
                                SEQUENCE LISTING

<110> Isis Pharmaceuticals, Inc.
      SETH, Punit P.
      SWAYZE, Eric E.

<120> 6-DISUBSTITUTED BICYCLIC NUCLEIC ACID
      ANALOGS

<130> CHEM0039WO

<150> 60/948,134          
<151> 2007-07-05  

<160> 6

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 3160
<212> DNA
<213> H. Sapiens

<400> 1
cctcccctcg cccggcgcgg tcccgtccgc ctctcgctcg cctcccgcct cccctcggtc 60
ttccgaggcg cccgggctcc cggcgcggcg gcggaggggg cgggcaggcc ggcgggcggt 120
gatgtggcag gactctttat gcgctgcggc aggatacgcg ctcggcgctg ggacgcgact 180
gcgctcagtt ctctcctctc ggaagctgca gccatgatgg aagtttgaga gttgagccgc 240
tgtgaggcga ggccgggctc aggcgaggga gatgagagac ggcggcggcc gcggcccgga 300
gcccctctca gcgcctgtga gcagccgcgg gggcagcgcc ctcggggagc cggccggcct 360
gcggcggcgg cagcggcggc gtttctcgcc tcctcttcgt cttttctaac cgtgcagcct 420
cttcctcggc ttctcctgaa agggaaggtg gaagccgtgg gctcgggcgg gagccggctg 480
aggcgcggcg gcggcggcgg cggcacctcc cgctcctgga gcggggggga gaagcggcgg 540
cggcggcggc cgcggcggct gcagctccag ggagggggtc tgagtcgcct gtcaccattt 600
ccagggctgg gaacgccgga gagttggtct ctccccttct actgcctcca acacggcggc 660
ggcggcggcg gcacatccag ggacccgggc cggttttaaa cctcccgtcc gccgccgccg 720
caccccccgt ggcccgggct ccggaggccg ccggcggagg cagccgttcg gaggattatt 780
cgtcttctcc ccattccgct gccgccgctg ccaggcctct ggctgctgag gagaagcagg 840
cccagtcgct gcaaccatcc agcagccgcc gcagcagcca ttacccggct gcggtccaga 900
gccaagcggc ggcagagcga ggggcatcag ctaccgccaa gtccagagcc atttccatcc 960
tgcagaagaa gccccgccac cagcagcttc tgccatctct ctcctccttt ttcttcagcc 1020
acaggctccc agacatgaca gccatcatca aagagatcgt tagcagaaac aaaaggagat 1080
atcaagagga tggattcgac ttagacttga cctatattta tccaaacatt attgctatgg 1140
gatttcctgc agaaagactt gaaggcgtat acaggaacaa tattgatgat gtagtaaggt 1200
ttttggattc aaagcataaa aaccattaca agatatacaa tctttgtgct gaaagacatt 1260
atgacaccgc caaatttaat tgcagagttg cacaatatcc ttttgaagac cataacccac 1320
cacagctaga acttatcaaa cccttttgtg aagatcttga ccaatggcta agtgaagatg 1380
acaatcatgt tgcagcaatt cactgtaaag ctggaaaggg acgaactggt gtaatgatat 1440
gtgcatattt attacatcgg ggcaaatttt taaaggcaca agaggcccta gatttctatg 1500
gggaagtaag gaccagagac aaaaagggag taactattcc cagtcagagg cgctatgtgt 1560
attattatag ctacctgtta aagaatcatc tggattatag accagtggca ctgttgtttc 1620
acaagatgat gtttgaaact attccaatgt tcagtggcgg aacttgcaat cctcagtttg 1680
tggtctgcca gctaaaggtg aagatatatt cctccaattc aggacccaca cgacgggaag 1740
acaagttcat gtactttgag ttccctcagc cgttacctgt gtgtggtgat atcaaagtag 1800
agttcttcca caaacagaac aagatgctaa aaaaggacaa aatgtttcac ttttgggtaa 1860
atacattctt cataccagga ccagaggaaa cctcagaaaa agtagaaaat ggaagtctat 1920
gtgatcaaga aatcgatagc atttgcagta tagagcgtgc agataatgac aaggaatatc 1980
tagtacttac tttaacaaaa aatgatcttg acaaagcaaa taaagacaaa gccaaccgat 2040
acttttctcc aaattttaag gtgaagctgt acttcacaaa aacagtagag gagccgtcaa 2100
atccagaggc tagcagttca acttctgtaa caccagatgt tagtgacaat gaacctgatc 2160
attatagata ttctgacacc actgactctg atccagagaa tgaacctttt gatgaagatc 2220
agcatacaca aattacaaaa gtctgaattt ttttttatca agagggataa aacaccatga 2280
aaataaactt gaataaactg aaaatggacc tttttttttt taatggcaat aggacattgt 2340
gtcagattac cagttatagg aacaattctc ttttcctgac caatcttgtt ttaccctata 2400
catccacagg gttttgacac ttgttgtcca gttgaaaaaa ggttgtgtag ctgtgtcatg 2460
tatatacctt tttgtgtcaa aaggacattt aaaattcaat taggattaat aaagatggca 2520
ctttcccgtt ttattccagt tttataaaaa gtggagacag actgatgtgt atacgtagga 2580
attttttcct tttgtgttct gtcaccaact gaagtggcta aagagctttg tgatatactg 2640
gttcacatcc tacccctttg cacttgtggc aacagataag tttgcagttg gctaagagag 2700
gtttccgaaa ggttttgcta ccattctaat gcatgtattc gggttagggc aatggagggg 2760
aatgctcaga aaggaaataa ttttatgctg gactctggac catataccat ctccagctat 2820
ttacacacac ctttctttag catgctacag ttattaatct ggacattcga ggaattggcc 2880
gctgtcactg cttgttgttt gcgcattttt ttttaaagca tattggtgct agaaaaggca 2940
gctaaaggaa gtgaatctgt attggggtac aggaatgaac cttctgcaac atcttaagat 3000
ccacaaatga agggatataa aaataatgtc ataggtaaga aacacagcaa caatgactta 3060
accatataaa tgtggaggct atcaacaaag aatgggcttg aaacattata aaaattgaca 3120
atgatttatt aaatatgttt tctcaattgt aaaaaaaaaa                       3160

<210> 2
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 2
aatggctaag tgaagatgac aatcat                                      26

<210> 3
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 3
tgcacatatc attacaccag ttcgt                                       25

<210> 4
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Probe

<400> 4
ttgcagcaat tcactgtaaa gctggaaagg                                  30

<210> 5
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Oligonucleotide

<220>
<221> misc_feature   
<222> (3)...(12)
<223> Bases at these positions are RNA

<400> 5
cutagcactg gccu                                                   14

<210> 6
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Oligonucleotide

<400> 6
cttagcactg gcct                                                   14
