                         SEQUENCE LISTING

<110>  Emory University
 
<120>  PRODUCTION OF ANTI-MICROBIAL PEPTIDES

<130>  6975-76901-02

<150>  US 60/867,070
<151>  2006-11-22

<160>  53    

<170>  PatentIn version 3.3

<210>  1
<211>  37
<212>  PRT
<213>  Homo sapiens

<400>  1

Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
1               5                   10                  15      


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
            20                  25                  30          


Pro Arg Thr Glu Ser 
        35          


<210>  2
<211>  34
<212>  PRT
<213>  Mus musculus

<400>  2

Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys 
1               5                   10                  15      


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro 
            20                  25                  30          


Glu Gln 
        


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Cys Tyr Cys Arg Ile Pro Ala Cys Ile Ala Gly Glu Arg Arg Tyr 
1               5                   10                  15      


Gly Thr Cys Ile Tyr Gln Gly Arg Leu Trp Ala Phe Cys Cys 
            20                  25                  30  


<210>  4
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Cys Ser Cys Arg Leu Val Phe Cys Arg Arg Thr Glu Leu Arg Val 
1               5                   10                  15      


Gly Asn Cys Leu Ile Gly Gly Val Ser Phe Thr Tyr Cys Cys Thr Arg 
            20                  25                  30          


Val Asp 
        


<210>  5
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Arg Ala Thr Cys Tyr Cys Arg Thr Gly Arg Cys Ala Thr Arg Glu 
1               5                   10                  15      


Ser Leu Ser Gly Val Cys Glu Ile Ser Gly Arg Leu Tyr Arg Leu Cys 
            20                  25                  30          


Cys Arg 
        


<210>  6
<211>  33
<212>  PRT
<213>  Homo sapiens

<400>  6

Arg Ala Phe Thr Cys His Cys Arg Arg Ser Cys Tyr Ser Thr Glu Tyr 
1               5                   10                  15      


Ser Tyr Gly Thr Cys Thr Val Met Gly Ile Asn His Arg Phe Cys Cys 
            20                  25                  30          


Leu 
    


<210>  7
<211>  36
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp His Tyr Asn Cys Val Ser Ser Gly Gly Gln Cys Leu Tyr Ser Ala 
1               5                   10                  15      


Cys Pro Ile Phe Thr Lys Ile Gln Gly Thr Cys Tyr Arg Gly Lys Ala 
            20                  25                  30          


Lys Cys Cys Lys 
        35      


<210>  8
<211>  40
<212>  PRT
<213>  Homo sapiens

<400>  8

Ile Gly Asp Pro Val Thr Cys Leu Lys Ser Gly Ala Ile Cys His Pro 
1               5                   10                  15      


Val Phe Cys Pro Arg Arg Tyr Lys Gln Ile Gly Thr Cys Gly Leu Pro 
            20                  25                  30          


Gly Thr Lys Cys Cys Lys Lys Pro 
        35                  40  


<210>  9
<211>  39
<212>  PRT
<213>  Homo sapiens

<400>  9

Gln Lys Tyr Tyr Cys Arg Val Arg Gly Gly Arg Cys Ala Val Leu Ser 
1               5                   10                  15      


Cys Leu Pro Lys Glu Glu Gln Ile Gly Lys Cys Ser Thr Arg Gly Arg 
            20                  25                  30          


Lys Cys Cys Arg Arg Lys Lys 
        35                  


<210>  10
<211>  46
<212>  PRT
<213>  Homo sapiens

<400>  10

Leu Asp Arg Ile Cys Gly Tyr Gly Thr Ala Arg Cys Arg Lys Lys Cys 
1               5                   10                  15      


Arg Ser Gln Glu Tyr Arg Ile Gly Arg Cys Pro Asn Thr Tyr Ala Cys 
            20                  25                  30          


Cys Leu Arg Lys Trp Asp Glu Ser Leu Leu Asn Arg Thr Lys 
        35                  40                  45      


