                               SEQUENCE LISTING                               

<110> WYETH

<120> NOVEL PRIMATE CHITINASES AND USES THEREFOR

<130> W2023-7008WO

<140>
<141>

<150> 60/930,777
<151> 2007-05-18

<160> 47                            

<170> PatentIn Ver. 3.3

<210> 1
<211> 1425
<212> DNA
<213> Macaca fascicularis

<400> 1
atggccaagc ttaccctcct cactggtctg ctccttgtgc tgacagctga gataggctct 60    
gcttaccagc tgacatgcta cttctccaac tgggcccagt accggccagg cctggggcgc 120   
ttcatgcctg acgacatcga cccctgcctc tgtacccacc tgatctacgc ctttgctggg 180   
atgcagaaca acaagatcac caccatcgaa tggaatgacg tgactctcta ccaagctttc 240   
aatggcctga aaaacaaaaa tagtcaactg aaaactctct tggctattgg tggctggaac 300   
tttggcactg ctcctttcac tgccatggtt tccactcctg cgaaccgcca gactttcatc 360   
aactcagtca tcgaattcct gcgccagtat gagtttgatg ggctggactt cgactgggag 420   
taccccggct ctcgtgggag cccttctcag gacaagcatc tcttcactgt cctggtgcag 480   
gaaacgcgtg aagcttttga gcaggaggcc aagcagagca acaagcccag gctgctggtc 540   
actgctgcag tagctgctgg catctccacc atccaatctg gctacgagat cccccaactg 600   
tcgcagtacc tggactacat ccacgtcatg acctacgacc tccatggccc ctgggagggc 660   
tacacaggag agaacagccc cctgtacaaa tacccgactg acactggcag taacgcctac 720   
ctcaatgtgg attatgccat caactactgg aagaacaacg gggccccagc tgagaagctc 780   
atcgttggat tcccagccta tggacatacc ttccttctga gcaatccctc cgatcatgga 840   
attggcgccc ctaccactgg tcctggccct gctgggccct ataccaggga gtctgggttc 900   
tgggcctact atgagatctg taccttcctg aagaatggag ctactgaagt atgggaggct 960   
aatgaggatg ttccctatgc ctacaaagga aatgagtggc ttggatatga taacaccaag 1020  
agtttccaaa tcaaggctga ctggctaaag aagaacaact tcggaggcgc catggtctgg 1080  
gccattgact tggatgattt cacaggcact ttctgcaatg aaggaaaatt ccctctgatc 1140  
accaccctaa aggatgctct gggcctgcag agtacaagtt gcaaagctcc agcccaaccc 1200  
attactccca ttactgaggc acccgtcaca ggcagcgtca gccacagtgg tagctctggg 1260  
ggcagcccca gtgatagtga attctgtgcc aacaaggcca atggcctgta ccctgacccc 1320  
actgacaaga atgccttcta caattgtgca aatggaaaga ctttcattca gcactgccag 1380  
gctggccttg tcttcgaagc ctcctgctcc tgctgcagct ggtga                 1425  


<210> 2
<211> 474
<212> PRT
<213> Macaca fascicularis

<400> 2
Met Ala Lys Leu Thr Leu Leu Thr Gly Leu Leu Leu Val Leu Thr Ala  
  1               5                  10                  15    

Glu Ile Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Ser Asn Trp Ala  
             20                  25                  30        

Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asp Ile Asp Pro  
         35                  40                  45            

Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn  
     50                  55                  60                

Lys Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe  
 65                  70                  75                  80

Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile  
                 85                  90                  95    

Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr  
            100                 105                 110        

Pro Ala Asn Arg Gln Thr Phe Ile Asn Ser Val Ile Glu Phe Leu Arg  
        115                 120                 125            

Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser  
    130                 135                 140                

Arg Gly Ser Pro Ser Gln Asp Lys His Leu Phe Thr Val Leu Val Gln  
145                 150                 155                 160

Glu Thr Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ser Asn Lys Pro  
                165                 170                 175    

