                         SEQUENCE LISTING

<110>  Sloan Kettering Memorial Cancer Center
       Sloan Kettering Institute for Cancer Research
 
<120>  METHODS FOR TREATING AND PREVENTING GI SYNDROME AND GRAFT VERSUS 
       HOST DISEASE

<130>  SKC001007PCT

<150>  60/916,007
<151>  2007-05-06

<160>  9     

<170>  PatentIn version 3.5

<210>  1
<211>  631
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Arg Tyr Gly Ala Ser Leu Arg Gln Ser Cys Pro Arg Ser Gly 
1               5                   10                  15      


Arg Glu Gln Gly Gln Asp Gly Thr Ala Gly Ala Pro Gly Leu Leu Trp 
            20                  25                  30          


Met Gly Leu Val Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala Leu Ala 
        35                  40                  45              


Leu Ser Asp Ser Arg Val Leu Trp Ala Pro Ala Glu Ala His Pro Leu 
    50                  55                  60                  


Ser Pro Gln Gly His Pro Ala Arg Leu His Arg Ile Val Pro Arg Leu 
65                  70                  75                  80  


Arg Asp Val Phe Gly Trp Gly Asn Leu Thr Cys Pro Ile Cys Lys Gly 
                85                  90                  95      


Leu Phe Thr Ala Ile Asn Leu Gly Leu Lys Lys Glu Pro Asn Val Ala 
            100                 105                 110         


Arg Val Gly Ser Val Ala Ile Lys Leu Cys Asn Leu Leu Lys Ile Ala 
        115                 120                 125             


Pro Pro Ala Val Cys Gln Ser Ile Val His Leu Phe Glu Asp Asp Met 
    130                 135                 140                 


Val Glu Val Trp Arg Arg Ser Val Leu Ser Pro Ser Glu Ala Cys Gly 
145                 150                 155                 160 


Leu Leu Leu Gly Ser Thr Cys Gly His Trp Asp Ile Phe Ser Ser Trp 
                165                 170                 175     


Asn Ile Ser Leu Pro Thr Val Pro Lys Pro Pro Pro Lys Pro Pro Ser 
            180                 185                 190         


Pro Pro Ala Pro Gly Ala Pro Val Ser Arg Ile Leu Phe Leu Thr Asp 
        195                 200                 205             


Leu His Trp Asp His Asp Tyr Leu Glu Gly Thr Asp Pro Asp Cys Ala 
    210                 215                 220                 


Asp Pro Leu Cys Cys Arg Arg Gly Ser Gly Leu Pro Pro Ala Ser Arg 
225                 230                 235                 240 


Pro Gly Ala Gly Tyr Trp Gly Glu Tyr Ser Lys Cys Asp Leu Pro Leu 
                245                 250                 255     


Arg Thr Leu Glu Ser Leu Leu Ser Gly Leu Gly Pro Ala Gly Pro Phe 
            260                 265                 270         


Asp Met Val Tyr Trp Thr Gly Asp Ile Pro Ala His Asp Val Trp His 
        275                 280                 285             


Gln Thr Arg Gln Asp Gln Leu Arg Ala Leu Thr Thr Val Thr Ala Leu 
    290                 295                 300                 


Val Arg Lys Phe Leu Gly Pro Val Pro Val Tyr Pro Ala Val Gly Asn 
305                 310                 315                 320 


His Glu Ser Thr Pro Val Asn Ser Phe Pro Pro Pro Phe Ile Glu Gly 
                325                 330                 335     


Asn His Ser Ser Arg Trp Leu Tyr Glu Ala Met Ala Lys Ala Trp Glu 
            340                 345                 350         


Pro Trp Leu Pro Ala Glu Ala Leu Arg Thr Leu Arg Ile Gly Gly Phe 
        355                 360                 365             


Tyr Ala Leu Ser Pro Tyr Pro Gly Leu Arg Leu Ile Ser Leu Asn Met 
    370                 375                 380                 


Asn Phe Cys Ser Arg Glu Asn Phe Trp Leu Leu Ile Asn Ser Thr Asp 
385                 390                 395                 400 


Pro Ala Gly Gln Leu Gln Trp Leu Val Gly Glu Leu Gln Ala Ala Glu 
                405                 410                 415     


Asp Arg Gly Asp Lys Val His Ile Ile Gly His Ile Pro Pro Gly His 
            420                 425                 430         


Cys Leu Lys Ser Trp Ser Trp Asn Tyr Tyr Arg Ile Val Ala Arg Tyr 
        435                 440                 445             


Glu Asn Thr Leu Ala Ala Gln Phe Phe Gly His Thr His Val Asp Glu 
    450                 455                 460                 


Phe Glu Val Phe Tyr Asp Glu Glu Thr Leu Ser Arg Pro Leu Ala Val 
465                 470                 475                 480 


Ala Phe Leu Ala Pro Ser Ala Thr Thr Tyr Ile Gly Leu Asn Pro Gly 
                485                 490                 495     


Tyr Arg Val Tyr Gln Ile Asp Gly Asn Tyr Ser Gly Ser Ser His Val 
            500                 505                 510         


Val Leu Asp His Glu Thr Tyr Ile Leu Asn Leu Thr Gln Ala Asn Ile 
        515                 520                 525             


Pro Gly Ala Ile Pro His Trp Gln Leu Leu Tyr Arg Ala Arg Glu Thr 
    530                 535                 540                 


Tyr Gly Leu Pro Asn Thr Leu Pro Thr Ala Trp His Asn Leu Val Tyr 
545                 550                 555                 560 


Arg Met Arg Gly Asp Met Gln Leu Phe Gln Thr Phe Trp Phe Leu Tyr 
                565                 570                 575     


His Lys Gly His Pro Pro Ser Glu Pro Cys Gly Thr Pro Cys Arg Leu 
            580                 585                 590         


Ala Thr Leu Cys Ala Gln Leu Ser Ala Arg Ala Asp Ser Pro Ala Leu 
        595                 600                 605             


