                         SEQUENCE LISTING

<100>  ABBOTT LABORATORIES
 
<120>  Methods and Marker Combinations For Screening for Predisposition 
       To Lung Cancer

<130>  065483-1246

<150>  11/771,727
<151>  2007-06-29

<160>  10    

<170>  PatentIn version 3.2

<210>  1
<211>  296
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Lys Glu Val Trp Leu Asn Met Leu Lys Lys Glu Ser Arg Tyr 
1               5                   10                  15      


Val His Asp Lys His Phe Glu Val Leu His Ser Asp Leu Glu Pro Gln 
            20                  25                  30          


Met Arg Ser Ile Leu Leu Asp Trp Leu Leu Glu Val Cys Glu Val Tyr 
        35                  40                  45              


Thr Leu His Arg Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg 
    50                  55                  60                  


Phe Met Leu Thr Gln Lys Asp Ile Asn Lys Asn Met Leu Gln Leu Ile 
65                  70                  75                  80  


Gly Ile Thr Ser Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr Ala 
                85                  90                  95      


Pro Lys Leu Gln Glu Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Glu 
            100                 105                 110         


Glu Asp Ile Leu Arg Met Glu Leu Ile Ile Leu Lys Ala Leu Lys Trp 
        115                 120                 125             


Glu Leu Cys Pro Val Thr Ile Ile Ser Trp Leu Asn Leu Phe Leu Gln 
    130                 135                 140                 


Val Asp Ala Leu Lys Asp Ala Pro Lys Val Leu Leu Pro Gln Tyr Ser 
145                 150                 155                 160 


Gln Glu Thr Phe Ile Gln Ile Ala Gln Leu Leu Asp Leu Cys Ile Leu 
                165                 170                 175     


Ala Ile Asp Ser Leu Glu Phe Gln Tyr Arg Ile Leu Thr Ala Ala Ala 
            180                 185                 190         


Leu Cys His Phe Thr Ser Ile Glu Val Val Lys Lys Ala Ser Gly Leu 
        195                 200                 205             


Glu Trp Asp Ser Ile Ser Glu Cys Val Asp Trp Met Val Pro Phe Val 
    210                 215                 220                 


Asn Val Val Lys Ser Thr Ser Pro Val Lys Leu Lys Thr Phe Lys Lys 
225                 230                 235                 240 


Ile Pro Met Glu Asp Arg His Asn Ile Gln Thr His Thr Asn Tyr Leu 
                245                 250                 255     


Ala Met Leu Glu Glu Val Asn Tyr Ile Asn Thr Phe Arg Lys Gly Gly 
            260                 265                 270         


Gln Leu Ser Pro Val Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser 
        275                 280                 285             


Thr Glu Lys Pro Pro Gly Lys His 
    290                 295     


<210>  2
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Arg Arg Ser Ser Arg Leu Gln Ala Lys Gln Gln Pro Gln Pro 
1               5                   10                  15      


Ser Gln Thr Glu Ser Pro Gln Glu Ala Gln Ile Ile Gln Ala Lys Lys 
            20                  25                  30          


Arg Lys Thr Thr Gln Asp Val Lys Lys Arg Arg Glu Glu Val Thr Lys 
        35                  40                  45              


Lys His Gln Tyr Glu Ile Arg Asn Cys Trp Pro Pro Val Leu Ser Gly 
    50                  55                  60                  


Gly Ile Ser Pro Cys Ile Ile Ile Glu Thr Pro His Lys Glu Ile Gly 
65                  70                  75                  80  


Thr Ser Asp Phe Ser Arg Phe Thr Asn Tyr Arg Phe Lys Asn Leu Phe 
                85                  90                  95      


Ile Asn Pro Ser Pro Leu Pro Asp Leu Ser Trp Gly Cys Ser Lys Glu 
            100                 105                 110         


Val Trp Leu Asn Met Leu Lys Lys Glu Ser Arg Tyr Val His Asp Lys 
        115                 120                 125             


His Phe Glu Val Leu His Ser Asp Leu Glu Pro Gln Met Arg Ser Ile 
    130                 135                 140                 


Leu Leu Asp Trp Leu Leu Glu Val Cys Glu Val Tyr Thr Leu His Arg 
145                 150                 155                 160 


Glu Thr Phe Tyr Leu Ala Gln Asp Phe Phe Asp Arg Phe Met Leu Thr 
                165                 170                 175     


Gln Lys Asp Ile Asn Lys Asn Met Leu Gln Leu Ile Gly Ile Thr Ser 
            180                 185                 190         


Leu Phe Ile Ala Ser Lys Leu Glu Glu Ile Tyr Ala Pro Lys Leu Gln 
        195                 200                 205             


