                         SEQUENCE LISTING

<110>  MedImmune, LLC
       Coyle, Anthony
       Yao, Yihong
       Jalal, Bahija
       Carlesso, Gianluca
       Bowen, Michael
 
<120>  ANTI-ICOS ANTIBODIES AND THEIR USE IN TREATMENT OF ONCOLOGY, 
       TRANSPLANTATION AND AUTOIMMUNE DISEASE

<130>  IC310PCT

<150>  60/916,400
<151>  2007-05-07

<150>  61/049,131
<151>  2008-04-30

<160>  39    

<170>  PatentIn version 3.3

<210>  1
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  1
gacatccaga tgacccagtc tccatcttcc gtgtctgcat ctgtaggaga cagagtcacc     60

atcacttgtc gggcgagtca gggtattagc aggttgttag cctggtatca gcagaaacca    120

gggaaagccc ctaaactcct gatctatgtt gcatccagtt tgcaaagtgg ggtcccatca    180

aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct    240

gaagattttg caacttacta ttgtcaacag gctaacagtt tcccgtggac gttcggccaa    300

gggaccaagg tggaaatcaa a                                              321


<210>  2
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  2

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Val Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Arg Leu 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Val Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ala Asn Ser Phe Pro Trp 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  3
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Ala Ser Gln Gly Ile Ser Arg Leu Leu Ala 
1               5                   10      


<210>  4
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  4

Val Ala Ser Ser Leu Gln Ser 
1               5           


<210>  5
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  5

Gln Gln Ala Asn Ser Phe Pro Trp Thr 
1               5                   


<210>  6
<211>  376
<212>  DNA
<213>  Homo sapiens

<400>  6
caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc     60

tcctgcaagg cttctggata caccttcacc ggctactata tgcactgggt gcgacaggcc    120

cctggacaag ggcttgagtg gatgggatgg atcaaccctc acagtggtgg cacaaactat    180

gcacagaagt ttcagggcag ggtcaccatg accagggaca cgtccatcag cacagcctac    240

atggagctga gcaggctgag atccgacgac acggccgtgt attactgtgc gaggacgtat    300

tactatgata gtagtggtta ttaccatgat gcttttgata tctggggcca agggacaatg    360

gtcaccgtct cttcag                                                    376


<210>  7
<211>  125
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 
            20                  25                  30          


Tyr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              


Gly Trp Ile Asn Pro His Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  


Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Asp Ala Phe 
            100                 105                 110         


Asp Ile Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 
        115                 120                 125 


<210>  8
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  8

Gly Tyr Tyr Met His 
1               5   


<210>  9
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  9

Trp Ile Asn Pro His Ser Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  10
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr Tyr Tyr Tyr Asp Ser Ser Gly Tyr Tyr His Asp Ala Phe Asp Ile 
1               5                   10                  15      


<210>  11
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  11
tatatatatc tagacatata tatgggtgac aatgacatcc actttgcctt tctctcc        57


<210>  12
<211>  89
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  12
tccactttgc ctttctctcc acaggtgtcc actcccaggt gcagctggtg cagtctgggg     60

ctgaggtgaa gaagcctggg gcctcagtg                                       89


<210>  13
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  13
catatagtag ccggtgaagg tgtatccaga agccttgcag gagaccttca ctgaggcccc     60

aggcttc                                                               67


<210>  14
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  14
caccggctac tatatgcact gggtgcgaca ggcccctgga caagggcttg agtggatggg     60

atggatc                                                               67


<210>  15
<211>  63
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  15
ctgccctgaa acttctgtgc atagtttgtg ccaccactgt gagggttgat ccatcccatc     60

cac                                                                   63


<210>  16
<211>  68
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  16
cagaagtttc agggcagggt caccatgacc agggacacgt ccatcagcac agcctacatg     60

gagctgag                                                              68


<210>  17
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  17
gtcctcgcac agtaatacac ggccgtgtcg tcggatctca gcctgctcag ctccatgtag     60

gctg                                                                  64


<210>  18
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  18
gtattactgt gcgaggacgt attactatga tagtagtggt tattaccatg atgcttttga     60

tatctg                                                                66


<210>  19
<211>  74
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  19
tatatatagg gcccttggtg gaggcctgaa gagacggtga ccattgtccc ttggccccag     60

atatcaaaag catc                                                       74


<210>  20
<211>  79
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  20
tatatatacc ccggggccaa atgtgacatc cagatgaccc agtctccatc ttccgtgtct     60

