665                 670                 675

 Leu Cys Phe Gln Glu Leu Gly Asp Leu Val Lys Leu Trp Ile Thr
                 680                 685                 690

 Ile Asn Ala Pro Asn Arg Leu Ser Asp Ile Tyr Asn Arg Ser Gly
                 695                 700                 705

 Asn Asp Thr Tyr Gly Ala Ala His Asn Leu Leu Val Ala His Ala
                 710                 715                 720

 Leu Ala Trp Arg Leu Tyr Asp Arg Gln Phe Arg Pro Ser Gln Arg
                 725                 730                 735

 Gly Ala Val Ser Leu Ser Leu His Ala Asp Trp Ala Glu Pro Ala
                 740                 745                 750

 Asn Pro Tyr Ala Asp Ser His Trp Arg Ala Ala Glu Arg Phe Leu
                 755                 760                 765

 Gln Phe Glu Ile Ala Trp Phe Ala Glu Pro Leu Phe Lys Thr Gly
                 770                 775                 780

 Asp Tyr Pro Ala Ala Met Arg Glu Tyr Ile Ala Ser Lys His Arg
                 785                 790                 795

 Arg Gly Leu Ser Ser Ser Ala Leu Pro Arg Leu Thr Glu Ala Glu
                 800                 805                 810

 Arg Arg Leu Leu Lys Gly Thr Val Asp Phe Cys Ala Leu Asn His
                 815                 820                 825

 Phe Thr Thr Arg Phe Val Met His Glu Gln Leu Ala Gly Ser Arg
                 830                 835                 840

 Tyr Asp Ser Asp Arg Asp Ile Gln Phe Leu Gln Asp Ile Thr Arg
                 845                 850                 855

 Leu Ser Ser Pro Thr Arg Leu Ala Val Ile Pro Trp Gly Val Arg
                 860                 865                 870

 Lys Leu Leu Arg Trp Val Arg Arg Asn Tyr Gly Asp Met Asp Ile
                 875                 880                 885

 Tyr Ile Thr Ala Ser Gly Ile Asp Asp Gln Ala Leu Glu Asp Asp
                 890                 895                 900

 Arg Leu Arg Lys Tyr Tyr Leu Gly Lys Tyr Leu Gln Glu Val Leu
                 905                 910                 915

 Lys Ala Tyr Leu Ile Asp Lys Val Arg Ile Lys Gly Tyr Tyr Ala
                 920                 925                 930

 Phe Lys Leu Ala Glu Glu Lys Ser Lys Pro Arg Phe Gly Phe Phe
                 935                 940                 945

 Thr Ser Asp Phe Lys Ala Lys Ser Ser Ile Gln Phe Tyr Asn Lys
                 950                 955                 960

 Val Ile Ser Ser Arg Gly Phe Pro Phe Glu Asn Ser Ser Ser Arg
                 965                 970                 975

 Cys Ser Gln Thr Gln Glu Asn Thr Glu Cys Thr Val Cys Leu Phe
                 980                 985                 990

 Leu Val Gln Lys Lys Pro Leu Ile Phe Leu Gly Cys Cys Phe Phe
                 995                1000                1005

 Ser Thr Leu Val Leu Leu Leu Ser Ile Ala Ile Phe Gln Arg Gln
                1010                1015                1020

 Lys Arg Arg Lys Phe Trp Lys Ala Lys Asn Leu Gln His Ile Pro
                1025                1030                1035

 Leu Lys Lys Gly Lys Arg Val Val Ser
                1040                

<210> 3
<211> 34
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 3
 cgggcgctag catgaagcca ggctgtgcgg  cagg 34

<210> 4
<211> 63
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 4
 cagtggatcc ttacttatcg tcgtcatcct tgtaatcgct aacaactctc 50

 ttgcctttct  ttc 63

<210> 5
<211> 37
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 5
 ccgccggata tcatgcggct gctgctggcc  ctgttgg 37

