
                                SEQUENCE LISTING

<110> The Regents of the University of California
      Salmon, Kirsty
      Roth, David
      Hatfield, G. Wesley
      Dou, Yimeng

<120> PENTOSE PHOSPHATE PATHWAY AND
  FERMENTATION ENZYME-ENCODING NUCLEOTIDE SEQUENCES WITH
  REFINED TRANSLATIONAL KINETICS AND METHODS OF MAKING SAME
  

<130> UCI005.016VPC

<150> 60/939200           
<151> 2007-05-21  

<150> 60/939197           
<151> 2007-05-21  

<150> 60/940642           
<151> 2007-05-29  

<150> 60/940785           
<151> 2007-05-30  

<160> 108

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 2037
<212> DNA
<213> S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(2037)

<400> 1
atg act caa ttc act gac att gat aag cta gcc gtc tcc acc ata aga   48
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                   10                  15
 
att ttg gct gtg gac acc gta tcc aag gcc aac tca ggt cac cca ggt   96
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
             20                  25                  30
 
gct cca ttg ggt agg tca cca gct gca cac gtt cta ggt gag tca aat   144
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
         35                  40                  45
 
gcg cat gaa ccc aac caa ccc aag act gga tca aca gag ata gat ttg   192
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
     50                  55                  60
 
tct tgt cta acg gtc acg cgg tcg ctt tgt tgt atc tat cta cat ttg   240
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
 65                  70                  75                  80
 
act ggt tac gat ctg tct att gaa gac ttg aaa cag ttc aga cag ttg   288
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                 85                  90                  95
 
ggt tcc aga aca cca ggt cat cct gaa ttt gag ttg cca ggt gtt gaa   336
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110
 
gtt act acc ggt cca tta ggt caa ggt atc tcc aac gct gtt ggt atg   384
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125
 
gcc atg gct caa gct aac ctg gac atg cca ctt aca aca agc cgg gca   432
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140
 
ttt acc ttg tct gac aac tac acc tat gtt ttc ttg ggt gac ggt tgt   480
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160
 
ttg caa gaa ggt att tct tca gaa gct tcc tcc ttg gct ggt cat ttg   528
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175
 
aaa ttg ggt aac ttg att gcc atc tac gat gac aac aag atc act atc   576
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190
 
gat ggt gct acc agt atc tca ttc gat gaa gat gtt gct aag aga tac   624
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205
 
gaa gcc tac ggt tgg gaa gtt ttg tac gta gaa aat ggt aac gaa gat   672
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220
 
cta gcc ggt att gcc aag gct att cgt caa cgt aag tta tcc aag gac   720
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240
 
aaa cca act ttc gat caa aat gac cac aac cat tgg tta cgg ttc ctt   768
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255
 
cga tcc ggc tct cac tct gtg cac ggt gcc cca ttg aaa gca gat gat   816
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270
 
gtt aaa caa cta aag agc aaa ttc ggt ttc aac cca gac aag tcc ttt   864
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285
 
gtt gtt cca caa gaa gtt tac gac cac tac caa aag aca att tta aag   912
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300
 
cca ggt gtc gaa gcc aac aac aag tgg aac aag ttg ttc agc gaa tac   960
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320
 
caa aag aaa ttc cca gaa tta ggt gct gaa ttg gct aga aga ttg agc   1008
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335
 
ggc caa cta ccc gca aat tgg gaa tct aag ttg cca act tac acc gcc   1056
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350
 
aag gac tct gcc gtg gcc act aga aaa tta tca gaa act gtt ctt gag   1104
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365
 
gat gtt tac aat caa ttg cca gag ttg att ggt ggt tct gcc gat ttg   1152
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380
 
gtt ctg ccg att tta aca cct tct aac ttg acc aga tgg aag gaa gcc   1200
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400
 
ctt agc ttc caa cct cct tct tcc ggt tca ggt aac tac tct ggt aga   1248
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415
 
tac att agg tac ggt att aga gaa cac gct atg ggt gcc ata atg aac   1296
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430
 
ggt att tca gct ttc ggt gcc aac tac aaa cca tac ggt ggt act ttc   1344
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445
 
ttg aac ttc gtt tct tat gct gct ggt gcc gtt aga ttg tcc gct ttg   1392
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460
 
tct ggc cac cca gtt att tgg gtt gct aca cat gac tct atc ggt gtc   1440
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480
 
ggt gaa gat ggt cca aca cat caa cct att gaa act tta gca cac ttc   1488
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495
 
aga tcc cta cca aac att caa gtt tgg aga cca gct gat ggt aac gaa   1536
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510
 
gtt tct gcc gcc tac aag aac tct tta gaa tcc aag cat act cca agt   1584
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525
 
atc att gct ttg tcc cca gac aaa act tgc cac aat tgg aag gta gct   1632
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540
 
ctt att gaa agc gct tct aag ggt ggt tac gta cta caa gat gtt gct   1680
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560
 
aac cca gat att att tta gtg gct act ggt tcc gaa gtg tct ttg agt   1728
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575
 
gtt gaa gct gct aag act ttg gcc gca aag aac atc aag gct cgt gtt   1776
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590
 
gtt tct cta cca gat ttc ttc act ttt gac aaa caa ccc cta gaa tac   1824
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605
 
aga cta tca gtc tta cca gac aac gtt cca atc atg tct gtt gaa gtt   1872
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620
 
ttg gct acc aca tgt tgg ggc aaa tac gct cat caa tcc ttc ggt att   1920
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640
 
gac aga ttt ggt gct ccg gta agg cac cag aag tct tca agt tct tcg   1968
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655
 
gtt tca ccc cag aag gtg ttg ctg aaa gag ctc aaa aga cca ttg cat   2016
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670
 
tct ata agg gtg aca agc taa                                       2037
Ser Ile Arg Val Thr Ser  *
        675
 

<210> 2
<211> 678
<212> PRT
<213> S. cerevisiae

<400> 2
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 3
<211> 2034
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(2034)

<400> 3
atg act caa ttt act gac att gat aaa tta gct gtt tca act att aga   48
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                   10                  15
 
att ttg gct gta gat aca gtt tca aaa gct aat tca ggt cat cca ggt   96
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
             20                  25                  30
 
gct cca ttg ggt agg tct cct gcc gct cat gtt ttg ggt gaa tct aat   144
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
         35                  40                  45
 
gca cat gaa cca aat caa cca aaa aca ggt tct aca gaa ata gat ttg   192
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
     50                  55                  60
 
tct tgt ttg act gtt act aga tct ttg tgt tgt att tat ttg cat ttg   240
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
 65                  70                  75                  80
 
act ggt tat gat ttg tct att gaa gat tta aaa caa ttt aga caa ttg   288
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                 85                  90                  95
 
ggt tct aga act cca ggt cat cca gaa ttt gaa ttg cca ggt gtt gaa   336
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110
 
gtt act act ggt cca ttg ggt caa gga att tct aat gct gtt ggt atg   384
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125
 
gct atg gca caa gct aat ttg gat atg cct ttg act act tct aga gct   432
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140
 
ttt act cta tct gat aat tat act tat gtt ttc ttg ggt gat ggt tgt   480
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160
 
ttg caa gag gga att tct tct gag gct tct tct ttg gct ggt cat tta   528
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175
 
aaa ttg ggt aat ttg att gct att tat gat gat aat aaa att act att   576
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190
 
gat ggt gca act tct att tct ttt gat gaa gat gtt gct aaa aga tat   624
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205
 
gag gct tat ggt tgg gaa gtt ttg tat gtt gaa aat ggt aat gaa gat   672
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220
 
ttg gct gga att gct aaa gct att agg caa aga aaa ttg tct aaa gat   720
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240
 
aaa cca act ttc gat caa aat gac cat aat cat tgg ttg aga ttt ttg   768
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255
 
aga tct ggt tct cat tct gtt cat ggt gct cct tta aaa gct gat gat   816
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270
 
gtt aaa caa tta aaa tct aaa ttc ggt ttt aat cca gat aaa tct ttt   864
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285
 
gta gtt cca caa gaa gtt tat gat cat tat cag aaa act att tta aaa   912
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300
 
cct ggt gtt gaa gct aat aat aaa tgg aat aaa ttg ttt tct gaa tat   960
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320
 
caa aag aag ttt cca gaa ttg gga gca gag ttg gct agg aga ttg tct   1008
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335
 
ggt caa tta cct gca aat tgg gaa tca aaa ttg cct act tat act gct   1056
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350
 
aaa gat tct gct gtt gcc act aga aaa ttg tct gaa act gtt ttg gaa   1104
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365
 
gat gtt tat aat caa ttg cca gag ttg att ggt gga tct gct gat tta   1152
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380
 
gtt ttg cca att ttg act cct tct aat ttg act aga tgg aaa gaa gct   1200
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400
 
cta tct ttt caa cca cca tca tct gga tct ggt aat tat tct ggt aga   1248
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415
 
tat att aga tat gga att aga gaa cat gct atg ggt gct att atg aat   1296
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430
 
gga att tct gct ttt gga gct aat tat aaa cct tat ggt ggt act ttt   1344
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445
 
cta aat ttt gta tct tat gct gct ggt gct gtt aga ttg tct gct ttg   1392
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460
 
tct ggt cat cct gta att tgg gtt gct aca cat gat tct att ggt gtt   1440
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480
 
ggt gaa gat ggt cct act cat caa cca att gaa act cta gct cat ttt   1488
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495
 
aga tct ttg cca aat ata caa gta tgg aga cca gct gac ggt aat gaa   1536
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510
 
gta tct gct gct tat aaa aat tct ttg gaa tct aaa cat act cca tct   1584
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525
 
att att gct ttg tca cca gat aaa act tgt cat aat tgg aaa gta gct   1632
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540
 
ttg att gaa tct gct tct aaa ggt ggt tat gtt ttg caa gat gta gct   1680
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560
 
aat cca gat ata att ttg gtt gcc act ggt tct gaa gtt tca ttg tct   1728
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575
 
gta gag gct gca aaa aca tta gct gct aaa aac att aag gct aga gtt   1776
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590
 
gtt tca ttg cca gat ttc ttt act ttt gat aaa caa cca ttg gaa tat   1824
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605
 
aga ttg tca gtt ttg cct gat aat gtt cca att atg tct gtt gaa gtt   1872
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620
 
ttg gca act act tgt tgg ggt aaa tat gct cat caa tct ttt gga att   1920
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640
 
gat aga ttc ggt gct cca gtt aga cat caa aaa tct tct tct tct tct   1968
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655
 
gtt tca cca caa aag gtt ttg cta aaa gaa tta aaa aga cca ttg cat   2016
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670
 
tct att aga gtt act tct                                           2034
Ser Ile Arg Val Thr Ser
        675
 

<210> 4
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 4
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 5
<211> 2056
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(2045)

<400> 5
tactcaagct t atg act caa ttt act gac att gat aaa tta gct gtt tca  50
             Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser
              1               5                   10
 
act att aga att ttg gct gta gat aca gtt tca aaa gct aat tca ggt   98
Thr Ile Arg Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly
     15                  20                  25
 
cat cca ggt gct cca ttg ggt agg tct cct gcc gct cat gtt ttg ggt   146
His Pro Gly Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly
 30                  35                  40                  45
 
gaa tct aat gca cat gaa cca aat caa cca aaa aca ggt tct aca gaa   194
Glu Ser Asn Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu
                 50                  55                  60
 
ata gat ttg tct tgt ttg act gtt act aga tct ttg tgt tgt att tat   242
Ile Asp Leu Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr
             65                  70                  75
 
ttg cat ttg act ggt tat gat ttg tct att gaa gat tta aaa caa ttt   290
Leu His Leu Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe
         80                  85                  90
 
aga caa ttg ggt tct aga act cca ggt cat cca gaa ttt gaa ttg cca   338
Arg Gln Leu Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro
     95                 100                 105
 
ggt gtt gaa gtt act act ggt cca ttg ggt caa gga att tct aat gct   386
Gly Val Glu Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala
110                 115                 120                 125
 
gtt ggt atg gct atg gca caa gct aat ttg gat atg cct ttg act act   434
Val Gly Met Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr
                130                 135                 140
 
tct aga gct ttt act cta tct gat aat tat act tat gtt ttc ttg ggt   482
Ser Arg Ala Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly
            145                 150                 155
 
gat ggt tgt ttg caa gag gga att tct tct gag gct tct tct ttg gct   530
Asp Gly Cys Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala
        160                 165                 170
 
ggt cat tta aaa ttg ggt aat ttg att gct att tat gat gat aat aaa   578
Gly His Leu Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys
    175                 180                 185
 
att act att gat ggt gca act tct att tct ttt gat gaa gat gtt gct   626
Ile Thr Ile Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala
190                 195                 200                 205
 
aaa aga tat gag gct tat ggt tgg gaa gtt ttg tat gtt gaa aat ggt   674
Lys Arg Tyr Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly
                210                 215                 220
 
aat gaa gat ttg gct gga att gct aaa gct att agg caa aga aaa ttg   722
Asn Glu Asp Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu
            225                 230                 235
 
tct aaa gat aaa cca act ttc gat caa aat gac cat aat cat tgg ttg   770
Ser Lys Asp Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu
        240                 245                 250
 
aga ttt ttg aga tct ggt tct cat tct gtt cat ggt gct cct tta aaa   818
Arg Phe Leu Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys
    255                 260                 265
 
gct gat gat gtt aaa caa tta aaa tct aaa ttc ggt ttt aat cca gat   866
Ala Asp Asp Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp
270                 275                 280                 285
 
aaa tct ttt gta gtt cca caa gaa gtt tat gat cat tat cag aaa act   914
Lys Ser Phe Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr
                290                 295                 300
 
att tta aaa cct ggt gtt gaa gct aat aat aaa tgg aat aaa ttg ttt   962
Ile Leu Lys Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe
            305                 310                 315
 
tct gaa tat caa aag aag ttt cca gaa ttg gga gca gag ttg gct agg   1010
Ser Glu Tyr Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg
        320                 325                 330
 
aga ttg tct ggt caa tta cct gca aat tgg gaa tca aaa ttg cct act   1058
Arg Leu Ser Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr
    335                 340                 345
 
tat act gct aaa gat tct gct gtt gcc act aga aaa ttg tct gaa act   1106
Tyr Thr Ala Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr
350                 355                 360                 365
 
gtt ttg gaa gat gtt tat aat caa ttg cca gag ttg att ggt gga tct   1154
Val Leu Glu Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser
                370                 375                 380
 
gct gat tta gtt ttg cca att ttg act cct tct aat ttg act aga tgg   1202
Ala Asp Leu Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp
            385                 390                 395
 
aaa gaa gct cta tct ttt caa cca cca tca tct gga tct ggt aat tat   1250
Lys Glu Ala Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr
        400                 405                 410
 
tct ggt aga tat att aga tat gga att aga gaa cat gct atg ggt gct   1298
Ser Gly Arg Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala
    415                 420                 425
 
att atg aat gga att tct gct ttt gga gct aat tat aaa cct tat ggt   1346
Ile Met Asn Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly
430                 435                 440                 445
 
ggt act ttt cta aat ttt gta tct tat gct gct ggt gct gtt aga ttg   1394
Gly Thr Phe Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu
                450                 455                 460
 
tct gct ttg tct ggt cat cct gta att tgg gtt gct aca cat gat tct   1442
Ser Ala Leu Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser
            465                 470                 475
 
att ggt gtt ggt gaa gat ggt cct act cat caa cca att gaa act cta   1490
Ile Gly Val Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu
        480                 485                 490
 
gct cat ttt aga tct ttg cca aat ata caa gta tgg aga cca gct gac   1538
Ala His Phe Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp
    495                 500                 505
 
ggt aat gaa gta tct gct gct tat aaa aat tct ttg gaa tct aaa cat   1586
Gly Asn Glu Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His
510                 515                 520                 525
 
act cca tct att att gct ttg tca cca gat aaa act tgt cat aat tgg   1634
Thr Pro Ser Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp
                530                 535                 540
 
aaa gta gct ttg att gaa tct gct tct aaa ggt ggt tat gtt ttg caa   1682
Lys Val Ala Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln
            545                 550                 555
 
gat gta gct aat cca gat ata att ttg gtt gcc act ggt tct gaa gtt   1730
Asp Val Ala Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val
        560                 565                 570
 
tca ttg tct gta gag gct gca aaa aca tta gct gct aaa aac att aag   1778
Ser Leu Ser Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys
    575                 580                 585
 
gct aga gtt gtt tca ttg cca gat ttc ttt act ttt gat aaa caa cca   1826
Ala Arg Val Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro
590                 595                 600                 605
 
ttg gaa tat aga ttg tca gtt ttg cct gat aat gtt cca att atg tct   1874
Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser
                610                 615                 620
 
gtt gaa gtt ttg gca act act tgt tgg ggt aaa tat gct cat caa tct   1922
Val Glu Val Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser
            625                 630                 635
 
ttt gga att gat aga ttc ggt gct cca gtt aga cat caa aaa tct tct   1970
Phe Gly Ile Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser
        640                 645                 650
 
tct tct tct gtt tca cca caa aag gtt ttg cta aaa gaa tta aaa aga   2018
Ser Ser Ser Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg
    655                 660                 665
 
cca ttg cat tct att aga gtt act tct gaattccgat g                  2056
Pro Leu His Ser Ile Arg Val Thr Ser
670                 675
 

<210> 6
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 6
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 7
<211> 2062
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(2048)

<400> 7
gaatactcca tatg atg act caa ttt act gac att gat aaa tta gct gtt   50
                Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val
                 1               5                   10
 
tca act att aga att ttg gct gta gat aca gtt tca aaa gct aat tca   98
Ser Thr Ile Arg Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser
         15                  20                  25
 
ggt cat cca ggt gct cca ttg ggt agg tct cct gcc gct cat gtt ttg   146
Gly His Pro Gly Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu
     30                  35                  40
 
ggt gaa tct aat gca cat gaa cca aat caa cca aaa aca ggt tct aca   194
Gly Glu Ser Asn Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr
 45                  50                  55                  60
 
gaa ata gat ttg tct tgt ttg act gtt act aga tct ttg tgt tgt att   242
Glu Ile Asp Leu Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile
                 65                  70                  75
 
tat ttg cat ttg act ggt tat gat ttg tct att gaa gat tta aaa caa   290
Tyr Leu His Leu Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln
             80                  85                  90
 
ttt aga caa ttg ggt tct aga act cca ggt cat cca gaa ttt gaa ttg   338
Phe Arg Gln Leu Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu
         95                 100                 105
 
cca ggt gtt gaa gtt act act ggt cca ttg ggt caa gga att tct aat   386
Pro Gly Val Glu Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn
    110                 115                 120
 
gct gtt ggt atg gct atg gca caa gct aat ttg gat atg cct ttg act   434
Ala Val Gly Met Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr
125                 130                 135                 140
 
act tct aga gct ttt act cta tct gat aat tat act tat gtt ttc ttg   482
Thr Ser Arg Ala Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu
                145                 150                 155
 
ggt gat ggt tgt ttg caa gag gga att tct tct gag gct tct tct ttg   530
Gly Asp Gly Cys Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu
            160                 165                 170
 
gct ggt cat tta aaa ttg ggt aat ttg att gct att tat gat gat aat   578
Ala Gly His Leu Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn
        175                 180                 185
 
aaa att act att gat ggt gca act tct att tct ttt gat gaa gat gtt   626
Lys Ile Thr Ile Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val
    190                 195                 200
 
gct aaa aga tat gag gct tat ggt tgg gaa gtt ttg tat gtt gaa aat   674
Ala Lys Arg Tyr Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn
205                 210                 215                 220
 
ggt aat gaa gat ttg gct gga att gct aaa gct att agg caa aga aaa   722
Gly Asn Glu Asp Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys
                225                 230                 235
 
ttg tct aaa gat aaa cca act ttc gat caa aat gac cat aat cat tgg   770
Leu Ser Lys Asp Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp
            240                 245                 250
 
ttg aga ttt ttg aga tct ggt tct cat tct gtt cat ggt gct cct tta   818
Leu Arg Phe Leu Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu
        255                 260                 265
 
aaa gct gat gat gtt aaa caa tta aaa tct aaa ttc ggt ttt aat cca   866
Lys Ala Asp Asp Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro
    270                 275                 280
 
gat aaa tct ttt gta gtt cca caa gaa gtt tat gat cat tat cag aaa   914
Asp Lys Ser Phe Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys
285                 290                 295                 300
 
act att tta aaa cct ggt gtt gaa gct aat aat aaa tgg aat aaa ttg   962
Thr Ile Leu Lys Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu
                305                 310                 315
 
ttt tct gaa tat caa aag aag ttt cca gaa ttg gga gca gag ttg gct   1010
Phe Ser Glu Tyr Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala
            320                 325                 330
 
agg aga ttg tct ggt caa tta cct gca aat tgg gaa tca aaa ttg cct   1058
Arg Arg Leu Ser Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro
        335                 340                 345
 
act tat act gct aaa gat tct gct gtt gcc act aga aaa ttg tct gaa   1106
Thr Tyr Thr Ala Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu
    350                 355                 360
 
act gtt ttg gaa gat gtt tat aat caa ttg cca gag ttg att ggt gga   1154
Thr Val Leu Glu Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly
365                 370                 375                 380
 
tct gct gat tta gtt ttg cca att ttg act cct tct aat ttg act aga   1202
Ser Ala Asp Leu Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg
                385                 390                 395
 
tgg aaa gaa gct cta tct ttt caa cca cca tca tct gga tct ggt aat   1250
Trp Lys Glu Ala Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn
            400                 405                 410
 
tat tct ggt aga tat att aga tat gga att aga gaa cat gct atg ggt   1298
Tyr Ser Gly Arg Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly
        415                 420                 425
 
gct att atg aat gga att tct gct ttt gga gct aat tat aaa cct tat   1346
Ala Ile Met Asn Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr
    430                 435                 440
 
ggt ggt act ttt cta aat ttt gta tct tat gct gct ggt gct gtt aga   1394
Gly Gly Thr Phe Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg
445                 450                 455                 460
 
ttg tct gct ttg tct ggt cat cct gta att tgg gtt gct aca cat gat   1442
Leu Ser Ala Leu Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp
                465                 470                 475
 
tct att ggt gtt ggt gaa gat ggt cct act cat caa cca att gaa act   1490
Ser Ile Gly Val Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr
            480                 485                 490
 
cta gct cat ttt aga tct ttg cca aat ata caa gta tgg aga cca gct   1538
Leu Ala His Phe Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala
        495                 500                 505
 
gac ggt aat gaa gta tct gct gct tat aaa aat tct ttg gaa tct aaa   1586
Asp Gly Asn Glu Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys
    510                 515                 520
 
cat act cca tct att att gct ttg tca cca gat aaa act tgt cat aat   1634
His Thr Pro Ser Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn
525                 530                 535                 540
 
tgg aaa gta gct ttg att gaa tct gct tct aaa ggt ggt tat gtt ttg   1682
Trp Lys Val Ala Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu
                545                 550                 555
 
caa gat gta gct aat cca gat ata att ttg gtt gcc act ggt tct gaa   1730
Gln Asp Val Ala Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu
            560                 565                 570
 
gtt tca ttg tct gta gag gct gca aaa aca tta gct gct aaa aac att   1778
Val Ser Leu Ser Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile
        575                 580                 585
 
aag gct aga gtt gtt tca ttg cca gat ttc ttt act ttt gat aaa caa   1826
Lys Ala Arg Val Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln
    590                 595                 600
 
cca ttg gaa tat aga ttg tca gtt ttg cct gat aat gtt cca att atg   1874
Pro Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met
605                 610                 615                 620
 
tct gtt gaa gtt ttg gca act act tgt tgg ggt aaa tat gct cat caa   1922
Ser Val Glu Val Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln
                625                 630                 635
 
tct ttt gga att gat aga ttc ggt gct cca gtt aga cat caa aaa tct   1970
Ser Phe Gly Ile Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser
            640                 645                 650
 
tct tct tct tct gtt tca cca caa aag gtt ttg cta aaa gaa tta aaa   2018
Ser Ser Ser Ser Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys
        655                 660                 665
 
aga cca ttg cat tct att aga gtt act tct actagtcgat gcct           2062
Arg Pro Leu His Ser Ile Arg Val Thr Ser
    670                 675
 

<210> 8
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 8
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 9
<211> 2034
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(2034)

