                               SEQUENCE LISTING                               

<110> DAVIDO, DAVID
      SCHAFFER, PRISCILLA

<120> HERPES SIMPLEX VIRUS MUTANT ICP0 PROTEIN

<130> 16994.1.1

<140>
<141>

<150> 60/948,048
<151> 2007-07-05

<160> 8                           

<170> PatentIn Ver. 3.3

<210> 1
<211> 3645
<212> DNA
<213> herpes simplex virus 1

<220> 
<221> CDS
<222> (3)..(59)

<220> 
<221> CDS
<222> (825)..(1490)

<220> 
<221> CDS
<222> (1627)..(3228)

<400> 1
cc atg gag ccc cgc ccc gga gcg agt acc cgc cgg cct gag ggc cgc    47    
   Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg
     1               5                  10                  15

ccc cag cgc gag gtgaggggcc gggcgccatg tctggggcgc catattgggg       99    
Pro Gln Arg Glu                                            

ggcgccatat tggggggcgc catgttgggg gacccccgac ccttacactg gaaccggccg 159   

ccatgttggg ggacccccac tcatacacgg gagccgggcg ccatgttggg gcgccatgtt 219   

agggggcgtg gaaccccgtg acactatata tacagggacc gggggcgcca tgttaggggg 279   

tgcggaaccc cctgacccta tatatacagg gaccggggtc gccctgttgg gggtcgccat 339   

gtgaccccct gactttatat atacagaccc ccaacacata cacatggccc ctttgactca 399   

gacgcagggc ccggggtcgc cgtgggaccc cctgactcat acacagagac acgcccccac 459   

aacaaacaca caaggaccgg ggtcgccgtg ttgggggcgt ggtccccact gactcatacg 519   

caggcccccc ttactcacac gcatctaggg gggtggggag gagccgcccg ccatatttgg 579   

gggacgccgt gggacccccg actccggtgc gtctggaggg cgggagaaga gggaagaaga 639   

ggggtcggga tccaaaggac ggacccagac cacctttggt tgcagacccc tttctccccc 699   

ctcttccgag gccagcaggg gggcaggact ttgtgaggcg ggggggggag agggggaact 759   

cgtgggtgct gattgacgcg ggaaatcccc ccccattctt acccgccccc cttttttccc 819   

cttag ccc gcc ccg gat gtc tgg gtg ttt ccc tgc gac cga gac ctg ccg 869   
      Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp Leu Pro
       20                  25                  30                

gac agc agc gac tct gag gcg gag acc gaa gtg ggg ggg cgg ggg gac   917   
Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg Gly Asp
 35                  40                  45                  50

gcc gac cac cat gac gac gac tcc gcc tcc gag gcg gac agc acg gac   965   
Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser Thr Asp
                 55                  60                  65    

acg gaa ctg ttc gag acg ggg ctg ctg ggg ccg cag ggc gtg gat ggg   1013  
Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val Asp Gly
             70                  75                  80        

ggg gcg gtc tcg ggg ggg agc ccc ccc cgc gag gaa gac ccc ggc agt   1061  
Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro Gly Ser
         85                  90                  95            

tgc ggg ggc gcc ccc cct cga gag gac ggg ggg agc gac gag ggc gac   1109  
Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu Gly Asp
    100                 105                 110                

gtg tgc gcc gtg tgc acg gat gag atc gcg ccc cac ctg cgc tgc gac   1157  
Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg Cys Asp
115                 120                 125                 130

acc ttc ccg tgc atg cac cgc ttc tgc atc ccg tgc atg aaa acc tgg   1205  
Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys Thr Trp
                135                 140                 145    

atg caa ttg cgc aac acc tgc ccg ctg tgc aac gcc aag ctg gtg tac   1253  
Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu Val Tyr
            150                 155                 160        

ctg ata gtg ggc gtg acg ccc agc ggg tcg ttc agc acc atc ccg atc   1301  
Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile Pro Ile
        165                 170                 175            

gtg aac gac ccc cag acc cgc atg gag gcc gag gag gcc gtc agg gcg   1349  
Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val Arg Ala
    180                 185                 190                

ggc acg gcc gtg gac ttt atc tgg acg ggc aat cag cgg ttc gcc ccg   1397  
Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe Ala Pro
195                 200                 205                 210

cgg tac ctg acc ctg ggg ggg cac acg gtg agg gcc ctg tcg ccc acc   1445  
Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser Pro Thr
                215                 220                 225    

cac ccg gag ccc acc acg gac gag gat gac gac gac ctg gac gac       1490  
His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp Asp
            230                 235                 240    

ggtgaggcgg ggggcggcaa ggaccctggg ggaggaggag gaggaggggg ggggagggag 1550  

gaataggcgg gcgggcgagg aaagggcggg ccggggaggg ggcgtaacct gatcgcgccc 1610  

cccgttgtct cttgca gca gac tac gta ccg ccc gcc ccc cgc cgg acg ccc 1662  
                  Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro
                              245                 250            

cgc gcc ccc cca cgc aga ggc gcc gcc gcg ccc ccc gtg acg ggc ggg   1710  
Arg Ala Pro Pro Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly
    255                 260                 265                

gcg tct cac gca gcc ccc cag ccg gcc gcg gct cgg aca gcg ccc ccc   1758  
Ala Ser His Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro
270                 275                 280                 285