Glu Phe Ala Tyr Val Thr Asp Gly Ala Cys Ser Glu Glu Asp Ile Leu 
    210                 215                 220                 


Arg Met Glu Leu Ile Ile Leu Lys Ala Leu Lys Trp Glu Leu Cys Pro 
225                 230                 235                 240 


Val Thr Ile Ile Ser Trp Leu Asn Leu Phe Leu Gln Val Asp Ala Leu 
                245                 250                 255     


Lys Asp Ala Pro Lys Val Leu Leu Pro Gln Tyr Ser Gln Glu Thr Phe 
            260                 265                 270         


Ile Gln Ile Ala Gln Leu Leu Asp Leu Cys Ile Leu Ala Ile Asp Ser 
        275                 280                 285             


Leu Glu Phe Gln Tyr Arg Ile Leu Thr Ala Ala Ala Leu Cys His Phe 
    290                 295                 300                 


Thr Ser Ile Glu Val Val Lys Lys Ala Ser Gly Leu Glu Trp Asp Ser 
305                 310                 315                 320 


Ile Ser Glu Cys Val Asp Trp Met Val Pro Phe Val Asn Val Val Lys 
                325                 330                 335     


Ser Thr Ser Pro Val Lys Leu Lys Thr Phe Lys Lys Ile Pro Met Glu 
            340                 345                 350         


Asp Arg His Asn Ile Gln Thr His Thr Asn Tyr Leu Ala Met Leu Cys 
        355                 360                 365             


Met Ile Ser Ser His Val 
    370                 


<210>  3
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Glu Glu Val Asn Tyr Ile Asn Thr Phe Arg Lys Gly Gly Gln Leu 
1               5                   10                  15      


Ser Pro Val Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser Thr Glu 
            20                  25                  30          


Lys Pro Pro Gly Lys His 
        35              


<210>  4
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  4

Glu Glu Val Asn Tyr Ile Asn Thr Phe Arg Lys Gly Gly Gln Leu Ser 
1               5                   10                  15      


Pro Val Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser Thr Glu Lys 
            20                  25                  30          


Pro Pro Gly Lys His 
        35          


<210>  5
<211>  19
<212>  PRT
<213>  Homo sapiens

<400>  5

Cys Asn Gly Gly Ile Met Thr Pro Pro Lys Ser Thr Glu Lys Pro Pro 
1               5                   10                  15      


Gly Lys His 
            


<210>  6
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  6

Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp Met 
1               5                   10                  15      


Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser Asp 
            20                  25                  30          


Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly Pro 
        35                  40                  45              


Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg Glu Asn Ile 
    50                  55                  60                  


Gln Arg Phe Phe Gly His Asp Ala Glu Asp Ser Leu Ala Asp Gln Ala 
65                  70                  75                  80  


Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg Pro 
                85                  90                  95      


Ala Gly Leu Pro Glu Lys Tyr 
            100             


<210>  7
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  7

Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp Met 
1               5                   10                  15      


Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser Asp 
            20                  25                  30          


Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly Pro 
        35                  40                  45              


Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg Glu Asn Ile 
    50                  55                  60                  


Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala Asp Gln Ala 
65                  70                  75                  80  


Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg Pro 
                85                  90                  95      


Ala Gly Leu Pro Glu Lys Tyr 
            100             


<210>  8
<211>  79
<212>  PRT
<213>  Homo sapiens

<400>  8

Ser Glu Ala Glu Asp Ala Ser Leu Leu Ser Phe Met Gln Gly Tyr Met 
1               5                   10                  15      


Lys His Ala Thr Lys Thr Ala Lys Asp Ala Leu Ser Ser Val Gln Glu 
            20                  25                  30          


Ser Gln Val Ala Gln Gln Ala Arg Gly Trp Val Thr Asp Gly Phe Ser 
        35                  40                  45              


Ser Leu Lys Asp Tyr Trp Ser Thr Val Lys Asp Lys Phe Ser Glu Phe 
    50                  55                  60                  


Trp Asp Leu Asp Pro Glu Val Arg Pro Thr Ser Ala Val Ala Ala 
65                  70                  75                  


<210>  9
<211>  42
<212>  PRT
<213>  Homo sapiens

<400>  9

Leu Glu Ala Ile Pro Met Ser Ile Pro Pro Glu Val Lys Phe Asn Glu 
1               5                   10                  15      


Pro Phe Val Phe Leu Met Ile Asp Gln Asn Thr Lys Ser Pro Leu Phe 
            20                  25                  30          


Met Gly Lys Val Val Asn Pro Thr Gln Lys 
        35                  40          


<210>  10
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Ala His Lys Ser Glu Val Ala His Arg Phe Lys Asp Leu Gly Glu 
1               5                   10                  15      


Glu Asn Phe Lys Ala Leu Val Leu 
            20                  



        


