
                                SEQUENCE LISTING

<110> Kirsty Salmon
      David Roth
      G. Wesley Hatfield
      Yimeng Dou

<120> CELLOBIOHYDROLASE-ENCODING NUCLEOTIDE
  SEQUENCES WITH REFINED TRANSLATIONAL KINETICS AND METHODS OF
  MAKING SAME

<130> UCI005.011VPC

<150> 60/916,375          
<151> 2007-05-07  

<160> 24

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1416
<212> DNA
<213> Tr. Reesei

<220> 
<221> CDS            
<222> (1)...(1416)

<400> 1
atg att gtc ggc att ctc acc acg ctg gct acg ctg gcc aca ctc gca   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct agt gtg cct cta gag gag cgg caa gct tgc tca agc gtc tgg ggc   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt ggt ggc cag aat tgg tcg ggt ccg act tgc tgt gct tcc gga   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
agc aca tgc gtc tac tcc aac gac tat tac tcc cag tgt ctt ccc ggc   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gca agc tca agc tcg tcc acg cgc gcc gcg tcg acg act tct cga   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gta tcc ccc aca aca tcc cgg tcg agc tcc gcg acg cct cca cct ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct act act acc aga gta cct cca gtc gga tcg gga acc gct acg tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tca ggc aac cct ttt gtt ggg gtc act cct tgg gcc aat gca tat tac   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gcc tct gaa gtt agc agc ctc gct att cct agc ttg act gga gcc atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gcc act gct gca gca gct gtc gca aag gtt ccc tct ttt atg tgg cta   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat act ctt gac aag acc cct ctc atg gag caa acc ttg gcc gac atc   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
cgc acc gcc aac aag aat ggc ggt aac tat gcc gga cag ttt gtg gtg   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gac ttg ccg gat cgc gat tgc gct gcc ctt gcc tcg aat ggc gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tac tct att gcc gat ggt ggc gtc gcc aaa tat aag aac tat atc gac   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
acc att cgt caa att gtc gtg gaa tat tcc gat atc cgg acc ctc ctg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt att gag cct gac tct ctt gcc aac ctg gtg acc aac ctc ggt act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aag tgt gcc aat gct cag tca gcc tac ctt gag tgc atc aac tac   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gcc gtc aca cag ctg aac ctt cca aat gtt gcg atg tat ttg gac gct   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
ggc cat gca gga tgg ctt ggc tgg ccg gca aac caa gac ccg gcc gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
cag cta ttt gca aat gtt tac aag aat gca tcg tct ccg aga gct ctt   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
cgc gga ttg gca acc aat gtc gcc aac tac aac ggg tgg aac att acc   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
agc ccc cca tcg tac acg caa ggc aac gct gtc tac aac gag aag ctg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tac atc cac gct att gga cct ctt ctt gcc aat cac ggc tgg tcc aac   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcc ttc ttc atc act gat caa ggt cga tcg gga aag cag cct acc gga   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
cag caa cag tgg gga gac tgg tgc aat gtg atc ggc acc gga ttt ggt   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
att cgc cca tcc gca aac act ggg gac tcg ttg ctg gat tcg ttt gtc   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtc aag cca ggc ggc gag tgt gac ggc acc agc gac agc agt gcg   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cca cga ttt gac tcc cac tgt gcg ctc cca gat gcc ttg caa ccg gcg   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cct caa gct ggt gct tgg ttc caa gcc tac ttt gtg cag ctt ctc aca   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aac gca aac cca tcg ttc ctg taa                                   1416
Asn Ala Asn Pro Ser Phe Leu  *
465                 470
 

<210> 2
<211> 471
<212> PRT
<213> Tr. Reesei

<400> 2
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 3
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (1)...(1413)

<220> 
<223> sequence modified for expression in S. cerevisiae

<400> 3
atg att gtt gga att ttg act aca ttg gca act cta gct aca ttg gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt cca ttg gaa gaa aga cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt ggt ggt caa aat tgg tct ggt cca act tgt tgt gca tct gga   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tca act tgt gtt tat tct aat gat tat tat tca caa tgt ttg cca gga   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gct tca tct tca tca tca act agg gct gca agt act aca tca agg   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tca cca act act tct aga tca tct tct gcc act ccg cca cca ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tca act act act aga gtt cca ccg gta ggt tct ggt act gct aca tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat cca ttt gta ggt gtt act cca tgg gct aat gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gct tct gaa gtt tca tct ttg gct att cca tct ttg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gcc act gct gct gct gct gtt gca aag gtt cct tct ttt atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat act cta gat aaa act cca ttg atg gaa caa aca ttg gct gat ata   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga act gct aat aaa aac ggt ggt aat tat gct ggt caa ttt gta gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ttg cca gat aga gat tgt gct gct ttg gct tct aat ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gct gat ggt ggt gtt gct aaa tat aaa aat tat att gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
act att aga caa att gtt gtt gaa tat tct gac att aga aca ttg tta   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt ata gaa cca gat tct ttg gct aat ttg gtt act aat tta ggt act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aaa tgt gct aat gct caa tct gct tat ttg gaa tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gct gta act caa tta aat ttg cct aat gtt gct atg tat ttg gat gca   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
ggt cac gca ggt tgg tta ggt tgg cca gct aat caa gat cca gca gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
caa ttg ttt gct aat gtt tat aaa aat gct tct tct cct aga gct ttg   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga ggt tta gca act aat gta gct aat tat aat ggt tgg aat ata act   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tca cca cca tct tat aca caa ggt aat gct gtt tat aat gaa aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gct att ggt cca ttg ttg gct aat cac ggt tgg tct aat   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gct ttc ttt att act gat caa ggt aga tct gga aaa caa cca act ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
cag caa cag tgg ggt gat tgg tgt aat gta att ggt act ggt ttc gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
att aga cca tct gct aat act ggt gat tct ttg ttg gat tct ttc gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cca ggt ggt gaa tgt gat ggt act tct gat tct tct gct   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cct aga ttt gat tct cat tgt gct ttg cca gat gca ttg cag cca gct   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cca cag gcc ggt gca tgg ttt caa gca tat ttc gtt caa ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gct aat cca tca ttt ttg                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 4
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in S. cerevisiae