tcg gcg ccc atc ggg cca cac ggc agc agt aac acc aac acc acc acc   1806  
Ser Ala Pro Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr
                290                 295                 300    

aac agc agc ggc ggc ggc ggc tcc cgc cag tcg cga gcc gcg gcg ccg   1854  
Asn Ser Ser Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Ala Pro
            305                 310                 315        

cgg ggg gcg tct ggc ccc tcc ggg ggg gtt ggg gtt ggg gtt ggg gtt   1902  
Arg Gly Ala Ser Gly Pro Ser Gly Gly Val Gly Val Gly Val Gly Val
        320                 325                 330            

gtt gaa gcg gag gcg ggg cgg ccg agg ggc cgg acg ggc ccc ctt gtc   1950  
Val Glu Ala Glu Ala Gly Arg Pro Arg Gly Arg Thr Gly Pro Leu Val
    335                 340                 345                

aac aga ccc gcc ccc ctt gca aac aac aga gac ccc ata gtg atc agc   1998  
Asn Arg Pro Ala Pro Leu Ala Asn Asn Arg Asp Pro Ile Val Ile Ser
350                 355                 360                 365

gac tcc ccc ccg gcc tct ccc cac agg ccc ccc gcg gcg ccc atg cca   2046  
Asp Ser Pro Pro Ala Ser Pro His Arg Pro Pro Ala Ala Pro Met Pro
                370                 375                 380    

ggc tcc gcc ccc cgc ccc ggg ccc ccc gcg tcc gcg gcc gcg tcg gga   2094  
Gly Ser Ala Pro Arg Pro Gly Pro Pro Ala Ser Ala Ala Ala Ser Gly
            385                 390                 395        

ccc gcg cgc ccc cgc gcg gcc gtg gcc ccg tgc gtg cga gcg ccg cct   2142  
Pro Ala Arg Pro Arg Ala Ala Val Ala Pro Cys Val Arg Ala Pro Pro
        400                 405                 410            

ccg ggg ccc ggc ccc cgc gcc ccg gcc ccc ggg gcg gag ccg gcc gcc   2190  
Pro Gly Pro Gly Pro Arg Ala Pro Ala Pro Gly Ala Glu Pro Ala Ala
    415                 420                 425                

cgc ccc gcg gac gcg cgc cgt gtg ccc cag tcg cac tcg tcc ctg gct   2238  
Arg Pro Ala Asp Ala Arg Arg Val Pro Gln Ser His Ser Ser Leu Ala
430                 435                 440                 445

cag gcc gcg aac caa gaa cag agt ctg tgc cgg gcg cgt gcg acg gtg   2286  
Gln Ala Ala Asn Gln Glu Gln Ser Leu Cys Arg Ala Arg Ala Thr Val
                450                 455                 460    

gcg cgc ggc tcg ggg ggg ccg ggc gtg gag ggt ggg cac ggg ccc tcc   2334  
Ala Arg Gly Ser Gly Gly Pro Gly Val Glu Gly Gly His Gly Pro Ser
            465                 470                 475        

cgc ggc gcc gcc ccc tcc ggc gcc gcc ccg ctc ccc tcc gcc gcc tct   2382  
Arg Gly Ala Ala Pro Ser Gly Ala Ala Pro Leu Pro Ser Ala Ala Ser
        480                 485                 490            

gtc gag cag gag gcg gcg gtg cgt ccg agg aag agg cgc ggg tcg ggc   2430  
Val Glu Gln Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly
    495                 500                 505                

cag gaa aac ccc tcc ccc cag tcc acg cgt ccc ccc ctc gcg ccg gca   2478  
Gln Glu Asn Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala
510                 515                 520                 525

ggg gcc aag agg gcg gcg acg cac ccc ccc tcc gac tca ggg ccg ggg   2526  
Gly Ala Lys Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly
                530                 535                 540    

ggg cgc ggc cag ggt ggg ccc ggg acc ccc ctg acg tcc tcg gcg gcc   2574  
Gly Arg Gly Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala
            545                 550                 555        

tcc gcc tct tcc tcc tct gcc tct tcc tcc tcg gcc ccg acc ccc gcg   2622  
Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala
        560                 565                 570            

ggg gcc gcc tct tcc gcc gcc ggg gcc gcg tcc tcc tcc gct tcc gcc   2670  
Gly Ala Ala Ser Ser Ala Ala Gly Ala Ala Ser Ser Ser Ala Ser Ala
    575                 580                 585                

tcc tcg ggc ggg gcc gtc ggt gcc ctg gga ggg aga caa gag gaa acc   2718  
Ser Ser Gly Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr
590                 595                 600                 605

tcc ctc ggc ccc cgc gct gct tct ggg ccg cgg ggg ccg agg aag tgt   2766  
Ser Leu Gly Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys
                610                 615                 620    

gcc cgg aag acg cgc cac gcg gag act tcc ggg gcc gtc ccc gcg ggc   2814  
Ala Arg Lys Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly
            625                 630                 635        

ggc ctc acg cgc tac ctg ccc atc tcg ggg gtc tct agc gtg gtc gcc   2862  
Gly Leu Thr Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala
        640                 645                 650            

ctg tcg cct tac gtg aac aag act atc acg ggg gac tgc ctg ccc atc   2910  
Leu Ser Pro Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile
    655                 660                 665                

