                         SEQUENCE LISTING

<110>  NatImmune A/S
 
<120>  COU-1 binding member

<130>  P1500PC00

<160>  73    

<170>  PatentIn version 3.4

<210>  1
<211>  1309
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VH2


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  n is a, c, g, or t

<220>
<221>  CDS
<222>  (272)..(637)
<223>  variable domain heavy chain 2

<220>
<221>  misc_feature
<222>  (998)..(998)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1000)..(1000)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1003)..(1003)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1049)..(1051)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1067)..(1067)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1072)..(1072)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1084)..(1084)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1088)..(1088)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1090)..(1090)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1100)..(1100)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1107)..(1107)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1111)..(1111)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1113)..(1113)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1117)..(1117)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1141)..(1141)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1166)..(1166)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1172)..(1172)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1176)..(1176)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1189)..(1189)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1191)..(1191)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1210)..(1211)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1246)..(1246)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1251)..(1251)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1255)..(1256)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1258)..(1259)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1261)..(1261)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1274)..(1274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1280)..(1282)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1294)..(1296)
<223>  n is a, c, g, or t

<400>  1
tnnanaccat actatagggc gaattgggcc ctctagatgc atgctcgagc ggccgccagt     60

gtgatggata tctgcagaat tcgcccttct aatacgactc actatagggc aagcagtggt    120

atcaacgcag agtacgcggg ggggagacga gcccagcact ggaagtcgcc ggtgtttcca    180

ttcggtgatc agcactgaac acagaggact caccatggag tttgggctga gctgggtttt    240

cctcgttgct cttttaagag gtgtccagtg t cag gtg cag ctg gtg gaa tct       292
                                   Gln Val Gln Leu Val Glu Ser          
                                   1               5                    

ggg gga ggc gtg gtc cag cct ggg agg tcc ctg aga ctc tcc tgt gca      340
Gly Gly Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala         
        10                  15                  20                      

gcc tct gga ttc acc ttc agt aac tat gct ttg cac tgg gtc cgc cag      388
Ala Ser Gly Phe Thr Phe Ser Asn Tyr Ala Leu His Trp Val Arg Gln         
    25                  30                  35                          

gct cca ggc aag ggg ctg gag tgg gtg gca ctt ata tca tat gat gga      436
Ala Pro Gly Lys Gly Leu Glu Trp Val Ala Leu Ile Ser Tyr Asp Gly         
40                  45                  50                  55          

agt aat aaa tac tac gca gac tcc gtg aag ggc cga ttc acc atc tcc      484
Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser         
                60                  65                  70              

aga gac aat tcc aag aac acg ctg ttt ctg caa atg aat agc ctg aga      532
Arg Asp Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg         
            75                  80                  85                  

gct gag gac acg gct gtg tat tac tgt gcg aga gat aaa ggc tat agt      580
Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Lys Gly Tyr Ser         
        90                  95                  100                     

ggg agc tac aac tac ttt gac tac tgg ggc cag gga acc ctg gtc acc      628
Gly Ser Tyr Asn Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr         
    105                 110                 115                         

gtc tcc tca gggagtgcat ccgccccaac ccttttcccc ctcgtctcct              677
Val Ser Ser                                                             
120                                                                     

gtgagaattc cccgtcggat acgagcagcg tggccgttgg ctgcctcgca caggacttcc    737

ttcccgactc catcactttc tcctggaaat acaagaacaa ctctgacatc agcagcaccc    797

ggggcttccc atcagtcctg agagggggca agtacgcagc cacctcacag gtgctgctgc    857

cttccaagga cgtcatgcag ggcacggacg aacacgtggt gtgcaaagtc ccagcaaccc    917

ccaacggcaa caaagaaaag aacgtgcctc ttccaaaggg cgaatttcca gcacactggc    977

ggcccgttac tagtggatcc nangcncggt acccaagctt ggcgtaaatc atgggtcata   1037

gcttgtttcc tnnngtgaaa ttgttatccn gctcncattt cccccanaaa nanaacgagc   1097

cgnaagcctn aagngnaaan ccctgggggt gccttatgag tgancctaac ttccatttat   1157

tggctttgnc cttcnctgnc ccgcttttcc antncggaaa acctgtcggg ccnntttgct   1217

ttatgaaatc gcccaacccc cggggaaang cggnttgnnt nntnggggct ttttccnttt   1277

tcnnnttaaa tgaaatnnnt ggcctctggg tg                                 1309


<210>  2
<211>  122
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Leu His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Leu Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Lys Gly Tyr Ser Gly Ser Tyr Asn Tyr Phe Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  3
<211>  1406
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VL2


