                         SEQUENCE LISTING

<110>  Bristol-Myers Squibb Company
       Hanson, Ronald L.
       Goswami, Animesh
       Davis, Brian L.
       Parker, William L.
       Patel, Ramesh N.
 
<120>  STEREOSELECTIVE RESOLUTION OF RACEMIC AMINES

<130>  10400 PCT

<150>  60/947,491
<151>  2007-07-02

<160>  18    

<170>  PatentIn version 3.4

<210>  1
<211>  1425
<212>  DNA
<213>  Bacillus megaterium


<220>
<221>  misc_feature
<222>  (603)..(603)
<223>  n is a, c, g, or t

<400>  1
atgagtttaa cagtgcaaaa aataaactgg gagcaagtta aagaatggga tcgtaaatac     60

ctgatgagga cgtttagtac ccaaaatgag tatcaacctg taccaattga atcaacagaa    120

ggtgactatt tgattatgcc tgatggcaca agattattag atttcttcaa tcaactttat    180

tgtgtcaatt taggtcagaa aaatcaaaaa gttaatgctg caatcaagga ggctttagac    240

cgatatggtt ttgtatggga tacttatgca actgattata aagccaaagc agcaaagata    300

attattgagg atattttagg tgatgaagac tggccaggaa aagttaggtt cgtatcaaca    360

ggaagtgaag cagtggaaac ggcactgaat atcgcgaggt tatatacaaa tcgcccacta    420

gtggttacac gagaacacga ttatcatggt tggactggtg gagctgctac tgttactcga    480

ttaaggtcat atcgaagtgg tttagttggg gaaaattcag aatctttttc agcacaaata    540

cccgggtcat catataatag tgctgttttg atggcgccat cccctaacat gtttcaggat    600

tcngacggca acytgctaaa agatgaaaac ggggaattgt tgagtgtaaa gtatacacgt    660

cgtatgatcg aaaactatgg tccggaacaa gtggcagcag tgataactga agtatcgcar    720

ggtgcaggct ctgctatgcc cccatatgaa tacattccac aaatccgaaa aatgacaaaa    780

gaactaggtg tcctttggat taatgatgaa gttcttactg gctttgggcg aacagggaag    840

tggtttggat atcagcayta tggggtacag ccagatataa tcactatggg taaaggactc    900

tccagttcct cactccctgc tggcgctgtc ttagttagta aggaaattgc agcgtttatg    960

gataagcacc gatgggagtc agtatccacg tatgccggtc atccagttgc gatggctgcg   1020

gtctgtgcaa atttagaagt gatgatggaa gaaaactttg ttgagcaagc gaaggacagc   1080

ggcgagtata taaggagtaa acttgaactt ctgcaagaaa agcataaaag tataggaaat   1140

ttcgacggat atggcctttt atggatagta gatattgtga atgccaagac taagactcct   1200

tacgtaaaat tggaccggaa ctttacgcac gggatgaatc caaatcaaat cccaacacaa   1260

atcattatga aaaaagcgct agaaaaagga gtgctgattg gtggagtaat gcctaataca   1320

atgagaattg gcgcatcttt gaatgttagt cgcggagaca tcgataaagc aatggatgca   1380

ctggattatg cacttgacta tttagaaagt ggagaatggc agtaa                   1425


<210>  2
<211>  474
<212>  PRT
<213>  Bacillus megaterium

<400>  2

Met Ser Leu Thr Val Gln Lys Ile Asn Trp Glu Gln Val Lys Glu Trp 
1               5                   10                  15      


Asp Arg Lys Tyr Leu Met Arg Thr Phe Ser Thr Gln Asn Glu Tyr Gln 
            20                  25                  30          


Pro Val Pro Ile Glu Ser Thr Glu Gly Asp Tyr Leu Ile Met Pro Asp 
        35                  40                  45              


Gly Thr Arg Leu Leu Asp Phe Phe Asn Gln Leu Tyr Cys Val Asn Leu 
    50                  55                  60                  


Gly Gln Lys Asn Gln Lys Val Asn Ala Ala Ile Lys Glu Ala Leu Asp 
65                  70                  75                  80  


Arg Tyr Gly Phe Val Trp Asp Thr Tyr Ala Thr Asp Tyr Lys Ala Lys 
                85                  90                  95      


Ala Ala Lys Ile Ile Ile Glu Asp Ile Leu Gly Asp Glu Asp Trp Pro 
            100                 105                 110         


Gly Lys Val Arg Phe Val Ser Thr Gly Ser Glu Ala Val Glu Thr Ala 
        115                 120                 125             


Leu Asn Ile Ala Arg Leu Tyr Thr Asn Arg Pro Leu Val Val Thr Arg 
    130                 135                 140                 


Glu His Asp Tyr His Gly Trp Thr Gly Gly Ala Ala Thr Val Thr Arg 
145                 150                 155                 160 


Leu Arg Ser Tyr Arg Ser Gly Leu Val Gly Glu Asn Ser Glu Ser Phe 
                165                 170                 175     


Ser Ala Gln Ile Pro Gly Ser Ser Tyr Asn Ser Ala Val Leu Met Ala 
            180                 185                 190         


Pro Ser Pro Asn Met Phe Gln Asp Ser Asp Gly Asn Leu Leu Lys Asp 
        195                 200                 205             


Glu Asn Gly Glu Leu Leu Ser Val Lys Tyr Thr Arg Arg Met Ile Glu 
    210                 215                 220                 


Asn Tyr Gly Pro Glu Gln Val Ala Ala Val Ile Thr Glu Val Ser Gln 
225                 230                 235                 240 