gcatctgtag gagacagag                                                  79


<210>  21
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  21
gataccaggc taacaacctg ctaataccct gactcgcccg acaagtgatg gtgactctgt     60

ctcctacaga                                                            70


<210>  22
<211>  74
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  22
gttagcctgg tatcagcaga aaccagggaa agcccctaaa ctcctgatct atgttgcatc     60

cagtttgcaa agtg                                                       74


<210>  23
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  23
gtgaaatctg tcccagatcc actgccgctg aaccttgatg ggaccccact ttgcaaactg     60

gatg                                                                  64


<210>  24
<211>  71
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  24
ctgggacaga tttcactctc accatcagca gcctgcagcc tgaagatttt gcaacttact     60

attgtcaaca g                                                          71


<210>  25
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  nucleotide primer

<400>  25
tatatatacg tacgtttgat ttccaccttg gtcccttggc cgaacgtcca cgggaaactg     60

ttagcctgtt gacaatagta ag                                              82


<210>  26
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Asp Asn Asp Ile His Phe Ala Phe Leu Ser Thr Gly Val His 
1               5                   10                  15      


Ser 
    


<210>  27
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  27

Met Asp Met Arg Val Pro Ala Gln Leu Leu Gly Leu Leu Leu Leu Trp 
1               5                   10                  15      


Leu Pro Gly Ala Lys Cys 
            20          


<210>  28
<211>  375
<212>  DNA
<213>  Artificial

<220>
<223>  optimized coding sequence

<400>  28
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ctggcgccag cgtcaaggtg     60

tcctgcaagg ccagcggcta caccttcacc ggctactaca tgcactgggt gcggcaggct    120

ccaggacagg gcctggaatg gatgggctgg atcaaccccc acagcggcgg caccaactac    180

gcccagaagt tccagggcag ggtcaccatg accagggaca ccagcatcag caccgcctac    240

atggaactgt ccaggctgag aagcgacgac accgccgtgt actactgcgc caggacctac    300

tactacgaca gcagcggcta ctaccacgac gccttcgaca tctggggcca gggcaccatg    360

gtgaccgtga gcagc                                                     375


<210>  29
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  optimized coding sequence

<400>  29
gacatccaga tgacccagag ccccagcagc gtgagcgcca gcgtgggcga cagggtgacc     60

atcacctgca gggccagcca gggcatcagc aggctgctgg cctggtatca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacgtg gcctccagcc tccagagcgg cgtgcccagc    180

aggttcagcg gcagcggctc cggcaccgac ttcaccctga ccatcagctc cctgcagccc    240

gaggacttcg ccacctacta ctgccagcag gccaacagct tcccctggac cttcggccag    300

ggcaccaagg tggagatcaa g                                              321


<210>  30
<211>  1368
<212>  DNA
<213>  Artificial

<220>
<223>  optimized coding sequence

<400>  30
caggtgcagc tggtgcagag cggcgctgag gtgaagaagc ctggcgccag cgtcaaggtg     60

