                         SEQUENCE LISTING

<110>  Duke University
       Kuan, Chien-Tsun
       Bigner, Darrell
 
<120>  ANTI-MRP3 ANTIBODIES AND METHODS OF USE

<130>  D118 1010.PCT

<150>  US 60/868,133
<151>  2006-12-01

<160>  55    

<170>  PatentIn version 3.4

<210>  1
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Asp Ala Leu Cys Gly Ser Gly Glu Leu Gly Ser Lys Phe Trp Asp 
1               5                   10                  15      


Ser Asn Leu Ser 
            20  


<210>  2
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  2

Val His Thr Glu Asn Pro Asp Leu Thr Pro Cys Phe 
1               5                   10          


<210>  3
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  3

Asp Ala Met Ala Asp Ser Arg Gln Asn Asn Thr Ser Leu Arg Leu 
1               5                   10                  15  


<210>  4
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  4

Lys Ile Arg Ser Pro Gln Ser Phe Phe Asp Thr Thr Pro Ser Gly Arg 
1               5                   10                  15      


Ile 
    


<210>  5
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  5

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Arg Pro Tyr Pro Leu Asp Val Trp Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  6
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Glu Ser His 
            20                  25                  30          


Ala Val Asn Trp Tyr Gln His Leu Pro Gly Ser Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Phe Asn Asn His Arg Pro Ser Gly Val Pro Glu Arg Phe Ser 
    50                  55                  60                  


Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Ala Pro Ser 
        115             


<210>  7
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  7

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Asp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  8
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly Gly 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser Gly 
            20                  25                  30          


Tyr Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg Ala 
        35                  40                  45              


Leu Ile Tyr Ser Thr Ser Asn Lys His Ser Trp Thr Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly Val 
65                  70                  75                  80  


Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly Gly 
                85                  90                  95      


Ala Gln Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val Leu 
            100                 105                 110         


Gly Gln Pro Lys Ala Ala Pro Ser 
        115                 120 


<210>  9
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Asp Pro Gly Lys Gly Leu Met Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Thr Asp Gly Ser Ala Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Gly Gly Phe Leu Gly Trp Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser 
        


<210>  10
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  10

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Gly Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Ser Tyr Phe Cys Gln Gln Thr Asn Thr Phe Pro 
                85                  90                  95      


Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 
            100                 105                 110         


Ala Pro Thr Ala Ala Ala 
        115             


<210>  11
<211>  121
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Asn Tyr 
            20                  25                  30          


Ala Gly Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ala Leu Ser Ser Gly Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Ala Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Asp Pro Val Val Gly Ala Pro Gly Tyr Phe Gly Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  12
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Ser Gly Gln 
1               5                   10                  15      


Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Ile Gly Gly Tyr 
            20                  25                  30          


Asn Tyr Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 
        35                  40                  45              


Met Ile Tyr Glu Val Ser Lys Arg Pro Ser Gly Val Ser Asp Arg Phe 
    50                  55                  60                  


Ser Gly Ser Lys Ser Gly Ser Thr Ala Ser Leu His Ile Ser Gly Leu 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Ser Tyr Ser Ser Asn 
                85                  90                  95      


Asn Ala Pro Tyr Val Phe Gly Ser Gly Thr Lys Val Ala Val Leu Gly 
            100                 105                 110         


Gln Pro Lys Ala Ala Pro Ser 
        115                 


<210>  13
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  13

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Thr Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Ser Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


His Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Gly Asn Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser 
        115                 120 


<210>  14
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Ser Ala Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Glu Ala Trp Asp Asp Ser Leu 
                85                  90                  95      


Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln 
            100                 105                 110         


Pro Lys Ala Thr Pro Ser 
        115             


<210>  15
<211>  15
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic linker

<400>  15

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  16
<211>  750
<212>  DNA
<213>  Homo sapiens