<400> 4
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 5
<211> 1435
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (12)...(1425)

<220> 
<223> sequence modified for expression in S. cerevisiae

<400> 5
tactcaagct t atg att gtt gga att ttg act aca ttg gca act cta gct  50
             Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala
              1               5                   10
 
aca ttg gct gct tct gtt cca ttg gaa gaa aga cag gct tgt tct tct   98
Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser
     15                  20                  25
 
gtt tgg ggt caa tgt ggt ggt caa aat tgg tct ggt cca act tgt tgt   146
Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys
 30                  35                  40                  45
 
gca tct gga tca act tgt gtt tat tct aat gat tat tat tca caa tgt   194
Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys
                 50                  55                  60
 
ttg cca gga gct gct tca tct tca tca tca act agg gct gca agt act   242
Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr
             65                  70                  75
 
aca tca agg gtt tca cca act act tct aga tca tct tct gcc act ccg   290
Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro
         80                  85                  90
 
cca cca ggt tca act act act aga gtt cca ccg gta ggt tct ggt act   338
Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr
     95                 100                 105
 
gct aca tat tct ggt aat cca ttt gta ggt gtt act cca tgg gct aat   386
Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn
110                 115                 120                 125
 
gct tat tat gct tct gaa gtt tca tct ttg gct att cca tct ttg act   434
Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr
                130                 135                 140
 
ggt gct atg gcc act gct gct gct gct gtt gca aag gtt cct tct ttt   482
Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe
            145                 150                 155
 
atg tgg ttg gat act cta gat aaa act cca ttg atg gaa caa aca ttg   530
Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu
        160                 165                 170
 
gct gat ata aga act gct aat aaa aac ggt ggt aat tat gct ggt caa   578
Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln
    175                 180                 185
 
ttt gta gtt tat gat ttg cca gat aga gat tgt gct gct ttg gct tct   626
Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser
190                 195                 200                 205
 
aat ggt gaa tat tct att gct gat ggt ggt gtt gct aaa tat aaa aat   674
Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn
                210                 215                 220
 
tat att gat act att aga caa att gtt gtt gaa tat tct gac att aga   722
Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg
            225                 230                 235
 
aca ttg tta gtt ata gaa cca gat tct ttg gct aat ttg gtt act aat   770
Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn
        240                 245                 250
 
tta ggt act cca aaa tgt gct aat gct caa tct gct tat ttg gaa tgt   818
Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys
    255                 260                 265
 
att aat tat gct gta act caa tta aat ttg cct aat gtt gct atg tat   866
Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr
270                 275                 280                 285
 
ttg gat gca ggt cac gca ggt tgg tta ggt tgg cca gct aat caa gat   914
Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp
                290                 295                 300
 
cca gca gct caa ttg ttt gct aat gtt tat aaa aat gct tct tct cct   962
Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro
            305                 310                 315
 
aga gct ttg aga ggt tta gca act aat gta gct aat tat aat ggt tgg   1010
Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp
        320                 325                 330
 
aat ata act tca cca cca tct tat aca caa ggt aat gct gtt tat aat   1058
Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn
    335                 340                 345
 
gaa aaa ttg tat att cat gct att ggt cca ttg ttg gct aat cac ggt   1106
Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly
350                 355                 360                 365
 
tgg tct aat gct ttc ttt att act gat caa ggt aga tct gga aaa caa   1154
Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln
                370                 375                 380
 
cca act ggt cag caa cag tgg ggt gat tgg tgt aat gta att ggt act   1202
Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr
            385                 390                 395
 
ggt ttc gga att aga cca tct gct aat act ggt gat tct ttg ttg gat   1250
Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp
        400                 405                 410
 
tct ttc gtt tgg gtt aaa cca ggt ggt gaa tgt gat ggt act tct gat   1298
Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp
    415                 420                 425
 
tct tct gct cct aga ttt gat tct cat tgt gct ttg cca gat gca ttg   1346
Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu
430                 435                 440                 445
 
cag cca gct cca cag gcc ggt gca tgg ttt caa gca tat ttc gtt caa   1394
Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln
                450                 455                 460
 
ttg ttg act aat gct aat cca tca ttt ttg g aattccgatg              1435
Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
            465                 470
 

<210> 6
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in S. cerevisiae

<400> 6
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 7
<211> 1441
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (15)...(1427)

<220> 
<223> sequence modified for expression in S. cerevisiae

<400> 7
gaatactcca tatg atg att gtt gga att ttg act aca ttg gca act cta   50
                Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu
                 1               5                   10
 
gct aca ttg gct gct tct gtt cca ttg gaa gaa aga cag gct tgt tct   98
Ala Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser
         15                  20                  25
 
tct gtt tgg ggt caa tgt ggt ggt caa aat tgg tct ggt cca act tgt   146
Ser Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys
     30                  35                  40
 
tgt gca tct gga tca act tgt gtt tat tct aat gat tat tat tca caa   194
Cys Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln
 45                  50                  55                  60
 
tgt ttg cca gga gct gct tca tct tca tca tca act agg gct gca agt   242
Cys Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser
                 65                  70                  75
 
act aca tca agg gtt tca cca act act tct aga tca tct tct gcc act   290
Thr Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr
             80                  85                  90
 
ccg cca cca ggt tca act act act aga gtt cca ccg gta ggt tct ggt   338
Pro Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly
         95                 100                 105
 
act gct aca tat tct ggt aat cca ttt gta ggt gtt act cca tgg gct   386
Thr Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala
    110                 115                 120
 
aat gct tat tat gct tct gaa gtt tca tct ttg gct att cca tct ttg   434
Asn Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu
125                 130                 135                 140
 
act ggt gct atg gcc act gct gct gct gct gtt gca aag gtt cct tct   482
Thr Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser
                145                 150                 155
 
ttt atg tgg ttg gat act cta gat aaa act cca ttg atg gaa caa aca   530
Phe Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr
            160                 165                 170
 
ttg gct gat ata aga act gct aat aaa aac ggt ggt aat tat gct ggt   578
Leu Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly
        175                 180                 185
 
caa ttt gta gtt tat gat ttg cca gat aga gat tgt gct gct ttg gct   626
Gln Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala
    190                 195                 200
 
tct aat ggt gaa tat tct att gct gat ggt ggt gtt gct aaa tat aaa   674
Ser Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys
205                 210                 215                 220
 