tcctgcaagg ccagcggcta caccttcacc ggctactaca tgcactgggt gcggcaggct    120

ccaggacagg gcctggaatg gatgggctgg atcaaccccc acagcggcgg caccaactac    180

gcccagaagt tccagggcag ggtcaccatg accagggaca ccagcatcag caccgcctac    240

atggaactgt ccaggctgag aagcgacgac accgccgtgt actactgcgc caggacctac    300

tactacgaca gcagcggcta ctaccacgac gccttcgaca tctggggcca gggcaccatg    360

gtgaccgtga gcagcgccag caccaagggg cccagcgtgt tccccctggc ccccagcagc    420

aagagcacct ccggcggcac agccgccctg ggctgcctgg tgaaggacta cttccccgaa    480

ccggtgaccg tgtcctggaa cagcggcgct ctgaccagcg gcgtgcacac cttccccgcc    540

gtgctgcaga gcagcggcct gtacagcctg agcagcgtgg tgacagtgcc cagcagcagc    600

ctgggcaccc agacctacat ctgcaacgtg aaccacaagc ccagcaacac caaggtggac    660

aagagagtgg agcccaagag ctgcgacaag acccacacct gccccccctg ccctgcccct    720

gagctgctgg gcggacctag cgtgttcctg ttccccccca agcccaagga caccctgatg    780

atcagcagga cccccgaggt gacctgcgtg gtggtggacg tgagccacga ggaccctgag    840

gtgaagttca attggtacgt ggacggcgtg gaggtgcaca acgccaagac caagcccaga    900

gaggagcagt acaacagcac ctacagggtg gtgtccgtgc tgaccgtgct gcaccaggac    960

tggctgaacg gcaaggaata caagtgcaag gtctccaaca aggccctgcc tgcccccatc   1020

gaaaagacca tcagcaaggc caagggccag cctcgggagc cccaggtgta caccctgccc   1080

cctagccggg aggagatgac caagaaccag gtgtccctga cctgtctggt gaagggcttc   1140

taccccagcg acatcgccgt ggagtgggag agcaacggcc agcccgagaa caactacaag   1200

accacccccc ctgtgctgga cagcgacggc agcttcttcc tgtacagcaa gctgaccgtg   1260

gacaagtcca ggtggcagca gggcaacgtg ttcagctgca gcgtgatgca cgaggccctg   1320

cacaaccact acacccagaa gagcctgagc ctgtcccccg gcaagtaa                1368


<210>  31
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  optimized coding sequence

<400>  31
gacatccaga tgacccagag ccccagcagc gtgagcgcca gcgtgggcga cagggtgacc     60

atcacctgca gggccagcca gggcatcagc aggctgctgg cctggtatca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacgtg gcctccagcc tccagagcgg cgtgcccagc    180

aggttcagcg gcagcggctc cggcaccgac ttcaccctga ccatcagctc cctgcagccc    240

gaggacttcg ccacctacta ctgccagcag gccaacagct tcccctggac cttcggccag    300

ggcaccaagg tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttccccccc    360

agcgacgagc agctgaagag cggcaccgcc tccgtggtgt gcctgctgaa caacttctac    420

ccccgcgagg ccaaggtgca gtggaaggtg gacaacgccc tgcagtccgg caacagccag    480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc    540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gcgaggtgac ccaccagggc    600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gctga                    645


<210>  32
<211>  199
<212>  PRT
<213>  Homo saoiens

<400>  32

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Lys Tyr Ser Ser Ser Val His Asp Pro 
                165                 170                 175     


Asn Gly Glu Tyr Met Phe Met Arg Ala Val Asn Thr Ala Lys Lys Ser 
            180                 185                 190         


Arg Leu Thr Asp Val Thr Leu 
        195                 


<210>  33
<211>  168
<212>  PRT
<213>  Homo saoiens

<400>  33

Met Lys Ser Gly Leu Trp Tyr Phe Phe Leu Phe Cys Leu Arg Ile Lys 
1               5                   10                  15      


Val Leu Thr Gly Glu Ile Asn Gly Ser Ala Asn Tyr Glu Met Phe Ile 
            20                  25                  30          


Phe His Asn Gly Gly Val Gln Ile Leu Cys Lys Tyr Pro Asp Ile Val 
        35                  40                  45              


Gln Gln Phe Lys Met Gln Leu Leu Lys Gly Gly Gln Ile Leu Cys Asp 
    50                  55                  60                  


Leu Thr Lys Thr Lys Gly Ser Gly Asn Thr Val Ser Ile Lys Ser Leu 
65                  70                  75                  80  


Lys Phe Cys His Ser Gln Leu Ser Asn Asn Ser Val Ser Phe Phe Leu 
                85                  90                  95      


Tyr Asn Leu Asp His Ser His Ala Asn Tyr Tyr Phe Cys Asn Leu Ser 
            100                 105                 110         


Ile Phe Asp Pro Pro Pro Phe Lys Val Thr Leu Thr Gly Gly Tyr Leu 
        115                 120                 125             


His Ile Tyr Glu Ser Gln Leu Cys Cys Gln Leu Lys Phe Trp Leu Pro 
    130                 135                 140                 


Ile Gly Cys Ala Ala Phe Val Val Val Cys Ile Leu Gly Cys Ile Leu 
145                 150                 155                 160 


Ile Cys Trp Leu Thr Lys Lys Met 
                165             


<210>  34
<211>  2609
<212>  DNA
<213>  Homo saoiens

<400>  34
ctgaacgcga ggactgttaa ctgtttctgg caaacatgaa gtcaggcctc tggtatttct     60