<210>  11
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Arg Gln Arg Leu Leu Pro Ser Val Thr Ser Leu Leu Leu Val Ala 
1               5                   10                  15      


Leu Leu Phe Pro Gly Ser Ser Gln Ala Arg His Val Asn His Ser Ala 
            20                  25                  30          


Thr Glu Ala Leu Gly Glu Leu Arg Glu Arg Ala Pro Gly Gln Gly Thr 
        35                  40                  45              


Asn Gly Phe Gln Leu Leu Arg His Ala Val Lys Arg Asp Leu Leu Pro 
    50                  55                  60                  


Pro Arg Thr Pro Pro Tyr Gln Val His Ile Ser His Arg Glu Ala Arg 
65                  70                  75                  80  


Gly Pro Ser Phe Arg Ile Cys Val Asp Phe Leu Gly Pro Arg Trp Ala 
                85                  90                  95      


Arg Gly Cys Ser Thr Gly Asn 
            100             


<210>  12
<211>  50
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Val Phe Phe Leu Phe Ala Val Leu Phe Cys Leu Val Gln Thr 
1               5                   10                  15      


Asn Ser Val His Ile Ser His Arg Glu Ala Arg Gly Pro Ser Phe Arg 
            20                  25                  30          


Ile Cys Val Asp Phe Leu Gly Pro Arg Trp Ala Arg Gly Cys Ser Thr 
        35                  40                  45              


Gly Asn 
    50  


<210>  13
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  FLAG tag

<400>  13

Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
1               5                   


<210>  14
<211>  306
<212>  DNA
<213>  Artificial

<220>
<223>  variant SUMO


<220>
<221>  CDS
<222>  (1)..(306)

<400>  14
atg tcg gac tca gaa gtc aat caa gaa gct aag cca gag gtc aag cca       48
Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro         
1               5                   10                  15              

gaa gtc aag cct gag act cac atc aat tta aag gtg tcc gat gga tct       96
Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser         
            20                  25                  30                  

tca gag atc ttc ttc aag atc aaa aag acc act cct tta aga agg ctg      144
Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu         
        35                  40                  45                      

atg gaa gcg ttc gct aaa aga cag ggt aag gaa atg gac tcc tta aga      192
Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg         
    50                  55                  60                          

ttc ttg tac gac ggt att aga att caa gct gat cag acc cct gaa gat      240
Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp         
65                  70                  75                  80          

ttg gac atg gag gat aac gat att att gag gct cac aga gaa cag att      288
Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile         
                85                  90                  95              

ggt ggt gct acg tat tag                                              306
Gly Gly Ala Thr Tyr                                                     
            100                                                         


<210>  15
<211>  101
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic Construct

<400>  15

Met Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro 
1               5                   10                  15      


Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser 
            20                  25                  30          


Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu 
        35                  40                  45              


Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg 
    50                  55                  60                  


Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp 
65                  70                  75                  80  


Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile 
                85                  90                  95      


Gly Gly Ala Thr Tyr 
            100     


<210>  16
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  16
gcgcgggcat atgggacttc tccgcaaagg tgg                                  33


<210>  17
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  17
gcgcgctcga gctagcactt gtcgtcgtcg tccttgtagt ctttttcttc ttcttcctgc     60

tccggctgag gtacaagt                                                   78


<210>  18
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  18
gcgcgctcga gctactgctc cggctgaggt acaag                                35


<210>  19
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  19
gcgcgccata tgggacttct ccgcgaaggt ggggaggaga tt                        42


<210>  20
<211>  75
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  20
ctactgctcc ggctgaggta caagttcctg aaaaaaattc tcaatttcct ggccaatttc     60

ctcaagctct tcacc                                                      75


<210>  21
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  negative control sequence

<400>  21

Gly Leu Leu Arg Glu Gly Gly Glu Glu Ile Gly Glu Glu Leu Glu Glu 
1               5                   10                  15      