<400> 9
atg acc cag ttc acc gac att gac aaa ctc gcg gtt agc acc atc cgt   48
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                   10                  15
 
atc ctg gct gtt gac acc gtt agc aaa gct aat tcc ggt cat cca ggt   96
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
             20                  25                  30
 
gcg cca ctg ggt cgt tcc ccg gcg gct cat gtt ctg ggt gaa tct aac   144
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
         35                  40                  45
 
gcg cac gaa ccg aac cag ccg aaa acc ggt tct acc gaa att gac ctg   192
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
     50                  55                  60
 
tct tgc ctg act gtt acc cgt tct ctg tgc tgc atc tac ctg cac ctg   240
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
 65                  70                  75                  80
 
acc ggt tac gac ctg tct atc gaa gac ctg aaa cag ttt cgt cag ctg   288
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                 85                  90                  95
 
ggt tct cgt acc cca ggt cat ccg gaa ttt gaa ctg cca ggt gtt gaa   336
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110
 
gtt acc acc ggt ccg ctt ggt cag ggt atc tct aac gct gtt ggt atg   384
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125
 
gct atg gct cag gct aat ctg gac atg ccg ctg acc acc tct cgt gcg   432
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140
 
ttc acc ctg tct gac aac tac acc tac gtt ttc ctg ggt gac ggt tgc   480
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160
 
ctc caa gaa ggt atc tct tct gaa gct agc tct ctg gct ggt cac ctg   528
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175
 
aaa ctg ggt aac ctg atc gcg att tac gac gac aac aaa atc acc att   576
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190
 
gac ggt gcg acc tct atc tct ttc gac gaa gac gtt gcg aag cgt tac   624
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205
 
gag gcg tac ggt tgg gaa gtt ctg tac gta gaa aac ggt aac gaa gac   672
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220
 
ctg gct ggt atc gcg aaa gct atc cgt cag cgt aaa ctg tct aaa gac   720
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240
 
aaa ccg acc ttc gac cag aac gac cac aac cat tgg ctg cgt ttc ctg   768
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255
 
cgt tct ggc tct cac tct gtt cac ggt gct ccg ctg aaa gct gat gac   816
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270
 
gtt aaa cag ctg aaa tct aaa ttc ggt ttc aac ccg gac aaa tct ttc   864
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285
 
gtt gtt ccg cag gag gtt tac gac cat tac cag aaa acc atc ctg aaa   912
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300
 
ccg ggt gtt gag gcg aac aac aaa tgg aac aaa ctg ttc tct gaa tac   960
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320
 
cag aaa aag ttc cct gaa ctg ggt gcg gaa ctg gct cgt cgt ctg tct   1008
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335
 
ggt cag ctg ccg gcg aat tgg gaa tct aaa ctg cca acc tac acc gcg   1056
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350
 
aaa gac tct gct gtt gcg acc cgt aaa ctg tct gaa acc gtt ctc gaa   1104
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365
 
gac gtt tac aac cag ctc cca gaa ctg atc ggt ggt tct gcg gac ctg   1152
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380
 
gtt ctg ccg atc ctg acc ccg tct aac ctg acc cgt tgg aaa gaa gct   1200
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400
 
ctg tct ttt cag ccg ccg tct tct ggt tct ggt aac tac tct ggt cgt   1248
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415
 
tac atc cgt tac ggt atc cgc gaa cac gct atg ggt gcg atc atg aac   1296
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430
 
ggt atc tct gcc ttc ggt gcg aac tac aaa ccg tat ggc ggc acc ttc   1344
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445
 
ctg aac ttc gtt agc tac gcg gcg ggt gca gtt cgt ctg tct gct ctg   1392
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460
 
tct ggt cat ccg gtt att tgg gtt gcg acg cac gac tct atc ggt gtt   1440
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480
 
ggt gaa gac ggt ccg acc cac cag ccg atc gaa acc ctc gcg cac ttt   1488
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495
 
cgt tct ctg ccg aac atc cag gtg tgg cgt cca gct gat ggc aac gaa   1536
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510
 
gtt agc gcg gcg tac aaa aac tct ctc gaa tct aaa cac acc ccg tct   1584
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525
 
atc atc gcg ctc agc ccg gac aaa acc tgc cac aat tgg aaa gtt gct   1632
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540
 
ctg atc gaa tct gcg tct aaa ggt ggc tac gtt ctc caa gat gta gcg   1680
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560
 
aac ccg gac atc atc ctg gta gcg acc ggt tct gaa gtt agc ctg tct   1728
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575
 
gtt gag gcg gcg aaa acc ctg gct gcg aaa aac atc aag gcg cgt gtt   1776
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590
 
gtt agc ctg ccg gac ttc ttc acc ttc gac aaa cag ccg ctc gaa tac   1824
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605
 
cgt ctt agc gtt ctg cct gat aac gtt cct atc atg tct gtt gaa gtt   1872
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620
 
ctg gct acc acc tgc tgg ggt aaa tac gcg cac cag tct ttc ggt att   1920
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640
 
gat cgt ttc ggt gcc cca gtt cgt cac cag aaa tct tct tct tct tct   1968
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655
 
gtt agc ccg cag aaa gtt ctg ttg aaa gaa ctg aaa cgt ccg ctg cac   2016
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670
 
tct atc cgt gtt acc tct                                           2034
Ser Ile Arg Val Thr Ser
        675
 

<210> 10
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 10
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 11
<211> 2056
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(2045)

<400> 11
tactcaagct t atg acc cag ttc acc gac att gac aaa ctc gcg gtt agc  50
             Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser
              1               5                   10
 
acc atc cgt atc ctg gct gtt gac acc gtt agc aaa gct aat tcc ggt   98
Thr Ile Arg Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly
     15                  20                  25
 
cat cca ggt gcg cca ctg ggt cgt tcc ccg gcg gct cat gtt ctg ggt   146
His Pro Gly Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly
 30                  35                  40                  45
 
gaa tct aac gcg cac gaa ccg aac cag ccg aaa acc ggt tct acc gaa   194
Glu Ser Asn Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu
                 50                  55                  60
 
att gac ctg tct tgc ctg act gtt acc cgt tct ctg tgc tgc atc tac   242
Ile Asp Leu Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr
             65                  70                  75
 
ctg cac ctg acc ggt tac gac ctg tct atc gaa gac ctg aaa cag ttt   290
Leu His Leu Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe
         80                  85                  90
 
cgt cag ctg ggt tct cgt acc cca ggt cat ccg gaa ttt gaa ctg cca   338
Arg Gln Leu Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro
     95                 100                 105
 
ggt gtt gaa gtt acc acc ggt ccg ctt ggt cag ggt atc tct aac gct   386
Gly Val Glu Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala
110                 115                 120                 125
 
gtt ggt atg gct atg gct cag gct aat ctg gac atg ccg ctg acc acc   434
Val Gly Met Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr
                130                 135                 140
 
tct cgt gcg ttc acc ctg tct gac aac tac acc tac gtt ttc ctg ggt   482
Ser Arg Ala Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly
            145                 150                 155
 
gac ggt tgc ctc caa gaa ggt atc tct tct gaa gct agc tct ctg gct   530
Asp Gly Cys Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala
        160                 165                 170
 
ggt cac ctg aaa ctg ggt aac ctg atc gcg att tac gac gac aac aaa   578
Gly His Leu Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys
    175                 180                 185
 
atc acc att gac ggt gcg acc tct atc tct ttc gac gaa gac gtt gcg   626
Ile Thr Ile Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala
190                 195                 200                 205
 
aag cgt tac gag gcg tac ggt tgg gaa gtt ctg tac gta gaa aac ggt   674
Lys Arg Tyr Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly
                210                 215                 220
 
aac gaa gac ctg gct ggt atc gcg aaa gct atc cgt cag cgt aaa ctg   722
Asn Glu Asp Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu
            225                 230                 235
 
tct aaa gac aaa ccg acc ttc gac cag aac gac cac aac cat tgg ctg   770
Ser Lys Asp Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu
        240                 245                 250
 
cgt ttc ctg cgt tct ggc tct cac tct gtt cac ggt gct ccg ctg aaa   818
Arg Phe Leu Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys
    255                 260                 265
 
gct gat gac gtt aaa cag ctg aaa tct aaa ttc ggt ttc aac ccg gac   866
Ala Asp Asp Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp
270                 275                 280                 285
 
aaa tct ttc gtt gtt ccg cag gag gtt tac gac cat tac cag aaa acc   914
Lys Ser Phe Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr
                290                 295                 300
 
atc ctg aaa ccg ggt gtt gag gcg aac aac aaa tgg aac aaa ctg ttc   962
Ile Leu Lys Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe
            305                 310                 315
 
tct gaa tac cag aaa aag ttc cct gaa ctg ggt gcg gaa ctg gct cgt   1010
Ser Glu Tyr Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg
        320                 325                 330
 
cgt ctg tct ggt cag ctg ccg gcg aat tgg gaa tct aaa ctg cca acc   1058
Arg Leu Ser Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr
    335                 340                 345
 
tac acc gcg aaa gac tct gct gtt gcg acc cgt aaa ctg tct gaa acc   1106
Tyr Thr Ala Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr
350                 355                 360                 365
 
gtt ctc gaa gac gtt tac aac cag ctc cca gaa ctg atc ggt ggt tct   1154
Val Leu Glu Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser
                370                 375                 380
 
gcg gac ctg gtt ctg ccg atc ctg acc ccg tct aac ctg acc cgt tgg   1202
Ala Asp Leu Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp
            385                 390                 395
 
aaa gaa gct ctg tct ttt cag ccg ccg tct tct ggt tct ggt aac tac   1250
Lys Glu Ala Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr
        400                 405                 410
 
tct ggt cgt tac atc cgt tac ggt atc cgc gaa cac gct atg ggt gcg   1298
Ser Gly Arg Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala
    415                 420                 425
 
atc atg aac ggt atc tct gcc ttc ggt gcg aac tac aaa ccg tat ggc   1346
Ile Met Asn Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly
430                 435                 440                 445
 
ggc acc ttc ctg aac ttc gtt agc tac gcg gcg ggt gca gtt cgt ctg   1394
Gly Thr Phe Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu
                450                 455                 460
 
tct gct ctg tct ggt cat ccg gtt att tgg gtt gcg acg cac gac tct   1442
Ser Ala Leu Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser
            465                 470                 475
 
atc ggt gtt ggt gaa gac ggt ccg acc cac cag ccg atc gaa acc ctc   1490
Ile Gly Val Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu
        480                 485                 490
 
gcg cac ttt cgt tct ctg ccg aac atc cag gtg tgg cgt cca gct gat   1538
Ala His Phe Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp
    495                 500                 505
 
ggc aac gaa gtt agc gcg gcg tac aaa aac tct ctc gaa tct aaa cac   1586
Gly Asn Glu Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His
510                 515                 520                 525
 
acc ccg tct atc atc gcg ctc agc ccg gac aaa acc tgc cac aat tgg   1634
Thr Pro Ser Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp
                530                 535                 540
 
aaa gtt gct ctg atc gaa tct gcg tct aaa ggt ggc tac gtt ctc caa   1682
Lys Val Ala Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln
            545                 550                 555
 
gat gta gcg aac ccg gac atc atc ctg gta gcg acc ggt tct gaa gtt   1730
Asp Val Ala Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val
        560                 565                 570
 
agc ctg tct gtt gag gcg gcg aaa acc ctg gct gcg aaa aac atc aag   1778
Ser Leu Ser Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys
    575                 580                 585
 
gcg cgt gtt gtt agc ctg ccg gac ttc ttc acc ttc gac aaa cag ccg   1826
Ala Arg Val Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro
590                 595                 600                 605
 
ctc gaa tac cgt ctt agc gtt ctg cct gat aac gtt cct atc atg tct   1874
Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser
                610                 615                 620
 
gtt gaa gtt ctg gct acc acc tgc tgg ggt aaa tac gcg cac cag tct   1922
Val Glu Val Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser
            625                 630                 635
 
ttc ggt att gat cgt ttc ggt gcc cca gtt cgt cac cag aaa tct tct   1970
Phe Gly Ile Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser
        640                 645                 650
 
tct tct tct gtt agc ccg cag aaa gtt ctg ttg aaa gaa ctg aaa cgt   2018
Ser Ser Ser Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg
    655                 660                 665
 
ccg ctg cac tct atc cgt gtt acc tct gaattccgat g                  2056
Pro Leu His Ser Ile Arg Val Thr Ser
670                 675
 

<210> 12
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 12
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 13
<211> 2062
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(2048)

<400> 13
gaatactcca tatg atg acc cag ttc acc gac att gac aaa ctc gcg gtt   50
                Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val
                 1               5                   10
 
agc acc atc cgt atc ctg gct gtt gac acc gtt agc aaa gct aat tcc   98
Ser Thr Ile Arg Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser
         15                  20                  25
 
ggt cat cca ggt gcg cca ctg ggt cgt tcc ccg gcg gct cat gtt ctg   146
Gly His Pro Gly Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu
     30                  35                  40
 
ggt gaa tct aac gcg cac gaa ccg aac cag ccg aaa acc ggt tct acc   194
Gly Glu Ser Asn Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr
 45                  50                  55                  60
 
gaa att gac ctg tct tgc ctg act gtt acc cgt tct ctg tgc tgc atc   242
Glu Ile Asp Leu Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile
                 65                  70                  75
 
tac ctg cac ctg acc ggt tac gac ctg tct atc gaa gac ctg aaa cag   290
Tyr Leu His Leu Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln
             80                  85                  90
 
ttt cgt cag ctg ggt tct cgt acc cca ggt cat ccg gaa ttt gaa ctg   338
Phe Arg Gln Leu Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu
         95                 100                 105
 
cca ggt gtt gaa gtt acc acc ggt ccg ctt ggt cag ggt atc tct aac   386
Pro Gly Val Glu Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn
    110                 115                 120
 
gct gtt ggt atg gct atg gct cag gct aat ctg gac atg ccg ctg acc   434
Ala Val Gly Met Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr
125                 130                 135                 140
 
acc tct cgt gcg ttc acc ctg tct gac aac tac acc tac gtt ttc ctg   482
Thr Ser Arg Ala Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu
                145                 150                 155
 
ggt gac ggt tgc ctc caa gaa ggt atc tct tct gaa gct agc tct ctg   530
Gly Asp Gly Cys Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu
            160                 165                 170
 
gct ggt cac ctg aaa ctg ggt aac ctg atc gcg att tac gac gac aac   578
Ala Gly His Leu Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn
        175                 180                 185
 
aaa atc acc att gac ggt gcg acc tct atc tct ttc gac gaa gac gtt   626
Lys Ile Thr Ile Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val
    190                 195                 200
 
gcg aag cgt tac gag gcg tac ggt tgg gaa gtt ctg tac gta gaa aac   674
Ala Lys Arg Tyr Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn
205                 210                 215                 220
 
ggt aac gaa gac ctg gct ggt atc gcg aaa gct atc cgt cag cgt aaa   722
Gly Asn Glu Asp Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys
                225                 230                 235
 
ctg tct aaa gac aaa ccg acc ttc gac cag aac gac cac aac cat tgg   770
Leu Ser Lys Asp Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp
            240                 245                 250
 
ctg cgt ttc ctg cgt tct ggc tct cac tct gtt cac ggt gct ccg ctg   818
Leu Arg Phe Leu Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu
        255                 260                 265
 
aaa gct gat gac gtt aaa cag ctg aaa tct aaa ttc ggt ttc aac ccg   866
Lys Ala Asp Asp Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro
    270                 275                 280
 
gac aaa tct ttc gtt gtt ccg cag gag gtt tac gac cat tac cag aaa   914
Asp Lys Ser Phe Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys
285                 290                 295                 300
 
acc atc ctg aaa ccg ggt gtt gag gcg aac aac aaa tgg aac aaa ctg   962
Thr Ile Leu Lys Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu
                305                 310                 315
 
ttc tct gaa tac cag aaa aag ttc cct gaa ctg ggt gcg gaa ctg gct   1010
Phe Ser Glu Tyr Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala
            320                 325                 330
 
cgt cgt ctg tct ggt cag ctg ccg gcg aat tgg gaa tct aaa ctg cca   1058
Arg Arg Leu Ser Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro
        335                 340                 345
 
acc tac acc gcg aaa gac tct gct gtt gcg acc cgt aaa ctg tct gaa   1106
Thr Tyr Thr Ala Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu
    350                 355                 360
 
acc gtt ctc gaa gac gtt tac aac cag ctc cca gaa ctg atc ggt ggt   1154
Thr Val Leu Glu Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly
365                 370                 375                 380
 
tct gcg gac ctg gtt ctg ccg atc ctg acc ccg tct aac ctg acc cgt   1202
Ser Ala Asp Leu Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg
                385                 390                 395
 
tgg aaa gaa gct ctg tct ttt cag ccg ccg tct tct ggt tct ggt aac   1250
Trp Lys Glu Ala Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn
            400                 405                 410
 
tac tct ggt cgt tac atc cgt tac ggt atc cgc gaa cac gct atg ggt   1298
Tyr Ser Gly Arg Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly
        415                 420                 425
 
gcg atc atg aac ggt atc tct gcc ttc ggt gcg aac tac aaa ccg tat   1346
Ala Ile Met Asn Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr
    430                 435                 440
 
ggc ggc acc ttc ctg aac ttc gtt agc tac gcg gcg ggt gca gtt cgt   1394
Gly Gly Thr Phe Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg
445                 450                 455                 460
 
ctg tct gct ctg tct ggt cat ccg gtt att tgg gtt gcg acg cac gac   1442
Leu Ser Ala Leu Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp
                465                 470                 475
 
tct atc ggt gtt ggt gaa gac ggt ccg acc cac cag ccg atc gaa acc   1490
Ser Ile Gly Val Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr
            480                 485                 490
 
ctc gcg cac ttt cgt tct ctg ccg aac atc cag gtg tgg cgt cca gct   1538
Leu Ala His Phe Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala
        495                 500                 505
 
gat ggc aac gaa gtt agc gcg gcg tac aaa aac tct ctc gaa tct aaa   1586
Asp Gly Asn Glu Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys
    510                 515                 520
 
cac acc ccg tct atc atc gcg ctc agc ccg gac aaa acc tgc cac aat   1634
His Thr Pro Ser Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn
525                 530                 535                 540
 
tgg aaa gtt gct ctg atc gaa tct gcg tct aaa ggt ggc tac gtt ctc   1682
Trp Lys Val Ala Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu
                545                 550                 555
 
caa gat gta gcg aac ccg gac atc atc ctg gta gcg acc ggt tct gaa   1730
Gln Asp Val Ala Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu
            560                 565                 570
 
gtt agc ctg tct gtt gag gcg gcg aaa acc ctg gct gcg aaa aac atc   1778
Val Ser Leu Ser Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile
        575                 580                 585
 
aag gcg cgt gtt gtt agc ctg ccg gac ttc ttc acc ttc gac aaa cag   1826
Lys Ala Arg Val Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln
    590                 595                 600
 
ccg ctc gaa tac cgt ctt agc gtt ctg cct gat aac gtt cct atc atg   1874
Pro Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met
605                 610                 615                 620
 
tct gtt gaa gtt ctg gct acc acc tgc tgg ggt aaa tac gcg cac cag   1922
Ser Val Glu Val Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln
                625                 630                 635
 
tct ttc ggt att gat cgt ttc ggt gcc cca gtt cgt cac cag aaa tct   1970
Ser Phe Gly Ile Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser
            640                 645                 650
 
tct tct tct tct gtt agc ccg cag aaa gtt ctg ttg aaa gaa ctg aaa   2018
Ser Ser Ser Ser Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys
        655                 660                 665
 
cgt ccg ctg cac tct atc cgt gtt acc tct actagtcgat gcct           2062
Arg Pro Leu His Ser Ile Arg Val Thr Ser
    670                 675
 

<210> 14
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 14
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 15
<211> 2034
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(2034)

<400> 15
atg act caa ttt act gac att gat aaa ttg gct gtt tct act att aga   48
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                   10                  15
 
att ttg gca gtt gat acg gtt tct aaa gct aac tcc gga cat cca gga   96
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
             20                  25                  30
 
gcc cca tta ggt aga tca cca gca gct cat gtt ttg gga gaa tct aac   144
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
         35                  40                  45
 
gct cac gaa cca aat caa cca aaa act gga tct act gaa att gat ttg   192
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
     50                  55                  60
 
tct tgt ttg act gtt act aga tca ttg tgt tgt att tat ttg cat ttg   240
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
 65                  70                  75                  80
 
act gga tat gat ttg tcg att gaa gat tta aaa caa ttt aga caa ttg   288
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                 85                  90                  95
 
gga tct aga act cca gga cat cca gaa ttt gag ttg cca ggt gtt gaa   336
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110
 
gtt act aca gga cca ttg gga caa gga att tct aat gca gtt gga atg   384
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125
 
gct atg gct caa gca aat ttg gat atg cct ttg act act tct aga gct   432
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140
 
ttt act tta tct gat aat tat act tat gtt ttc ttg gga gat gga tgt   480
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160
 
ttg caa gaa gga att tct agc gag gct tct tct tta gct gga cat tta   528
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175
 
aaa tta gga aat ttg att gct att tat gat gat aat aaa att act att   576
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190
 
gat gga gct act tct att tct ttt gat gag gat gtt gct aaa aga tat   624
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205
 
gag gct tat gga tgg gaa gtt ttg tat gtt gaa aat gga aat gag gat   672
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220
 
ttg gct gga att gct aaa gct att aga caa aga aaa tta tct aaa gat   720
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240
 
aaa cct act ttt gat cag aat gac cat aat cat tgg ctt aga ttt ttg   768
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255
 
aga tct gga tca cat tct gtt cat gga gca cca ctg aag gct gat gat   816
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270
 
gtt aaa caa tta aaa tct aaa ttc gga ttt aat cca gat aaa tct ttt   864
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285
 
gtt gtt cca caa gaa gtt tat gat cat tat cag aaa act att tta aaa   912
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300
 
cct gga gtt gaa gct aat aat aag tgg aat aaa ttg ttt tca gaa tat   960
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320
 
cag aaa aag ttc cca gaa tta gga gct gaa ttg gca aga aga ttg tct   1008
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335
 
ggt caa ctc cct gct aat tgg gaa tct aaa ttg ccc act tat act gct   1056
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350
 
aaa gat tct gct gtt gct act aga aaa ttg tcc gaa act gtt tta gaa   1104
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365
 
gat gtt tat aat cag ttg ccc gaa ctc att gga gga tct gct gat tta   1152
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380
 
gtt ttg cca att ttg act cct tct aat ttg act aga tgg aaa gaa gca   1200
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400
 
ttg tct ttt caa cca cca tct tct gga tct gga aat tat tct ggt aga   1248
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415
 
tat att aga tat gga att aga gaa cat gct atg gga gct att atg aat   1296
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430
 
gga att tct gct ttt ggt gct aat tat aag cct tat gga ggt act ttt   1344
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445
 
ctt aat ttt gtt tct tat gct gct gga gct gtt aga ttg tct gct ctc   1392
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460
 
tct gga cat cct gtt att tgg gtt gct act cat gat tct att gga gtt   1440
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480
 
gga gaa gat gga cct act cat caa cca att gaa act tta gct cat ttt   1488
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495
 
aga tct tta cca aat ata caa gtg tgg aga cct gct gat gga aat gaa   1536
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510
 
gtt tct gct gct tat aaa aat tct tta gaa tct aaa cat act cca tct   1584
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525
 
att att gct ttg tct cca gat aaa acg tgt cat aat tgg aaa gtt gct   1632
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540
 
tta att gaa tct gct tct aaa gga gga tat gtt ttg caa gat gta gct   1680
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560
 
aat cca gat ata att ttg gtt gct act ggt tct gaa gtt tct tta tct   1728
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575
 
gtt gag gct gca aaa act tta gct gct aaa aac att aaa gct aga gta   1776
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590
 
gtt tca ttg cca gac ttc ttt act ttt gat aaa caa cca tta gaa tat   1824
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605
 
aga ttg tct gtt ttg ccc gat aat gtt cca att atg tct gtt gaa gtt   1872
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620
 
ttg gct act act tgt tgg gga aaa tat gct cat caa tct ttc gga att   1920
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640
 
gat aga ttc gga gca cca gtt aga cat caa aaa tct tct tct tct tct   1968
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655
 
gtt tct cca caa aaa gtg ttg tta aaa gaa tta aaa aga cca ttg cat   2016
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670
 
tct att aga gtt act tct                                           2034
Ser Ile Arg Val Thr Ser
        675
 

<210> 16
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 16
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 17
<211> 2056
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(2045)

<400> 17
tactcaagct t atg act caa ttt act gac att gat aaa ttg gct gtt tct  50
             Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser
              1               5                   10
 
act att aga att ttg gca gtt gat acg gtt tct aaa gct aac tcc gga   98
Thr Ile Arg Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly
     15                  20                  25
 
cat cca gga gcc cca tta ggt aga tca cca gca gct cat gtt ttg gga   146
His Pro Gly Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly
 30                  35                  40                  45
 
gaa tct aac gct cac gaa cca aat caa cca aaa act gga tct act gaa   194
Glu Ser Asn Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu
                 50                  55                  60
 
att gat ttg tct tgt ttg act gtt act aga tca ttg tgt tgt att tat   242
Ile Asp Leu Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr
             65                  70                  75
 
ttg cat ttg act gga tat gat ttg tcg att gaa gat tta aaa caa ttt   290
Leu His Leu Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe
         80                  85                  90
 
aga caa ttg gga tct aga act cca gga cat cca gaa ttt gag ttg cca   338
Arg Gln Leu Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro
     95                 100                 105
 
ggt gtt gaa gtt act aca gga cca ttg gga caa gga att tct aat gca   386
Gly Val Glu Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala
110                 115                 120                 125
 
gtt gga atg gct atg gct caa gca aat ttg gat atg cct ttg act act   434
Val Gly Met Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr
                130                 135                 140
 
tct aga gct ttt act tta tct gat aat tat act tat gtt ttc ttg gga   482
Ser Arg Ala Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly
            145                 150                 155
 
gat gga tgt ttg caa gaa gga att tct agc gag gct tct tct tta gct   530
Asp Gly Cys Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala
        160                 165                 170
 
gga cat tta aaa tta gga aat ttg att gct att tat gat gat aat aaa   578
Gly His Leu Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys
    175                 180                 185
 
att act att gat gga gct act tct att tct ttt gat gag gat gtt gct   626
Ile Thr Ile Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala
190                 195                 200                 205
 
aaa aga tat gag gct tat gga tgg gaa gtt ttg tat gtt gaa aat gga   674
Lys Arg Tyr Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly
                210                 215                 220
 
aat gag gat ttg gct gga att gct aaa gct att aga caa aga aaa tta   722
Asn Glu Asp Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu
            225                 230                 235
 
tct aaa gat aaa cct act ttt gat cag aat gac cat aat cat tgg ctt   770
Ser Lys Asp Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu
        240                 245                 250
 
aga ttt ttg aga tct gga tca cat tct gtt cat gga gca cca ctg aag   818
Arg Phe Leu Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys
    255                 260                 265
 
gct gat gat gtt aaa caa tta aaa tct aaa ttc gga ttt aat cca gat   866
Ala Asp Asp Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp
270                 275                 280                 285
 
aaa tct ttt gtt gtt cca caa gaa gtt tat gat cat tat cag aaa act   914
Lys Ser Phe Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr
                290                 295                 300
 
att tta aaa cct gga gtt gaa gct aat aat aag tgg aat aaa ttg ttt   962
Ile Leu Lys Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe
            305                 310                 315
 
tca gaa tat cag aaa aag ttc cca gaa tta gga gct gaa ttg gca aga   1010
Ser Glu Tyr Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg
        320                 325                 330
 
aga ttg tct ggt caa ctc cct gct aat tgg gaa tct aaa ttg ccc act   1058
Arg Leu Ser Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr
    335                 340                 345
 
tat act gct aaa gat tct gct gtt gct act aga aaa ttg tcc gaa act   1106
Tyr Thr Ala Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr
350                 355                 360                 365
 
gtt tta gaa gat gtt tat aat cag ttg ccc gaa ctc att gga gga tct   1154
Val Leu Glu Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser
                370                 375                 380
 
gct gat tta gtt ttg cca att ttg act cct tct aat ttg act aga tgg   1202
Ala Asp Leu Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp
            385                 390                 395
 
aaa gaa gca ttg tct ttt caa cca cca tct tct gga tct gga aat tat   1250
Lys Glu Ala Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr
        400                 405                 410
 
tct ggt aga tat att aga tat gga att aga gaa cat gct atg gga gct   1298
Ser Gly Arg Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala
    415                 420                 425
 
att atg aat gga att tct gct ttt ggt gct aat tat aag cct tat gga   1346
Ile Met Asn Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly
430                 435                 440                 445
 
ggt act ttt ctt aat ttt gtt tct tat gct gct gga gct gtt aga ttg   1394
Gly Thr Phe Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu
                450                 455                 460
 
tct gct ctc tct gga cat cct gtt att tgg gtt gct act cat gat tct   1442
Ser Ala Leu Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser
            465                 470                 475
 
att gga gtt gga gaa gat gga cct act cat caa cca att gaa act tta   1490
Ile Gly Val Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu
        480                 485                 490
 
gct cat ttt aga tct tta cca aat ata caa gtg tgg aga cct gct gat   1538
Ala His Phe Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp
    495                 500                 505
 
gga aat gaa gtt tct gct gct tat aaa aat tct tta gaa tct aaa cat   1586
Gly Asn Glu Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His
510                 515                 520                 525
 
act cca tct att att gct ttg tct cca gat aaa acg tgt cat aat tgg   1634
Thr Pro Ser Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp
                530                 535                 540
 
aaa gtt gct tta att gaa tct gct tct aaa gga gga tat gtt ttg caa   1682
Lys Val Ala Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln
            545                 550                 555
 
gat gta gct aat cca gat ata att ttg gtt gct act ggt tct gaa gtt   1730
Asp Val Ala Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val
        560                 565                 570
 
tct tta tct gtt gag gct gca aaa act tta gct gct aaa aac att aaa   1778
Ser Leu Ser Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys
    575                 580                 585
 
gct aga gta gtt tca ttg cca gac ttc ttt act ttt gat aaa caa cca   1826
Ala Arg Val Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro
590                 595                 600                 605
 
tta gaa tat aga ttg tct gtt ttg ccc gat aat gtt cca att atg tct   1874
Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser
                610                 615                 620
 
gtt gaa gtt ttg gct act act tgt tgg gga aaa tat gct cat caa tct   1922
Val Glu Val Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser
            625                 630                 635
 
ttc gga att gat aga ttc gga gca cca gtt aga cat caa aaa tct tct   1970
Phe Gly Ile Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser
        640                 645                 650
 
tct tct tct gtt tct cca caa aaa gtg ttg tta aaa gaa tta aaa aga   2018
Ser Ser Ser Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg
    655                 660                 665
 
cca ttg cat tct att aga gtt act tct gaattccgat g                  2056
Pro Leu His Ser Ile Arg Val Thr Ser
670                 675
 

