                         SEQUENCE LISTING

<110>  Intrexon Corporation
       Reed, Thomas D
       Tretiakova, Anna
       Atzel, Amy
       Bachinsky, David
 
<120>  PP1 LIGANDS

<130>  INX

<150>  60/915611
<151>  2007-05-02

<150>  60/915618
<151>  2007-05-02

<150>  60/915622
<151>  2007-05-02

<150>  60/988021
<151>  2007-11-14

<160>  268   

<170>  PatentIn version 3.5

<210>  1
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  1

Glu Asp Asp Glu Leu Lys Gly Leu Leu Gly Leu Pro Glu Glu Glu Ala 
1               5                   10                  15      


Glu Leu Asp Asn Leu Thr Glu Phe Asn Thr Ala His Asn Lys Arg Ile 
            20                  25                  30          


Ala Thr Leu Thr Ile Glu Glu Gly Asn Leu Asp Ile Gln Arg Pro Lys 
        35                  40                  45              


Arg Lys Arg Lys Asn Ala Arg Val Thr Phe Ala Glu Asp Asp Glu Ile 
    50                  55                  60                  


Ile Asn Pro Glu Asp Val Asp Pro Ser Val Gly Arg Phe Arg Pro Gly 
65                  70                  75                  80  


Ala Gly Gly Arg Arg Thr Glu Leu Cys Gly Thr Leu Asp Tyr Leu Pro 
                85                  90                  95      


Pro Glu Pro Gly Ala Ala Gly Ala Ala Gln Arg Leu Gly Lys Arg Val 
            100                 105                 110         


Leu Ser Lys Leu Gln Ser Pro Ser Arg Ala Arg Gly Pro Gly Gly Ser 
        115                 120                 125             


Pro Gly Gly Leu Gln Lys Arg His Ala Arg Val Glu Val Lys Tyr Asp 
    130                 135                 140                 


Arg Arg Glu Leu Gln Arg Arg Leu Asp Val Glu Lys Trp Ile Asp Gly 
145                 150                 155                 160 


Arg Leu Glu Glu Leu Tyr Arg Gly Met Glu Ala Asp Met Pro Asp Glu 
                165                 170                 175     


Ile Asn Ile Asp Glu Leu Leu Glu Leu Glu Ser Glu Glu Glu Arg Ser 
            180                 185                 190         


Arg Lys Ile Gln Gly Leu Leu Lys Ser Cys Gly Lys Pro Val Glu Asp 
        195                 200                 205             


Phe Ile Gln Glu Leu Leu Ala Lys Leu Gln Gly Leu His Arg Gln Pro 
    210                 215                 220                 


Gly Leu Arg Gln Pro Ser Pro Ser His Asp Gly Ser Leu Ser Pro Leu 
225                 230                 235                 240 


Gln Asp Arg Ala Arg Thr Ala His Pro 
                245                 


<210>  2
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  2
gaggacgacg agctgaaggg cctgctggga ctgcccgagg aggaggccga gctggacaac       60

ctgaccgagt tcaacaccgc ccacaacaag aggatcgcca ccctgaccat cgaggagggc      120

aacctggaca tccagaggcc caagaggaaa aggaagaacg ccagggtgac cttcgccgag      180

gacgacgaga tcatcaaccc cgaggacgtg gaccccagcg tgggcagatt caggcccggc      240

gccggaggca ggaggaccga gctgtgcggc accctggact acctcccccc cgagcccggc      300

gccgccggag ccgcccagag gctgggcaag agggtgctga gcaagctgca gagccccagc      360

agggccaggg gccccggcgg aagccccggc ggactgcaga aaaggcacgc cagggtggag      420

gtgaagtacg acaggaggga gctgcagagg aggctggacg tggagaagtg gatcgacggc      480

aggctggagg agctgtacag gggcatggag gccgacatgc ccgacgagat caacatcgac      540

gagctgctgg agctggagag cgaggaggag aggagcagga agatccaggg cctgctgaaa      600

agctgcggca agcccgtgga ggacttcatc caggagctgc tggccaagct gcagggcctc      660

cacaggcagc ccggcctgag gcagcccagc cccagccacg acggaagcct gagccccctg      720

caagacaggg ccaggaccgc ccacccc                                          747


<210>  3
<211>  781
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  3
gctagcgccg gcgaggacga cgagctgaag ggcctgctgg gactgcccga ggaggaggcc       60

gagctggaca acctgaccga gttcaacacc gcccacaaca agaggatcgc caccctgacc      120

atcgaggagg gcaacctgga catccagagg cccaagagga aaaggaagaa cgccagggtg      180

accttcgccg aggacgacga gatcatcaac cccgaggacg tggaccccag cgtgggcaga      240

ttcaggcccg gcgccggagg caggaggacc gagctgtgcg gcaccctgga ctacctcccc      300

cccgagcccg gcgccgccgg agccgcccag aggctgggca agagggtgct gagcaagctg      360

cagagcccca gcagggccag gggccccggc ggaagccccg gcggactgca gaaaaggcac      420

gccagggtgg aggtgaagta cgacaggagg gagctgcaga ggaggctgga cgtggagaag      480

tggatcgacg gcaggctgga ggagctgtac aggggcatgg aggccgacat gcccgacgag      540

atcaacatcg acgagctgct ggagctggag agcgaggagg agaggagcag gaagatccag      600

ggcctgctga aaagctgcgg caagcccgtg gaggacttca tccaggagct gctggccaag      660

ctgcagggcc tccacaggca gcccggcctg aggcagccca gccccagcca cgacggaagc      720

ctgagccccc tgcaagacag ggccaggacc gcccaccccc ccgggggagg cggaatcgat      780

t                                                                      781


<210>  4
<211>  790
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  4
gctagcgcca ccatggccgg cgaggacgac gagctgaagg gcctgctggg actgcccgag       60

gaggaggccg agctggacaa cctgaccgag ttcaacaccg cccacaacaa gaggatcgcc      120

accctgacca tcgaggaggg caacctggac atccagaggc ccaagaggaa aaggaagaac      180

gccagggtga ccttcgccga ggacgacgag atcatcaacc ccgaggacgt ggaccccagc      240

gtgggcagat tcaggcccgg cgccggaggc aggaggaccg agctgtgcgg caccctggac      300

tacctccccc ccgagcccgg cgccgccgga gccgcccaga ggctgggcaa gagggtgctg      360

agcaagctgc agagccccag cagggccagg ggccccggcg gaagccccgg cggactgcag      420

aaaaggcacg ccagggtgga ggtgaagtac gacaggaggg agctgcagag gaggctggac      480

gtggagaagt ggatcgacgg caggctggag gagctgtaca ggggcatgga ggccgacatg      540

cccgacgaga tcaacatcga cgagctgctg gagctggaga gcgaggagga gaggagcagg      600

aagatccagg gcctgctgaa aagctgcggc aagcccgtgg aggacttcat ccaggagctg      660

ctggccaagc tgcagggcct ccacaggcag cccggcctga ggcagcccag ccccagccac      720

gacggaagcc tgagccccct gcaagacagg gccaggaccg cccacccccc cgggggaggc      780

ggaatcgatt                                                             790


<210>  5
<211>  247
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  5

Arg Lys Leu Asn Gln Arg Pro Thr Val Asp Glu Leu Arg Asp Arg Lys 
1               5                   10                  15      


Ile Leu Ile Arg Phe Ser Asp Tyr Val Glu Val Ala Lys Ala Gln Asp 
            20                  25                  30          


Tyr Asp Arg Arg Ala Asp Lys Pro Trp Thr Arg Leu Ser Ala Ala Asp 
        35                  40                  45              


Lys Ala Ala Ile Arg Lys Glu Leu Asn Glu Tyr Lys Ser Asn Glu Met 
    50                  55                  60                  


Glu Val His Ala Ser Ser Lys His Leu Thr Arg Phe His Arg Pro Pro 
65                  70                  75                  80  


Gly Ala Gly Gly Glu Glu Pro Gln Ser Asp Pro Ser Val Glu Pro Pro 
                85                  90                  95      


Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu Leu Pro Glu Asn 
            100                 105                 110         


Asn Val Leu Ser Pro Leu Pro Ser Gln Ala Met Asp Asp Leu Met Leu 
        115                 120                 125             


Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr Glu Asp Pro Gly Pro Pro 
    130                 135                 140                 


Gly Ala Ala Gly Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr 
145                 150                 155                 160 


Val Pro Leu Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile 
                165                 170                 175     


Arg Arg Arg Arg Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln 
            180                 185                 190         


Ser Ser Pro Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys 
        195                 200                 205             


Ser Thr Leu Ala Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Ile 
    210                 215                 220                 


Thr Pro Thr Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly 
225                 230                 235                 240 


Gln Gln Gln Gln Gly Glu Glu 
                245         


<210>  6
<211>  741
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  6
aggaagctga accagaggcc caccgtggac gagctgaggg acaggaagat cctgatcagg       60

ttcagcgact acgtggaggt ggccaaggcc caggactacg acaggagggc cgacaagccc      120

tggaccaggc tgagcgccgc cgacaaagcc gccatcagga aggagctgaa cgagtacaag      180

agcaacgaga tggaggtcca cgccagcagc aagcacctga ccaggttcca caggcccccc      240

ggcgccggag gcgaggagcc ccagagcgac cccagcgtgg agccccccct gagccaggag      300

accttcagcg acctgtggaa gctgctgccc gagaacaacg tgctgagccc cctgcccagc      360

caggccatgg acgacctgat gctgagcccc gacgacatcg agcagtggtt caccgaggac      420

cccggccccc ccggagccgc cggagagcag gacaacagcc cccagaagat ccagttcacc      480

gtgcccctgc tggagcccca cctggacccc gaggccgccg agcagatcag gaggaggagg      540

cccacccccg ccaccctggt gctgaccagc gaccagagca gccccgagat cgacgaggac      600

aggattccca acccccacct gaaaagcacc ctggccatga gccccaggca gaggaagaag      660

atgaccagga tcacccccac catgaaggag ctgcagatga tggtggagca ccacctgggc      720

cagcagcagc agggcgagga g                                                741


<210>  7
<211>  775
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  7
gctagcgccg gcaggaagct gaaccagagg cccaccgtgg acgagctgag ggacaggaag       60

atcctgatca ggttcagcga ctacgtggag gtggccaagg cccaggacta cgacaggagg      120

gccgacaagc cctggaccag gctgagcgcc gccgacaaag ccgccatcag gaaggagctg      180

aacgagtaca agagcaacga gatggaggtc cacgccagca gcaagcacct gaccaggttc      240

cacaggcccc ccggcgccgg aggcgaggag ccccagagcg accccagcgt ggagcccccc      300

ctgagccagg agaccttcag cgacctgtgg aagctgctgc ccgagaacaa cgtgctgagc      360

cccctgccca gccaggccat ggacgacctg atgctgagcc ccgacgacat cgagcagtgg      420

ttcaccgagg accccggccc ccccggagcc gccggagagc aggacaacag cccccagaag      480

atccagttca ccgtgcccct gctggagccc cacctggacc ccgaggccgc cgagcagatc      540

aggaggagga ggcccacccc cgccaccctg gtgctgacca gcgaccagag cagccccgag      600

atcgacgagg acaggattcc caacccccac ctgaaaagca ccctggccat gagccccagg      660

cagaggaaga agatgaccag gatcaccccc accatgaagg agctgcagat gatggtggag      720

caccacctgg gccagcagca gcagggcgag gagcccgggg gaggcggaat cgatt           775


<210>  8
<211>  784
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  8
gctagcgcca ccatggccgg caggaagctg aaccagaggc ccaccgtgga cgagctgagg       60

gacaggaaga tcctgatcag gttcagcgac tacgtggagg tggccaaggc ccaggactac      120

gacaggaggg ccgacaagcc ctggaccagg ctgagcgccg ccgacaaagc cgccatcagg      180

aaggagctga acgagtacaa gagcaacgag atggaggtcc acgccagcag caagcacctg      240

accaggttcc acaggccccc cggcgccgga ggcgaggagc cccagagcga ccccagcgtg      300

gagccccccc tgagccagga gaccttcagc gacctgtgga agctgctgcc cgagaacaac      360

gtgctgagcc ccctgcccag ccaggccatg gacgacctga tgctgagccc cgacgacatc      420

gagcagtggt tcaccgagga ccccggcccc cccggagccg ccggagagca ggacaacagc      480

ccccagaaga tccagttcac cgtgcccctg ctggagcccc acctggaccc cgaggccgcc      540

gagcagatca ggaggaggag gcccaccccc gccaccctgg tgctgaccag cgaccagagc      600

agccccgaga tcgacgagga caggattccc aacccccacc tgaaaagcac cctggccatg      660

agccccaggc agaggaagaa gatgaccagg atcaccccca ccatgaagga gctgcagatg      720

atggtggagc accacctggg ccagcagcag cagggcgagg agcccggggg aggcggaatc      780

gatt                                                                   784


<210>  9
<211>  229
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  9

Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser Ala Ser Pro 
1               5                   10                  15      


His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys Pro Pro Asp 
            20                  25                  30          


Ala Pro Gly Pro Asp Glu Ala Pro Lys Gly Ala His His Lys Lys Tyr 
        35                  40                  45              


Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln Met Gly Thr 
    50                  55                  60                  


Thr Ala Gly Pro Ser Gly Glu Ala Gly Gly Gly Ala Gly Leu Ala Glu 
65                  70                  75                  80  


Ala Pro Arg Ala Ser Glu Arg Gly Val Arg Leu Ser Leu Pro Arg Ala 
                85                  90                  95      


Ser Ser Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu Lys Leu Gly 
            100                 105                 110         


Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys Pro Gly Gly 
        115                 120                 125             


Ala Gly Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys 
    130                 135                 140                 


Arg Trp Ile Gly Asp Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg 
145                 150                 155                 160 


Gln Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala 
                165                 170                 175     


Cys Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu Pro Gly Ala 
            180                 185                 190         


Ala Gly Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala 
        195                 200                 205             


Pro Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg 
    210                 215                 220                 


Arg Pro Thr Pro Ala 
225                 


<210>  10
<211>  687
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  10
aagaccgagc ccaggggccc cggcggaccc ctgaggagcg ccagccccca caggagcgcc       60

tacgaagccg gaatccaggc cctgaagccc cccgacgccc ccggccccga cgaggccccc      120

aagggcgccc accacaagaa gtacggcagc aacgtgcata ggatcaagag catgttcctg      180

cagatgggca ccaccgccgg acccagcggc gaggccggag gcggcgccgg actcgccgag      240

gcccccagag ccagcgagag gggcgtgagg ctgagcctgc ccagggccag cagcctgaac      300

gagaacgtgg accacagcgc cctgctgaag ctgggcacca gcgtgagcga gagggtgtcc      360

aggttcgaca gcaagcccgg cggcgccgga aagatggccg acgccaagca gaaaaggaac      420

gagcagctga aaaggtggat cggcgacgag accgacctgg agccccccgt ggtgaaaagg      480

cagaagacca aggtgaagtt cgacgacggc gccgtgttcc tggccgcctg cagcagcggc      540

gacaccgacg aggtgctgaa gctgctgccc ggcgccgccg gagaccccaa ggacaggaag      600

aagatccagt tcagcgtgcc cgcccccccc agccagctcg accccaggca agtcgagatg      660

atcaggagga ggaggcccac ccccgcc                                          687


<210>  11
<211>  721
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  11
gctagcgccg gcaagaccga gcccaggggc cccggcggac ccctgaggag cgccagcccc       60

cacaggagcg cctacgaagc cggaatccag gccctgaagc cccccgacgc ccccggcccc      120

gacgaggccc ccaagggcgc ccaccacaag aagtacggca gcaacgtgca taggatcaag      180

agcatgttcc tgcagatggg caccaccgcc ggacccagcg gcgaggccgg aggcggcgcc      240

ggactcgccg aggcccccag agccagcgag aggggcgtga ggctgagcct gcccagggcc      300

agcagcctga acgagaacgt ggaccacagc gccctgctga agctgggcac cagcgtgagc      360

gagagggtgt ccaggttcga cagcaagccc ggcggcgccg gaaagatggc cgacgccaag      420

cagaaaagga acgagcagct gaaaaggtgg atcggcgacg agaccgacct ggagcccccc      480

gtggtgaaaa ggcagaagac caaggtgaag ttcgacgacg gcgccgtgtt cctggccgcc      540

tgcagcagcg gcgacaccga cgaggtgctg aagctgctgc ccggcgccgc cggagacccc      600

aaggacagga agaagatcca gttcagcgtg cccgcccccc ccagccagct cgaccccagg      660

caagtcgaga tgatcaggag gaggaggccc acccccgccc ccgggggagg cggaatcgat      720

t                                                                      721


<210>  12
<211>  730
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  12
gctagcgcca ccatggccgg caagaccgag cccaggggcc ccggcggacc cctgaggagc       60

gccagccccc acaggagcgc ctacgaagcc ggaatccagg ccctgaagcc ccccgacgcc      120

cccggccccg acgaggcccc caagggcgcc caccacaaga agtacggcag caacgtgcat      180

aggatcaaga gcatgttcct gcagatgggc accaccgccg gacccagcgg cgaggccgga      240

ggcggcgccg gactcgccga ggcccccaga gccagcgaga ggggcgtgag gctgagcctg      300

cccagggcca gcagcctgaa cgagaacgtg gaccacagcg ccctgctgaa gctgggcacc      360

agcgtgagcg agagggtgtc caggttcgac agcaagcccg gcggcgccgg aaagatggcc      420

gacgccaagc agaaaaggaa cgagcagctg aaaaggtgga tcggcgacga gaccgacctg      480

gagccccccg tggtgaaaag gcagaagacc aaggtgaagt tcgacgacgg cgccgtgttc      540

ctggccgcct gcagcagcgg cgacaccgac gaggtgctga agctgctgcc cggcgccgcc      600

ggagacccca aggacaggaa gaagatccag ttcagcgtgc ccgccccccc cagccagctc      660

gaccccaggc aagtcgagat gatcaggagg aggaggccca cccccgcccc cgggggaggc      720

ggaatcgatt                                                             730


<210>  13
<211>  238
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  13

Gly Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val 
1               5                   10                  15      


Thr Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu 
            20                  25                  30          


Asp Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu 
        35                  40                  45              


Ala Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala 
    50                  55                  60                  


Arg Arg Pro Gly Gly Ala Gly Tyr Asp Pro Thr Ser Pro Asn Tyr Asp 
65                  70                  75                  80  


Pro Thr Ser Pro Asn Tyr Thr Pro Thr Ser Pro Ser Tyr Asp Pro Thr 
                85                  90                  95      


Ser Pro Ser Tyr Asp Pro Thr Ser Pro Asn Tyr Thr Pro Thr Ser Pro 
            100                 105                 110         


Asn Tyr Asp Pro Thr Ser Pro Ser Tyr Asp Pro Thr Ser Pro Ser Pro 
        115                 120                 125             


Gly Ala Ala Gly Ser Cys Thr Arg Met Ile Gln Val Leu Asp Pro Arg 
    130                 135                 140                 


Pro Leu Thr Ser Ser Val Met Pro Val Asp Val Ala Met Arg Leu Cys 
145                 150                 155                 160 


Leu Ala His Ser Pro Pro Val Lys Ser Phe Leu Gly Pro Tyr Asp Glu 
                165                 170                 175     


Phe Gln Arg Arg His Phe Val Asn Lys Leu Lys Pro Leu Lys Ser Cys 
            180                 185                 190         


Leu Asn Ile Lys His Lys Ala Lys Ser Gln Asn Asp Trp Lys Cys Ser 
        195                 200                 205             


His Asn Gln Ala Lys Lys Arg Val Val Phe Ala Asp Ser Lys Gly Leu 
    210                 215                 220                 


Ser Leu Thr Ala Ile His Val Phe Ser Asp Leu Pro Glu Glu 
225                 230                 235             