<210> 6
<211> 37
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 6
 ccgccggaat tctgtctgca ccccagaccc  gaagggg 37

<210> 7
<211> 79
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 7
 ggtctggggt gcagacaggt aagcctatcc ctaaccctct cctcggtctc 50

 gattctacgt aggaattcgg  atccgcggc 79

<210> 8
<211> 79
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 8
 gccgcggatc cgaattccta cgtagaatcg agaccgagga gagggttagg 50

 gataggctta cctgtctgca  ccccagacc 79

<210> 9
<211> 41
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 9
 gaattccacc atgaagccag gctgtgcggc aggatctcca  g 41

<210> 10
<211> 37
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 10
 ggcgcgccga caaggaataa gcagacagtg  cactctg 37

<210> 11
<211> 42
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 11
 ccctcgaatc ttgattgctg cgaatggctg gttcacagac  ag 42

<210> 12
<211> 42
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 12
 ctgtctgtga accagccatt cgcagcaatc aagattcgag  gg 42

<210> 13
<211> 40
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 13
 gctctggatc accatcaacg cgcctaaccg gctaagtgac 40

<210> 14
<211> 40
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 14
 gtcacttagc cggttaggcg cgttgatggt gatccagagc 40

<210> 15
<211> 19
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 15
 agcggattct  catggaaca 19

<210> 16
<211> 18
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 16
 ctggtcagcc  aggagctt 18

<210> 17
<211> 24
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 17
 tccacaagct gaaggcagac  aagg 24

<210> 18
<211> 25
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 18
 gcagtcagac ccaagaaaat  acaga 25

<210> 19
<211> 24
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 19
 cccaggaata tcagtggttt  cttc 24

<210> 20
<211> 23
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 20
 tgcactgtct gcttattcct  tgt 23

<210> 21
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 21
 cgagcccttt gatgacttcc  t 21

<210> 22
<211> 18
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 22
 ggagcgggct  gtctcaga 18

<210> 23
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 23
 cccagcatca tccaggccca  g 21

<210> 24
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 24
 agtccttcca cctcgacgtt  t 21

<210> 25
<211> 23
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 25
 aatcgagtct gtttccagca  gaa 23

<210> 26
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 26
 agccccccct tccacttttt 20

<210> 27
<211> 21
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 27
 cgttaacagt gggtgccaac  t 21

<210> 28
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 28
 cccgacggtc tctcttcaaa 20

<210> 29
<211> 24
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 29
 atgctaacgc agcagttgca  aaca 24

<210> 30
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 30
 tgtggtgagc gaaggactga 20

<210> 31
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 31
 ggagtgggtt gggtggtaca 20

<210> 32
<211> 19
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 32
 ctgggcgtct  tccccatgg 19

<210> 33
<211> 18
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 33
 cctgcccctt  ctcaacga 18

<210> 34
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 34
 tccacgttgc tgatgctctt 20

<210> 35
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 35
 ccaagccatc cttggagcca  gt 22

<210> 36
<211> 22
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 36
 cgccagcctg tcactataca  aa 22

<210> 37
<211> 20
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 37
 ccagaggacc tcgactccaa 20

<210> 38
<211> 25
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 38
 cgtttccctt tggcccgaca  gttct 25

<210> 39
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 39
 gcacacuacu acaaacagau  u 21

<210> 40
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 40
 ucuguuugua guagugugcu  u 21

<210> 41
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 41
 gcacgaaugg uuccagugau  u 21

<210> 42
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 42
 ucacuggaac cauucgugcu  u 21

<210> 43
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 43
 cgauggauau auucaaaugu  u 21

<210> 44
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 44
 cauuugaaua uauccaucgu  u 21

<210> 45
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 45
 ugaaauaacc acacgcuauu  u 21

<210> 46
<211> 21
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 46
 auagcgugug guuauuucau  u 21