Cys Arg His Leu Met Pro Asp Gly Ser Leu Pro Glu Ala Gln Ser Leu 
    610                 615                 620                 


Trp Pro Arg Pro Leu Phe Cys 
625                 630     


<210>  2
<211>  2473
<212>  DNA
<213>  Homo sapiens

<400>  2
atcagaggaa gaggaagggg cggagctgct ttgcggccgg ccgcggagca gtcagccgac       60

tacagagaag ggtaatcggg tgtccccggc gccgcccggg gccctgaggg ctggctaggg      120

tccaggccgg gggggacggg acagacgaac cagccccgtg taggaagcgc gacaatgccc      180

cgctacggag cgtcactccg ccagagctgc cccaggtccg gccgggagca gggacaagac      240

gggaccgccg gagcccccgg actcctttgg atgggcctgg tgctggcgct ggcgctggcg      300

ctggcgctgg cgctggctct gtctgactct cgggttctct gggctccggc agaggctcac      360

cctctttctc cccaaggcca tcctgccagg ttacatcgca tagtgccccg gctccgagat      420

gtctttgggt gggggaacct cacctgccca atctgcaaag gtctattcac cgccatcaac      480

ctcgggctga agaaggaacc caatgtggct cgcgtgggct ccgtggccat caagctgtgc      540

aatctgctga agatagcacc acctgccgtg tgccaatcca ttgtccacct ctttgaggat      600

gacatggtgg aggtgtggag acgctcagtg ctgagcccat ctgaggcctg tggcctgctc      660

ctgggctcca cctgtgggca ctgggacatt ttctcatctt ggaacatctc tttgcctact      720

gtgccgaagc cgccccccaa accccctagc cccccagccc caggtgcccc tgtcagccgc      780

atcctcttcc tcactgacct gcactgggat catgactacc tggagggcac ggaccctgac      840

tgtgcagacc cactgtgctg ccgccggggt tctggcctgc cgcccgcatc ccggccaggt      900

gccggatact ggggcgaata cagcaagtgt gacctgcccc tgaggaccct ggagagcctg      960

ttgagtgggc tgggcccagc cggccctttt gatatggtgt actggacagg agacatcccc     1020

gcacatgatg tctggcacca gactcgtcag gaccaactgc gggccctgac caccgtcaca     1080

gcacttgtga ggaagttcct ggggccagtg ccagtgtacc ctgctgtggg taaccatgaa     1140

agcacacctg tcaatagctt ccctcccccc ttcattgagg gcaaccactc ctcccgctgg     1200

ctctatgaag cgatggccaa ggcttgggag ccctggctgc ctgccgaagc cctgcgcacc     1260

ctcagaattg gggggttcta tgctctttcc ccataccccg gtctccgcct catctctctc     1320

aatatgaatt tttgttcccg tgagaacttc tggctcttga tcaactccac ggatcccgca     1380

ggacagctcc agtggctggt gggggagctt caggctgctg aggatcgagg agacaaagtg     1440

catataattg gccacattcc cccagggcac tgtctgaaga gctggagctg gaattattac     1500

cgaattgtag ccaggtatga gaacaccctg gctgctcagt tctttggcca cactcatgtg     1560

gatgaatttg aggtcttcta tgatgaagag actctgagcc ggccgctggc tgtagccttc     1620

ctggcaccca gtgcaactac ctacatcggc cttaatcctg gttaccgtgt gtaccaaata     1680

gatggaaact actccgggag ctctcacgtg gtcctggacc atgagaccta catcctgaat     1740

ctgacccagg caaacatacc gggagccata ccgcactggc agcttctcta cagggctcga     1800

gaaacctatg ggctgcccaa cacactgcct accgcctggc acaacctggt atatcgcatg     1860

cggggcgaca tgcaactttt ccagaccttc tggtttctct accataaggg ccacccaccc     1920

tcggagccct gtggcacgcc ctgccgtctg gctactcttt gtgcccagct ctctgcccgt     1980

gctgacagcc ctgctctgtg ccgccacctg atgccagatg ggagcctccc agaggcccag     2040

agcctgtggc caaggccact gttttgctag ggccccaggg cccacatttg ggaaagttct     2100

tgatgtagga aagggtgaaa aagcccaaat gctgctgtgg ttcaaccagg caagatcatc     2160

cggtgaaaga accagtccct gggccccaag gatgccgggg aaacaggacc ttctcctttc     2220

ctggagctgg tttagctgga tatgggaggg ggtttggctg cctgtgccca ggagctagac     2280

tgccttgagg ctgctgtcct ttcacagcca tggagtagag gcctaagttg acactgccct     2340

gggcagacaa gacaggagct gtcgccccag gcctgtgctg cccagccagg aaccctgtac     2400

tgctgctgcg acctgatgct gccagtctgt taaaataaag ataagagact tggactccaa     2460

aaaaaaaaaa aaa                                                        2473


<210>  3
<211>  192
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Gly Ser Gly Glu Gln Pro Arg Gly Gly Gly Pro Thr Ser Ser 
1               5                   10                  15      


Glu Gln Ile Met Lys Thr Gly Ala Leu Leu Leu Gln Gly Phe Ile Gln 
            20                  25                  30          


Asp Arg Ala Gly Arg Met Gly Gly Glu Ala Pro Glu Leu Ala Leu Asp 
        35                  40                  45              


Pro Val Pro Gln Asp Ala Ser Thr Lys Lys Leu Ser Glu Cys Leu Lys 
    50                  55                  60                  


Arg Ile Gly Asp Glu Leu Asp Ser Asn Met Glu Leu Gln Arg Met Ile 
65                  70                  75                  80  


Ala Ala Val Asp Thr Asp Ser Pro Arg Glu Val Phe Phe Arg Val Ala 
                85                  90                  95      


Ala Asp Met Phe Ser Asp Gly Asn Phe Asn Trp Gly Arg Val Val Ala 
            100                 105                 110         