<210>  14
<211>  714
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  14
ggcgacccca accagctgac caggaagggc aggaaaagga aaagcgtgac ctggcccgag       60

gagggcaagc tgagggagta cttctacttc gagctggacg agaccgagag ggtgaacgtg      120

aacaagatca aggacttcgg cgaggccgcc aagagggaga tcctgagcga caggcacgcc      180

ttcgagaccg ccaggaggcc cggcggcgcc ggatacgacc ccaccagccc caactacgac      240

cccaccagcc ccaactacac ccccaccagc cccagctacg accccaccag ccccagctac      300

gaccccacca gccccaacta cacccccacc agccccaact acgaccccac cagccccagc      360

tacgacccca ccagccccag ccccggcgcc gccggaagct gcaccaggat gatccaggtg      420

ctggacccca ggcccctgac cagcagcgtg atgcccgtgg acgtggccat gaggctgtgc      480

ctggcccaca gcccccccgt gaaaagcttc ctgggcccct acgacgagtt ccagaggagg      540

cacttcgtca acaagctgaa gcccctgaaa agctgcctga acatcaagca caaggccaag      600

agccagaacg actggaagtg cagccacaac caggccaaga aaagggtggt gttcgccgac      660

agcaagggcc tgagcctgac cgccatccac gtcttcagcg acctccccga ggag            714


<210>  15
<211>  748
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  15
gctagcgccg gcggcgaccc caaccagctg accaggaagg gcaggaaaag gaaaagcgtg       60

acctggcccg aggagggcaa gctgagggag tacttctact tcgagctgga cgagaccgag      120

agggtgaacg tgaacaagat caaggacttc ggcgaggccg ccaagaggga gatcctgagc      180

gacaggcacg ccttcgagac cgccaggagg cccggcggcg ccggatacga ccccaccagc      240

cccaactacg accccaccag ccccaactac acccccacca gccccagcta cgaccccacc      300

agccccagct acgaccccac cagccccaac tacaccccca ccagccccaa ctacgacccc      360

accagcccca gctacgaccc caccagcccc agccccggcg ccgccggaag ctgcaccagg      420

atgatccagg tgctggaccc caggcccctg accagcagcg tgatgcccgt ggacgtggcc      480

atgaggctgt gcctggccca cagccccccc gtgaaaagct tcctgggccc ctacgacgag      540

ttccagagga ggcacttcgt caacaagctg aagcccctga aaagctgcct gaacatcaag      600

cacaaggcca agagccagaa cgactggaag tgcagccaca accaggccaa gaaaagggtg      660

gtgttcgccg acagcaaggg cctgagcctg accgccatcc acgtcttcag cgacctcccc      720

gaggagcccg ggggaggcgg aatcgatt                                         748


<210>  16
<211>  757
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  16
gctagcgcca ccatggccgg cggcgacccc aaccagctga ccaggaaggg caggaaaagg       60

aaaagcgtga cctggcccga ggagggcaag ctgagggagt acttctactt cgagctggac      120

gagaccgaga gggtgaacgt gaacaagatc aaggacttcg gcgaggccgc caagagggag      180

atcctgagcg acaggcacgc cttcgagacc gccaggaggc ccggcggcgc cggatacgac      240

cccaccagcc ccaactacga ccccaccagc cccaactaca cccccaccag ccccagctac      300

gaccccacca gccccagcta cgaccccacc agccccaact acacccccac cagccccaac      360

tacgacccca ccagccccag ctacgacccc accagcccca gccccggcgc cgccggaagc      420

tgcaccagga tgatccaggt gctggacccc aggcccctga ccagcagcgt gatgcccgtg      480

gacgtggcca tgaggctgtg cctggcccac agcccccccg tgaaaagctt cctgggcccc      540

tacgacgagt tccagaggag gcacttcgtc aacaagctga agcccctgaa aagctgcctg      600

aacatcaagc acaaggccaa gagccagaac gactggaagt gcagccacaa ccaggccaag      660

aaaagggtgg tgttcgccga cagcaagggc ctgagcctga ccgccatcca cgtcttcagc      720

gacctccccg aggagcccgg gggaggcgga atcgatt                               757


<210>  17
<211>  316
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  17

Ala Ala Gln Arg Leu Gly Lys Arg Val Leu Ser Lys Leu Gln Ser Pro 
1               5                   10                  15      


Ser Arg Ala Arg Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys Arg 
            20                  25                  30          


His Ala Arg Val Glu Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg 
        35                  40                  45              


Leu Asp Val Glu Lys Trp Ile Asp Gly Arg Glu Glu Leu Tyr Arg Gly 
    50                  55                  60                  


Met Glu Ala Asp Met Pro Asp Glu Ile Asn Ile Asp Glu Leu Leu Glu 
65                  70                  75                  80  


Leu Glu Ser Glu Glu Glu Arg Ser Arg Lys Ile Gln Gly Leu Leu Lys 
                85                  90                  95      


Ser Cys Gly Lys Pro Val Glu Asp Phe Ile Gln Glu Leu Leu Ala Lys 
            100                 105                 110         


Leu Gln Gly Leu His Arg Gln Pro Gly Leu Arg Gln Pro Ser Pro Ser 
        115                 120                 125             


His Asp Gly Ser Leu Ser Pro Leu Gln Asp Arg Ala Arg Thr Ala His 
    130                 135                 140                 


Pro Pro Gly Ala Gly His Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser 
145                 150                 155                 160 


Ser Pro Leu Arg Ile Pro Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys 
                165                 170                 175     


Ser Pro Tyr Lys Ile Ser Glu Gly Leu Pro Asp Pro Thr Lys Met Asp 
            180                 185                 190         


Pro Arg Ser Arg Ile Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser 
        195                 200                 205             


Glu Lys Phe Gln Lys Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val 
    210                 215                 220                 


Leu Lys Arg Ser Ala Glu Gly Ser Asn Pro Gly Ala Ala Gly Glu Asp 
225                 230                 235                 240 


Asp Glu Leu Lys Gly Leu Leu Gly Leu Pro Glu Glu Glu Ala Glu Leu 
                245                 250                 255     


Asp Asn Leu Thr Glu Phe Asn Thr Ala His Asn Lys Arg Ile Ala Thr 
            260                 265                 270         


Leu Thr Ile Glu Glu Gly Asn Leu Asp Ile Gln Arg Pro Lys Arg Lys 
        275                 280                 285             


Arg Lys Asn Ala Arg Val Thr Phe Ala Glu Asp Asp Glu Ile Ile Asn 
    290                 295                 300                 


Pro Glu Asp Val Asp Pro Ser Val Gly Arg Phe Arg 
305                 310                 315     


<210>  18
<211>  948
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  18
gccgcccaga ggctgggcaa gagggtgctg agcaagctgc agagccccag cagggccagg       60

ggccccggcg gaagccccgg cggactgcag aaaaggcacg ccagggtgga ggtgaagtac      120

gacaggaggg agctgcagag gaggctggac gtggagaagt ggatcgacgg cagggaggag      180

ctgtacaggg gcatggaggc cgacatgccc gacgagatca acatcgacga gctgctggag      240

ctggagagcg aggaggagag gagcaggaag atccagggcc tgctgaaaag ctgcggcaag      300

cccgtggagg acttcatcca ggagctgctg gccaagctgc agggcctcca caggcagccc      360

ggcctgaggc agcccagccc cagccacgac ggaagcctga gccccctgca agacagggcc      420

aggaccgccc acccccccgg cgccggacac atccccagga gcccctacaa gttccccagc      480

agccccctga ggattcccgg cggcaacatc tacatcagcc ccctgaaaag cccctacaag      540

atcagcgagg gcctgcccga ccctaccaag atggacccca ggagcaggat tctggtgagc      600

atcggcgaga gcttcggcac cagcgagaag ttccagaaga tcaaccagat ggtgtgcaac      660

agcgacaggg tgctgaaaag gagcgccgag ggcagcaacc ccggcgccgc cggagaggac      720

gacgagctga agggcctgct gggactgccc gaggaggagg ccgagctgga caacctgacc      780

gagttcaaca ccgcccacaa caagaggatc gccaccctga ccatcgagga gggcaacctg      840

gacatccaga ggcccaagag gaaaaggaag aacgccaggg tgaccttcgc cgaggacgac      900

gagatcatca accccgagga cgtggacccc agcgtgggca gattcagg                   948


<210>  19
<211>  982
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  19
gctagcgccg gcgccgccca gaggctgggc aagagggtgc tgagcaagct gcagagcccc       60

agcagggcca ggggccccgg cggaagcccc ggcggactgc agaaaaggca cgccagggtg      120

gaggtgaagt acgacaggag ggagctgcag aggaggctgg acgtggagaa gtggatcgac      180

ggcagggagg agctgtacag gggcatggag gccgacatgc ccgacgagat caacatcgac      240

gagctgctgg agctggagag cgaggaggag aggagcagga agatccaggg cctgctgaaa      300

agctgcggca agcccgtgga ggacttcatc caggagctgc tggccaagct gcagggcctc      360

cacaggcagc ccggcctgag gcagcccagc cccagccacg acggaagcct gagccccctg      420

caagacaggg ccaggaccgc ccaccccccc ggcgccggac acatccccag gagcccctac      480

aagttcccca gcagccccct gaggattccc ggcggcaaca tctacatcag ccccctgaaa      540

agcccctaca agatcagcga gggcctgccc gaccctacca agatggaccc caggagcagg      600

attctggtga gcatcggcga gagcttcggc accagcgaga agttccagaa gatcaaccag      660

atggtgtgca acagcgacag ggtgctgaaa aggagcgccg agggcagcaa ccccggcgcc      720

gccggagagg acgacgagct gaagggcctg ctgggactgc ccgaggagga ggccgagctg      780

gacaacctga ccgagttcaa caccgcccac aacaagagga tcgccaccct gaccatcgag      840

gagggcaacc tggacatcca gaggcccaag aggaaaagga agaacgccag ggtgaccttc      900

gccgaggacg acgagatcat caaccccgag gacgtggacc ccagcgtggg cagattcagg      960

cccgggggag gcggaatcga tt                                               982


<210>  20
<211>  991
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  20
gctagcgcca ccatggccgg cgccgcccag aggctgggca agagggtgct gagcaagctg       60

cagagcccca gcagggccag gggccccggc ggaagccccg gcggactgca gaaaaggcac      120

gccagggtgg aggtgaagta cgacaggagg gagctgcaga ggaggctgga cgtggagaag      180

tggatcgacg gcagggagga gctgtacagg ggcatggagg ccgacatgcc cgacgagatc      240

aacatcgacg agctgctgga gctggagagc gaggaggaga ggagcaggaa gatccagggc      300

ctgctgaaaa gctgcggcaa gcccgtggag gacttcatcc aggagctgct ggccaagctg      360

cagggcctcc acaggcagcc cggcctgagg cagcccagcc ccagccacga cggaagcctg      420

agccccctgc aagacagggc caggaccgcc cacccccccg gcgccggaca catccccagg      480

agcccctaca agttccccag cagccccctg aggattcccg gcggcaacat ctacatcagc      540

cccctgaaaa gcccctacaa gatcagcgag ggcctgcccg accctaccaa gatggacccc      600

aggagcagga ttctggtgag catcggcgag agcttcggca ccagcgagaa gttccagaag      660

atcaaccaga tggtgtgcaa cagcgacagg gtgctgaaaa ggagcgccga gggcagcaac      720

cccggcgccg ccggagagga cgacgagctg aagggcctgc tgggactgcc cgaggaggag      780

gccgagctgg acaacctgac cgagttcaac accgcccaca acaagaggat cgccaccctg      840

accatcgagg agggcaacct ggacatccag aggcccaaga ggaaaaggaa gaacgccagg      900

gtgaccttcg ccgaggacga cgagatcatc aaccccgagg acgtggaccc cagcgtgggc      960

agattcaggc ccgggggagg cggaatcgat t                                     991


<210>  21
<211>  251
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  21

Pro Ala Val Arg Pro Thr Phe Arg Val Leu Val Gly Glu Val Glu Gln 
1               5                   10                  15      


Ile Val Ser Ala Leu Leu Gly Asp His Tyr Val Gln Leu Pro Ala Thr 
            20                  25                  30          


Tyr Met Asn Leu Gly Pro Ser Thr Ser His Glu Met Asn Val Arg Pro 
        35                  40                  45              


Glu Gln Pro Gln Phe Ser Pro Met Pro Gly Asn Val Arg Arg Pro Arg 
    50                  55                  60                  


Pro Leu Asp Glu Pro Pro Arg Pro Thr Pro Gly Gly Ala Gly Arg Lys 
65                  70                  75                  80  


Leu Asn Gln Arg Pro Thr Val Asp Glu Leu Arg Asp Arg Lys Ile Leu 
                85                  90                  95      


Ile Arg Phe Ser Asp Tyr Val Glu Val Ala Lys Ala Gln Asp Tyr Asp 
            100                 105                 110         


Arg Arg Ala Asp Lys Pro Trp Thr Arg Leu Ser Ala Ala Asp Lys Ala 
        115                 120                 125             


Ala Ile Arg Lys Glu Leu Asn Glu Tyr Lys Ser Asn Glu Met Glu Val 
    130                 135                 140                 


His Ala Ser Ser Lys His Leu Thr Arg Phe His Arg Pro Pro Gly Ala 
145                 150                 155                 160 


Ala Gly Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala 
                165                 170                 175     


Pro Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg 
            180                 185                 190         


Arg Pro Glu Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro 
        195                 200                 205             


Glu Glu Glu Ala Ser Pro His Gln Arg Ala Ser Gly Glu Gly His His 
    210                 215                 220                 


Leu Lys Ser Lys Arg Pro Asn Pro Cys Ala Tyr Thr Pro Pro Ser Leu 
225                 230                 235                 240 


Lys Ala Val Gln Arg Ile Ala Glu Ser His Leu 
                245                 250     


<210>  22
<211>  753
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  22
cccgccgtga ggcccacctt cagggtgctg gtgggcgagg tggagcagat cgtgagcgcc       60

ctgctgggcg accactacgt ccagctgccc gccacctaca tgaacctggg ccccagcacc      120

agccacgaga tgaacgtgag gcccgagcag ccccagttca gccccatgcc cggcaacgtg      180

aggaggccca ggcccctcga cgagcccccc agacccaccc ccggcggcgc cggaaggaag      240

ctgaaccaga ggcccaccgt ggacgagctg agggacagga agatcctgat caggttcagc      300

gactacgtgg aggtggccaa ggcccaggac tacgacagga gggccgacaa gccctggacc      360

aggctgagcg ccgccgacaa agccgccatc aggaaggagc tgaacgagta caagagcaac      420

gagatggagg tccacgccag cagcaagcac ctgaccaggt tccacaggcc ccccggcgcc      480

gccggagacc ccaaggacag gaagaagatc cagttcagcg tgcccgcccc ccccagccag      540

ctcgacccca ggcaagtcga gatgatcagg aggaggaggc ccgagcccgc catgctgttc      600

aggctgagcg agcacagcag ccccgaggag gaggccagcc cccaccagag ggccagcggc      660

gagggccacc acctgaaaag caagaggccc aacccctgcg cctacacccc ccccagcctg      720

aaggccgtgc agaggatcgc cgagagccac ctg                                   753


<210>  23
<211>  787
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  23
gctagcgccg gccccgccgt gaggcccacc ttcagggtgc tggtgggcga ggtggagcag       60

atcgtgagcg ccctgctggg cgaccactac gtccagctgc ccgccaccta catgaacctg      120

ggccccagca ccagccacga gatgaacgtg aggcccgagc agccccagtt cagccccatg      180

cccggcaacg tgaggaggcc caggcccctc gacgagcccc ccagacccac ccccggcggc      240

gccggaagga agctgaacca gaggcccacc gtggacgagc tgagggacag gaagatcctg      300

atcaggttca gcgactacgt ggaggtggcc aaggcccagg actacgacag gagggccgac      360

aagccctgga ccaggctgag cgccgccgac aaagccgcca tcaggaagga gctgaacgag      420

tacaagagca acgagatgga ggtccacgcc agcagcaagc acctgaccag gttccacagg      480

ccccccggcg ccgccggaga ccccaaggac aggaagaaga tccagttcag cgtgcccgcc      540

ccccccagcc agctcgaccc caggcaagtc gagatgatca ggaggaggag gcccgagccc      600

gccatgctgt tcaggctgag cgagcacagc agccccgagg aggaggccag cccccaccag      660

agggccagcg gcgagggcca ccacctgaaa agcaagaggc ccaacccctg cgcctacacc      720

ccccccagcc tgaaggccgt gcagaggatc gccgagagcc acctgcccgg gggaggcgga      780

atcgatt                                                                787


<210>  24
<211>  799
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  24
gctagcgcca ccatggccgg cggacccgcc gtgaggccca ccttcagggt gctggtgggc       60

gaggtggagc agatcgtgag cgccctgctg ggcgaccact acgtccagct gcccgccacc      120

tacatgaacc tgggccccag caccagccac gagatgaacg tgaggcccga gcagccccag      180

ttcagcccca tgcccggcaa cgtgaggagg cccaggcccc tcgacgagcc ccccagaccc      240

acccccggcg gcgccggaag gaagctgaac cagaggccca ccgtggacga gctgagggac      300

aggaagatcc tgatcaggtt cagcgactac gtggaggtgg ccaaggccca ggactacgac      360

aggagggccg acaagccctg gaccaggctg agcgccgccg acaaagccgc catcaggaag      420

gagctgaacg agtacaagag caacgagatg gaggtccacg ccagcagcaa gcacctgacc      480

aggttccaca ggccccccgg cgccgccgga gaccccaagg acaggaagaa gatccagttc      540

agcgtgcccg ccccccccag ccagctcgac cccaggcaag tcgagatgat caggaggagg      600

aggcccgagc ccgccatgct gttcaggctg agcgagcaca gcagccccga ggaggaggcc      660

agcccccacc agagggccag cggcgagggc caccacctga aaagcaagag gcccaacccc      720

tgcgcctaca ccccccccag cctgaaggcc gtgcagagga tcgccgagag ccacctgccc      780

gggggaggcg gaatcgatt                                                   799


<210>  25
<211>  281
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  25

Gly Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val 
1               5                   10                  15      


Thr Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu 
            20                  25                  30          


Asp Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu 
        35                  40                  45              


Ala Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala 
    50                  55                  60                  


Arg Arg Pro Gly Gly Ala Gly Ser Cys Thr Arg Met Ile Gln Val Leu 
65                  70                  75                  80  


Asp Pro Arg Pro Leu Thr Ser Ser Val Met Pro Val Asp Val Ala Met 
                85                  90                  95      


Arg Leu Cys Leu Ala His Ser Pro Pro Val Lys Ser Phe Leu Gly Pro 
            100                 105                 110         


Tyr Asp Glu Phe Gln Arg Arg His Phe Val Asn Lys Leu Lys Pro Leu 
        115                 120                 125             


Lys Ser Cys Leu Asn Ile Lys His Lys Ala Lys Ser Gln Asn Asp Trp 
    130                 135                 140                 


Lys Cys Ser His Asn Gln Ala Lys Lys Arg Val Val Phe Ala Asp Ser 
145                 150                 155                 160 


Lys Gly Leu Ser Leu Thr Ala Ile His Val Phe Ser Asp Leu Pro Glu 
                165                 170                 175     


Glu Pro Gly Ala Ala Gly Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln 
            180                 185                 190         


Phe Thr Val Pro Leu Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu 
        195                 200                 205             


Gln Ile Arg Arg Arg Arg Pro Glu Pro Ala Thr Leu Val Leu Thr Ser 
    210                 215                 220                 


Asp Gln Ser Ser Pro Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His 
225                 230                 235                 240 


Leu Lys Ser Thr Leu Ala Met Asp Pro Arg Gln Arg Lys Lys Met Glu 
                245                 250                 255     


Arg Ile Thr Pro Thr Met Lys Glu Leu Gln Met Met Val Glu His His 
            260                 265                 270         