Gly Ala Gly Ser Ala Met Pro Pro Tyr Glu Tyr Ile Pro Gln Ile Arg 
                245                 250                 255     


Lys Met Thr Lys Glu Leu Gly Val Leu Trp Ile Asn Asp Glu Val Leu 
            260                 265                 270         


Thr Gly Phe Gly Arg Thr Gly Lys Trp Phe Gly Tyr Gln His Tyr Gly 
        275                 280                 285             


Val Gln Pro Asp Ile Ile Thr Met Gly Lys Gly Leu Ser Ser Ser Ser 
    290                 295                 300                 


Leu Pro Ala Gly Ala Val Leu Val Ser Lys Glu Ile Ala Ala Phe Met 
305                 310                 315                 320 


Asp Lys His Arg Trp Glu Ser Val Ser Thr Tyr Ala Gly His Pro Val 
                325                 330                 335     


Ala Met Ala Ala Val Cys Ala Asn Leu Glu Val Met Met Glu Glu Asn 
            340                 345                 350         


Phe Val Glu Gln Ala Lys Asp Ser Gly Glu Tyr Ile Arg Ser Lys Leu 
        355                 360                 365             


Glu Leu Leu Gln Glu Lys His Lys Ser Ile Gly Asn Phe Asp Gly Tyr 
    370                 375                 380                 


Gly Leu Leu Trp Ile Val Asp Ile Val Asn Ala Lys Thr Lys Thr Pro 
385                 390                 395                 400 


Tyr Val Lys Leu Asp Arg Asn Phe Thr His Gly Met Asn Pro Asn Gln 
                405                 410                 415     


Ile Pro Thr Gln Ile Ile Met Lys Lys Ala Leu Glu Lys Gly Val Leu 
            420                 425                 430         


Ile Gly Gly Val Met Pro Asn Thr Met Arg Ile Gly Ala Ser Leu Asn 
        435                 440                 445             


Val Ser Arg Gly Asp Ile Asp Lys Ala Met Asp Ala Leu Asp Tyr Ala 
    450                 455                 460                 


Leu Asp Tyr Leu Glu Ser Gly Glu Trp Gln 
465                 470                 


<210>  3
<211>  14
<212>  PRT
<213>  Bacillus megaterium


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<400>  3

Ser Leu Thr Val Gln Lys Ile Asn Xaa Glu Gln Val Lys Glu 
1               5                   10                  


<210>  4
<211>  11
<212>  PRT
<213>  Bacillus megaterium

<400>  4

Leu Tyr Thr Asn Arg Pro Leu Val Val Thr Arg 
1               5                   10      


<210>  5
<211>  13
<212>  PRT
<213>  Bacillus megaterium

<400>  5

Ser Val Leu Ile Gly Gly Val Met Pro Asn Cys Met Arg 
1               5                   10              


<210>  6
<211>  9
<212>  PRT
<213>  Bacillus megaterium

<400>  6

Ile Gly Ala Ser Leu Asn Val Ser Arg 
1               5                   


<210>  7
<211>  17
<212>  PRT
<213>  Bacillus megaterium

<400>  7

Phe Val Ser Thr Gly Ser Glu Ala Val Glu Thr Ala Leu Asn Ile Ala 
1               5                   10                  15      


Arg 
    


<210>  8
<211>  15
<212>  PRT
<213>  Bacillus megaterium

<400>  8

Gly Leu Ser Ser Ser Ser Leu Pro Ala Gly Ala Val Leu Val Ser 
1               5                   10                  15  


<210>  9
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  9

Thr Ile Gly Thr Ile Cys Ala Arg Ala Ala Arg Ala Thr His Ala Ala 
1               5                   10                  15      


Tyr 
    


<210>  10
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  10

Leu Val Gln Lys Ile Asn 
1               5       


<210>  11
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  11

Gly Ala Arg Gly Cys Ile Gly Thr Ile Gly Ala Arg Ala Cys Ile Gly 
1               5                   10                  15      


Cys Ile Tyr Thr 
            20  


<210>  12
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  12

Glu Ala Val Glu Thr Ala Leu 
1               5           


<210>  13
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  13

Ala Arg Ile Gly Cys Ile Gly Thr Tyr Thr Cys Ile Ala Cys Ile Gly 
1               5                   10                  15      


Cys Tyr Thr Cys 
            20  


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  14

Gly Ile Val Val Glu Ala Tyr 
1               5           


<210>  15
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  15

Ala Arg Ile Ala Cys Ile Gly Cys Ile Cys Cys Ile Gly Cys Ile Gly 
1               5                   10                  15      


Gly Ile Ala 
            


<210>  16
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  16

Leu Pro Ala Gly Ala Val Leu 
1               5           


<210>  17
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  17

Gly Ala Cys Ala Thr Ala Thr Thr Thr Ala Ala Ala Thr Cys Ala Thr 
1               5                   10                  15      


Ala Thr Gly Ala Gly Thr Thr Thr Ala Ala Cys Ala Gly Thr Gly Cys 
            20                  25                  30          


Ala Ala Ala Ala Ala Ala Thr Ala Ala Ala Cys 
        35                  40              


<210>  18
<211>  42
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Peptide

<400>  18

Gly Ala Cys Ala Thr Ala Thr Thr Thr Ala Ala Ala Thr Cys Cys Ala 
1               5                   10                  15      


Thr Gly Gly Gly Thr Thr Thr Ala Ala Cys Ala Gly Thr Gly Cys Ala 
            20                  25                  30          


Ala Ala Ala Ala Ala Thr Ala Ala Ala Cys 
        35                  40          