<210> 47
<211> 19
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 47
 ugguuuacau  guuccaaua 19

<210> 48
<211> 19
<212> RNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 48
 uauuggaaca  uguaaacca 19

<210> 49
<211> 3159
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 49
 atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt 50

 cagcactgat gaaataacca cacgctatag gaatacaatg tccaacgggg 100

 gattgcaaag atctgtcatc ctgtcagcac ttattctgct acgagctgtt 150

 actggattct ctggagatgg aagagctata tggtctaaaa atcctaattt 200

 tactccggta aatgaaagtc agctgtttct ctatgacact ttccctaaaa 250

 actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg 300

 aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca 350

 ccttaaaaat gtcagcagca cgaatggttc cagtgacagt tatatttttc 400

 tggaaaaaga cttatcagcc ctggatttta taggagtttc tttttatcaa 450

 ttttcaattt cctggccaag gcttttcccc gatggaatag taacagttgc 500

 caacgcaaaa ggtctgcagt actacagtac tcttctggac gctctagtgc 550

 ttagaaacat tgaacctata gttactttat accactggga tttgcctttg 600

 gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat 650

 cttcaatgac tatgccacat actgtttcca gatgtttggg gaccgtgtca 700

 aatattggat tacaattcac aacccatatc tagtggcttg gcatgggtat 750

 gggacaggta tgcatgcccc tggagagaag ggaaatttag cagctgtcta 800

 cactgtggga cacaacttga tcaaggctca ctcgaaagtt tggcataact 850

 acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg 900

 ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt 950

 caaatgtcaa caatccatgg tttctgtgct tggatggttt gccaacccta 1000

 tccatgggga tggcgactat ccagagggga tgagaaagaa gttgttctcc 1050

 gttctaccca ttttctctga agcagagaag catgagatga gaggcacagc 1100

 tgatttcttt gccttttctt ttggacccaa caacttcaag cccctaaaca 1150

 ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg 1200

 aactggatta aactggaata caacaaccct cgaatcttga ttgctgagaa 1250

 tggctggttc acagacagtc gtgtgaaaac agaagacacc acggccatct 1300

 acatgatgaa gaatttcctc agccaggtgc ttcaagcaat aaggttagat 1350

 gaaatacgag tgtttggtta tactgcctgg tctctcctgg atggctttga 1400

 atggcaggat gcttacacca tccgccgagg attattttat gtggatttta 1450

 acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa 1500

 cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt 1550