<210> 18
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 18
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 19
<211> 2062
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(2048)

<400> 19
gaatactcca tatg atg act caa ttt act gac att gat aaa ttg gct gtt   50
                Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val
                 1               5                   10
 
tct act att aga att ttg gca gtt gat acg gtt tct aaa gct aac tcc   98
Ser Thr Ile Arg Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser
         15                  20                  25
 
gga cat cca gga gcc cca tta ggt aga tca cca gca gct cat gtt ttg   146
Gly His Pro Gly Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu
     30                  35                  40
 
gga gaa tct aac gct cac gaa cca aat caa cca aaa act gga tct act   194
Gly Glu Ser Asn Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr
 45                  50                  55                  60
 
gaa att gat ttg tct tgt ttg act gtt act aga tca ttg tgt tgt att   242
Glu Ile Asp Leu Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile
                 65                  70                  75
 
tat ttg cat ttg act gga tat gat ttg tcg att gaa gat tta aaa caa   290
Tyr Leu His Leu Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln
             80                  85                  90
 
ttt aga caa ttg gga tct aga act cca gga cat cca gaa ttt gag ttg   338
Phe Arg Gln Leu Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu
         95                 100                 105
 
cca ggt gtt gaa gtt act aca gga cca ttg gga caa gga att tct aat   386
Pro Gly Val Glu Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn
    110                 115                 120
 
gca gtt gga atg gct atg gct caa gca aat ttg gat atg cct ttg act   434
Ala Val Gly Met Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr
125                 130                 135                 140
 
act tct aga gct ttt act tta tct gat aat tat act tat gtt ttc ttg   482
Thr Ser Arg Ala Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu
                145                 150                 155
 
gga gat gga tgt ttg caa gaa gga att tct agc gag gct tct tct tta   530
Gly Asp Gly Cys Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu
            160                 165                 170
 
gct gga cat tta aaa tta gga aat ttg att gct att tat gat gat aat   578
Ala Gly His Leu Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn
        175                 180                 185
 
aaa att act att gat gga gct act tct att tct ttt gat gag gat gtt   626
Lys Ile Thr Ile Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val
    190                 195                 200
 
gct aaa aga tat gag gct tat gga tgg gaa gtt ttg tat gtt gaa aat   674
Ala Lys Arg Tyr Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn
205                 210                 215                 220
 
gga aat gag gat ttg gct gga att gct aaa gct att aga caa aga aaa   722
Gly Asn Glu Asp Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys
                225                 230                 235
 
tta tct aaa gat aaa cct act ttt gat cag aat gac cat aat cat tgg   770
Leu Ser Lys Asp Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp
            240                 245                 250
 
ctt aga ttt ttg aga tct gga tca cat tct gtt cat gga gca cca ctg   818
Leu Arg Phe Leu Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu
        255                 260                 265
 
aag gct gat gat gtt aaa caa tta aaa tct aaa ttc gga ttt aat cca   866
Lys Ala Asp Asp Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro
    270                 275                 280
 
gat aaa tct ttt gtt gtt cca caa gaa gtt tat gat cat tat cag aaa   914
Asp Lys Ser Phe Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys
285                 290                 295                 300
 
act att tta aaa cct gga gtt gaa gct aat aat aag tgg aat aaa ttg   962
Thr Ile Leu Lys Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu
                305                 310                 315
 
ttt tca gaa tat cag aaa aag ttc cca gaa tta gga gct gaa ttg gca   1010
Phe Ser Glu Tyr Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala
            320                 325                 330
 
aga aga ttg tct ggt caa ctc cct gct aat tgg gaa tct aaa ttg ccc   1058
Arg Arg Leu Ser Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro
        335                 340                 345
 
act tat act gct aaa gat tct gct gtt gct act aga aaa ttg tcc gaa   1106
Thr Tyr Thr Ala Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu
    350                 355                 360
 
act gtt tta gaa gat gtt tat aat cag ttg ccc gaa ctc att gga gga   1154
Thr Val Leu Glu Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly
365                 370                 375                 380
 
tct gct gat tta gtt ttg cca att ttg act cct tct aat ttg act aga   1202
Ser Ala Asp Leu Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg
                385                 390                 395
 
tgg aaa gaa gca ttg tct ttt caa cca cca tct tct gga tct gga aat   1250
Trp Lys Glu Ala Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn
            400                 405                 410
 
tat tct ggt aga tat att aga tat gga att aga gaa cat gct atg gga   1298
Tyr Ser Gly Arg Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly
        415                 420                 425
 
gct att atg aat gga att tct gct ttt ggt gct aat tat aag cct tat   1346
Ala Ile Met Asn Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr
    430                 435                 440
 
gga ggt act ttt ctt aat ttt gtt tct tat gct gct gga gct gtt aga   1394
Gly Gly Thr Phe Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg
445                 450                 455                 460
 
ttg tct gct ctc tct gga cat cct gtt att tgg gtt gct act cat gat   1442
Leu Ser Ala Leu Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp
                465                 470                 475
 
tct att gga gtt gga gaa gat gga cct act cat caa cca att gaa act   1490
Ser Ile Gly Val Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr
            480                 485                 490
 
tta gct cat ttt aga tct tta cca aat ata caa gtg tgg aga cct gct   1538
Leu Ala His Phe Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala
        495                 500                 505
 
gat gga aat gaa gtt tct gct gct tat aaa aat tct tta gaa tct aaa   1586
Asp Gly Asn Glu Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys
    510                 515                 520
 
cat act cca tct att att gct ttg tct cca gat aaa acg tgt cat aat   1634
His Thr Pro Ser Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn
525                 530                 535                 540
 
tgg aaa gtt gct tta att gaa tct gct tct aaa gga gga tat gtt ttg   1682
Trp Lys Val Ala Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu
                545                 550                 555
 
caa gat gta gct aat cca gat ata att ttg gtt gct act ggt tct gaa   1730
Gln Asp Val Ala Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu
            560                 565                 570
 
gtt tct tta tct gtt gag gct gca aaa act tta gct gct aaa aac att   1778
Val Ser Leu Ser Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile
        575                 580                 585
 
aaa gct aga gta gtt tca ttg cca gac ttc ttt act ttt gat aaa caa   1826
Lys Ala Arg Val Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln
    590                 595                 600
 
cca tta gaa tat aga ttg tct gtt ttg ccc gat aat gtt cca att atg   1874
Pro Leu Glu Tyr Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met
605                 610                 615                 620
 
tct gtt gaa gtt ttg gct act act tgt tgg gga aaa tat gct cat caa   1922
Ser Val Glu Val Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln
                625                 630                 635
 
tct ttc gga att gat aga ttc gga gca cca gtt aga cat caa aaa tct   1970
Ser Phe Gly Ile Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser
            640                 645                 650
 
tct tct tct tct gtt tct cca caa aaa gtg ttg tta aaa gaa tta aaa   2018
Ser Ser Ser Ser Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys
        655                 660                 665
 
aga cca ttg cat tct att aga gtt act tct actagtcgat gcct           2062
Arg Pro Leu His Ser Ile Arg Val Thr Ser
    670                 675
 

<210> 20
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 20
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 21
<211> 2034
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K.  lactis

<220> 
<221> CDS            
<222> (1)...(2034)

<400> 21
atg act caa ttc act gac att gat aag ttg gct gtt tct act att aga   48
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                   10                  15
 
att ttg gca gta gat act gtt tct aaa gct aat tct gga cat cca ggt   96
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
             20                  25                  30
 
gct cca ttg ggt aga tct cct gct gct cat gtt ttg ggt gaa tct aat   144
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
         35                  40                  45
 
gct cac gaa cca aat caa cca aaa act ggt agt act gaa att gat ttg   192
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
     50                  55                  60
 
tct tgt ttg act gtt act aga tca ttg tgt tgt att tac ttg cat ttg   240
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
 65                  70                  75                  80
 
act ggt tat gat ttg tcg att gaa gat tta aaa caa ttc aga caa ttg   288
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                 85                  90                  95
 
ggt tct agg act cca ggt cat cca gaa ttt gaa ttg cca ggt gtt gaa   336
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110
 
gtt act act ggt cca ctt ggg caa gga att tct aat gct gtt ggt atg   384
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125
 
gct atg gct caa gct aat ttg gat atg cca ttg act act tct agg gct   432
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140
 
ttc act tta tct gat aat tat act tat gtt ttc ttg ggt gat ggt tgt   480
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160
 
ttg caa gaa gga att tca tct gaa gct agt tca ttg gct ggt cat tta   528
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175
 
aaa ttg ggt aat ctg atc gct att tat gat gat aat aaa att act att   576
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190
 
gat ggt gct act tct att tct ttc gat gaa gat gta gca aaa aga tat   624
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205
 
gaa gcc tat ggt tgg gaa gtt ttg tat gtt gaa aat ggt aat gaa gat   672
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220
 
ttg gcg gga att gct aaa gct att aga caa aga aaa ttg tct aaa gat   720
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240
 
aag cca aca ttc gat caa aat gat cat aat cat tgg ttg aga ttc ttg   768
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255
 
aga tct ggt tct cat tct gtt cat ggg gct cct ctt aaa gct gat gat   816
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270
 
gtt aaa caa tta aaa tct aaa ttc ggt ttc aat cca gac aaa tcg ttc   864
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285
 
gtt gtt cca caa gaa gtt tat gat cat tat cag aaa act att tta aaa   912
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300
 
cca ggc gtg gag gct aat aat aag tgg aat aaa ttg ttc tct gaa tat   960
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320
 
cag aaa aag ttc cct gaa ttg ggt gct gaa ttg gcg aga cgt ttg tct   1008
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335
 
ggg caa tta cct gct aat tgg gaa tct aaa ttg cca acg tac act gct   1056
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350
 
aaa gat tct gct gtg gct act agg aag ttg tct gaa act gtt ctg gaa   1104
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365
 
gat gtt tat aat caa ctc ccg gaa ctg att ggt gga tct gct gat ttg   1152
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380
 
gtg ttg cca att ttg act cca tct aat ttg act aga tgg aaa gaa gca   1200
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400
 
tta tct ttt caa cct ccg tct tct ggt agt ggt aat tat tct ggt aga   1248
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415
 
tat att aga tat gga att aga gaa cat gct atg gga gcg att atg aat   1296
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430
 
gga atc tct gct ttc ggt gct aat tat aaa cct tat ggt ggt aca ttc   1344
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445
 
tta aac ttc gtt agc tat gct gca ggg gca gtt aga ttg tcc gct ttg   1392
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460
 
tcg ggc cac cct gtt att tgg gtt gct aca cat gat tct att ggt gta   1440
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480
 
gga gaa gat ggt cca act cat caa cca att gaa aca ttg gct cac ttc   1488
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495
 
aga tca ttg cca aac atc caa gtt tgg aga cca gct gat gga aat gag   1536
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510
 
gtt tct gcg gcg tat aaa aat tca ttg gaa tct aaa cat act cca agt   1584
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525
 
att att gct ttg agt cct gat aag act tgt cat aat tgg aaa gtt gct   1632
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540
 
ttg att gaa tct gct tct aaa ggt ggt tat gtt ttg caa gac gtc gca   1680
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560
 
aat cca gat ata att ttg gtt gcg aca ggt tct gaa gtt tct tta tct   1728
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575
 
gtt gaa gct gca aaa aca tta gcc gct aaa aat att aaa gct aga gtt   1776
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590
 
gtt tct tta cca gat ttc ttc act ttc gac aaa caa ccg ctc gaa tat   1824
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605
 
aga ttg tcg gtt tta cca gat aat gtt cca att atg tct gtt gag gtt   1872
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620
 
ttg gct act act tgt tgg gga aaa tat gct cat caa tct ttc gga ata   1920
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640
 
gat aga ttc gga gcg ccg gtt aga cat caa aaa tct tct tct tca tct   1968
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655
 
gtt tca cca caa aaa gtt ttg tta aag gaa tta aaa aga cca ttg cat   2016
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670
 
tct att aga gtt act tct                                           2034
Ser Ile Arg Val Thr Ser
        675
 

<210> 22
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 22
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 23
<211> 2034
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(2034)

<400> 23
atg acc cag ttt acc gac att gat aaa ttg gcc gtt tct acc att cgt   48
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                   10                  15
 
att ttg gct gtc gac acc gtt tct aaa gct aat agc ggt cat cct ggt   96
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
             20                  25                  30
 
gcc ccg ttg ggt cgt tct ccg gct gct cat gtt ttg ggt gaa tct aat   144
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
         35                  40                  45
 
gcc cat gaa ccg aat cag ccg aaa acc ggt agc act gaa att gat ttg   192
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
     50                  55                  60
 
tct tgt ttg acc gtt acc cgc tct ttg tgt tgt att tat ttg cat ttg   240
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
 65                  70                  75                  80
 
acc ggt tat gac ttg tct att gaa gat ttg aaa cag ttt cgt cag ttg   288
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                 85                  90                  95
 
ggt tct cgt acc cca ggc cat cca gaa ttt gaa ttg ccc ggc gtt gaa   336
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110
 
gtt acc acg gga cca ttg ggg cag ggc att tct aat gcc gtt ggt atg   384
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125
 
gct atg gct cag gct aat ttg gat atg cct ctg acc acc tct cgt gcc   432
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140
 
ttc acc ttg tct gat aat tat acg tat gtc ttt ttg ggc gat ggt tgt   480
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160
 
ttg cag gaa ggg att tct tct gag gcg tct tct ttg gct gga cat ttg   528
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175
 
aaa ttg ggt aat ttg att gcc att tat gat gat aat aaa att acc att   576
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190
 
gat ggt gcg acc tct att tct ttt gat gaa gat gtt gcc aaa cgt tat   624
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205
 
gaa gcg tat ggt tgg gaa gtt ttg tat gtt gaa aat ggt aat gaa gat   672
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220
 
cta gca gga att gcc aaa gca att cgt cag cgc aaa ttg tct aaa gat   720
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240
 
aaa ccg acc ttt gat cag aat gat cat aat cat tgg ttg aga ttt ttg   768
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255
 
cgt tct ggt tct cat tct gta cat ggt gct ccc ctg aaa gcc gat gat   816
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270
 
gtt aaa cag ttg aaa tct aaa ttt ggt ttt aat ccg gat aaa tct ttt   864
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285
 
gtt gtt ccg cag gag gtt tat gat cat tat cag aaa acc att ttg aaa   912
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300
 
cca ggg gtt gag gct aat aat aaa tgg aat aaa ttg ttt tct gaa tat   960
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320
 
cag aag aag ttt ccg gaa ttg ggt gcc gaa tta gct cgt cgg ttg tct   1008
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335
 
ggc caa ctg cct gct aat tgg gaa tct aaa ttg cct aca tat acc gct   1056
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350
 
aag gat tct gcc gta gct act cgc aaa cta agt gaa acc gtt ttg gaa   1104
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365
 
gat gtt tat aat cag ttg cct gaa ttg att gga ggt tct gct gat ctt   1152
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380
 
gtc ttg cct att ttg acc ccg agt aat ttg acg cgt tgg aaa gaa gct   1200
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400
 
ctt tct ttt cag cca cct agt tct ggt agt ggt aat tat tct ggt cgt   1248
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415
 
tat att cgt tat ggc atc cgt gaa cat gct atg ggc gca att atg aat   1296
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430
 
ggc att agt gct ttc ggt gct aat tat aaa ccg tat ggc ggc acg ttt   1344
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445
 
ttg aat ttt gtt tct tat gct gct gga gct gtt cgt ttg agt gcg ttg   1392
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460
 
agt gga cat ccg gtt atc tgg gtt gcc acg cat gat tct att ggt gtt   1440
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480
 
ggt gaa gat ggt cct acg cat caa ccg att gaa acc ttg gcc cat ttt   1488
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495
 
cgt tct ttg ccg aac att cag gtt tgg cgt cca gct gat ggt aat gag   1536
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510
 
gtt tct gca gct tat aaa aat tct ttg gaa tct aaa cat acc cct agt   1584
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525
 
att att gct ctt tct cct gat aaa acc tgt cat aat tgg aaa gtt gcg   1632
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540
 
ttg ata gaa tct gcc tct aaa ggt ggt tat gtt ttg caa gac gtc gct   1680
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560
 
aac cct gat atc att ttg gtt gct act ggt agc gaa gtt tct ttg tct   1728
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575
 
gtt gaa gca gct aaa aca ctc gct gcg aaa aat att aaa gct cgt gtt   1776
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590
 
gtt tct ctt ccg gat ttc ttt acc ttt gat aaa cag cct ctt gaa tat   1824
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605
 
cgt ttg tca gtt ttg cct gac aat gtt ccg att atg tct gtg gaa gtt   1872
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620
 
cta gcg aca act tgt tgg ggt aaa tat gct cat cag tct ttt ggt ata   1920
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640
 
gat cgt ttc ggc gct cct gtc cga cat cag aaa tct tct tct agc tct   1968
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655
 
gtt tct ccg caa aag gtc ctt cta aaa gaa ttg aaa cgt ccg ttg cat   2016
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670
 
tct att cgt gtt acc tct                                           2034
Ser Ile Arg Val Thr Ser
        675
 

<210> 24
<211> 678
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 24
Met Thr Gln Phe Thr Asp Ile Asp Lys Leu Ala Val Ser Thr Ile Arg
 1               5                  10                  15      
Ile Leu Ala Val Asp Thr Val Ser Lys Ala Asn Ser Gly His Pro Gly
            20                  25                  30          
Ala Pro Leu Gly Arg Ser Pro Ala Ala His Val Leu Gly Glu Ser Asn
        35                  40                  45              
Ala His Glu Pro Asn Gln Pro Lys Thr Gly Ser Thr Glu Ile Asp Leu
    50                  55                  60                  
Ser Cys Leu Thr Val Thr Arg Ser Leu Cys Cys Ile Tyr Leu His Leu
65                  70                  75                  80  
Thr Gly Tyr Asp Leu Ser Ile Glu Asp Leu Lys Gln Phe Arg Gln Leu
                85                  90                  95      
Gly Ser Arg Thr Pro Gly His Pro Glu Phe Glu Leu Pro Gly Val Glu
            100                 105                 110         
Val Thr Thr Gly Pro Leu Gly Gln Gly Ile Ser Asn Ala Val Gly Met
        115                 120                 125             
Ala Met Ala Gln Ala Asn Leu Asp Met Pro Leu Thr Thr Ser Arg Ala
    130                 135                 140                 
Phe Thr Leu Ser Asp Asn Tyr Thr Tyr Val Phe Leu Gly Asp Gly Cys
145                 150                 155                 160 
Leu Gln Glu Gly Ile Ser Ser Glu Ala Ser Ser Leu Ala Gly His Leu
                165                 170                 175     
Lys Leu Gly Asn Leu Ile Ala Ile Tyr Asp Asp Asn Lys Ile Thr Ile
            180                 185                 190         
Asp Gly Ala Thr Ser Ile Ser Phe Asp Glu Asp Val Ala Lys Arg Tyr
        195                 200                 205             
Glu Ala Tyr Gly Trp Glu Val Leu Tyr Val Glu Asn Gly Asn Glu Asp
    210                 215                 220                 
Leu Ala Gly Ile Ala Lys Ala Ile Arg Gln Arg Lys Leu Ser Lys Asp
225                 230                 235                 240 
Lys Pro Thr Phe Asp Gln Asn Asp His Asn His Trp Leu Arg Phe Leu
                245                 250                 255     
Arg Ser Gly Ser His Ser Val His Gly Ala Pro Leu Lys Ala Asp Asp
            260                 265                 270         
Val Lys Gln Leu Lys Ser Lys Phe Gly Phe Asn Pro Asp Lys Ser Phe
        275                 280                 285             
Val Val Pro Gln Glu Val Tyr Asp His Tyr Gln Lys Thr Ile Leu Lys
    290                 295                 300                 
Pro Gly Val Glu Ala Asn Asn Lys Trp Asn Lys Leu Phe Ser Glu Tyr
305                 310                 315                 320 
Gln Lys Lys Phe Pro Glu Leu Gly Ala Glu Leu Ala Arg Arg Leu Ser
                325                 330                 335     
Gly Gln Leu Pro Ala Asn Trp Glu Ser Lys Leu Pro Thr Tyr Thr Ala
            340                 345                 350         
Lys Asp Ser Ala Val Ala Thr Arg Lys Leu Ser Glu Thr Val Leu Glu
        355                 360                 365             
Asp Val Tyr Asn Gln Leu Pro Glu Leu Ile Gly Gly Ser Ala Asp Leu
    370                 375                 380                 
Val Leu Pro Ile Leu Thr Pro Ser Asn Leu Thr Arg Trp Lys Glu Ala
385                 390                 395                 400 
Leu Ser Phe Gln Pro Pro Ser Ser Gly Ser Gly Asn Tyr Ser Gly Arg
                405                 410                 415     
Tyr Ile Arg Tyr Gly Ile Arg Glu His Ala Met Gly Ala Ile Met Asn
            420                 425                 430         
Gly Ile Ser Ala Phe Gly Ala Asn Tyr Lys Pro Tyr Gly Gly Thr Phe
        435                 440                 445             
Leu Asn Phe Val Ser Tyr Ala Ala Gly Ala Val Arg Leu Ser Ala Leu
    450                 455                 460                 
Ser Gly His Pro Val Ile Trp Val Ala Thr His Asp Ser Ile Gly Val
465                 470                 475                 480 
Gly Glu Asp Gly Pro Thr His Gln Pro Ile Glu Thr Leu Ala His Phe
                485                 490                 495     
Arg Ser Leu Pro Asn Ile Gln Val Trp Arg Pro Ala Asp Gly Asn Glu
            500                 505                 510         
Val Ser Ala Ala Tyr Lys Asn Ser Leu Glu Ser Lys His Thr Pro Ser
        515                 520                 525             
Ile Ile Ala Leu Ser Pro Asp Lys Thr Cys His Asn Trp Lys Val Ala
    530                 535                 540                 
Leu Ile Glu Ser Ala Ser Lys Gly Gly Tyr Val Leu Gln Asp Val Ala
545                 550                 555                 560 
Asn Pro Asp Ile Ile Leu Val Ala Thr Gly Ser Glu Val Ser Leu Ser
                565                 570                 575     
Val Glu Ala Ala Lys Thr Leu Ala Ala Lys Asn Ile Lys Ala Arg Val
            580                 585                 590         
Val Ser Leu Pro Asp Phe Phe Thr Phe Asp Lys Gln Pro Leu Glu Tyr
        595                 600                 605             
Arg Leu Ser Val Leu Pro Asp Asn Val Pro Ile Met Ser Val Glu Val
    610                 615                 620                 
Leu Ala Thr Thr Cys Trp Gly Lys Tyr Ala His Gln Ser Phe Gly Ile
625                 630                 635                 640 
Asp Arg Phe Gly Ala Pro Val Arg His Gln Lys Ser Ser Ser Ser Ser
                645                 650                 655     
Val Ser Pro Gln Lys Val Leu Leu Lys Glu Leu Lys Arg Pro Leu His
            660                 665                 670         
Ser Ile Arg Val Thr Ser
        675             