ttctcttctg cttgcgcatt aaagttttaa caggagaaat caatggttct gccaattatg    120

agatgtttat atttcacaac ggaggtgtac aaattttatg caaatatcct gacattgtcc    180

agcaatttaa aatgcagttg ctgaaagggg ggcaaatact ctgcgatctc actaagacaa    240

aaggaagtgg aaacacagtg tccattaaga gtctgaaatt ctgccattct cagttatcca    300

acaacagtgt ctcttttttt ctatacaact tggaccattc tcatgccaac tattacttct    360

gcaacctatc aatttttgat cctcctcctt ttaaagtaac tcttacagga ggatatttgc    420

atatttatga atcacaactt tgttgccagc tgaagttctg gttacccata ggatgtgcag    480

cctttgttgt agtctgcatt ttgggatgca tacttatttg ttggcttaca aaaaagaagt    540

attcatccag tgtgcacgac cctaacggtg aatacatgtt catgagagca gtgaacacag    600

ccaaaaaatc tagactcaca gatgtgaccc tataatatgg aactctggca cccaggcatg    660

aagcacgttg gccagttttc ctcaacttga agtgcaagat tctcttattt ccgggaccac    720

ggagagtctg acttaactac atacatcttc tgctggtgtt ttgttcaatc tggaagaatg    780

actgtatcag tcaatgggga ttttaacaga ctgccttggt actgccgagt cctctcaaaa    840

caaacaccct cttgcaacca gctttggaga aagcccagct cctgtgtgct cactgggagt    900

ggaatccctg tctccacatc tgctcctagc agtgcatcag ccagtaaaac aaacacattt    960

acaagaaaaa tgttttaaag atgccagggg tactgaatct gcaaagcaaa tgagcagcca   1020

aggaccagca tctgtccgca tttcactatc atactacctc ttctttctgt agggatgaga   1080

attcctcttt taatcagtca agggagatgc ttcaaagctg gagctatttt atttctgaga   1140

tgttgatgtg aactgtacat tagtacatac tcagtactct ccttcaattg ctgaacccca   1200

gttgaccatt ttaccaagac tttagatgct ttcttgtgcc ctcaattttc tttttaaaaa   1260

tacttctaca tgactgcttg acagcccaac agccactctc aatagagagc tatgtcttac   1320

attctttcct ctgctgctca atagttttat atatctatgc atacatatat acacacatat   1380

gtatataaaa ttcataatga atatatttgc ctatattctc cctacaagaa tatttttgct   1440

ccagaaagac atgttctttt ctcaaattca gttaaaatgg tttactttgt tcaagttagt   1500

ggtaggaaac attgcccgga attgaaagca aatttatttt attatcctat tttctaccat   1560

tatctatgtt ttcatggtgc tattaattac aagtttagtt ctttttgtag atcatattaa   1620

aattgcaaac aaaatcatct ttaatgggcc agcattctca tggggtagag cagaatattc   1680

atttagcctg aaagctgcag ttactatagg ttgctgtcag actataccca tggtgcctct   1740

gggcttgaca ggtcaaaatg gtccccatca gcctggagca gccctccaga cctgggtgga   1800

attccagggt tgagagactc ccctgagcca gaggccacta ggtattcttg ctcccagagg   1860

ctgaagtcac cctgggaatc acagtggtct acctgcattc ataattccag gatctgtgaa   1920

gagcacatat gtgtcagggc acaattccct ctcataaaaa ccacacagcc tggaaattgg   1980

ccctggccct tcaagatagc cttctttaga atatgatttg gctagaaaga ttcttaaata   2040

tgtggaatat gattattctt agctggaata ttttctctac ttcctgtctg catgcccaag   2100

gcttctgaag cagccaatgt cgatgcaaca acatttgtaa ctttaggtaa actgggatta   2160

tgttgtagtt taacattttg taactgtgtg cttatagttt acaagtgaga cccgatatgt   2220

cattatgcat acttatatta tcttaagcat gtgtaatgct ggatgtgtac agtacagtac   2280

tgaacttgta atttgaatct agtatggtgt tctgttttca gctgacttgg acaacctgac   2340

tggctttgca caggtgttcc ctgagttgtt tgcaggtttc tgtgtgtggg gtggggtatg   2400

gggaggagaa ccttcatggt ggcccacctg gcctggttgt ccaagctgtg cctcgacaca   2460

tcctcatccc cagcatggga cacctcaaga tgaataataa ttcacaaaat ttctgtgaaa   2520

tcaaatccag ttttaagagg agccacttat caaagagatt ttaacagtag taagaaggca   2580

aagaataaac atttgatatt cagcaactg                                     2609


<210>  35
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  35
aguuguuuua gugacuacga ccu                                             23


<210>  36
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  36
aguaucggga cauguuacga cga                                             23


<210>  37
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  37
acuaucggga cauguuacga cga                                             23


<210>  38
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  38
gaagucaaua gugucaugac au                                              22


<210>  39
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  39
ccucacuucu gugccucggu cu                                              22