<220>
<221>  misc_feature
<222>  (2)..(3)
<223>  n is a, c, g, or t

<220>
<221>  CDS
<222>  (191)..(517)
<223>  variable domain light chain 2

<220>
<221>  misc_feature
<222>  (949)..(949)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1000)..(1000)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1024)..(1025)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1038)..(1038)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1049)..(1049)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1066)..(1066)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1078)..(1078)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1086)..(1086)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1108)..(1108)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1114)..(1114)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1138)..(1138)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1141)..(1141)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1148)..(1148)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1157)..(1157)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1163)..(1163)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1166)..(1166)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1173)..(1173)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1192)..(1194)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1202)..(1203)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1207)..(1207)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1217)..(1217)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1219)..(1220)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1233)..(1233)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1240)..(1240)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1247)..(1247)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1251)..(1252)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1255)..(1256)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1264)..(1264)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1269)..(1269)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1278)..(1278)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1287)..(1287)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1297)..(1297)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1310)..(1310)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1322)..(1322)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1324)..(1324)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1330)..(1330)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1341)..(1342)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1352)..(1352)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1358)..(1358)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1366)..(1366)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1374)..(1374)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1378)..(1379)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1384)..(1384)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1395)..(1395)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1401)..(1401)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1403)..(1403)
<223>  n is a, c, g, or t

<400>  3
gnnatcgact actatagggc gaattgggcc ctctagatgc atgctcgagc cggccgccag     60

tgtgatggat atctgcagaa ttcgccctta agcagtggta tcaacgcaga gtacgcgggg    120

agagggaacc atggaaaccc cagcgcagct tctcttcctc ctgctactct ggctcccaga    180

taccaccgga gaa att gtg ttg acg cag tct cca ggc acc ctg tct ttg       229
           Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu          
           1               5                   10                       

tct cca ggg gaa aga gcc acc ctc tcc tgc agg gcc agt cag agt gtt      277
Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val         
    15                  20                  25                          

agc agc agc tac tta gcc tgg tac cag cag aaa cct ggc cag gct ccc      325
Ser Ser Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro         
30                  35                  40                  45          

agg ctc ctc atc tat ggt gca tcc agc agg gcc act ggc atc cca gac      373
Arg Leu Leu Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp         
                50                  55                  60              

agg ttc agt ggc agt ggg tct ggg aca gac ttc act ctc acc atc agc      421
Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser         
            65                  70                  75                  

aga ctg gag cct gaa gat ttt gca atg tat tac tgt cag cag tat ggt      469
Arg Leu Glu Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr Gly         
        80                  85                  90                      

agc tca ccg tac act ttt ggc cag ggg acc aag ctg gag atc aaa cga      517
Ser Ser Pro Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg         
    95                  100                 105                         

actgtggctg caccatctgt cttcatcttc ccgccatctg atgagcagtt gaaatctgga    577

actgcctctg ttgtgtgcct gctgaataac ttctatccca gagaggccaa agtacagtgg    637

aaggtggata acgccctcca atcgggtaac tcccaggaga gtgtcacaga gcaggacagc    697

aaggacagca cctacagcct cagcagcacc ctgacgctga gcaaagcaga ctacgagaaa    757

cacaaagtct acgcctgcga agtcacccat cagggcctga gctcgcccgt cacaaagagc    817

ttcaacaggg gagagtgtaa gggcgaattc cagcacactg gcggccgtta ctagtggatc    877

cgagctcggt accaagcttg gcgtaatcat ggtcatagct gtttcctgtg tgaaattgtt    937

atccgctcac anttccacac aacatacgag cccggaagca taaaagtgta aaagcctggg    997

gtngcctaat gagtgagcta acctcanntt aatttgcgtt ngcgctcact gncccgcttt   1057

tccatttcng gaaaacctgt ngtgcccanc tgcatttaat gaatccggcc naacgcnccg   1117

ggggagaagg ccggttttgt nttnttgggc nctttttccn ctttcnttng ttaatngatt   1177

cgttggcctt tcggnnntcc gcttnngggn gaggggtttn annttacttc aaaggnggta   1237

atncgggttn cccnnaannc gggggtnaac cngggaaaaa ntttgttacn aaggcccccn   1297

aaggccggaa ccntaaaagg ccggntntgg ggntttttca aggnnccccc cccgngaaga   1357

ntttaaaant ccccttnttt nnggggntaa ctcccggntt ttantntcc               1406


<210>  4
<211>  109
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  4

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Tyr Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 