<210> 25
<211> 717
<212> DNA
<213> S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(717)

<400> 25
atg gtc aaa cca att ata gct ccc agt atc ctt gct tct gac ttc gcc   48
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                   10                  15
 
aac ttg ggt tgc gaa tgt cat aag gtc atc aac gcc ggc gca gat tgg   96
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
             20                  25                  30
 
tta cat atc gat gtc atg gac ggc cat ttt gtt cca aac att act ctg   144
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
         35                  40                  45
 
ggc caa cca att gtt acc tcc cta cgt cgt tct gtg cca cgc cct ggc   192
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
     50                  55                  60
 
gat gct agc aac aca gaa aag aag ccc act gcg ttc ttc gat tgt cac   240
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
 65                  70                  75                  80
 
atg atg gtt gaa aat cct gaa aaa tgg gtc gac gat ttt gct aaa tgt   288
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                 85                  90                  95
 
ggt gct gac caa ttt acg ttc cac tac gag gcc aca caa gac cct ttg   336
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110
 
cat tta gtt aag ttg att aag tct aag ggc atc aaa gct gca tgc gcc   384
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125
 
atc aaa cct ggt act tct gtt gac gtt tta ttt gaa cta gct cct cat   432
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140
 
ttg gat atg gct ctt gtt atg act gtg gaa cct ggg ttt gga ggc caa   480
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160
 
aaa ttc atg gaa gac atg atg cca aaa gtg gaa act ttg aga gcc aag   528
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175
 
ttc ccc cat ttg aat atc caa gtc gat ggt ggt ttg ggc aag gag acc   576
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190
 
atc ccg aaa gcc gcc aaa gcc ggt gcc aac gtt att gtc gct ggt acc   624
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205
 
agt gtt ttc act gca gct gac ccg cac gat gtt atc tcc ttc atg aaa   672
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220
 
gaa gaa gtc tcg aag gaa ttg cgt tct aga gat ttg cta gat tag       717
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp  *
225                 230                 235
 


<210> 26
<211> 238
<212> PRT
<213> S. cerevisiae

<400> 26
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 27
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(714)

<400> 27
atg gtt aaa cca att att gct cca tct att ttg gct tct gac ttt gct   48
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                   10                  15
 
aat ttg ggt tgt gaa tgt cat aaa gta att aat gct ggt gct gat tgg   96
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
             20                  25                  30
 
ttg cat att gat gtt atg gat ggt cat ttc gtt cca aat ata act cta   144
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
         35                  40                  45
 
ggt caa cca att gtt act tct ttg aga cgt tct gtt cct aga cca ggt   192
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
     50                  55                  60
 
gat gca tct aat act gaa aag aag cca act gcg ttc ttt gat tgt cac   240
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
 65                  70                  75                  80
 
atg atg gtt gaa aat cct gaa aaa tgg gtt gat gat ttt gct aaa tgt   288
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                 85                  90                  95
 
ggt gct gat caa ttt act ttt cat tat gaa gca act caa gat cca ttg   336
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110
 
cat ttg gtt aaa ttg att aaa tct aaa gga att aaa gct gct tgt gct   384
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125
 
att aag cca ggt act tct gtt gat gtt ttg ttt gaa ttg gct cca cat   432
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140
 
ttg gat atg gct ttg gtt atg act gtt gaa cca ggt ttt gga ggt caa   480
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160
 
aaa ttt atg gaa gat atg atg cca aag gtt gaa act cta aga gct aaa   528
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175
 
ttt cca cat tta aac att cag gtt gat ggt ggt ttg ggt aaa gaa act   576
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190
 
att cca aag gct gct aaa gct ggt gct aat gta att gtt gct ggt act   624
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205
 
tca gtt ttt act gct gct gat cca cat gat gta att tct ttt atg aaa   672
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220
 
gaa gaa gtt tca aaa gaa ttg aga tct aga gat ttg ttg gat           714
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235
 


<210> 28
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 28
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 29
<211> 736
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(725)

<400> 29
tactcaagct t atg gtt aaa cca att att gct cca tct att ttg gct tct  50
             Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser
              1               5                   10
 
gac ttt gct aat ttg ggt tgt gaa tgt cat aaa gta att aat gct ggt   98
Asp Phe Ala Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly
     15                  20                  25
 
gct gat tgg ttg cat att gat gtt atg gat ggt cat ttc gtt cca aat   146
Ala Asp Trp Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn
 30                  35                  40                  45
 
ata act cta ggt caa cca att gtt act tct ttg aga cgt tct gtt cct   194
Ile Thr Leu Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro
                 50                  55                  60
 
aga cca ggt gat gca tct aat act gaa aag aag cca act gcg ttc ttt   242
Arg Pro Gly Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe
             65                  70                  75
 
gat tgt cac atg atg gtt gaa aat cct gaa aaa tgg gtt gat gat ttt   290
Asp Cys His Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe
         80                  85                  90
 
gct aaa tgt ggt gct gat caa ttt act ttt cat tat gaa gca act caa   338
Ala Lys Cys Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln
     95                 100                 105
 
gat cca ttg cat ttg gtt aaa ttg att aaa tct aaa gga att aaa gct   386
Asp Pro Leu His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala
110                 115                 120                 125
 
gct tgt gct att aag cca ggt act tct gtt gat gtt ttg ttt gaa ttg   434
Ala Cys Ala Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu
                130                 135                 140
 
gct cca cat ttg gat atg gct ttg gtt atg act gtt gaa cca ggt ttt   482
Ala Pro His Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe
            145                 150                 155
 
gga ggt caa aaa ttt atg gaa gat atg atg cca aag gtt gaa act cta   530
Gly Gly Gln Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu
        160                 165                 170
 
aga gct aaa ttt cca cat tta aac att cag gtt gat ggt ggt ttg ggt   578
Arg Ala Lys Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly
    175                 180                 185
 
aaa gaa act att cca aag gct gct aaa gct ggt gct aat gta att gtt   626
Lys Glu Thr Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val
190                 195                 200                 205
 
gct ggt act tca gtt ttt act gct gct gat cca cat gat gta att tct   674
Ala Gly Thr Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser
                210                 215                 220
 
ttt atg aaa gaa gaa gtt tca aaa gaa ttg aga tct aga gat ttg ttg   722
Phe Met Lys Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu
            225                 230                 235
 
gat gaattccgat g                                                  736
Asp

 

<210> 30
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 30
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 31
<211> 742
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(728)

<400> 31
gaatactcca tatg atg gtt aaa cca att att gct cca tct att ttg gct   50
                Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala
                 1               5                   10
 
tct gac ttt gct aat ttg ggt tgt gaa tgt cat aaa gta att aat gct   98
Ser Asp Phe Ala Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala
         15                  20                  25
 
ggt gct gat tgg ttg cat att gat gtt atg gat ggt cat ttc gtt cca   146
Gly Ala Asp Trp Leu His Ile Asp Val Met Asp Gly His Phe Val Pro
     30                  35                  40
 
aat ata act cta ggt caa cca att gtt act tct ttg aga cgt tct gtt   194
Asn Ile Thr Leu Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val
 45                  50                  55                  60
 
cct aga cca ggt gat gca tct aat act gaa aag aag cca act gcg ttc   242
Pro Arg Pro Gly Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe
                 65                  70                  75
 
ttt gat tgt cac atg atg gtt gaa aat cct gaa aaa tgg gtt gat gat   290
Phe Asp Cys His Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp
             80                  85                  90
 
ttt gct aaa tgt ggt gct gat caa ttt act ttt cat tat gaa gca act   338
Phe Ala Lys Cys Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr
         95                 100                 105
 
caa gat cca ttg cat ttg gtt aaa ttg att aaa tct aaa gga att aaa   386
Gln Asp Pro Leu His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys
    110                 115                 120
 
gct gct tgt gct att aag cca ggt act tct gtt gat gtt ttg ttt gaa   434
Ala Ala Cys Ala Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu
125                 130                 135                 140
 
ttg gct cca cat ttg gat atg gct ttg gtt atg act gtt gaa cca ggt   482
Leu Ala Pro His Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly
                145                 150                 155
 
ttt gga ggt caa aaa ttt atg gaa gat atg atg cca aag gtt gaa act   530
Phe Gly Gly Gln Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr
            160                 165                 170
 
cta aga gct aaa ttt cca cat tta aac att cag gtt gat ggt ggt ttg   578
Leu Arg Ala Lys Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu
        175                 180                 185
 
ggt aaa gaa act att cca aag gct gct aaa gct ggt gct aat gta att   626
Gly Lys Glu Thr Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile
    190                 195                 200
 
gtt gct ggt act tca gtt ttt act gct gct gat cca cat gat gta att   674
Val Ala Gly Thr Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile
205                 210                 215                 220
 
tct ttt atg aaa gaa gaa gtt tca aaa gaa ttg aga tct aga gat ttg   722
Ser Phe Met Lys Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu
                225                 230                 235
 
ttg gat actagtcgat gcct                                           742
Leu Asp

 

<210> 32
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 32
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 33
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(714)

<400> 33
atg gtt aaa cca att att gct cca tct att ttg gct tct gac ttt gct   48
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                   10                  15
 
aat ttg ggt tgt gaa tgt cat aaa gta att aat gct ggt gct gat tgg   96
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
             20                  25                  30
 
ttg cat att gat gtt atg gat ggt cat ttc gtt cca aat ata act cta   144
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
         35                  40                  45
 
ggt caa cca att gtt act tct ttg aga cgt tct gtt cct aga cca ggt   192
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
     50                  55                  60
 
gat gca tct aat act gaa aag aag cca act gcg ttc ttt gat tgt cac   240
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
 65                  70                  75                  80
 
atg atg gtt gaa aat cct gaa aaa tgg gtt gat gat ttt gct aaa tgt   288
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                 85                  90                  95
 
ggt gct gat caa ttt act ttt cat tat gaa gca act caa gat cca ttg   336
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110
 
cat ttg gtt aaa ttg att aaa tct aaa gga att aaa gct gct tgt gct   384
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125
 
att aag cca ggt act tct gtt gat gtt ttg ttt gaa ttg gct cca cat   432
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140
 
ttg gat atg gct ttg gtt atg act gtt gaa cca ggt ttt gga ggt caa   480
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160
 
aaa ttt atg gaa gat atg atg cca aag gtt gaa act cta aga gct aaa   528
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175
 
ttt cca cat tta aac att cag gtt gat ggt ggt ttg ggt aaa gaa act   576
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190
 
att cca aag gct gct aaa gct ggt gct aat gta att gtt gct ggt act   624
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205
 
tca gtt ttt act gct gct gat cca cat gat gta att tct ttt atg aaa   672
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220
 
gaa gaa gtt tca aaa gaa ttg aga tct aga gat ttg ttg gat           714
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235
 


<210> 34
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 34
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 35
<211> 736
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(725)

<400> 35
tactcaagct t atg gtt aaa cca att att gct cca tct att ttg gct tct  50
             Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser
              1               5                   10
 
gac ttt gct aat ttg ggt tgt gaa tgt cat aaa gta att aat gct ggt   98
Asp Phe Ala Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly
     15                  20                  25
 
gct gat tgg ttg cat att gat gtt atg gat ggt cat ttc gtt cca aat   146
Ala Asp Trp Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn
 30                  35                  40                  45
 
ata act cta ggt caa cca att gtt act tct ttg aga cgt tct gtt cct   194
Ile Thr Leu Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro
                 50                  55                  60
 
aga cca ggt gat gca tct aat act gaa aag aag cca act gcg ttc ttt   242
Arg Pro Gly Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe
             65                  70                  75
 
gat tgt cac atg atg gtt gaa aat cct gaa aaa tgg gtt gat gat ttt   290
Asp Cys His Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe
         80                  85                  90
 
gct aaa tgt ggt gct gat caa ttt act ttt cat tat gaa gca act caa   338
Ala Lys Cys Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln
     95                 100                 105
 
gat cca ttg cat ttg gtt aaa ttg att aaa tct aaa gga att aaa gct   386
Asp Pro Leu His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala
110                 115                 120                 125
 
gct tgt gct att aag cca ggt act tct gtt gat gtt ttg ttt gaa ttg   434
Ala Cys Ala Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu
                130                 135                 140
 
gct cca cat ttg gat atg gct ttg gtt atg act gtt gaa cca ggt ttt   482
Ala Pro His Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe
            145                 150                 155
 
gga ggt caa aaa ttt atg gaa gat atg atg cca aag gtt gaa act cta   530
Gly Gly Gln Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu
        160                 165                 170
 
aga gct aaa ttt cca cat tta aac att cag gtt gat ggt ggt ttg ggt   578
Arg Ala Lys Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly
    175                 180                 185
 
aaa gaa act att cca aag gct gct aaa gct ggt gct aat gta att gtt   626
Lys Glu Thr Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val
190                 195                 200                 205
 
gct ggt act tca gtt ttt act gct gct gat cca cat gat gta att tct   674
Ala Gly Thr Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser
                210                 215                 220
 
ttt atg aaa gaa gaa gtt tca aaa gaa ttg aga tct aga gat ttg ttg   722
Phe Met Lys Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu
            225                 230                 235
 
gat gaattccgat g                                                  736
Asp

 

<210> 36
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 36
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 37
<211> 742
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(728)

<400> 37
gaatactcca tatg atg gtt aaa cca att att gct cca tct att ttg gct   50
                Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala
                 1               5                   10
 
tct gac ttt gct aat ttg ggt tgt gaa tgt cat aaa gta att aat gct   98
Ser Asp Phe Ala Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala
         15                  20                  25
 
ggt gct gat tgg ttg cat att gat gtt atg gat ggt cat ttc gtt cca   146
Gly Ala Asp Trp Leu His Ile Asp Val Met Asp Gly His Phe Val Pro
     30                  35                  40
 
aat ata act cta ggt caa cca att gtt act tct ttg aga cgt tct gtt   194
Asn Ile Thr Leu Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val
 45                  50                  55                  60
 
cct aga cca ggt gat gca tct aat act gaa aag aag cca act gcg ttc   242
Pro Arg Pro Gly Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe
                 65                  70                  75
 
ttt gat tgt cac atg atg gtt gaa aat cct gaa aaa tgg gtt gat gat   290
Phe Asp Cys His Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp
             80                  85                  90
 
ttt gct aaa tgt ggt gct gat caa ttt act ttt cat tat gaa gca act   338
Phe Ala Lys Cys Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr
         95                 100                 105
 
caa gat cca ttg cat ttg gtt aaa ttg att aaa tct aaa gga att aaa   386
Gln Asp Pro Leu His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys
    110                 115                 120
 
gct gct tgt gct att aag cca ggt act tct gtt gat gtt ttg ttt gaa   434
Ala Ala Cys Ala Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu
125                 130                 135                 140
 
ttg gct cca cat ttg gat atg gct ttg gtt atg act gtt gaa cca ggt   482
Leu Ala Pro His Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly
                145                 150                 155
 
ttt gga ggt caa aaa ttt atg gaa gat atg atg cca aag gtt gaa act   530
Phe Gly Gly Gln Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr
            160                 165                 170
 
cta aga gct aaa ttt cca cat tta aac att cag gtt gat ggt ggt ttg   578
Leu Arg Ala Lys Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu
        175                 180                 185
 
ggt aaa gaa act att cca aag gct gct aaa gct ggt gct aat gta att   626
Gly Lys Glu Thr Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile
    190                 195                 200
 
gtt gct ggt act tca gtt ttt act gct gct gat cca cat gat gta att   674
Val Ala Gly Thr Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile
205                 210                 215                 220
 
tct ttt atg aaa gaa gaa gtt tca aaa gaa ttg aga tct aga gat ttg   722
Ser Phe Met Lys Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu
                225                 230                 235
 
ttg gat actagtcgat gcct                                           742
Leu Asp

 

<210> 38
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 38
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 39
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(714)

<400> 39
atg gtt aaa cct att att gct cca tct att ttg gct tct gat ttc gct   48
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                   10                  15
 
aat ttg gga tgt gaa tgt cat aaa gtt att aat gca gga gct gat tgg   96
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
             20                  25                  30
 
ttg cac att gat gtt atg gat gga cat ttc gtt cca aat ata act tta   144
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
         35                  40                  45
 
gga caa cca att gtt act tca ttg agg aga tct gtt cct aga cca gga   192
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
     50                  55                  60
 
gat gct tct aat act gag aaa aag cca act gca ttc ttt gat tgt cac   240
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
 65                  70                  75                  80
 
atg atg gtt gaa aat cct gaa aag tgg gtt gat gac ttt gca aaa tgt   288
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                 85                  90                  95
 
gga gct gat caa ttt act ttt cat tat gag gct act caa gat cca ttg   336
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110
 
cat ttg gtt aaa ttg att aaa tct aaa gga att aaa gct gct tgt gct   384
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125
 
att aaa cct gga aca tct gtt gac gtt ttg ttt gag ttg gct cca cat   432
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140
 
ttg gat atg gct ttg gtt atg act gtt gaa cca gga ttc gga gga caa   480
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160
 
aaa ttt atg gaa gat atg atg cca aaa gtt gaa aca ttg aga gct aaa   528
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175
 
ttt cca cat tta aac att caa gtt gat gga gga ttg gga aaa gaa act   576
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190
 
att cca aaa gcc gct aaa gct gga gct aat gtt att gtt gct ggt act   624
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205
 
tct gtt ttt act gct gct gat cca cat gat gtt att tct ttt atg aaa   672
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220
 
gaa gaa gtt tct aaa gaa ttg aga tct aga gat ttg ttg gat           714
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235
 


<210> 40
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 40
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 41
<211> 736
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(725)

<400> 41
tactcaagct t atg gtt aaa cct att att gct cca tct att ttg gct tct  50
             Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser
              1               5                   10
 
gat ttc gct aat ttg gga tgt gaa tgt cat aaa gtt att aat gca gga   98
Asp Phe Ala Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly
     15                  20                  25
 
gct gat tgg ttg cac att gat gtt atg gat gga cat ttc gtt cca aat   146
Ala Asp Trp Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn
 30                  35                  40                  45
 
ata act tta gga caa cca att gtt act tca ttg agg aga tct gtt cct   194
Ile Thr Leu Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro
                 50                  55                  60
 
aga cca gga gat gct tct aat act gag aaa aag cca act gca ttc ttt   242
Arg Pro Gly Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe
             65                  70                  75
 
gat tgt cac atg atg gtt gaa aat cct gaa aag tgg gtt gat gac ttt   290
Asp Cys His Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe
         80                  85                  90
 
gca aaa tgt gga gct gat caa ttt act ttt cat tat gag gct act caa   338
Ala Lys Cys Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln
     95                 100                 105
 
gat cca ttg cat ttg gtt aaa ttg att aaa tct aaa gga att aaa gct   386
Asp Pro Leu His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala
110                 115                 120                 125
 
gct tgt gct att aaa cct gga aca tct gtt gac gtt ttg ttt gag ttg   434
Ala Cys Ala Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu
                130                 135                 140
 
gct cca cat ttg gat atg gct ttg gtt atg act gtt gaa cca gga ttc   482
Ala Pro His Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe
            145                 150                 155
 
gga gga caa aaa ttt atg gaa gat atg atg cca aaa gtt gaa aca ttg   530
Gly Gly Gln Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu
        160                 165                 170
 
aga gct aaa ttt cca cat tta aac att caa gtt gat gga gga ttg gga   578
Arg Ala Lys Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly
    175                 180                 185
 
aaa gaa act att cca aaa gcc gct aaa gct gga gct aat gtt att gtt   626
Lys Glu Thr Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val
190                 195                 200                 205
 
gct ggt act tct gtt ttt act gct gct gat cca cat gat gtt att tct   674
Ala Gly Thr Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser
                210                 215                 220
 
ttt atg aaa gaa gaa gtt tct aaa gaa ttg aga tct aga gat ttg ttg   722
Phe Met Lys Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu
            225                 230                 235
 
gat gaattccgat g                                                  736
Asp

 

<210> 42
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 42
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 43
<211> 742
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(728)

<400> 43
gaatactcca tatg atg gtt aaa cct att att gct cca tct att ttg gct   50
                Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala
                 1               5                   10
 
tct gat ttc gct aat ttg gga tgt gaa tgt cat aaa gtt att aat gca   98
Ser Asp Phe Ala Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala
         15                  20                  25
 
gga gct gat tgg ttg cac att gat gtt atg gat gga cat ttc gtt cca   146
Gly Ala Asp Trp Leu His Ile Asp Val Met Asp Gly His Phe Val Pro
     30                  35                  40
 
aat ata act tta gga caa cca att gtt act tca ttg agg aga tct gtt   194
Asn Ile Thr Leu Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val
 45                  50                  55                  60
 
cct aga cca gga gat gct tct aat act gag aaa aag cca act gca ttc   242
Pro Arg Pro Gly Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe
                 65                  70                  75
 
ttt gat tgt cac atg atg gtt gaa aat cct gaa aag tgg gtt gat gac   290
Phe Asp Cys His Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp
             80                  85                  90
 
ttt gca aaa tgt gga gct gat caa ttt act ttt cat tat gag gct act   338
Phe Ala Lys Cys Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr
         95                 100                 105
 
caa gat cca ttg cat ttg gtt aaa ttg att aaa tct aaa gga att aaa   386
Gln Asp Pro Leu His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys
    110                 115                 120
 
gct gct tgt gct att aaa cct gga aca tct gtt gac gtt ttg ttt gag   434
Ala Ala Cys Ala Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu
125                 130                 135                 140
 
ttg gct cca cat ttg gat atg gct ttg gtt atg act gtt gaa cca gga   482
Leu Ala Pro His Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly
                145                 150                 155
 
ttc gga gga caa aaa ttt atg gaa gat atg atg cca aaa gtt gaa aca   530
Phe Gly Gly Gln Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr
            160                 165                 170
 
ttg aga gct aaa ttt cca cat tta aac att caa gtt gat gga gga ttg   578
Leu Arg Ala Lys Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu
        175                 180                 185
 
gga aaa gaa act att cca aaa gcc gct aaa gct gga gct aat gtt att   626
Gly Lys Glu Thr Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile
    190                 195                 200
 
gtt gct ggt act tct gtt ttt act gct gct gat cca cat gat gtt att   674
Val Ala Gly Thr Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile
205                 210                 215                 220
 
tct ttt atg aaa gaa gaa gtt tct aaa gaa ttg aga tct aga gat ttg   722
Ser Phe Met Lys Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu
                225                 230                 235
 
ttg gat actagtcgat gcct                                           742
Leu Asp

 

<210> 44
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 44
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 45
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(714)

<400> 45
atg gtt aaa cca att att gct cca tct att ttg gct tca gat ttc gct   48
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                   10                  15
 
aat ttg ggt tgt gaa tgt cat aaa gtt att aat gct ggt gct gat tgg   96
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
             20                  25                  30
 
ttg cat att gat gtt atg gat ggt cat ttt gtg cca aat att aca ttg   144
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
         35                  40                  45
 
ggt caa cca att gtt act tca ttg agg aga tct gtt cct aga cca ggt   192
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
     50                  55                  60
 
gat gct tct aat act gaa aaa aaa cca act gct ttc ttc gat tgt cac   240
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
 65                  70                  75                  80
 
atg atg gtt gaa aat cca gaa aag tgg gtt gat gat ttc gca aaa tgt   288
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                 85                  90                  95
 
ggt gcg gat caa ttc act ttc cac tat gag gca acc caa gat cca ttg   336
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110
 
cat ttg gtt aaa ttg att aaa tct aaa gga att aaa gct gct tgt gct   384
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125
 
att aaa cca ggt aca tca gtt gat gtt ttg ttc gaa ttg gct cca cat   432
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140
 
ttg gat atg gct ttg gtt atg act gtt gaa cca ggt ttc ggt ggt caa   480
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160
 
aaa ttc atg gaa gat atg atg cca aaa gtt gaa aca ttg aga gct aaa   528
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175
 
ttc cct cat tta aac atc caa gtt gat ggt ggt ttg gga aaa gaa act   576
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190
 
att cca aaa gca gcc aaa gct ggg gcg aat gtt att gtt gct gga act   624
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205
 
tct gtt ttc act gct gcc gac cca cat gat gtt att tct ttc atg aag   672
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220
 
gaa gaa gtt tct aaa gaa ttg aga tcg aga gat ttg ttg gat           714
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235
 


<210> 46
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 46
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 47
<211> 714
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(714)

<400> 47
atg gtt aaa ccg att att gcc ccg tct att ttg gcc tct gat ttt gct   48
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                   10                  15
 
aat ttg ggt tgt gaa tgt cat aaa gtc att aat gct ggt gcc gat tgg   96
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
             20                  25                  30
 
ttg cat att gat gtt atg gat ggt cat ttt gtt ccg aat att acc ttg   144
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
         35                  40                  45
 
ggt cag ccg ata gtt acc tct ttg cgt cgt tct gtt ccg cgt ccg ggt   192
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
     50                  55                  60
 
gat gct tct aat acc gaa aag aaa ccg acc gcc ttc ttc gat tgt cac   240
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
 65                  70                  75                  80
 
atg atg gtt gaa aat ccg gaa aaa tgg gtt gat gat ttt gcc aaa tgt   288
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                 85                  90                  95
 
ggt gca gac cag ttt acc ttt cat tat gag gcg acc cag gat ccg ttg   336
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110
 
cat ttg gtt aaa ttg att aaa tct aaa ggg atc aaa gcc gct tgt gcc   384
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125
 
att aaa ccg ggc acc tct gtt gac gtt ttg ttt gaa ttg gcc cct cat   432
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140
 
ttg gat atg gcc ctt gtt atg acc gtt gaa cct ggt ttt ggt ggt cag   480
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160
 
aaa ttt atg gaa gat atg atg ccg aaa gtt gaa acc ttg cga gcc aaa   528
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175
 
ttt ccg cat ctc aat att cag gtt gat ggt gga ttg ggt aaa gaa acc   576
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190
 
att ccg aaa gca gcc aaa gct gga gct aat gtc att gtt gct ggg acg   624
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205
 
tct gtt ttt acc gct gca gat ccg cac gac gtt atc tct ttt atg aaa   672
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220
 
gaa gaa gtt tct aaa gaa ttg cgt tct cgt gat ttg ttg gat           714
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235
 