Leu Gly Gln Gln Gln Gln Gly Glu Glu 
        275                 280     


<210>  26
<211>  843
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  26
ggcgacccca accagctgac caggaagggc aggaaaagga aaagcgtgac ctggcccgag       60

gagggcaagc tgagggagta cttctacttc gagctggacg agaccgagag ggtgaacgtg      120

aacaagatca aggacttcgg cgaggccgcc aagagggaga tcctgagcga caggcacgcc      180

ttcgagaccg ccaggaggcc cggcggcgcc ggaagctgca ccaggatgat ccaggtgctg      240

gaccccaggc ccctgaccag cagcgtgatg cccgtggacg tggccatgag gctgtgcctg      300

gcccacagcc cccccgtgaa aagcttcctg ggcccctacg acgagttcca gaggaggcac      360

ttcgtcaaca agctgaagcc cctgaaaagc tgcctgaaca tcaagcacaa ggccaagagc      420

cagaacgact ggaagtgcag ccacaaccag gccaagaaaa gggtggtgtt cgccgacagc      480

aagggcctga gcctgaccgc catccacgtc ttcagcgacc tccccgagga gcccggcgcc      540

gccggagagc aggacaacag cccccagaag atccagttca ccgtgcccct gctggagccc      600

cacctggacc ccgaggccgc cgagcagatc aggaggagga ggcccgagcc cgccaccctg      660

gtgctgacca gcgaccagag cagccccgag atcgacgagg acaggattcc caacccccac      720

ctgaaaagca ccctggccat ggaccccagg cagaggaaga agatggagag gatcaccccc      780

accatgaagg agctgcagat gatggtggag caccacctgg gccagcagca gcagggcgag      840

gag                                                                    843


<210>  27
<211>  877
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  27
gctagcgccg gcggcgaccc caaccagctg accaggaagg gcaggaaaag gaaaagcgtg       60

acctggcccg aggagggcaa gctgagggag tacttctact tcgagctgga cgagaccgag      120

agggtgaacg tgaacaagat caaggacttc ggcgaggccg ccaagaggga gatcctgagc      180

gacaggcacg ccttcgagac cgccaggagg cccggcggcg ccggaagctg caccaggatg      240

atccaggtgc tggaccccag gcccctgacc agcagcgtga tgcccgtgga cgtggccatg      300

aggctgtgcc tggcccacag cccccccgtg aaaagcttcc tgggccccta cgacgagttc      360

cagaggaggc acttcgtcaa caagctgaag cccctgaaaa gctgcctgaa catcaagcac      420

aaggccaaga gccagaacga ctggaagtgc agccacaacc aggccaagaa aagggtggtg      480

ttcgccgaca gcaagggcct gagcctgacc gccatccacg tcttcagcga cctccccgag      540

gagcccggcg ccgccggaga gcaggacaac agcccccaga agatccagtt caccgtgccc      600

ctgctggagc cccacctgga ccccgaggcc gccgagcaga tcaggaggag gaggcccgag      660

cccgccaccc tggtgctgac cagcgaccag agcagccccg agatcgacga ggacaggatt      720

cccaaccccc acctgaaaag caccctggcc atggacccca ggcagaggaa gaagatggag      780

aggatcaccc ccaccatgaa ggagctgcag atgatggtgg agcaccacct gggccagcag      840

cagcagggcg aggagcccgg gggaggcgga atcgatt                               877


<210>  28
<211>  886
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  28
gctagcgcca ccatggccgg cggcgacccc aaccagctga ccaggaaggg caggaaaagg       60

aaaagcgtga cctggcccga ggagggcaag ctgagggagt acttctactt cgagctggac      120

gagaccgaga gggtgaacgt gaacaagatc aaggacttcg gcgaggccgc caagagggag      180

atcctgagcg acaggcacgc cttcgagacc gccaggaggc ccggcggcgc cggaagctgc      240

accaggatga tccaggtgct ggaccccagg cccctgacca gcagcgtgat gcccgtggac      300

gtggccatga ggctgtgcct ggcccacagc ccccccgtga aaagcttcct gggcccctac      360

gacgagttcc agaggaggca cttcgtcaac aagctgaagc ccctgaaaag ctgcctgaac      420

atcaagcaca aggccaagag ccagaacgac tggaagtgca gccacaacca ggccaagaaa      480

agggtggtgt tcgccgacag caagggcctg agcctgaccg ccatccacgt cttcagcgac      540

ctccccgagg agcccggcgc cgccggagag caggacaaca gcccccagaa gatccagttc      600

accgtgcccc tgctggagcc ccacctggac cccgaggccg ccgagcagat caggaggagg      660

aggcccgagc ccgccaccct ggtgctgacc agcgaccaga gcagccccga gatcgacgag      720

gacaggattc ccaaccccca cctgaaaagc accctggcca tggaccccag gcagaggaag      780

aagatggaga ggatcacccc caccatgaag gagctgcaga tgatggtgga gcaccacctg      840

ggccagcagc agcagggcga ggagcccggg ggaggcggaa tcgatt                     886


<210>  29
<211>  246
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  29

Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu Leu 
1               5                   10                  15      


Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro Glu 
        35                  40                  45              


Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu Ala 
    50                  55                  60                  


Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Ile Thr Pro Thr Met 
65                  70                  75                  80  


Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln Gln 
                85                  90                  95      


Gly Glu Glu Pro Gly Gly Ala Gly Glu Glu Pro Gln Ser Asp Pro Ser 
            100                 105                 110         


Val Glu Pro Pro Leu Ser Gln Glu Thr Phe Ser Asp Leu Trp Lys Leu 
        115                 120                 125             


Leu Pro Glu Asn Asn Val Leu Ser Pro Leu Pro Ser Gln Ala Met Asp 
    130                 135                 140                 


Asp Leu Met Leu Ser Pro Asp Asp Ile Glu Gln Trp Phe Thr Glu Asp 
145                 150                 155                 160 


Pro Gly Pro Pro Gly Ala Ala Gly Arg Lys Leu Asn Gln Arg Pro Val 
                165                 170                 175     


Asp Glu Leu Arg Asp Arg Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val 
            180                 185                 190         


Glu Val Ala Lys Ala Gln Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp 
        195                 200                 205             


Thr Arg Leu Ser Ala Ala Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn 
    210                 215                 220                 


Glu Tyr Lys Ser Asn Glu Met Glu Val His Ala Ser Ser Lys His Leu 
225                 230                 235                 240 


Thr Arg Phe His Arg Pro 
                245     


<210>  30
<211>  738
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  30
gagcaggaca acagccccca gaagatccag ttcaccgtgc ccctgctgga gccccacctg       60

gaccccgagg ccgccgagca gatcaggagg aggaggccca cccccgccac cctggtgctg      120

accagcgacc agagcagccc cgagatcgac gaggacagga ttcccaaccc ccacctgaaa      180

agcaccctgg ccatgagccc caggcagagg aagaagatga ccaggatcac ccccaccatg      240

aaggagctgc agatgatggt ggagcaccac ctgggccagc agcagcaggg cgaggagccc      300

ggcggcgccg gagaggagcc ccagagcgac cccagcgtgg agccccccct gagccaggag      360

accttcagcg acctgtggaa gctgctgccc gagaacaacg tgctgagccc cctgcccagc      420

caggccatgg acgacctgat gctgagcccc gacgacatcg agcagtggtt caccgaggac      480

cccggccccc ccggagccgc cggaaggaag ctgaaccaga ggcccgtgga cgagctgagg      540

gacaggaaga tcctgatcag gttcagcgac tacgtggagg tggccaaggc ccaggactac      600

gacaggaggg ccgacaagcc ctggaccagg ctgagcgccg ccgacaaagc cgccatcagg      660

aaggagctga acgagtacaa gagcaacgag atggaggtcc acgccagcag caagcacctg      720

accaggttcc acaggccc                                                    738


<210>  31
<211>  772
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  31
gctagcgccg gcgagcagga caacagcccc cagaagatcc agttcaccgt gcccctgctg       60

gagccccacc tggaccccga ggccgccgag cagatcagga ggaggaggcc cacccccgcc      120

accctggtgc tgaccagcga ccagagcagc cccgagatcg acgaggacag gattcccaac      180

ccccacctga aaagcaccct ggccatgagc cccaggcaga ggaagaagat gaccaggatc      240

acccccacca tgaaggagct gcagatgatg gtggagcacc acctgggcca gcagcagcag      300

ggcgaggagc ccggcggcgc cggagaggag ccccagagcg accccagcgt ggagcccccc      360

ctgagccagg agaccttcag cgacctgtgg aagctgctgc ccgagaacaa cgtgctgagc      420

cccctgccca gccaggccat ggacgacctg atgctgagcc ccgacgacat cgagcagtgg      480

ttcaccgagg accccggccc ccccggagcc gccggaagga agctgaacca gaggcccgtg      540

gacgagctga gggacaggaa gatcctgatc aggttcagcg actacgtgga ggtggccaag      600

gcccaggact acgacaggag ggccgacaag ccctggacca ggctgagcgc cgccgacaaa      660

gccgccatca ggaaggagct gaacgagtac aagagcaacg agatggaggt ccacgccagc      720

agcaagcacc tgaccaggtt ccacaggccc cccgggggag gcggaatcga tt              772


<210>  32
<211>  781
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  32
gctagcgcca ccatggccgg cgagcaggac aacagccccc agaagatcca gttcaccgtg       60

cccctgctgg agccccacct ggaccccgag gccgccgagc agatcaggag gaggaggccc      120

acccccgcca ccctggtgct gaccagcgac cagagcagcc ccgagatcga cgaggacagg      180

attcccaacc cccacctgaa aagcaccctg gccatgagcc ccaggcagag gaagaagatg      240

accaggatca cccccaccat gaaggagctg cagatgatgg tggagcacca cctgggccag      300

cagcagcagg gcgaggagcc cggcggcgcc ggagaggagc cccagagcga ccccagcgtg      360

gagccccccc tgagccagga gaccttcagc gacctgtgga agctgctgcc cgagaacaac      420

gtgctgagcc ccctgcccag ccaggccatg gacgacctga tgctgagccc cgacgacatc      480

gagcagtggt tcaccgagga ccccggcccc cccggagccg ccggaaggaa gctgaaccag      540

aggcccgtgg acgagctgag ggacaggaag atcctgatca ggttcagcga ctacgtggag      600

gtggccaagg cccaggacta cgacaggagg gccgacaagc cctggaccag gctgagcgcc      660

gccgacaaag ccgccatcag gaaggagctg aacgagtaca agagcaacga gatggaggtc      720

cacgccagca gcaagcacct gaccaggttc cacaggcccc ccgggggagg cggaatcgat      780

t                                                                      781


<210>  33
<211>  300
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  33

Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Asp Thr 
1               5                   10                  15      


Ile Glu Met Pro Gln Gln Ala Pro Gly Gly Ala Gly Glu Gln Asp Asn 
            20                  25                  30          


Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu Leu Glu Pro His Leu 
        35                  40                  45              


Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg Pro Glu Pro Ala 
    50                  55                  60                  


Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro Glu Ile Asp Glu Asp 
65                  70                  75                  80  


Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu Ala Pro Gly Ala Ala 
                85                  90                  95      


Gly Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys 
            100                 105                 110         


Asn Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro 
        115                 120                 125             


Arg Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp 
    130                 135                 140                 


Glu Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Leu 
145                 150                 155                 160 


Met Lys Ile Asp Glu Pro Ser Glu Pro Tyr His Ser Met Met Gly Asp 
                165                 170                 175     


Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala Pro 
            180                 185                 190         


Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro Lys 
        195                 200                 205             


Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp Leu 
    210                 215                 220                 


Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg Lys 
225                 230                 235                 240 


Leu His Tyr Asn Glu Gly Leu Asn Ile Lys Leu Ala Arg Gln Leu Ile 
                245                 250                 255     


Ser Lys Asp Leu His Asp Asp Asp Glu Asp Glu Glu Met Leu Glu Thr 
            260                 265                 270         


Ala Asp Gly Glu Ser Met Asn Thr Glu Glu Ser Asn Gln Gly Ser Thr 
        275                 280                 285             


Pro Ser Asp Gln Gln Gln Asn Lys Leu Arg Ser Ser 
    290                 295                 300 


<210>  34
<211>  900
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  34
gagaaggtgc agtacctgac caggagcgcc atcaggaggg ccgacaccat cgagatgccc       60

cagcaggccc ccggcggcgc cggagagcag gacaacagcc cccagaagat ccagttcacc      120

gtgcccctgc tggagcccca cctggacccc gaggccgccg agcagatcag gaggaggagg      180

cccgagcccg ccaccctggt gctgaccagc gaccagagca gccccgagat cgacgaggac      240

aggattccca acccccacct gaaaagcacc ctggcccccg gcgccgccgg agccgccagc      300

accgccagcc acaggcccat caagggcatc ctgaagaaca agaccagcac cacctccagc      360

atggtcgcca gcgccgagca gcccaggggc aacgtggacg aggagctgag caagaaaagc      420

cagaagtggg acgagatgaa catcctggcc acctaccacc ccgccgacaa ggactacctg      480

atgaagatcg acgagcccag cgagccctac cacagcatga tgggcgacga cgaggacgcc      540

tgcagcgaca ccgaggccac cgaagccatg gcccccgaca tcctggccag gaagctcgcc      600

gccgccgagg gcctggagcc caagtacagg attcaggagc aggagagcag cggcgaggag      660

gacagcgacc tgagccccga ggagagggag aagaaaaggc agttcgagat gaaaaggaag      720

ctgcactaca acgagggcct gaacatcaag ctggccaggc agctgatcag caaggacctc      780

cacgacgacg acgaggacga ggagatgctg gagaccgccg acggcgagag catgaacacc      840

gaggagagca accagggcag cacccccagc gaccagcagc agaacaagct gaggagcagc      900


<210>  35
<211>  934
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  35
gctagcgccg gcgagaaggt gcagtacctg accaggagcg ccatcaggag ggccgacacc       60

atcgagatgc cccagcaggc ccccggcggc gccggagagc aggacaacag cccccagaag      120

atccagttca ccgtgcccct gctggagccc cacctggacc ccgaggccgc cgagcagatc      180

aggaggagga ggcccgagcc cgccaccctg gtgctgacca gcgaccagag cagccccgag      240

atcgacgagg acaggattcc caacccccac ctgaaaagca ccctggcccc cggcgccgcc      300

ggagccgcca gcaccgccag ccacaggccc atcaagggca tcctgaagaa caagaccagc      360

accacctcca gcatggtcgc cagcgccgag cagcccaggg gcaacgtgga cgaggagctg      420

agcaagaaaa gccagaagtg ggacgagatg aacatcctgg ccacctacca ccccgccgac      480

aaggactacc tgatgaagat cgacgagccc agcgagccct accacagcat gatgggcgac      540

gacgaggacg cctgcagcga caccgaggcc accgaagcca tggcccccga catcctggcc      600

aggaagctcg ccgccgccga gggcctggag cccaagtaca ggattcagga gcaggagagc      660

agcggcgagg aggacagcga cctgagcccc gaggagaggg agaagaaaag gcagttcgag      720

atgaaaagga agctgcacta caacgagggc ctgaacatca agctggccag gcagctgatc      780

agcaaggacc tccacgacga cgacgaggac gaggagatgc tggagaccgc cgacggcgag      840

agcatgaaca ccgaggagag caaccagggc agcaccccca gcgaccagca gcagaacaag      900

ctgaggagca gccccggggg aggcggaatc gatt                                  934


<210>  36
<211>  943
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  36
gctagcgcca ccatggccgg cgagaaggtg cagtacctga ccaggagcgc catcaggagg       60

gccgacacca tcgagatgcc ccagcaggcc cccggcggcg ccggagagca ggacaacagc      120

ccccagaaga tccagttcac cgtgcccctg ctggagcccc acctggaccc cgaggccgcc      180

gagcagatca ggaggaggag gcccgagccc gccaccctgg tgctgaccag cgaccagagc      240

agccccgaga tcgacgagga caggattccc aacccccacc tgaaaagcac cctggccccc      300

ggcgccgccg gagccgccag caccgccagc cacaggccca tcaagggcat cctgaagaac      360

aagaccagca ccacctccag catggtcgcc agcgccgagc agcccagggg caacgtggac      420

gaggagctga gcaagaaaag ccagaagtgg gacgagatga acatcctggc cacctaccac      480

cccgccgaca aggactacct gatgaagatc gacgagccca gcgagcccta ccacagcatg      540

atgggcgacg acgaggacgc ctgcagcgac accgaggcca ccgaagccat ggcccccgac      600

atcctggcca ggaagctcgc cgccgccgag ggcctggagc ccaagtacag gattcaggag      660

caggagagca gcggcgagga ggacagcgac ctgagccccg aggagaggga gaagaaaagg      720

cagttcgaga tgaaaaggaa gctgcactac aacgagggcc tgaacatcaa gctggccagg      780

cagctgatca gcaaggacct ccacgacgac gacgaggacg aggagatgct ggagaccgcc      840

gacggcgaga gcatgaacac cgaggagagc aaccagggca gcacccccag cgaccagcag      900

cagaacaagc tgaggagcag ccccggggga ggcggaatcg att                        943


<210>  37
<211>  300
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  37

Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Glu Thr 
1               5                   10                  15      


Ile Glu Met Pro Gln Gln Ala Pro Gly Gly Ala Gly Glu Gln Asp Asn 
            20                  25                  30          


Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu Leu Glu Pro His Leu 
        35                  40                  45              


Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg Pro Glu Pro Ala 
    50                  55                  60                  


Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro Glu Ile Asp Glu Asp 
65                  70                  75                  80  


Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu Ala Pro Gly Ala Ala 
                85                  90                  95      


Gly Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys 
            100                 105                 110         


Asn Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro 
        115                 120                 125             


Arg Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp 
    130                 135                 140                 


Glu Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Leu 
145                 150                 155                 160 


Met Lys Ile Asp Glu Pro Ser Glu Pro Tyr His Ser Met Met Gly Asp 
                165                 170                 175     


Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala Pro 
            180                 185                 190         


Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro Lys 
        195                 200                 205             


Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp Leu 
    210                 215                 220                 


Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg Lys 
225                 230                 235                 240 


Leu His Tyr Asn Glu Gly Leu Asn Ile Lys Leu Ala Arg Gln Leu Ile 
                245                 250                 255     


Ser Lys Asp Leu His Asp Asp Asp Glu Asp Glu Glu Met Leu Glu Thr 
            260                 265                 270         


Ala Asp Gly Glu Ser Met Asn Thr Glu Glu Ser Asn Gln Gly Ser Thr 
        275                 280                 285             


Pro Ser Asp Gln Gln Gln Asn Lys Leu Arg Ser Ser 
    290                 295                 300 