Ile Gly Gln Glu Ile Glu Asn Phe Phe Gln Glu Leu Val Pro Gln Pro 
            20                  25                  30          


Glu Gln 
        


<210>  22
<211>  134
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplary SUMO-AMP fusion protein

<400>  22

Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu 
1               5                   10                  15      


Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser 
            20                  25                  30          


Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met 
        35                  40                  45              


Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe 
    50                  55                  60                  


Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu 
65                  70                  75                  80  


Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly 
                85                  90                  95      


Gly Ala Thr Tyr Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu 
            100                 105                 110         


Lys Leu Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu 
        115                 120                 125             


Val Pro Gln Pro Glu Gln 
    130                 


<210>  23
<211>  135
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary SUMO-AMP fusion protein

<400>  23

Met Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys 
1               5                   10                  15      


Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln 
            20                  25                  30          


Pro Glu Gln Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val 
        35                  40                  45              


Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp 
    50                  55                  60                  


Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg 
65                  70                  75                  80  


Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser 
                85                  90                  95      


Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro 
            100                 105                 110         


Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu 
        115                 120                 125             


Gln Ile Gly Gly Ala Thr Tyr 
    130                 135 


<210>  24
<211>  138
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary SUMO-AMP fusion protein.

<400>  24

Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu 
1               5                   10                  15      


Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser 
            20                  25                  30          


Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met 
        35                  40                  45              


Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe 
    50                  55                  60                  


Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu 
65                  70                  75                  80  


Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly 
                85                  90                  95      


Gly Ala Thr Tyr Gly Gly His Met Gly Leu Leu Arg Lys Gly Gly Glu 
            100                 105                 110         


Lys Ile Gly Glu Lys Leu Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe 
        115                 120                 125             


Phe Gln Lys Leu Val Pro Gln Pro Glu Gln 
    130                 135             


<210>  25
<211>  142
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary SUMO-AMP fusion protein.

<400>  25

Met Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys 
1               5                   10                  15      


Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly 
            20                  25                  30          


Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg 
        35                  40                  45              


Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu 
    50                  55                  60                  


Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu 
65                  70                  75                  80  


Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln 
                85                  90                  95      


Ile Gly Gly Ala Thr Tyr Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile 
            100                 105                 110         


Gly Glu Lys Leu Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln 
        115                 120                 125             


Lys Leu Val Pro Gln Pro Glu Gln His His His His His His 
    130                 135                 140         


<210>  26
<211>  140
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary SUMO-AMP fusion protein.

<400>  26

Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu 
1               5                   10                  15      


Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser 
            20                  25                  30          


Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met 
        35                  40                  45              


Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe 
    50                  55                  60                  


Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu 
65                  70                  75                  80  


Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly 
                85                  90                  95      


Gly Ala Thr Tyr His His His His His His Gly Leu Leu Arg Lys Gly 
            100                 105                 110         


Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys Ile Gly Gln Lys Ile Lys 
        115                 120                 125             


Asn Phe Phe Gln Lys Leu Val Pro Gln Pro Glu Gln 
    130                 135                 140 


<210>  27
<211>  142
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplary SUMO-AMP fusion protein

<400>  27

Met Gly His His His His His His Gly Leu Leu Arg Lys Gly Gly Glu 
1               5                   10                  15      


Lys Ile Gly Glu Lys Leu Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe 
            20                  25                  30          


Phe Gln Lys Leu Val Pro Gln Pro Glu Gln Ser Asp Ser Glu Val Asn 
        35                  40                  45              


Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His 
    50                  55                  60                  


Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile 
65                  70                  75                  80  


Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg 
                85                  90                  95      


Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg 
            100                 105                 110         


Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp 
        115                 120                 125             


Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr 
    130                 135                 140         


<210>  28
<211>  142
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary SUMO-AMP fusion protein.