<210> 48
<211> 238
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 48
Met Val Lys Pro Ile Ile Ala Pro Ser Ile Leu Ala Ser Asp Phe Ala
 1               5                  10                  15      
Asn Leu Gly Cys Glu Cys His Lys Val Ile Asn Ala Gly Ala Asp Trp
            20                  25                  30          
Leu His Ile Asp Val Met Asp Gly His Phe Val Pro Asn Ile Thr Leu
        35                  40                  45              
Gly Gln Pro Ile Val Thr Ser Leu Arg Arg Ser Val Pro Arg Pro Gly
    50                  55                  60                  
Asp Ala Ser Asn Thr Glu Lys Lys Pro Thr Ala Phe Phe Asp Cys His
65                  70                  75                  80  
Met Met Val Glu Asn Pro Glu Lys Trp Val Asp Asp Phe Ala Lys Cys
                85                  90                  95      
Gly Ala Asp Gln Phe Thr Phe His Tyr Glu Ala Thr Gln Asp Pro Leu
            100                 105                 110         
His Leu Val Lys Leu Ile Lys Ser Lys Gly Ile Lys Ala Ala Cys Ala
        115                 120                 125             
Ile Lys Pro Gly Thr Ser Val Asp Val Leu Phe Glu Leu Ala Pro His
    130                 135                 140                 
Leu Asp Met Ala Leu Val Met Thr Val Glu Pro Gly Phe Gly Gly Gln
145                 150                 155                 160 
Lys Phe Met Glu Asp Met Met Pro Lys Val Glu Thr Leu Arg Ala Lys
                165                 170                 175     
Phe Pro His Leu Asn Ile Gln Val Asp Gly Gly Leu Gly Lys Glu Thr
            180                 185                 190         
Ile Pro Lys Ala Ala Lys Ala Gly Ala Asn Val Ile Val Ala Gly Thr
        195                 200                 205             
Ser Val Phe Thr Ala Ala Asp Pro His Asp Val Ile Ser Phe Met Lys
    210                 215                 220                 
Glu Glu Val Ser Lys Glu Leu Arg Ser Arg Asp Leu Leu Asp
225                 230                 235             


<210> 49
<211> 1047
<212> DNA
<213> S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1047)

<400> 49
atg tct atc cca gaa act caa aaa ggt gtt atc ttc tac gaa tcc cac   48
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                   10                  15
 
ggt aag ttg gaa tac aaa gat att cca gtt cca aag cca aag gcc aac   96
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
             20                  25                  30
 
gaa ttg ttg atc aac gtt aaa tac tct ggt gtc tgt cac act gac ttg   144
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
         35                  40                  45
 
cac gct tgg cac ggt gac tgg cca ttg cca gtt aag cta cca tta gtc   192
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
     50                  55                  60
 
ggt ggt cac gaa ggt gcc ggt gtc gtt gtc ggc atg ggt gaa aac gtt   240
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
 65                  70                  75                  80
 
aag ggc tgg aag atc ggt gac tac gcc ggt atc aaa tgg ttg aac ggt   288
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                 85                  90                  95
 
tct tgt atg gcc tgt gaa tac tgt gaa ttg ggt aac gaa tcc aac tgt   336
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110
 
cct cac gct gac ttg tct ggt tac acc cac gac ggt tct ttc caa caa   384
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125
 
tac gct acc gct gac gct gtt caa gcc gct cac att cct caa ggt acc   432
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140
 
gac ttg gcc caa gtc gcc ccc atc ttg tgt gct ggt atc acc gtc tac   480
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160
 
aag gct ttg aag tct gct aac ttg atg gcc ggt cac tgg gtt gct atc   528
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175
 
tcc ggt gct gct ggt ggt cta ggt tct ttg gct gtt caa tac gcc aag   576
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190
 
gct atg ggt tac aga gtc ttg ggt att gac ggt ggt gaa ggt aag gaa   624
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205
 
gaa tta ttc aga tcc atc ggt ggt gaa gtc ttc att gac ttc act aag   672
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220
 
gaa aag gac att gtc ggt gct gtt cta aag gcc act gac ggt ggt gct   720
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240
 
cac ggt gtc atc aac gtt tcc gtt tcc gaa gcc gct att gaa gct tct   768
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255
 
acc aga tac gtt aga gct aac ggt acc acc gtt ttg gtc ggt atg cca   816
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270
 
gct ggt gcc aag tgt tgt tct gat gtc ttc aac caa gtc gtc aag tcc   864
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285
 
atc tct att gtt ggt tct tac gtc ggt aac aga gct gac acc aga gaa   912
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300
 
gct ttg gac ttc ttc gcc aga ggt ttg gtc aag tct cca atc aag gtt   960
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320
 
gtc ggc ttg tct acc ttg cca gaa att tac gaa aag atg gaa aag ggt   1008
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335
 
caa atc gtt ggt aga tac gtt gtt gac act tct aaa taa               1047
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys  *
            340                 345
 

<210> 50
<211> 348
<212> PRT
<213> S. cerevisiae

<400> 50
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 51
<211> 1044
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1044)

<400> 51
atg tct att cca gaa act caa aaa ggt gta att ttc tat gaa tct cat   48
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                   10                  15
 
ggt aaa ttg gaa tat aaa gat ata cca gtt cca aaa cca aaa gct aat   96
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
             20                  25                  30
 
gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt cat act gat ttg   144
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
         35                  40                  45
 
cac gct tgg cat ggt gat tgg cct tta cca gtt aaa ttg cca ttg gtt   192
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
     50                  55                  60
 
ggt ggt cat gaa gga gct ggt gtt gtt gtt ggt atg ggt gaa aat gtt   240
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
 65                  70                  75                  80
 
aaa ggt tgg aaa att ggt gat tat gct gga att aaa tgg tta aat ggt   288
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                 85                  90                  95
 
tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat gaa tct aat tgt   336
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110
 
cca cat gct gac ttg tct ggt tat act cat gat ggt tct ttt caa caa   384
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125
 
tat gct acc gca gat gct gtt caa gct gct cat att cca caa ggt act   432
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140
 
gat ttg gct caa gta gct cca att ttg tgt gct gga att act gtt tat   480
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160
 
aaa gct cta aaa tct gct aat ttg atg gcg ggt cat tgg gta gct att   528
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175
 
tct ggt gct gct ggt ggt ttg ggt tct ttg gca gta caa tat gct aaa   576
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190
 
gct atg ggt tat aga gtt ttg gga ata gat gga ggt gaa ggt aaa gaa   624
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205
 
gaa ttg ttt aga tct ata ggt ggt gag gtt ttt att gat ttt act aaa   672
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220
 
gaa aaa gat ata gtt ggt gca gtt tta aaa gct aca gat ggt ggt gct   720
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240
 
cat ggt gta att aat gtt tca gtt tca gaa gct gct att gaa gct agt   768
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255
 
act aga tat gtt aga gct aat ggt act act gtt ttg gtt ggt atg cca   816
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270
 
gca ggt gct aaa tgt tgt tct gat gtt ttt aat caa gtt gtt aaa tct   864
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285
 
att tct att gtt ggt tct tat gtt ggt aat aga gct gat act aga gaa   912
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300
 
gca ttg gat ttc ttt gct aga gga ttg gtt aaa tca ccc att aaa gta   960
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320
 
gtt ggt ttg tct aca ttg cca gaa att tat gaa aag atg gaa aaa ggt   1008
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335
 
caa att gta ggt aga tat gtt gtt gat act tct aaa                   1044
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345
 

<210> 52
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 52
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 53
<211> 1066
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1055)

<400> 53
tactcaagct t atg tct att cca gaa act caa aaa ggt gta att ttc tat  50
             Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr
              1               5                   10
 
gaa tct cat ggt aaa ttg gaa tat aaa gat ata cca gtt cca aaa cca   98
Glu Ser His Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro
     15                  20                  25
 
aaa gct aat gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt cat   146
Lys Ala Asn Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His
 30                  35                  40                  45
 
act gat ttg cac gct tgg cat ggt gat tgg cct tta cca gtt aaa ttg   194
Thr Asp Leu His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu
                 50                  55                  60
 
cca ttg gtt ggt ggt cat gaa gga gct ggt gtt gtt gtt ggt atg ggt   242
Pro Leu Val Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly
             65                  70                  75
 
gaa aat gtt aaa ggt tgg aaa att ggt gat tat gct gga att aaa tgg   290
Glu Asn Val Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp
         80                  85                  90
 
tta aat ggt tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat gaa   338
Leu Asn Gly Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu
     95                 100                 105
 
tct aat tgt cca cat gct gac ttg tct ggt tat act cat gat ggt tct   386
Ser Asn Cys Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser
110                 115                 120                 125
 
ttt caa caa tat gct acc gca gat gct gtt caa gct gct cat att cca   434
Phe Gln Gln Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro
                130                 135                 140
 
caa ggt act gat ttg gct caa gta gct cca att ttg tgt gct gga att   482
Gln Gly Thr Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile
            145                 150                 155
 
act gtt tat aaa gct cta aaa tct gct aat ttg atg gcg ggt cat tgg   530
Thr Val Tyr Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp
        160                 165                 170
 
gta gct att tct ggt gct gct ggt ggt ttg ggt tct ttg gca gta caa   578
Val Ala Ile Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln
    175                 180                 185
 
tat gct aaa gct atg ggt tat aga gtt ttg gga ata gat gga ggt gaa   626
Tyr Ala Lys Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu
190                 195                 200                 205
 
ggt aaa gaa gaa ttg ttt aga tct ata ggt ggt gag gtt ttt att gat   674
Gly Lys Glu Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp
                210                 215                 220
 
ttt act aaa gaa aaa gat ata gtt ggt gca gtt tta aaa gct aca gat   722
Phe Thr Lys Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp
            225                 230                 235
 
ggt ggt gct cat ggt gta att aat gtt tca gtt tca gaa gct gct att   770
Gly Gly Ala His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile
        240                 245                 250
 
gaa gct agt act aga tat gtt aga gct aat ggt act act gtt ttg gtt   818
Glu Ala Ser Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val
    255                 260                 265
 
ggt atg cca gca ggt gct aaa tgt tgt tct gat gtt ttt aat caa gtt   866
Gly Met Pro Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val
270                 275                 280                 285
 
gtt aaa tct att tct att gtt ggt tct tat gtt ggt aat aga gct gat   914
Val Lys Ser Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp
                290                 295                 300
 
act aga gaa gca ttg gat ttc ttt gct aga gga ttg gtt aaa tca ccc   962
Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro
            305                 310                 315
 
att aaa gta gtt ggt ttg tct aca ttg cca gaa att tat gaa aag atg   1010
Ile Lys Val Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met
        320                 325                 330
 
gaa aaa ggt caa att gta ggt aga tat gtt gtt gat act tct aaa       1055
Glu Lys Gly Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
    335                 340                 345
 
gaattccgat g                                                      1066

<210> 54
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 54
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 55
<211> 1072
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1058)

<400> 55
gaatactcca tatg atg tct att cca gaa act caa aaa ggt gta att ttc   50
                Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe
                 1               5                   10
 
tat gaa tct cat ggt aaa ttg gaa tat aaa gat ata cca gtt cca aaa   98
Tyr Glu Ser His Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys
         15                  20                  25
 
cca aaa gct aat gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt   146
Pro Lys Ala Asn Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys
     30                  35                  40
 
cat act gat ttg cac gct tgg cat ggt gat tgg cct tta cca gtt aaa   194
His Thr Asp Leu His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys
 45                  50                  55                  60
 
ttg cca ttg gtt ggt ggt cat gaa gga gct ggt gtt gtt gtt ggt atg   242
Leu Pro Leu Val Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met
                 65                  70                  75
 
ggt gaa aat gtt aaa ggt tgg aaa att ggt gat tat gct gga att aaa   290
Gly Glu Asn Val Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys
             80                  85                  90
 
tgg tta aat ggt tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat   338
Trp Leu Asn Gly Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn
         95                 100                 105
 
gaa tct aat tgt cca cat gct gac ttg tct ggt tat act cat gat ggt   386
Glu Ser Asn Cys Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly
    110                 115                 120
 
tct ttt caa caa tat gct acc gca gat gct gtt caa gct gct cat att   434
Ser Phe Gln Gln Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile
125                 130                 135                 140
 
cca caa ggt act gat ttg gct caa gta gct cca att ttg tgt gct gga   482
Pro Gln Gly Thr Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly
                145                 150                 155
 
att act gtt tat aaa gct cta aaa tct gct aat ttg atg gcg ggt cat   530
Ile Thr Val Tyr Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His
            160                 165                 170
 
tgg gta gct att tct ggt gct gct ggt ggt ttg ggt tct ttg gca gta   578
Trp Val Ala Ile Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val
        175                 180                 185
 
caa tat gct aaa gct atg ggt tat aga gtt ttg gga ata gat gga ggt   626
Gln Tyr Ala Lys Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly
    190                 195                 200
 
gaa ggt aaa gaa gaa ttg ttt aga tct ata ggt ggt gag gtt ttt att   674
Glu Gly Lys Glu Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile
205                 210                 215                 220
 
gat ttt act aaa gaa aaa gat ata gtt ggt gca gtt tta aaa gct aca   722
Asp Phe Thr Lys Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr
                225                 230                 235
 
gat ggt ggt gct cat ggt gta att aat gtt tca gtt tca gaa gct gct   770
Asp Gly Gly Ala His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala
            240                 245                 250
 
att gaa gct agt act aga tat gtt aga gct aat ggt act act gtt ttg   818
Ile Glu Ala Ser Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu
        255                 260                 265
 
gtt ggt atg cca gca ggt gct aaa tgt tgt tct gat gtt ttt aat caa   866
Val Gly Met Pro Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln
    270                 275                 280
 
gtt gtt aaa tct att tct att gtt ggt tct tat gtt ggt aat aga gct   914
Val Val Lys Ser Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala
285                 290                 295                 300
 
gat act aga gaa gca ttg gat ttc ttt gct aga gga ttg gtt aaa tca   962
Asp Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser
                305                 310                 315
 
ccc att aaa gta gtt ggt ttg tct aca ttg cca gaa att tat gaa aag   1010
Pro Ile Lys Val Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys
            320                 325                 330
 
atg gaa aaa ggt caa att gta ggt aga tat gtt gtt gat act tct aaa   1058
Met Glu Lys Gly Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
        335                 340                 345
 
actagtcgat gcct                                                   1072

<210> 56
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 56
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 57
<211> 1044
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1044)

<400> 57
atg tct att cca gaa act caa aaa ggt gta att ttc tat gaa tct cat   48
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                   10                  15
 
ggt aaa ttg gaa tat aaa gat ata cca gtt cca aaa cca aaa gct aat   96
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
             20                  25                  30
 
gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt cat act gat ttg   144
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
         35                  40                  45
 
cac gct tgg cat ggt gat tgg cct tta cca gtt aaa ttg cca ttg gtt   192
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
     50                  55                  60
 
ggt ggt cat gaa gga gct ggt gtt gtt gtt ggt atg ggt gaa aat gtt   240
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
 65                  70                  75                  80
 
aaa ggt tgg aaa att ggt gat tat gct gga att aaa tgg tta aat ggt   288
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                 85                  90                  95
 
tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat gaa tct aat tgt   336
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110
 
cca cat gct gac ttg tct ggt tat act cat gat ggt tct ttt caa caa   384
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125
 
tat gct acc gca gat gct gtt caa gct gct cat att cca caa ggt act   432
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140
 
gat ttg gct caa gta gct cca att ttg tgt gct gga att act gtt tat   480
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160
 
aaa gct cta aaa tct gct aat ttg atg gcg ggt cat tgg gta gct att   528
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175
 
tct ggt gct gct ggt ggt ttg ggt tct ttg gca gta caa tat gct aaa   576
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190
 
gct atg ggt tat aga gtt ttg gga ata gat gga ggt gaa ggt aaa gaa   624
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205
 
gaa ttg ttt aga tct ata ggt ggt gag gtt ttt att gat ttt act aaa   672
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220
 
gaa aaa gat ata gtt ggt gca gtt tta aaa gct aca gat ggt ggt gct   720
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240
 
cat ggt gta att aat gtt tca gtt tca gaa gct gct att gaa gct agt   768
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255
 
act aga tat gtt aga gct aat ggt act act gtt ttg gtt ggt atg cca   816
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270
 
gca ggt gct aaa tgt tgt tct gat gtt ttt aat caa gtt gtt aaa tct   864
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285
 
att tct att gtt ggt tct tat gtt ggt aat aga gct gat act aga gaa   912
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300
 
gca ttg gat ttc ttt gct aga gga ttg gtt aaa tca ccc att aaa gta   960
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320
 
gtt ggt ttg tct aca ttg cca gaa att tat gaa aag atg gaa aaa ggt   1008
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335
 
caa att gta ggt aga tat gtt gtt gat act tct aaa                   1044
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345
 

<210> 58
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 58
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 59
<211> 1066
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1055)

<400> 59
tactcaagct t atg tct att cca gaa act caa aaa ggt gta att ttc tat  50
             Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr
              1               5                   10
 
gaa tct cat ggt aaa ttg gaa tat aaa gat ata cca gtt cca aaa cca   98
Glu Ser His Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro
     15                  20                  25
 
aaa gct aat gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt cat   146
Lys Ala Asn Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His
 30                  35                  40                  45
 
act gat ttg cac gct tgg cat ggt gat tgg cct tta cca gtt aaa ttg   194
Thr Asp Leu His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu
                 50                  55                  60
 
cca ttg gtt ggt ggt cat gaa gga gct ggt gtt gtt gtt ggt atg ggt   242
Pro Leu Val Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly
             65                  70                  75
 
gaa aat gtt aaa ggt tgg aaa att ggt gat tat gct gga att aaa tgg   290
Glu Asn Val Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp
         80                  85                  90
 
tta aat ggt tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat gaa   338
Leu Asn Gly Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu
     95                 100                 105
 
tct aat tgt cca cat gct gac ttg tct ggt tat act cat gat ggt tct   386
Ser Asn Cys Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser
110                 115                 120                 125
 
ttt caa caa tat gct acc gca gat gct gtt caa gct gct cat att cca   434
Phe Gln Gln Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro
                130                 135                 140
 
caa ggt act gat ttg gct caa gta gct cca att ttg tgt gct gga att   482
Gln Gly Thr Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile
            145                 150                 155
 
act gtt tat aaa gct cta aaa tct gct aat ttg atg gcg ggt cat tgg   530
Thr Val Tyr Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp
        160                 165                 170
 
gta gct att tct ggt gct gct ggt ggt ttg ggt tct ttg gca gta caa   578
Val Ala Ile Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln
    175                 180                 185
 
tat gct aaa gct atg ggt tat aga gtt ttg gga ata gat gga ggt gaa   626
Tyr Ala Lys Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu
190                 195                 200                 205
 
ggt aaa gaa gaa ttg ttt aga tct ata ggt ggt gag gtt ttt att gat   674
Gly Lys Glu Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp
                210                 215                 220
 
ttt act aaa gaa aaa gat ata gtt ggt gca gtt tta aaa gct aca gat   722
Phe Thr Lys Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp
            225                 230                 235
 
ggt ggt gct cat ggt gta att aat gtt tca gtt tca gaa gct gct att   770
Gly Gly Ala His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile
        240                 245                 250
 
gaa gct agt act aga tat gtt aga gct aat ggt act act gtt ttg gtt   818
Glu Ala Ser Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val
    255                 260                 265
 
ggt atg cca gca ggt gct aaa tgt tgt tct gat gtt ttt aat caa gtt   866
Gly Met Pro Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val
270                 275                 280                 285
 
gtt aaa tct att tct att gtt ggt tct tat gtt ggt aat aga gct gat   914
Val Lys Ser Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp
                290                 295                 300
 
act aga gaa gca ttg gat ttc ttt gct aga gga ttg gtt aaa tca ccc   962
Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro
            305                 310                 315
 
att aaa gta gtt ggt ttg tct aca ttg cca gaa att tat gaa aag atg   1010
Ile Lys Val Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met
        320                 325                 330
 
gaa aaa ggt caa att gta ggt aga tat gtt gtt gat act tct aaa       1055
Glu Lys Gly Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
    335                 340                 345
 
gaattccgat g                                                      1066

<210> 60
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 60
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 61
<211> 1072
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1058)

<400> 61
gaatactcca tatg atg tct att cca gaa act caa aaa ggt gta att ttc   50
                Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe
                 1               5                   10
 
tat gaa tct cat ggt aaa ttg gaa tat aaa gat ata cca gtt cca aaa   98
Tyr Glu Ser His Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys
         15                  20                  25
 
cca aaa gct aat gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt   146
Pro Lys Ala Asn Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys
     30                  35                  40
 
cat act gat ttg cac gct tgg cat ggt gat tgg cct tta cca gtt aaa   194
His Thr Asp Leu His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys
 45                  50                  55                  60
 
ttg cca ttg gtt ggt ggt cat gaa gga gct ggt gtt gtt gtt ggt atg   242
Leu Pro Leu Val Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met
                 65                  70                  75
 
ggt gaa aat gtt aaa ggt tgg aaa att ggt gat tat gct gga att aaa   290
Gly Glu Asn Val Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys
             80                  85                  90
 
tgg tta aat ggt tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat   338
Trp Leu Asn Gly Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn
         95                 100                 105
 
gaa tct aat tgt cca cat gct gac ttg tct ggt tat act cat gat ggt   386
Glu Ser Asn Cys Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly
    110                 115                 120
 
tct ttt caa caa tat gct acc gca gat gct gtt caa gct gct cat att   434
Ser Phe Gln Gln Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile
125                 130                 135                 140
 
cca caa ggt act gat ttg gct caa gta gct cca att ttg tgt gct gga   482
Pro Gln Gly Thr Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly
                145                 150                 155
 
att act gtt tat aaa gct cta aaa tct gct aat ttg atg gcg ggt cat   530
Ile Thr Val Tyr Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His
            160                 165                 170
 
tgg gta gct att tct ggt gct gct ggt ggt ttg ggt tct ttg gca gta   578
Trp Val Ala Ile Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val
        175                 180                 185
 
caa tat gct aaa gct atg ggt tat aga gtt ttg gga ata gat gga ggt   626
Gln Tyr Ala Lys Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly
    190                 195                 200
 
gaa ggt aaa gaa gaa ttg ttt aga tct ata ggt ggt gag gtt ttt att   674
Glu Gly Lys Glu Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile
205                 210                 215                 220
 
gat ttt act aaa gaa aaa gat ata gtt ggt gca gtt tta aaa gct aca   722
Asp Phe Thr Lys Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr
                225                 230                 235
 
gat ggt ggt gct cat ggt gta att aat gtt tca gtt tca gaa gct gct   770
Asp Gly Gly Ala His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala
            240                 245                 250
 
att gaa gct agt act aga tat gtt aga gct aat ggt act act gtt ttg   818
Ile Glu Ala Ser Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu
        255                 260                 265
 
gtt ggt atg cca gca ggt gct aaa tgt tgt tct gat gtt ttt aat caa   866
Val Gly Met Pro Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln
    270                 275                 280
 
gtt gtt aaa tct att tct att gtt ggt tct tat gtt ggt aat aga gct   914
Val Val Lys Ser Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala
285                 290                 295                 300
 
gat act aga gaa gca ttg gat ttc ttt gct aga gga ttg gtt aaa tca   962
Asp Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser
                305                 310                 315
 
ccc att aaa gta gtt ggt ttg tct aca ttg cca gaa att tat gaa aag   1010
Pro Ile Lys Val Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys
            320                 325                 330
 
atg gaa aaa ggt caa att gta ggt aga tat gtt gtt gat act tct aaa   1058
Met Glu Lys Gly Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
        335                 340                 345
 
actagtcgat gcct                                                   1072

<210> 62
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 62
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 63
<211> 1044
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1044)

<400> 63
atg tct att cca gag act caa aaa gga gtt atc ttt tat gaa tct cat   48
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                   10                  15
 
gga aaa tta gaa tat aaa gac att cca gtt cca aaa cct aaa gct aat   96
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
             20                  25                  30
 
gaa ttg ttg att aat gtt aaa tat tct gga gtt tgt cat act gat ttg   144
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
         35                  40                  45
 
cac gct tgg cat gga gat tgg cct tta cca gtt aaa ttg cct ttg gtt   192
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
     50                  55                  60
 
gga gga cat gaa gga gct gga gtt gtt gtt gga atg gga gaa aat gtt   240
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
 65                  70                  75                  80
 
aaa gga tgg aaa att gga gat tat gct gga att aag tgg tta aat gga   288
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                 85                  90                  95
 
tct tgt atg gct tgt gaa tat tgt gaa ttg gga aat gaa tct aat tgt   336
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110
 
cca cat gct gat tta tct gga tat act cat gat gga tct ttt caa caa   384
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125
 
tat gct act gct gat gct gtt caa gcc gct cat atc cca caa gga aca   432
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140
 
gat ttg gct caa gtt gct cca att tta tgt gct gga att act gtt tat   480
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160
 
aaa gct ctt aaa tct gct aat ttg atg gct gga cat tgg gtt gct att   528
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175
 
tct ggt gca gct ggt gga ctt gga tca ttg gca gtt caa tat gct aaa   576
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190
 
gct atg gga tat aga gtt ttg gga att gat gga ggt gaa gga aaa gaa   624
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205
 
gaa ttg ttt aga tct atc gga gga gag gtt ttt att gat ttt act aaa   672
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220
 
gaa aaa gat ata gtt gga gct gtt tta aaa gca aca gac gga ggt gct   720
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240
 
cat gga gtt att aat gtt tct gtt tct gag gct gct att gag gct tct   768
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255
 
act aga tat gtt aga gct aat ggt act act gtt ttg gtt gga atg cca   816
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270
 
gca gga gca aaa tgt tgt tct gat gtt ttt aat caa gtt gtt aaa tct   864
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285
 
att tct atc gtt gga tct tat gtt gga aat aga gct gat act aga gag   912
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300
 
gct ttg gat ttc ttt gca aga ggt ttg gtt aaa tct cca att aaa gtt   960
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320
 
gtt gga ttg tct aca ttg cca gaa att tat gaa aag atg gaa aaa gga   1008
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335
 
caa att gtt ggt aga tat gtt gtt gat act tct aaa                   1044
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345
 