ctg gac atg gag acg ggg aac atc ggg gcg tac gtg gtc ctg gtg gac   2958  
Leu Asp Met Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp
670                 675                 680                 685

cag acg gga aac atg gcg acc cgg ctg cgg gcc gcg gtc ccc ggc tgg   3006  
Gln Thr Gly Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp
                690                 695                 700    

agc cgc cgc acc ctg ctc ccc gag acc gcg ggt aac cac gtg atg ccc   3054  
Ser Arg Arg Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Met Pro
            705                 710                 715        

ccc gag tac ccg acg gcc ccc gcg tcg gag tgg aac agc ctc tgg atg   3102  
Pro Glu Tyr Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met
        720                 725                 730            

acc ccc gtg ggg aac atg ctg ttc gac cag ggc acc cta gtg ggc gcc   3150  
Thr Pro Val Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala
    735                 740                 745                

ctg gac ttc cgc agc ctg cgg tct cgg cac ccg tgg tcc ggg gag cag   3198  
Leu Asp Phe Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln
750                 755                 760                 765

ggg gcg tcg acc cgg gac gag gga aaa caa taagggacgc cccccgtgtt     3248  
Gly Ala Ser Thr Arg Asp Glu Gly Lys Gln                      
                770                 775                      

tgtggggagg ggggggtcgg gcgctgggtg gtctctggcc gcgcccacta caccagccaa 3308  

tccgtgtcgg ggaggggaaa agtgaaagac acgggcacca cacaccagcg ggtcttttgt 3368  

gttggcccta ataaaaaaaa actcagggga tttttgctgt ctgttgggaa ataaaggttt 3428  

acttttgtat cttttccctg tctgtgttgg atgtatcgcg gggatgcgtg ggagtggggg 3488  

tgcgtgggag tgggggtgcg tgggagtggg ggtgcgtggg agtgggggtg cgtgggagtg 3548  

ggggtgcgtg ggagtggggg tgcgtgggag tgggggtgcg tgggagtggg ggtgcgtggg 3608  

agtgggggtg ccatgttggg caggctctgg tgttaac                          3645  


<210> 2
<211> 775
<212> PRT
<213> herpes simplex virus 1

<400> 2
Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg Pro  
  1               5                  10                  15      

Gln Arg Glu Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp  
             20                  25                  30          

Leu Pro Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg  
         35                  40                  45              

Gly Asp Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser  
     50                  55                  60                  

Thr Asp Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val  
 65                  70                  75                  80  

Asp Gly Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro  
                 85                  90                  95      

Gly Ser Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu  
            100                 105                 110          

Gly Asp Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg  
        115                 120                 125              

Cys Asp Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys  
    130                 135                 140                  

Thr Trp Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu  
145                 150                 155                 160  

Val Tyr Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile  
                165                 170                 175      

Pro Ile Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val  
            180                 185                 190          

Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe  
        195                 200                 205              

Ala Pro Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser  
    210                 215                 220                  

Pro Thr His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp  
225                 230                 235                 240  

Asp Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro  
                245                 250                 255      

Pro Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His  
            260                 265                 270          

Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro  
        275                 280                 285              

Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser  
    290                 295                 300                  

Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Ala Pro Arg Gly Ala  
305                 310                 315                 320  

Ser Gly Pro Ser Gly Gly Val Gly Val Gly Val Gly Val Val Glu Ala  
                325                 330                 335      

Glu Ala Gly Arg Pro Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro  
            340                 345                 350          

Ala Pro Leu Ala Asn Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro  
        355                 360                 365              

Pro Ala Ser Pro His Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala  
    370                 375                 380                  

Pro Arg Pro Gly Pro Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg  
385                 390                 395                 400  

Pro Arg Ala Ala Val Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro  
                405                 410                 415      

Gly Pro Arg Ala Pro Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala  
            420                 425                 430          

Asp Ala Arg Arg Val Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala  
        435                 440                 445              

Asn Gln Glu Gln Ser Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly  
    450                 455                 460                  

Ser Gly Gly Pro Gly Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala  
465                 470                 475                 480  

Ala Pro Ser Gly Ala Ala Pro Leu Pro Ser Ala Ala Ser Val Glu Gln  
                485                 490                 495      

Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn  
            500                 505                 510          

Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys  
        515                 520                 525              

Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly  
    530                 535                 540                  

Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser  
545                 550                 555                 560  

Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Ala  
                565                 570                 575      

Ser Ser Ala Ala Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly  
            580                 585                 590          

Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly  
        595                 600                 605              

Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys  
    610                 615                 620                  

Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr  
625                 630                 635                 640  

Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro  
                645                 650                 655      

Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met  
            660                 665                 670          

Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly  
        675                 680                 685              

Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg  
    690                 695                 700                  

Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Met Pro Pro Glu Tyr  
705                 710                 715                 720  

Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val  
                725                 730                 735      

Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe  
            740                 745                 750          

Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser  
        755                 760                 765              

Thr Arg Asp Glu Gly Lys Gln                                      
    770                 775                                      



<210> 3
<211> 3298
<212> DNA
<213> herpes simplex virus 1

<220> 
<221> CDS
<222> (3)..(59)

<220> 
<221> CDS
<222> (866)..(1531)

<220> 
<221> CDS
<222> (1670)..(3271)