<400>  28

Met Gly His His His His His His Gly Leu Leu Arg Lys Gly Gly Glu 
1               5                   10                  15      


Lys Ile Gly Glu Lys Leu Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe 
            20                  25                  30          


Phe Gln Lys Leu Val Pro Gln Pro Glu Gln Ser Asp Ser Glu Val Asn 
        35                  40                  45              


Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His 
    50                  55                  60                  


Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile 
65                  70                  75                  80  


Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg 
                85                  90                  95      


Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg 
            100                 105                 110         


Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp 
        115                 120                 125             


Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr 
    130                 135                 140         


<210>  29
<211>  146
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary SUMO-AMP fusion protein

<400>  29

Met Gly Ser Asp Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys 
1               5                   10                  15      


Pro Glu Val Lys Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly 
            20                  25                  30          


Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg 
        35                  40                  45              


Leu Met Glu Ala Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu 
    50                  55                  60                  


Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu 
65                  70                  75                  80  


Asp Leu Asp Met Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln 
                85                  90                  95      


Ile Gly Gly Ala Thr Tyr Gly Gly His Met Gly Leu Leu Arg Lys Gly 
            100                 105                 110         


Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys Ile Gly Gln Lys Ile Lys 
        115                 120                 125             


Asn Phe Phe Gln Lys Leu Val Pro Gln Pro Glu Gln His His His His 
    130                 135                 140                 


His His 
145     


<210>  30
<211>  146
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplary SUMO-AMP fusion protein

<400>  30

Met Gly His His His His His His Val Val His Met Ser Asp Ser Glu 
1               5                   10                  15      


Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu 
            20                  25                  30          


Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe 
        35                  40                  45              


Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala 
    50                  55                  60                  


Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly 
65                  70                  75                  80  


Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp 
                85                  90                  95      


Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr 
            100                 105                 110         


Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys 
        115                 120                 125             


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro 
    130                 135                 140                 


Glu Gln 
145     


<210>  31
<211>  146
<212>  PRT
<213>  Artificial

<220>
<223>  Exemplary SUMO-AMP fusion protein

<400>  31

Met Gly His His His His His His Val Val His Met Gly Leu Leu Arg 
1               5                   10                  15      


Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys Ile Gly Gln Lys 
            20                  25                  30          


Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro Glu Gln Ser Asp 
        35                  40                  45              


Ser Glu Val Asn Gln Glu Ala Lys Pro Glu Val Lys Pro Glu Val Lys 
    50                  55                  60                  


Pro Glu Thr His Ile Asn Leu Lys Val Ser Asp Gly Ser Ser Glu Ile 
65                  70                  75                  80  


Phe Phe Lys Ile Lys Lys Thr Thr Pro Leu Arg Arg Leu Met Glu Ala 
                85                  90                  95      


Phe Ala Lys Arg Gln Gly Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr 
            100                 105                 110         


Asp Gly Ile Arg Ile Gln Ala Asp Gln Thr Pro Glu Asp Leu Asp Met 
        115                 120                 125             


Glu Asp Asn Asp Ile Ile Glu Ala His Arg Glu Gln Ile Gly Gly Ala 
    130                 135                 140                 


Thr Tyr 
145     


<210>  32
<211>  146
<212>  PRT
<213>  Artificial

<220>
<223>  exemplary SUMO-AMP fusion protein

<400>  32

Met Gly His His His His His His Ser Asp Ser Glu Val Asn Gln Glu 
1               5                   10                  15      


Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn 
            20                  25                  30          


Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys 
        35                  40                  45              


Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly 
    50                  55                  60                  


Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln 
65                  70                  75                  80  


Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile 
                85                  90                  95      


Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr Gly Gly His Met 
            100                 105                 110         


Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys 
        115                 120                 125             


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro 
    130                 135                 140                 


Glu Gln 
145     


<210>  33
<211>  38
<212>  DNA
<213>  Artificial

<220>
<223>  primer to amplify human LL37

<400>  33
gcgcaattcc atatgaagac ccaaagggat ggccactc                             38