Arg Leu Leu Val Thr Ala Ala Val Ala Ala Gly Ile Ser Thr Ile Gln  
            180                 185                 190        

Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His  
        195                 200                 205            

Val Met Thr Tyr Asp Leu His Gly Pro Trp Glu Gly Tyr Thr Gly Glu  
    210                 215                 220                

Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr  
225                 230                 235                 240

Leu Asn Val Asp Tyr Ala Ile Asn Tyr Trp Lys Asn Asn Gly Ala Pro  
                245                 250                 255    

Ala Glu Lys Leu Ile Val Gly Phe Pro Ala Tyr Gly His Thr Phe Leu  
            260                 265                 270        

Leu Ser Asn Pro Ser Asp His Gly Ile Gly Ala Pro Thr Thr Gly Pro  
        275                 280                 285            

Gly Pro Ala Gly Pro Tyr Thr Arg Glu Ser Gly Phe Trp Ala Tyr Tyr  
    290                 295                 300                

Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Glu Val Trp Glu Ala  
305                 310                 315                 320

Asn Glu Asp Val Pro Tyr Ala Tyr Lys Gly Asn Glu Trp Leu Gly Tyr  
                325                 330                 335    

Asp Asn Thr Lys Ser Phe Gln Ile Lys Ala Asp Trp Leu Lys Lys Asn  
            340                 345                 350        

Asn Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr  
        355                 360                 365            

Gly Thr Phe Cys Asn Glu Gly Lys Phe Pro Leu Ile Thr Thr Leu Lys  
    370                 375                 380                

Asp Ala Leu Gly Leu Gln Ser Thr Ser Cys Lys Ala Pro Ala Gln Pro  
385                 390                 395                 400

Ile Thr Pro Ile Thr Glu Ala Pro Val Thr Gly Ser Val Ser His Ser  
                405                 410                 415    

Gly Ser Ser Gly Gly Ser Pro Ser Asp Ser Glu Phe Cys Ala Asn Lys  
            420                 425                 430        

Ala Asn Gly Leu Tyr Pro Asp Pro Thr Asp Lys Asn Ala Phe Tyr Asn  
        435                 440                 445            

Cys Ala Asn Gly Lys Thr Phe Ile Gln His Cys Gln Ala Gly Leu Val  
    450                 455                 460                

Phe Glu Ala Ser Cys Ser Cys Cys Ser Trp                          
465                 470                


<210> 3
<211> 1449
<212> DNA
<213> Homo sapiens

<400> 3
atggccaagc tcaccctcct cactggtctg ctccttgtgc tgacagctga aataggctct 60    
gcctaccagc tgacatgtta cttcaccaac tgggcccaga accagccagg cctggggtgc 120   
ttcaagcctg atgacatcga cccctgcctc tgtacccact tgatctacgc ctttgctgga 180   
atgcagaaca acgagatcac caccatcgaa tgggatgaca tgactctcta ccaagctttc 240   
aatggcctga aaaacaagaa tagtcaactg aaaactctct tggctattgg tggctggaac 300   
tttggcactg ctccgttcac tgccatggtt tccactcctg agaaccacca gactttcatc 360   
aactcagtca tcaaattcct gcgccagtat gagtttgacg ggctggactt tgactgggag 420   
taccccggct ctcgtgtgag ccctcctcag gacaagcatc tcttcactgt cctggtgcag 480   
gaaatgcgtg aagcttttga gcaggaggcc aagcacatta ataagcccag gctgatggtc 540   
actgctgcag tagctgctgg catctccaac atccagtctg gctatgagat cccccaactg 600   
tcacagtacc cggactacat ccatgtcatg acctatgacc tccatggctc ctgggagggc 660   
tacactggag agaacagccc cctctacaaa tacccgactg acaccggcag caacgcctac 720   
ctcaatgtgg attatgtcat gaactactgg aaggacaaca gggccccagc tgagaagctc 780   
ttggttggat tcccagccta tggacactcc ttccttctga gcaacccctc caaccatgga 840   
attgatgccc ctaccactgg tcctggccct gctggaccct ataccaggca gtctgggttc 900   
tgggcctact atgagatctg taccttcctg aagaatggag ctactgaagt atgggaggct 960   
tctgaggatg ttccctatgc ctacaaagga aatgagtggc ttggatacga taacaccaag 1020  
agtttccaaa tcaaggcaga ttggctaaag aagaacaact ttggaggtgc catggtctgg 1080  
gccattgacc tggatgattt cacaggcact ttctgcaacc aaggaaaatt ccctctgatc 1140  
accaccctga aggatgctct gggcctgcag agtacaagtt gcaaagctcc agcccaaccc 1200  
attgctccca ttgccgaggc aaacatcaca tgcggtgtca gccacagtgg tagctctggg 1260  
ggccgctctg gcaggagctc tgggggcagc cccagaggta gtggattctg tgctgacagg 1320  
gccagtggcc tgtaccctga ccccactgac aagaatgcct cctacagttg tgtgaatgga 1380  
aagactttca ctcagcactg ccagcctggt ggtgtctttg ataccttctg ctcctgctgc 1440  
agctggtga                                                         1449  