<210>  5
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VH2 CDR1


<220>
<221>  CDS
<222>  (1)..(15)

<400>  5
aac tat gct ttg cac                                                   15
Asn Tyr Ala Leu His                                                     
1               5                                                       


<210>  6
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  6

Asn Tyr Ala Leu His 
1               5   


<210>  7
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VH2 CDR2


<220>
<221>  CDS
<222>  (1)..(48)

<400>  7
ctt ata tca tat gat gga agt aat aaa tac tac gca gac tcc gtg aag       48
Leu Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys         
1               5                   10                  15              


<210>  8
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  8

Leu Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


<210>  9
<211>  39
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VH2 CDR3


<220>
<221>  CDS
<222>  (1)..(39)

<400>  9
gat aaa ggc tat agt ggg agc tac aac tac ttt gac tac                   39
Asp Lys Gly Tyr Ser Gly Ser Tyr Asn Tyr Phe Asp Tyr                     
1               5                   10                                  


<210>  10
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  10

Asp Lys Gly Tyr Ser Gly Ser Tyr Asn Tyr Phe Asp Tyr 
1               5                   10              


<210>  11
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VL2 CDR1


<220>
<221>  CDS
<222>  (1)..(36)

<400>  11
agg gcc agt cag agt gtt agc agc agc tac tta gcc                       36
Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala                         
1               5                   10                                  


<210>  12
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  12

Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  13
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VL2 CDR2


<220>
<221>  CDS
<222>  (1)..(21)

<400>  13
ggt gca tcc agc agg gcc act                                           21
Gly Ala Ser Ser Arg Ala Thr                                             
1               5                                                       


<210>  14
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  14

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  15
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VL2 CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  15
cag cag tat ggt agc tca ccg tac act                                   27
Gln Gln Tyr Gly Ser Ser Pro Tyr Thr                                     
1               5                                                       


<210>  16
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  16

Gln Gln Tyr Gly Ser Ser Pro Tyr Thr 
1               5                   


<210>  17
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH CDR 1 from Seq. ID No: 36

<400>  17

Ser Tyr Tyr Met His 
1               5   


<210>  18
<211>  16
<212>  PRT
<213>  artificial sequence 

<220>
<223>  VH CDR2 from Seq. ID No: 36

<400>  18

Ile Ile Asn Pro Ser Gly Gly Ser Thr Ser Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


<210>  19
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  VH CDR 3 from Seq. ID. No: 36

<400>  19

Asp Gln Val Val Val Ala Ala Thr Leu Ser Asn Tyr Gly Met Asp Val 
1               5                   10                  15      


<210>  20
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL CDR2 from Seq. ID No: 37

<400>  20

Asp Ala Ser Asn Arg Ala Thr 
1               5           


<210>  21
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL CDR 3 Seq. ID No: 37

<400>  21

Gln Gln Gly Thr Asn Trp Gly Ile Ala 
1               5                   


<210>  22
<211>  10
<212>  PRT
<213>  artificial sequence

<220>
<223>  VL CDR3 Seq. ID No: 38

<400>  22

Gln Gln Tyr Gly Asn Ser Pro Pro Tyr Thr 
1               5                   10  


<210>  23
<211>  1294
<212>  DNA
<213>  artificial sequence

<220>
<223>  Sequence of VH1


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (33)..(34)
<223>  n is a, c, g, or t

<220>
<221>  CDS
<222>  (257)..(625)
<223>  variable domain heavy chain 1

<220>
<221>  misc_feature
<222>  (967)..(967)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (969)..(969)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1005)..(1005)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1011)..(1011)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1017)..(1017)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1019)..(1019)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1021)..(1021)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1035)..(1035)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1050)..(1050)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1057)..(1057)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1062)..(1062)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1064)..(1064)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1071)..(1071)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1075)..(1075)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1091)..(1091)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1093)..(1093)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1095)..(1095)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1100)..(1100)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1103)..(1103)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1136)..(1136)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1145)..(1146)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1157)..(1157)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1166)..(1166)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1173)..(1173)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1180)..(1182)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1201)..(1201)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1203)..(1203)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1213)..(1213)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1215)..(1215)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1218)..(1219)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1222)..(1222)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1232)..(1233)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1235)..(1235)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1240)..(1240)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1242)..(1243)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1247)..(1247)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1252)..(1252)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1255)..(1255)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1260)..(1261)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1264)..(1264)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1267)..(1267)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1274)..(1274)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1276)..(1276)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1279)..(1280)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1283)..(1283)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1287)..(1287)
<223>  n is a, c, g, or t

