                         SEQUENCE LISTING

<110>  Rosetta Inpharmatics LLC
       Cleary, M.A.
       Linsley, P.S.
       Lim, L.P.
 
<120>  COMPOSITIONS COMPRISING MIR34 THERAPEUTIC AGENTS FOR TREATING CANCER

<130>  ROSA130262

<150>  US 60/927,621
<151>  2007-05-03

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  1
uggcaguguc uuagcugguu gu                                                22


<210>  2
<211>  110
<212>  RNA
<213>  Homo sapiens

<400>  2
ggccagcugu gaguguuucu uuggcagugu cuuagcuggu uguugugagc aauaguaagg       60

aagcaaucag caaguauacu gcccuagaag ugcugcacgu uguggggccc                 110


<210>  3
<211>  12
<212>  RNA
<213>  Homo sapiens

<400>  3
uggcaguguc uu                                                           12


<210>  4
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  4
aggcaguguc auuagcugau ug                                                22


<210>  5
<211>  84
<212>  RNA
<213>  Homo sapiens

<400>  5
gugcucgguu uguaggcagu gucauuagcu gauuguacug uggugguuac aaucacuaac       60

uccacugcca ucaaaacaag gcac                                              84


<210>  6
<211>  12
<212>  RNA
<213>  Homo sapiens

<400>  6
aggcaguguc au                                                           12


<210>  7
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  7
aggcagugua guuagcugau ug                                                22


<210>  8
<211>  77
<212>  RNA
<213>  Homo sapiens

<400>  8
agucuaguua cuaggcagug uaguuagcug auugcuaaua guaccaauca cuaaccacac       60

ggccagguaa aaagauu                                                      77


<210>  9
<211>  12
<212>  RNA
<213>  Homo sapiens

<400>  9
aggcagugua gu                                                           12


<210>  10
<211>  19
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  TP53 shRNA core sequence

<400>  10
gacuccagug guaaucuac                                                    19


<210>  11
<211>  52
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Full shRNA hairpin sequence targeting TP53 cloned into lentiviral
       vector

<400>  11
gacuccagug guaaucuacu ucaagagagu agauuaccac uggagucuuu uu               52


<210>  12
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  12
aaccagcuaa gacacugcga au                                                22


<210>  13
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34a seed region double mutant guide strand


<220>
<221>  mutation
<222>  (2)..(3)

<400>  13
ucccaguguc uuagcugguu gu                                                22


<210>  14
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34a seed region double mutant, passenger strand


<220>
<221>  mutation
<222>  (18)..(19)

<400>  14
aaccagcuaa gacacuggca au                                                22


<210>  15
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34a non-seed region double mutant, guide strand


<220>
<221>  mutation
<222>  (18)..(19)

<400>  15
uggcaguguc uuagcugcau gu                                                22


<210>  16
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34a non-seed region double mutant, passenger strand


<220>
<221>  mutation
<222>  (2)..(3)

<400>  16
augcagcuaa gacacugcga au                                                22


<210>  17
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  17
aucagcuaau gacacugcgu au                                                22


<210>  18
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34b seed region double mutant, guide strand


<220>
<221>  mutation
<222>  (2)..(3)

<400>  18
acccaguguc auuagcugau ug                                                22


<210>  19
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34b seed region double mutant, passenger strand


<220>
<221>  mutation
<222>  (18)..(19)

<400>  19
aucagcuaau gacacuggcu au                                                22


<210>  20
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34b non-seed region double mutant, guide strand


<220>
<221>  mutation
<222>  (18)..(19)

<400>  20
aggcaguguc auuagcucuu ug                                                22


<210>  21
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34b non-seed region double mutant, passenger strand


<220>
<221>  mutation
<222>  (2)..(3)

<400>  21
aagagcuaau gacacugcgu au                                                22


<210>  22
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  22
aucagcuaac uacacugcgu au                                                22


<210>  23
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34c seed region double mutant, guide strand


<220>
<221>  mutation
<222>  (2)..(3)

<400>  23
acccagugua guuagcugau ug                                                22


<210>  24
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34c seed region double mutant, passenger strand


<220>
<221>  mutation
<222>  (18)..(19)

<400>  24
aucagcuaac uacacuggcu au                                                22


<210>  25
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34c non-seed region double mutant, guide strand


<220>
<221>  mutation
<222>  (18)..(19)

<400>  25
aggcagugua guuagcucuu ug                                                22


<210>  26
<211>  22
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  Synthetic miR-34c non-seed region double mutant, passenger strand


<220>
<221>  mutation
<222>  (2)..(3)

<400>  26
aagagcuaac uacacugcgu au                                                22


<210>  27
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Guide strand of luciferase siRNA


<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  Sequence is RNA/DNA hybrid, wherein N=T

<400>  27
cguacgcgga auacuucgan n                                                 21


<210>  28
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Passenger stand of luciferase siRNA


<220>
<221>  misc_feature
<222>  (18)..(19)
<223>  Sequence is RNA/DNA hybrid, wherein N=T

<400>  28
ucgaaguauu ccguacgnn                                                    19


<210>  29
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  29
uggcagugua uuguuagcug gu                                                22


<210>  30
<211>  91
<212>  RNA
<213>  Homo Sapiens

<400>  30
cuguguguga ugagcuggca guguauuguu agcugguuga auaugugaau ggcaucggcu       60

aacaugcaac ugcugucuua uugcauauac a                                      91


<210>  31
<211>  12
<212>  RNA
<213>  Homo Sapiens

<400>  31
uggcagugua uu                                                           12


<210>  32
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  32
cagcuaacaa uacacuguua au                                                22


<210>  33
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  33
ucccagugua uuguuagcug gu                                                22


<210>  34
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  34
cagcuaacaa uacacuggca au                                                22


<210>  35
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  35
caaucagcaa guauacugcc cu                                                22


<210>  36
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  36
caaucacuaa cuccacugcc au                                                22


<210>  37
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  37
aaucacuaac cacacggcca gg                                                22


<210>  38
<211>  22
<212>  RNA
<213>  Homo Sapiens

<400>  38
aucggcuaac augcaacugc ug                                                22