 gcagggccag tttccctgtg acttctcctg gggtgtcact gaatctgttc 1600

 ttaagcccga gtctgtggct tcgtccccac agttcagcga tcctcatctg 1650

 tacgtgtgga acgccactgg caacagactg ttgcaccgag tggaaggggt 1700

 gaggctgaaa acacgacccg ctcaatgcac agattttgta aacatcaaaa 1750

 aacaacttga gatgttggca agaatgaaag tcacccacta ccggtttgct 1800

 ctggattggg cctcggtcct tcccactggc aacctgtccg cggtgaaccg 1850

 acaggccctg aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg 1900

 gcatctccgc gatggtcacc ctgtattatc cgacccacgc ccacctaggc 1950

 ctccccgagc ctctgttgca tgccgacggg tggctgaacc catcgacggc 2000

 cgaggccttc caggcctacg ctgggctgtg cttccaggag ctgggggacc 2050

 tggtgaagct ctggatcacc atcaacgagc ctaaccggct aagtgacatc 2100

 tacaaccgct ctggcaacga cacctacggg gcggcgcaca acctgctggt 2150

 ggcccacgcc ctggcctggc gcctctacga ccggcagttc aggccctcac 2200

 agcgcggggc cgtgtcgctg tcgctgcacg cggactgggc ggaacccgcc 2250

 aacccctatg ctgactcgca ctggagggcg gccgagcgct tcctgcagtt 2300

 cgagatcgcc tggttcgccg agccgctctt caagaccggg gactaccccg 2350

 cggccatgag ggaatacatt gcctccaagc accgacgggg gctttccagc 2400

 tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc tcaagggcac 2450

 ggtcgacttc tgcgcgctca accacttcac cactaggttc gtgatgcacg 2500

 agcagctggc cggcagccgc tacgactcgg acagggacat ccagtttctg 2550

 caggacatca cccgcctgag ctcccccacg cgcctggctg tgattccctg 2600

 gggggtgcgc aagctgctgc ggtgggtccg gaggaactac ggcgacatgg 2650

 acatttacat caccgccagt ggcatcgacg accaggctct ggaggatgac 2700

 cggctccgga agtactacct agggaagtac cttcaggagg tgctgaaagc 2750

 atacctgatt gataaagtca gaatcaaagg ctattatgca ttcaaactgg 2800

 ctgaagagaa atctaaaccc agatttggat tcttcacatc tgattttaaa 2850

 gctaaatcct caatacaatt ttacaacaaa gtgatcagca gcaggggctt 2900

 cccttttgag aacagtagtt ctagatgcag tcagacccaa gaaaatacag 2950

 agtgcactgt ctgcttattc cttgtgcaga agaaaccact gatattcctg 3000

 ggttgttgct tcttctccac cctggttcta ctcttatcaa ttgccatttt 3050

 tcaaaggcag aagagaagaa agttttggaa agcaaaaaac ttacaacaca 3100

 taccattaaa gaaaggcaag agagttgtta gcgattacaa ggatgacgac 3150

 gataagtaa 3159

<210> 50
<211> 3012
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 50
 atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt 50