<210> 64
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 64
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 65
<211> 1066
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1055)

<400> 65
tactcaagct t atg tct att cca gag act caa aaa gga gtt atc ttt tat  50
             Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr
              1               5                   10
 
gaa tct cat gga aaa tta gaa tat aaa gac att cca gtt cca aaa cct   98
Glu Ser His Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro
     15                  20                  25
 
aaa gct aat gaa ttg ttg att aat gtt aaa tat tct gga gtt tgt cat   146
Lys Ala Asn Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His
 30                  35                  40                  45
 
act gat ttg cac gct tgg cat gga gat tgg cct tta cca gtt aaa ttg   194
Thr Asp Leu His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu
                 50                  55                  60
 
cct ttg gtt gga gga cat gaa gga gct gga gtt gtt gtt gga atg gga   242
Pro Leu Val Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly
             65                  70                  75
 
gaa aat gtt aaa gga tgg aaa att gga gat tat gct gga att aag tgg   290
Glu Asn Val Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp
         80                  85                  90
 
tta aat gga tct tgt atg gct tgt gaa tat tgt gaa ttg gga aat gaa   338
Leu Asn Gly Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu
     95                 100                 105
 
tct aat tgt cca cat gct gat tta tct gga tat act cat gat gga tct   386
Ser Asn Cys Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser
110                 115                 120                 125
 
ttt caa caa tat gct act gct gat gct gtt caa gcc gct cat atc cca   434
Phe Gln Gln Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro
                130                 135                 140
 
caa gga aca gat ttg gct caa gtt gct cca att tta tgt gct gga att   482
Gln Gly Thr Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile
            145                 150                 155
 
act gtt tat aaa gct ctt aaa tct gct aat ttg atg gct gga cat tgg   530
Thr Val Tyr Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp
        160                 165                 170
 
gtt gct att tct ggt gca gct ggt gga ctt gga tca ttg gca gtt caa   578
Val Ala Ile Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln
    175                 180                 185
 
tat gct aaa gct atg gga tat aga gtt ttg gga att gat gga ggt gaa   626
Tyr Ala Lys Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu
190                 195                 200                 205
 
gga aaa gaa gaa ttg ttt aga tct atc gga gga gag gtt ttt att gat   674
Gly Lys Glu Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp
                210                 215                 220
 
ttt act aaa gaa aaa gat ata gtt gga gct gtt tta aaa gca aca gac   722
Phe Thr Lys Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp
            225                 230                 235
 
gga ggt gct cat gga gtt att aat gtt tct gtt tct gag gct gct att   770
Gly Gly Ala His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile
        240                 245                 250
 
gag gct tct act aga tat gtt aga gct aat ggt act act gtt ttg gtt   818
Glu Ala Ser Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val
    255                 260                 265
 
gga atg cca gca gga gca aaa tgt tgt tct gat gtt ttt aat caa gtt   866
Gly Met Pro Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val
270                 275                 280                 285
 
gtt aaa tct att tct atc gtt gga tct tat gtt gga aat aga gct gat   914
Val Lys Ser Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp
                290                 295                 300
 
act aga gag gct ttg gat ttc ttt gca aga ggt ttg gtt aaa tct cca   962
Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro
            305                 310                 315
 
att aaa gtt gtt gga ttg tct aca ttg cca gaa att tat gaa aag atg   1010
Ile Lys Val Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met
        320                 325                 330
 
gaa aaa gga caa att gtt ggt aga tat gtt gtt gat act tct aaa       1055
Glu Lys Gly Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
    335                 340                 345
 
gaattccgat g                                                      1066

<210> 66
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 66
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 67
<211> 1072
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1058)

<400> 67
gaatactcca tatg atg tct att cca gag act caa aaa gga gtt atc ttt   50
                Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe
                 1               5                   10
 
tat gaa tct cat gga aaa tta gaa tat aaa gac att cca gtt cca aaa   98
Tyr Glu Ser His Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys
         15                  20                  25
 
cct aaa gct aat gaa ttg ttg att aat gtt aaa tat tct gga gtt tgt   146
Pro Lys Ala Asn Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys
     30                  35                  40
 
cat act gat ttg cac gct tgg cat gga gat tgg cct tta cca gtt aaa   194
His Thr Asp Leu His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys
 45                  50                  55                  60
 
ttg cct ttg gtt gga gga cat gaa gga gct gga gtt gtt gtt gga atg   242
Leu Pro Leu Val Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met
                 65                  70                  75
 
gga gaa aat gtt aaa gga tgg aaa att gga gat tat gct gga att aag   290
Gly Glu Asn Val Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys
             80                  85                  90
 
tgg tta aat gga tct tgt atg gct tgt gaa tat tgt gaa ttg gga aat   338
Trp Leu Asn Gly Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn
         95                 100                 105
 
gaa tct aat tgt cca cat gct gat tta tct gga tat act cat gat gga   386
Glu Ser Asn Cys Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly
    110                 115                 120
 
tct ttt caa caa tat gct act gct gat gct gtt caa gcc gct cat atc   434
Ser Phe Gln Gln Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile
125                 130                 135                 140
 
cca caa gga aca gat ttg gct caa gtt gct cca att tta tgt gct gga   482
Pro Gln Gly Thr Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly
                145                 150                 155
 
att act gtt tat aaa gct ctt aaa tct gct aat ttg atg gct gga cat   530
Ile Thr Val Tyr Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His
            160                 165                 170
 
tgg gtt gct att tct ggt gca gct ggt gga ctt gga tca ttg gca gtt   578
Trp Val Ala Ile Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val
        175                 180                 185
 
caa tat gct aaa gct atg gga tat aga gtt ttg gga att gat gga ggt   626
Gln Tyr Ala Lys Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly
    190                 195                 200
 
gaa gga aaa gaa gaa ttg ttt aga tct atc gga gga gag gtt ttt att   674
Glu Gly Lys Glu Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile
205                 210                 215                 220
 
gat ttt act aaa gaa aaa gat ata gtt gga gct gtt tta aaa gca aca   722
Asp Phe Thr Lys Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr
                225                 230                 235
 
gac gga ggt gct cat gga gtt att aat gtt tct gtt tct gag gct gct   770
Asp Gly Gly Ala His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala
            240                 245                 250
 
att gag gct tct act aga tat gtt aga gct aat ggt act act gtt ttg   818
Ile Glu Ala Ser Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu
        255                 260                 265
 
gtt gga atg cca gca gga gca aaa tgt tgt tct gat gtt ttt aat caa   866
Val Gly Met Pro Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln
    270                 275                 280
 
gtt gtt aaa tct att tct atc gtt gga tct tat gtt gga aat aga gct   914
Val Val Lys Ser Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala
285                 290                 295                 300
 
gat act aga gag gct ttg gat ttc ttt gca aga ggt ttg gtt aaa tct   962
Asp Thr Arg Glu Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser
                305                 310                 315
 
cca att aaa gtt gtt gga ttg tct aca ttg cca gaa att tat gaa aag   1010
Pro Ile Lys Val Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys
            320                 325                 330
 
atg gaa aaa gga caa att gtt ggt aga tat gtt gtt gat act tct aaa   1058
Met Glu Lys Gly Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
        335                 340                 345
 
actagtcgat gcct                                                   1072

<210> 68
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 68
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 69
<211> 1044
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1044)

<400> 69
atg tct att cca gaa act cag aaa ggt gtt att ttc tat gaa tct cat   48
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                   10                  15
 
gga aaa ttg gaa tat aaa gac att cca gtt cca aaa cca aaa gct aat   96
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
             20                  25                  30
 
gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt cat act gat ttg   144
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
         35                  40                  45
 
cat gct tgg cat ggt gat tgg cca cta cca gtt aaa ttg cca ttg gtt   192
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
     50                  55                  60
 
ggt ggt cat gaa ggt gct ggt gtt gtt gtt ggt atg ggt gaa aat gtt   240
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
 65                  70                  75                  80
 
aaa ggt tgg aaa ata ggt gat tat gct ggt ata aag tgg tta aat ggt   288
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                 85                  90                  95
 
tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat gaa tct aat tgt   336
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110
 
cca cat gct gat ttg tct ggt tat act cat gat ggt tct ttt caa caa   384
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125
 
tat gct act gct gat gct gtt caa gct gct cat att cca caa ggt aca   432
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140
 
gat ttg gct caa gtt gct cca att ttg tgt gcc gga att act gtt tat   480
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160
 
aaa gca tta aaa tct gct aat ttg atg gct ggt cat tgg gtt gct att   528
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175
 
tct ggt gcg gca ggt ggt cta ggg tca ctg gct gtt caa tat gcc aaa   576
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190
 
gct atg ggt tat aga gtt ttg gga atc gat ggt ggc gaa gga aaa gaa   624
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205
 
gaa ttg ttc aga tct att ggt gga gaa gtt ttc att gat ttc act aaa   672
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220
 
gaa aaa gac att gtt ggt gca gtt tta aaa gct act gat gga ggg gct   720
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240
 
cat ggt gtt att aat gtt tct gtt tct gaa gct gcc ata gaa gct agt   768
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255
 
act aga tat gtt aga gct aat ggt aca act gtt ttg gtc gga atg cca   816
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270
 
gcc ggt gct aaa tgt tgt tct gat gtt ttc aac caa gtt gtt aaa tct   864
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285
 
att tct att gtt ggt tct tat gtt ggt aat aga gct gat act aga gag   912
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300
 
gct ttg gat ttc ttc gct aga ggt ttg gtt aaa tct cct att aaa gtt   960
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320
 
gtt ggg cta tct act tta cca gaa att tat gaa aag atg gaa aaa ggt   1008
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335
 
caa att gtt ggt aga tat gtt gtt gat act tct aaa                   1044
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345
 

<210> 70
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 70
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 71
<211> 1044
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1044)

<400> 71
atg tct att ccg gaa acc cag aaa ggt gtt atc ttt tat gaa tct cat   48
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                   10                  15
 
ggt aaa ttg gaa tat aaa gat atc ccg gtt ccg aaa cct aaa gct aat   96
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
             20                  25                  30
 
gaa ttg ttg att aat gtt aaa tat tct ggt gtt tgt cat acc gat ttg   144
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
         35                  40                  45
 
cat gct tgg cat ggt gat tgg ccg ttg ccg gtt aaa ttg ccg tta gtt   192
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
     50                  55                  60
 
ggt ggt cat gaa ggt gct ggt gtt gtt gtt ggt atg ggt gaa aat gtt   240
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
 65                  70                  75                  80
 
aaa ggt tgg aaa att ggt gat tat gct gga att aaa tgg ttg aat ggt   288
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                 85                  90                  95
 
tct tgt atg gct tgt gaa tat tgt gaa ttg ggt aat gaa tct aat tgt   336
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110
 
ccg cat gct gat ttg tct ggt tat acg cat gat ggt tct ttt cag cag   384
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125
 
tat gcc acc gcc gac gca gtt cag gcc gcg cat att ccg cag ggt acg   432
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140
 
gat ttg gcc cag gtt gct ccg att ttg tgt gcg ggc ata acc gtt tat   480
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160
 
aaa gct ctt aaa tct gcc aac ctt atg gct gga cat tgg gtt gcc att   528
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175
 
tct ggt gcc gct gga ggc ttg gga tct ttg gct gta cag tat gca aaa   576
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190
 
gca atg ggt tat cgt gtt ttg ggc att gat ggt ggt gaa gga aaa gaa   624
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205
 
gaa ttg ttt cgt tct att ggt gga gag gtt ttt att gat ttt acc aaa   672
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220
 
gaa aaa gat atc gtt ggt gcg gtc ttg aaa gcc aca gat gga gga gcc   720
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240
 
cat ggt gtc att aat gtt tct gtt tct gaa gct gcc att gag gct agt   768
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255
 
acg cgt tat gtt cgt gcc aac ggg acc aca gtg ttg gta gga atg cct   816
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270
 
gct ggg gcg aaa tgt tgt tct gat gtg ttt aat cag gtt gtt aaa tct   864
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285
 
atc tct att gtt ggt tct tat gtt ggt aat cgt gct gat aca cgc gag   912
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300
 
gct tta gat ttc ttt gct cgt ggt cta gtt aaa tct ccg att aaa gtt   960
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320
 
gtt ggc ttg agt acc ttg cca gaa att tat gag aaa atg gaa aaa ggt   1008
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335
 
cag att gtt ggt cgt tat gta gtt gat acc tct aaa                   1044
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345
 

<210> 72
<211> 348
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 72
Met Ser Ile Pro Glu Thr Gln Lys Gly Val Ile Phe Tyr Glu Ser His
 1               5                  10                  15      
Gly Lys Leu Glu Tyr Lys Asp Ile Pro Val Pro Lys Pro Lys Ala Asn
            20                  25                  30          
Glu Leu Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu
        35                  40                  45              
His Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val
    50                  55                  60                  
Gly Gly His Glu Gly Ala Gly Val Val Val Gly Met Gly Glu Asn Val
65                  70                  75                  80  
Lys Gly Trp Lys Ile Gly Asp Tyr Ala Gly Ile Lys Trp Leu Asn Gly
                85                  90                  95      
Ser Cys Met Ala Cys Glu Tyr Cys Glu Leu Gly Asn Glu Ser Asn Cys
            100                 105                 110         
Pro His Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln
        115                 120                 125             
Tyr Ala Thr Ala Asp Ala Val Gln Ala Ala His Ile Pro Gln Gly Thr
    130                 135                 140                 
Asp Leu Ala Gln Val Ala Pro Ile Leu Cys Ala Gly Ile Thr Val Tyr
145                 150                 155                 160 
Lys Ala Leu Lys Ser Ala Asn Leu Met Ala Gly His Trp Val Ala Ile
                165                 170                 175     
Ser Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Lys
            180                 185                 190         
Ala Met Gly Tyr Arg Val Leu Gly Ile Asp Gly Gly Glu Gly Lys Glu
        195                 200                 205             
Glu Leu Phe Arg Ser Ile Gly Gly Glu Val Phe Ile Asp Phe Thr Lys
    210                 215                 220                 
Glu Lys Asp Ile Val Gly Ala Val Leu Lys Ala Thr Asp Gly Gly Ala
225                 230                 235                 240 
His Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Glu Ala Ser
                245                 250                 255     
Thr Arg Tyr Val Arg Ala Asn Gly Thr Thr Val Leu Val Gly Met Pro
            260                 265                 270         
Ala Gly Ala Lys Cys Cys Ser Asp Val Phe Asn Gln Val Val Lys Ser
        275                 280                 285             
Ile Ser Ile Val Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu
    290                 295                 300                 
Ala Leu Asp Phe Phe Ala Arg Gly Leu Val Lys Ser Pro Ile Lys Val
305                 310                 315                 320 
Val Gly Leu Ser Thr Leu Pro Glu Ile Tyr Glu Lys Met Glu Lys Gly
                325                 330                 335     
Gln Ile Val Gly Arg Tyr Val Val Asp Thr Ser Lys
            340                 345             


<210> 73
<211> 1128
<212> DNA
<213> S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1128)

<400> 73
atg ttg aga acg tca aca ttg ttc acc aag cgt gtc caa cca agc cta   48
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                   10                  15
 
ttt tct aga aac att ctt aga ttg caa tcc aca gct gca atc cct aag   96
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
             20                  25                  30
 
act caa aaa ggt gtc atc ttt tat gag aat aag ggg aac ctg cat tac   144
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
         35                  40                  45
 
aaa gat atc cct gtc ccc gag cct aag cca aat gaa att tta atc aac   192
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
     50                  55                  60
 
gtt aaa tat tct ggt gta tgt cac acc gat tta cat gct tgg cac ggc   240
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
 65                  70                  75                  80
 
gat tgg cca tta cct gtt aaa cta cca tta gta ggt ggt cat gaa ggt   288
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                 85                  90                  95
 
gct ggt gta gtt gtc aaa cta ggt tcc aat gtc aag ggc tgg aaa gtc   336
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110
 
ggt gat tta gca ggt atc aaa tgg ctg aac ggt tct tgt atg aca tgc   384
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125
 
gaa ttc tgt gaa tca ggt cat gaa tca aat tgt cca gat gct gat tta   432
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140
 
tct ggt tac act cat gat ggt tct ttc caa caa ttt gcg acc gct gat   480
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160
 
gct att caa gcc gcc aaa att caa cag ggt acc gac ttg gcc gaa gta   528
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175
 
gcc cca ata tta tgt gct ggt gtt act gta tat aaa gca cta aaa gag   576
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190
 
gca gac ttg aaa gct ggt gac tgg gtt gcc atc tct ggt gct gca ggt   624
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205
 
ggc ttg ggt tcc ttg gcc gtt caa tat gca act gcg atg ggt tac aga   672
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220
 
gtt cta ggt att gat gca ggt gag gaa aag gaa aaa ctt ttc aag aaa   720
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240
 
ttg ggg ggt gaa gta ttc atc gac ttt act aaa aca aag aat atg gtt   768
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255
 
tct gac att caa gaa gct acc aaa ggt ggc cct cat ggt gtc att aac   816
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270
 
gtt tcc gtt tct gaa gcc gct att tct cta tct acg gaa tat gtt aga   864
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285
 
cca tgt ggt acc gtc gtt ttg gtt ggt ttg ccc gct aac gcc tac gtt   912
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300
 
aaa tca gag gta ttc tct cat gtg gtg aag tcc atc aat atc aag ggt   960
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320
 
tct tat gtt ggt aac aga gct gat acg aga gaa gcc tta gac ttc ttt   1008
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335
 
agc aga ggt ttg atc aaa tca cca atc aaa att gtt gga tta tct gaa   1056
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350
 
tta cca aag gtt tat gac ttg atg gaa aag ggc aag att ttg ggt aga   1104
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365
 
tac gtc gtc gat act agt aaa taa                                   1128
Tyr Val Val Asp Thr Ser Lys  *
    370                 375
 

<210> 74
<211> 375
<212> PRT
<213> S. cerevisiae

<400> 74
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 75
<211> 1125
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1125)

<400> 75
atg ttg aga act tct aca ttg ttt act aaa aga gtt caa cca tct ttg   48
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                   10                  15
 
ttt tct aga aat ata ttg agg ttg caa tct aca gct gct att cca aaa   96
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
             20                  25                  30
 
act caa aaa ggt gta att ttc tat gaa aat aaa ggt aat ttg cat tat   144
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
         35                  40                  45
 
aaa gac att cca gtt cca gaa cca aaa cca aat gaa att ttg att aat   192
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
     50                  55                  60
 
gtt aaa tat tct gga gtt tgt cat act gat ttg cac gct tgg cat ggt   240
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
 65                  70                  75                  80
 
gat tgg cct tta cca gtt aaa ttg cca ttg gtt ggt ggt cat gaa ggt   288
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                 85                  90                  95
 
gct ggt gtt gtt gtt aaa ttg ggt tct aat gtt aaa ggt tgg aaa gta   336
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110
 
ggt gat ttg gct gga att aaa tgg tta aat ggt tct tgt atg act tgt   384
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125
 
gaa ttt tgt gag tct ggt cac gaa tct aat tgt cca gat gca gat ttg   432
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140
 
tca ggt tat act cat gat ggt tct ttt caa caa ttt gca act gct gat   480
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160
 
gct ata caa gct gct aaa ata caa caa ggt act gat ttg gct gaa gtt   528
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175
 
gct cca att ttg tgt gca ggt gtt act gtt tat aaa gct cta aag gaa   576
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190
 
gct gat tta aaa gca gga gat tgg gtt gct att tct gga gca gct ggc   624
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205
 
ggt cta ggt tct ttg gct gtt caa tat gca act gct atg ggt tat aga   672
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220
 
gtt ttg gga att gat gct ggt gaa gaa aaa gaa aaa ttg ttt aaa aag   720
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240
 
ttg ggt ggt gaa gtt ttt att gat ttt act aaa act aaa aat atg gtt   768
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255
 
tca gat ata caa gaa gct aca aaa ggt ggt cca cac ggt gta att aat   816
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270
 
gtt tca gtt tca gaa gct gct att tct ttg tca act gaa tat gtt aga   864
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285
 
cca tgt ggt act gtt gtt ttg gta ggt ttg cca gct aat gct tat gtt   912
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300
 
aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att aac att aaa ggt   960
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320
 
tct tat gtt ggt aat aga gct gat act aga gaa gca ttg gat ttc ttt   1008
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335
 
tct aga ggc ttg att aaa tct cct att aaa att gtt ggt ttg tct gaa   1056
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350
 
ttg cca aaa gta tat gat ttg atg gaa aaa ggt aaa att ttg ggt aga   1104
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365
 
tat gtt gtt gat act tct aaa                                       1125
Tyr Val Val Asp Thr Ser Lys
    370                 375
 

<210> 76
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 76
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 77
<211> 1147
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (12)...(1136)

<400> 77
tactcaagct t atg ttg aga act tct aca ttg ttt act aaa aga gtt caa  50
             Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln
              1               5                   10
 
cca tct ttg ttt tct aga aat ata ttg agg ttg caa tct aca gct gct   98
Pro Ser Leu Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala
     15                  20                  25
 
att cca aaa act caa aaa ggt gta att ttc tat gaa aat aaa ggt aat   146
Ile Pro Lys Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn
 30                  35                  40                  45
 
ttg cat tat aaa gac att cca gtt cca gaa cca aaa cca aat gaa att   194
Leu His Tyr Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile
                 50                  55                  60
 
ttg att aat gtt aaa tat tct gga gtt tgt cat act gat ttg cac gct   242
Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala
             65                  70                  75
 
tgg cat ggt gat tgg cct tta cca gtt aaa ttg cca ttg gtt ggt ggt   290
Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly
         80                  85                  90
 
cat gaa ggt gct ggt gtt gtt gtt aaa ttg ggt tct aat gtt aaa ggt   338
His Glu Gly Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly
     95                 100                 105
 
tgg aaa gta ggt gat ttg gct gga att aaa tgg tta aat ggt tct tgt   386
Trp Lys Val Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys
110                 115                 120                 125
 
atg act tgt gaa ttt tgt gag tct ggt cac gaa tct aat tgt cca gat   434
Met Thr Cys Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp
                130                 135                 140
 
gca gat ttg tca ggt tat act cat gat ggt tct ttt caa caa ttt gca   482
Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala
            145                 150                 155
 
act gct gat gct ata caa gct gct aaa ata caa caa ggt act gat ttg   530
Thr Ala Asp Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu
        160                 165                 170
 
gct gaa gtt gct cca att ttg tgt gca ggt gtt act gtt tat aaa gct   578
Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala
    175                 180                 185
 
cta aag gaa gct gat tta aaa gca gga gat tgg gtt gct att tct gga   626
Leu Lys Glu Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly
190                 195                 200                 205
 
gca gct ggc ggt cta ggt tct ttg gct gtt caa tat gca act gct atg   674
Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met
                210                 215                 220
 
ggt tat aga gtt ttg gga att gat gct ggt gaa gaa aaa gaa aaa ttg   722
Gly Tyr Arg Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu
            225                 230                 235
 
ttt aaa aag ttg ggt ggt gaa gtt ttt att gat ttt act aaa act aaa   770
Phe Lys Lys Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys
        240                 245                 250
 
aat atg gtt tca gat ata caa gaa gct aca aaa ggt ggt cca cac ggt   818
Asn Met Val Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly
    255                 260                 265
 
gta att aat gtt tca gtt tca gaa gct gct att tct ttg tca act gaa   866
Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu
270                 275                 280                 285
 
tat gtt aga cca tgt ggt act gtt gtt ttg gta ggt ttg cca gct aat   914
Tyr Val Arg Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn
                290                 295                 300
 
gct tat gtt aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att aac   962
Ala Tyr Val Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn
            305                 310                 315
 
att aaa ggt tct tat gtt ggt aat aga gct gat act aga gaa gca ttg   1010
Ile Lys Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu
        320                 325                 330
 
gat ttc ttt tct aga ggc ttg att aaa tct cct att aaa att gtt ggt   1058
Asp Phe Phe Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly
    335                 340                 345
 
ttg tct gaa ttg cca aaa gta tat gat ttg atg gaa aaa ggt aaa att   1106
Leu Ser Glu Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile
350                 355                 360                 365
 
ttg ggt aga tat gtt gtt gat act tct aaa gaattccgat g              1147
Leu Gly Arg Tyr Val Val Asp Thr Ser Lys
                370                 375
 

<210> 78
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 78
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 79
<211> 1153
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (15)...(1139)