<400>  23
ttatacantt attaggcgaa ttgggccctc tanngcatgc tcgagcggcc gccagtgtga     60

tggatatctg cagaattcgc ccttctaata cgactcacta tagggcaagc agtggtatca    120

acgcagagta cgcgggggag catcacccag caaccacatc tgtcctctag agaatcccct    180

gagagctccg ttcctcacca tggactggac ctggaggatc ctcttcttgg tggcagcagc    240

cacaggagcc cactcc cag gtg cag ctg gtg caa tct ggg gct gag gtg aag    292
                  Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys       
                  1               5                   10                

aag cct ggg gcc tca gtg aag gtc tcc tgc gag gct tct gga tac acc      340
Lys Pro Gly Ala Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr         
        15                  20                  25                      

ttc acc ggc cac tat atg cac tgg gtg cga cag gcc cct gga caa ggg      388
Phe Thr Gly His Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly         
    30                  35                  40                          

ctt gag tgg atg ggg tgg atc aac cct aac agt ggt ggc aca aac tat      436
Leu Glu Trp Met Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr         
45                  50                  55                  60          

gca cag aag ttt cag ggc agg gtc acc atc acc agg gac acg tcc atc      484
Ala Gln Lys Phe Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ile         
                65                  70                  75              

aac aca gcc tac atg gag ctg agc agg ctg aga tct gac gac acg gcc      532
Asn Thr Ala Tyr Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala         
            80                  85                  90                  

gtg tat tac tgt gcg aga gcc tca tat tgt ggt tat gac tgc tat tac      580
Val Tyr Tyr Cys Ala Arg Ala Ser Tyr Cys Gly Tyr Asp Cys Tyr Tyr         
        95                  100                 105                     

ttc ttt gac tac tgg ggc cag gga acc ctg gtc acc gtc tcc tcg          625
Phe Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser             
    110                 115                 120                         

gggagtgcat ccgccccaac ccttttcccc ctcgtctcct gtgagaattc cccgtcggat    685

acgagcagcg tggccgttgg ctgaagggcg aattccagca cactggcggc cgttactagt    745

ggatccgagc tcggtaccaa gcttggcgta atcatggtca tagctgtttc ctgtgtgaaa    805

ttgttatccg ctcacaattc cacacaacat acgagccgga agcataaagt gtaaagcctg    865

gggtgcctaa tgagtgagct aactcacatt aattgcgttg cgctcactgc ccgctttcca    925

gtcgggaaac ctgtcgtgcc agctgcatta atgaatcggc cnancgcgcg gggagaggcc    985

ggtttgcgta ttgggcgctn ttccgnttcc tngntnactg actcgctgcn ctcggtcgtt   1045

tcggntgcgg cnagcgntnt cagctnactn aaaaggcggt aatacngntn ttccncanaa   1105

tcaggggata acccaggaaa aaacatgtga ncaaaagccn nccaaaaggc cnggaaccct   1165

naaaaggncc cgttnnntgg ggtttttttc ataggntncc ccccctgnan aannttnaaa   1225

aaattgnncn ttaantnnaa gnggggnaan ccccnnggnt tnaaaaaanc nggnnttncc   1285

cnggaaacc                                                           1294


<210>  24
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Glu Ala Ser Gly Tyr Thr Phe Thr Gly His 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Ile Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ala Ser Tyr Cys Gly Tyr Asp Cys Tyr Tyr Phe Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  25
<211>  1376
<212>  DNA
<213>  artificial sequence