<210> 4
<211> 482
<212> PRT
<213> Homo sapiens

<400> 4
Met Ala Lys Leu Thr Leu Leu Thr Gly Leu Leu Leu Val Leu Thr Ala  
  1               5                  10                  15    

Glu Ile Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala  
             20                  25                  30        

Gln Asn Gln Pro Gly Leu Gly Cys Phe Lys Pro Asp Asp Ile Asp Pro  
         35                  40                  45            

Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn  
     50                  55                  60                

Glu Ile Thr Thr Ile Glu Trp Asp Asp Met Thr Leu Tyr Gln Ala Phe  
 65                  70                  75                  80

Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile  
                 85                  90                  95    

Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr  
            100                 105                 110        

Pro Glu Asn His Gln Thr Phe Ile Asn Ser Val Ile Lys Phe Leu Arg  
        115                 120                 125            

Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser  
    130                 135                 140                

Arg Val Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln  
145                 150                 155                 160

Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys His Ile Asn Lys Pro  
                165                 170                 175    

Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln  
            180                 185                 190        

Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Pro Asp Tyr Ile His  
        195                 200                 205            

Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu  
    210                 215                 220                

Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr  
225                 230                 235                 240

Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Arg Ala Pro  
                245                 250                 255    

Ala Glu Lys Leu Leu Val Gly Phe Pro Ala Tyr Gly His Ser Phe Leu  
            260                 265                 270        

Leu Ser Asn Pro Ser Asn His Gly Ile Asp Ala Pro Thr Thr Gly Pro  
        275                 280                 285            

Gly Pro Ala Gly Pro Tyr Thr Arg Gln Ser Gly Phe Trp Ala Tyr Tyr  
    290                 295                 300                

Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Glu Val Trp Glu Ala  
305                 310                 315                 320

Ser Glu Asp Val Pro Tyr Ala Tyr Lys Gly Asn Glu Trp Leu Gly Tyr  
                325                 330                 335    

Asp Asn Thr Lys Ser Phe Gln Ile Lys Ala Asp Trp Leu Lys Lys Asn  
            340                 345                 350        

Asn Phe Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr  
        355                 360                 365            

Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Thr Thr Leu Lys  
    370                 375                 380                

Asp Ala Leu Gly Leu Gln Ser Thr Ser Cys Lys Ala Pro Ala Gln Pro  
385                 390                 395                 400

Ile Ala Pro Ile Ala Glu Ala Asn Ile Thr Cys Gly Val Ser His Ser  
                405                 410                 415    

Gly Ser Ser Gly Gly Arg Ser Gly Arg Ser Ser Gly Gly Ser Pro Arg  
            420                 425                 430        

Gly Ser Gly Phe Cys Ala Asp Arg Ala Ser Gly Leu Tyr Pro Asp Pro  
        435                 440                 445            