Leu Phe Tyr Phe Ala Ser Lys Leu Val Leu Lys Ala Leu Cys Thr Lys 
        115                 120                 125             


Val Pro Glu Leu Ile Arg Thr Ile Met Gly Trp Thr Leu Asp Phe Leu 
    130                 135                 140                 


Arg Glu Arg Leu Leu Gly Trp Ile Gln Asp Gln Gly Gly Trp Asp Gly 
145                 150                 155                 160 


Leu Leu Ser Tyr Phe Gly Thr Pro Thr Trp Gln Thr Val Thr Ile Phe 
                165                 170                 175     


Val Ala Gly Val Leu Thr Ala Ser Leu Thr Ile Trp Lys Lys Met Gly 
            180                 185                 190         


<210>  4
<211>  888
<212>  DNA
<213>  Homo sapiens

<400>  4
tcacgtgacc cgggcgcgct gcggccgccc gcgcggaccc ggcgagaggc ggcggcggga       60

gcggcggtga tggacgggtc cggggagcag cccagaggcg gggggcccac cagctctgag      120

cagatcatga agacaggggc ccttttgctt cagggtttca tccaggatcg agcagggcga      180

atgggggggg aggcacccga gctggccctg gacccggtgc ctcaggatgc gtccaccaag      240

aagctgagcg agtgtctcaa gcgcatcggg gacgaactgg acagtaacat ggagctgcag      300

aggatgattg ccgccgtgga cacagactcc ccccgagagg tctttttccg agtggcagct      360

gacatgtttt ctgacggcaa cttcaactgg ggccgggttg tcgccctttt ctactttgcc      420

agcaaactgg tgctcaaggc cctgtgcacc aaggtgccgg aactgatcag aaccatcatg      480

ggctggacat tggacttcct ccgggagcgg ctgttgggct ggatccaaga ccagggtggt      540

tgggacggcc tcctctccta ctttgggacg cccacgtggc agaccgtgac catctttgtg      600

gcgggagtgc tcaccgcctc actcaccatc tggaagaaga tgggctgagg cccccagctg      660

ccttggactg tgtttttcct ccataaatta tggcattttt ctgggagggg tggggattgg      720

gggacgtggg catttttctt acttttgtaa ttattggggg gtgtggggaa gagtggtctt      780

gagggggtaa taaacctcct tcgggacaca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa      840

aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa                   888


<210>  5
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Ser Gly Gln Gly Pro Gly Pro Pro Arg Gln Glu Cys Gly Glu 
1               5                   10                  15      


Pro Ala Leu Pro Ser Ala Ser Glu Glu Gln Val Ala Gln Asp Thr Glu 
            20                  25                  30          


Glu Val Phe Arg Ser Tyr Val Phe Tyr Arg His Gln Gln Glu Gln Glu 
        35                  40                  45              


Ala Glu Gly Val Ala Ala Pro Ala Asp Pro Glu Met Val Thr Leu Pro 
    50                  55                  60                  


Leu Gln Pro Ser Ser Thr Met Gly Gln Val Gly Arg Gln Leu Ala Ile 
65                  70                  75                  80  


Ile Gly Asp Asp Ile Asn Arg Arg Tyr Asp Ser Glu Phe Gln Thr Met 
                85                  90                  95      


Leu Gln His Leu Gln Pro Thr Ala Glu Asn Ala Tyr Glu Tyr Phe Thr 
            100                 105                 110         


Lys Ile Ala Thr Ser Leu Phe Glu Ser Gly Ile Asn Trp Gly Arg Val 
        115                 120                 125             


Val Ala Leu Leu Gly Phe Gly Tyr Arg Leu Ala Leu His Val Tyr Gln 
    130                 135                 140                 


His Gly Leu Thr Gly Phe Leu Gly Gln Val Thr Arg Phe Val Val Asp 
145                 150                 155                 160 


Phe Met Leu His His Cys Ile Ala Arg Trp Ile Ala Gln Arg Gly Gly 
                165                 170                 175     


Trp Val Ala Ala Leu Asn Leu Gly Asn Gly Pro Ile Leu Asn Val Leu 
            180                 185                 190         


Val Val Leu Gly Val Val Leu Leu Gly Gln Phe Val Val Arg Arg Phe 
        195                 200                 205             


Phe Lys Ser 
    210     


<210>  6
<211>  2203
<212>  DNA
<213>  Homo sapiens

<400>  6
gtctgcatcc ggtggccaca gagcaacttc ctctagaggg agctgattgg agccgggtgc       60