<400> 3
cc atg gag ccc cgc ccc gga gcg agt acc cgc cgg cct gag ggc cgc    47    
   Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg
     1               5                  10                  15

ccc cag cgc gag gtgaggggcc gggcgccatg tctggggcgc catgtctggg       99    
Pro Gln Arg Glu                                            

gcgccatgtc tggggcgcca tgtctggggc gccatgttgg ggggcgccat gttggggggc 159   

gccatgttgg gggacccccg acccttacac tggaaccggc cgccatgttg ggggaccccc 219   

actcatacac gggagccggg cgcccatgtt ggggcgccat gttagggggc gtggaacccc 279   

gtgacactat atatacaggg accgggggcg ccatgttagg gggcgcggaa ccccctgacc 339   

ctatatatac agggaccggg gtcgccctgt taggggtcgc catgtgaccc cctgacttta 399   

tatatacaga cccccaacac ctacacatgg cccctttgac tcagacgcag ggcccggggt 459   

cgccgtggga cccccctgac tcatacacag agacacgccc ccacaacaaa cacacaggga 519   

ccggggtcgc cgtgttgggg gcgtggtccc cactgactca tacgcagggc ccccttactc 579   

acacgcatct aggggggtgg ggaggagccg cccgccatat ttgggggacg ccgtgggacc 639   

cccgactccg gtgcgtctgg agggcgggag aagagggaag aagaggggtc gggatccaaa 699   

ggacggaccc agaccacctt tggttgcaga cccctttctc ccccctcttc cgaggccagc 759   

aggggggcag gactttgtga ggcggggggg ggagggggaa ctcgtgggcg ctgattgacg 819   

cgggaaatcc ccccattctt acccgccccc ccttttttcc cctcag ccc gcc ccg    874   
                                                   Pro Ala Pro
                                                    20        

gat gtc tgg gtg ttt ccc tgc gac cga gac ctg ccg gac agc agc gac   922   
Asp Val Trp Val Phe Pro Cys Asp Arg Asp Leu Pro Asp Ser Ser Asp
         25                  30                  35            

tcg gag gcg gag acc gaa gtg ggg ggg cgg ggg gac gcc gac cac cat   970   
Ser Glu Ala Glu Thr Glu Val Gly Gly Arg Gly Asp Ala Asp His His
     40                  45                  50                

gac gac gac tcc gcc tcc gag gcg gac agc acg gac acg gaa ctg ttc   1018  
Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser Thr Asp Thr Glu Leu Phe
 55                  60                  65                  70

gag acg ggg ctg ctg ggg ccg cag ggc gtg gat ggg ggg gcg gtc tcg   1066  
Glu Thr Gly Leu Leu Gly Pro Gln Gly Val Asp Gly Gly Ala Val Ser
                 75                  80                  85    

ggg ggg agc ccc ccc cgc gag gaa gac ccc ggc agt tgc ggg ggc gcc   1114  
Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro Gly Ser Cys Gly Gly Ala
             90                  95                 100        

ccc cct cga gag gac ggg ggg agc gac gag ggc gac gtg tgc gcc gtg   1162  
Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu Gly Asp Val Cys Ala Val
        105                 110                 115            

tgc acg gat gag atc gcg ccc cac ctg cgc tgc gac acc ttc ccg tgc   1210  
Cys Thr Asp Glu Ile Ala Pro His Leu Arg Cys Asp Thr Phe Pro Cys
    120                 125                 130                

atg cac cgc ttc tgc atc ccg tgc atg aaa acc tgg atg caa ttg cgc   1258  
Met His Arg Phe Cys Ile Pro Cys Met Lys Thr Trp Met Gln Leu Arg
135                 140                 145                 150

aac acc tgc ccg ctg tgc aac gcc aag ctg gtg tac ctg ata gtg ggc   1306  
Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu Val Tyr Leu Ile Val Gly
                155                 160                 165    

gtg acg ccc agc ggg tcg ttc agc acc atc ccg atc gtg aac gac ccc   1354  
Val Thr Pro Ser Gly Ser Phe Ser Thr Ile Pro Ile Val Asn Asp Pro
            170                 175                 180        

cag acc cgc atg gag gcc gag gag gcc gtc agg gcg ggc acg gcc gtg   1402  
Gln Thr Arg Met Glu Ala Glu Glu Ala Val Arg Ala Gly Thr Ala Val
        185                 190                 195            

gac ttt atc tgg acg ggc aat cag cgg ttc gcc ccg cgg tac ctg acc   1450  
Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe Ala Pro Arg Tyr Leu Thr
    200                 205                 210                

ctg ggg ggg cac acg gtg agg gcc ctg tcg ccc acc cac cct gag ccc   1498  
Leu Gly Gly His Thr Val Arg Ala Leu Ser Pro Thr His Pro Glu Pro
215                 220                 225                 230

acc acg gac gag gat gac gac gac ctg gac gac ggtgaggcgg gggggcggcg 1551  
Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp Asp                      
                235                 240                          

aggaccctgg gggaggagga ggaggggggg ggagggagga ataggcgggc gggcgggcga 1611  

ggaaagggcg ggccggggag ggggcgtaac ctgatcgcgc cccccgttgt ctcttgca   1669  

gca gac tac gta ccg ccc gcc ccc cgc cgg acg ccc cgc gcc ccc cca   1717  
Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro Pro
            245                 250                 255        