aat tat att gat act att aga caa att gtt gtt gaa tat tct gac att   722
Asn Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile
                225                 230                 235
 
aga aca ttg tta gtt ata gaa cca gat tct ttg gct aat ttg gtt act   770
Arg Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr
            240                 245                 250
 
aat tta ggt act cca aaa tgt gct aat gct caa tct gct tat ttg gaa   818
Asn Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu
        255                 260                 265
 
tgt att aat tat gct gta act caa tta aat ttg cct aat gtt gct atg   866
Cys Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met
    270                 275                 280
 
tat ttg gat gca ggt cac gca ggt tgg tta ggt tgg cca gct aat caa   914
Tyr Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln
285                 290                 295                 300
 
gat cca gca gct caa ttg ttt gct aat gtt tat aaa aat gct tct tct   962
Asp Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser
                305                 310                 315
 
cct aga gct ttg aga ggt tta gca act aat gta gct aat tat aat ggt   1010
Pro Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly
            320                 325                 330
 
tgg aat ata act tca cca cca tct tat aca caa ggt aat gct gtt tat   1058
Trp Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr
        335                 340                 345
 
aat gaa aaa ttg tat att cat gct att ggt cca ttg ttg gct aat cac   1106
Asn Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His
    350                 355                 360
 
ggt tgg tct aat gct ttc ttt att act gat caa ggt aga tct gga aaa   1154
Gly Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys
365                 370                 375                 380
 
caa cca act ggt cag caa cag tgg ggt gat tgg tgt aat gta att ggt   1202
Gln Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly
                385                 390                 395
 
act ggt ttc gga att aga cca tct gct aat act ggt gat tct ttg ttg   1250
Thr Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu
            400                 405                 410
 
gat tct ttc gtt tgg gtt aaa cca ggt ggt gaa tgt gat ggt act tct   1298
Asp Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser
        415                 420                 425
 
gat tct tct gct cct aga ttt gat tct cat tgt gct ttg cca gat gca   1346
Asp Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala
    430                 435                 440
 
ttg cag cca gct cca cag gcc ggt gca tgg ttt caa gca tat ttc gtt   1394
Leu Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val
445                 450                 455                 460
 
caa ttg ttg act aat gct aat cca tca ttt ttg actagtcgat gcct       1441
Gln Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
                465                 470
 

<210> 8
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in S. cerevisiae

<400> 8
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 9
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (1)...(1413)

<220> 
<223> sequence modified for expression in E. coli

<400> 9
atg atc gtt ggt atc ctg acc acc ctc gcg acc ctg gct acc ctg gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt ccg ctc gaa gaa cgt cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
cag tgc ggt ggc caa aat tgg tct ggt cca acc tgc tgc gct tct ggt   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tcc acc tgc gtt tac tct aac gac tac tac tct cag tgt ctg cca ggc   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gcg gcg tcc tct tct tct tct act cgt gcg gct tct acc acc tct cgt   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtg tct ccg acc acc tct cgt tct tct tct gct acc ccg cca cca ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct act act act cgc gtt cca ccg gtt ggt tct ggt act gcg acc tac   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat ccg ttc gtt ggt gtt acc ccg tgg gcg aat gcg tac tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gcg tct gaa gtt agc tct ctc gcg atc ccg tcc ctg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct act gct gcg gct gcg gtt gcg aaa gtt ccg tct ttc atg tgg ctg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gac acc ctg gac aaa acc ccg ctg atg gaa cag acc ctc gcg gac att   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
cgt act gcg aac aaa aac ggt ggc aac tat gcg ggc cag ttt gtt gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tac gac ctc cca gac cgc gac tgc gct gct ctg gct tct aac ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tac tct att gcg gac ggt ggt gtt gcg aaa tac aaa aac tac atc gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
acc atc cgt cag atc gtt gtt gaa tac tct gac atc cgt acc ctg ctg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt atc gaa ccg gac tct ctg gct aat ctg gtt acc aac ctg ggt act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
ccg aaa tgc gcg aat gct cag tct gcg tac ctc gaa tgc atc aac tac   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gcg gtt acc cag ctg aac ctg ccg aac gtt gct atg tac ctg gac gcg   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
ggt cac gct ggt tgg ctg ggt tgg cct gct aat caa gat ccg gct gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
cag ctg ttc gca aac gtt tac aaa aat gcg tct tct ccg cgt gcg ctc   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
cgt ggt ctg gct acc aac gtt gcg aac tac aac ggt tgg aac atc acc   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tcc ccg ccg tct tac acc caa ggt aac gcg gtt tac aac gaa aaa ctg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gcg att ggt cca ctg ctg gct aat cac ggt tgg tct aac   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcg ttc ttc atc acc gat cag ggt cgt tct ggt aaa cag ccg acc ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
caa cag caa tgg ggt gat tgg tgc aac gtt atc ggt act ggt ttc ggt   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
atc cgt ccg tct gcg aac act ggt gac tct ctg ctg gac tct ttc gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cca ggt ggt gaa tgt gac ggt act tct gac tct tct gct   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
ccg cgc ttc gac tct cac tgt gct ctg cca gac gct ctt caa ccg gct   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cca cag gct ggc gcg tgg ttt caa gcg tac ttc gtt cag ctg ctg acc   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gcg aac ccg tct ttc ctg                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 10
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in E. coli

<400> 10
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 11
<211> 1435
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (12)...(1425)