<210>  38
<211>  900
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  38
gagaaggtgc agtacctgac caggagcgcc atcaggaggg ccgagaccat cgagatgccc       60

cagcaggccc ccggcggcgc cggagagcag gacaacagcc cccagaagat ccagttcacc      120

gtgcccctgc tggagcccca cctggacccc gaggccgccg agcagatcag gaggaggagg      180

cccgagcccg ccaccctggt gctgaccagc gaccagagca gccccgagat cgacgaggac      240

aggattccca acccccacct gaaaagcacc ctggcccccg gcgccgccgg agccgccagc      300

accgccagcc acaggcccat caagggcatc ctgaagaaca agaccagcac cacctccagc      360

atggtcgcca gcgccgagca gcccaggggc aacgtggacg aggagctgag caagaaaagc      420

cagaagtggg acgagatgaa catcctggcc acctaccacc ccgccgacaa ggactacctg      480

atgaagatcg acgagcccag cgagccctac cacagcatga tgggcgacga cgaggacgcc      540

tgcagcgaca ccgaggccac cgaagccatg gcccccgaca tcctggccag gaagctcgcc      600

gccgccgagg gcctggagcc caagtacagg attcaggagc aggagagcag cggcgaggag      660

gacagcgacc tgagccccga ggagagggag aagaaaaggc agttcgagat gaaaaggaag      720

ctgcactaca acgagggcct gaacatcaag ctggccaggc agctgatcag caaggacctc      780

cacgacgacg acgaggacga ggagatgctg gagaccgccg acggcgagag catgaacacc      840

gaggagagca accagggcag cacccccagc gaccagcagc agaacaagct gaggagcagc      900


<210>  39
<211>  934
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  39
gctagcgccg gcgagaaggt gcagtacctg accaggagcg ccatcaggag ggccgagacc       60

atcgagatgc cccagcaggc ccccggcggc gccggagagc aggacaacag cccccagaag      120

atccagttca ccgtgcccct gctggagccc cacctggacc ccgaggccgc cgagcagatc      180

aggaggagga ggcccgagcc cgccaccctg gtgctgacca gcgaccagag cagccccgag      240

atcgacgagg acaggattcc caacccccac ctgaaaagca ccctggcccc cggcgccgcc      300

ggagccgcca gcaccgccag ccacaggccc atcaagggca tcctgaagaa caagaccagc      360

accacctcca gcatggtcgc cagcgccgag cagcccaggg gcaacgtgga cgaggagctg      420

agcaagaaaa gccagaagtg ggacgagatg aacatcctgg ccacctacca ccccgccgac      480

aaggactacc tgatgaagat cgacgagccc agcgagccct accacagcat gatgggcgac      540

gacgaggacg cctgcagcga caccgaggcc accgaagcca tggcccccga catcctggcc      600

aggaagctcg ccgccgccga gggcctggag cccaagtaca ggattcagga gcaggagagc      660

agcggcgagg aggacagcga cctgagcccc gaggagaggg agaagaaaag gcagttcgag      720

atgaaaagga agctgcacta caacgagggc ctgaacatca agctggccag gcagctgatc      780

agcaaggacc tccacgacga cgacgaggac gaggagatgc tggagaccgc cgacggcgag      840

agcatgaaca ccgaggagag caaccagggc agcaccccca gcgaccagca gcagaacaag      900

ctgaggagca gccccggggg aggcggaatc gatt                                  934


<210>  40
<211>  943
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  40
gctagcgcca ccatggccgg cgagaaggtg cagtacctga ccaggagcgc catcaggagg       60

gccgagacca tcgagatgcc ccagcaggcc cccggcggcg ccggagagca ggacaacagc      120

ccccagaaga tccagttcac cgtgcccctg ctggagcccc acctggaccc cgaggccgcc      180

gagcagatca ggaggaggag gcccgagccc gccaccctgg tgctgaccag cgaccagagc      240

agccccgaga tcgacgagga caggattccc aacccccacc tgaaaagcac cctggccccc      300

ggcgccgccg gagccgccag caccgccagc cacaggccca tcaagggcat cctgaagaac      360

aagaccagca ccacctccag catggtcgcc agcgccgagc agcccagggg caacgtggac      420

gaggagctga gcaagaaaag ccagaagtgg gacgagatga acatcctggc cacctaccac      480

cccgccgaca aggactacct gatgaagatc gacgagccca gcgagcccta ccacagcatg      540

atgggcgacg acgaggacgc ctgcagcgac accgaggcca ccgaagccat ggcccccgac      600

atcctggcca ggaagctcgc cgccgccgag ggcctggagc ccaagtacag gattcaggag      660

caggagagca gcggcgagga ggacagcgac ctgagccccg aggagaggga gaagaaaagg      720

cagttcgaga tgaaaaggaa gctgcactac aacgagggcc tgaacatcaa gctggccagg      780

cagctgatca gcaaggacct ccacgacgac gacgaggacg aggagatgct ggagaccgcc      840

gacggcgaga gcatgaacac cgaggagagc aaccagggca gcacccccag cgaccagcag      900

cagaacaagc tgaggagcag ccccggggga ggcggaatcg att                        943


<210>  41
<211>  249
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  41

Glu Asp Asp Glu Leu Lys Gly Leu Leu Gly Leu Pro Glu Glu Glu Thr 
1               5                   10                  15      


Glu Leu Asp Asn Leu Thr Glu Phe Asn Thr Ala His Asn Lys Arg Ile 
            20                  25                  30          


Ser Thr Leu Thr Ile Glu Glu Gly Asn Leu Asp Ile Gln Arg Pro Lys 
        35                  40                  45              


Arg Lys Arg Lys Asn Ser Arg Val Thr Phe Ser Glu Asp Asp Glu Ile 
    50                  55                  60                  


Ile Asn Pro Glu Asp Val Asp Pro Ser Val Gly Arg Phe Arg Pro Gly 
65                  70                  75                  80  


Ala Gly Gly Arg Arg Thr Glu Leu Cys Gly Thr Leu Asp Tyr Leu Pro 
                85                  90                  95      


Pro Glu Pro Gly Ala Ala Gly Ala Ala Gln Arg Leu Gly Lys Arg Val 
            100                 105                 110         


Leu Ser Lys Leu Gln Ser Pro Ser Arg Ala Arg Gly Pro Gly Gly Ser 
        115                 120                 125             


Pro Gly Gly Leu Gln Lys Arg His Ala Arg Val Glu Val Lys Tyr Asp 
    130                 135                 140                 


Arg Arg Glu Leu Gln Arg Arg Leu Asp Val Glu Lys Trp Ile Asp Gly 
145                 150                 155                 160 


Arg Leu Glu Glu Leu Tyr Arg Gly Met Glu Ala Asp Met Pro Asp Glu 
                165                 170                 175     


Ile Asn Ile Asp Glu Leu Leu Glu Leu Glu Ser Glu Glu Glu Arg Ser 
            180                 185                 190         


Arg Lys Ile Gln Gly Leu Leu Lys Ser Cys Gly Lys Pro Val Glu Asp 
        195                 200                 205             


Phe Ile Gln Glu Leu Leu Ala Lys Leu Gln Gly Leu His Arg Gln Pro 
    210                 215                 220                 


Gly Leu Arg Gln Pro Ser Pro Ser His Asp Gly Ser Leu Ser Pro Leu 
225                 230                 235                 240 


Gln Asp Arg Ala Arg Thr Ala His Pro 
                245                 


<210>  42
<211>  747
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  42
gaggacgacg agctgaaggg cctgctggga ctgcccgagg aggagaccga gctggacaac       60

ctgaccgagt tcaacaccgc ccacaacaag aggatcagca ccctgaccat cgaggagggc      120

aacctggaca tccagaggcc caagaggaaa aggaagaaca gcagggtgac cttcagcgag      180

gacgacgaga tcatcaaccc cgaggacgtg gaccccagcg tgggcagatt caggcccggc      240

gccggaggca ggaggaccga gctgtgcggc accctggact acctcccccc cgagcccggc      300

gccgccggag ccgcccagag gctgggcaag agggtgctga gcaagctgca gagccccagc      360

agggccaggg gccccggcgg aagccccggc ggactgcaga aaaggcacgc cagggtggag      420

gtgaagtacg acaggaggga gctgcagagg aggctggacg tggagaagtg gatcgacggc      480

aggctggagg agctgtacag gggcatggag gccgacatgc ccgacgagat caacatcgac      540

gagctgctgg agctggagag cgaggaggag aggagcagga agatccaggg cctgctgaaa      600

agctgcggca agcccgtgga ggacttcatc caggagctgc tggccaagct gcagggcctc      660

cacaggcagc ccggcctgag gcagcccagc cccagccacg acggaagcct gagccccctg      720

caagacaggg ccaggaccgc ccacccc                                          747


<210>  43
<211>  781
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  43
gctagcgccg gcgaggacga cgagctgaag ggcctgctgg gactgcccga ggaggagacc       60

gagctggaca acctgaccga gttcaacacc gcccacaaca agaggatcag caccctgacc      120

atcgaggagg gcaacctgga catccagagg cccaagagga aaaggaagaa cagcagggtg      180

accttcagcg aggacgacga gatcatcaac cccgaggacg tggaccccag cgtgggcaga      240

ttcaggcccg gcgccggagg caggaggacc gagctgtgcg gcaccctgga ctacctcccc      300

cccgagcccg gcgccgccgg agccgcccag aggctgggca agagggtgct gagcaagctg      360

cagagcccca gcagggccag gggccccggc ggaagccccg gcggactgca gaaaaggcac      420

gccagggtgg aggtgaagta cgacaggagg gagctgcaga ggaggctgga cgtggagaag      480

tggatcgacg gcaggctgga ggagctgtac aggggcatgg aggccgacat gcccgacgag      540

atcaacatcg acgagctgct ggagctggag agcgaggagg agaggagcag gaagatccag      600

ggcctgctga aaagctgcgg caagcccgtg gaggacttca tccaggagct gctggccaag      660

ctgcagggcc tccacaggca gcccggcctg aggcagccca gccccagcca cgacggaagc      720

ctgagccccc tgcaagacag ggccaggacc gcccaccccc ccgggggagg cggaatcgat      780

t                                                                      781


<210>  44
<211>  790
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  44
gctagcgcca ccatggccgg cgaggacgac gagctgaagg gcctgctggg actgcccgag       60

gaggagaccg agctggacaa cctgaccgag ttcaacaccg cccacaacaa gaggatcagc      120

accctgacca tcgaggaggg caacctggac atccagaggc ccaagaggaa aaggaagaac      180

agcagggtga ccttcagcga ggacgacgag atcatcaacc ccgaggacgt ggaccccagc      240

gtgggcagat tcaggcccgg cgccggaggc aggaggaccg agctgtgcgg caccctggac      300

tacctccccc ccgagcccgg cgccgccgga gccgcccaga ggctgggcaa gagggtgctg      360

agcaagctgc agagccccag cagggccagg ggccccggcg gaagccccgg cggactgcag      420

aaaaggcacg ccagggtgga ggtgaagtac gacaggaggg agctgcagag gaggctggac      480

gtggagaagt ggatcgacgg caggctggag gagctgtaca ggggcatgga ggccgacatg      540

cccgacgaga tcaacatcga cgagctgctg gagctggaga gcgaggagga gaggagcagg      600

aagatccagg gcctgctgaa aagctgcggc aagcccgtgg aggacttcat ccaggagctg      660

ctggccaagc tgcagggcct ccacaggcag cccggcctga ggcagcccag ccccagccac      720

gacggaagcc tgagccccct gcaagacagg gccaggaccg cccacccccc cgggggaggc      780

ggaatcgatt                                                             790


<210>  45
<211>  372
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  45

Ala Ala Gln Arg Leu Gly Lys Arg Val Leu Ser Lys Leu Gln Ser Pro 
1               5                   10                  15      


Ser Arg Ala Arg Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys Arg 
            20                  25                  30          


His Ala Arg Val Glu Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg 
        35                  40                  45              


Leu Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg 
    50                  55                  60                  


Gly Met Glu Ala Asp Met Pro Asp Glu Ile Asn Ile Asp Glu Leu Leu 
65                  70                  75                  80  


Glu Leu Glu Ser Glu Glu Glu Arg Ser Arg Lys Ile Gln Gly Leu Leu 
                85                  90                  95      


Lys Ser Cys Gly Lys Pro Val Glu Asp Phe Ile Gln Glu Leu Leu Ala 
            100                 105                 110         


Lys Leu Gln Gly Leu His Arg Gln Pro Gly Leu Arg Gln Pro Ser Pro 
        115                 120                 125             


Ser His Asp Gly Ser Leu Ser Pro Leu Gln Asp Arg Ala Arg Thr Ala 
    130                 135                 140                 


His Pro Pro Gly Ala Gly Gly Tyr Glu Pro Thr Ser Pro Ser Tyr Glu 
145                 150                 155                 160 


Pro Thr Ser Pro Ser Tyr Glu Pro Thr Ser Pro Asn Tyr Glu Pro Thr 
                165                 170                 175     


Ser Pro Ser Tyr Glu Pro Thr Ser Pro Ser Tyr Glu Pro Thr Ser Pro 
            180                 185                 190         


Ser Tyr Glu Pro Thr Ser Pro Ser Tyr Glu Pro Thr Ser Pro Ser Tyr 
        195                 200                 205             


Glu Pro Thr Ser Pro Ser Tyr Glu Pro Thr Ser Pro Ser Tyr Glu Pro 
    210                 215                 220                 


Thr Ser Pro Ser Tyr Glu Pro Thr Ser Pro Ser Tyr Glu Pro Thr Ser 
225                 230                 235                 240 


Pro Ser Tyr Glu Pro Thr Ser Pro Ser Tyr Glu Pro Thr Ser Pro Ser 
                245                 250                 255     


Tyr Glu Pro Thr Ser Pro Ser Tyr Glu Pro Thr Pro Gly Ala Ala Gly 
            260                 265                 270         


Gln Thr Leu Pro Ser Ala Val Lys Gly Asp Glu Lys Met Gly Gly Glu 
        275                 280                 285             


Asp Asp Glu Leu Lys Gly Leu Leu Gly Leu Pro Glu Glu Glu Ala Glu 
    290                 295                 300                 


Leu Asp Asn Leu Thr Glu Phe Asn Thr Ala His Asn Lys Arg Ile Ala 
305                 310                 315                 320 


Thr Leu Thr Ile Glu Glu Gly Asn Leu Asp Ile Gln Arg Pro Lys Arg 
                325                 330                 335     


Lys Arg Lys Asn Ala Arg Val Thr Phe Ala Glu Asp Asp Glu Ile Ile 
            340                 345                 350         


Asn Pro Glu Asp Val Asp Pro Ser Val Gly Arg Phe Arg Asn Met Val 
        355                 360                 365             


Gln Thr Ala Val 
    370         


<210>  46
<211>  1116
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  46
gccgcccaga ggctgggcaa gagggtgctg agcaagctgc agagccccag cagggccagg       60

ggccccggcg gaagccccgg cggactgcag aaaaggcacg ccagggtgga ggtgaagtac      120

gacaggaggg agctgcagag gaggctggac gtggagaagt ggatcgacgg caggctggag      180

gagctgtaca ggggcatgga ggccgacatg cccgacgaga tcaacatcga cgagctgctg      240

gagctggaga gcgaggagga gaggagcagg aagatccagg gcctgctgaa aagctgcggc      300

aagcccgtgg aggacttcat ccaggagctg ctggccaagc tgcagggcct ccacaggcag      360

cccggcctga ggcagcccag ccccagccac gacggaagcc tgagccccct gcaagacagg      420

gccaggaccg cccacccccc cggcgccgga ggctacgagc ccaccagccc cagctacgag      480

cccaccagcc ccagctacga gcccaccagc cccaactacg agcccaccag ccccagctac      540

gagcccacca gccccagcta cgagcccacc agccccagct acgagcccac cagccccagc      600

tacgagccca ccagccccag ctacgagccc accagcccca gctacgagcc caccagcccc      660

agctacgagc ccaccagccc cagctacgag cccaccagcc ccagctacga gcccaccagc      720

cccagctacg agcccaccag ccccagctac gagcccacca gccccagcta cgagcccacc      780

agccccagct acgagcccac ccccggcgcc gccggacaga ccctgcccag cgccgtgaag      840

ggcgacgaga agatgggcgg cgaggacgac gagctgaagg gcctgctggg actgcccgag      900

gaggaggccg agctggacaa cctgaccgag ttcaacaccg cccacaacaa gaggatcgcc      960

accctgacca tcgaggaggg caacctggac atccagaggc ccaagaggaa aaggaagaac     1020

gccagggtga ccttcgccga ggacgacgag atcatcaacc ccgaggacgt ggaccccagc     1080

gtgggcagat tcaggaacat ggtgcagacc gccgtg                               1116


<210>  47
<211>  1150
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  47
gctagcgccg gcgccgccca gaggctgggc aagagggtgc tgagcaagct gcagagcccc       60

agcagggcca ggggccccgg cggaagcccc ggcggactgc agaaaaggca cgccagggtg      120

gaggtgaagt acgacaggag ggagctgcag aggaggctgg acgtggagaa gtggatcgac      180

ggcaggctgg aggagctgta caggggcatg gaggccgaca tgcccgacga gatcaacatc      240

gacgagctgc tggagctgga gagcgaggag gagaggagca ggaagatcca gggcctgctg      300

aaaagctgcg gcaagcccgt ggaggacttc atccaggagc tgctggccaa gctgcagggc      360

ctccacaggc agcccggcct gaggcagccc agccccagcc acgacggaag cctgagcccc      420

ctgcaagaca gggccaggac cgcccacccc cccggcgccg gaggctacga gcccaccagc      480

cccagctacg agcccaccag ccccagctac gagcccacca gccccaacta cgagcccacc      540

agccccagct acgagcccac cagccccagc tacgagccca ccagccccag ctacgagccc      600

accagcccca gctacgagcc caccagcccc agctacgagc ccaccagccc cagctacgag      660

cccaccagcc ccagctacga gcccaccagc cccagctacg agcccaccag ccccagctac      720

gagcccacca gccccagcta cgagcccacc agccccagct acgagcccac cagccccagc      780

tacgagccca ccagccccag ctacgagccc acccccggcg ccgccggaca gaccctgccc      840

agcgccgtga agggcgacga gaagatgggc ggcgaggacg acgagctgaa gggcctgctg      900

ggactgcccg aggaggaggc cgagctggac aacctgaccg agttcaacac cgcccacaac      960

aagaggatcg ccaccctgac catcgaggag ggcaacctgg acatccagag gcccaagagg     1020

aaaaggaaga acgccagggt gaccttcgcc gaggacgacg agatcatcaa ccccgaggac     1080

gtggacccca gcgtgggcag attcaggaac atggtgcaga ccgccgtgcc cgggggaggc     1140

ggaatcgatt                                                            1150


<210>  48
<211>  1159
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  48
gctagcgcca ccatggccgg cgccgcccag aggctgggca agagggtgct gagcaagctg       60

cagagcccca gcagggccag gggccccggc ggaagccccg gcggactgca gaaaaggcac      120

gccagggtgg aggtgaagta cgacaggagg gagctgcaga ggaggctgga cgtggagaag      180

tggatcgacg gcaggctgga ggagctgtac aggggcatgg aggccgacat gcccgacgag      240

atcaacatcg acgagctgct ggagctggag agcgaggagg agaggagcag gaagatccag      300

ggcctgctga aaagctgcgg caagcccgtg gaggacttca tccaggagct gctggccaag      360

ctgcagggcc tccacaggca gcccggcctg aggcagccca gccccagcca cgacggaagc      420

ctgagccccc tgcaagacag ggccaggacc gcccaccccc ccggcgccgg aggctacgag      480

cccaccagcc ccagctacga gcccaccagc cccagctacg agcccaccag ccccaactac      540

gagcccacca gccccagcta cgagcccacc agccccagct acgagcccac cagccccagc      600

tacgagccca ccagccccag ctacgagccc accagcccca gctacgagcc caccagcccc      660

agctacgagc ccaccagccc cagctacgag cccaccagcc ccagctacga gcccaccagc      720

cccagctacg agcccaccag ccccagctac gagcccacca gccccagcta cgagcccacc      780

agccccagct acgagcccac cagccccagc tacgagccca cccccggcgc cgccggacag      840

accctgccca gcgccgtgaa gggcgacgag aagatgggcg gcgaggacga cgagctgaag      900

ggcctgctgg gactgcccga ggaggaggcc gagctggaca acctgaccga gttcaacacc      960

gcccacaaca agaggatcgc caccctgacc atcgaggagg gcaacctgga catccagagg     1020

cccaagagga aaaggaagaa cgccagggtg accttcgccg aggacgacga gatcatcaac     1080

cccgaggacg tggaccccag cgtgggcaga ttcaggaaca tggtgcagac cgccgtgccc     1140

gggggaggcg gaatcgatt                                                  1159


<210>  49
<211>  494
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  49

Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys Asn 
1               5                   10                  15      


Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro Arg 
            20                  25                  30          


Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp Glu 
        35                  40                  45              


Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly Leu 
    50                  55                  60                  


Met Lys Ile Asp Glu Pro Ser Glu Pro Tyr His Ser Met Met Gly Asp 
65                  70                  75                  80  


Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala Pro 
                85                  90                  95      


Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro Lys 
            100                 105                 110         


Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp Leu 
        115                 120                 125             


Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg Lys 
    130                 135                 140                 


Leu His Tyr Asn Glu Pro Gly Ala Gly Gly Ser Thr Glu Leu Phe Ser 
145                 150                 155                 160 


Ser Thr Arg Glu Glu Gly Ser Ser Gly Ser Gly Pro Ser Phe Arg Ser 
                165                 170                 175     


Asn Gln Arg Lys Met Leu Asn Leu Leu Leu Glu Arg Asp Thr Ser Phe 
            180                 185                 190         


Thr Val Cys Pro Asp Val Pro Arg Glu Pro Val Gly Lys Phe Leu Gly 
        195                 200                 205             


Asp Ser Ala Asn Leu Ser Ile Leu Ser Gly Gly Glu Pro Lys Cys Cys 
    210                 215                 220                 


Leu Asp Leu Ser Asn Leu Ser Ser Gly Glu Ile Thr Ala Thr Gln Leu 
225                 230                 235                 240 


Thr Thr Ser Ala Asp Leu Asp Glu Thr Gly His Leu Asp Ser Ser Gly 
                245                 250                 255     


Leu Gln Glu Val His Leu Ala Gly Met Asn His Asp Gln His Leu Met 
            260                 265                 270         


Lys Cys Asp Pro Ala Gln Leu Leu Cys Ser Glu Pro Asn Gly Leu Asp 
        275                 280                 285             


Arg Gly His Arg Lys Arg Asp Ala Met Cys Ser Ser Ser Ala Asn Lys 
    290                 295                 300                 


Glu Asn Asp Asn Gly Asn Leu Val Asp Ser Glu Met Lys Tyr Leu Gly 
305                 310                 315                 320 


Asp Pro Ile Thr Thr Val Pro Lys Leu Asp Lys Asn Pro Asn Leu Gly 
                325                 330                 335     


Glu Asp Gln Ala Glu Glu Ile Asp Asp Glu Leu Met Glu Phe Asp Leu 
            340                 345                 350         


Lys Asp Gln Glu Ala Lys Val Ser Arg Ser Gly Leu Tyr Arg Asp Pro 
        355                 360                 365             


Asp Met Pro Glu Asn Leu Asn Arg Pro Arg Leu Lys Gln Val Glu Lys 
    370                 375                 380                 


Phe Lys Asp Asn Thr Ile Pro Gly Ala Ala Gly Glu Asp Ser Asn Asn 
385                 390                 395                 400 


Phe Asp Gly Ser His Val Tyr Met His Ser Asp Tyr Asn Val Tyr Arg 
                405                 410                 415     


Val Arg Ser Arg Tyr Asn Ser Asp Trp Gly Glu Thr Gly Thr Glu Gln 
            420                 425                 430         


Asp Glu Glu Glu Asp Ser Asp Glu Asn Ser Tyr Tyr Gln Pro Asp Met 
        435                 440                 445             


Glu Tyr Ser Glu Ile Val Gly Leu Pro Glu Glu Glu Glu Ile Pro Ala 
    450                 455                 460                 


Asn Arg Lys Ile Lys Phe Ser Ser Ala Pro Ile Lys Val Phe Asn Thr 
465                 470                 475                 480 


Tyr Ser Asn Glu Asp Tyr Asp Arg Arg Asn Asp Glu Val Asp 
                485                 490                 


<210>  50
<211>  1482
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  50
gccgccagca ccgccagcca caggcccatc aagggcatcc tgaagaacaa gaccagcacc       60

acctccagca tggtcgccag cgccgagcag cccaggggca acgtggacga ggagctgagc      120

aagaaaagcc agaagtggga cgagatgaac atcctggcca cctaccaccc cgccgacaag      180

gactacggcc tgatgaagat cgacgagccc agcgagccct accacagcat gatgggcgac      240

gacgaggacg cctgcagcga caccgaggcc accgaagcca tggcccccga catcctggcc      300

aggaagctcg ccgccgccga gggcctggag cccaagtaca ggattcagga gcaggagagc      360

agcggcgagg aggacagcga cctgagcccc gaggagaggg agaagaaaag gcagttcgag      420

atgaaaagga agctgcacta caacgagccc ggcgccggag gcagcaccga gctgttcagc      480

agcaccaggg aggagggcag cagcggcagc ggccccagct tcaggagcaa ccagaggaag      540

atgctgaacc tcctgctgga gagggacacc agcttcaccg tctgccccga cgtgcccagg      600

gagcccgtgg gcaagttcct gggcgacagc gccaacctga gcatcctgag cggcggcgag      660

cccaagtgct gcctggacct gagcaacctg agcagcggcg agatcaccgc cacccagctg      720

accaccagcg ccgacctgga cgagaccggc cacctggaca gcagcggcct gcaagaggtc      780

catctggccg gaatgaacca cgaccagcac ctgatgaagt gcgaccccgc ccagctgctg      840

tgcagcgagc ccaacggcct cgacaggggc cacaggaaaa gggacgccat gtgcagcagc      900

agcgccaaca aggagaacga caacggcaac ctggtggaca gcgagatgaa gtacctgggc      960

gaccccatca ccaccgtgcc caagctggac aagaacccca acctgggcga ggaccaggcc     1020

gaggagatcg acgacgagct gatggagttc gacctgaagg accaggaggc caaggtgtcc     1080

aggagcggcc tgtacaggga ccccgacatg cccgagaacc tgaacaggcc caggctgaag     1140

caagtcgaga agttcaagga caacaccatc cccggcgccg ccggagagga cagcaacaac     1200

ttcgacggca gccacgtcta catgcacagc gactacaacg tgtacagggt gaggagcaga     1260

tacaacagcg actggggcga gaccggcacc gagcaggacg aggaggagga cagcgacgag     1320

aacagctact accagcccga catggagtac agcgagatcg tgggcctgcc cgaggaggag     1380

gagatccccg ccaacaggaa gatcaagttc agcagcgccc ccatcaaggt gttcaacacc     1440

tacagcaacg aggactacga caggaggaac gacgaggtgg ac                        1482


<210>  51
<211>  1516
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  51
gctagcgccg gcgccgccag caccgccagc cacaggccca tcaagggcat cctgaagaac       60

aagaccagca ccacctccag catggtcgcc agcgccgagc agcccagggg caacgtggac      120

gaggagctga gcaagaaaag ccagaagtgg gacgagatga acatcctggc cacctaccac      180

cccgccgaca aggactacgg cctgatgaag atcgacgagc ccagcgagcc ctaccacagc      240

atgatgggcg acgacgagga cgcctgcagc gacaccgagg ccaccgaagc catggccccc      300

gacatcctgg ccaggaagct cgccgccgcc gagggcctgg agcccaagta caggattcag      360

gagcaggaga gcagcggcga ggaggacagc gacctgagcc ccgaggagag ggagaagaaa      420

aggcagttcg agatgaaaag gaagctgcac tacaacgagc ccggcgccgg aggcagcacc      480

gagctgttca gcagcaccag ggaggagggc agcagcggca gcggccccag cttcaggagc      540

aaccagagga agatgctgaa cctcctgctg gagagggaca ccagcttcac cgtctgcccc      600

gacgtgccca gggagcccgt gggcaagttc ctgggcgaca gcgccaacct gagcatcctg      660

agcggcggcg agcccaagtg ctgcctggac ctgagcaacc tgagcagcgg cgagatcacc      720

gccacccagc tgaccaccag cgccgacctg gacgagaccg gccacctgga cagcagcggc      780

ctgcaagagg tccatctggc cggaatgaac cacgaccagc acctgatgaa gtgcgacccc      840

gcccagctgc tgtgcagcga gcccaacggc ctcgacaggg gccacaggaa aagggacgcc      900

atgtgcagca gcagcgccaa caaggagaac gacaacggca acctggtgga cagcgagatg      960

aagtacctgg gcgaccccat caccaccgtg cccaagctgg acaagaaccc caacctgggc     1020

gaggaccagg ccgaggagat cgacgacgag ctgatggagt tcgacctgaa ggaccaggag     1080

gccaaggtgt ccaggagcgg cctgtacagg gaccccgaca tgcccgagaa cctgaacagg     1140

cccaggctga agcaagtcga gaagttcaag gacaacacca tccccggcgc cgccggagag     1200

gacagcaaca acttcgacgg cagccacgtc tacatgcaca gcgactacaa cgtgtacagg     1260

gtgaggagca gatacaacag cgactggggc gagaccggca ccgagcagga cgaggaggag     1320

gacagcgacg agaacagcta ctaccagccc gacatggagt acagcgagat cgtgggcctg     1380

cccgaggagg aggagatccc cgccaacagg aagatcaagt tcagcagcgc ccccatcaag     1440

gtgttcaaca cctacagcaa cgaggactac gacaggagga acgacgaggt ggaccccggg     1500

ggaggcggaa tcgatt                                                     1516


<210>  52
<211>  1525
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  52
gctagcgcca ccatggccgg cgccgccagc accgccagcc acaggcccat caagggcatc       60

ctgaagaaca agaccagcac cacctccagc atggtcgcca gcgccgagca gcccaggggc      120

aacgtggacg aggagctgag caagaaaagc cagaagtggg acgagatgaa catcctggcc      180

acctaccacc ccgccgacaa ggactacggc ctgatgaaga tcgacgagcc cagcgagccc      240

taccacagca tgatgggcga cgacgaggac gcctgcagcg acaccgaggc caccgaagcc      300

atggcccccg acatcctggc caggaagctc gccgccgccg agggcctgga gcccaagtac      360

aggattcagg agcaggagag cagcggcgag gaggacagcg acctgagccc cgaggagagg      420

gagaagaaaa ggcagttcga gatgaaaagg aagctgcact acaacgagcc cggcgccgga      480

ggcagcaccg agctgttcag cagcaccagg gaggagggca gcagcggcag cggccccagc      540

ttcaggagca accagaggaa gatgctgaac ctcctgctgg agagggacac cagcttcacc      600

gtctgccccg acgtgcccag ggagcccgtg ggcaagttcc tgggcgacag cgccaacctg      660

agcatcctga gcggcggcga gcccaagtgc tgcctggacc tgagcaacct gagcagcggc      720

gagatcaccg ccacccagct gaccaccagc gccgacctgg acgagaccgg ccacctggac      780

agcagcggcc tgcaagaggt ccatctggcc ggaatgaacc acgaccagca cctgatgaag      840

tgcgaccccg cccagctgct gtgcagcgag cccaacggcc tcgacagggg ccacaggaaa      900

agggacgcca tgtgcagcag cagcgccaac aaggagaacg acaacggcaa cctggtggac      960

agcgagatga agtacctggg cgaccccatc accaccgtgc ccaagctgga caagaacccc     1020

aacctgggcg aggaccaggc cgaggagatc gacgacgagc tgatggagtt cgacctgaag     1080

gaccaggagg ccaaggtgtc caggagcggc ctgtacaggg accccgacat gcccgagaac     1140

ctgaacaggc ccaggctgaa gcaagtcgag aagttcaagg acaacaccat ccccggcgcc     1200

gccggagagg acagcaacaa cttcgacggc agccacgtct acatgcacag cgactacaac     1260

gtgtacaggg tgaggagcag atacaacagc gactggggcg agaccggcac cgagcaggac     1320

gaggaggagg acagcgacga gaacagctac taccagcccg acatggagta cagcgagatc     1380

gtgggcctgc ccgaggagga ggagatcccc gccaacagga agatcaagtt cagcagcgcc     1440

cccatcaagg tgttcaacac ctacagcaac gaggactacg acaggaggaa cgacgaggtg     1500

gaccccgggg gaggcggaat cgatt                                           1525


<210>  53
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  53

Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu Leu 
1               5                   10                  15      


Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Glu Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro Glu 
        35                  40                  45              


Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu Ala 
    50                  55                  60                  


Met Asp Pro Arg Gln Arg Lys Lys Met Ala Arg Ile Thr Pro Thr Met 
65                  70                  75                  80  


Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln Gln 
                85                  90                  95      


Gly Glu Glu Pro Gly Ala Gly Gly Val Asn Phe Thr Val Asp Gln Ile 
            100                 105                 110         


Arg Ala Ile Met Asp Lys Lys Ala Asn Ile Arg Asn Met Ser Val Ile 
        115                 120                 125             


Ala His Val Asp His Gly Lys Ser Thr Leu Thr Asp Ser Leu Val Cys 
    130                 135                 140                 


Lys Ala Gly Ile Ile Ala Ser Ala Arg Ala Gly Glu Glu Arg Phe Glu 
145                 150                 155                 160 


Asp Glu Arg Lys Asp Glu Gln Glu Arg Cys Ile Thr Ile Lys Ser Thr 
                165                 170                 175     


Ala Ile Ser Leu Phe Tyr Glu Leu Ser Glu Asn Asp Leu Asn Phe Ile 
            180                 185                 190         


Lys Gln Ser Lys Asp Pro Gly Ala Ala Gly Asp Pro Lys Asp Arg Lys 
        195                 200                 205             


Lys Ile Gln Phe Ser Val Pro Ala Pro Pro Ser Gln Leu Asp Pro Arg 
    210                 215                 220                 


Gln Val Glu Met Ile Arg Arg Arg Arg Pro Glu Pro Ala 
225                 230                 235         


<210>  54
<211>  711
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  54
gagcaggaca acagccccca gaagatccag ttcaccgtgc ccctgctgga gccccacctg       60

gaccccgagg ccgccgagca gatcaggagg aggaggcccg agcccgccac cctggtgctg      120

accagcgacc agagcagccc cgagatcgac gaggacagga ttcccaaccc ccacctgaaa      180

agcaccctgg ccatggaccc caggcagagg aagaagatgg ccaggatcac ccccaccatg      240

aaggagctgc agatgatggt ggagcaccac ctgggccagc agcagcaggg cgaggagccc      300

ggcgccggag gcgtgaactt caccgtggac cagatcaggg ccatcatgga caagaaggcc      360

aacatcagga acatgagcgt gatcgcccac gtcgatcacg gcaagagcac cctgaccgac      420

agcctggtgt gcaaggccgg aatcatcgcc agcgccaggg ccggagagga gaggttcgag      480

gacgagagga aggacgagca ggagaggtgc atcaccatca agagcaccgc catcagcctg      540

ttctacgagc tgagcgagaa cgacctgaac ttcatcaagc agagcaagga ccccggcgcc      600

gccggagacc ccaaggacag gaagaagatc cagttcagcg tgcccgcccc ccccagccag      660

ctcgacccca ggcaagtcga gatgatcagg aggaggaggc ccgagcccgc c               711


<210>  55
<211>  745
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  55
gctagcgccg gcgagcagga caacagcccc cagaagatcc agttcaccgt gcccctgctg       60

gagccccacc tggaccccga ggccgccgag cagatcagga ggaggaggcc cgagcccgcc      120

accctggtgc tgaccagcga ccagagcagc cccgagatcg acgaggacag gattcccaac      180

ccccacctga aaagcaccct ggccatggac cccaggcaga ggaagaagat ggccaggatc      240

acccccacca tgaaggagct gcagatgatg gtggagcacc acctgggcca gcagcagcag      300

ggcgaggagc ccggcgccgg aggcgtgaac ttcaccgtgg accagatcag ggccatcatg      360

gacaagaagg ccaacatcag gaacatgagc gtgatcgccc acgtcgatca cggcaagagc      420

accctgaccg acagcctggt gtgcaaggcc ggaatcatcg ccagcgccag ggccggagag      480

gagaggttcg aggacgagag gaaggacgag caggagaggt gcatcaccat caagagcacc      540

gccatcagcc tgttctacga gctgagcgag aacgacctga acttcatcaa gcagagcaag      600

gaccccggcg ccgccggaga ccccaaggac aggaagaaga tccagttcag cgtgcccgcc      660

ccccccagcc agctcgaccc caggcaagtc gagatgatca ggaggaggag gcccgagccc      720

gcccccgggg gaggcggaat cgatt                                            745


<210>  56
<211>  754
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  56
gctagcgcca ccatggccgg cgagcaggac aacagccccc agaagatcca gttcaccgtg       60

cccctgctgg agccccacct ggaccccgag gccgccgagc agatcaggag gaggaggccc      120

gagcccgcca ccctggtgct gaccagcgac cagagcagcc ccgagatcga cgaggacagg      180

attcccaacc cccacctgaa aagcaccctg gccatggacc ccaggcagag gaagaagatg      240

gccaggatca cccccaccat gaaggagctg cagatgatgg tggagcacca cctgggccag      300

cagcagcagg gcgaggagcc cggcgccgga ggcgtgaact tcaccgtgga ccagatcagg      360

gccatcatgg acaagaaggc caacatcagg aacatgagcg tgatcgccca cgtcgatcac      420

ggcaagagca ccctgaccga cagcctggtg tgcaaggccg gaatcatcgc cagcgccagg      480

gccggagagg agaggttcga ggacgagagg aaggacgagc aggagaggtg catcaccatc      540

aagagcaccg ccatcagcct gttctacgag ctgagcgaga acgacctgaa cttcatcaag      600

cagagcaagg accccggcgc cgccggagac cccaaggaca ggaagaagat ccagttcagc      660

gtgcccgccc cccccagcca gctcgacccc aggcaagtcg agatgatcag gaggaggagg      720

cccgagcccg cccccggggg aggcggaatc gatt                                  754


<210>  57
<211>  403
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (288)..(288)
<223>  Xaa can be any naturally occurring amino acid

<400>  57

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Xaa 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  58
<211>  393
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (215)..(215)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (371)..(371)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (376)..(376)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (378)..(378)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (392)..(392)
<223>  Xaa can be any naturally occurring amino acid

<400>  58

Met Glu Glu Pro Gln Ser Asp Pro Xaa Val Glu Pro Pro Leu Xaa Gln 
1               5                   10                  15      


Glu Xaa Phe Xaa Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Xaa Pro Leu Pro Xaa Gln Ala Met Asp Asp Leu Met Leu Xaa Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Xaa Glu Asp Pro Gly Pro Asp Glu Ala Pro 
    50                  55                  60                  


Arg Met Pro Glu Ala Ala Pro Pro Val Ala Pro Ala Pro Ala Ala Pro 
65                  70                  75                  80  


Thr Pro Ala Ala Pro Ala Pro Ala Pro Ser Trp Pro Leu Ser Ser Ser 
                85                  90                  95      


Val Pro Ser Gln Lys Thr Tyr Gln Gly Ser Tyr Gly Phe Arg Leu Gly 
            100                 105                 110         


Phe Leu His Ser Gly Thr Ala Lys Ser Val Thr Cys Thr Tyr Ser Pro 
        115                 120                 125             


Ala Leu Asn Lys Met Phe Cys Gln Leu Ala Lys Thr Cys Pro Val Gln 
    130                 135                 140                 


Leu Trp Val Asp Ser Thr Pro Pro Pro Gly Thr Arg Val Arg Ala Met 
145                 150                 155                 160 


Ala Ile Tyr Lys Gln Ser Gln His Met Thr Glu Val Val Arg Arg Cys 
                165                 170                 175     


Pro His His Glu Arg Cys Ser Asp Ser Asp Gly Leu Ala Pro Pro Gln 
            180                 185                 190         


His Leu Ile Arg Val Glu Gly Asn Leu Arg Val Glu Tyr Leu Asp Asp 
        195                 200                 205             


Arg Asn Thr Phe Arg His Xaa Val Val Val Pro Tyr Glu Pro Pro Glu 
    210                 215                 220                 


Val Gly Ser Asp Cys Thr Thr Ile His Tyr Asn Tyr Met Cys Asn Ser 
225                 230                 235                 240 


Ser Cys Met Gly Gly Met Asn Arg Arg Pro Ile Leu Thr Ile Ile Thr 
                245                 250                 255     


Leu Glu Asp Ser Ser Gly Asn Leu Leu Gly Arg Asn Ser Phe Glu Val 
            260                 265                 270         