cgc aga ggc gcc gcc gcg ccc ccc gtg acg ggc ggg gcg tct cac gca   1765  
Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His Ala
        260                 265                 270            

gcc ccc cag ccg gcc gcg gct cgg aca gcg ccc ccc tcg gcg ccc atc   1813  
Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro Ile
    275                 280                 285                

ggg cca cac ggc agc agt aac act aac acc acc acc aac agc agc ggc   1861  
Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser Gly
290                 295                 300                 305

ggc ggc ggc tcc cgc cag tcg cga gcc gcg gtg ccg cgg ggg gcg tct   1909  
Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Val Pro Arg Gly Ala Ser
                310                 315                 320    

ggc ccc tcc ggg ggg gtt ggg gtt gtt gaa gcg gag gcg ggg cgg ccg   1957  
Gly Pro Ser Gly Gly Val Gly Val Val Glu Ala Glu Ala Gly Arg Pro
            325                 330                 335        

agg ggc cgg acg ggc ccc ctt gtc aac aga ccc gcc ccc ctt gca aac   2005  
Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro Ala Pro Leu Ala Asn
        340                 345                 350            

aac aga gac ccc ata gtg atc agc gac tcc ccc ccg gcc tct ccc cac   2053  
Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro Pro Ala Ser Pro His
    355                 360                 365                

agg ccc ccc gcg gcg ccc atg cca ggc tcc gcc ccc cgc ccc ggt ccc   2101  
Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala Pro Arg Pro Gly Pro
370                 375                 380                 385

ccc gcg tcc gcg gcc gcg tcg ggc ccc gcg cgc ccc cgc gcg gcc gtg   2149  
Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg Pro Arg Ala Ala Val
                390                 395                 400    

gcc ccg tgt gtg cgg gcg ccg cct ccg ggg ccc ggc ccc cgc gcc ccg   2197  
Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro Gly Pro Arg Ala Pro
            405                 410                 415        

gcc ccc ggg gcg gag ccg gcc gcc cgc ccc gcg gac gcg cgc cgt gtg   2245  
Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala Asp Ala Arg Arg Val
        420                 425                 430            

ccc cag tcg cac tcg tcc ctg gct cag gcc gcg aac caa gaa cag agt   2293  
Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala Asn Gln Glu Gln Ser
    435                 440                 445                

ctg tgc cgg gcg cgt gcg acg gtg gcg cgc ggc tcg ggg ggg ccg ggc   2341  
Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly Ser Gly Gly Pro Gly
450                 455                 460                 465

gtg gag ggt gga cac ggg ccc tcc cgc ggc gcc gcc ccc tcc ggc gcc   2389  
Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala Ala Pro Ser Gly Ala
                470                 475                 480    

gcc ccc tcc ggc gcc ccc ccg ctc ccc tcc gcc tct gtc gag cag gag   2437  
Ala Pro Ser Gly Ala Pro Pro Leu Pro Ser Ala Ser Val Glu Gln Glu
            485                 490                 495        

gcg gcg gtg cgt ccg agg aag agg cgc ggg tcg ggc cag gaa aac ccc   2485  
Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn Pro
        500                 505                 510            

tcc ccg cag tcc acg cgt ccc ccc ctc gcg ccg gca ggg gcc aag agg   2533  
Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys Arg
    515                 520                 525                

gcg gcg acg cac ccc ccc tcc gac tca ggg ccg ggg ggg cgc ggc cag   2581  
Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly Gln
530                 535                 540                 545

gga ggg ccc ggg acc ccc ctg acg tcc tcg gcg gcc tcc gcc tct tcc   2629  
Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser Ser
                550                 555                 560    

tcc tcc gcc tct tcc tcc tcg gcc ccg act ccc gcg ggg gcc acc tct   2677  
Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Thr Ser
            565                 570                 575        

tcc gcc acc ggg gcc gcg tcc tcc tcc gct tcc gcc tcc tcg ggc ggg   2725  
Ser Ala Thr Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly Gly
        580                 585                 590            

gcc gtc ggt gcc ctg gga ggg aga caa gag gaa acc tcc ctc ggc ccc   2773  
Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly Pro
    595                 600                 605                

cgc gct gct tct ggg ccg cgg ggg ccg agg aag tgt gcc cgg aag acg   2821  
Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys Thr
610                 615                 620                 625

cgc cac gcg gag act tcc ggg gcc gtc ccc gcg ggc ggc ctc acg cgc   2869  
Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr Arg
                630                 635                 640    

tac ctg ccc atc tcg ggg gtc tct agc gtg gtc gcc ctg tcg cct tac   2917  
Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro Tyr
            645                 650                 655        

gtg aac aag acg atc acg ggg gac tgc ctg ccc atc ctg gac atg gag   2965  
Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met Glu
        660                 665                 670            

acg ggg aac atc ggg gcg tac gtg gtc ctg gtg gac cag acg gga aac   3013  
Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly Asn
    675                 680                 685                

atg gcg acc cgg ctg cgg gcc gcg gtc ccc ggc tgg agc cgc cgc acc   3061  
Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg Thr
690                 695                 700                 705

ctg ctc ccc gag acc gcg ggt aac cac gtg acg ccc ccc gag tac ccg   3109  
Leu Leu Pro Glu Thr Ala Gly Asn His Val Thr Pro Pro Glu Tyr Pro
                710                 715                 720    

acg gcc ccc gcg tcg gag tgg aac agc ctc tgg atg acc ccc gtg ggg   3157  
Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val Gly
            725                 730                 735        

aac atg ctg ttc gac cag ggc acc cta gtg ggc gcc ctg gac ttc cgc   3205  
Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe Arg
        740                 745                 750            

agc ctg cgg tct cgg cac ccg tgg tcc ggg gag cag ggg gcg tcg acc   3253  
Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser Thr
    755                 760                 765                

cgg gac gag gga aaa caa taagggacgc ccccgtgttt gtgggga             3298  
Arg Asp Glu Gly Lys Gln                              
770                 775                              