<210>  34
<211>  36
<212>  DNA
<213>  Artificial

<220>
<223>  primer to amplify human LL37

<400>  34
gcgcctcgag ctaggactct gtcctgggta caagat                               36


<210>  35
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  primer to amplify human LL37

<400>  35
gcgcgccata tgctgctggg tgatttcttc cggaa                                35


<210>  36
<211>  513
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(513)

<400>  36
atg aag acc caa agg gat ggc cac tcc ctg ggg cgg tgg tca ctg gtg       48
Met Lys Thr Gln Arg Asp Gly His Ser Leu Gly Arg Trp Ser Leu Val         
1               5                   10                  15              

ctc ctg ctg ctg ggc ctg gtg atg cct ctg gcc atc att gcc cag gtc       96
Leu Leu Leu Leu Gly Leu Val Met Pro Leu Ala Ile Ile Ala Gln Val         
            20                  25                  30                  

ctc agc tac aag gaa gct gtg ctt cgt gct ata gat ggc atc aac cag      144
Leu Ser Tyr Lys Glu Ala Val Leu Arg Ala Ile Asp Gly Ile Asn Gln         
        35                  40                  45                      

cgg tcc tcg gat gct aac ctc tac cgc ctc ctg gac ctg gac ccc agg      192
Arg Ser Ser Asp Ala Asn Leu Tyr Arg Leu Leu Asp Leu Asp Pro Arg         
    50                  55                  60                          

ccc acg atg gat ggg gac cca gac acg cca aag cct gtg agc ttc aca      240
Pro Thr Met Asp Gly Asp Pro Asp Thr Pro Lys Pro Val Ser Phe Thr         
65                  70                  75                  80          

gtg aag gag aca gtg tgc ccc agg acg aca cag cag tca cca gag gat      288
Val Lys Glu Thr Val Cys Pro Arg Thr Thr Gln Gln Ser Pro Glu Asp         
                85                  90                  95              

tgt gac ttc aag aag gac ggg ctg gtg aag cgg tgt atg ggg aca gtg      336
Cys Asp Phe Lys Lys Asp Gly Leu Val Lys Arg Cys Met Gly Thr Val         
            100                 105                 110                 

acc ctc aac cag gcc agg ggc tcc ttt gac atc agt tgt gat aag gat      384
Thr Leu Asn Gln Ala Arg Gly Ser Phe Asp Ile Ser Cys Asp Lys Asp         
        115                 120                 125                     

aac aag aga ttt gcc ctg ctg ggt gat ttc ttc cgg aaa tct aaa gag      432
Asn Lys Arg Phe Ala Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu         
    130                 135                 140                         

aag att ggc aaa gag ttt aaa aga att gtc cag aga atc aag gat ttt      480
Lys Ile Gly Lys Glu Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe         
145                 150                 155                 160         

ttg cgg aat ctt gta ccc agg aca gag tcc tag                          513
Leu Arg Asn Leu Val Pro Arg Thr Glu Ser                                 
                165                 170                                 


<210>  37
<211>  170
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Lys Thr Gln Arg Asp Gly His Ser Leu Gly Arg Trp Ser Leu Val 
1               5                   10                  15      


Leu Leu Leu Leu Gly Leu Val Met Pro Leu Ala Ile Ile Ala Gln Val 
            20                  25                  30          


Leu Ser Tyr Lys Glu Ala Val Leu Arg Ala Ile Asp Gly Ile Asn Gln 
        35                  40                  45              


Arg Ser Ser Asp Ala Asn Leu Tyr Arg Leu Leu Asp Leu Asp Pro Arg 
    50                  55                  60                  


Pro Thr Met Asp Gly Asp Pro Asp Thr Pro Lys Pro Val Ser Phe Thr 
65                  70                  75                  80  


Val Lys Glu Thr Val Cys Pro Arg Thr Thr Gln Gln Ser Pro Glu Asp 
                85                  90                  95      