<400> 79
gaatactcca tatg atg ttg aga act tct aca ttg ttt act aaa aga gtt   50
                Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val
                 1               5                   10
 
caa cca tct ttg ttt tct aga aat ata ttg agg ttg caa tct aca gct   98
Gln Pro Ser Leu Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala
         15                  20                  25
 
gct att cca aaa act caa aaa ggt gta att ttc tat gaa aat aaa ggt   146
Ala Ile Pro Lys Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly
     30                  35                  40
 
aat ttg cat tat aaa gac att cca gtt cca gaa cca aaa cca aat gaa   194
Asn Leu His Tyr Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu
 45                  50                  55                  60
 
att ttg att aat gtt aaa tat tct gga gtt tgt cat act gat ttg cac   242
Ile Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His
                 65                  70                  75
 
gct tgg cat ggt gat tgg cct tta cca gtt aaa ttg cca ttg gtt ggt   290
Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly
             80                  85                  90
 
ggt cat gaa ggt gct ggt gtt gtt gtt aaa ttg ggt tct aat gtt aaa   338
Gly His Glu Gly Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys
         95                 100                 105
 
ggt tgg aaa gta ggt gat ttg gct gga att aaa tgg tta aat ggt tct   386
Gly Trp Lys Val Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser
    110                 115                 120
 
tgt atg act tgt gaa ttt tgt gag tct ggt cac gaa tct aat tgt cca   434
Cys Met Thr Cys Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro
125                 130                 135                 140
 
gat gca gat ttg tca ggt tat act cat gat ggt tct ttt caa caa ttt   482
Asp Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe
                145                 150                 155
 
gca act gct gat gct ata caa gct gct aaa ata caa caa ggt act gat   530
Ala Thr Ala Asp Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp
            160                 165                 170
 
ttg gct gaa gtt gct cca att ttg tgt gca ggt gtt act gtt tat aaa   578
Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys
        175                 180                 185
 
gct cta aag gaa gct gat tta aaa gca gga gat tgg gtt gct att tct   626
Ala Leu Lys Glu Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser
    190                 195                 200
 
gga gca gct ggc ggt cta ggt tct ttg gct gtt caa tat gca act gct   674
Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala
205                 210                 215                 220
 
atg ggt tat aga gtt ttg gga att gat gct ggt gaa gaa aaa gaa aaa   722
Met Gly Tyr Arg Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys
                225                 230                 235
 
ttg ttt aaa aag ttg ggt ggt gaa gtt ttt att gat ttt act aaa act   770
Leu Phe Lys Lys Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr
            240                 245                 250
 
aaa aat atg gtt tca gat ata caa gaa gct aca aaa ggt ggt cca cac   818
Lys Asn Met Val Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His
        255                 260                 265
 
ggt gta att aat gtt tca gtt tca gaa gct gct att tct ttg tca act   866
Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr
    270                 275                 280
 
gaa tat gtt aga cca tgt ggt act gtt gtt ttg gta ggt ttg cca gct   914
Glu Tyr Val Arg Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala
285                 290                 295                 300
 
aat gct tat gtt aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att   962
Asn Ala Tyr Val Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile
                305                 310                 315
 
aac att aaa ggt tct tat gtt ggt aat aga gct gat act aga gaa gca   1010
Asn Ile Lys Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala
            320                 325                 330
 
ttg gat ttc ttt tct aga ggc ttg att aaa tct cct att aaa att gtt   1058
Leu Asp Phe Phe Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val
        335                 340                 345
 
ggt ttg tct gaa ttg cca aaa gta tat gat ttg atg gaa aaa ggt aaa   1106
Gly Leu Ser Glu Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys
    350                 355                 360
 
att ttg ggt aga tat gtt gtt gat act tct aaa actagtcgat gcct       1153
Ile Leu Gly Arg Tyr Val Val Asp Thr Ser Lys
365                 370                 375
 

<210> 80
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 80
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 81
<211> 1125
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1125)

<400> 81
atg ttg aga act tct aca ttg ttt act aaa aga gtt caa cca tct ttg   48
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                   10                  15
 
ttt tct aga aat ata ttg agg ttg caa tct aca gct gct att cca aaa   96
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
             20                  25                  30
 
act caa aaa ggt gta att ttc tat gaa aat aaa ggt aat ttg cat tat   144
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
         35                  40                  45
 
aaa gac att cca gtt cca gaa cca aaa cca aat gaa att ttg att aat   192
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
     50                  55                  60
 
gtt aaa tat tct gga gtt tgt cat act gat ttg cac gct tgg cat ggt   240
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
 65                  70                  75                  80
 
gat tgg cct tta cca gtt aaa ttg cca ttg gtt ggt ggt cat gaa ggt   288
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                 85                  90                  95
 
gct ggt gtt gtt gtt aaa ttg ggt tct aat gtt aaa ggt tgg aaa gta   336
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110
 
ggt gat ttg gct gga att aaa tgg tta aat ggt tct tgt atg act tgt   384
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125
 
gaa ttt tgt gag tct ggt cac gaa tct aat tgt cca gat gca gat ttg   432
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140
 
tca ggt tat act cat gat ggt tct ttt caa caa ttt gca act gct gat   480
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160
 
gct ata caa gct gct aaa ata caa caa ggt act gat ttg gct gaa gtt   528
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175
 
gct cca att ttg tgt gca ggt gtt act gtt tat aaa gct cta aag gaa   576
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190
 
gct gat tta aaa gca gga gat tgg gtt gct att tct gga gca gct ggc   624
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205
 
ggt cta ggt tct ttg gct gtt caa tat gca act gct atg ggt tat aga   672
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220
 
gtt ttg gga att gat gct ggt gaa gaa aaa gaa aaa ttg ttt aaa aag   720
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240
 
ttg ggt ggt gaa gtt ttt att gat ttt act aaa act aaa aat atg gtt   768
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255
 
tca gat ata caa gaa gct aca aaa ggt ggt cca cac ggt gta att aat   816
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270
 
gtt tca gtt tca gaa gct gct att tct ttg tca act gaa tat gtt aga   864
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285
 
cca tgt ggt act gtt gtt ttg gta ggt ttg cca gct aat gct tat gtt   912
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300
 
aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att aac att aaa ggt   960
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320
 
tct tat gtt ggt aat aga gct gat act aga gaa gca ttg gat ttc ttt   1008
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335
 
tct aga ggc ttg att aaa tct cct att aaa att gtt ggt ttg tct gaa   1056
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350
 
ttg cca aaa gta tat gat ttg atg gaa aaa ggt aaa att ttg ggt aga   1104
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365
 
tat gtt gtt gat act tct aaa                                       1125
Tyr Val Val Asp Thr Ser Lys
    370                 375
 

<210> 82
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 82
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 83
<211> 1147
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (12)...(1136)

<400> 83
tactcaagct t atg ttg aga act tct aca ttg ttt act aaa aga gtt caa  50
             Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln
              1               5                   10
 
cca tct ttg ttt tct aga aat ata ttg agg ttg caa tct aca gct gct   98
Pro Ser Leu Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala
     15                  20                  25
 
att cca aaa act caa aaa ggt gta att ttc tat gaa aat aaa ggt aat   146
Ile Pro Lys Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn
 30                  35                  40                  45
 
ttg cat tat aaa gac att cca gtt cca gaa cca aaa cca aat gaa att   194
Leu His Tyr Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile
                 50                  55                  60
 
ttg att aat gtt aaa tat tct gga gtt tgt cat act gat ttg cac gct   242
Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala
             65                  70                  75
 
tgg cat ggt gat tgg cct tta cca gtt aaa ttg cca ttg gtt ggt ggt   290
Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly
         80                  85                  90
 
cat gaa ggt gct ggt gtt gtt gtt aaa ttg ggt tct aat gtt aaa ggt   338
His Glu Gly Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly
     95                 100                 105
 
tgg aaa gta ggt gat ttg gct gga att aaa tgg tta aat ggt tct tgt   386
Trp Lys Val Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys
110                 115                 120                 125
 
atg act tgt gaa ttt tgt gag tct ggt cac gaa tct aat tgt cca gat   434
Met Thr Cys Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp
                130                 135                 140
 
gca gat ttg tca ggt tat act cat gat ggt tct ttt caa caa ttt gca   482
Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala
            145                 150                 155
 
act gct gat gct ata caa gct gct aaa ata caa caa ggt act gat ttg   530
Thr Ala Asp Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu
        160                 165                 170
 
gct gaa gtt gct cca att ttg tgt gca ggt gtt act gtt tat aaa gct   578
Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala
    175                 180                 185
 
cta aag gaa gct gat tta aaa gca gga gat tgg gtt gct att tct gga   626
Leu Lys Glu Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly
190                 195                 200                 205
 
gca gct ggc ggt cta ggt tct ttg gct gtt caa tat gca act gct atg   674
Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met
                210                 215                 220
 
ggt tat aga gtt ttg gga att gat gct ggt gaa gaa aaa gaa aaa ttg   722
Gly Tyr Arg Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu
            225                 230                 235
 
ttt aaa aag ttg ggt ggt gaa gtt ttt att gat ttt act aaa act aaa   770
Phe Lys Lys Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys
        240                 245                 250
 
aat atg gtt tca gat ata caa gaa gct aca aaa ggt ggt cca cac ggt   818
Asn Met Val Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly
    255                 260                 265
 
gta att aat gtt tca gtt tca gaa gct gct att tct ttg tca act gaa   866
Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu
270                 275                 280                 285
 
tat gtt aga cca tgt ggt act gtt gtt ttg gta ggt ttg cca gct aat   914
Tyr Val Arg Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn
                290                 295                 300
 
gct tat gtt aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att aac   962
Ala Tyr Val Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn
            305                 310                 315
 
att aaa ggt tct tat gtt ggt aat aga gct gat act aga gaa gca ttg   1010
Ile Lys Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu
        320                 325                 330
 
gat ttc ttt tct aga ggc ttg att aaa tct cct att aaa att gtt ggt   1058
Asp Phe Phe Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly
    335                 340                 345
 
ttg tct gaa ttg cca aaa gta tat gat ttg atg gaa aaa ggt aaa att   1106
Leu Ser Glu Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile
350                 355                 360                 365
 
ttg ggt aga tat gtt gtt gat act tct aaa gaattccgat g              1147
Leu Gly Arg Tyr Val Val Asp Thr Ser Lys
                370                 375
 

<210> 84
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 84
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 85
<211> 1153
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (15)...(1139)

<400> 85
gaatactcca tatg atg ttg aga act tct aca ttg ttt act aaa aga gtt   50
                Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val
                 1               5                   10
 
caa cca tct ttg ttt tct aga aat ata ttg agg ttg caa tct aca gct   98
Gln Pro Ser Leu Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala
         15                  20                  25
 
gct att cca aaa act caa aaa ggt gta att ttc tat gaa aat aaa ggt   146
Ala Ile Pro Lys Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly
     30                  35                  40
 
aat ttg cat tat aaa gac att cca gtt cca gaa cca aaa cca aat gaa   194
Asn Leu His Tyr Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu
 45                  50                  55                  60
 
att ttg att aat gtt aaa tat tct gga gtt tgt cat act gat ttg cac   242
Ile Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His
                 65                  70                  75
 
gct tgg cat ggt gat tgg cct tta cca gtt aaa ttg cca ttg gtt ggt   290
Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly
             80                  85                  90
 
ggt cat gaa ggt gct ggt gtt gtt gtt aaa ttg ggt tct aat gtt aaa   338
Gly His Glu Gly Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys
         95                 100                 105
 
ggt tgg aaa gta ggt gat ttg gct gga att aaa tgg tta aat ggt tct   386
Gly Trp Lys Val Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser
    110                 115                 120
 
tgt atg act tgt gaa ttt tgt gag tct ggt cac gaa tct aat tgt cca   434
Cys Met Thr Cys Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro
125                 130                 135                 140
 
gat gca gat ttg tca ggt tat act cat gat ggt tct ttt caa caa ttt   482
Asp Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe
                145                 150                 155
 
gca act gct gat gct ata caa gct gct aaa ata caa caa ggt act gat   530
Ala Thr Ala Asp Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp
            160                 165                 170
 
ttg gct gaa gtt gct cca att ttg tgt gca ggt gtt act gtt tat aaa   578
Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys
        175                 180                 185
 
gct cta aag gaa gct gat tta aaa gca gga gat tgg gtt gct att tct   626
Ala Leu Lys Glu Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser
    190                 195                 200
 
gga gca gct ggc ggt cta ggt tct ttg gct gtt caa tat gca act gct   674
Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala
205                 210                 215                 220
 
atg ggt tat aga gtt ttg gga att gat gct ggt gaa gaa aaa gaa aaa   722
Met Gly Tyr Arg Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys
                225                 230                 235
 
ttg ttt aaa aag ttg ggt ggt gaa gtt ttt att gat ttt act aaa act   770
Leu Phe Lys Lys Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr
            240                 245                 250
 
aaa aat atg gtt tca gat ata caa gaa gct aca aaa ggt ggt cca cac   818
Lys Asn Met Val Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His
        255                 260                 265
 
ggt gta att aat gtt tca gtt tca gaa gct gct att tct ttg tca act   866
Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr
    270                 275                 280
 
gaa tat gtt aga cca tgt ggt act gtt gtt ttg gta ggt ttg cca gct   914
Glu Tyr Val Arg Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala
285                 290                 295                 300
 
aat gct tat gtt aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att   962
Asn Ala Tyr Val Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile
                305                 310                 315
 
aac att aaa ggt tct tat gtt ggt aat aga gct gat act aga gaa gca   1010
Asn Ile Lys Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala
            320                 325                 330
 
ttg gat ttc ttt tct aga ggc ttg att aaa tct cct att aaa att gtt   1058
Leu Asp Phe Phe Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val
        335                 340                 345
 
ggt ttg tct gaa ttg cca aaa gta tat gat ttg atg gaa aaa ggt aaa   1106
Gly Leu Ser Glu Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys
    350                 355                 360
 
att ttg ggt aga tat gtt gtt gat act tct aaa actagtcgat gcct       1153
Ile Leu Gly Arg Tyr Val Val Asp Thr Ser Lys
365                 370                 375
 

<210> 86
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 86
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 87
<211> 1125
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1125)

<400> 87
atg ttg aga act tct act tta ttt act aaa aga gtt caa cca tca ttg   48
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                   10                  15
 
ttt tct aga aac att ttg agg ttg caa tct act gct gct att cca aaa   96
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
             20                  25                  30
 
act caa aaa gga gtg att ttc tat gaa aat aaa gga aat ttg cat tat   144
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
         35                  40                  45
 
aaa gac att cca gtt cca gaa cca aaa cct aat gaa att ttg att aat   192
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
     50                  55                  60
 
gtt aaa tat tct gga gtt tgt cat act gat ttg cac gct tgg cat gga   240
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
 65                  70                  75                  80
 
gat tgg cct tta cca gtt aaa tta cca ttg gtt gga gga cat gaa gga   288
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                 85                  90                  95
 
gct ggt gtt gtt gtt aaa ttg gga tct aat gtt aaa gga tgg aaa gtt   336
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110
 
gga gat ttg gct gga att aag tgg tta aat gga tct tgt atg act tgt   384
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125
 
gaa ttt tgt gaa tct ggt cat gaa tct aat tgt cca gac gct gat ttg   432
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140
 
agt gga tat aca cat gat gga tct ttt caa caa ttc gct act gct gat   480
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160
 
gct att caa gct gct aaa att caa caa gga aca gat ttg gct gaa gtt   528
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175
 
gct cca att ttg tgt gct ggt gtt act gtt tat aaa gct ctt aag gaa   576
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190
 
gca gat tta aaa gct gga gat tgg gtt gct att tca gga gct gcc ggt   624
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205
 
gga tta gga tca ttg gct gtt caa tat gct act gct atg gga tat aga   672
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220
 
gtt ttg gga att gat gca gga gaa gaa aaa gaa aaa ttg ttt aaa aag   720
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240
 
ttg gga gga gaa gtt ttt att gat ttt act aaa act aaa aat atg gtt   768
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255
 
tct gac att caa gaa gct act aaa ggt gga cca cac gga gtt att aat   816
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270
 
gtt tct gtt tct gaa gct gct att tct tta tct act gaa tat gtt aga   864
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285
 
cca tgt ggt act gtt gtt ttg gtt gga tta cca gct aac gct tat gtt   912
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300
 
aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att aac att aaa gga   960
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320
 
tct tat gtt gga aat aga gct gat act aga gag gct ttg gat ttc ttt   1008
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335
 
tct aga gga ttg att aaa tct cca att aaa att gtt gga ttg tct gaa   1056
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350
 
ttg cca aaa gtt tat gat ttg atg gaa aaa gga aaa att ttg ggt aga   1104
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365
 
tat gtt gtt gat act tct aaa                                       1125
Tyr Val Val Asp Thr Ser Lys
    370                 375
 

<210> 88
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 88
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 89
<211> 1147
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (12)...(1136)

<400> 89
tactcaagct t atg ttg aga act tct act tta ttt act aaa aga gtt caa  50
             Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln
              1               5                   10
 
cca tca ttg ttt tct aga aac att ttg agg ttg caa tct act gct gct   98
Pro Ser Leu Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala
     15                  20                  25
 
att cca aaa act caa aaa gga gtg att ttc tat gaa aat aaa gga aat   146
Ile Pro Lys Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn
 30                  35                  40                  45
 
ttg cat tat aaa gac att cca gtt cca gaa cca aaa cct aat gaa att   194
Leu His Tyr Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile
                 50                  55                  60
 
ttg att aat gtt aaa tat tct gga gtt tgt cat act gat ttg cac gct   242
Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala
             65                  70                  75
 
tgg cat gga gat tgg cct tta cca gtt aaa tta cca ttg gtt gga gga   290
Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly
         80                  85                  90
 
cat gaa gga gct ggt gtt gtt gtt aaa ttg gga tct aat gtt aaa gga   338
His Glu Gly Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly
     95                 100                 105
 
tgg aaa gtt gga gat ttg gct gga att aag tgg tta aat gga tct tgt   386
Trp Lys Val Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys
110                 115                 120                 125
 
atg act tgt gaa ttt tgt gaa tct ggt cat gaa tct aat tgt cca gac   434
Met Thr Cys Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp
                130                 135                 140
 
gct gat ttg agt gga tat aca cat gat gga tct ttt caa caa ttc gct   482
Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala
            145                 150                 155
 
act gct gat gct att caa gct gct aaa att caa caa gga aca gat ttg   530
Thr Ala Asp Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu
        160                 165                 170
 
gct gaa gtt gct cca att ttg tgt gct ggt gtt act gtt tat aaa gct   578
Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala
    175                 180                 185
 
ctt aag gaa gca gat tta aaa gct gga gat tgg gtt gct att tca gga   626
Leu Lys Glu Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly
190                 195                 200                 205
 
gct gcc ggt gga tta gga tca ttg gct gtt caa tat gct act gct atg   674
Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met
                210                 215                 220
 
gga tat aga gtt ttg gga att gat gca gga gaa gaa aaa gaa aaa ttg   722
Gly Tyr Arg Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu
            225                 230                 235
 
ttt aaa aag ttg gga gga gaa gtt ttt att gat ttt act aaa act aaa   770
Phe Lys Lys Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys
        240                 245                 250
 
aat atg gtt tct gac att caa gaa gct act aaa ggt gga cca cac gga   818
Asn Met Val Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly
    255                 260                 265
 
gtt att aat gtt tct gtt tct gaa gct gct att tct tta tct act gaa   866
Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu
270                 275                 280                 285
 
tat gtt aga cca tgt ggt act gtt gtt ttg gtt gga tta cca gct aac   914
Tyr Val Arg Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn
                290                 295                 300
 
gct tat gtt aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att aac   962
Ala Tyr Val Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn
            305                 310                 315
 
att aaa gga tct tat gtt gga aat aga gct gat act aga gag gct ttg   1010
Ile Lys Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu
        320                 325                 330
 
gat ttc ttt tct aga gga ttg att aaa tct cca att aaa att gtt gga   1058
Asp Phe Phe Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly
    335                 340                 345
 
ttg tct gaa ttg cca aaa gtt tat gat ttg atg gaa aaa gga aaa att   1106
Leu Ser Glu Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile
350                 355                 360                 365
 
ttg ggt aga tat gtt gtt gat act tct aaa gaattccgat g              1147
Leu Gly Arg Tyr Val Val Asp Thr Ser Lys
                370                 375
 

<210> 90
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 90
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 91
<211> 1153
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (15)...(1139)

<400> 91
gaatactcca tatg atg ttg aga act tct act tta ttt act aaa aga gtt   50
                Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val
                 1               5                   10
 
caa cca tca ttg ttt tct aga aac att ttg agg ttg caa tct act gct   98
Gln Pro Ser Leu Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala
         15                  20                  25
 
gct att cca aaa act caa aaa gga gtg att ttc tat gaa aat aaa gga   146
Ala Ile Pro Lys Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly
     30                  35                  40
 
aat ttg cat tat aaa gac att cca gtt cca gaa cca aaa cct aat gaa   194
Asn Leu His Tyr Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu
 45                  50                  55                  60
 
att ttg att aat gtt aaa tat tct gga gtt tgt cat act gat ttg cac   242
Ile Leu Ile Asn Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His
                 65                  70                  75
 
gct tgg cat gga gat tgg cct tta cca gtt aaa tta cca ttg gtt gga   290
Ala Trp His Gly Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly
             80                  85                  90
 
gga cat gaa gga gct ggt gtt gtt gtt aaa ttg gga tct aat gtt aaa   338
Gly His Glu Gly Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys
         95                 100                 105
 
gga tgg aaa gtt gga gat ttg gct gga att aag tgg tta aat gga tct   386
Gly Trp Lys Val Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser
    110                 115                 120
 
tgt atg act tgt gaa ttt tgt gaa tct ggt cat gaa tct aat tgt cca   434
Cys Met Thr Cys Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro
125                 130                 135                 140
 
gac gct gat ttg agt gga tat aca cat gat gga tct ttt caa caa ttc   482
Asp Ala Asp Leu Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe
                145                 150                 155
 
gct act gct gat gct att caa gct gct aaa att caa caa gga aca gat   530
Ala Thr Ala Asp Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp
            160                 165                 170
 
ttg gct gaa gtt gct cca att ttg tgt gct ggt gtt act gtt tat aaa   578
Leu Ala Glu Val Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys
        175                 180                 185
 
gct ctt aag gaa gca gat tta aaa gct gga gat tgg gtt gct att tca   626
Ala Leu Lys Glu Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser
    190                 195                 200
 
gga gct gcc ggt gga tta gga tca ttg gct gtt caa tat gct act gct   674
Gly Ala Ala Gly Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala
205                 210                 215                 220
 
atg gga tat aga gtt ttg gga att gat gca gga gaa gaa aaa gaa aaa   722
Met Gly Tyr Arg Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys
                225                 230                 235
 
ttg ttt aaa aag ttg gga gga gaa gtt ttt att gat ttt act aaa act   770
Leu Phe Lys Lys Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr
            240                 245                 250
 
aaa aat atg gtt tct gac att caa gaa gct act aaa ggt gga cca cac   818
Lys Asn Met Val Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His
        255                 260                 265
 
gga gtt att aat gtt tct gtt tct gaa gct gct att tct tta tct act   866
Gly Val Ile Asn Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr
    270                 275                 280
 
gaa tat gtt aga cca tgt ggt act gtt gtt ttg gtt gga tta cca gct   914
Glu Tyr Val Arg Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala
285                 290                 295                 300
 
aac gct tat gtt aaa tct gaa gtt ttt agt cat gtt gtt aaa tct att   962
Asn Ala Tyr Val Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile
                305                 310                 315
 
aac att aaa gga tct tat gtt gga aat aga gct gat act aga gag gct   1010
Asn Ile Lys Gly Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala
            320                 325                 330
 
ttg gat ttc ttt tct aga gga ttg att aaa tct cca att aaa att gtt   1058
Leu Asp Phe Phe Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val
        335                 340                 345
 
gga ttg tct gaa ttg cca aaa gtt tat gat ttg atg gaa aaa gga aaa   1106
Gly Leu Ser Glu Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys
    350                 355                 360
 
att ttg ggt aga tat gtt gtt gat act tct aaa actagtcgat gcct       1153
Ile Leu Gly Arg Tyr Val Val Asp Thr Ser Lys
365                 370                 375
 

<210> 92
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 92
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 93
<211> 1125
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1125)

<400> 93
atg ttg aga act tct act tta ttc act aaa aga gtt caa cca tct tta   48
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                   10                  15
 
ttc tct agg aat att ttg aga ttg cag agt act gct gct att cca aaa   96
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
             20                  25                  30
 
act caa aaa ggt gtt att ttc tat gaa aat aaa ggt aat ttg cat tat   144
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
         35                  40                  45
 
aaa gac att cca gtt cca gaa cca aaa cca aat gaa att ttg att aat   192
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
     50                  55                  60
 
gtt aaa tat tct ggt gtt tgt cat act gat ttg cat gct tgg cat ggt   240
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
 65                  70                  75                  80
 
gat tgg cca ttg ccg gtt aaa ttg cca ttg gtt ggt ggt cat gaa ggt   288
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                 85                  90                  95
 
gct ggt gta gtt gtt aaa ttg ggt tct aat gtt aaa ggt tgg aaa gtt   336
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110
 
ggt gat ttg gct gga att aag tgg tta aat ggt tct tgt atg act tgt   384
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125
 
gag ttc tgt gaa tct ggt cat gag tct aat tgt cca gat gct gat ttg   432
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140
 
agc ggt tat act cat gat ggt tct ttt caa caa ttc gct act gct gat   480
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160
 
gct atc caa gct gct aaa atc caa caa gga act gat tta gcc gaa gtt   528
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175
 
gct cca att ttg tgt gcg gga gtc act gtt tat aag gct tta aaa gaa   576
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190
 
gct gat tta aaa gct gga gat tgg gtt gct att tct ggt gca gct gga   624
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205
 
ggt tta gga agt ttg gca gtt caa tat gct acg gct atg ggt tat aga   672
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220
 
gtt ttg gga att gat gct ggg gaa gaa aaa gaa aaa ttg ttc aaa aag   720
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240
 
ttg ggt ggg gag gta ttc att gat ttc act aaa act aaa aat atg gtt   768
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255
 
tct gac atc cag gaa gct act aaa ggt ggt cca cat ggt gtt att aat   816
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270
 
gtt tct gtt tct gaa gcg gcc atc tca ttg tct act gaa tat gtt aga   864
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285
 
ccg tgt ggc act gtt gtt tta gta ggg ctt cca gct aat gct tat gtt   912
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300
 
aaa tct gaa gtt ttc tct cat gtt gtt aaa tct att aat att aaa ggt   960
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320
 
tct tat gtc ggg aat aga gct gat act aga gaa gct ctt gat ttc ttc   1008
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335
 
agt aga ggt ttg att aaa tct cct att aaa att gtt ggt ttg tct gaa   1056
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350
 
ttg cca aaa gtt tat gat ttg atg gaa aaa ggt aag att ttg ggt aga   1104
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365
 
tat gtt gtt gat act tct aaa                                       1125
Tyr Val Val Asp Thr Ser Lys
    370                 375
 

<210> 94
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 94
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 95
<211> 1125
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1125)