<210> 4
<211> 775
<212> PRT
<213> herpes simplex virus 1

<400> 4
Met Glu Pro Arg Pro Gly Ala Ser Thr Arg Arg Pro Glu Gly Arg Pro  
  1               5                  10                  15      

Gln Arg Glu Pro Ala Pro Asp Val Trp Val Phe Pro Cys Asp Arg Asp  
             20                  25                  30          

Leu Pro Asp Ser Ser Asp Ser Glu Ala Glu Thr Glu Val Gly Gly Arg  
         35                  40                  45              

Gly Asp Ala Asp His His Asp Asp Asp Ser Ala Ser Glu Ala Asp Ser  
     50                  55                  60                  

Thr Asp Thr Glu Leu Phe Glu Thr Gly Leu Leu Gly Pro Gln Gly Val  
 65                  70                  75                  80  

Asp Gly Gly Ala Val Ser Gly Gly Ser Pro Pro Arg Glu Glu Asp Pro  
                 85                  90                  95      

Gly Ser Cys Gly Gly Ala Pro Pro Arg Glu Asp Gly Gly Ser Asp Glu  
            100                 105                 110          

Gly Asp Val Cys Ala Val Cys Thr Asp Glu Ile Ala Pro His Leu Arg  
        115                 120                 125              

Cys Asp Thr Phe Pro Cys Met His Arg Phe Cys Ile Pro Cys Met Lys  
    130                 135                 140                  

Thr Trp Met Gln Leu Arg Asn Thr Cys Pro Leu Cys Asn Ala Lys Leu  
145                 150                 155                 160  

Val Tyr Leu Ile Val Gly Val Thr Pro Ser Gly Ser Phe Ser Thr Ile  
                165                 170                 175      

Pro Ile Val Asn Asp Pro Gln Thr Arg Met Glu Ala Glu Glu Ala Val  
            180                 185                 190          

Arg Ala Gly Thr Ala Val Asp Phe Ile Trp Thr Gly Asn Gln Arg Phe  
        195                 200                 205              

Ala Pro Arg Tyr Leu Thr Leu Gly Gly His Thr Val Arg Ala Leu Ser  
    210                 215                 220                  

Pro Thr His Pro Glu Pro Thr Thr Asp Glu Asp Asp Asp Asp Leu Asp  
225                 230                 235                 240  

Asp Ala Asp Tyr Val Pro Pro Ala Pro Arg Arg Thr Pro Arg Ala Pro  
                245                 250                 255      

Pro Arg Arg Gly Ala Ala Ala Pro Pro Val Thr Gly Gly Ala Ser His  
            260                 265                 270          

Ala Ala Pro Gln Pro Ala Ala Ala Arg Thr Ala Pro Pro Ser Ala Pro  
        275                 280                 285              

Ile Gly Pro His Gly Ser Ser Asn Thr Asn Thr Thr Thr Asn Ser Ser  
    290                 295                 300                  

Gly Gly Gly Gly Ser Arg Gln Ser Arg Ala Ala Val Pro Arg Gly Ala  
305                 310                 315                 320  

Ser Gly Pro Ser Gly Gly Val Gly Val Val Glu Ala Glu Ala Gly Arg  
                325                 330                 335      

Pro Arg Gly Arg Thr Gly Pro Leu Val Asn Arg Pro Ala Pro Leu Ala  
            340                 345                 350          

Asn Asn Arg Asp Pro Ile Val Ile Ser Asp Ser Pro Pro Ala Ser Pro  
        355                 360                 365              

His Arg Pro Pro Ala Ala Pro Met Pro Gly Ser Ala Pro Arg Pro Gly  
    370                 375                 380                  

Pro Pro Ala Ser Ala Ala Ala Ser Gly Pro Ala Arg Pro Arg Ala Ala  
385                 390                 395                 400  

Val Ala Pro Cys Val Arg Ala Pro Pro Pro Gly Pro Gly Pro Arg Ala  
                405                 410                 415      

Pro Ala Pro Gly Ala Glu Pro Ala Ala Arg Pro Ala Asp Ala Arg Arg  
            420                 425                 430          

Val Pro Gln Ser His Ser Ser Leu Ala Gln Ala Ala Asn Gln Glu Gln  
        435                 440                 445              

Ser Leu Cys Arg Ala Arg Ala Thr Val Ala Arg Gly Ser Gly Gly Pro  
    450                 455                 460                  

Gly Val Glu Gly Gly His Gly Pro Ser Arg Gly Ala Ala Pro Ser Gly  
465                 470                 475                 480  