cgctggcacc tctatgatca ctggagtctc gcgggtccct cgggctgcac agggacaagt      120

aaaggctaca tccagatgcc gggaatgcac tgacgcccat tcctggaaac tgggctccca      180

ctcagcccct gggagcagca gccgccagcc cctcgggacc tccatctcca ccctgctgag      240

ccacccgggt tgggccagga tcccggcagg ctgatcccgt cctccactga gacctgaaaa      300

atggcttcgg ggcaaggccc aggtcctccc aggcaggagt gcggagagcc tgccctgccc      360

tctgcttctg aggagcaggt agcccaggac acagaggagg ttttccgcag ctacgttttt      420

taccgccatc agcaggaaca ggaggctgaa ggggtggctg cccctgccga cccagagatg      480

gtcaccttac ctctgcaacc tagcagcacc atggggcagg tgggacggca gctcgccatc      540

atcggggacg acatcaaccg acgctatgac tcagagttcc agaccatgtt gcagcacctg      600

cagcccacgg cagagaatgc ctatgagtac ttcaccaaga ttgccaccag cctgtttgag      660

agtggcatca attggggccg tgtggtggct cttctgggct tcggctaccg tctggcccta      720

cacgtctacc agcatggcct gactggcttc ctaggccagg tgacccgctt cgtggtcgac      780

ttcatgctgc atcactgcat tgcccggtgg attgcacaga ggggtggctg ggtggcagcc      840

ctgaacttgg gcaatggtcc catcctgaac gtgctggtgg ttctgggtgt ggttctgttg      900

ggccagtttg tggtacgaag attcttcaaa tcatgactcc caagggtgcc ctttggggtc      960

ccggttcaga cccctgcctg gacttaagcg aagtctttgc cttctctgtt cccttgcagg     1020

ggtcccccct caagagtaca gaagctttag caagtgtgca ctccagcttc ggagggcccc     1080

tgcgtggggg ccagtcaggc tgcagaggca cctcaacatt gcatggtgct agtgggccct     1140

ctctctgggc ccaggggctg tggccgtctc ctccctcagc tctctgggac ctccttagcc     1200

ctgtctgcta ggcgctgggg agactgataa cttggggagg caagagactg ggagccactt     1260

ctccccagaa agtgtttaac ggttttagct ttttataata cccttgtgag agcccattcc     1320

caccattcta cctgaggcca ggacgtctgg ggtgtgggga ttggtgggtc tatgttcccc     1380

aggattcagc tattctggaa gatcagcacc ctaagagatg ggactaggac ctgagcctgg     1440

tcctggccgt ccctaagcat gtgtcccagg agcaggacct actaggagag gggggccaag     1500

gtcctgctca actctacccc tgctcccatt cctccctccg gccatactgc ctttgcagtt     1560

ggactctcag ggattctggg cttggggtgt ggggtggggt ggagtcgcag accagagctg     1620

tctgaactca cgtgtcagaa gcctccaagc ctgcctccca aggtcctctc agttctctcc     1680

cttcctctct ccttatagac acttgctccc aacccattca ctacaggtga aggctctcac     1740

ccccatccct gggggccttg ggtgagtggc ctgctaaggc tcctccttgc ccagactaca     1800

gggcttagga cttggtttgt tatatcaggg aaaaggagta gggagttcat ctggagggtt     1860

ctaagtggga gaaggactat caacaccact aggaatccca gaggtgggat cctccctcat     1920

ggctctggca cagtgtaatc caggggtgta gatgggggaa ctgtgaatac ttgaactctg     1980

ttcccccacc ctccatgctc ctcacctgtc taggtctcct cagggtgggg ggtgacagtg     2040

ccttctctat tgggcacagc ctagggtctt gggggtcagg ggggagaagt tcttgattca     2100

gccaaatgca gggaggggag gcagatggag cccataggcc accccctatc ctctgagtgt     2160

ttggaaataa actgtgcaat cccctcaccc tgaaaaaaaa aaa                       2203


<210>  7
<211>  4572
<212>  DNA
<213>  Homo sapiens

<400>  7
atcagaggaa gaggaagggg cggagctgct ttgcggccgg ccgcggagca gtcagccgac       60