<400>  16
gaggtgcagc tggtgcagtc tgggggaggc ttggtccagc ctggggggtc cctgagactc     60

tcctgttcag cctctggatt caccttcagt aactatgcta tgcactgggt ccgccgggct    120

ccagggaagg gactggaata tgtttcagct attagtagta atgggggtag cacatactac    180

gcagactccg tgaagggcag attcaccatc tccagagaca atcccaagaa cacgctgtat    240

ctgcaaatga acagtctgag agccgaggac acggctgtgt attactgtgt aagagggcgt    300

ccctacccgc tggacgtctg gggcaaaggc accctggtca ccgtctcctc aggtggcggc    360

ggttccggag gtggtggttc tggcggtggt ggcagccagt ctgtgctgac tcagccaccc    420

tcagcgtctg ggacccccgg gcagagggtc accatctctt gttctggcag cagctccaac    480

atcgaaagtc atgctgttaa ttggtatcag cacctcccag gatcggcccc caaactcctc    540

atctatttca ataatcaccg gccctcgggg gtccctgagc gattctctgc ctccaagtct    600

ggcacctcag cctccctggc catcagtggg ctccagtctg aggatgaggc tgattattac    660

tgtgcagcat gggatgacag cctgaatggt ccggtattcg gcggagggac caagctgacc    720

gtcctaggtc agcccaaggc tgccccctcg                                     750


<210>  17
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  17
gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc     60

tcctgtgcag cctctggatt cacctttagt aactatgcca tgacctgggt ccgccaggct    120

ccagggaagg ggctggagtg ggtctcagct attagtggta gtggtggtag cacatactac    180

gcagactccg tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat    240

ctgcaaatga acagcctgag agccgaggac acggccgtat attactgtgc gacgggcgac    300

cttgactact ggggccaggg gaccacggtc accgtctcct caggtggcgg cggttccgga    360

ggtggtggtt ctggcggtgg tggcagccag actgtggtga ctcaggagcc ctcactgact    420

gtgtccccag gagggacagt cactctcacc tgtgcttcca gcactggagc agtcaccagt    480

ggttactatc caaactggtt ccagcagaaa cctggacaag cacccagggc actgatttat    540

agtacaagca acaaacactc ctggacccct gcccggttct caggctccct ccttgggggc    600

aaagctgccc tgacactgtc aggtgtgcag cctgaggacg aggctgagta ttactgcctg    660

ctctactatg gtggtgctca gccttatgtg gtattcggcg gagggaccaa ggtgaccgtc    720

ctcggtcagc ccaaggctgc cccctcg                                        747


<210>  18
<211>  741
<212>  DNA
<213>  Homo sapiens

<400>  18
caggtgcagc tggtgcagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc     60

tcctgtgcag cgtctggatt caccttcagt agctatggca tgcactgggt ccgccaggat    120

ccagggaagg ggctgatgtg ggtctcatct attagtactg atgggagtgc cacaaaatac    180

gcggactccg tgaagggccg attcaccatc tccagagaca acgccaagaa cacggtgtct    240

ctacaaatga acagtctgag agccgaagac acggctgtct attattgtgt aggaggattt    300

ttaggctggt ggggccaggg caccctggtc accgtctctt caggtggcgg cggttccgga    360

ggtggtggtt ctggcggtgg tggcagcgaa attgtgttga cgcagtctcc agccaccctg    420

tctttgtctc caggggaaag agccaccctc tcctgcaggg ccagccagag tgttggcggc    480

agctacttag cctggtacca acagaaacct ggccaggctc ccaggctcct catctatggt    540

gcatccagga gggccactgg catcccagcc aggttcagtg gcagtgggtc tgggacagat    600

ttcacgctca ccatcagcag tctgcaacct gaagattttg caagttactt ttgtcaacag    660

actaacactt ttcctctcac cttcggcggg gggaccaagg tggagatcaa acgaactgtg    720

gctgcaccaa cggcggccgc a                                              741


<210>  19
<211>  765
<212>  DNA
<213>  Homo sapiens

<400>  19
gaggtgcagc tggtgcagtc tgggggaggc ttggtcaagc ctggagggtc cctgagactc     60