Ala Ala Pro Ser Gly Ala Pro Pro Leu Pro Ser Ala Ser Val Glu Gln  
                485                 490                 495      

Glu Ala Ala Val Arg Pro Arg Lys Arg Arg Gly Ser Gly Gln Glu Asn  
            500                 505                 510          

Pro Ser Pro Gln Ser Thr Arg Pro Pro Leu Ala Pro Ala Gly Ala Lys  
        515                 520                 525              

Arg Ala Ala Thr His Pro Pro Ser Asp Ser Gly Pro Gly Gly Arg Gly  
    530                 535                 540                  

Gln Gly Gly Pro Gly Thr Pro Leu Thr Ser Ser Ala Ala Ser Ala Ser  
545                 550                 555                 560  

Ser Ser Ser Ala Ser Ser Ser Ser Ala Pro Thr Pro Ala Gly Ala Thr  
                565                 570                 575      

Ser Ser Ala Thr Gly Ala Ala Ser Ser Ser Ala Ser Ala Ser Ser Gly  
            580                 585                 590          

Gly Ala Val Gly Ala Leu Gly Gly Arg Gln Glu Glu Thr Ser Leu Gly  
        595                 600                 605              

Pro Arg Ala Ala Ser Gly Pro Arg Gly Pro Arg Lys Cys Ala Arg Lys  
    610                 615                 620                  

Thr Arg His Ala Glu Thr Ser Gly Ala Val Pro Ala Gly Gly Leu Thr  
625                 630                 635                 640  

Arg Tyr Leu Pro Ile Ser Gly Val Ser Ser Val Val Ala Leu Ser Pro  
                645                 650                 655      

Tyr Val Asn Lys Thr Ile Thr Gly Asp Cys Leu Pro Ile Leu Asp Met  
            660                 665                 670          

Glu Thr Gly Asn Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly  
        675                 680                 685              

Asn Met Ala Thr Arg Leu Arg Ala Ala Val Pro Gly Trp Ser Arg Arg  
    690                 695                 700                  

Thr Leu Leu Pro Glu Thr Ala Gly Asn His Val Thr Pro Pro Glu Tyr  
705                 710                 715                 720  

Pro Thr Ala Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val  
                725                 730                 735      

Gly Asn Met Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe  
            740                 745                 750          

Arg Ser Leu Arg Ser Arg His Pro Trp Ser Gly Glu Gln Gly Ala Ser  
        755                 760                 765              

Thr Arg Asp Glu Gly Lys Gln                                      
    770                 775                                      



<210> 5
<211> 78
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
ctgggggggc acacggtgag ggccctagcg ccggcccacc ctgagccggc cgcggacgag 60    
gatgacgacg acctggac                                               78    


<210> 6
<211> 71
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
gcaaacaaca gagaccccat agtgatcgcc gatgcccccc cggccgctcc cacaggcccc 60    
ccgcggcgcc c                                                      71    


<210> 7
<211> 85
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
gcggtgcgtc cgaggaagag gcgcggggcc ggccaggaaa accccgcccc gcaggccgcg 60    
cgtccccccc tcgcgccggc agggg                                       85    


<210> 8
<211> 825
<212> PRT
<213> herpes simplex virus 2

<400> 8
Met Glu Pro Arg Pro Gly Thr Ser Ser Arg Ala Asp Pro Gly Pro Glu  
  1               5                  10                  15    

Arg Pro Pro Arg Gln Thr Pro Gly Thr Gln Pro Ala Ala Pro His Ala  
             20                  25                  30        

Trp Gly Met Leu Asn Asp Met Gln Trp Leu Ala Ser Ser Asp Ser Glu  
         35                  40                  45            

Glu Glu Thr Glu Val Gly Ile Ser Asp Asp Asp Leu His Arg Asp Ser  
     50                  55                  60                

Thr Ser Glu Ala Gly Ser Thr Asp Thr Glu Met Phe Glu Ala Gly Leu  
 65                  70                  75                  80

Met Asp Ala Ala Thr Pro Pro Ala Arg Pro Pro Ala Glu Arg Gln Gly  
                 85                  90                  95    

Ser Pro Thr Pro Ala Asp Ala Gln Gly Ser Cys Gly Gly Gly Pro Val  
            100                 105                 110        

Gly Glu Glu Glu Ala Glu Ala Gly Gly Gly Gly Asp Val Cys Ala Val  
        115                 120                 125            

Cys Thr Asp Glu Ile Ala Pro Pro Leu Arg Cys Gln Ser Phe Pro Cys  
    130                 135                 140                

Leu His Pro Phe Cys Ile Pro Cys Met Lys Thr Trp Ile Pro Leu Arg  
145                 150                 155                 160

Asn Thr Cys Pro Leu Cys Asn Thr Pro Val Ala Tyr Leu Ile Val Gly  
                165                 170                 175    

Val Thr Ala Ser Gly Ser Phe Ser Thr Ile Pro Ile Val Asn Asp Pro  
            180                 185                 190        

Arg Thr Arg Val Glu Ala Glu Ala Ala Val Arg Ala Gly Thr Ala Val  
        195                 200                 205            

Asp Phe Ile Trp Thr Gly Asn Pro Arg Thr Ala Pro Arg Ser Leu Ser  
    210                 215                 220                