tacagagaag ggtaatcggg tgtccccggc gccgcccggg gccctgaggg ctggctaggg      120

tccaggccgg gggggacggg acagacgaac cagccccgtg taggaagcgc gacaatgccc      180

cgctacggag cgtcactccg ccagagctgc cccaggtccg gccgggagca gggacaagac      240

gggaccgccg gagcccccgg actcctttgg atgggcctgg tgctggcgct ggcgctggcg      300

ctggcgctgg cgctggctct gtctgactct cgggttctct gggctccggc agaggctcac      360

cctctttctc cccaaggcca tcctgccagg ttacatcgca tagtgccccg gctccgagat      420

gtctttgggt gggggaacct cacctgccca atctgcaaag gtctattcac cgccatcaac      480

ctcgggctga aggtgagcac tgaaggggct gcagtggagg aggccgaaag gagtgctggg      540

gctgggggct ggggctgatg ctggtgcgct gggctcagaa tgcatccctg atggagaggg      600

tggcatctac aatccatcac tgagtttgct cccctttggg gacacccatg gctacatgcc      660

accatcaccc cattgtgacc tttgtgaagt aagaaaataa tgcagacagt gcctgaggaa      720

gtcagcttgc caagcaaagg cctcatgcca caggccgctg agctaaagaa gaagcgatgg      780

cctggtgctg cctgagttac agggcaatat ctggaaggca aaggtgtgca ctgagcttgg      840

tgcactgagt cctgcccagc cccagtttgg aaatggaggc ccaaggggtg gtggccaggg      900

gttggcctgg ttcctctgct ctgcctctga tttctcacca tgcgctcctc ccactgcaga      960

aggaacccaa tgtggctcgc gtgggctccg tggccatcaa gctgtgcaat ctgctgaaga     1020

tagcaccacc tgccgtgtgc caatccattg tccacctctt tgaggatgac atggtggagg     1080

tgtggagacg ctcagtgctg agcccatctg aggcctgtgg cctgctcctg ggctccacct     1140

gtgggcactg ggacattttc tcatcttgga acatctcttt gcctactgtg ccgaagccgc     1200

cccccaaacc ccctagcccc ccagccccag gtgcccctgt cagccgcatc ctcttcctca     1260

ctgacctgca ctgggatcat gactacctgg agggcacgga ccctgactgt gcagacccac     1320

tgtgctgccg ccggggttct ggcctgccgc ccgcatcccg gccaggtgcc ggatactggg     1380

gcgaatacag caagtgtgac ctgcccctga ggaccctgga gagcctgttg agtgggctgg     1440

gcccagccgg cccttttgat atggtgtact ggacaggaga catccccgca catgatgtct     1500

ggcaccagac tcgtcaggac caactgcggg ccctgaccac cgtcacagca cttgtgagga     1560

agttcctggg gccagtgcca gtgtaccctg ctgtgggtaa ccatgaaagc acacctgtca     1620

atagcttccc tccccccttc attgagggca accactcctc ccgctggctc tatgaagcga     1680

tggccaaggc ttgggagccc tggctgcctg ccgaagccct gcgcaccctc aggtacttat     1740

cgtccgtgga aacccaggaa gggaaaagaa aggtgaatga aagtgaaggg agaagggaac     1800

ctggggcatt gtctctgatt gctctagcat gagtccttag tgctcttcat ttggctcccc     1860

taatctgact cctccttccc tttctactgt tttgccgcac caggcttttt tttttttttt     1920

ttttttagtt tagtttttgt agagacaaga tcttgctatg ttgcccaggc tggtctcaaa     1980

cacctaacct caagcaatcc tcccgcctcg gcctcccaaa atgctgggac cacaggcatc     2040

agctactgct cctggccctc cctttttttt tttttttttt tttttttttt tgagatggaa     2100

tcttgctctg ttgcccaggc tggagtgcag tggcaccatc tcagctcact acagcctcca     2160

cctcctgggt tcaagcaatt ctgcctcagc ctcccaagta cctgggacta caggtgcacg     2220

ccaccacacc cagctaattt ttgtattttt agtagagatg gggtttcacc atgttggcca     2280

agatggtctt gatctcctga cctcatgatc tgcccacctc ggcctcccaa agtgctggga     2340

ttacaggcat gaaccactgc acccagcttt ccagccctcc ctttctactc ttatctccag     2400

ccaccctcct tcaaaggtct ggcagcataa cctctctatg ccccagctgt gtctttgctc     2460

atgttggccc tctggaaatg atttccccct tttttttaag tgctccagtt tttcccacct     2520

tatccatccc atgtcatctt ccctctgtgt ggtccttgct tcccattcta gctaactctt     2580

atccctcccc catactcctg gagccctctg ccctcagagt cttttgtgtc acacagaccc     2640

aataattaga actgtttggt ctctggctag actgtgagct ccttgcaggt ggggaagatg     2700

tcatgtatgc ttttaccctc cacccaaatg cccagcacag gaggaccagg attggaacaa     2760

gtgttgacct ctcatgttta ctttgtttca gaattggggg gttctatgct ctttccccat     2820

accccggtct ccgcctcatc tctctcaata tgaatttttg ttcccgtgag aacttctggc     2880

tcttgatcaa ctccacggat cccgcaggac agctccagtg gctggtgggg gagcttcagg     2940

ctgctgagga tcgaggagac aaagtgaggg ccagtagtgg gaacacggtg gtgctggggg     3000

acaagcaggc tcctgttgag ctggagcacc tctgggcaca gaagttttat tttcctggca     3060

ttcccaacaa gtgttccctg gggattcagc tcatggtcac tgttgaaagc cttcattcag     3120

tccccctttc tctagccagg gctgcctgga cccctggatg ccctgattac catccttaat     3180

tctccctact aggtgcatat aattggccac attcccccag ggcactgtct gaagagctgg     3240

agctggaatt attaccgaat tgtagccagg taggacggag atgagggtgg gaatagggac     3300

agggtgagtg tctgaaggct gaaaattccc ttgagcatct caccatccct gttgtcccat     3360

ggagtgggga ggctcctcac tagaacaggt tggagaaaga gggcatccta tctccccaga     3420

tgtcttccta cccctcccta gaatcttctg aatgtagtac cttctggcca ggtatgagaa     3480

caccctggct gctcagttct ttggccacac tcatgtggat gaatttgagg tcttctatga     3540

tgaagagact ctgagccggc cgctggctgt agccttcctg gcacccagtg caactaccta     3600

catcggcctt aatcctggtg agtgaggcag aagggagcct cccttatcct ggagttggtg     3660

ggatagggga aggaggttgg agccagagcc tgcaaagcat gggcaggatg tgtggcccct     3720

ccctggagtt acccttgctc cttgcccctc cagtcagccc cacatccttg caggttaccg     3780

tgtgtaccaa atagatggaa actactccgg gagctctcac gtggtcctgg accatgagac     3840

ctacatcctg aatctgaccc aggcaaacat accgggagcc ataccgcact ggcagcttct     3900

ctacagggct cgagaaacct atgggctgcc caacacactg cctaccgcct ggcacaacct     3960

ggtatatcgc atgcggggcg acatgcaact tttccagacc ttctggtttc tctaccataa     4020

gggccaccca ccctcggagc cctgtggcac gccctgccgt ctggctactc tttgtgccca     4080

gctctctgcc cgtgctgaca gccctgctct gtgccgccac ctgatgccag atgggagcct     4140

cccagaggcc cagagcctgt ggccaaggcc actgttttgc tagggcccca gggcccacat     4200

ttgggaaagt tcttgatgta ggaaagggtg aaaaagccca aatgctgctg tggttcaacc     4260

aggcaagatc atccggtgaa agaaccagtc cctgggcccc aaggatgccg gggaaacagg     4320

accttctcct ttcctggagc tggtttagct ggatatggga gggggtttgg ctgcctgtgc     4380

ccaggagcta gactgccttg aggctgctgt cctttcacag ccatggagta gaggcctaag     4440

ttgacactgc cctgggcaga caagacagga gctgtcgccc caggcctgtg ctgcccagcc     4500

aggaaccctg tactgctgct gcgacctgat gctgccagtc tgttaaaata aagataagag     4560

acttggactc ca                                                         4572


<210>  8
<211>  6939
<212>  DNA
<213>  Homo sapiens

<400>  8
tcacgtgacc cgggcgcgct gcggccgccc gcgcggaccc ggcgagaggc ggcggcggga       60