Thr Asp Lys Asn Ala Ser Tyr Ser Cys Val Asn Gly Lys Thr Phe Thr  
    450                 455                 460                

Gln His Cys Gln Pro Gly Gly Val Phe Asp Thr Phe Cys Ser Cys Cys  
465                 470                 475                 480

Ser Trp                                                          
                                                               

<210> 5
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 5
tcagaacata taaaaagctc tgcgg                                       25    


<210> 6
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 6
ctctagggaa tatagaccag gtcaggt                                     27    


<210> 7
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 7
tataaatggc aggttggatg aggg                                        24    


<210> 8
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 8
ctgggtgagg tgatatctga aaaatg                                      26    


<210> 9
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 9
ttctcctcac aggtcttgtc ctt                                         23    


<210> 10
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 10
ccagttggtg aagtagcatg tca                                         23    


<210> 11
<211> 26
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 11
atttgcagct cggctctgcc taccag                                      26    


<210> 12
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 12
gcataaggca cttcctgagg g                                           21    


<210> 13
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 13
tgacaacatc aagagcttcg a                                           21    


<210> 14
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 14
agccaaccca cacattgccc tga                                         23    


<210> 15
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 15
ttctgttatt tgccacgggg                                             20    


<210> 16
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 16
cccggcctgg cagttc                                                 16    


<210> 17
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 17
ccttctggca ctgcgtgaat ggagt                                       25    


<210> 18
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 18
acaaggagca gaccagtgag g                                           21    


<210> 19
<211> 24
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 19
tgacatgtta cttcaccaac tggg                                        24    


<210> 20
<211> 30
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 20
ctggtaggca gagcctattt cagctgtcag                                  30    


<210> 21
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 21
cagggcccca gctgaga                                                17    


<210> 22
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 22
gggttgctca gaaggaagga g                                           21    


<210> 23
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 23
ctcttggttg gattcccagc ctatggac                                    28    


<210> 24
<211> 25
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 24
tcctgaagaa tggagctact gaagt                                       25    


<210> 25
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 25
ccaagccact catttccttt g                                           21    


<210> 26
<211> 28
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 26
tgggaggctt ctgaggatgt tccctatg                                    28    


<210> 27
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 27
ggggacaagt ttgtacaaaa aagcaggctt ccaccatggc caagcttacc ctcctcactg 60    


<210> 28
<211> 75
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 28
ggggaccact ttgtacaaga aagctgggtc ctagtgatgg tgatggtgat gccagctgca 60    
gcaggagcag aaggt                                                  75    


<210> 29
<211> 476
<212> PRT
<213> Homo sapiens

<400> 29
Met Thr Lys Leu Ile Leu Leu Thr Gly Leu Val Leu Ile Leu Asn Leu  
  1               5                  10                  15    

Gln Leu Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala  
             20                  25                  30        

Gln Tyr Arg Pro Gly Leu Gly Arg Phe Met Pro Asp Asp Ile Asn Pro  
         35                  40                  45            

Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn  
     50                  55                  60                

Glu Ile Thr Thr Ile Glu Trp Asn Asp Val Thr Leu Tyr Gln Ala Phe  
 65                  70                  75                  80

Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile  
                 85                  90                  95    

Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr  
            100                 105                 110        

Pro Glu Asn Arg Gln Thr Phe Ile Thr Ser Val Ile Lys Phe Leu Arg  
        115                 120                 125            

Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser  
    130                 135                 140                

Arg Gly Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln  
145                 150                 155                 160

Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys Gln Ile Asn Lys Pro  
                165                 170                 175    

Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln  
            180                 185                 190        

Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Leu Asp Tyr Ile His  
        195                 200                 205            

Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu  
    210                 215                 220                

Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr  
225                 230                 235                 240

Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Gly Ala Pro  
                245                 250                 255    

Ala Glu Lys Leu Ile Val Gly Phe Pro Thr Tyr Gly His Asn Phe Ile  
            260                 265                 270        