tcctgtgcag cctctggatt cagcttcaac aactatgccg ggagctgggt ccgccaggct    120

ccagggaagg ggctggaatg gatctcagca ttgagtagtg gtggtgatac cacatactac    180

gcagactccg tggcgggccg cttcgccatc tccagagaca attccaagaa tactctgtat    240

ctccaaatgc acagtctgag agccgaggac acggccatat attattgtgc gcaggatccc    300

gtcgtgggag cacctgggta cttcggtctc tggggccgtg gaaccctggt caccgtctcc    360

tcaggtggcg gcggttccgg aggtggtggt tctggcggtg gtggcagcca gtctgtgctg    420

actcagccac cctccgcgtc cgggtcttct ggacagtcag tcaccatctc ctgcactgga    480

accagcagtg acattggtgg ttataactat gtctcctggt accaacagca cccaggcaaa    540

gcccccaaac tcatgattta tgaggtcagt aagcggccct caggggtttc tgatcgcttc    600

tctggctcca agtctggcag cacggcctcc ctgcacatct ctggcctcca ggctgaggac    660

gaggcagatt attactgcag ctcatactca agcaacaacg ctccttatgt cttcggaagt    720

gggaccaagg tcgccgtcct aggtcagccc aaggccgccc cctcg                    765


<210>  20
<211>  759
<212>  DNA
<213>  Homo sapiens

<400>  20
caggtacagc tgcagcagtc aggtccagga ctggtgaagc cctcgcagac cctctcactc     60

acctgtgcca tctccgggga cagtgtctct accaacagtg ctgcttggaa ctggatcagg    120

cagtccccat cgagaggcct tgagtggctg ggaaggacat actacaggtc caagtggtat    180

aatgattatg cagtatctgt gaaaagtcga ataaccatca gcccagacac atccaagaat    240

cacttctccc tgcagctgaa ctctgtgact cccgaggaca cggctgtgta ttactgtgca    300

agagagggaa atgatgcttt tgatatctgg ggccaaggga caatggtcac cgtctcctca    360

ggtggcggcg gttccggagg tggtggttct ggcggtggtg gcagccagtc tgccctgact    420

cagccaccct cagcgtctgg gacccccggg cagagggtca ccatctcttg ttctggaagc    480

agctccaaca tcggaagtaa tactgtaaac tggtaccagc agctcccagg aacggccccc    540

aaactcctca tctatagtaa taatcagcgg ccctcagggg tccctgaccg attctctggc    600

tccaagtctg gcacctcagc ctccctggcc atcagtgggc tccagtctga ggatgaagct    660

gattattact gtgaagcatg ggatgacagc ctgaatggtc cggtgttcgg cggagggacc    720

aagctgaccg tcctaggtca gcccaaggct accccctcg                           759


<210>  21
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  21

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ser Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Arg Ala Pro Gly Lys Gly Leu Glu Tyr Val 
        35                  40                  45              


Ser Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Arg Gly Arg Pro Tyr Pro Leu Asp Val Trp Gly Lys Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
        115                 120                 125             


Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly 
    130                 135                 140                 


Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn 
145                 150                 155                 160 


Ile Glu Ser His Ala Val Asn Trp Tyr Gln His Leu Pro Gly Ser Ala 
                165                 170                 175     


Pro Lys Leu Leu Ile Tyr Phe Asn Asn His Arg Pro Ser Gly Val Pro 
            180                 185                 190         


Glu Arg Phe Ser Ala Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile 
        195                 200                 205             


Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp 
    210                 215                 220                 


Asp Asp Ser Leu Asn Gly Pro Val Phe Gly Gly Gly Thr Lys Leu Thr 
225                 230                 235                 240 


Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
                245                 250 


<210>  22
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  22

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Ala Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Thr Gly Asp Leu Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Gln Thr Val Val Thr Gln Glu Pro Ser Leu Thr Val Ser Pro Gly 
    130                 135                 140                 


Gly Thr Val Thr Leu Thr Cys Ala Ser Ser Thr Gly Ala Val Thr Ser 
145                 150                 155                 160 


Gly Tyr Tyr Pro Asn Trp Phe Gln Gln Lys Pro Gly Gln Ala Pro Arg 
                165                 170                 175     


Ala Leu Ile Tyr Ser Thr Ser Asn Lys His Ser Trp Thr Pro Ala Arg 
            180                 185                 190         


Phe Ser Gly Ser Leu Leu Gly Gly Lys Ala Ala Leu Thr Leu Ser Gly 
        195                 200                 205             