 cagcactgat gaaataacca cacgctatag gaatacaatg tccaacgggg 100

 gattgcaaag atctgtcatc ctgtcagcac ttattctgct acgagctgtt 150

 actggattct ctggagatgg aagagctata tggtctaaaa atcctaattt 200

 tactccggta aatgaaagtc agctgtttct ctatgacact ttccctaaaa 250

 actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg 300

 aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca 350

 ccttaaaaat gtcagcagca cgaatggttc cagtgacagt tatatttttc 400

 tggaaaaaga cttatcagcc ctggatttta taggagtttc tttttatcaa 450

 ttttcaattt cctggccaag gcttttcccc gatggaatag taacagttgc 500

 caacgcaaaa ggtctgcagt actacagtac tcttctggac gctctagtgc 550

 ttagaaacat tgaacctata gttactttat accactggga tttgcctttg 600

 gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat 650

 cttcaatgac tatgccacat actgtttcca gatgtttggg gaccgtgtca 700

 aatattggat tacaattcac aacccatatc tagtggcttg gcatgggtat 750

 gggacaggta tgcatgcccc tggagagaag ggaaatttag cagctgtcta 800

 cactgtggga cacaacttga tcaaggctca ctcgaaagtt tggcataact 850

 acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg 900

 ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt 950

 caaatgtcaa caatccatgg tttctgtgct tggatggttt gccaacccta 1000

 tccatgggga tggcgactat ccagagggga tgagaaagaa gttgttctcc 1050

 gttctaccca ttttctctga agcagagaag catgagatga gaggcacagc 1100

 tgatttcttt gccttttctt ttggacccaa caacttcaag cccctaaaca 1150

 ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg 1200

 aactggatta aactggaata caacaaccct cgaatcttga ttgctgagaa 1250

 tggctggttc acagacagtc gtgtgaaaac agaagacacc acggccatct 1300

 acatgatgaa gaatttcctc agccaggtgc ttcaagcaat aaggttagat 1350

 gaaatacgag tgtttggtta tactgcctgg tctctcctgg atggctttga 1400

 atggcaggat gcttacacca tccgccgagg attattttat gtggatttta 1450

 acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa 1500

 cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt 1550

 gcagggccag tttccctgtg acttctcctg gggtgtcact gaatctgttc 1600

 ttaagcccga gtctgtggct tcgtccccac agttcagcga tcctcatctg 1650

 tacgtgtgga acgccactgg caacagactg ttgcaccgag tggaaggggt 1700

 gaggctgaaa acacgacccg ctcaatgcac agattttgta aacatcaaaa 1750

 aacaacttga gatgttggca agaatgaaag tcacccacta ccggtttgct 1800

 ctggattggg cctcggtcct tcccactggc aacctgtccg cggtgaaccg 1850

 acaggccctg aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg 1900

 gcatctccgc gatggtcacc ctgtattatc cgacccacgc ccacctaggc 1950

 ctccccgagc ctctgttgca tgccgacggg tggctgaacc catcgacggc 2000

 cgaggccttc caggcctacg ctgggctgtg cttccaggag ctgggggacc 2050

 tggtgaagct ctggatcacc atcaacgagc ctaaccggct aagtgacatc 2100

 tacaaccgct ctggcaacga cacctacggg gcggcgcaca acctgctggt 2150

 ggcccacgcc ctggcctggc gcctctacga ccggcagttc aggccctcac 2200

 agcgcggggc cgtgtcgctg tcgctgcacg cggactgggc ggaacccgcc 2250

 aacccctatg ctgactcgca ctggagggcg gccgagcgct tcctgcagtt 2300

 cgagatcgcc tggttcgccg agccgctctt caagaccggg gactaccccg 2350

 cggccatgag ggaatacatt gcctccaagc accgacgggg gctttccagc 2400

 tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc tcaagggcac 2450

 ggtcgacttc tgcgcgctca accacttcac cactaggttc gtgatgcacg 2500

 agcagctggc cggcagccgc tacgactcgg acagggacat ccagtttctg 2550

 caggacatca cccgcctgag ctcccccacg cgcctggctg tgattccctg 2600

 gggggtgcgc aagctgctgc ggtgggtccg gaggaactac ggcgacatgg 2650

 acatttacat caccgccagt ggcatcgacg accaggctct ggaggatgac 2700

 cggctccgga agtactacct agggaagtac cttcaggagg tgctgaaagc 2750

 atacctgatt gataaagtca gaatcaaagg ctattatgca ttcaaactgg 2800

 ctgaagagaa atctaaaccc agatttggat tcttcacatc tgattttaaa 2850

 gctaaatcct caatacaatt ttacaacaaa gtgatcagca gcaggggctt 2900

 cccttttgag aacagtagtt ctagatgcag tcagacccaa gaaaatacag 2950

 agtgcactgt ctgcttattc cttgtcggcg cgccccatca tcatcatcat 3000

 catcaccact  aa 3012

<210> 51
<211> 3159
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 51
 atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt 50