<220>
<223>  sequence of VL1


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  n is a, c, g, or t

<220>
<221>  CDS
<222>  (229)..(570)
<223>  variable domain light chain 1

<220>
<221>  misc_feature
<222>  (914)..(914)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (973)..(973)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (981)..(981)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1001)..(1001)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1031)..(1031)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1036)..(1036)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1042)..(1042)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1044)..(1044)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1056)..(1056)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1058)..(1058)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1092)..(1092)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1110)..(1111)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1122)..(1122)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1128)..(1128)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1130)..(1130)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1132)..(1132)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1137)..(1138)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1140)..(1140)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1156)..(1156)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1168)..(1168)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1170)..(1170)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1174)..(1174)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1187)..(1187)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1191)..(1191)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1201)..(1201)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1203)..(1203)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1215)..(1215)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1224)..(1224)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1229)..(1229)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1237)..(1237)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1239)..(1239)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1242)..(1242)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1257)..(1257)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1261)..(1261)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1263)..(1264)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1277)..(1277)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1280)..(1280)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1283)..(1283)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1288)..(1288)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1292)..(1293)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1300)..(1300)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1307)..(1308)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1311)..(1311)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1317)..(1317)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1321)..(1321)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1326)..(1326)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1328)..(1328)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1331)..(1331)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1337)..(1337)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1344)..(1344)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1351)..(1351)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1362)..(1363)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1365)..(1365)
<223>  n is a, c, g, or t

<220>
<221>  misc_feature
<222>  (1376)..(1376)
<223>  n is a, c, g, or t

<400>  25
ataaacanta nttagggcga attgggccct ctanagcatg ctcgagcggc cgccagtgtg     60

atggatatct gcagaattcg cccttctaat acgactcact atagggcaag cagtggtatc    120

aacgcagagt acgcggggga gctacaacag gcaggcaggg gcagcaagat ggtgttgcag    180

acccaggtct tcatttctct gttgctctgg atctctggtg cctacggg gac atc gtg     237
                                                     Asp Ile Val        
                                                     1                  

atg acc cag tct cca gac tcc ctg gct gtg tct ctg ggc gag agg gcc      285
Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly Glu Arg Ala         
    5                   10                  15                          

acc atc aac tgc aag tcc agc cag agt ctt tta tac agc tcc aac aat      333
Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Asn         
20                  25                  30                  35          

aag aac tac tta gct tgg tac cag cag aaa cca gga cag cct cct aag      381
Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys         
                40                  45                  50              

ttg ctc att tac tgg gca tct acc cgg gaa tcc ggg gtc cct gac cga      429
Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val Pro Asp Arg         
            55                  60                  65                  

ttc agt ggc agc ggg tct ggg aca gat ttc act ctc acc atc agc agc      477
Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser         
        70                  75                  80                      

ctg cag gct gaa gat gtg gca gtt tat tac tgt cag caa tat tat agt      525
Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Tyr Tyr Ser         
    85                  90                  95                          

act cct ccg atg ttc ggc caa ggg acc aag gtg gaa atc aaa cga          570
Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg             
100                 105                 110                             

actgtggctg caccatctgt caagggcgaa ttccagcaca ctggcggccg ttactagtgg    630

atccgagctc ggtaccaagc ttggcgtaat catggtcata gctgtttcct gtgtgaaatt    690

gttatccgct cacaattcca cacaacatac gagccggaag cataaagtgt aaagcctggg    750

gtgcctaatg agtgagctaa ctcacattaa ttgcgttgcg ctcactgccc gctttccagt    810

cgggaaacct gtcgtgccag ctgcattaat gaatcggcca acgcgcgggg agaggcgggt    870

ttgcgtattg ggcgctcttt ccgcttcctc gctcactgac tcgntgcgct cggtcgttcg    930

gctgcggcga gcggtatcag ctcactcaaa aggcggtaat acngttatcc ncagaatcag    990

gggataaccc naggaaaaaa catgtgagca aaaggccagc naaaanggcc angnaaccgt   1050

aaaaangncc gggttgctgg cgttttttcc ataaggcctc cncccccctg acgggcatcn   1110

naaaaatcga cncttaantn anaaggnngn gaaaaccccg ccaggnactt taaaaaancn   1170

aggngttttc cccctgnaaa nctccctctg ngncctttct tgttnccacc ctgnccctna   1230

ccggaancng gncccccttt ttccttnggg nanngggggc ttttttnaan ctnacccngg   1290

gnntttcaan tcggggnngg ngttccncaa nggggntngg nccaaanccc cttnaacccc   1350

nccgggcttt tnngnaaatt ttttgn                                        1376


<210>  26
<211>  114
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  26

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Ser Asn Asn Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln 
        35                  40                  45              


Pro Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln 
                85                  90                  95      