Leu Ser Asn Pro Ser Asn Thr Gly Ile Gly Ala Pro Thr Ser Gly Ala  
        275                 280                 285            

Gly Pro Ala Gly Pro Tyr Ala Lys Glu Ser Gly Ile Trp Ala Tyr Tyr  
    290                 295                 300                

Glu Ile Cys Thr Phe Leu Lys Asn Gly Ala Thr Gln Gly Trp Asp Ala  
305                 310                 315                 320

Pro Gln Glu Val Pro Tyr Ala Tyr Gln Gly Asn Val Trp Val Gly Tyr  
                325                 330                 335    

Asp Asn Val Lys Ser Phe Asp Ile Lys Ala Gln Trp Leu Lys His Asn  
            340                 345                 350        

Lys Ser Gly Gly Ala Met Val Trp Ala Ile Asp Leu Asp Asp Phe Thr  
        355                 360                 365            

Gly Thr Phe Cys Asn Gln Gly Lys Phe Pro Leu Ile Ser Thr Leu Lys  
    370                 375                 380                

Lys Ala Leu Gly Leu Gln Ser Ala Ser Cys Thr Ala Pro Ala Gln Pro  
385                 390                 395                 400

Ile Glu Pro Ile Thr Ala Ala Pro Ser Gly Ser Gly Asn Gly Ser Gly  
                405                 410                 415    

Ser Ser Ser Ser Gly Gly Ser Ser Gly Gly Ser Gly Phe Cys Ala Gly  
            420                 425                 430        

Arg Ala Asn Gly Leu Tyr Pro Val Ala Asn Asn Arg Asn Ala Phe Trp  
        435                 440                 445            

His Cys Val Asn Gly Val Thr Tyr Gln Gln Asn Cys Gln Ala Gly Leu  
    450                 455                 460                

Val Phe Asp Thr Ser Cys Asp Cys Cys Asn Trp Ala                  
465                 470                 475    


<210> 30
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 30
gctttcaatg gcctgaaaaa caagaatagt caactgaaaa ctctcttggc tattgg     56    


<210> 31
<211> 56
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 31
ccaatagcca agagagtttt cagttgacta ttcttgtttt tcaggccatt gaaagc     56    


<210> 32
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 32
ccccagctga gaagctcttg gttggattcc cagcctatgg ac                    42    


<210> 33
<211> 42
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 33
gtccataggc tgggaatcca accaagagct tctcagctgg gg                    42    


<210> 34
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 34
gcggtgtcag ccacagtggt agctctgggg gccgct                           36    


<210> 35
<211> 36
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 35
agcggccccc agagctacca ctgtggctga caccgc                           36    


<210> 36
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      peptide

<220> 
<221> MOD_RES
<222> (3)
<223> Any amino acid

<220> 
<221> MOD_RES
<222> (5)
<223> Any amino acid

<220> 
<221> MOD_RES
<222> (7)
<223> Any amino acid

<400> 36
Asp Gly Xaa Asp Xaa Asp Xaa Glu                                  
  1               5            


<210> 37
<211> 94
<212> DNA
<213> Homo sapiens

<400> 37
gaagcctttg tgataaccac agaatcagaa catataaaaa gctctgcggg actggtgctg 60    
actgcaacca tgacaaagct tattctcctc acag                             94    


<210> 38
<211> 68
<212> DNA
<213> Homo sapiens

<400> 38
tataaatggc aggttggatg agggacacta ccactgaggc aacatggcca agctcaccct 60    
tctcactg                                                          68    


<210> 39
<211> 120
<212> DNA
<213> Homo sapiens

<400> 39
tcgacaccag ctgtgattgc tgcaactggg cataaacctg acctggtcta tattccctag 60    
agttccagtc tcttttgctt aggacatgtt gcccctacct aaagtcctgc aataaaatca 120   