gcggcggtga tggacgggtc cggggagcag cccagaggcg ggggtgaggc gggaggcaga      120

cgggcgggag gagggcgagc cccctcgccg gcccgtccgg gatccttcct accggcctgg      180

ggctgtgcga tctccaagca ctgaggggca gaaactcccg gatcgggcgc tgccagcctc      240

cagtcccctc cgtcctcgga ggttcctggc tctctgatcc ccgtgtcccg atccctgcct      300

ctctggcgct ctcggaccct cgagaaccag gggatctcgg aagccaagcc cccgggcagg      360

cccgggcttg tcgcccgcac cacttcctgc ctctggcact ggtgggaggg gcgggtctcg      420

cctctgcccc ctcaggccag gggtctggat gcatatagcg ttcccctagc ctctttcccc      480

ggggagaatg taggatacag gcccagcctc ctggcctttc tccatcaggg actcagttgt      540

ctgggccccc ccgtcacttt atctgctagg gtcccagaag tccagggtcc ccagctctgt      600

cctccctcag gggccgtgag tctccacagt ctcctgatcc cctagaaccc aagagtccag      660

gtacctcttc ccttcctttc tcctctaggg cccaccagct ctgagcagat catgaagaca      720

ggggcccttt tgcttcaggg gtgagtttga ggtctgatta ttgtggcaca gatttgagga      780

gtgacacccc gttctgattc tgcaccctca ctccatcccc actctagttt catccaggat      840

cgagcagggc gaatgggggg ggaggcaccc gagctggccc tggacccggt gcctcaggat      900

gcgtccacca agaagctgag cgagtgtctc aagcgcatcg gggacgaact ggacagtaac      960

atggagctgc agaggtgtgg gcccctgagg acccagaagt ccagccactg ggctccttca     1020

ggacacagga ctctcagccc cgcattctcc tcctccccta agaactagga gtctgggccc     1080

cacaactcag cgcaaacatt ccggactccc agccctcctc tctgccagga tcttaaaacc     1140

ctccttcagg gagtcatttt tcccaccttc ctaaatgtct gtcttgtccc cttcccttgt     1200

cccccgttgg cctgttgctt ttcatttcag cctggcttgg ggctcagtct ccttatcttt     1260

agtgtgcggt ggatgcggga attttccacc atcagcctga tgcctgctcc ccggcactgg     1320

ttctcctctc tcctgcagga tgattgccgc cgtggacaca gactcccccc gagaggtctt     1380

tttccgagtg gcagctgaca tgttttctga cggcaacttc aactggggcc gggttgtcgc     1440

ccttttctac tttgccagca aactggtgct caaggtgggc agctgcaggg cagtgagccc     1500

agggatgctc cccctcagat ctgtgaggac ctggggatcg tggtatcaac cccctgcagt     1560

ggcccagtga ccacagaggg catggagaga gatggctgtg cactgggtgt ctgctccttc     1620

ttttattcat tcaacaagca tttactggac ctgctatgtg ccaggcctat acctggcacc     1680

tgggacacag cactgtacaa agcaggctac atccctgctc tcagggagtt cacgtgcagg     1740

ggtgaagtaa agtgggcagt gtgatttagc agagtggtca ggaaagattt ctattttttt     1800

tttttttttt tttgagatgg agttttgctc ttgttgccca ggcttgagtg caatggcatg     1860

atcttggttc actgcaacct ctgcctccca ggttcaagcg attctcctgc ctcagcttcc     1920

tgagtagctg ggattatggg tgtgcaccat tatccctggc tttttttttt tttttttttt     1980

tttttgtatt tttagtagag acgggtttca ccatgttggt caggctggtc ttgaactcct     2040

gacctcaagt gatccacctg ccttggcctc ccaaagtgct gggattacag gcatgagcca     2100

ccgcaacaag ccaggaaaga cttctaaggg caggtgacat caaagagcag gtgacattaa     2160

agccaaagct agaatgataa gaagcatgca gtgatctata gtgatcgggg ggaagaggca     2220

tctggtagag ggaacagcaa gtgcaaaggc cctgaggtag gaccaagcct catcttttga     2280

cagtagggag gaggccagtg ctgttggaac agagtgaact ggggagaggg tgggaaagga     2340

aggcacagtt gggcaggggc agattgtgtg gagtttttcg ggctgctgga aagacttttt     2400

cttttctttt tttttttttt tttttttttt tttgagacag agtctcactt tgttgcccag     2460

gctggagtgc aatggcgcca tctcggctca ctgcaacctc tgcctcccgg gttcaagtga     2520

ctctcatgct ttagcctccc aagtagctag aattacaggc acacaccacc atgcctggct     2580

agtttttgta tttttagtag agacggagtt tcgccatgtt ggccaggctg gtctcaaact     2640

cctggcctca agtgatccgc ccaccttggc ctcccaaagt gctgggatta caggcgtgaa     2700

ccactgcacc cagcctggaa agactttaac tttactctga gtgtgatggg agtgattggc     2760

tggttttaaa tacggaagcg acaagacctg atttataact ttaagagatt attctagcaa     2820

gtatagatgc cccttgactt gcaatggtgt tacatcctag taatcccatc ataaattgaa     2880

aataacataa gttgaaaatg cattcaatgc cccgataaac ccatagtaag gtcaaaattg     2940

taagtcaaac cgtcataagt tggggactgt ctgtatagca aaatgttaat tgtagaatct     3000

aattataggt ggcggctata tggcttttaa ctgtgaaatt cttttaactt ttcattatga     3060

agattctcat aagaaaatgt ggtgggggtg gtggtgaaat gctcctggct gttgttggcc     3120

aaaagagatc atgaggcaca agggcagaag cgaggatcct ggagaggtgg cacctgtcat     3180

agtcttgctg aaagatgaca agccctggtg gtagcagcag aggtgcgggg ggggcatttt     3240

tttttttaag aggtagggtc ttgctctgtt ggccaggctg gagtgcagta gtgatcatag     3300

ctcactgcag cctcaaaccg ctggggtcaa gcagttctct cgcctcagtc tccagagtag     3360

ctgagactac aggagcatgc caccacgccc cactaactgt tgcattagtc tttttctata     3420

gagacggggt ctcgctatgt tgtccaggct ggtctccaac agggagggat atttcttttt     3480

ggaagatttt tttttttttt tttttttttt tttgatacag ggtctcgctc tgttaccaag     3540