<220> 
<223> sequence modified for expression in E. coli

<400> 11
tactcaagct t atg atc gtt ggt atc ctg acc acc ctc gcg acc ctg gct  50
             Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala
              1               5                   10
 
acc ctg gct gct tct gtt ccg ctc gaa gaa cgt cag gct tgt tct tct   98
Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser
     15                  20                  25
 
gtt tgg ggt cag tgc ggt ggc caa aat tgg tct ggt cca acc tgc tgc   146
Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys
 30                  35                  40                  45
 
gct tct ggt tcc acc tgc gtt tac tct aac gac tac tac tct cag tgt   194
Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys
                 50                  55                  60
 
ctg cca ggc gcg gcg tcc tct tct tct tct act cgt gcg gct tct acc   242
Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr
             65                  70                  75
 
acc tct cgt gtg tct ccg acc acc tct cgt tct tct tct gct acc ccg   290
Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro
         80                  85                  90
 
cca cca ggt tct act act act cgc gtt cca ccg gtt ggt tct ggt act   338
Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr
     95                 100                 105
 
gcg acc tac tct ggt aat ccg ttc gtt ggt gtt acc ccg tgg gcg aat   386
Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn
110                 115                 120                 125
 
gcg tac tat gcg tct gaa gtt agc tct ctc gcg atc ccg tcc ctg act   434
Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr
                130                 135                 140
 
ggt gct atg gct act gct gcg gct gcg gtt gcg aaa gtt ccg tct ttc   482
Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe
            145                 150                 155
 
atg tgg ctg gac acc ctg gac aaa acc ccg ctg atg gaa cag acc ctc   530
Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu
        160                 165                 170
 
gcg gac att cgt act gcg aac aaa aac ggt ggc aac tat gcg ggc cag   578
Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln
    175                 180                 185
 
ttt gtt gtt tac gac ctc cca gac cgc gac tgc gct gct ctg gct tct   626
Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser
190                 195                 200                 205
 
aac ggt gaa tac tct att gcg gac ggt ggt gtt gcg aaa tac aaa aac   674
Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn
                210                 215                 220
 
tac atc gat acc atc cgt cag atc gtt gtt gaa tac tct gac atc cgt   722
Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg
            225                 230                 235
 
acc ctg ctg gtt atc gaa ccg gac tct ctg gct aat ctg gtt acc aac   770
Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn
        240                 245                 250
 
ctg ggt act ccg aaa tgc gcg aat gct cag tct gcg tac ctc gaa tgc   818
Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys
    255                 260                 265
 
atc aac tac gcg gtt acc cag ctg aac ctg ccg aac gtt gct atg tac   866
Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr
270                 275                 280                 285
 
ctg gac gcg ggt cac gct ggt tgg ctg ggt tgg cct gct aat caa gat   914
Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp
                290                 295                 300
 
ccg gct gct cag ctg ttc gca aac gtt tac aaa aat gcg tct tct ccg   962
Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro
            305                 310                 315
 
cgt gcg ctc cgt ggt ctg gct acc aac gtt gcg aac tac aac ggt tgg   1010
Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp
        320                 325                 330
 
aac atc acc tcc ccg ccg tct tac acc caa ggt aac gcg gtt tac aac   1058
Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn
    335                 340                 345
 
gaa aaa ctg tat att cat gcg att ggt cca ctg ctg gct aat cac ggt   1106
Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly
350                 355                 360                 365
 
tgg tct aac gcg ttc ttc atc acc gat cag ggt cgt tct ggt aaa cag   1154
Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln
                370                 375                 380
 
ccg acc ggt caa cag caa tgg ggt gat tgg tgc aac gtt atc ggt act   1202
Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr
            385                 390                 395
 
ggt ttc ggt atc cgt ccg tct gcg aac act ggt gac tct ctg ctg gac   1250
Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp
        400                 405                 410
 
tct ttc gtt tgg gtt aaa cca ggt ggt gaa tgt gac ggt act tct gac   1298
Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp
    415                 420                 425
 
tct tct gct ccg cgc ttc gac tct cac tgt gct ctg cca gac gct ctt   1346
Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu
430                 435                 440                 445
 
caa ccg gct cca cag gct ggc gcg tgg ttt caa gcg tac ttc gtt cag   1394
Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln
                450                 455                 460
 
ctg ctg acc aat gcg aac ccg tct ttc ctg g aattccgatg              1435
Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
            465                 470
 

<210> 12
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in E. coli

<400> 12
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 13
<211> 1441
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (15)...(1427)

<220> 
<223> sequence modified for expression in E. coli

<400> 13
gaatactcca tatg atg atc gtt ggt atc ctg acc acc ctc gcg acc ctg   50
                Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu
                 1               5                   10
 
gct acc ctg gct gct tct gtt ccg ctc gaa gaa cgt cag gct tgt tct   98
Ala Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser
         15                  20                  25
 
tct gtt tgg ggt cag tgc ggt ggc caa aat tgg tct ggt cca acc tgc   146
Ser Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys
     30                  35                  40
 
tgc gct tct ggt tcc acc tgc gtt tac tct aac gac tac tac tct cag   194
Cys Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln
 45                  50                  55                  60
 
tgt ctg cca ggc gcg gcg tcc tct tct tct tct act cgt gcg gct tct   242
Cys Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser
                 65                  70                  75
 
acc acc tct cgt gtg tct ccg acc acc tct cgt tct tct tct gct acc   290
Thr Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr
             80                  85                  90
 
ccg cca cca ggt tct act act act cgc gtt cca ccg gtt ggt tct ggt   338
Pro Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly
         95                 100                 105
 
act gcg acc tac tct ggt aat ccg ttc gtt ggt gtt acc ccg tgg gcg   386
Thr Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala
    110                 115                 120
 
aat gcg tac tat gcg tct gaa gtt agc tct ctc gcg atc ccg tcc ctg   434
Asn Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu
125                 130                 135                 140
 
act ggt gct atg gct act gct gcg gct gcg gtt gcg aaa gtt ccg tct   482
Thr Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser
                145                 150                 155
 
ttc atg tgg ctg gac acc ctg gac aaa acc ccg ctg atg gaa cag acc   530
Phe Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr
            160                 165                 170
 
ctc gcg gac att cgt act gcg aac aaa aac ggt ggc aac tat gcg ggc   578
Leu Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly
        175                 180                 185
 
cag ttt gtt gtt tac gac ctc cca gac cgc gac tgc gct gct ctg gct   626
Gln Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala
    190                 195                 200
 
tct aac ggt gaa tac tct att gcg gac ggt ggt gtt gcg aaa tac aaa   674
Ser Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys
205                 210                 215                 220
 
aac tac atc gat acc atc cgt cag atc gtt gtt gaa tac tct gac atc   722
Asn Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile
                225                 230                 235
 
cgt acc ctg ctg gtt atc gaa ccg gac tct ctg gct aat ctg gtt acc   770
Arg Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr
            240                 245                 250
 
aac ctg ggt act ccg aaa tgc gcg aat gct cag tct gcg tac ctc gaa   818
Asn Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu
        255                 260                 265
 
