                         SEQUENCE LISTING

<110>  The Board of Regents, The University of Texas System
 
<120>  DKK1 As A Universal Tumor Vaccine for Immunotherapy of Cancers

<130>  019856.0242

<140>  Unassigned
<141>  2008-05-19

<150>  US 60/938,955
<151>  2007-05-18

<160>  95    

<170>  PatentIn version 3.4

<210>  1
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  1

Ala Leu Gly Gly His Pro Leu Leu Gly Val 
1               5                   10  


<210>  2
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  2

Tyr Leu Gly Gly His Pro Leu Leu Gly Val 
1               5                   10  


<210>  3
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  3

Ile Leu Tyr Pro Gly Gly Asn Lys Tyr 
1               5                   


<210>  4
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  4

Ile Leu Tyr Pro Gly Gly Asn Lys Val 
1               5                   


<210>  5
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  5

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  6
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  6

Ile Leu Lys Glu Pro Val His Gly Val 
1               5                   


<210>  7
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  7

Val Leu Asn Ser Asn Ala Ile Lys Asn Leu 
1               5                   10  



<210>  8
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  8

Val Leu Asn Ser Asn Ala Ile Lys Asn Val 
1               5                   10  


<210>  9
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  9

Ala Leu Gly Ala Ala Gly Ala Thr Arg Val 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  10

Tyr Leu Gly Ala Ala Gly Ala Thr Arg Val 
1               5                   10  


<210>  11
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  11

Ala Met Cys Cys Pro Gly Asn Tyr Val 
1               5                   


<210>  12
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  12

Thr Leu Ser Ser Lys Met Tyr His Val 
1               5                   



<210>  13
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  13

Tyr Leu Asn Ser Val Leu Asn Ser Asn Val 
1               5                   10  


<210>  14
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  14

Arg Val Phe Val Ala Met Val Ala Ala 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  15

Tyr Leu Leu Gly Val Ser Ala Thr Leu 
1               5                   


<210>  16
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  16

Lys Met Tyr His Thr Lys Gly Gln Glu Gly 
1               5                   10  


<210>  17
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  17

Ile Leu Tyr Pro Gly Gly Asn Lys Val 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  18

Tyr Val Leu Asn Ser Asn Ala Ile Val 
1               5                   


<210>  19
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  19

Gly Leu Glu Ile Phe Gln Arg Cys Tyr 
1               5                   


<210>  20
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  20

Tyr Val Phe Val Ala Met Val Ala Val 
1               5                   


<210>  21
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  21

Phe Val Ala Met Val Ala Ala Ala Leu 
1               5                   


<210>  22
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  22

Val Phe Val Ala Met Val Ala Ala Ala Leu 
1               5                   10  


<210>  23
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  23

His Pro Leu Leu Gly Val Ser Ala Thr Leu 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  24

Val Leu Lys Glu Gly Gln Val Cys Thr Lys 
1               5                   10  


<210>  25
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  25

Ala Met Cys Cys Pro Gly Asn Tyr Cys Lys 
1               5                   10  


<210>  26
<211>  10
<212>  PRT
<213>  Homo Sapiens


<400>  26

Cys Val Ser Ser Asp Gln Asn His Phe Arg 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  27

Gly Val Gln Ile Cys Leu Ala Cys Arg Lys 
1               5                   10  


<210>  28
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  28

Gly Val Gln Ile Cys Leu Ala Cys Arg Lys 
1               5                   10  


<210>  29
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  29

Ser Val Leu Asn Ser Asn Ala Ile Lys 
1               5                   


<210>  30
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  30

Cys Val Ser Ser Asp Gln Asn His Phe Arg 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  31

Cys Tyr Cys Gly Glu Gly Leu Ser Cys Arg 
1               5                   10  


<210>  32
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  32

Glu Ile Glu Glu Thr Ile Thr Glu Arg 
1               5                   


<210>  33
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  33

Cys Val Ser Ser Asp Gln Asn His Phe Arg 
1               5                   10  


<210>  34
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  34

Asp Gly Tyr Ser Arg Arg Thr Thr Leu 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  35

Cys Arg Lys Arg Arg Lys Arg Cys Met 
1               5                   


<210>  36
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  36

Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser 
1               5                   10  


<210>  37
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  37

Glu Glu Cys Gly Thr Asp Glu Tyr Cys Ala 
1               5                   10  


<210>  38
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  38

Gly Asp Ala Gly Val Gln Ile Cys Leu 
1               5                   


<210>  39
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  39

Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu 
1               5                   10  