 cagcactgat gaaataacca cacgctatag gaatacaatg tccaacgggg 100

 gattgcaaag atctgtcatc ctgtcagcac ttattctgct acgagctgtt 150

 actggattct ctggagatgg aagagctata tggtctaaaa atcctaattt 200

 tactccggta aatgaaagtc agctgtttct ctatgacact ttccctaaaa 250

 actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg 300

 aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca 350

 ccttaaaaat gtcagcagca cgaatggttc cagtgacagt tatatttttc 400

 tggaaaaaga cttatcagcc ctggatttta taggagtttc tttttatcaa 450

 ttttcaattt cctggccaag gcttttcccc gatggaatag taacagttgc 500

 caacgcaaaa ggtctgcagt actacagtac tcttctggac gctctagtgc 550

 ttagaaacat tgaacctata gttactttat accactggga tttgcctttg 600

 gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat 650

 cttcaatgac tatgccacat actgtttcca gatgtttggg gaccgtgtca 700

 aatattggat tacaattcac aacccatatc tagtggcttg gcatgggtat 750

 gggacaggta tgcatgcccc tggagagaag ggaaatttag cagctgtcta 800

 cactgtggga cacaacttga tcaaggctca ctcgaaagtt tggcataact 850

 acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg 900

 ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt 950

 caaatgtcaa caatccatgg tttctgtgct tggatggttt gccaacccta 1000

 tccatgggga tggcgactat ccagagggga tgagaaagaa gttgttctcc 1050

 gttctaccca ttttctctga agcagagaag catgagatga gaggcacagc 1100

 tgatttcttt gccttttctt ttggacccaa caacttcaag cccctaaaca 1150

 ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg 1200

 aactggatta aactggaata caacaaccct cgaatcttga ttgctgcgaa 1250

 tggctggttc acagacagtc gtgtgaaaac agaagacacc acggccatct 1300

 acatgatgaa gaatttcctc agccaggtgc ttcaagcaat aaggttagat 1350

 gaaatacgag tgtttggtta tactgcctgg tctctcctgg atggctttga 1400

 atggcaggat gcttacacca tccgccgagg attattttat gtggatttta 1450

 acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa 1500

 cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt 1550

 gcagggccag tttccctgtg acttctcctg gggtgtcact gaatctgttc 1600

 ttaagcccga gtctgtggct tcgtccccac agttcagcga tcctcatctg 1650

 tacgtgtgga acgccactgg caacagactg ttgcaccgag tggaaggggt 1700

 gaggctgaaa acacgacccg ctcaatgcac agattttgta aacatcaaaa 1750

 aacaacttga gatgttggca agaatgaaag tcacccacta ccggtttgct 1800

 ctggattggg cctcggtcct tcccactggc aacctgtccg cggtgaaccg 1850

 acaggccctg aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg 1900

 gcatctccgc gatggtcacc ctgtattatc cgacccacgc ccacctaggc 1950

 ctccccgagc ctctgttgca tgccgacggg tggctgaacc catcgacggc 2000

 cgaggccttc caggcctacg ctgggctgtg cttccaggag ctgggggacc 2050

 tggtgaagct ctggatcacc atcaacgagc ctaaccggct aagtgacatc 2100

 tacaaccgct ctggcaacga cacctacggg gcggcgcaca acctgctggt 2150

 ggcccacgcc ctggcctggc gcctctacga ccggcagttc aggccctcac 2200

 agcgcggggc cgtgtcgctg tcgctgcacg cggactgggc ggaacccgcc 2250

 aacccctatg ctgactcgca ctggagggcg gccgagcgct tcctgcagtt 2300

 cgagatcgcc tggttcgccg agccgctctt caagaccggg gactaccccg 2350

 cggccatgag ggaatacatt gcctccaagc accgacgggg gctttccagc 2400

 tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc tcaagggcac 2450

 ggtcgacttc tgcgcgctca accacttcac cactaggttc gtgatgcacg 2500

 agcagctggc cggcagccgc tacgactcgg acagggacat ccagtttctg 2550

 caggacatca cccgcctgag ctcccccacg cgcctggctg tgattccctg 2600

 gggggtgcgc aagctgctgc ggtgggtccg gaggaactac ggcgacatgg 2650

 acatttacat caccgccagt ggcatcgacg accaggctct ggaggatgac 2700

 cggctccgga agtactacct agggaagtac cttcaggagg tgctgaaagc 2750

 atacctgatt gataaagtca gaatcaaagg ctattatgca ttcaaactgg 2800

 ctgaagagaa atctaaaccc agatttggat tcttcacatc tgattttaaa 2850

 gctaaatcct caatacaatt ttacaacaaa gtgatcagca gcaggggctt 2900

 cccttttgag aacagtagtt ctagatgcag tcagacccaa gaaaatacag 2950

 agtgcactgt ctgcttattc cttgtgcaga agaaaccact gatattcctg 3000

 ggttgttgct tcttctccac cctggttcta ctcttatcaa ttgccatttt 3050

 tcaaaggcag aagagaagaa agttttggaa agcaaaaaac ttacaacaca 3100

 taccattaaa gaaaggcaag agagttgtta gcgattacaa ggatgacgac 3150

 gataagtaa 3159

<210> 52
<211> 3159
<212> DNA
<213> Artificial sequence

<220>
<223> sequence is synthesized

<400> 52
 atgaagccag gctgtgcggc aggatctcca gggaatgaat ggattttctt 50

 cagcactgat gaaataacca cacgctatag gaatacaatg tccaacgggg 100

 gattgcaaag atctgtcatc ctgtcagcac ttattctgct acgagctgtt 150

 actggattct ctggagatgg aagagctata tggtctaaaa atcctaattt 200

 tactccggta aatgaaagtc agctgtttct ctatgacact ttccctaaaa 250

 actttttctg gggtattggg actggagcat tgcaagtgga agggagttgg 300

 aagaaggatg gaaaaggacc ttctatatgg gatcatttca tccacacaca 350

 ccttaaaaat gtcagcagca cgaatggttc cagtgacagt tatatttttc 400

 tggaaaaaga cttatcagcc ctggatttta taggagtttc tttttatcaa 450

 ttttcaattt cctggccaag gcttttcccc gatggaatag taacagttgc 500

 caacgcaaaa ggtctgcagt actacagtac tcttctggac gctctagtgc 550

 ttagaaacat tgaacctata gttactttat accactggga tttgcctttg 600

 gcactacaag aaaaatatgg ggggtggaaa aatgatacca taatagatat 650

 cttcaatgac tatgccacat actgtttcca gatgtttggg gaccgtgtca 700

 aatattggat tacaattcac aacccatatc tagtggcttg gcatgggtat 750

 gggacaggta tgcatgcccc tggagagaag ggaaatttag cagctgtcta 800

 cactgtggga cacaacttga tcaaggctca ctcgaaagtt tggcataact 850

 acaacacaca tttccgccca catcagaagg gttggttatc gatcacgttg 900

 ggatctcatt ggatcgagcc aaaccggtcg gaaaacacga tggatatatt 950

 caaatgtcaa caatccatgg tttctgtgct tggatggttt gccaacccta 1000

 tccatgggga tggcgactat ccagagggga tgagaaagaa gttgttctcc 1050

 gttctaccca ttttctctga agcagagaag catgagatga gaggcacagc 1100

 tgatttcttt gccttttctt ttggacccaa caacttcaag cccctaaaca 1150

 ccatggctaa aatgggacaa aatgtttcac ttaatttaag agaagcgctg 1200

 aactggatta aactggaata caacaaccct cgaatcttga ttgctgcgaa 1250

 tggctggttc acagacagtc gtgtgaaaac agaagacacc acggccatct 1300

 acatgatgaa gaatttcctc agccaggtgc ttcaagcaat aaggttagat 1350

 gaaatacgag tgtttggtta tactgcctgg tctctcctgg atggctttga 1400

 atggcaggat gcttacacca tccgccgagg attattttat gtggatttta 1450

 acagtaaaca gaaagagcgg aaacctaagt cttcagcaca ctactacaaa 1500

 cagatcatac gagaaaatgg tttttcttta aaagagtcca cgccagatgt 1550