tgc atc aac tac gcg gtt acc cag ctg aac ctg ccg aac gtt gct atg   866
Cys Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met
    270                 275                 280
 
tac ctg gac gcg ggt cac gct ggt tgg ctg ggt tgg cct gct aat caa   914
Tyr Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln
285                 290                 295                 300
 
gat ccg gct gct cag ctg ttc gca aac gtt tac aaa aat gcg tct tct   962
Asp Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser
                305                 310                 315
 
ccg cgt gcg ctc cgt ggt ctg gct acc aac gtt gcg aac tac aac ggt   1010
Pro Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly
            320                 325                 330
 
tgg aac atc acc tcc ccg ccg tct tac acc caa ggt aac gcg gtt tac   1058
Trp Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr
        335                 340                 345
 
aac gaa aaa ctg tat att cat gcg att ggt cca ctg ctg gct aat cac   1106
Asn Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His
    350                 355                 360
 
ggt tgg tct aac gcg ttc ttc atc acc gat cag ggt cgt tct ggt aaa   1154
Gly Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys
365                 370                 375                 380
 
cag ccg acc ggt caa cag caa tgg ggt gat tgg tgc aac gtt atc ggt   1202
Gln Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly
                385                 390                 395
 
act ggt ttc ggt atc cgt ccg tct gcg aac act ggt gac tct ctg ctg   1250
Thr Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu
            400                 405                 410
 
gac tct ttc gtt tgg gtt aaa cca ggt ggt gaa tgt gac ggt act tct   1298
Asp Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser
        415                 420                 425
 
gac tct tct gct ccg cgc ttc gac tct cac tgt gct ctg cca gac gct   1346
Asp Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala
    430                 435                 440
 
ctt caa ccg gct cca cag gct ggc gcg tgg ttt caa gcg tac ttc gtt   1394
Leu Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val
445                 450                 455                 460
 
cag ctg ctg acc aat gcg aac ccg tct ttc ctg actagtcgat gcct       1441
Gln Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
                465                 470
 

<210> 14
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in E. coli

<400> 14
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 15
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (1)...(1413)

<220> 
<223> sequence modified for expression in P. pastoris

<400> 15
atg att gtt gga att ttg act act tta gct aca ttg gca act tta gca   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt cca tta gaa gag aga cag gct tgt tct tct gtt tgg gga   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt gga gga caa aat tgg tct gga cct aca tgt tgt gct tct gga   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tct act tgt gtt tat tca aat gat tat tat tct caa tgt ttg cca ggt   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gca tct tct tct tct tca aca aga gct gct tca aca aca tca agg   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tca cct act act tct aga tca tct tca gct act cca cca cca gga   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tcg aca act act aga gtg cct ccc gtg gga tca gga aca gca act tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct gga aat cct ttt gtt gga gtg aca cca tgg gca aac gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gct tct gaa gtt tct tca ttg gct att cct tca ttg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct acc gct gct gct gcc gtc gca aaa gtt cct tct ttt atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat act tta gat aaa act cca ttg atg gaa caa act tta gct gac att   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga act gct aat aaa aat gga gga aat tat gct gga caa ttt gtt gtg   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ttg cca gat aga gat tgt gct gct ttg gct tct aat gga gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gct gat gga gga gtt gct aaa tat aaa aat tat att gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
act att aga cag att gtt gtt gaa tat tct gat ata aga aca ttg tta   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt att gaa cca gat tca ttg gct aat ttg gtt act aat ttg gga aca   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cct aaa tgt gct aac gct caa tct gcc tat tta gaa tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gct gtt act caa tta aat ttg cct aat gtg gct atg tat ttg gat gca   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
gga cac gca gga tgg ttg gga tgg cca gca aat caa gat cca gct gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
caa ttg ttt gca aat gtt tat aaa aac gct tct tca cct aga gct ttg   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga gga ttg gct act aat gtt gct aat tat aat gga tgg aat ata act   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tct cca cca tct tat act caa gga aat gca gtt tat aat gaa aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gct att gga cca ttg ttg gct aat cat ggc tgg tct aac   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gct ttc ttt att act gat caa ggt aga tct gga aaa caa cca act ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
cag cag cag tgg gga gat tgg tgt aat gtt att ggt act gga ttc gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
atc aga cca tct gct aat act gga gat tca ttg ttg gat tct ttt gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cct ggt ggt gaa tgt gat ggt act tct gat tct tct gct   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cct aga ttt gat tct cat tgt gct tta cct gat gca tta cag cca gca   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cct caa gcc ggg gca tgg ttc caa gca tat ttt gtt caa ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gca aat cca tca ttt ttg                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 16
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in P. pastoris

<400> 16
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 17
<211> 1435
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (12)...(1425)

<220> 
<223> sequence modified for expression in P. pastoris

<400> 17
tactcaagct t atg att gtt gga att ttg act act tta gct aca ttg gca  50
             Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala
              1               5                   10
 
act tta gca gct tct gtt cca tta gaa gag aga cag gct tgt tct tct   98
Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser
     15                  20                  25
 
gtt tgg gga caa tgt gga gga caa aat tgg tct gga cct aca tgt tgt   146
Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys
 30                  35                  40                  45
 
gct tct gga tct act tgt gtt tat tca aat gat tat tat tct caa tgt   194
Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys
                 50                  55                  60
 
ttg cca ggt gct gca tct tct tct tct tca aca aga gct gct tca aca   242
Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr
             65                  70                  75
 
aca tca agg gtt tca cct act act tct aga tca tct tca gct act cca   290
Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro
         80                  85                  90
 
cca cca gga tcg aca act act aga gtg cct ccc gtg gga tca gga aca   338
Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr
     95                 100                 105
 
gca act tat tct gga aat cct ttt gtt gga gtg aca cca tgg gca aac   386
Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn
110                 115                 120                 125
 
gct tat tat gct tct gaa gtt tct tca ttg gct att cct tca ttg act   434
Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr
                130                 135                 140
 
ggt gct atg gct acc gct gct gct gcc gtc gca aaa gtt cct tct ttt   482
Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe
            145                 150                 155
 
atg tgg ttg gat act tta gat aaa act cca ttg atg gaa caa act tta   530
Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu
        160                 165                 170
 