<210>  40
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  40

Glu Glu Cys Gly Thr Asp Glu Tyr Cys Ala 
1               5                   10  


<210>  41
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  41

Gly Asp Ala Gly Val Gln Ile Cys Leu Ala 
1               5                   10  


<210>  42
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  42

Ile Leu Tyr Pro Gly Gly Asn Lys Tyr 
1               5                   


<210>  43
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  43

Tyr Gln Thr Ile Asp Asn Tyr Gln Pro Tyr 
1               5                   10  


<210>  44
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  44

His Pro Leu Leu Gly Val Ser Ala Thr Leu 
1               5                   10  


<210>  45
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  45

Ala Val Ser Ala Ala Pro Gly Ile Leu 
1               5                   


<210>  46
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  46

Ala Cys Arg Lys Arg Arg Lys Arg Cys Met 
1               5                   10  


<210>  47
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  47

Ser Cys Arg Ile Gln Lys Asp His His Val 
1               5                   10  


<210>  48
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  48

Arg Arg Thr Thr Leu Ser Ser Lys Met Tyr 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  49


Arg Arg Lys Gly Ser His Gly Leu Glu Ile 
1               5                   10  


<210>  50
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  50

His Arg Arg Lys Gly Ser His Gly Leu 
1               5                   


<210>  51
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  51

Ser Arg Arg Thr Thr Leu Ser Ser Lys 
1               5                   


<210>  52
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  52

Arg Ser Ser Asp Cys Ala Ser Gly Leu 
1               5                   


<210>  53
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  53

Trp Ser Lys Ile Cys Lys Pro Val Leu 
1               5                   


<210>  54
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  54

Gly Asp Ala Gly Val Gln Ile Cys Leu 
1               5                   


<210>  55
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  55

Ser Asp Gln Asn His Phe Arg Gly Glu Ile 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  56

His His Gln Ala Ser Asn Ser Ser Arg Leu 
1               5                   10  


<210>  57
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  57

Lys His Arg Arg Lys Gly Ser His Gly Leu 
1               5                   10  


<210>  58
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  58

His His Gln Ala Ser Asn Ser Ser Arg Leu 
1               5                   10  


<210>  59
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  59

Lys His Arg Arg Lys Gly Ser His Gly Leu 
1               5                   10  


<210>  60
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  60

His Gln Ala Ser Asn Ser Ser Arg Leu 
1               5                   


<210>  61
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  61

Thr Lys Gly Gln Glu Gly Ser Val Cys Leu 
1               5                   10  


<210>  62
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  62

Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
1               5                   


<210>  63
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  63

Ile Glu Glu Thr Ile Thr Glu Ser Phe 
1               5                   


<210>  64
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  64

Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile 
1               5                   10  


<210>  65
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  65

Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile 
1               5                   10  


<210>  66
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  66

Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile 
1               5                   10  


<210>  67
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  67

Cys Pro Gly Asn Tyr Cys Lys Asn Gly Ile 
1               5                   10  


<210>  68
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  68

Gly Ala Ala Gly Ala Thr Arg Val Phe Val 
1               5                   10  


<210>  69
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  69

Gly Ala Ala Gly His Pro Gly Ser Ala Val 
1               5                   10  


<210>  70
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  70

Leu Gly Ala Ala Gly Ala Thr Arg Val Phe 
1               5                   10  


<210>  71
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  71

Lys Gly Ser His Gly Leu Glu Ile Phe 
1               5                   


<210>  72
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  72

Ala Ser Gly Leu Cys Cys Ala Arg His Phe 
1               5                   10  


<210>  73
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  73

Gly Ala Ala Gly Ala Thr Arg Val Phe 
1               5                   


<210>  74
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  74

Asn Ala Ile Lys Asn Leu Pro Pro Pro Leu 
1               5                   10  


<210>  75
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  75

Ser Ala Val Ser Ala Ala Pro Gly Ile Leu 
1               5                   10  


<210>  76
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  76

Val Phe Val Ala Met Val Ala Ala Ala Leu 
1               5                   10  


<210>  77
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  77

His Pro Leu Leu Gly Val Ser Ala Thr Leu 
1               5                   10  


<210>  78
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  78

Asn Ala Ile Lys Asn Leu Pro Pro Pro Leu 
1               5                   10  


<210>  79
<211>  10
<212>  PRT
<213>  Homo Sapiens

<400>  79

Gly Ala Thr Arg Val Phe Val Ala Met Val 
1               5                   10  


<210>  80
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  80

Asn Asp His Ser Thr Leu Asp Gly Tyr 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Homo Sapiens

<400>  81

Gln Thr Ile Asp Asn Tyr Gln Pro Tyr 
1               5                   


<210>  82
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  82

Thr Arg Val Phe Val Ala Met Val Ala Ala Ala Leu Gly Gly His 
1               5                   10                  15  


<210>  83
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  83

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala 
1               5                   10                  15  


<210>  84
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  84

Gly Ile Cys Val Ser Ser Asp Gln Asn His Phe Arg Gly Glu Ile 
1               5                   10                  15  


<210>  85
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  85

Leu Leu Gly Val Ser Ala Thr Leu Asn Ser Val Leu Asn Ser Asn 
1               5                   10                  15  


<210>  86
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  86

Ser Ala Thr Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn 
1               5                   10                  15  


<210>  87
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  87

Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys Ile Cys 
1               5                   10                  15  