<400> 95
atg ttg cgt acc tct acc ttg ttt acc aaa cgt gtt cag ccg tct ttg   48
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                   10                  15
 
ttt tct cgt aat att ttg cgt ttg cag tct acc gcc gcc att ccg aaa   96
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
             20                  25                  30
 
acc cag aaa ggt gtc att ttc tat gag aat aaa ggt aat ttg cat tat   144
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
         35                  40                  45
 
aaa gat atc ccg gtt ccg gag ccc aaa ccg aat gaa att ttg att aat   192
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
     50                  55                  60
 
gtt aaa tat tct ggt gtt tgt cat acc gat ttg cat gct tgg cat ggt   240
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
 65                  70                  75                  80
 
gat tgg ccg ttg ccg gtt aaa ttg ccg tta gtt ggt ggt cat gaa ggt   288
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                 85                  90                  95
 
gcg gga gtt gtt gtt aaa ttg ggt tct aat gtt aaa ggt tgg aaa gtt   336
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110
 
ggt gat ttg gct gga atc aaa tgg ttg aat ggt tct tgt atg acc tgt   384
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125
 
gaa ttt tgt gaa tct ggt cat gag tct aat tgt ccg gat gct gat ttg   432
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140
 
agt ggt tat acg cat gat ggt tct ttt cag cag ttt gcc aca gca gac   480
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160
 
gca ata cag gcc gct aaa att cag cag ggc act gat tta gct gaa gtt   528
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175
 
gcc cct att ttg tgt gct ggg gtg acc gtt tat aaa gcc ctt aaa gaa   576
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190
 
gct gat tta aaa gct ggt gac tgg gtc gct atc tct ggt gct gca gga   624
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205
 
ggt tta gga agt ttg gct gtc cag tat gct act gcc atg ggt tat cgt   672
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220
 
gtt ttg ggc att gat gct ggc gaa gaa aaa gaa aaa ttg ttt aaa aag   720
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240
 
ttg ggt gga gag gtt ttt att gat ttt acc aaa acc aaa aat atg gtt   768
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255
 
tct gac att cag gaa gcg aca aaa ggt ggt ccg cat ggc gta atc aac   816
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270
 
gtt tct gtt tct gag gct gct atc tct ttg tct act gaa tat gtt cgt   864
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285
 
ccg tgt ggt aca gtt gtt ttg gtt ggc ttg ccc gct aac gct tat gtt   912
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300
 
aaa tct gaa gtc ttt tca cat gtt gtt aaa tct att aat att aaa ggt   960
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320
 
tct tat gtg gga aat cga gct gac aca cgt gaa gct ctt gac ttt ttc   1008
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335
 
tct cgt ggt ttg att aaa tct ccg att aaa att gtt ggt ttg tct gaa   1056
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350
 
ttg ccc aaa gtt tat gat ctt atg gaa aaa ggt aaa att ttg ggt aga   1104
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365
 
tat gtt gtt gat acc tct aaa                                       1125
Tyr Val Val Asp Thr Ser Lys
    370                 375
 

<210> 96
<211> 375
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 96
Met Leu Arg Thr Ser Thr Leu Phe Thr Lys Arg Val Gln Pro Ser Leu
 1               5                  10                  15      
Phe Ser Arg Asn Ile Leu Arg Leu Gln Ser Thr Ala Ala Ile Pro Lys
            20                  25                  30          
Thr Gln Lys Gly Val Ile Phe Tyr Glu Asn Lys Gly Asn Leu His Tyr
        35                  40                  45              
Lys Asp Ile Pro Val Pro Glu Pro Lys Pro Asn Glu Ile Leu Ile Asn
    50                  55                  60                  
Val Lys Tyr Ser Gly Val Cys His Thr Asp Leu His Ala Trp His Gly
65                  70                  75                  80  
Asp Trp Pro Leu Pro Val Lys Leu Pro Leu Val Gly Gly His Glu Gly
                85                  90                  95      
Ala Gly Val Val Val Lys Leu Gly Ser Asn Val Lys Gly Trp Lys Val
            100                 105                 110         
Gly Asp Leu Ala Gly Ile Lys Trp Leu Asn Gly Ser Cys Met Thr Cys
        115                 120                 125             
Glu Phe Cys Glu Ser Gly His Glu Ser Asn Cys Pro Asp Ala Asp Leu
    130                 135                 140                 
Ser Gly Tyr Thr His Asp Gly Ser Phe Gln Gln Phe Ala Thr Ala Asp
145                 150                 155                 160 
Ala Ile Gln Ala Ala Lys Ile Gln Gln Gly Thr Asp Leu Ala Glu Val
                165                 170                 175     
Ala Pro Ile Leu Cys Ala Gly Val Thr Val Tyr Lys Ala Leu Lys Glu
            180                 185                 190         
Ala Asp Leu Lys Ala Gly Asp Trp Val Ala Ile Ser Gly Ala Ala Gly
        195                 200                 205             
Gly Leu Gly Ser Leu Ala Val Gln Tyr Ala Thr Ala Met Gly Tyr Arg
    210                 215                 220                 
Val Leu Gly Ile Asp Ala Gly Glu Glu Lys Glu Lys Leu Phe Lys Lys
225                 230                 235                 240 
Leu Gly Gly Glu Val Phe Ile Asp Phe Thr Lys Thr Lys Asn Met Val
                245                 250                 255     
Ser Asp Ile Gln Glu Ala Thr Lys Gly Gly Pro His Gly Val Ile Asn
            260                 265                 270         
Val Ser Val Ser Glu Ala Ala Ile Ser Leu Ser Thr Glu Tyr Val Arg
        275                 280                 285             
Pro Cys Gly Thr Val Val Leu Val Gly Leu Pro Ala Asn Ala Tyr Val
    290                 295                 300                 
Lys Ser Glu Val Phe Ser His Val Val Lys Ser Ile Asn Ile Lys Gly
305                 310                 315                 320 
Ser Tyr Val Gly Asn Arg Ala Asp Thr Arg Glu Ala Leu Asp Phe Phe
                325                 330                 335     
Ser Arg Gly Leu Ile Lys Ser Pro Ile Lys Ile Val Gly Leu Ser Glu
            340                 345                 350         
Leu Pro Lys Val Tyr Asp Leu Met Glu Lys Gly Lys Ile Leu Gly Arg
        355                 360                 365             
Tyr Val Val Asp Thr Ser Lys
    370                 375 


<210> 97
<211> 1008
<212> DNA
<213> S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1008)

<400> 97
atg tct gaa cca gct caa aag aaa caa aag gtt gct aac aac tct cta   48
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                   10                  15
 
gaa caa ttg aaa gcc tcc ggc act gtc gtt gtt gcc gac act ggt gat   96
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
             20                  25                  30
 
ttc ggc tct att gcc aag ttt caa cct caa gac tcc aca act aac cca   144
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
         35                  40                  45
 
tca ttg atc ttg gct gct gcc aag caa cca act tac gcc aag ttg atc   192
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
     50                  55                  60
 
gat gtt gcc gtg gaa tac ggt aag aag cat ggt aag acc acc gaa gaa   240
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
 65                  70                  75                  80
 
caa gtc gaa aat gct gtg gac aga ttg tta gtc gaa ttc ggt aag gag   288
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                 85                  90                  95
 
atc tta aag att gtt cca ggc aga gtc tcc acc gaa gtt gat gct aga   336
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110
 
ttg tct ttt gac act caa gct acc att gaa aag gct aga cat atc att   384
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125
 
aaa ttg ttt gaa caa gaa ggt gtc tcc aag gaa aga gtc ctt att aaa   432
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140
 
att gct tcc act tgg gaa ggt att caa gct gcc aaa gaa ttg gaa gaa   480
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160
 
aag gac ggt atc cac tgt aat ttg act cta tta ttc tcc ttc gtt caa   528
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175
 
gca gtt gcc tgt gcc gag gcc caa gtt act ttg att tcc cca ttt gtt   576
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190
 
ggt aga att cta gac tgg tac aaa tcc agc act ggt aaa gat tac aag   624
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205
 
ggt gaa gcc gac cca ggt gtt att tcc gtc aag aaa atc tac aac tac   672
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220
 
tac aag aag tac ggt tac aag act att gtt atg ggt gct tct ttc aga   720
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240
 
agc act gac gaa atc aaa aac ttg gct ggt gtt gac tat cta aca att   768
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255
 
tct cca gct tta ttg gac aag ttg atg aac agt act gaa cct ttc cca   816
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270
 
aga gtt ttg gac cct gtc tcc gct aag aag gaa gcc ggc gac aag att   864
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285
 
tct tac atc agc gac gaa tct aaa ttc aga ttc gac ttg aat gaa gac   912
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300
 
gct atg gcc act gaa aaa ttg tcc gaa ggt atc aga aaa ttc tct gcc   960
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320
 
gat att gtt act cta ttc gac ttg att gaa aag aaa gtt acc gct taa   1008
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala  *
                325                 330                 335
 


<210> 98
<211> 335
<212> PRT
<213> S. cerevisiae

<400> 98
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                  10                  15      
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
            20                  25                  30          
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
        35                  40                  45              
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
    50                  55                  60                  
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
65                  70                  75                  80  
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                85                  90                  95      
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110         
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125             
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140                 
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160 
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175     
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190         
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205             
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220                 
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240 
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255     
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270         
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285             
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300                 
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320 
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335 


<210> 99
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in S. cerevisiae

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 99
atg tct gaa cca gct caa aag aag caa aag gtt gcc aat aat tct ttg   48
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                   10                  15
 
gaa caa tta aag gca tct ggt act gtt gtt gtt gct gat act ggt gat   96
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
             20                  25                  30
 
ttt gga tct att gct aaa ttt caa cca caa gat tca act act aat cca   144
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
         35                  40                  45
 
tct ttg att ttg gct gct gct aaa caa cca act tat gct aaa ttg att   192
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
     50                  55                  60
 
gat gtt gca gtt gaa tat ggt aaa aag cat ggt aaa act act gaa gaa   240
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
 65                  70                  75                  80
 
caa gtt gaa aat gct gtg gat aga ttg ttg gtc gag ttc ggt aaa gaa   288
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                 85                  90                  95
 
att tta aag att gtt cca ggt aga gtt tca aca gaa gtt gat gct aga   336
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110
 
ttg tct ttt gat act caa gct aca att gaa aaa gct aga cat att att   384
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125
 
aaa ttg ttt gaa caa gaa ggt gta tct aaa gaa aga gtt ttg att aaa   432
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140
 
att gct tct aca tgg gaa gga ata cag gca gcg aaa gaa ttg gaa gaa   480
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160
 
aaa gat gga ata cat tgt aat ttg aca ttg ttg ttt tct ttc gtt caa   528
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175
 
gct gtt gcg tgt gct gaa gcc caa gtt aca ttg att tct cct ttc gtt   576
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190
 
ggt aga att ttg gat tgg tat aaa tct tct aca ggt aaa gat tat aaa   624
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205
 
ggt gaa gct gat cca ggt gtg att tct gtt aag aag att tac aac tat   672
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220
 
tat aaa aag tat ggt tat aaa act att gtt atg ggt gct tca ttc aga   720
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240
 
tct aca gat gaa att aaa aat ttg gcg ggt gtt gat tat ttg act att   768
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255
 
tct cct gca ttg ttg gat aaa ttg atg aac tca aca gaa ccg ttt cca   816
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270
 
agg gtt ttg gat cca gta agc gcg aaa aag gaa gct ggc gac aaa att   864
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285
 
tcc tat att tct gat gaa tct aaa ttt agg ttc gat tta aat gaa gat   912
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300
 
gct atg gct aca gaa aaa ttg tct gaa gga att aga aaa ttt tcg gct   960
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320
 
gac att gtc aca tta ttt gat ttg att gag aaa aag gtt act gct       1005
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335
 


<210> 100
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in S. cerevisiae

<400> 100
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                  10                  15      
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
            20                  25                  30          
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
        35                  40                  45              
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
    50                  55                  60                  
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
65                  70                  75                  80  
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                85                  90                  95      
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110         
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125             
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140                 
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160 
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175     
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190         
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205             
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220                 
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240 
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255     
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270         
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285             
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300                 
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320 
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335 


<210> 101
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in E. coli

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 101
atg tct gaa ccg gcg cag aaa aag cag aaa gtt gcg aac aac tct ctc   48
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                   10                  15
 
gaa cag ctg aag gcg tct ggc acc gtt gtt gtt gcg gac act ggc gac   96
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
             20                  25                  30
 
ttc ggt tct atc gcg aaa ttc caa ccg cag gac tct acc acc aac ccg   144
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
         35                  40                  45
 
tct ctg atc ctg gct gcg gct aaa caa ccg acc tac gcg aaa ctg att   192
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
     50                  55                  60
 
gac gtt gct gta gaa tac ggt aag aag cac ggt aaa acc acc gaa gaa   240
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
 65                  70                  75                  80
 
cag gtt gaa aac gct gta gac cgt ctg ctg gtt gag ttc ggt aaa gaa   288
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                 85                  90                  95
 
atc ctg aaa atc gtt ccg ggt cgt gtg tct acc gaa gtt gat gcg cgt   336
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110
 
ttg tct ttc gac acc cag gct acc atc gaa aag gcc cgc cac atc atc   384
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125
 
aaa ctg ttc gaa caa gaa ggt gtg tct aaa gaa cgt gtt ctg atc aaa   432
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140
 
atc gcg tct act tgg gaa ggt atc caa gcg gcc aag gaa ctg gag gaa   480
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160
 
aaa gac ggt atc cac tgc aac ctg acc ctg ctg ttc tct ttc gtt cag   528
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175
 
gct gtt gcg tgc gct gag gct caa gta acc ctc atc agc ccg ttc gtt   576
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190
 
ggt cgt atc ctg gat tgg tac aaa tct tct acc ggt aaa gac tac aaa   624
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205
 
ggt gag gcg gat cca ggt gtt atc tct gtt aag aag atc tac aac tac   672
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220
 
tac aaa aag tac ggt tac aaa acc atc gtt atg ggt gcg tct ttt cgt   720
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240
 
tct acc gac gaa atc aaa aac ctc gca ggt gtt gac tac ctg act atc   768
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255
 
tct ccg gct ctg ctt gac aaa ctg atg aac tct acc gaa ccg ttc cca   816
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270
 
cgt gtt ttg gac cct gtg tct gcg aag aag gag gca ggc gac aaa atc   864
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285
 
tct tac atc tct gac gaa tct aaa ttt cgc ttc gac ctg aat gag gac   912
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300
 
gct atg gct acc gaa aaa ctg tct gaa ggt att cgc aaa ttc tct gcc   960
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320
 
gat att gtt acc ctg ttc gac ctt att gag aag aag gtt acc gct       1005
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335
 


<210> 102
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in E. coli

<400> 102
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                  10                  15      
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
            20                  25                  30          
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
        35                  40                  45              
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
    50                  55                  60                  
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
65                  70                  75                  80  
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                85                  90                  95      
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110         
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125             
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140                 
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160 
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175     
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190         
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205             
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220                 
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240 
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255     
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270         
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285             
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300                 
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320 
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335 


<210> 103
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in P. pastoris

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 103
atg tct gaa cca gct cag aaa aag caa aaa gtt gca aat aat tct tta   48
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                   10                  15
 
gag caa ttg aag gct tct ggt act gtt gtt gtt gct gat act gga gat   96
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
             20                  25                  30
 
ttt ggt tct att gct aaa ttt caa cca caa gat tct act act aat cca   144
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
         35                  40                  45
 
tca ttg att ttg gct gct gct aaa caa cca act tat gct aaa ttg att   192
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
     50                  55                  60
 
gat gtt gcc gtt gaa tat ggt aaa aag cat gga aaa act act gaa gaa   240
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
 65                  70                  75                  80
 
caa gtt gaa aat gca gtt gat aga tta tta gta gag ttc ggt aaa gaa   288
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                 85                  90                  95
 
att ttg aag att gtt cca ggt aga gtt tct act gag gtt gat gct aga   336
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110
 
ttg tct ttt gat act caa gct act att gaa aaa gct aga cat att att   384
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125
 
aaa ttg ttt gag caa gaa gga gtt tct aaa gaa aga gtt ttg att aaa   432
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140
 
att gct tct act tgg gaa gga atc caa gct gcc aag gaa tta gag gaa   480
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160
 
aaa gat ggt ata cat tgt aat ttg aca ttg ttg ttt tct ttt gtt caa   528
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175
 
gca gtt gca tgt gct gag gct caa gtt act tta att tct cca ttt gtt   576
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190
 
gga agg att ctc gat tgg tat aaa tct tct act gga aaa gat tat aaa   624
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205
 
gga gaa gct gat cca gga gtg att agt gtg aaa aag att tac aac tat   672
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220
 
tat aaa aag tat gga tat aaa act att gtt atg gga gct tct ttt aga   720
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240
 
tct act gat gaa att aaa aat ttg gca ggc gta gat tac ttg act att   768
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255
 
tca cct gct ttg cta gat aaa ttg atg aac tca act gaa cca ttt cct   816
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270
 
aga gtt ttg gat cca gtt tct gct aaa aag gaa gct ggg gat aaa att   864
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285
 
agt tac att tct gat gaa tct aag ttc cga ttt gat tta aat gaa gat   912
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300
 
gct atg gct act gaa aaa ttg tct gaa gga att agg aaa ttt agt gct   960
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320
 
gac att gta aca ttg ttt gat ttg att gag aaa aag gtt act gct       1005
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335
 


<210> 104
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in P. pastoris

<400> 104
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                  10                  15      
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
            20                  25                  30          
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
        35                  40                  45              
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
    50                  55                  60                  
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
65                  70                  75                  80  
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                85                  90                  95      
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110         
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125             
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140                 
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160 
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175     
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190         
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205             
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220                 
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240 
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255     
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270         
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285             
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300                 
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320 
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335 


<210> 105
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 105
atg tct gaa cca gct caa aaa aaa caa aaa gtt gct aat aat tca ttg   48
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                   10                  15
 
gaa caa ctt aag gct tca gga act gtt gtt gta gct gat act ggt gat   96
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
             20                  25                  30
 
ttc ggt tct att gct aaa ttc cag cca caa gat tct act act aat cca   144
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
         35                  40                  45
 
tct tta att ttg gct gct gct aaa caa cca act tat gct aaa ttg att   192
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
     50                  55                  60
 
gat gtt gca gtt gaa tat gga aaa aaa cat gga aaa act act gaa gaa   240
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
 65                  70                  75                  80
 
caa gtt gaa aat gct gtg gat aga ttg ttg gtc gaa ttt gga aaa gaa   288
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                 85                  90                  95
 
att tta aaa att gtt cca ggt aga gtt tct act gag gtt gat gct aga   336
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110
 
ttg tct ttc gat act caa gct act att gaa aaa gct aga cat att att   384
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125
 
aaa ttg ttc gag cag gaa ggt gtt agt aaa gaa aga gtt ttg att aaa   432
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140
 
att gct tct act tgg gaa ggc att cag gca gct aaa gaa ttg gaa gaa   480
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160
 
aaa gat ggt ata cat tgt aat ttg aca ttg ttg ttc tct ttc gtt caa   528
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175
 
gcc gtt gcg tgt gct gaa gcg cag gtt act tta att tct cct ttc gtc   576
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190
 
ggt aga atc cta gat tgg tat aaa tct tct act gga aag gat tat aaa   624
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205
 
ggt gaa gct gat ccg gga gtt att tct gtt aaa aaa att tat aat tat   672
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220
 
tat aaa aaa tat ggt tat aaa act att gtt atg ggt gca tct ttc aga   720
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240
 
tct act gat gaa att aaa aat ttg gca ggg gtt gat tac ttg act att   768
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255
 
tct ccg gca tta tta gat aag ttg atg aac tca acc gaa cca ttc cct   816
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270
 
aga gtt tta gat cct gtt tct gct aaa aag gaa gca ggc gac aaa ata   864
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285
 
tct tat att tct gat gag tct aaa ttc aga ttt gat tta aat gaa gat   912
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300
 
gct atg gct act gaa aaa ttg tct gaa gga atc aga aaa ttc tct gct   960
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320
 
gat ata gtt aca ttg ttt gat ttg att gaa aaa aaa gtt act gcg       1005
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335
 


<210> 106
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in K. lactis

<400> 106
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                  10                  15      
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
            20                  25                  30          
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
        35                  40                  45              
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
    50                  55                  60                  
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
65                  70                  75                  80  
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                85                  90                  95      
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110         
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125             
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140                 
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160 
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175     
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190         
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205             
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220                 
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240 
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255     
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270         
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285             
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300                 
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320 
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335 


<210> 107
<211> 1005
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1005)

<400> 107
atg tct gaa ccg gcc caa aag aag cag aaa gtt gcc aac aat tct ttg   48
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                   10                  15
 
gaa cag ttg aaa gcc tct gga acc gtt gtt gtt gcc gat acc ggt gat   96
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
             20                  25                  30
 
ttt ggt tct att gcc aaa ttt cag cca cag gat tct acc acg aat ccg   144
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
         35                  40                  45
 
tct ttg att ttg gct gct gct aag caa cct acg tat gcc aaa ctt att   192
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
     50                  55                  60
 
gat gtt gca gtt gaa tat ggt aaa aag cat ggt aaa acc acc gaa gaa   240
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
 65                  70                  75                  80
 
cag gtt gaa aat gcc gta gat cgt ttg ttg gtt gaa ttt ggt aag gaa   288
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                 85                  90                  95
 
att ttg aaa att gtt ccg ggt cgt gtt tct acc gaa gtt gat gct cgc   336
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110
 
ttg tct ttt gat acg cag gcc acc att gaa aaa gct cgt cat att att   384
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125
 
aaa ttg ttt gaa cag gaa ggt gtt tct aaa gaa cgt gtt ttg att aaa   432
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140
 
att gcc tct acg tgg gaa ggg atc cag gcc gct aaa gaa ttg gaa gaa   480
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160
 
aaa gat ggc att cat tgt aat ttg acc ttg ttg ttt tct ttt gtt cag   528
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175
 
gcg gtc gca tgt gcc gag gct cag gtt acc ttg att tct ccg ttt gta   576
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190
 
ggg cga att ttg gat tgg tat aaa tct tct acc ggt aaa gat tat aaa   624
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205
 
ggt gaa gct gat cct gga gtt atc tct gtt aaa aag att tat aac tat   672
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220
 
tat aaa aag tat ggt tat aaa acg att gtt atg ggt gct tct ttc cgc   720
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240
 
tct act gat gaa att aaa aat ctt gct gga gtg gat tat ttg acc att   768
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255
 
tct cct gca ctc ttg gat aaa ctt atg aat agc acc gaa cct ttt ccg   816
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270
 
cgt gtc cta gac cct gtt tct gcc aaa aag gag gct ggg gat aaa att   864
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285
 
tcg tat att tct gat gaa tct aaa ttt cgt ttt gat ttg aat gaa gat   912
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300
 
gct atg gcg acg gaa aaa ttg tct gaa ggt ata cgt aaa ttt tct gct   960
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320
 
gac att gtt acc tta ttt gat ttg att gaa aag aaa gtt aca gca       1005
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335
 


<210> 108
<211> 335
<212> PRT
<213> Artificial Sequence

<220> 
<223> amino acid sequence encoded by nucleotide sequence
      modified for expression in Z. mobilis

<400> 108
Met Ser Glu Pro Ala Gln Lys Lys Gln Lys Val Ala Asn Asn Ser Leu
 1               5                  10                  15      
Glu Gln Leu Lys Ala Ser Gly Thr Val Val Val Ala Asp Thr Gly Asp
            20                  25                  30          
Phe Gly Ser Ile Ala Lys Phe Gln Pro Gln Asp Ser Thr Thr Asn Pro
        35                  40                  45              
Ser Leu Ile Leu Ala Ala Ala Lys Gln Pro Thr Tyr Ala Lys Leu Ile
    50                  55                  60                  
Asp Val Ala Val Glu Tyr Gly Lys Lys His Gly Lys Thr Thr Glu Glu
65                  70                  75                  80  
Gln Val Glu Asn Ala Val Asp Arg Leu Leu Val Glu Phe Gly Lys Glu
                85                  90                  95      
Ile Leu Lys Ile Val Pro Gly Arg Val Ser Thr Glu Val Asp Ala Arg
            100                 105                 110         
Leu Ser Phe Asp Thr Gln Ala Thr Ile Glu Lys Ala Arg His Ile Ile
        115                 120                 125             
Lys Leu Phe Glu Gln Glu Gly Val Ser Lys Glu Arg Val Leu Ile Lys
    130                 135                 140                 
Ile Ala Ser Thr Trp Glu Gly Ile Gln Ala Ala Lys Glu Leu Glu Glu
145                 150                 155                 160 
Lys Asp Gly Ile His Cys Asn Leu Thr Leu Leu Phe Ser Phe Val Gln
                165                 170                 175     
Ala Val Ala Cys Ala Glu Ala Gln Val Thr Leu Ile Ser Pro Phe Val
            180                 185                 190         
Gly Arg Ile Leu Asp Trp Tyr Lys Ser Ser Thr Gly Lys Asp Tyr Lys
        195                 200                 205             
Gly Glu Ala Asp Pro Gly Val Ile Ser Val Lys Lys Ile Tyr Asn Tyr
    210                 215                 220                 
Tyr Lys Lys Tyr Gly Tyr Lys Thr Ile Val Met Gly Ala Ser Phe Arg
225                 230                 235                 240 
Ser Thr Asp Glu Ile Lys Asn Leu Ala Gly Val Asp Tyr Leu Thr Ile
                245                 250                 255     
Ser Pro Ala Leu Leu Asp Lys Leu Met Asn Ser Thr Glu Pro Phe Pro
            260                 265                 270         
Arg Val Leu Asp Pro Val Ser Ala Lys Lys Glu Ala Gly Asp Lys Ile
        275                 280                 285             
Ser Tyr Ile Ser Asp Glu Ser Lys Phe Arg Phe Asp Leu Asn Glu Asp
    290                 295                 300                 
Ala Met Ala Thr Glu Lys Leu Ser Glu Gly Ile Arg Lys Phe Ser Ala
305                 310                 315                 320 
Asp Ile Val Thr Leu Phe Asp Leu Ile Glu Lys Lys Val Thr Ala
                325                 330                 335 