Val Gln Pro Glu Asp Glu Ala Glu Tyr Tyr Cys Leu Leu Tyr Tyr Gly 
    210                 215                 220                 


Gly Ala Gln Pro Tyr Val Val Phe Gly Gly Gly Thr Lys Val Thr Val 
225                 230                 235                 240 


Leu Gly Gln Pro Lys Ala Ala Pro Ser 
                245                 


<210>  23
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  23

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Gly Met His Trp Val Arg Gln Asp Pro Gly Lys Gly Leu Met Trp Val 
        35                  40                  45              


Ser Ser Ile Ser Thr Asp Gly Ser Ala Thr Lys Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Thr Val Ser 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Val Gly Gly Phe Leu Gly Trp Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
        115                 120                 125             


Ser Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro 
    130                 135                 140                 


Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Gly 
145                 150                 155                 160 


Ser Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu 
                165                 170                 175     


Leu Ile Tyr Gly Ala Ser Arg Arg Ala Thr Gly Ile Pro Ala Arg Phe 
            180                 185                 190         


Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu 
        195                 200                 205             


Gln Pro Glu Asp Phe Ala Ser Tyr Phe Cys Gln Gln Thr Asn Thr Phe 
    210                 215                 220                 


Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val 
225                 230                 235                 240 


Ala Ala Pro Thr Ala Ala Ala 
                245         


<210>  24
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  24

Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Phe Asn Asn Tyr 
            20                  25                  30          


Ala Gly Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Ser Ala Leu Ser Ser Gly Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Ala Gly Arg Phe Ala Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met His Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Gln Asp Pro Val Val Gly Ala Pro Gly Tyr Phe Gly Leu Trp Gly 
            100                 105                 110         


Arg Gly Thr Leu Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly 
        115                 120                 125             


Gly Gly Ser Gly Gly Gly Gly Ser Gln Ser Val Leu Thr Gln Pro Pro 
    130                 135                 140                 


Ser Ala Ser Gly Ser Ser Gly Gln Ser Val Thr Ile Ser Cys Thr Gly 
145                 150                 155                 160 


Thr Ser Ser Asp Ile Gly Gly Tyr Asn Tyr Val Ser Trp Tyr Gln Gln 
                165                 170                 175     


His Pro Gly Lys Ala Pro Lys Leu Met Ile Tyr Glu Val Ser Lys Arg 
            180                 185                 190         


Pro Ser Gly Val Ser Asp Arg Phe Ser Gly Ser Lys Ser Gly Ser Thr 
        195                 200                 205             


Ala Ser Leu His Ile Ser Gly Leu Gln Ala Glu Asp Glu Ala Asp Tyr 
    210                 215                 220                 


Tyr Cys Ser Ser Tyr Ser Ser Asn Asn Ala Pro Tyr Val Phe Gly Ser 
225                 230                 235                 240 


Gly Thr Lys Val Ala Val Leu Gly Gln Pro Lys Ala Ala Pro Ser 
                245                 250                 255 


<210>  25
<211>  253
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Gln Leu Gln Gln Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ala Ile Ser Gly Asp Ser Val Ser Thr Asn 
            20                  25                  30          


Ser Ala Ala Trp Asn Trp Ile Arg Gln Ser Pro Ser Arg Gly Leu Glu 
        35                  40                  45              


Trp Leu Gly Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala 
    50                  55                  60                  


Val Ser Val Lys Ser Arg Ile Thr Ile Ser Pro Asp Thr Ser Lys Asn 
65                  70                  75                  80  


His Phe Ser Leu Gln Leu Asn Ser Val Thr Pro Glu Asp Thr Ala Val 
                85                  90                  95      


Tyr Tyr Cys Ala Arg Glu Gly Asn Asp Ala Phe Asp Ile Trp Gly Gln 
            100                 105                 110         


Gly Thr Met Val Thr Val Ser Ser Gly Gly Gly Gly Ser Gly Gly Gly 
        115                 120                 125             


Gly Ser Gly Gly Gly Gly Ser Gln Ser Ala Leu Thr Gln Pro Pro Ser 
    130                 135                 140                 


Ala Ser Gly Thr Pro Gly Gln Arg Val Thr Ile Ser Cys Ser Gly Ser 
145                 150                 155                 160 