<210>  88
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  88

Leu Leu Gly Val Ser Ala Thr Leu Asn Ser Val Leu Asn Ser Asn 
1               5                   10                  15  


<210>  89
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  89

Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn Asp 
1               5                   10                  15  


<210>  90
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  90

Arg His Phe Trp Ser Lys Ile Cys Lys Pro Val Leu Lys Glu Gly 
1               5                   10                  15  


<210>  91
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  91

Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr Gln Pro Tyr Pro Cys 
1               5                   10                  15  


<210>  92
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  92

Tyr Gln Thr Ile Asp Asn Tyr Gln Pro Tyr Pro Cys Ala Glu Asp 
1               5                   10                  15  


<210>  93
<211>  15
<212>  PRT
<213>  Homo Sapiens

<400>  93

Ala Gly Ala Thr Arg Val Phe Val Ala Met Val Ala Ala Ala Leu 
1               5                   10                  15  


<210>  94
<211>  801
<212>  DNA
<213>  Homo Sapiens

<400>  94
atgatggctc tgggcgcagc gggagctacc cgggtctttg tcgcgatggt agcggcggct     60

ctcggcggcc accctctgct gggagtgagc gccaccttga actcggttct caattccaac    120

gctatcaaga acctgccccc accgctgggc ggcgctgcgg ggcacccagg ctctgcagtc    180

agcgccgcgc cgggaatcct gtacccgggc gggaataagt accagaccat tgacaactac    240

cagccgtacc cgtgcgcaga ggacgaggag tgcggcactg atgagtactg cgctagtccc    300

acccgcggag gggacgcagg cgtgcaaatc tgtctcgcct gcaggaagcg ccgaaaacgc    360

tgcatgcgtc acgctatgtg ctgccccggg aattactgca aaaatggaat atgtgtgtct    420

tctgatcaaa atcatttccg aggagaaatt gaggaaacca tcactgaaag ctttggtaat    480

gatcatagca ccttggatgg gtattccaga agaaccacct tgtcttcaaa aatgtatcac    540

accaaaggac aagaaggttc tgtttgtctc cggtcatcag actgtgcctc aggattgtgt    600

tgtgctagac acttctggtc caagatctgt aaacctgtcc tgaaagaagg tcaagtgtgt    660

accaagcata ggagaaaagg ctctcatgga ctagaaatat tccagcgttg ttactgtgga    720

gaaggtctgt cttgccggat acagaaagat caccatcaag ccagtaattc ttctaggctt    780

cacacttgtc agagacacta a                                              801


<210>  95
<211>  266
<212>  PRT
<213>  Homo Sapiens

<400>  95

Met Met Ala Leu Gly Ala Ala Gly Ala Thr Arg Val Phe Val Ala Met 
1               5                   10                  15      


Val Ala Ala Ala Leu Gly Gly His Pro Leu Leu Gly Val Ser Ala Thr 
            20                  25                  30          


Leu Asn Ser Val Leu Asn Ser Asn Ala Ile Lys Asn Leu Pro Pro Pro 
        35                  40                  45              


Leu Gly Gly Ala Ala Gly His Pro Gly Ser Ala Val Ser Ala Ala Pro 
    50                  55                  60                  


Gly Ile Leu Tyr Pro Gly Gly Asn Lys Tyr Gln Thr Ile Asp Asn Tyr 
65                  70                  75                  80  


Gln Pro Tyr Pro Cys Ala Glu Asp Glu Glu Cys Gly Thr Asp Glu Tyr 
                85                  90                  95      


Cys Ala Ser Pro Thr Arg Gly Gly Asp Ala Gly Val Gln Ile Cys Leu 
            100                 105                 110         


Ala Cys Arg Lys Arg Arg Lys Arg Cys Met Arg His Ala Met Cys Cys 
        115                 120                 125             


Pro Gly Asn Tyr Cys Lys Asn Gly Ile Cys Val Ser Ser Asp Gln Asn 
    130                 135                 140                 


His Phe Arg Gly Glu Ile Glu Glu Thr Ile Thr Glu Ser Phe Gly Asn 
145                 150                 155                 160 


Asp His Ser Thr Leu Asp Gly Tyr Ser Arg Arg Thr Thr Leu Ser Ser 
                165                 170                 175     


Lys Met Tyr His Thr Lys Gly Gln Glu Gly Ser Val Cys Leu Arg Ser 
            180                 185                 190         


Ser Asp Cys Ala Ser Gly Leu Cys Cys Ala Arg His Phe Trp Ser Lys 
        195                 200                 205             


Ile Cys Lys Pro Val Leu Lys Glu Gly Gln Val Cys Thr Lys His Arg 
    210                 215                 220                 


Arg Lys Gly Ser His Gly Leu Glu Ile Phe Gln Arg Cys Tyr Cys Gly 
225                 230                 235                 240 


Glu Gly Leu Ser Cys Arg Ile Gln Lys Asp His His Gln Ala Ser Asn 
                245                 250                 255     


Ser Ser Arg Leu His Thr Cys Gln Arg His 
            260                 265     


2