Arg Val Cys Ala Cys Pro Gly Arg Asp Arg Arg Thr Glu Glu Glu Asn 
        275                 280                 285             


Leu Arg Lys Lys Gly Glu Pro His His Glu Leu Pro Pro Gly Ser Thr 
    290                 295                 300                 


Lys Arg Ala Leu Pro Asn Asn Thr Ser Ser Ser Pro Gln Pro Lys Lys 
305                 310                 315                 320 


Lys Pro Leu Asp Gly Glu Tyr Phe Thr Leu Gln Ile Arg Gly Arg Glu 
                325                 330                 335     


Arg Phe Glu Met Phe Arg Glu Leu Asn Glu Ala Leu Glu Leu Lys Asp 
            340                 345                 350         


Ala Gln Ala Gly Lys Glu Pro Gly Gly Ser Arg Ala His Ser Ser His 
        355                 360                 365             


Leu Lys Xaa Lys Lys Gly Gln Xaa Thr Xaa Arg His Lys Lys Leu Met 
    370                 375                 380                 


Phe Lys Thr Glu Gly Pro Asp Xaa Asp 
385                 390             


<210>  59
<211>  1030
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  59

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
1               5                   10                  15      


Trp Ile Gly Xaa Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
            20                  25                  30          


Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
        35                  40                  45              


Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
    50                  55                  60                  


Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
65                  70                  75                  80  


Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                85                  90                  95      


Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
            100                 105                 110         


Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
        115                 120                 125             


Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
    130                 135                 140                 


Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
145                 150                 155                 160 


Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                165                 170                 175     


Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
            180                 185                 190         


Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
        195                 200                 205             


Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
    210                 215                 220                 


Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
225                 230                 235                 240 


His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                245                 250                 255     


Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
            260                 265                 270         


Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
        275                 280                 285             


Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
    290                 295                 300                 


Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
305                 310                 315                 320 


Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                325                 330                 335     


Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
            340                 345                 350         


Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
        355                 360                 365             


Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
    370                 375                 380                 


Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                405                 410                 415     


Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
            420                 425                 430         


Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
        435                 440                 445             


Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
    450                 455                 460                 


Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
465                 470                 475                 480 


Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                485                 490                 495     


Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
            500                 505                 510         


Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
        515                 520                 525             


Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
    530                 535                 540                 


Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
545                 550                 555                 560 


Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                565                 570                 575     


Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
            580                 585                 590         


Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
        595                 600                 605             


Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
    610                 615                 620                 


Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
625                 630                 635                 640 


Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                645                 650                 655     


Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
            660                 665                 670         


Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
        675                 680                 685             


Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
    690                 695                 700                 


Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
705                 710                 715                 720 


Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                725                 730                 735     


Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
            740                 745                 750         


Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
        755                 760                 765             


Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
    770                 775                 780                 


Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
785                 790                 795                 800 


Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                805                 810                 815     


Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
            820                 825                 830         


Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
        835                 840                 845             


Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
    850                 855                 860                 


Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
865                 870                 875                 880 


Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                885                 890                 895     


Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
            900                 905                 910         


Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
        915                 920                 925             


Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
    930                 935                 940                 


Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                965                 970                 975     


Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
            980                 985                 990         


Arg Ile Ser Glu Met Glu Glu Glu  Leu Lys Met Leu Pro  Asp Leu Lys 
        995                 1000                 1005             


Ala Asp  Asn Gln Arg Leu Lys  Asp Glu Asn Gly Ala  Leu Ile Arg 
    1010                 1015                 1020             


Val Ile  Ser Lys Leu Ser Lys  
    1025                 1030 


<210>  60
<211>  1970
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1562)..(1562)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1594)..(1594)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1616)..(1616)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1623)..(1623)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1630)..(1630)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1637)..(1637)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1644)..(1644)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1651)..(1651)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1658)..(1658)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1665)..(1665)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1672)..(1672)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1686)..(1686)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1693)..(1693)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1700)..(1700)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1707)..(1707)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1714)..(1714)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1721)..(1721)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1728)..(1728)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1735)..(1735)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1742)..(1742)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1749)..(1749)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1763)..(1763)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1770)..(1770)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1784)..(1784)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1791)..(1791)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1805)..(1805)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1826)..(1826)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1833)..(1833)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1847)..(1847)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1861)..(1861)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1868)..(1868)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1875)..(1875)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1882)..(1882)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1889)..(1889)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1896)..(1896)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1910)..(1910)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1917)..(1917)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1924)..(1924)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1931)..(1931)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1941)..(1941)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1948)..(1948)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1955)..(1955)
<223>  Xaa can be any naturally occurring amino acid

<400>  60

Met His Gly Gly Gly Pro Pro Ser Gly Asp Ser Ala Cys Pro Leu Arg 
1               5                   10                  15      


Thr Ile Lys Arg Val Gln Phe Gly Val Leu Ser Pro Asp Glu Leu Lys 
            20                  25                  30          


Arg Met Ser Val Thr Glu Gly Gly Ile Lys Tyr Pro Glu Thr Thr Glu 
        35                  40                  45              


Gly Gly Arg Pro Lys Leu Gly Gly Leu Met Asp Pro Arg Gln Gly Val 
    50                  55                  60                  


Ile Glu Arg Thr Gly Arg Cys Gln Thr Cys Ala Gly Asn Met Thr Glu 
65                  70                  75                  80  


Cys Pro Gly His Phe Gly His Ile Glu Leu Ala Lys Pro Val Phe His 
                85                  90                  95      


Val Gly Phe Leu Val Lys Thr Met Lys Val Leu Arg Cys Val Cys Phe 
            100                 105                 110         


Phe Cys Ser Lys Leu Leu Val Asp Ser Asn Asn Pro Lys Ile Lys Asp 
        115                 120                 125             


Ile Leu Ala Lys Ser Lys Gly Gln Pro Lys Lys Arg Leu Thr His Val 
    130                 135                 140                 


Tyr Asp Leu Cys Lys Gly Lys Asn Ile Cys Glu Gly Gly Glu Glu Met 
145                 150                 155                 160 


Asp Asn Lys Phe Gly Val Glu Gln Pro Glu Gly Asp Glu Asp Leu Thr 
                165                 170                 175     


Lys Glu Lys Gly His Gly Gly Cys Gly Arg Tyr Gln Pro Arg Ile Arg 
            180                 185                 190         


Arg Ser Gly Leu Glu Leu Tyr Ala Glu Trp Lys His Val Asn Glu Asp 
        195                 200                 205             


Ser Gln Glu Lys Lys Ile Leu Leu Ser Pro Glu Arg Val His Glu Ile 
    210                 215                 220                 


Phe Lys Arg Ile Ser Asp Glu Glu Cys Phe Val Leu Gly Met Glu Pro 
225                 230                 235                 240 


Arg Tyr Ala Arg Pro Glu Trp Met Ile Val Thr Val Leu Pro Val Pro 
                245                 250                 255     


Pro Leu Ser Val Arg Pro Ala Val Val Met Gln Gly Ser Ala Arg Asn 
            260                 265                 270         


Gln Asp Asp Leu Thr His Lys Leu Ala Asp Ile Val Lys Ile Asn Asn 
        275                 280                 285             


Gln Leu Arg Arg Asn Glu Gln Asn Gly Ala Ala Ala His Val Ile Ala 
    290                 295                 300                 


Glu Asp Val Lys Leu Leu Gln Phe His Val Ala Thr Met Val Asp Asn 
305                 310                 315                 320 


Glu Leu Pro Gly Leu Pro Arg Ala Met Gln Lys Ser Gly Arg Pro Leu 
                325                 330                 335     


Lys Ser Leu Lys Gln Arg Leu Lys Gly Lys Glu Gly Arg Val Arg Gly 
            340                 345                 350         


Asn Leu Met Gly Lys Arg Val Asp Phe Ser Ala Arg Thr Val Ile Thr 
        355                 360                 365             


Pro Asp Pro Asn Leu Ser Ile Asp Gln Val Gly Val Pro Arg Ser Ile 
    370                 375                 380                 


Ala Ala Asn Met Thr Phe Ala Glu Ile Val Thr Pro Phe Asn Ile Asp 
385                 390                 395                 400 


Arg Leu Gln Glu Leu Val Arg Arg Gly Asn Ser Gln Tyr Pro Gly Ala 
                405                 410                 415     


Lys Tyr Ile Ile Arg Asp Asn Gly Asp Arg Ile Asp Leu Arg Phe His 
            420                 425                 430         


Pro Lys Pro Ser Asp Leu His Leu Gln Thr Gly Tyr Lys Val Glu Arg 
        435                 440                 445             


His Met Cys Asp Gly Asp Ile Val Ile Phe Asn Arg Gln Pro Thr Leu 
    450                 455                 460                 


His Lys Met Ser Met Met Gly His Arg Val Arg Ile Leu Pro Trp Ser 
465                 470                 475                 480 


Thr Phe Arg Leu Asn Leu Ser Val Thr Thr Pro Tyr Asn Ala Asp Phe 
                485                 490                 495     


Asp Gly Asp Glu Met Asn Leu His Leu Pro Gln Ser Leu Glu Thr Arg 
            500                 505                 510         


Ala Glu Ile Gln Glu Leu Ala Met Val Pro Arg Met Ile Val Thr Pro 
        515                 520                 525             


Gln Ser Asn Arg Pro Val Met Gly Ile Val Gln Asp Thr Leu Thr Ala 
    530                 535                 540                 


Val Arg Lys Phe Thr Lys Arg Asp Val Phe Leu Glu Arg Gly Glu Val 
545                 550                 555                 560 


Met Asn Leu Leu Met Phe Leu Ser Thr Trp Asp Gly Lys Val Pro Gln 
                565                 570                 575     


Pro Ala Ile Leu Lys Pro Arg Pro Leu Trp Thr Gly Lys Gln Ile Phe 
            580                 585                 590         


Ser Leu Ile Ile Pro Gly His Ile Asn Cys Ile Arg Thr His Ser Thr 
        595                 600                 605             


His Pro Asp Asp Glu Asp Ser Gly Pro Tyr Lys His Ile Ser Pro Gly 
    610                 615                 620                 


Asp Thr Lys Val Val Val Glu Asn Gly Glu Leu Ile Met Gly Ile Leu 
625                 630                 635                 640 


Cys Lys Lys Ser Leu Gly Thr Ser Ala Gly Ser Leu Val His Ile Ser 
                645                 650                 655     


Tyr Leu Glu Met Gly His Asp Ile Thr Arg Leu Phe Tyr Ser Asn Ile 
            660                 665                 670         


Gln Thr Val Ile Asn Asn Trp Leu Leu Ile Glu Gly His Thr Ile Gly 
        675                 680                 685             


Ile Gly Asp Ser Ile Ala Asp Ser Lys Thr Tyr Gln Asp Ile Gln Asn 
    690                 695                 700                 


Thr Ile Lys Lys Ala Lys Gln Asp Val Ile Glu Val Ile Glu Lys Ala 
705                 710                 715                 720 


His Asn Asn Glu Leu Glu Pro Thr Pro Gly Asn Thr Leu Arg Gln Thr 
                725                 730                 735     


Phe Glu Asn Gln Val Asn Arg Ile Leu Asn Asp Ala Arg Asp Lys Thr 
            740                 745                 750         


Gly Ser Ser Ala Gln Lys Ser Leu Ser Glu Tyr Asn Asn Phe Lys Ser 
        755                 760                 765             


Met Val Val Ser Gly Ala Lys Gly Ser Lys Ile Asn Ile Ser Gln Val 
    770                 775                 780                 


Ile Ala Val Val Gly Gln Gln Asn Val Glu Gly Lys Arg Ile Pro Phe 
785                 790                 795                 800 


Gly Phe Lys His Arg Thr Leu Pro His Phe Ile Lys Asp Asp Tyr Gly 
                805                 810                 815     


Pro Glu Ser Arg Gly Phe Val Glu Asn Ser Tyr Leu Ala Gly Leu Thr 
            820                 825                 830         


Pro Thr Glu Phe Phe Phe His Ala Met Gly Gly Arg Glu Gly Leu Ile 
        835                 840                 845             


Asp Thr Ala Val Lys Thr Ala Glu Thr Gly Tyr Ile Gln Arg Arg Leu 
    850                 855                 860                 


Ile Lys Ser Met Glu Ser Val Met Val Lys Tyr Asp Ala Thr Val Arg 
865                 870                 875                 880 


Asn Ser Ile Asn Gln Val Val Gln Leu Arg Tyr Gly Glu Asp Gly Leu 
                885                 890                 895     


Ala Gly Glu Ser Val Glu Phe Gln Asn Leu Ala Thr Leu Lys Pro Ser 
            900                 905                 910         


Asn Lys Ala Phe Glu Lys Lys Phe Arg Phe Asp Tyr Thr Asn Glu Arg 
        915                 920                 925             


Ala Leu Arg Arg Thr Leu Gln Glu Asp Leu Val Lys Asp Val Leu Ser 
    930                 935                 940                 


Asn Ala His Ile Gln Asn Glu Leu Glu Arg Glu Phe Glu Arg Met Arg 
945                 950                 955                 960 


Glu Asp Arg Glu Val Leu Arg Val Ile Phe Pro Thr Gly Asp Ser Lys 
                965                 970                 975     


Val Val Leu Pro Cys Asn Leu Leu Arg Met Ile Trp Asn Ala Gln Lys 
            980                 985                 990         


Ile Phe His Ile Asn Pro Arg Leu  Pro Ser Asp Leu His  Pro Ile Lys 
        995                 1000                 1005             


Val Val  Glu Gly Val Lys Glu  Leu Ser Lys Lys Leu  Val Ile Val 
    1010                 1015                 1020             


Asn Gly  Asp Asp Pro Leu Ser  Arg Gln Ala Gln Glu  Asn Ala Thr 
    1025                 1030                 1035             


Leu Leu  Phe Asn Ile His Leu  Arg Ser Thr Leu Cys  Ser Arg Arg 
    1040                 1045                 1050             


Met Ala  Glu Glu Phe Arg Leu  Ser Gly Glu Ala Phe  Asp Trp Leu 
    1055                 1060                 1065             


Leu Gly  Glu Ile Glu Ser Lys  Phe Asn Gln Ala Ile  Ala His Pro 
    1070                 1075                 1080             


Gly Glu  Met Val Gly Ala Leu  Ala Ala Gln Ser Leu  Gly Glu Pro 
    1085                 1090                 1095             


Ala Thr  Gln Met Thr Leu Asn  Thr Phe His Tyr Ala  Gly Val Ser 
    1100                 1105                 1110             


Ala Lys  Asn Val Thr Leu Gly  Val Pro Arg Leu Lys  Glu Leu Ile 
    1115                 1120                 1125             


Asn Ile  Ser Lys Lys Pro Lys  Thr Pro Ser Leu Thr  Val Phe Leu 
    1130                 1135                 1140             


Leu Gly  Gln Ser Ala Arg Asp  Ala Glu Arg Ala Lys  Asp Ile Leu 
    1145                 1150                 1155             


Cys Arg  Leu Glu His Thr Thr  Leu Arg Lys Val Thr  Ala Asn Thr 
    1160                 1165                 1170             


Ala Ile  Tyr Tyr Asp Pro Asn  Pro Gln Ser Thr Val  Val Ala Glu 
    1175                 1180                 1185             


Asp Gln  Glu Trp Val Asn Val  Tyr Tyr Glu Met Pro  Asp Phe Asp 
    1190                 1195                 1200             


Val Ala  Arg Ile Ser Pro Trp  Leu Leu Arg Val Glu  Leu Asp Arg 
    1205                 1210                 1215             


Lys His  Met Thr Asp Arg Lys  Leu Thr Met Glu Gln  Ile Ala Glu 
    1220                 1225                 1230             


Lys Ile  Asn Ala Gly Phe Gly  Asp Asp Leu Asn Cys  Ile Phe Asn 
    1235                 1240                 1245             


Asp Asp  Asn Ala Glu Lys Leu  Val Leu Arg Ile Arg  Ile Met Asn 
    1250                 1255                 1260             


Ser Asp  Glu Asn Lys Met Gln  Glu Glu Glu Glu Val  Val Asp Lys 
    1265                 1270                 1275             


Met Asp  Asp Asp Val Phe Leu  Arg Cys Ile Glu Ser  Asn Met Leu 
    1280                 1285                 1290             


Thr Asp  Met Thr Leu Gln Gly  Ile Glu Gln Ile Ser  Lys Val Tyr 
    1295                 1300                 1305             


Met His  Leu Pro Gln Thr Asp  Asn Lys Lys Lys Ile  Ile Ile Thr 
    1310                 1315                 1320             


Glu Asp  Gly Glu Phe Lys Ala  Leu Gln Glu Trp Ile  Leu Glu Thr 
    1325                 1330                 1335             


Asp Gly  Val Ser Leu Met Arg  Val Leu Ser Glu Lys  Asp Val Asp 
    1340                 1345                 1350             


Pro Val  Arg Thr Thr Ser Asn  Asp Ile Val Glu Ile  Phe Thr Val 
    1355                 1360                 1365             


Leu Gly  Ile Glu Ala Val Arg  Lys Ala Leu Glu Arg  Glu Leu Tyr 
    1370                 1375                 1380             


His Val  Ile Ser Phe Asp Gly  Ser Tyr Val Asn Tyr  Arg His Leu 
    1385                 1390                 1395             


Ala Leu  Leu Cys Asp Thr Met  Thr Cys Arg Gly His  Leu Met Ala 
    1400                 1405                 1410             


Ile Thr  Arg His Gly Val Asn  Arg Gln Asp Thr Gly  Pro Leu Met 
    1415                 1420                 1425             


Lys Cys  Ser Phe Glu Glu Thr  Val Asp Val Leu Met  Glu Ala Ala 
    1430                 1435                 1440             


Ala His  Gly Glu Ser Asp Pro  Met Lys Gly Val Ser  Glu Asn Ile 
    1445                 1450                 1455             


Met Leu  Gly Gln Leu Ala Pro  Ala Gly Thr Gly Cys  Phe Asp Leu 
    1460                 1465                 1470             


Leu Leu  Asp Ala Glu Lys Cys  Lys Tyr Gly Met Glu  Ile Pro Thr 
    1475                 1480                 1485             


Asn Ile  Pro Gly Leu Gly Ala  Ala Gly Pro Thr Gly  Met Phe Phe 
    1490                 1495                 1500             


Gly Ser  Ala Pro Ser Pro Met  Gly Gly Ile Ser Pro  Ala Met Thr 
    1505                 1510                 1515             


Pro Trp  Asn Gln Gly Ala Thr  Pro Ala Tyr Gly Ala  Trp Ser Pro 
    1520                 1525                 1530             


Ser Val  Gly Ser Gly Met Thr  Pro Gly Ala Ala Gly  Phe Ser Pro 
    1535                 1540                 1545             


Ser Ala  Ala Ser Asp Ala Ser  Gly Phe Ser Pro Gly  Tyr Xaa Pro 
    1550                 1555                 1560             


Ala Trp  Ser Pro Thr Pro Gly  Ser Pro Gly Ser Pro  Gly Pro Ser 
    1565                 1570                 1575             


Ser Pro  Tyr Ile Pro Ser Pro  Gly Gly Ala Met Ser  Pro Ser Tyr 
    1580                 1585                 1590             


Xaa Pro  Thr Ser Pro Ala Tyr  Glu Pro Arg Ser Pro  Gly Gly Tyr 
    1595                 1600                 1605             


Thr Pro  Gln Ser Pro Ser Tyr  Xaa Pro Thr Ser Pro  Ser Tyr Xaa 
    1610                 1615                 1620             


Pro Thr  Ser Pro Ser Tyr Xaa  Pro Thr Ser Pro Asn  Tyr Xaa Pro 
    1625                 1630                 1635             


Thr Ser  Pro Ser Tyr Xaa Pro  Thr Ser Pro Ser Tyr  Xaa Pro Thr 
    1640                 1645                 1650             


Ser Pro  Ser Tyr Xaa Pro Thr  Ser Pro Ser Tyr Xaa  Pro Thr Ser 
    1655                 1660                 1665             