Ser Ser Asn Ile Gly Ser Asn Thr Val Asn Trp Tyr Gln Gln Leu Pro 
                165                 170                 175     


Gly Thr Ala Pro Lys Leu Leu Ile Tyr Ser Asn Asn Gln Arg Pro Ser 
            180                 185                 190         


Gly Val Pro Asp Arg Phe Ser Gly Ser Lys Ser Gly Thr Ser Ala Ser 
        195                 200                 205             


Leu Ala Ile Ser Gly Leu Gln Ser Glu Asp Glu Ala Asp Tyr Tyr Cys 
    210                 215                 220                 


Glu Ala Trp Asp Asp Ser Leu Asn Gly Pro Val Phe Gly Gly Gly Thr 
225                 230                 235                 240 


Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Thr Pro Ser 
                245                 250             


<210>  26
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  26

Ser Asn Tyr Ala Met His 
1               5       


<210>  27
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  27

Ala Ile Ser Ser Asn Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  28
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  28

Gly Arg Pro Tyr Pro Leu Asp Val 
1               5               


<210>  29
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Ser Ser Ser Asn Ile Glu Ser His Ala Val Asn 
1               5                   10          


<210>  30
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  30

Phe Asn Asn His Arg Pro Ser 
1               5           


<210>  31
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  31

Ala Ala Trp Asp Asp Ser Leu 
1               5           


<210>  32
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  32

Asn Tyr Ala Met Thr 
1               5   


<210>  33
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  33

Ala Ile Ser Gly Ser Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  34
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  34

Gly Asp Leu Asp Tyr 
1               5   


<210>  35
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  35

Ser Ser Thr Gly Ala Val Thr Ser Gly Tyr Tyr Pro Asn 
1               5                   10              


<210>  36
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  36

Ser Thr Ser Asn Lys His Ser 
1               5           


<210>  37
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  37

Leu Leu Tyr Tyr Gly Gly Ala Gln Pro Tyr Val Val 
1               5                   10          


<210>  38
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  38

Ser Tyr Gly Met His 
1               5   


<210>  39
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  39

Ser Ile Ser Thr Asp Gly Gly Ser Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  40
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  40

Gly Phe Leu Gly Trp 
1               5   


<210>  41
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  41

Arg Ala Ser Gln Ser Val Gly Gly Ser Tyr Leu Ala 
1               5                   10          


<210>  42
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  42

Gly Ala Ser Arg Arg Ala Thr 
1               5           


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Gln Gln Thr Asn Thr Phe Pro Leu Thr 
1               5                   


<210>  44
<211>  4
<212>  PRT
<213>  Homo sapiens

<400>  44

Asn Tyr Ala Gly 
1               


<210>  45
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  45

Ala Leu Ser Ser Gly Gly Asp Thr Thr Tyr Tyr Ala Asp Ser Val Ala 
1               5                   10                  15      


Gly 
    


<210>  46
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  46

Asp Pro Val Val Gly Ala Pro Gly Tyr Phe Gly Leu 
1               5                   10          


<210>  47
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  47

Gly Thr Ser Ser Asp Ile Gly Gly Tyr Asn Tyr Val Ser 
1               5                   10              


<210>  48
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Val Ser Lys Arg Pro Ser 
1               5           


<210>  49
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  49

Ser Ser Tyr Ser Ser Asn Asn Ala Pro Tyr Val 
1               5                   10      


<210>  50
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  50

Asn Ser Ala Ala Trp Asn 
1               5       


<210>  51
<211>  18
<212>  PRT
<213>  Homo sapiens

<400>  51

Arg Thr Tyr Tyr Arg Ser Lys Trp Tyr Asn Asp Tyr Ala Val Ser Val 
1               5                   10                  15      


Lys Ser 
        


<210>  52
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  52

Glu Gly Asn Asp Ala Phe Asp Ile 
1               5               


<210>  53
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  53

Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 
1               5                   10          


<210>  54
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Asn Asn Gln Arg Pro Ser 
1               5           


<210>  55
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  55

Glu Ala Trp Asp Asp Ser Leu Asn Gly Pro Val 
1               5                   10      