 gcagggccag tttccctgtg acttctcctg gggtgtcact gaatctgttc 1600

 ttaagcccga gtctgtggct tcgtccccac agttcagcga tcctcatctg 1650

 tacgtgtgga acgccactgg caacagactg ttgcaccgag tggaaggggt 1700

 gaggctgaaa acacgacccg ctcaatgcac agattttgta aacatcaaaa 1750

 aacaacttga gatgttggca agaatgaaag tcacccacta ccggtttgct 1800

 ctggattggg cctcggtcct tcccactggc aacctgtccg cggtgaaccg 1850

 acaggccctg aggtactaca ggtgcgtggt cagtgagggg ctgaagcttg 1900

 gcatctccgc gatggtcacc ctgtattatc cgacccacgc ccacctaggc 1950

 ctccccgagc ctctgttgca tgccgacggg tggctgaacc catcgacggc 2000

 cgaggccttc caggcctacg ctgggctgtg cttccaggag ctgggggacc 2050

 tggtgaagct ctggatcacc atcaacgcgc ctaaccggct aagtgacatc 2100

 tacaaccgct ctggcaacga cacctacggg gcggcgcaca acctgctggt 2150

 ggcccacgcc ctggcctggc gcctctacga ccggcagttc aggccctcac 2200

 agcgcggggc cgtgtcgctg tcgctgcacg cggactgggc ggaacccgcc 2250

 aacccctatg ctgactcgca ctggagggcg gccgagcgct tcctgcagtt 2300

 cgagatcgcc tggttcgccg agccgctctt caagaccggg gactaccccg 2350

 cggccatgag ggaatacatt gcctccaagc accgacgggg gctttccagc 2400

 tcggccctgc cgcgcctcac cgaggccgaa aggaggctgc tcaagggcac 2450

 ggtcgacttc tgcgcgctca accacttcac cactaggttc gtgatgcacg 2500

 agcagctggc cggcagccgc tacgactcgg acagggacat ccagtttctg 2550

 caggacatca cccgcctgag ctcccccacg cgcctggctg tgattccctg 2600

 gggggtgcgc aagctgctgc ggtgggtccg gaggaactac ggcgacatgg 2650

 acatttacat caccgccagt ggcatcgacg accaggctct ggaggatgac 2700

 cggctccgga agtactacct agggaagtac cttcaggagg tgctgaaagc 2750

 atacctgatt gataaagtca gaatcaaagg ctattatgca ttcaaactgg 2800

 ctgaagagaa atctaaaccc agatttggat tcttcacatc tgattttaaa 2850

 gctaaatcct caatacaatt ttacaacaaa gtgatcagca gcaggggctt 2900

 cccttttgag aacagtagtt ctagatgcag tcagacccaa gaaaatacag 2950

 agtgcactgt ctgcttattc cttgtgcaga agaaaccact gatattcctg 3000

 ggttgttgct tcttctccac cctggttcta ctcttatcaa ttgccatttt 3050

 tcaaaggcag aagagaagaa agttttggaa agcaaaaaac ttacaacaca 3100

 taccattaaa gaaaggcaag agagttgtta gcgattacaa ggatgacgac 3150

 gataagtaa 3159

<210> 53
<211> 11
<212> PRT
<213> Artificial sequence

<220>
<223> sequence was synthesized

<400> 53
 Lys Ala Ser Gln Asp Ile Asn Ser Phe Leu Ala
                   5                  10    

<210> 54
<211> 7
<212> PRT
<213> Artificial sequence

<220>
<223> sequence was synthesized

<400> 54
 Arg Ala Asn Arg Leu Val Ser
                   5        

<210> 55
<211> 9
<212> PRT
<213> Mus musculus

<400> 55
 Leu Gln Tyr Asp Glu Phe Pro Leu Thr
                   5                

<210> 56
<211> 10
<212> PRT
<213> Mus musculus

<400> 56
 Gly Phe Ser Leu Thr Thr Tyr Gly Val His
                   5                  10

<210> 57
<211> 17
<212> PRT
<213> Mus musculus

<400> 57
 Gly Val Ile Trp Pro Gly Gly Gly Thr Asp Tyr Asn Ala Ala Phe
   1               5                  10                  15

 Ile Ser
        

<210> 58
<211> 10
<212> PRT
<213> Mus musculus

<400> 58
 Val Arg Lys Glu Tyr Ala Asn Leu Tyr Ala
                   5                  10