<210> 40
<211> 87
<212> DNA
<213> Homo sapiens

<400> 40
ttgatacctt ctgctcctgc tgcagctggt gataacattt ttcagatatc acctcaccca 60    
gcctcagaag ttgttgtgca ataaaag                                     87    


<210> 41
<211> 1448
<212> DNA
<213> Homo sapiens

<400> 41
atggccaagc tcacccttct cactggtctg ctccttgtgc tgacagctga aataggctct 60    
gcctaccagc tgacatgtta cttcaccaac tgggcccaga accagccagg cctggggtgc 120   
ttcaagcctg atgacatcga cccctgcctc tgtacccact tgatctacgc ctttgctgga 180   
atgcagaaca acgagatcac caccatcgaa tgggatgaca tgactctcta ccaagctttc 240   
aatggcctga aaaacaagaa tagtcaactg aaaactctct tggctattgg tggctggaac 300   
tttggcactg ctcctttcac tgccatggtt tccactcctg agaaccacca gactttcatc 360   
aactcagtca tcaaattcct gcgccagtat gagtttgacg ggctggactt tgactgggag 420   
taccccggct ctcgtgtgag ccctcctcag gacaagcatc tcttcactgt cctggtgcag 480   
gaaatgcgtg aagcttttga gcaggaggcc aagcacatta ataagcccag gctgatggtc 540   
actgctgcag tagctgctgg catctccaac atccagtctg gctatgagat cccccaactg 600   
tcacagtacc cggactacat ccatgtcatg acctatgacc tccatggctc ctgggagggc 660   
tacactggag agaacagccc cctctacaaa tacccgactg acaccggcag caacgcctac 720   
ctcaatgtgg attatgtcat gaactactgg aaggacaaca gggccccagc tgagaagctc 780   
atgttggatt cccagcctat ggacactcct tccttctgag caacccctcc aaccatggaa 840   
ttgatgcccc taccactggt cctggccctg ctggacccta taccaggcag tctgggttct 900   
gggcctacta tgagatctgt accttcctga agaatggagc tactgaagta tgggaggctt 960   
ctgaggatgt tccctatgcc tacaaaggaa atgagtggct tggatacgat aacaccaaga 1020  
gtttccaaat caaggcagat tggctaaaga agaacaactt tggaggtgcc atggtctggg 1080  
ccattgacct ggatgatttc acaggcactt tctgcaacca aggaaaattc cctctgatca 1140  
ccaccctgaa ggatgctctg ggcctgcaga gtacaagttg caaagctcca gcccaaccca 1200  
ttgctcccat tgccgaggca aacatcacat gcggtgtcag ccacagtcgt agctctgggg 1260  
gccgctctgg caggagctct gggggcagcc ccagaggtag tggattctgt gctgacaggg 1320  
ccagtggcct gtaccctgac cccactgaca agaatgcctc ctacagttgt gtgaatggaa 1380  
agactttcac tcagcactgc cagcctggtg gtgtctttta taccttctgc tcctgctgca 1440  
gctggtga                                                          1448  


<210> 42
<211> 272
<212> PRT
<213> Homo sapiens

<400> 42
Met Ala Lys Leu Thr Leu Leu Thr Gly Leu Leu Leu Val Leu Thr Ala  
  1               5                  10                  15    

Glu Ile Gly Ser Ala Tyr Gln Leu Thr Cys Tyr Phe Thr Asn Trp Ala  
             20                  25                  30        

Gln Asn Gln Pro Gly Leu Gly Cys Phe Lys Pro Asp Asp Ile Asp Pro  
         35                  40                  45            

Cys Leu Cys Thr His Leu Ile Tyr Ala Phe Ala Gly Met Gln Asn Asn  
     50                  55                  60                

Glu Ile Thr Thr Ile Glu Trp Asp Asp Met Thr Leu Tyr Gln Ala Phe  
 65                  70                  75                  80

Asn Gly Leu Lys Asn Lys Asn Ser Gln Leu Lys Thr Leu Leu Ala Ile  
                 85                  90                  95    