Cys Asp Phe Lys Lys Asp Gly Leu Val Lys Arg Cys Met Gly Thr Val 
            100                 105                 110         


Thr Leu Asn Gln Ala Arg Gly Ser Phe Asp Ile Ser Cys Asp Lys Asp 
        115                 120                 125             


Asn Lys Arg Phe Ala Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu 
    130                 135                 140                 


Lys Ile Gly Lys Glu Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe 
145                 150                 155                 160 


Leu Arg Asn Leu Val Pro Arg Thr Glu Ser 
                165                 170 


<210>  38
<211>  114
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(114)

<400>  38
gcc ctg ctg ggt gat ttc ttc cgg aaa tct aaa gag aag att ggc aaa       48
Ala Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys         
1               5                   10                  15              

gag ttt aaa aga att gtc cag aga atc aag gat ttt ttg cgg aat ctt       96
Glu Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu         
            20                  25                  30                  

gta ccc agg aca gag tcc                                              114
Val Pro Arg Thr Glu Ser                                                 
        35                                                              


<210>  39
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  39

Ala Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys 
1               5                   10                  15      


Glu Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu 
            20                  25                  30          


Val Pro Arg Thr Glu Ser 
        35              


<210>  40
<211>  149
<212>  PRT
<213>  Artificial

<220>
<223>  His tag-SUMO-LL37 fusion protein

<400>  40

Met Gly His His His His His His Ser Asp Ser Glu Val Asn Gln Glu 
1               5                   10                  15      


Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn 
            20                  25                  30          


Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys 
        35                  40                  45              


Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly 
    50                  55                  60                  


Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln 
65                  70                  75                  80  


Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile 
                85                  90                  95      


Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr Gly Gly His Met 
            100                 105                 110         


Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu 
        115                 120                 125             


Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val 
    130                 135                 140                 


Pro Arg Thr Glu Ser 
145                 


<210>  41
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  mutant CRAMP peptide

<400>  41

Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Glu Lys Leu Lys Lys 
1               5                   10                  15      


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro 
            20                  25                  30          


Glu Gln 
        


<210>  42
<211>  42
<212>  DNA
<213>  Artificial

<220>
<223>  primer to generate mutated CRAMP

<400>  42
gcgcgccata tggatttctt ccgcaaatct aaagagaaga tt                        42


<210>  43
<211>  34
<212>  PRT
<213>  Artificial

<220>
<223>  mutant CRAMP peptide

<400>  43

Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys 
1               5                   10                  15      


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Asn Leu Val Pro Arg Thr 
            20                  25                  30          


Glu Ser 
        


<210>  44
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  44
gcgcctcgag ctaggactct gtccggggta caagatt                              37


<210>  45
<211>  155
<212>  PRT
<213>  Artificial

<220>
<223>  His-SUMO-CRAMP-FLAG tag fusion protein

<400>  45

Met Gly His His His His His His Ser Asp Ser Glu Val Asn Gln Glu 
1               5                   10                  15      


Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn 
            20                  25                  30          


Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys 
        35                  40                  45              


Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly 
    50                  55                  60                  


Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln 
65                  70                  75                  80  


Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile 
                85                  90                  95      


Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr Gly Gly His Met 
            100                 105                 110         


Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys 
        115                 120                 125             


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro 
    130                 135                 140                 


Glu Gln Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
145                 150                 155 


<210>  46
<211>  45
<212>  PRT
<213>  Artificial

<220>
<223>  Resulting peptide when SEQ ID NO: 45 treated with sumoase

<400>  46

His Met Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu 
1               5                   10                  15      


Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro 
            20                  25                  30          


Gln Pro Glu Gln Asp Tyr Lys Asp Asp Asp Asp Lys Gly 
        35                  40                  45  