Tyr Tyr Ser Thr Pro Pro Met Phe Gly Gln Gly Thr Lys Val Glu Ile 
            100                 105                 110         


Lys Arg 
        


<210>  27
<211>  15
<212>  DNA
<213>  artificial sequence

<220>
<223>  VH1 CDR 1


<220>
<221>  CDS
<222>  (1)..(15)

<400>  27
ggc cac tat atg cac                                                   15
Gly His Tyr Met His                                                     
1               5                                                       


<210>  28
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  28

Gly His Tyr Met His 
1               5   


<210>  29
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  VH1 CDR2


<220>
<221>  CDS
<222>  (1)..(48)

<400>  29
tgg atc aac cct aac agt ggt ggc aca aac tat gca cag aag ttt cag       48
Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln         
1               5                   10                  15              


<210>  30
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  30

Trp Ile Asn Pro Asn Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


<210>  31
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  VH1 CDR 3


<220>
<221>  CDS
<222>  (1)..(42)

<400>  31
gcc tca tat tgt ggt tat gac tgc tat tac ttc ttt gac tac               42
Ala Ser Tyr Cys Gly Tyr Asp Cys Tyr Tyr Phe Phe Asp Tyr                 
1               5                   10                                  


<210>  32
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  32

Ala Ser Tyr Cys Gly Tyr Asp Cys Tyr Tyr Phe Phe Asp Tyr 
1               5                   10                  


<210>  33
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  VL1 CDR1


<220>
<221>  CDS
<222>  (1)..(48)
<223>  VL 1 CDR1

<400>  33
aag tcc agc cag agt ctt tta tac agc tcc aac aat aag aac tac tta       48
Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu         
1               5                   10                  15              


<210>  34
<211>  16
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  34

Lys Ser Ser Gln Ser Leu Leu Tyr Ser Ser Asn Asn Lys Asn Tyr Leu 
1               5                   10                  15      


<210>  35
<211>  21
<212>  DNA
<213>  artificial sequence

<220>
<223>  VL1 CDR2


<220>
<221>  CDS
<222>  (1)..(21)
<223>  VL1 CDR 2

<400>  35
tgg gca tct acc cgg gaa tcc                                           21
Trp Ala Ser Thr Arg Glu Ser                                             
1               5                                                       


<210>  36
<211>  7
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  36

Trp Ala Ser Thr Arg Glu Ser 
1               5           


<210>  37
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  VL1 CDR3


<220>
<221>  CDS
<222>  (1)..(27)

<400>  37
cag caa tat tat agt act cct ccg atg                                   27
Gln Gln Tyr Tyr Ser Thr Pro Pro Met                                     
1               5                                                       


<210>  38
<211>  9
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  38

Gln Gln Tyr Tyr Ser Thr Pro Pro Met 
1               5                   


<210>  39
<211>  47
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (3)..(47)

<400>  39
tg ctg gca gct cag ccg gcc atg gcc cag gtg cag ctg gtg caa tct        47
   Leu Ala Ala Gln Pro Ala Met Ala Gln Val Gln Leu Val Gln Ser          
   1               5                   10                  15           


<210>  40
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  40

Leu Ala Ala Gln Pro Ala Met Ala Gln Val Gln Leu Val Gln Ser 
1               5                   10                  15  


<210>  41
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  41
tggggcggat gcactccctg aaagcttcga ggagacggtg accagggt                  48


<210>  42
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (1)..(42)

<400>  42
acc ctg gtc acc gtc tcc tcg aag ctt tca ggg agt gca tcc gcccca        48
Thr Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser                 
1               5                   10                                  


<210>  43
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  43

Thr Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
1               5                   10                  


<210>  44
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (1)..(42)

<400>  44
gaa ggt gaa ttt tca gaa gca cgc gta gac atg gtg atg acc cagtct        48
Glu Gly Glu Phe Ser Glu Ala Arg Val Asp Met Val Met Thr                 
1               5                   10                                  


<210>  45
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  45

Glu Gly Glu Phe Ser Glu Ala Arg Val Asp Met Val Met Thr 
1               5                   10                  


<210>  46
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  46
gcttttgttc ggatccagcg gccgcacctc gtttgatttc caccttggt                 49


<210>  47
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (1)..(42)

<400>  47
acc aag gtg gaa atc aaa cga ggt gcg gcc gct gga tcc gaa caaaagc       49
Thr Lys Val Glu Ile Lys Arg Gly Ala Ala Ala Gly Ser Glu                 
1               5                   10                                  