gct gac att aga act gct aat aaa aat gga gga aat tat gct gga caa   578
Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln
    175                 180                 185
 
ttt gtt gtg tat gat ttg cca gat aga gat tgt gct gct ttg gct tct   626
Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser
190                 195                 200                 205
 
aat gga gaa tat tct att gct gat gga gga gtt gct aaa tat aaa aat   674
Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn
                210                 215                 220
 
tat att gat act att aga cag att gtt gtt gaa tat tct gat ata aga   722
Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg
            225                 230                 235
 
aca ttg tta gtt att gaa cca gat tca ttg gct aat ttg gtt act aat   770
Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn
        240                 245                 250
 
ttg gga aca cct aaa tgt gct aac gct caa tct gcc tat tta gaa tgt   818
Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys
    255                 260                 265
 
att aat tat gct gtt act caa tta aat ttg cct aat gtg gct atg tat   866
Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr
270                 275                 280                 285
 
ttg gat gca gga cac gca gga tgg ttg gga tgg cca gca aat caa gat   914
Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp
                290                 295                 300
 
cca gct gct caa ttg ttt gca aat gtt tat aaa aac gct tct tca cct   962
Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro
            305                 310                 315
 
aga gct ttg aga gga ttg gct act aat gtt gct aat tat aat gga tgg   1010
Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp
        320                 325                 330
 
aat ata act tct cca cca tct tat act caa gga aat gca gtt tat aat   1058
Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn
    335                 340                 345
 
gaa aaa ttg tat att cat gct att gga cca ttg ttg gct aat cat ggc   1106
Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly
350                 355                 360                 365
 
tgg tct aac gct ttc ttt att act gat caa ggt aga tct gga aaa caa   1154
Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln
                370                 375                 380
 
cca act ggt cag cag cag tgg gga gat tgg tgt aat gtt att ggt act   1202
Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr
            385                 390                 395
 
gga ttc gga atc aga cca tct gct aat act gga gat tca ttg ttg gat   1250
Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp
        400                 405                 410
 
tct ttt gtt tgg gtt aaa cct ggt ggt gaa tgt gat ggt act tct gat   1298
Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp
    415                 420                 425
 
tct tct gct cct aga ttt gat tct cat tgt gct tta cct gat gca tta   1346
Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu
430                 435                 440                 445
 
cag cca gca cct caa gcc ggg gca tgg ttc caa gca tat ttt gtt caa   1394
Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln
                450                 455                 460
 
ttg ttg act aat gca aat cca tca ttt ttg g aattccgatg              1435
Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
            465                 470
 

<210> 18
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in P. pastoris

<400> 18
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 19
<211> 1441
<212> DNA
<213> Artificial Sequence

<220> 
<221> CDS            
<222> (15)...(1427)

<220> 
<223> sequence modified for expression in P. pastoris

<400> 19
gaatactcca tatg atg att gtt gga att ttg act act tta gct aca ttg   50
                Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu
                 1               5                   10
 
gca act tta gca gct tct gtt cca tta gaa gag aga cag gct tgt tct   98
Ala Thr Leu Ala Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser
         15                  20                  25
 
tct gtt tgg gga caa tgt gga gga caa aat tgg tct gga cct aca tgt   146
Ser Val Trp Gly Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys
     30                  35                  40
 
tgt gct tct gga tct act tgt gtt tat tca aat gat tat tat tct caa   194
Cys Ala Ser Gly Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln
 45                  50                  55                  60
 
tgt ttg cca ggt gct gca tct tct tct tct tca aca aga gct gct tca   242
Cys Leu Pro Gly Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser
                 65                  70                  75
 
aca aca tca agg gtt tca cct act act tct aga tca tct tca gct act   290
Thr Thr Ser Arg Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr
             80                  85                  90
 
cca cca cca gga tcg aca act act aga gtg cct ccc gtg gga tca gga   338
Pro Pro Pro Gly Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly
         95                 100                 105
 
aca gca act tat tct gga aat cct ttt gtt gga gtg aca cca tgg gca   386
Thr Ala Thr Tyr Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala
    110                 115                 120
 
aac gct tat tat gct tct gaa gtt tct tca ttg gct att cct tca ttg   434
Asn Ala Tyr Tyr Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu
125                 130                 135                 140
 
act ggt gct atg gct acc gct gct gct gcc gtc gca aaa gtt cct tct   482
Thr Gly Ala Met Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser
                145                 150                 155
 
ttt atg tgg ttg gat act tta gat aaa act cca ttg atg gaa caa act   530
Phe Met Trp Leu Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr
            160                 165                 170
 
tta gct gac att aga act gct aat aaa aat gga gga aat tat gct gga   578
Leu Ala Asp Ile Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly
        175                 180                 185
 
caa ttt gtt gtg tat gat ttg cca gat aga gat tgt gct gct ttg gct   626
Gln Phe Val Val Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala
    190                 195                 200
 
tct aat gga gaa tat tct att gct gat gga gga gtt gct aaa tat aaa   674
Ser Asn Gly Glu Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys
205                 210                 215                 220
 
aat tat att gat act att aga cag att gtt gtt gaa tat tct gat ata   722
Asn Tyr Ile Asp Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile
                225                 230                 235
 
aga aca ttg tta gtt att gaa cca gat tca ttg gct aat ttg gtt act   770
Arg Thr Leu Leu Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr
            240                 245                 250
 
aat ttg gga aca cct aaa tgt gct aac gct caa tct gcc tat tta gaa   818
Asn Leu Gly Thr Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu
        255                 260                 265
 
tgt att aat tat gct gtt act caa tta aat ttg cct aat gtg gct atg   866
Cys Ile Asn Tyr Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met
    270                 275                 280
 
tat ttg gat gca gga cac gca gga tgg ttg gga tgg cca gca aat caa   914
Tyr Leu Asp Ala Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln
285                 290                 295                 300
 
gat cca gct gct caa ttg ttt gca aat gtt tat aaa aac gct tct tca   962
Asp Pro Ala Ala Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser
                305                 310                 315
 
cct aga gct ttg aga gga ttg gct act aat gtt gct aat tat aat gga   1010
Pro Arg Ala Leu Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly
            320                 325                 330
 