Pro Ser  Tyr Xaa Pro Thr Ser  Pro Ser Tyr Ser Pro  Thr Ser Pro 
    1670                 1675                 1680             


Ser Tyr  Xaa Pro Thr Ser Pro  Ser Tyr Xaa Pro Thr  Ser Pro Ser 
    1685                 1690                 1695             


Tyr Xaa  Pro Thr Ser Pro Ser  Tyr Xaa Pro Thr Ser  Pro Ser Tyr 
    1700                 1705                 1710             


Xaa Pro  Thr Ser Pro Ser Tyr  Xaa Pro Thr Ser Pro  Ser Tyr Xaa 
    1715                 1720                 1725             


Pro Thr  Ser Pro Ser Tyr Xaa  Pro Thr Ser Pro Ser  Tyr Xaa Pro 
    1730                 1735                 1740             


Thr Ser  Pro Asn Tyr Xaa Pro  Thr Ser Pro Asn Tyr  Thr Pro Thr 
    1745                 1750                 1755             


Ser Pro  Ser Tyr Xaa Pro Thr  Ser Pro Ser Tyr Xaa  Pro Thr Ser 
    1760                 1765                 1770             


Pro Asn  Tyr Thr Pro Thr Ser  Pro Asn Tyr Xaa Pro  Thr Ser Pro 
    1775                 1780                 1785             


Ser Tyr  Xaa Pro Thr Ser Pro  Ser Tyr Ser Pro Thr  Ser Pro Ser 
    1790                 1795                 1800             


Tyr Xaa  Pro Ser Ser Pro Arg  Tyr Thr Pro Gln Ser  Pro Thr Tyr 
    1805                 1810                 1815             


Thr Pro  Ser Ser Pro Ser Tyr  Xaa Pro Ser Ser Pro  Ser Tyr Xaa 
    1820                 1825                 1830             


Pro Thr  Ser Pro Lys Tyr Thr  Pro Thr Ser Pro Ser  Tyr Xaa Pro 
    1835                 1840                 1845             


Ser Ser  Pro Glu Tyr Thr Pro  Thr Ser Pro Lys Tyr  Xaa Pro Thr 
    1850                 1855                 1860             


Ser Pro  Lys Tyr Xaa Pro Thr  Ser Pro Lys Tyr Xaa  Pro Thr Ser 
    1865                 1870                 1875             


Pro Thr  Tyr Xaa Pro Thr Thr  Pro Lys Tyr Xaa Pro  Thr Ser Pro 
    1880                 1885                 1890             


Thr Tyr  Xaa Pro Thr Ser Pro  Val Tyr Thr Pro Thr  Ser Pro Lys 
    1895                 1900                 1905             


Tyr Xaa  Pro Thr Ser Pro Thr  Tyr Xaa Pro Thr Ser  Pro Lys Tyr 
    1910                 1915                 1920             


Xaa Pro  Thr Ser Pro Thr Tyr  Xaa Pro Thr Ser Pro  Lys Gly Ser 
    1925                 1930                 1935             


Thr Tyr  Xaa Pro Thr Ser Pro  Gly Tyr Xaa Pro Thr  Ser Pro Thr 
    1940                 1945                 1950             


Tyr Xaa  Leu Thr Ser Pro Ala  Ile Ser Pro Asp Asp  Ser Asp Glu 
    1955                 1960                 1965             


Glu Asn  
    1970 


<210>  61
<211>  317
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<400>  61

Met Ser Cys Thr Arg Met Ile Gln Val Leu Asp Pro Arg Pro Leu Thr 
1               5                   10                  15      


Ser Ser Val Met Pro Val Asp Val Ala Met Arg Leu Cys Leu Ala His 
            20                  25                  30          


Ser Pro Pro Val Lys Ser Phe Leu Gly Pro Tyr Asp Glu Phe Gln Arg 
        35                  40                  45              


Arg His Phe Val Asn Lys Leu Lys Pro Leu Lys Ser Cys Leu Asn Ile 
    50                  55                  60                  


Lys His Lys Ala Lys Ser Gln Asn Asp Trp Lys Cys Ser His Asn Gln 
65                  70                  75                  80  


Ala Lys Lys Arg Val Val Phe Ala Asp Xaa Lys Gly Leu Xaa Leu Xaa 
                85                  90                  95      


Ala Ile His Val Phe Xaa Asp Leu Pro Glu Glu Pro Ala Trp Asp Leu 
            100                 105                 110         


Gln Phe Asp Leu Leu Asp Leu Asn Asp Ile Ser Ser Ala Leu Lys His 
        115                 120                 125             


His Glu Glu Lys Asn Leu Ile Leu Asp Phe Pro Gln Pro Ser Thr Asp 
    130                 135                 140                 


Tyr Leu Ser Phe Arg Ser His Phe Gln Lys Asn Phe Val Cys Leu Glu 
145                 150                 155                 160 


Asn Cys Ser Leu Gln Glu Arg Thr Val Thr Gly Thr Val Lys Val Lys 
                165                 170                 175     


Asn Val Ser Phe Glu Lys Lys Val Gln Ile Arg Ile Thr Phe Asp Ser 
            180                 185                 190         


Trp Lys Asn Tyr Thr Asp Val Asp Cys Val Tyr Met Lys Asn Val Tyr 
        195                 200                 205             


Gly Gly Thr Asp Ser Asp Thr Phe Ser Phe Ala Ile Asp Leu Pro Pro 
    210                 215                 220                 


Val Ile Pro Thr Glu Gln Lys Ile Glu Phe Cys Ile Ser Tyr His Ala 
225                 230                 235                 240 


Asn Gly Gln Val Phe Trp Asp Asn Asn Asp Gly Gln Asn Tyr Arg Ile 
                245                 250                 255     


Val His Val Gln Trp Lys Pro Asp Gly Val Gln Thr Gln Met Ala Pro 
            260                 265                 270         


Gln Asp Cys Ala Phe His Gln Thr Ser Pro Lys Thr Glu Leu Glu Ser 
        275                 280                 285             


Thr Ile Phe Gly Ser Pro Arg Leu Ala Ser Gly Leu Phe Pro Glu Trp 
    290                 295                 300                 


Gln Ser Trp Gly Arg Met Glu Asn Leu Ala Ser Tyr Arg 
305                 310                 315         


<210>  62
<211>  928
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (249)..(249)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (252)..(252)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (373)..(373)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (807)..(807)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (811)..(811)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (821)..(821)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (826)..(826)
<223>  Xaa can be any naturally occurring amino acid

<400>  62

Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 
1               5                   10                  15      


Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 
            20                  25                  30          


Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 
        35                  40                  45              


Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 
    50                  55                  60                  


Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 
65                  70                  75                  80  


Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 
                85                  90                  95      


Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 
            100                 105                 110         


Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 
        115                 120                 125             


His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 
    130                 135                 140                 


Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 
145                 150                 155                 160 


Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 
                165                 170                 175     


Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 
            180                 185                 190         


Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 
        195                 200                 205             


Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 
    210                 215                 220                 


Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 
225                 230                 235                 240 


Thr Ala Val Ile Pro Ile Asn Gly Xaa Pro Arg Xaa Pro Arg Arg Gly 
                245                 250                 255     


Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 
            260                 265                 270         


Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 
        275                 280                 285             


Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 
    290                 295                 300                 


Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 
305                 310                 315                 320 


Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 
                325                 330                 335     


Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 
            340                 345                 350         


Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 
        355                 360                 365             


Ile Pro Pro His Xaa Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 
    370                 375                 380                 


Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 
385                 390                 395                 400 


Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 
                405                 410                 415     


Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 
            420                 425                 430         


Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 
        435                 440                 445             


Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 
    450                 455                 460                 


Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 
465                 470                 475                 480 


Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 
                485                 490                 495     


Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 
            500                 505                 510         


Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 
        515                 520                 525             


Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 
    530                 535                 540                 


Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 
545                 550                 555                 560 


Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 
                565                 570                 575     


Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 
            580                 585                 590         


Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 
        595                 600                 605             


Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 
    610                 615                 620                 


Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 
625                 630                 635                 640 


Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 
                645                 650                 655     


Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 
            660                 665                 670         


His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 
        675                 680                 685             


Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 
    690                 695                 700                 


Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 
705                 710                 715                 720 


Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 
                725                 730                 735     


Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 
            740                 745                 750         


Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 
        755                 760                 765             


Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 
    770                 775                 780                 


Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 
785                 790                 795                 800 


Gly Gly Asn Ile Tyr Ile Xaa Pro Leu Lys Xaa Pro Tyr Lys Ile Ser 
                805                 810                 815     


Glu Gly Leu Pro Xaa Pro Thr Lys Met Xaa Pro Arg Ser Arg Ile Leu 
            820                 825                 830         


Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 
        835                 840                 845             


Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 
    850                 855                 860                 


Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 
865                 870                 875                 880 


Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 
                885                 890                 895     


Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 
            900                 905                 910         


Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 
        915                 920                 925             


<210>  63
<211>  1400
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (1394)..(1394)
<223>  Xaa can be any naturally occurring amino acid

<400>  63

Met Glu Leu Leu Pro Pro Leu Pro Gln Ser Phe Leu Leu Leu Leu Leu 
1               5                   10                  15      


Leu Pro Ala Lys Pro Ala Ala Gly Glu Asp Trp Gln Cys Pro Arg Thr 
            20                  25                  30          


Pro Tyr Ala Ala Ser Arg Asp Phe Asp Val Lys Tyr Val Val Pro Ser 
        35                  40                  45              


Phe Ser Ala Gly Gly Leu Val Gln Ala Met Val Thr Tyr Glu Gly Asp 
    50                  55                  60                  


Arg Asn Glu Ser Ala Val Phe Val Ala Ile Arg Asn Arg Leu His Val 
65                  70                  75                  80  


Leu Gly Pro Asp Leu Lys Ser Val Gln Ser Leu Ala Thr Gly Pro Ala 
                85                  90                  95      


Gly Asp Pro Gly Cys Gln Thr Cys Ala Ala Cys Gly Pro Gly Pro His 
            100                 105                 110         


Gly Pro Pro Gly Asp Thr Asp Thr Lys Val Leu Val Leu Asp Pro Ala 
        115                 120                 125             


Leu Pro Ala Leu Val Ser Cys Gly Ser Ser Leu Gln Gly Arg Cys Phe 
    130                 135                 140                 


Leu His Asp Leu Glu Pro Gln Gly Thr Ala Val His Leu Ala Ala Pro 
145                 150                 155                 160 


Ala Cys Leu Phe Ser Ala His His Asn Arg Pro Asp Asp Cys Pro Asp 
                165                 170                 175     


Cys Val Ala Ser Pro Leu Gly Thr Arg Val Thr Val Val Glu Gln Gly 
            180                 185                 190         


Gln Ala Ser Tyr Phe Tyr Val Ala Ser Ser Leu Asp Ala Ala Val Ala 
        195                 200                 205             


Gly Ser Phe Ser Pro Arg Ser Val Ser Ile Arg Arg Leu Lys Ala Asp 
    210                 215                 220                 


Ala Ser Gly Phe Ala Pro Gly Phe Val Ala Leu Ser Val Leu Pro Lys 
225                 230                 235                 240 


His Leu Val Ser Tyr Ser Ile Glu Tyr Val His Ser Phe His Thr Gly 
                245                 250                 255     


Ala Phe Val Tyr Phe Leu Thr Val Gln Pro Ala Ser Val Thr Asp Asp 
            260                 265                 270         


Pro Ser Ala Leu His Thr Arg Leu Ala Arg Leu Ser Ala Thr Glu Pro 
        275                 280                 285             


Glu Leu Gly Asp Tyr Arg Glu Leu Val Leu Asp Cys Arg Phe Ala Pro 
    290                 295                 300                 


Lys Arg Arg Arg Arg Gly Ala Pro Glu Gly Gly Gln Pro Tyr Pro Val 
305                 310                 315                 320 


Leu Gln Val Ala His Ser Ala Pro Val Gly Ala Gln Leu Ala Thr Glu 
                325                 330                 335     


Leu Ser Ile Ala Glu Gly Gln Glu Val Leu Phe Gly Val Phe Val Thr 
            340                 345                 350         


Gly Lys Asp Gly Gly Pro Gly Val Gly Pro Asn Ser Val Val Cys Ala 
        355                 360                 365             


Phe Pro Ile Asp Leu Leu Asp Thr Leu Ile Asp Glu Gly Val Glu Arg 
    370                 375                 380                 


Cys Cys Glu Ser Pro Val His Pro Gly Leu Arg Arg Gly Leu Asp Phe 
385                 390                 395                 400 


Phe Gln Ser Pro Ser Phe Cys Pro Asn Pro Pro Gly Leu Glu Ala Leu 
                405                 410                 415     


Ser Pro Asn Thr Ser Cys Arg His Phe Pro Leu Leu Val Ser Ser Ser 
            420                 425                 430         


Phe Ser Arg Val Asp Leu Phe Asn Gly Leu Leu Gly Pro Val Gln Val 
        435                 440                 445             


Thr Ala Leu Tyr Val Thr Arg Leu Asp Asn Val Thr Val Ala His Met 
    450                 455                 460                 


Gly Thr Met Asp Gly Arg Ile Leu Gln Val Glu Leu Val Arg Ser Leu 
465                 470                 475                 480 


Asn Tyr Leu Leu Tyr Val Ser Asn Phe Ser Leu Gly Asp Ser Gly Gln 
                485                 490                 495     


Pro Val Gln Arg Asp Val Ser Arg Leu Gly Asp His Leu Leu Phe Ala 
            500                 505                 510         


Ser Gly Asp Gln Val Phe Gln Val Pro Ile Arg Gly Pro Gly Cys Arg 
        515                 520                 525             


His Phe Leu Thr Cys Gly Arg Cys Leu Arg Ala Trp His Phe Met Gly 
    530                 535                 540                 


Cys Gly Trp Cys Gly Asn Met Cys Gly Gln Gln Lys Glu Cys Pro Gly 
545                 550                 555                 560 


Ser Trp Gln Gln Asp His Cys Pro Pro Lys Leu Thr Glu Phe His Pro 
                565                 570                 575     


His Ser Gly Pro Leu Arg Gly Ser Thr Arg Leu Thr Leu Cys Gly Ser 
            580                 585                 590         


Asn Phe Tyr Leu His Pro Ser Gly Leu Val Pro Glu Gly Thr His Gln 
        595                 600                 605             


Val Thr Val Gly Gln Ser Pro Cys Arg Pro Leu Pro Lys Asp Ser Ser 
    610                 615                 620                 


Lys Leu Arg Pro Val Pro Arg Lys Asp Phe Val Glu Glu Phe Glu Cys 
625                 630                 635                 640 


Glu Leu Glu Pro Leu Gly Thr Gln Ala Val Gly Pro Thr Asn Val Ser 
                645                 650                 655     


Leu Thr Val Thr Asn Met Pro Pro Gly Lys His Phe Arg Val Asp Gly 
            660                 665                 670         


Thr Ser Val Leu Arg Gly Phe Ser Phe Met Glu Pro Val Leu Ile Ala 
        675                 680                 685             


Val Gln Pro Leu Phe Gly Pro Arg Ala Gly Gly Thr Cys Leu Thr Leu 
    690                 695                 700                 


Glu Gly Gln Ser Leu Ser Val Gly Thr Ser Arg Ala Val Leu Val Asn 
705                 710                 715                 720 


Gly Thr Glu Cys Leu Leu Ala Arg Val Ser Glu Gly Gln Leu Leu Cys 
                725                 730                 735     


Ala Thr Pro Pro Gly Ala Thr Val Ala Ser Val Pro Leu Ser Leu Gln 
            740                 745                 750         


Val Gly Gly Ala Gln Val Pro Gly Ser Trp Thr Phe Gln Tyr Arg Glu 
        755                 760                 765             


Asp Pro Val Val Leu Ser Ile Ser Pro Asn Cys Gly Tyr Ile Asn Ser 
    770                 775                 780                 


His Ile Thr Ile Cys Gly Gln His Leu Thr Ser Ala Trp His Leu Val 
785                 790                 795                 800 


Leu Ser Phe His Asp Gly Leu Arg Ala Val Glu Ser Arg Cys Glu Arg 
                805                 810                 815     


Gln Leu Pro Glu Gln Gln Leu Cys Arg Leu Pro Glu Tyr Val Val Arg 
            820                 825                 830         


Asp Pro Gln Gly Trp Val Ala Gly Asn Leu Ser Ala Arg Gly Asp Gly 
        835                 840                 845             


Ala Ala Gly Phe Thr Leu Pro Gly Phe Arg Phe Leu Pro Pro Pro His 
    850                 855                 860                 


Pro Pro Ser Ala Asn Leu Val Pro Leu Lys Pro Glu Glu His Ala Ile 
865                 870                 875                 880 


Lys Phe Glu Tyr Ile Gly Leu Gly Ala Val Ala Asp Cys Val Gly Ile 
                885                 890                 895     


Asn Val Thr Val Gly Gly Glu Ser Cys Gln His Glu Phe Arg Gly Asp 
            900                 905                 910         


Met Val Val Cys Pro Leu Pro Pro Ser Leu Gln Leu Gly Gln Asp Gly 
        915                 920                 925             


Ala Pro Leu Gln Val Cys Val Asp Gly Glu Cys His Ile Leu Gly Arg 
    930                 935                 940                 


Val Val Arg Pro Gly Pro Asp Gly Val Pro Gln Ser Thr Leu Leu Gly 
945                 950                 955                 960 


Ile Leu Leu Pro Leu Leu Leu Leu Val Ala Ala Leu Ala Thr Ala Leu 
                965                 970                 975     


Val Phe Ser Tyr Trp Trp Arg Arg Lys Gln Leu Val Leu Pro Pro Asn 
            980                 985                 990         


Leu Asn Asp Leu Ala Ser Leu Asp  Gln Thr Ala Gly Ala  Thr Pro Leu 
        995                 1000                 1005             


Pro Ile  Leu Tyr Ser Gly Ser  Asp Tyr Arg Ser Gly  Leu Ala Leu 
    1010                 1015                 1020             


Pro Ala  Ile Asp Gly Leu Asp  Ser Thr Thr Cys Val  His Gly Ala 
    1025                 1030                 1035             


Ser Phe  Ser Asp Ser Glu Asp  Glu Ser Cys Val Pro  Leu Leu Arg 
    1040                 1045                 1050             


Lys Glu  Ser Ile Gln Leu Arg  Asp Leu Asp Ser Ala  Leu Leu Ala 
    1055                 1060                 1065             


Glu Val  Lys Asp Val Leu Ile  Pro His Glu Arg Val  Val Thr His 
    1070                 1075                 1080             


Ser Asp  Arg Val Ile Gly Lys  Gly His Phe Gly Val  Val Tyr His 
    1085                 1090                 1095             


Gly Glu  Tyr Ile Asp Gln Ala  Gln Asn Arg Ile Gln  Cys Ala Ile 
    1100                 1105                 1110             


Lys Ser  Leu Ser Arg Ile Thr  Glu Met Gln Gln Val  Glu Ala Phe 
    1115                 1120                 1125             


Leu Arg  Glu Gly Leu Leu Met  Arg Gly Leu Asn His  Pro Asn Val 
    1130                 1135                 1140             


Leu Ala  Leu Ile Gly Ile Met  Leu Pro Pro Glu Gly  Leu Pro His 
    1145                 1150                 1155             


Val Leu  Leu Pro Tyr Met Cys  His Gly Asp Leu Leu  Gln Phe Ile 
    1160                 1165                 1170             


Arg Ser  Pro Gln Arg Asn Pro  Thr Val Lys Asp Leu  Ile Ser Phe 
    1175                 1180                 1185             


Gly Leu  Gln Val Ala Arg Gly  Met Glu Tyr Leu Ala  Glu Gln Lys 
    1190                 1195                 1200             


Phe Val  His Arg Asp Leu Ala  Ala Arg Asn Cys Met  Leu Asp Glu 
    1205                 1210                 1215             