Leu Gly Gly His Thr Val Arg Ala Leu Ser Pro Thr Pro Pro Trp Pro  
225                 230                 235                 240

Gly Thr Asp Asp Glu Asp Asp Asp Leu Ala Asp Val Asp Tyr Val Pro  
                245                 250                 255    

Pro Ala Pro Arg Arg Ala Pro Arg Arg Gly Gly Gly Gly Ala Gly Ala  
            260                 265                 270        

Thr Arg Gly Thr Ser Gln Pro Ala Ala Thr Arg Pro Ala Pro Pro Gly  
        275                 280                 285            

Ala Pro Arg Ser Ser Ser Ser Gly Gly Ala Pro Leu Arg Ala Gly Val  
    290                 295                 300                

Gly Ser Gly Ser Gly Gly Gly Pro Ala Val Ala Ala Val Val Pro Arg  
305                 310                 315                 320

Val Ala Ser Leu Pro Pro Ala Ala Gly Gly Gly Arg Ala Gln Ala Arg  
                325                 330                 335    

Arg Val Gly Glu Asp Ala Ala Ala Ala Glu Gly Arg Thr Pro Pro Ala  
            340                 345                 350        

Arg Gln Pro Arg Ala Ala Gln Glu Pro Pro Ile Val Ile Ser Asp Ser  
        355                 360                 365            

Pro Pro Pro Ser Pro Arg Arg Pro Ala Gly Pro Gly Pro Leu Ser Phe  
    370                 375                 380                

Val Ser Ser Ser Ser Ala Gln Val Ser Ser Gly Pro Gly Gly Gly Gly  
385                 390                 395                 400

Leu Pro Gln Ser Ser Gly Arg Ala Ala Arg Pro Arg Ala Ala Val Ala  
                405                 410                 415    

Pro Arg Val Arg Ser Pro Pro Arg Ala Ala Ala Ala Pro Val Val Ser  
            420                 425                 430        

Ala Ser Ala Asp Ala Ala Gly Pro Ala Pro Pro Ala Val Pro Val Asp  
        435                 440                 445            

Ala His Arg Ala Pro Arg Ser Arg Met Thr Gln Ala Gln Thr Asp Thr  
    450                 455                 460                

Gln Ala Gln Ser Leu Gly Arg Ala Gly Ala Thr Asp Ala Arg Gly Ser  
465                 470                 475                 480

Gly Gly Pro Gly Ala Glu Gly Gly Pro Gly Val Pro Arg Gly Thr Asn  
                485                 490                 495    

Thr Pro Gly Ala Ala Pro His Ala Ala Glu Gly Ala Ala Ala Arg Pro  
            500                 505                 510        

Arg Lys Arg Arg Gly Ser Asp Ser Gly Pro Ala Ala Ser Ser Ser Ala  
        515                 520                 525            

Ser Ser Ser Ala Ala Pro Arg Ser Pro Leu Ala Pro Gln Gly Val Gly  
    530                 535                 540                

Ala Lys Arg Ala Ala Pro Arg Arg Ala Pro Asp Ser Asp Ser Gly Asp  
545                 550                 555                 560

Arg Gly His Gly Pro Leu Ala Pro Ala Ser Ala Gly Ala Ala Pro Pro  
                565                 570                 575    

Ser Ala Ser Pro Ser Ser Gln Ala Ala Val Ala Ala Ala Ser Ser Ser  
            580                 585                 590        

Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser  
        595                 600                 605            

Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala Ser Ser Ser Ser Ala  
    610                 615                 620                

Ser Ser Ser Ala Gly Gly Ala Gly Gly Ser Val Ala Ser Ala Ser Gly  
625                 630                 635                 640

Ala Gly Glu Arg Arg Glu Thr Ser Leu Gly Pro Arg Ala Ala Ala Pro  
                645                 650                 655    

Arg Gly Pro Arg Lys Cys Ala Arg Lys Thr Arg His Ala Glu Gly Gly  
            660                 665                 670        

Pro Glu Pro Gly Ala Arg Asp Pro Ala Pro Gly Leu Thr Arg Tyr Leu  
        675                 680                 685            

Pro Ile Ala Gly Val Ser Ser Val Val Ala Leu Ala Pro Tyr Val Asn  
    690                 695                 700                

Lys Thr Val Thr Gly Asp Cys Leu Pro Val Leu Asp Met Glu Thr Gly  
705                 710                 715                 720

His Ile Gly Ala Tyr Val Val Leu Val Asp Gln Thr Gly Asn Val Ala  
                725                 730                 735    

Asp Leu Leu Arg Ala Ala Ala Pro Ala Trp Ser Arg Arg Thr Leu Leu  
            740                 745                 750        

Pro Glu His Ala Arg Asn Cys Val Arg Pro Pro Asp Tyr Pro Thr Pro  
        755                 760                 765            

Pro Ala Ser Glu Trp Asn Ser Leu Trp Met Thr Pro Val Gly Asn Met  
    770                 775                 780                

Leu Phe Asp Gln Gly Thr Leu Val Gly Ala Leu Asp Phe His Gly Leu  
785                 790                 795                 800

Arg Ser Arg His Pro Trp Ser Arg Glu Gln Gly Ala Pro Ala Pro Ala  
                805                 810                 815    

Gly Asp Ala Pro Ala Gly His Gly Glu                              
            820                 825