tgg aat ata act tct cca cca tct tat act caa gga aat gca gtt tat   1058
Trp Asn Ile Thr Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr
        335                 340                 345
 
aat gaa aaa ttg tat att cat gct att gga cca ttg ttg gct aat cat   1106
Asn Glu Lys Leu Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His
    350                 355                 360
 
ggc tgg tct aac gct ttc ttt att act gat caa ggt aga tct gga aaa   1154
Gly Trp Ser Asn Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys
365                 370                 375                 380
 
caa cca act ggt cag cag cag tgg gga gat tgg tgt aat gtt att ggt   1202
Gln Pro Thr Gly Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly
                385                 390                 395
 
act gga ttc gga atc aga cca tct gct aat act gga gat tca ttg ttg   1250
Thr Gly Phe Gly Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu
            400                 405                 410
 
gat tct ttt gtt tgg gtt aaa cct ggt ggt gaa tgt gat ggt act tct   1298
Asp Ser Phe Val Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser
        415                 420                 425
 
gat tct tct gct cct aga ttt gat tct cat tgt gct tta cct gat gca   1346
Asp Ser Ser Ala Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala
    430                 435                 440
 
tta cag cca gca cct caa gcc ggg gca tgg ttc caa gca tat ttt gtt   1394
Leu Gln Pro Ala Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val
445                 450                 455                 460
 
caa ttg ttg act aat gca aat cca tca ttt ttg actagtcgat gcct       1441
Gln Leu Leu Thr Asn Ala Asn Pro Ser Phe Leu
                465                 470
 

<210> 20
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in P. pastoris

<400> 20
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 21
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in K. lactis

<220> 
<221> CDS            
<222> (1)...(1413)

<400> 21
atg att gtt ggt ata ttg act aca ttg gca act tta gct act tta gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct tct gtt cca ttg gaa gaa aga cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
caa tgt ggt ggt caa aat tgg tct ggt cca act tgt tgt gct tct ggt   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tct act tgt gtt tat tct aat gat tat tat tct caa tgt ttg cca ggt   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gca agc tct tct tca tct aca agg gct gca tca act aca agt aga   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tct cct act act tcc agg tct tct tct gct act cca cct cca ggt   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct act act acc aga gtt cca cca gtt ggt tct gga act gct act tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat cca ttc gtt ggt gtt act cca tgg gca aat gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gca agc gaa gtt tct tct tta gct att cca tca ttg act ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct act gct gcg gct gct gtt gct aaa gtt cca tct ttc atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat aca ttg gac aaa act cca ttg atg gaa caa act tta gca gac atc   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga act gct aat aaa aat ggt ggt aat tat gct ggt caa ttc gtt gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ttg ccg gat aga gat tgt gca gct ttg gct tct aat ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gct gat ggc gga gtg gcc aaa tat aaa aat tat att gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
act att aga caa att gtt gtt gaa tat tct gac att aga aca ttg ttg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtt att gaa cca gat tca tta gct aat ttg gtt act aat ttg gga act   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aaa tgt gct aac gcc cag agt gct tac ttg gaa tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gct gtt act caa tta aat ttg cca aat gtt gct atg tat tta gat gct   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
gga cat gct gga tgg ttg ggt tgg cca gct aat caa gac ccg gca gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
cag tta ttc gct aat gtt tat aaa aat gct tct tca cca cgt gca ttg   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga ggt tta gcc aca aac gta gca aat tat aat ggt tgg aat att act   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tct cct cca agc tat act caa ggt aat gct gtt tat aat gaa aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gct att ggt cca ttg ctt gct aat cat ggg tgg tct aat   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcc ttc ttc att act gat caa ggt aga tct ggt aag caa cca aca gga   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
caa caa cag tgg ggt gat tgg tgt aat gtt att gga act ggt ttc gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
att aga cca tct gct aat act ggt gat tct tta ttg gat tct ttc gtt   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa cca gga gga gag tgt gat gga acg tcc gac tct tct gcg   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
ccg aga ttc gat tct cat tgt gct ttg cct gac gca ttg caa ccg gct   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cca caa gcg gga gca tgg ttc cag gct tac ttc gtt caa ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aat gct aat cct tca ttt tta                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 22
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in K. lactis

<400> 22
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     


<210> 23
<211> 1413
<212> DNA
<213> Artificial Sequence

<220> 
<223> sequence modified for expression in Z. mobilis

<220> 
<221> CDS            
<222> (1)...(1413)

<400> 23
atg att gtt ggc att ttg acc acg ttg gcg acg tta gct acc ttg gct   48
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                   10                  15
 
gct agc gtt ccg ttg gaa gaa cgt cag gct tgt tct tct gtt tgg ggt   96
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
             20                  25                  30
 
cag tgt ggt ggt cag aat tgg tct ggt ccg acc tgt tgt gcc tct ggc   144
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
         35                  40                  45
 
tcc acc tgt gtt tat tct aat gat tat tat agc cag tgt ttg cct ggc   192
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
     50                  55                  60
 
gct gcg tcg tct tct agc tct acg cgt gct gct tct acc acc tct cgt   240
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
 65                  70                  75                  80
 
gtt tct ccg acg acc tct cgc agt tct tct gcc acc cca cct cca gga   288
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                 85                  90                  95
 
tct acg acc act aga gtc ccg ccc gtt ggt tct ggt aca gct acg tat   336
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110
 
tct ggt aat ccg ttt gtt ggt gtt acc ccg tgg gct aat gct tat tat   384
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125
 
gct agt gag gtg tct tct ttg gcc att cct agc ttg aca ggt gct atg   432
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140
 
gct aca gcc gct gct gcc gtc gct aaa gtt ccg tct ttt atg tgg ttg   480
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160
 
gat acc ctt gac aaa acc cct tta atg gaa cag acc ctt gcc gac att   528
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175
 
aga acc gct aac aaa aat ggt ggt aat tat gct ggt cag ttt gtt gtt   576
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190
 
tat gat ctt cct gat cgt gat tgt gca gct ctt gcg tct aat ggt gaa   624
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205
 
tat tct att gcc gac ggt ggc gtt gcc aaa tat aaa aat tat atc gat   672
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220
 
acc att cgt cag att gtt gtc gaa tat tct gac att cgt act ctt ttg   720
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240
 