gctggaatgc agtggcatga ccttggctca ctgcagtctc cacctcctgg gttcaagcaa     3600

ttctacctca gcctcctgag aagctgggat tacaggctct ccccaccaca ccagcaaatg     3660

ggagggatat ttctttcttt ctttcttttt tttttttcct gagacggagt ctctctcggt     3720

tgcacccagg ctggagtgca gtggcgcgat ctcagctcac tgcaacctcc acctcctggg     3780

tttaagcgat tctcttgcct cagtctcccg agtagcttgg gattacaggc gtccgccacc     3840

acacccagct aatttttgca tttttagtag agatggggtt tcaccatgtt ggccaggctg     3900

gtctcgaact ccttacctca ggtgatccgc ctgcctcggt ctcccaaagt gctgggatta     3960

caggcgtgag ccaccgtgct cagctgagag ggatatttct tgatgtgttt tcaagattga     4020

gctgatgggg cctgaacgtc cgagatgagg ggaatagcag tgcaggtgat ggtggcacca     4080

cctacagagc ggggatgata gaatagaagt ggccagataa aggctgcagg agaagtcttg     4140

ggagttggga gagcaggtcg gggtccatgg tcaggggttg atcttctctg gtccagaaaa     4200

gtcctctctg gctgggcgtg gtggctcacg cctgtaatcc cagcactttg ggaggccgag     4260

gcagggggat catgaggtca ggagatcgag accatcctgg ctaacatggt gaaaccccgt     4320

ctctactaaa aatacaaaaa attagccggg catggtggtg ggcacttgta gtcccagcta     4380

ctcgggaggc tgaggcagaa gaatggcgtg aactgggagg cggagtttgc agtgagctga     4440

gattgcacca ctgcactcca gcctggagcg acagagtgag actccgtctc aaaaaaaaaa     4500

aaaaaaaaaa aagaaaagtc ctctctgggg aagtgacatt tgccctgaga gctgaagggt     4560

aagaatttgc ttcgtcgagg cctgtttagg cggaaacagg agtacatgaa gaagtcccga     4620

ggcaggaaga atttgatggg aatttaaaaa attaaaaaaa aaaaaaaaaa tggggctggg     4680

catggtggct cacacctgta atcccggcac tttgggaggc tgaggcatgc ggatcaccta     4740

aggccaggag tttgagacca gcctgaccaa catggtgaaa ccttgtctgc actaaaaatt     4800

caaaaaaaaa aaaaaaaata gcccggtgtg gtggcggatg cctgtaatac cagctgctta     4860

ggaggctcag gcaggaggat cacttaaatc tgggaggcgg aggttgcaat gagccgagac     4920

tgcactattg tactccagcc tgggcaacaa gatcaaaact ctatctcaaa aaaaaaaaaa     4980

aaaattagcc aggcatgttg gcaggcacct gtaatcccaa ccctttggga ggctggggca     5040

ggagaattgc ttgaacccag aaggcaaagc tttcagtgag ccgagattgc gccactgcac     5100

tccatcctgg gtgtcagagc aagactccat cttaaaaaaa aaaaatggaa gcagctcagc     5160

gaggcacaaa acaggaagtg gaaaggtgga gtgaggtcag gccaaagcct gcacacaggg     5220

cttgtgggct gcactgtgcc ttcgggtctt catcctgagg gtactgggga gccacagaag     5280

gctcaggggt ggggcagttg agagtaacat tatcttgttt acaattttat tttttttatt     5340

tatttatttt ttgagacgga ttcttgctct attgtccagg ctggcgtgaa atggcgtgat     5400

ctgggctcac tgcaacctct gcctcctggg ttcaagcgat tcacctgcct cagcatccca     5460

aggagctggg attacaggtg cctgccacca cacccagcta atttttgtat ttatttattt     5520

tgagatggag ttttgctctt gttgcccagg ctggagtgca atggcgcaac ctcggctcac     5580

tgcaacctcc gcctcccggg ttcaagcaat tctcctgcct cagactccca agtagctggg     5640

attacaggca tgtgccacca cgcccggcta attttgtatt tttagtagag atggcattac     5700

tccgtattgg tcaggctggt cttgaactcc cgacctcaag tgatccgcct gccttggcct     5760

cccaaagtgc tgggattaca ggcatgagcc gccgcacctg gccatgttta caatttttga     5820

agccgacttc aattgtgggt ggcagaaatc tttgagggga ggcaaagaat tgacaaagga     5880

ggtttggggc cactatctcc aggcagtggg gacaaggttc agtccctaac gcccactcca     5940

ctccccacag gccctgtgca ccaaggtgcc ggaactgatc agaaccatca tgggctggac     6000

attggacttc ctccgggagc ggctgttggg ctggatccaa gaccagggtg gttgggtgag     6060

actcctcaag cctcctcacc cccaccaccg cgccctcacc accgcccctg ccccaccgtc     6120

cctgcccccc gccactcctc tgggaccctg ggccttctgg agcaggtcac agtggtgccc     6180

tctccccatc ttcagatcat cagatgtggt ctataatgcg ttttccttac gtgtctgatc     6240

aatccccgat tcatctaccc tgctgacctc ccagtgaccc ctgacctcac tgtgaccttg     6300

acttgattag tgccttctgc cctccctgga gcctccactg cctctggaat tgctcaagtt     6360

cattgatgac cctctgaccc tagctctttc cttttttttt ttttccccac tgagaagggg     6420

tctcgctatg ttgcccaggt tggtctcgaa ctcctggcct caagcgatcc tcccgcctca     6480

gcctctcaaa gtgctgggat tacaggtgtg agccaccatg cctggcctga gtccagctct     6540

ttaatgcccg ttcatctcag tcccctgccc gcaatcctgc cttctggcct cctccgtccc     6600

tgatcccgcc tctgcctgcc caggggctgc ccctggccga gtcactgaag cgactgatgt     6660

ccctgtctcc aggacggcct cctctcctac tttgggacgc ccacgtggca gaccgtgacc     6720

atctttgtgg cgggagtgct caccgcctca ctcaccatct ggaagaagat gggctgaggc     6780

ccccagctgc cttggactgt gtttttcctc cataaattat ggcatttttc tgggaggggt     6840

ggggattggg ggacgtgggc atttttctta cttttgtaat tattgggggg tgtggggaag     6900

agtggtcttg agggggtaat aaacctcctt cgggacaca                            6939


<210>  9
<211>  3000
<212>  DNA
<213>  Homo sapiens

<400>  9
gtctgcatcc ggtggccaca gagcaacttc ctctagaggg agctgattgg agccgggtgc       60