<210>  47
<211>  146
<212>  PRT
<213>  Artificial

<220>
<223>  His-SUMO-CRAMP fusion protein

<400>  47

Met Gly His His His His His His Ser Asp Ser Glu Val Asn Gln Glu 
1               5                   10                  15      


Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn 
            20                  25                  30          


Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys 
        35                  40                  45              


Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly 
    50                  55                  60                  


Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln 
65                  70                  75                  80  


Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile 
                85                  90                  95      


Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr Gly Gly His Met 
            100                 105                 110         


Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys 
        115                 120                 125             


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro 
    130                 135                 140                 


Glu Gln 
145     


<210>  48
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  resulting protein when SEQ ID NO: 47 treated with sumoase

<400>  48

His Met Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu 
1               5                   10                  15      


Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro 
            20                  25                  30          


Gln Pro Glu Gln 
        35      


<210>  49
<211>  146
<212>  PRT
<213>  Artificial

<220>
<223>  His-SUMO-CRAMP-M1 fusion protein

<400>  49

Met Gly His His His His His His Ser Asp Ser Glu Val Asn Gln Glu 
1               5                   10                  15      


Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn 
            20                  25                  30          


Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys 
        35                  40                  45              


Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly 
    50                  55                  60                  


Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln 
65                  70                  75                  80  


Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile 
                85                  90                  95      


Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr Gly Gly His Met 
            100                 105                 110         


Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Glu Lys Leu Lys Lys 
        115                 120                 125             


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro Gln Pro 
    130                 135                 140                 


Glu Gln 
145     


<210>  50
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  resulting peptide when SEQ ID NO: 40 treated with sumoase

<400>  50

His Met Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Glu Lys Leu 
1               5                   10                  15      


Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Lys Leu Val Pro 
            20                  25                  30          


Gln Pro Glu Gln 
        35      


<210>  51
<211>  146
<212>  PRT
<213>  Artificial

<220>
<223>  His-SUMO-CRAMP-M2 fusion protein

<400>  51

Met Gly His His His His His His Ser Asp Ser Glu Val Asn Gln Glu 
1               5                   10                  15      


Ala Lys Pro Glu Val Lys Pro Glu Val Lys Pro Glu Thr His Ile Asn 
            20                  25                  30          


Leu Lys Val Ser Asp Gly Ser Ser Glu Ile Phe Phe Lys Ile Lys Lys 
        35                  40                  45              


Thr Thr Pro Leu Arg Arg Leu Met Glu Ala Phe Ala Lys Arg Gln Gly 
    50                  55                  60                  


Lys Glu Met Asp Ser Leu Arg Phe Leu Tyr Asp Gly Ile Arg Ile Gln 
65                  70                  75                  80  


Ala Asp Gln Thr Pro Glu Asp Leu Asp Met Glu Asp Asn Asp Ile Ile 
                85                  90                  95      


Glu Ala His Arg Glu Gln Ile Gly Gly Ala Thr Tyr Gly Gly His Met 
            100                 105                 110         


Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu Lys Lys 
        115                 120                 125             


Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Asn Leu Val Pro Arg Thr 
    130                 135                 140                 


Glu Ser 
145     


<210>  52
<211>  36
<212>  PRT
<213>  Artificial

<220>
<223>  resulting sequence when SEQ ID NO: 51 treated with sumoase.

<400>  52

His Met Gly Leu Leu Arg Lys Gly Gly Glu Lys Ile Gly Glu Lys Leu 
1               5                   10                  15      


Lys Lys Ile Gly Gln Lys Ile Lys Asn Phe Phe Gln Asn Leu Val Pro 
            20                  25                  30          


Arg Thr Glu Ser 
        35      


<210>  53
<211>  39
<212>  PRT
<213>  Artificial

<220>
<223>  resulting peptide when SEQ ID NO: 40 treated with sumoase.

<400>  53

His Met Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly 
1               5                   10                  15      


Lys Glu Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn 
            20                  25                  30          


Leu Val Pro Arg Thr Glu Ser 
        35                  