gtc att gaa ccg gat tct ttg gct aac cta gtt acg aac ttg gga acc   768
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255
 
cca aaa tgt gcg aat gcc cag tct gct tat ctg gag tgt att aat tat   816
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270
 
gcc gtt acc cag ttg aat ttg ccg aat gta gcc atg tat ctt gac gct   864
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285
 
gga cat gct gga tgg tta ggt tgg ccc gct aat caa gac cct gct gct   912
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300
 
caa ctt ttt gct aat gtc tat aag aat gcc tct tct cct cgc gct ctt   960
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320
 
aga ggt ttg gct acg aat gtc gca aac tat aac ggt tgg aat att acc   1008
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335
 
tct cct cct agt tat acc cag ggt aat gcc gtc tat aat gag aaa ttg   1056
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350
 
tat att cat gcc att ggt ccg ttg ttg gct aat cat ggt tgg tct aat   1104
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365
 
gcc ttc ttt att acc gat cag ggt cgt tct ggt aaa caa cct acc ggt   1152
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380
 
caa caa cag tgg ggc gac tgg tgt aat gtt ata ggt aca ggt ttt gga   1200
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400
 
atc cgt ccg agt gcc aac aca gga gat agc ttg ctt gac tct ttt gtc   1248
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415
 
tgg gtt aaa ccg ggt ggt gag tgt gat ggc acc tct gat tct tct gca   1296
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430
 
cct cgg ttt gat tct cat tgt gcc ctt ccg gac gcc ctt cag cct gcg   1344
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445
 
cct caa gcg ggt gcc tgg ttt caa gca tat ttc gtt cag ttg ttg act   1392
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460
 
aac gct aat ccg agc ttc ctt                                       1413
Asn Ala Asn Pro Ser Phe Leu
465                 470
 

<210> 24
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> sequence encoded by nucleotide sequence modified
      for expression in Z. mobilis

<400> 24
Met Ile Val Gly Ile Leu Thr Thr Leu Ala Thr Leu Ala Thr Leu Ala
 1               5                  10                  15      
Ala Ser Val Pro Leu Glu Glu Arg Gln Ala Cys Ser Ser Val Trp Gly
            20                  25                  30          
Gln Cys Gly Gly Gln Asn Trp Ser Gly Pro Thr Cys Cys Ala Ser Gly
        35                  40                  45              
Ser Thr Cys Val Tyr Ser Asn Asp Tyr Tyr Ser Gln Cys Leu Pro Gly
    50                  55                  60                  
Ala Ala Ser Ser Ser Ser Ser Thr Arg Ala Ala Ser Thr Thr Ser Arg
65                  70                  75                  80  
Val Ser Pro Thr Thr Ser Arg Ser Ser Ser Ala Thr Pro Pro Pro Gly
                85                  90                  95      
Ser Thr Thr Thr Arg Val Pro Pro Val Gly Ser Gly Thr Ala Thr Tyr
            100                 105                 110         
Ser Gly Asn Pro Phe Val Gly Val Thr Pro Trp Ala Asn Ala Tyr Tyr
        115                 120                 125             
Ala Ser Glu Val Ser Ser Leu Ala Ile Pro Ser Leu Thr Gly Ala Met
    130                 135                 140                 
Ala Thr Ala Ala Ala Ala Val Ala Lys Val Pro Ser Phe Met Trp Leu
145                 150                 155                 160 
Asp Thr Leu Asp Lys Thr Pro Leu Met Glu Gln Thr Leu Ala Asp Ile
                165                 170                 175     
Arg Thr Ala Asn Lys Asn Gly Gly Asn Tyr Ala Gly Gln Phe Val Val
            180                 185                 190         
Tyr Asp Leu Pro Asp Arg Asp Cys Ala Ala Leu Ala Ser Asn Gly Glu
        195                 200                 205             
Tyr Ser Ile Ala Asp Gly Gly Val Ala Lys Tyr Lys Asn Tyr Ile Asp
    210                 215                 220                 
Thr Ile Arg Gln Ile Val Val Glu Tyr Ser Asp Ile Arg Thr Leu Leu
225                 230                 235                 240 
Val Ile Glu Pro Asp Ser Leu Ala Asn Leu Val Thr Asn Leu Gly Thr
                245                 250                 255     
Pro Lys Cys Ala Asn Ala Gln Ser Ala Tyr Leu Glu Cys Ile Asn Tyr
            260                 265                 270         
Ala Val Thr Gln Leu Asn Leu Pro Asn Val Ala Met Tyr Leu Asp Ala
        275                 280                 285             
Gly His Ala Gly Trp Leu Gly Trp Pro Ala Asn Gln Asp Pro Ala Ala
    290                 295                 300                 
Gln Leu Phe Ala Asn Val Tyr Lys Asn Ala Ser Ser Pro Arg Ala Leu
305                 310                 315                 320 
Arg Gly Leu Ala Thr Asn Val Ala Asn Tyr Asn Gly Trp Asn Ile Thr
                325                 330                 335     
Ser Pro Pro Ser Tyr Thr Gln Gly Asn Ala Val Tyr Asn Glu Lys Leu
            340                 345                 350         
Tyr Ile His Ala Ile Gly Pro Leu Leu Ala Asn His Gly Trp Ser Asn
        355                 360                 365             
Ala Phe Phe Ile Thr Asp Gln Gly Arg Ser Gly Lys Gln Pro Thr Gly
    370                 375                 380                 
Gln Gln Gln Trp Gly Asp Trp Cys Asn Val Ile Gly Thr Gly Phe Gly
385                 390                 395                 400 
Ile Arg Pro Ser Ala Asn Thr Gly Asp Ser Leu Leu Asp Ser Phe Val
                405                 410                 415     
Trp Val Lys Pro Gly Gly Glu Cys Asp Gly Thr Ser Asp Ser Ser Ala
            420                 425                 430         
Pro Arg Phe Asp Ser His Cys Ala Leu Pro Asp Ala Leu Gln Pro Ala
        435                 440                 445             
Pro Gln Ala Gly Ala Trp Phe Gln Ala Tyr Phe Val Gln Leu Leu Thr
    450                 455                 460                 
Asn Ala Asn Pro Ser Phe Leu
465                 470     