cgctggcacc tctatgatca ctggagtctc gcgggtccct cgggctgcac agggacaagt      120

aaaggctaca tccagatgcc gggaatgcac tgacgcccat tcctggaaac tgggctccca      180

ctcagcccct gggagcagca gccgccagcc cctcgggacc tccatctcca ccctgctgag      240

ccacccgggt tgggccagga tcccggcagg taagctggaa gggtcttgtc catcctccca      300

gatctcagca gccccagccc cagggtgggg cagggagcct gccgggagcc gggtggggaa      360

ggggaagctc aaggcttccc tgggcaggtc tgccgccccg gctggggacc tgatcctgcc      420

atgcctgcct ctggctgccc ctcacagctt cccctcttgg cccagccctg gatgccggag      480

aactgtaaga actgggtcct ttaacagtct gggagatggg agtggaggtc agagccaagg      540

tcaagggcag agagagaact ttctcagcgc ttgctgctgc ccaacatccc tagactgggt      600

ccagggcctg gccaggcatg tatccctggg caacattcat cggggcccag caagcccagg      660

aagtcggggg tggctcccct caccgggaat ttaggccact tggatggggg aggcagagct      720

aggcctgagt cagcataggt tgctggcctt ggtgggtgtt ctgaggctct acctgctccc      780

ctcggaagcc tggggtgttg gtagagggag ttggaggtgc agtcagcatc ctccagccct      840

actgtcctgg gggtgccggg tcctggagac tggggaagaa ggaaggccat cttatgtaag      900

gagctacggg gggtgggagg caagcaaaac tctttttttt tgttttttga aatggagtct      960

cgctctgttg cccaggctgg agtgcagtgg cgcaatctcg gctgaccgca acctccgcct     1020

ccaaggttca agcgattctc ctgcctcagc ctcccgagta gctgggacta caggcgcacg     1080

ccaccatgcc cagctaattt ttgtattttt agtagagatg gggtttcatt atgttggcca     1140

agctggtctt gaacttctga cctcgtgggc cactatgccc ggctgcaaag ttctgtttta     1200

acaaggcctt gcccctagag gtggaggaga ggaaggtctg ccttcaccct gtccctgtcc     1260

ggcagatcga ggaggagtgg ggagctgggt gagggcacag gtggtccagc cctcctccac     1320

cccttcttga gagctcttgg ggcactttcg aaaacactcc caggcctagc ggaaggaggg     1380

tgggcgaagg tccccaggcc ctgggcggtg ggggtggggc tgtgtgcttg gcccagggtg     1440

gggctgcaca ccccctccct ctgggatagg aggagggcgc tctccttctg agggctggag     1500

gctgcctggg gaaatggggc tctgggaggg gtgcaaactg aaagtgaaac agctgacatc     1560

caggaaacac tcgccctgat gaggggtcac agcaggttgg ggctgcggtc aggaccaggc     1620

aaagaggaaa attggggccg gggacagaag accaggtgtg tggtgggagt acgaggcagg     1680

ttatggggct tcaaagaagg ccctgatcct gagggctccc tccggtcact gcaaggcagc     1740

agtggggaag gcacagacag gaggtaaata gggaaagttg ccctgagaaa gaacacactc     1800

tgaggtccac aaactggaaa agaaatcttg catgcgtgtt gagtacatgg actcacggag     1860

attcagacaa acaacctgac tttccgtgac taacgatgtg acctcgggca ctcaactctt     1920

tgtgcctcac ttttcctgcc tgtaaagtgg gtatgatggc gctcaccctg ctgggttcat     1980

gtgagtttcc agtgttcacc acccacagag tgctcctaag tgggagagta tatcttaggc     2040

tctcaggaaa tgtttgcggc taacagccca gagttaaaaa acaggtgtgt tctggccagc     2100

cagagggaag tagggcctct gaggacagcc ttcatgggcc attggctggg cagtggctcg     2160

cttgcaataa gcatgtgctg ggtgggctgc aggaggcccc aggaacagct aaaaaccccc     2220

caggctcttg ccccaggagt ggcatgaact tgagagccag cgggcactgc tgcagccaca     2280

ccctcctcga tggtgcagat acctcagtct gcccttggct gcctcacctt cttaccctgt     2340

ctccctcaaa gagggagtgt tcagtaagtt gtttcctccc agcagacttc actgggaccc     2400

atgctggagt aagaataaaa agtcccagag gaggccaggc acggtggctc acacctgtaa     2460

tcccagcact gtggatggcc gaggcagact cacgaggtca ggagtttgag accggcctgg     2520

ccaaagtccc agaggactaa gggcctttct gggaatgggg gatcctctct cctatgtgga     2580

catggcaacc tgtatggggt ccccagtcac aggtctgtgc tcacccccat ctctgctttt     2640

tctcgccctt ccccgcaggc tgatcccgtc ctccactgag acctgaaaaa tggcttcggg     2700

gcaaggccca ggtcctccca ggcaggagtg cggagagcct gccctgccct ctgcttctgg     2760

taagggtctt cctgccccct cacccatccc ataaccatga gtgctgtcgt gaggatggaa     2820

ggagcaggac tcaggcaggc tccttcgcct cggttcaccc actgtgggtg gggaatactc     2880

ttccccaccc acgggctcag aggctggagc tgctgtcaag gttaagccca ggagggggag     2940

gagtctggac tggggagggc ctggaggttg ggagaggcca ggaagtgagt gtaaggtagg     3000