<210>  48
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  48

Thr Lys Val Glu Ile Lys Arg Gly Ala Ala Ala Gly Ser Glu 
1               5                   10                  


<210>  49
<211>  47
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (3)..(47)

<400>  49
tg ctg gca gct cag ccg gcc atg gcc cag gtg cag ctg gtg gaa tct        47
   Leu Ala Ala Gln Pro Ala Met Ala Gln Val Gln Leu Val Glu Ser          
   1               5                   10                  15           


<210>  50
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  50

Leu Ala Ala Gln Pro Ala Met Ala Gln Val Gln Leu Val Glu Ser 
1               5                   10                  15  


<210>  51
<211>  48
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  51
tggggcggat gcactccctg aaagctttga ggagacggtg accagggt                  48


<210>  52
<211>  48
<212>  DNA
<213>  artificial sequence 

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (1)..(42)

<400>  52
acc ctg gtc acc gtc tcc tca aag ctt tca ggg agt gca tcc gcccca        48
Thr Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser                 
1               5                   10                                  


<210>  53
<211>  14
<212>  PRT
<213>  artificial sequence 

<220>
<223>  Synthetic Construct

<400>  53

Thr Leu Val Thr Val Ser Ser Lys Leu Ser Gly Ser Ala Ser 
1               5                   10                  


<210>  54
<211>  50
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (7)..(48)

<400>  54
gaaggt gaa ttt tca gaa gca cgc gta gaa att gtg ttg acg cag tct cc     50
       Glu Phe Ser Glu Ala Arg Val Glu Ile Val Leu Thr Gln Ser          
       1               5                   10                           


<210>  55
<211>  14
<212>  PRT
<213>  artificial sequence

<220>
<223>  Synthetic Construct

<400>  55

Glu Phe Ser Glu Ala Arg Val Glu Ile Val Leu Thr Gln Ser 
1               5                   10                  


<210>  56
<211>  49
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  56
gcttttgttc ggatccagcg gccgcacctc gtttgatctc cagcttggt                 49


<210>  57
<211>  49
<212>  DNA
<213>  artificial sequence 

<220>
<223>  synthetic construct


<220>
<221>  CDS
<222>  (1)..(42)

<400>  57
acc aag ctg gag atc aaa cga ggt gcg gcc gct gga tcc gaa caaaagc       49
Thr Lys Leu Glu Ile Lys Arg Gly Ala Ala Ala Gly Ser Glu                 
1               5                   10                                  


<210>  58
<211>  14
<212>  PRT
<213>  artificial sequence 

<220>
<223>  Synthetic Construct

<400>  58

Thr Lys Leu Glu Ile Lys Arg Gly Ala Ala Ala Gly Ser Glu 
1               5                   10                  


<210>  59
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  59
ggcgaattca cggtcaacca gagcctg                                         27


<210>  60
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  60
gatctcggat cctcacttgg gcaggacgtc                                      30


<210>  61
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  61
ggcgaattct ccaccagctt caggggc                                         27


<210>  62
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  62
gctgcgaagc ttttaatgcc tcagaacttt ggtg                                 34


<210>  63
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic construct

<400>  63
ggcgaattct tcgcaaatac tgtggac                                         27


<210>  64
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  64
cattatataa gcttgccacc atggtgttgc agacccagg                            39


<210>  65
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  65
cattatataa gcttgccacc atggaaaccc cagcgcagc                            39


<210>  66
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  66
gcaagctcgc tcgagttaac actctcccct gttgaagc                             38


<210>  67
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  67
cgaactgtgg ctgcaccatc tgtcttcatc ttcccg                               36


<210>  68
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  68
cgggaagatg aagacagatg gtgcagccac agttcg                               36


<210>  69
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  69
gaatctatct agagccacca tggactggac ctggagg                              37


<210>  70
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  70
gaatctatct agagccacca tggagtttgg gctgagc                              37


<210>  71
<211>  37
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  71
atgaatatga agcggccgct cagtagcagg tgccagc                              37


<210>  72
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  72
ctgtgagaat tccccgtcgg atacgagcag c                                    31


<210>  73
<211>  31
<212>  DNA
<213>  Artificial sequence

<220>
<223>  synthetic construct

<400>  73
gctgctcgta tccgacgggg aattctcaca g                                    31