Gly Gly Trp Asn Phe Gly Thr Ala Pro Phe Thr Ala Met Val Ser Thr  
            100                 105                 110        

Pro Glu Asn His Gln Thr Phe Ile Asn Ser Val Ile Lys Phe Leu Arg  
        115                 120                 125            

Gln Tyr Glu Phe Asp Gly Leu Asp Phe Asp Trp Glu Tyr Pro Gly Ser  
    130                 135                 140                

Arg Val Ser Pro Pro Gln Asp Lys His Leu Phe Thr Val Leu Val Gln  
145                 150                 155                 160

Glu Met Arg Glu Ala Phe Glu Gln Glu Ala Lys His Ile Asn Lys Pro  
                165                 170                 175    

Arg Leu Met Val Thr Ala Ala Val Ala Ala Gly Ile Ser Asn Ile Gln  
            180                 185                 190        

Ser Gly Tyr Glu Ile Pro Gln Leu Ser Gln Tyr Pro Asp Tyr Ile His  
        195                 200                 205            

Val Met Thr Tyr Asp Leu His Gly Ser Trp Glu Gly Tyr Thr Gly Glu  
    210                 215                 220                

Asn Ser Pro Leu Tyr Lys Tyr Pro Thr Asp Thr Gly Ser Asn Ala Tyr  
225                 230                 235                 240

Leu Asn Val Asp Tyr Val Met Asn Tyr Trp Lys Asp Asn Arg Ala Pro  
                245                 250                 255    

Ala Glu Lys Leu Met Leu Asp Ser Gln Pro Met Asp Thr Pro Ser Phe  
            260                 265                 270        

                                                                 
<210> 43
<211> 36
<212> PRT
<213> Homo sapiens

<400> 43
Ala Thr Pro Pro Thr Met Glu Leu Met Pro Leu Pro Leu Val Leu Ala  
  1               5                  10                  15    

Leu Leu Asp Pro Ile Pro Gly Ser Leu Gly Ser Gly Pro Thr Met Arg  
             20                  25                  30        

Ser Val Pro Ser                                                  
         35    


<210> 44
<211> 38
<212> PRT
<213> Homo sapiens

<400> 44
Arg Met Glu Leu Leu Lys Tyr Gly Arg Leu Leu Arg Met Phe Pro Met  
  1               5                  10                  15    

Pro Thr Lys Glu Met Ser Gly Leu Asp Thr Ile Thr Pro Arg Val Ser  
             20                  25                  30        

Lys Ser Arg Gln Ile Gly                                          
         35            


<210> 45
<211> 29
<212> PRT
<213> Homo sapiens

<400> 45
Arg Arg Thr Thr Leu Glu Val Pro Trp Ser Gly Pro Leu Thr Trp Met  
  1               5                  10                  15    

Ile Ser Gln Ala Leu Ser Ala Thr Lys Glu Asn Ser Leu              
             20                  25                


<210> 46
<211> 74
<212> PRT
<213> Homo sapiens

<400> 46
Arg Met Leu Trp Ala Cys Arg Val Gln Val Ala Lys Leu Gln Pro Asn  
  1               5                  10                  15    

Pro Leu Leu Pro Leu Pro Arg Gln Thr Ser His Ala Val Ser Ala Thr  
             20                  25                  30        

Val Val Ala Leu Gly Ala Ala Leu Ala Gly Ala Leu Gly Ala Ala Pro  
         35                  40                  45            

Glu Val Val Asp Ser Val Leu Thr Gly Pro Val Ala Cys Thr Leu Thr  
     50                  55                  60                

Pro Leu Thr Arg Met Pro Pro Thr Val Val                          
 65                  70                


<210> 47
<211> 24
<212> PRT
<213> Homo sapiens

<400> 47
Met Glu Arg Leu Ser Leu Ser Thr Ala Ser Leu Val Val Ser Phe Ile  
  1               5                  10                  15    

Pro Ser Ala Pro Ala Ala Ala Gly                                  
             20                




       