Ser Phe  Thr Val Lys Val Ala  Asp Phe Gly Leu Ala  Arg Asp Ile 
    1220                 1225                 1230             


Leu Asp  Arg Glu Tyr Tyr Ser  Val Gln Gln His Arg  His Ala Arg 
    1235                 1240                 1245             


Leu Pro  Val Lys Trp Met Ala  Leu Glu Ser Leu Gln  Thr Tyr Arg 
    1250                 1255                 1260             


Phe Thr  Thr Lys Ser Asp Val  Trp Ser Phe Gly Val  Leu Leu Trp 
    1265                 1270                 1275             


Glu Leu  Leu Thr Arg Gly Ala  Pro Pro Tyr Arg His  Ile Asp Pro 
    1280                 1285                 1290             


Phe Asp  Leu Thr His Phe Leu  Ala Gln Gly Arg Arg  Leu Pro Gln 
    1295                 1300                 1305             


Pro Glu  Tyr Cys Pro Asp Ser  Leu Tyr Gln Val Met  Gln Gln Cys 
    1310                 1315                 1320             


Trp Glu  Ala Asp Pro Ala Val  Arg Pro Thr Phe Arg  Val Leu Val 
    1325                 1330                 1335             


Gly Glu  Val Glu Gln Ile Val  Ser Ala Leu Leu Gly  Asp His Tyr 
    1340                 1345                 1350             


Val Gln  Leu Pro Ala Thr Tyr  Met Asn Leu Gly Pro  Ser Thr Ser 
    1355                 1360                 1365             


His Glu  Met Asn Val Arg Pro  Glu Gln Pro Gln Phe  Ser Pro Met 
    1370                 1375                 1380             


Pro Gly  Asn Val Arg Arg Pro  Arg Pro Leu Xaa Glu  Pro Pro Arg 
    1385                 1390                 1395             


Pro Thr  
    1400 


<210>  64
<211>  473
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (191)..(191)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid

<400>  64

Met Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Xaa 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Xaa Pro Lys Cys Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp Leu Asp Glu Thr 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Xaa Pro Ala Gln Leu Leu Cys 
        115                 120                 125             


Ser Xaa Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met 
    130                 135                 140                 


Cys Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 
145                 150                 155                 160 


Ser Glu Met Lys Tyr Leu Gly Xaa Pro Ile Thr Thr Val Pro Lys Leu 
                165                 170                 175     


Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Xaa Asp 
            180                 185                 190         


Glu Leu Met Glu Phe Xaa Leu Lys Asp Gln Glu Ala Lys Val Ser Arg 
        195                 200                 205             


Ser Gly Leu Tyr Arg Xaa Pro Xaa Met Pro Glu Asn Leu Asn Arg Pro 
    210                 215                 220                 


Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Thr Ile Pro Asp Lys 
225                 230                 235                 240 


Val Lys Lys Lys Tyr Phe Ser Gly Gln Gly Lys Leu Arg Lys Gly Leu 
                245                 250                 255     


Cys Leu Lys Lys Thr Val Ser Leu Cys Asp Ile Thr Ile Thr Gln Met 
            260                 265                 270         


Leu Glu Glu Asp Ser Asn Gln Gly His Leu Ile Gly Asp Phe Ser Lys 
        275                 280                 285             


Val Cys Ala Leu Pro Thr Val Ser Gly Lys His Gln Asp Leu Lys Tyr 
    290                 295                 300                 


Val Asn Pro Glu Thr Val Ala Ala Leu Leu Ser Gly Lys Phe Gln Gly 
305                 310                 315                 320 


Leu Ile Glu Lys Phe Tyr Val Ile Asp Cys Arg Tyr Pro Tyr Glu Tyr 
                325                 330                 335     


Leu Gly Gly His Ile Gln Gly Ala Leu Asn Leu Tyr Ser Gln Glu Glu 
            340                 345                 350         


Leu Phe Asn Phe Phe Leu Lys Lys Pro Ile Val Pro Leu Asp Thr Gln 
        355                 360                 365             


Lys Arg Ile Ile Ile Val Phe His Cys Glu Phe Ser Ser Glu Arg Gly 
    370                 375                 380                 


Pro Arg Met Cys Arg Cys Leu Arg Glu Glu Asp Arg Ser Leu Asn Gln 
385                 390                 395                 400 


Tyr Pro Ala Leu Tyr Tyr Pro Glu Leu Tyr Ile Leu Lys Gly Gly Tyr 
                405                 410                 415     


Arg Asp Phe Phe Pro Glu Tyr Met Glu Leu Cys Glu Pro Gln Ser Tyr 
            420                 425                 430         


Cys Pro Met His His Gln Asp His Lys Thr Glu Leu Leu Arg Cys Arg 
        435                 440                 445             


Ser Gln Ser Lys Val Gln Glu Gly Glu Arg Gln Leu Arg Glu Gln Ile 
    450                 455                 460                 


Ala Leu Leu Val Lys Asp Met Ser Pro 
465                 470             


<210>  65
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  65

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  66
<211>  858
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (57)..(57)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<400>  66

Met Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys 
1               5                   10                  15      


Ala Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys 
            20                  25                  30          


Ser Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser 
        35                  40                  45              


Ala Arg Ala Gly Glu Xaa Arg Phe Xaa Asp Xaa Arg Lys Asp Glu Gln 
    50                  55                  60                  


Glu Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu 
65                  70                  75                  80  


Leu Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp Gly Ala 
                85                  90                  95      


Gly Phe Leu Ile Asn Leu Ile Asp Ser Pro Gly His Val Asp Phe Ser 
            100                 105                 110         


Ser Glu Val Thr Ala Ala Leu Arg Val Thr Asp Gly Ala Leu Val Val 
        115                 120                 125             


Val Asp Cys Val Ser Gly Val Cys Val Gln Thr Glu Thr Val Leu Arg 
    130                 135                 140                 


Gln Ala Ile Ala Glu Arg Ile Lys Pro Val Leu Met Met Asn Lys Met 
145                 150                 155                 160 


Asp Arg Ala Leu Leu Glu Leu Gln Leu Glu Pro Glu Glu Leu Tyr Gln 
                165                 170                 175     


Thr Phe Gln Arg Ile Val Glu Asn Val Asn Val Ile Ile Ser Thr Tyr 
            180                 185                 190         


Gly Glu Gly Glu Ser Gly Pro Met Gly Asn Ile Met Ile Asp Pro Val 
        195                 200                 205             


Leu Gly Thr Val Gly Phe Gly Ser Gly Leu His Gly Trp Ala Phe Thr 
    210                 215                 220                 


Leu Lys Gln Phe Ala Glu Met Tyr Val Ala Lys Phe Ala Ala Lys Gly 
225                 230                 235                 240 


Glu Gly Gln Leu Gly Pro Ala Glu Arg Ala Lys Lys Val Glu Asp Met 
                245                 250                 255     


Met Lys Lys Leu Trp Gly Asp Arg Tyr Phe Asp Pro Ala Asn Gly Lys 
            260                 265                 270         


Phe Ser Lys Ser Ala Thr Ser Pro Glu Gly Lys Lys Leu Pro Arg Thr 
        275                 280                 285             


Phe Cys Gln Leu Ile Leu Asp Pro Ile Phe Lys Val Phe Asp Ala Ile 
    290                 295                 300                 


Met Asn Phe Lys Lys Glu Glu Thr Ala Lys Leu Ile Glu Lys Leu Asp 
305                 310                 315                 320 


Ile Lys Leu Asp Ser Glu Asp Lys Asp Lys Glu Gly Lys Pro Leu Leu 
                325                 330                 335     


Lys Ala Val Met Arg Arg Trp Leu Pro Ala Gly Asp Ala Leu Leu Gln 
            340                 345                 350         


Met Ile Thr Ile His Leu Pro Ser Pro Val Thr Ala Gln Lys Tyr Arg 
        355                 360                 365             


Cys Glu Leu Leu Tyr Glu Gly Pro Pro Asp Asp Glu Ala Ala Met Gly 
    370                 375                 380                 


Ile Lys Ser Cys Asp Pro Lys Gly Pro Leu Met Met Tyr Ile Ser Lys 
385                 390                 395                 400 


Met Val Pro Thr Ser Asp Lys Gly Arg Phe Tyr Ala Phe Gly Arg Val 
                405                 410                 415     


Phe Ser Gly Leu Val Ser Thr Gly Leu Lys Val Arg Ile Met Gly Pro 
            420                 425                 430         


Asn Tyr Thr Pro Gly Lys Lys Glu Asp Leu Tyr Leu Lys Pro Ile Gln 
        435                 440                 445             


Arg Thr Ile Leu Met Met Gly Arg Tyr Val Glu Pro Ile Glu Asp Val 
    450                 455                 460                 


Pro Cys Gly Asn Ile Val Gly Leu Val Gly Val Asp Gln Phe Leu Val 
465                 470                 475                 480 


Lys Thr Gly Thr Ile Thr Thr Phe Glu His Ala His Asn Met Arg Val 
                485                 490                 495     


Met Lys Phe Ser Val Ser Pro Val Val Arg Val Ala Val Glu Ala Lys 
            500                 505                 510         


Asn Pro Ala Asp Leu Pro Lys Leu Val Glu Gly Leu Lys Arg Leu Ala 
        515                 520                 525             


Lys Ser Asp Pro Met Val Gln Cys Ile Ile Glu Glu Ser Gly Glu His 
    530                 535                 540                 


Ile Ile Ala Gly Ala Gly Glu Leu His Leu Glu Ile Cys Leu Lys Asp 
545                 550                 555                 560 


Leu Glu Glu Asp His Ala Cys Ile Pro Ile Lys Lys Ser Asp Pro Val 
                565                 570                 575     


Val Ser Tyr Arg Glu Thr Val Ser Glu Glu Ser Asn Val Leu Cys Leu 
            580                 585                 590         


Ser Lys Ser Pro Asn Lys His Asn Arg Leu Tyr Met Lys Ala Arg Pro 
        595                 600                 605             


Phe Pro Asp Gly Leu Ala Glu Asp Ile Asp Lys Gly Glu Val Ser Ala 
    610                 615                 620                 


Arg Gln Glu Leu Lys Gln Arg Ala Arg Tyr Leu Ala Glu Lys Tyr Glu 
625                 630                 635                 640 


Trp Asp Val Ala Glu Ala Arg Lys Ile Trp Cys Phe Gly Pro Asp Gly 
                645                 650                 655     


Thr Gly Pro Asn Ile Leu Thr Asp Ile Thr Lys Gly Val Gln Tyr Leu 
            660                 665                 670         


Asn Glu Ile Lys Asp Ser Val Val Ala Gly Phe Gln Trp Ala Thr Lys 
        675                 680                 685             


Glu Gly Ala Leu Cys Glu Glu Asn Met Arg Gly Val Arg Phe Asp Val 
    690                 695                 700                 


His Asp Val Thr Leu His Ala Asp Ala Ile His Arg Gly Gly Gly Gln 
705                 710                 715                 720 


Ile Ile Pro Thr Ala Arg Arg Cys Leu Tyr Ala Ser Val Leu Thr Ala 
                725                 730                 735     


Gln Pro Arg Leu Met Glu Pro Ile Tyr Leu Val Glu Ile Gln Cys Pro 
            740                 745                 750         


Glu Gln Val Val Gly Gly Ile Tyr Gly Val Leu Asn Arg Lys Arg Gly 
        755                 760                 765             


His Val Phe Glu Glu Ser Gln Val Ala Gly Thr Pro Met Phe Val Val 
    770                 775                 780                 


Lys Ala Tyr Leu Pro Val Asn Glu Ser Phe Gly Phe Thr Ala Asp Leu 
785                 790                 795                 800 


Arg Ser Asn Thr Gly Gly Gln Ala Phe Pro Gln Cys Val Phe Asp His 
                805                 810                 815     


Trp Gln Ile Leu Pro Gly Asp Pro Phe Asp Asn Ser Ser Arg Pro Ser 
            820                 825                 830         


Gln Val Val Ala Glu Thr Arg Lys Arg Lys Gly Leu Lys Glu Gly Ile 
        835                 840                 845             


Pro Ala Leu Asp Asn Phe Leu Asp Lys Leu 
    850                 855             


<210>  67
<211>  93
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (53)..(53)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (56)..(56)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<400>  67

Val Asn Phe Thr Val Asp Gln Ile Arg Ala Ile Met Asp Lys Lys Ala 
1               5                   10                  15      


Asn Ile Arg Asn Met Ser Val Ile Ala His Val Asp His Gly Lys Ser 
            20                  25                  30          


Thr Leu Thr Asp Ser Leu Val Cys Lys Ala Gly Ile Ile Ala Ser Ala 
        35                  40                  45              


Arg Ala Gly Glu Xaa Arg Phe Xaa Asp Xaa Arg Lys Asp Glu Gln Glu 
    50                  55                  60                  


Arg Cys Ile Thr Ile Lys Ser Thr Ala Ile Ser Leu Phe Tyr Glu Leu 
65                  70                  75                  80  


Ser Glu Asn Asp Leu Asn Phe Ile Lys Gln Ser Lys Asp 
                85                  90              


<210>  68
<211>  15
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa can be any naturally occurring amino acid

<400>  68

Arg Arg Thr Xaa Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu 
1               5                   10                  15  


<210>  69
<211>  59
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (14)..(14)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<400>  69

Glu Glu Pro Gln Ser Asp Pro Xaa Val Glu Pro Pro Leu Xaa Gln Glu 
1               5                   10                  15      


Xaa Phe Xaa Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu Xaa 
            20                  25                  30          


Pro Leu Pro Xaa Gln Ala Met Asp Asp Leu Met Leu Xaa Pro Asp Asp 
        35                  40                  45              


Ile Glu Gln Trp Phe Xaa Glu Asp Pro Gly Pro 
    50                  55                  


<210>  70
<211>  60
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (55)..(55)
<223>  Xaa can be any naturally occurring amino acid

<400>  70

Met Glu Glu Pro Gln Ser Asp Pro Xaa Val Glu Pro Pro Leu Xaa Gln 
1               5                   10                  15      


Glu Xaa Phe Xaa Asp Leu Trp Lys Leu Leu Pro Glu Asn Asn Val Leu 
            20                  25                  30          


Xaa Pro Leu Pro Xaa Gln Ala Met Asp Asp Leu Met Leu Xaa Pro Asp 
        35                  40                  45              


Asp Ile Glu Gln Trp Phe Xaa Glu Asp Pro Gly Pro 
    50                  55                  60  


<210>  71
<211>  60
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  71

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
1               5                   10                  15      


Trp Ile Gly Xaa Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
            20                  25                  30          


Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
        35                  40                  45              


Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu 
    50                  55                  60  


<210>  72
<211>  59
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa can be any naturally occurring amino acid

<400>  72

Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp 
1               5                   10                  15      


Ile Gly Xaa Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln Lys 
            20                  25                  30          


Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ser 
        35                  40                  45              


Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu 
    50                  55                  


<210>  73
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<400>  73

Pro Ala Val Arg Pro Thr Phe Arg Val Leu Val Gly Glu Val Glu Gln 
1               5                   10                  15      


Ile Val Ser Ala Leu Leu Gly Asp His Tyr Val Gln Leu Pro Ala Thr 
            20                  25                  30          


Tyr Met Asn Leu Gly Pro Ser Thr Ser His Glu Met Asn Val Arg Pro 
        35                  40                  45              


Glu Gln Pro Gln Phe Ser Pro Met Pro Gly Asn Val Arg Arg Pro Arg 
    50                  55                  60                  


Pro Leu Xaa Glu Pro Pro Arg Pro Thr 
65                  70              


<210>  74
<211>  56
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<400>  74

Tyr Xaa Pro Thr Ser Pro Asn Tyr Xaa Pro Thr Ser Pro Asn Tyr Thr 
1               5                   10                  15      


Pro Thr Ser Pro Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr 
            20                  25                  30          


Ser Pro Asn Tyr Thr Pro Thr Ser Pro Asn Tyr Xaa Pro Thr Ser Pro 
        35                  40                  45              


Ser Tyr Xaa Pro Thr Ser Pro Ser 
    50                  55      


<210>  75
<211>  84
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (24)..(24)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (28)..(28)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid

<400>  75

His Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile 
1               5                   10                  15      


Pro Gly Gly Asn Ile Tyr Ile Xaa Pro Leu Lys Xaa Pro Tyr Lys Ile 
            20                  25                  30          


Ser Glu Gly Leu Pro Xaa Pro Thr Lys Met Xaa Pro Arg Ser Arg Ile 
        35                  40                  45              


Leu Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys 
    50                  55                  60                  


Ile Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala 
65                  70                  75                  80  


Glu Gly Ser Asn 
                


<210>  76
<211>  236
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (121)..(121)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (129)..(129)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (167)..(167)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (190)..(190)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (197)..(197)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (213)..(213)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (215)..(215)
<223>  Xaa can be any naturally occurring amino acid

<400>  76

Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly Ser 
1               5                   10                  15      


Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu Leu 
            20                  25                  30          


Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Xaa Pro 
        35                  40                  45              


Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser Gly 
    50                  55                  60                  


Gly Xaa Pro Lys Cys Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly Glu 
65                  70                  75                  80  


Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp Leu Asp Glu Thr Gly 
                85                  90                  95      


His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met Asn 
            100                 105                 110         


His Asp Gln His Leu Met Lys Cys Xaa Pro Ala Gln Leu Leu Cys Ser 
        115                 120                 125             


Xaa Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met Cys 
    130                 135                 140                 


Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp Ser 
145                 150                 155                 160 


Glu Met Lys Tyr Leu Gly Xaa Pro Ile Thr Thr Val Pro Lys Leu Asp 
                165                 170                 175     


Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Xaa Asp Glu 
            180                 185                 190         


Leu Met Glu Phe Xaa Leu Lys Asp Gln Glu Ala Lys Val Ser Arg Ser 
        195                 200                 205             


Gly Leu Tyr Arg Xaa Pro Xaa Met Pro Glu Asn Leu Asn Arg Pro Arg 
    210                 215                 220                 


Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Thr Ile 
225                 230                 235     


<210>  77
<211>  237
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (122)..(122)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (130)..(130)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (168)..(168)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (191)..(191)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (198)..(198)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (214)..(214)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (216)..(216)
<223>  Xaa can be any naturally occurring amino acid

<400>  77

Met Ser Thr Glu Leu Phe Ser Ser Thr Arg Glu Glu Gly Ser Ser Gly 
1               5                   10                  15      


Ser Gly Pro Ser Phe Arg Ser Asn Gln Arg Lys Met Leu Asn Leu Leu 
            20                  25                  30          


Leu Glu Arg Asp Thr Ser Phe Thr Val Cys Pro Asp Val Pro Arg Xaa 
        35                  40                  45              


Pro Val Gly Lys Phe Leu Gly Asp Ser Ala Asn Leu Ser Ile Leu Ser 
    50                  55                  60                  


Gly Gly Xaa Pro Lys Cys Cys Leu Asp Leu Ser Asn Leu Ser Ser Gly 
65                  70                  75                  80  


Glu Ile Thr Ala Thr Gln Leu Thr Thr Ser Ala Asp Leu Asp Glu Thr 
                85                  90                  95      


Gly His Leu Asp Ser Ser Gly Leu Gln Glu Val His Leu Ala Gly Met 
            100                 105                 110         


Asn His Asp Gln His Leu Met Lys Cys Xaa Pro Ala Gln Leu Leu Cys 
        115                 120                 125             


Ser Xaa Pro Asn Gly Leu Asp Arg Gly His Arg Lys Arg Asp Ala Met 
    130                 135                 140                 


Cys Ser Ser Ser Ala Asn Lys Glu Asn Asp Asn Gly Asn Leu Val Asp 
145                 150                 155                 160 


Ser Glu Met Lys Tyr Leu Gly Xaa Pro Ile Thr Thr Val Pro Lys Leu 
                165                 170                 175     


Asp Lys Asn Pro Asn Leu Gly Glu Asp Gln Ala Glu Glu Ile Xaa Asp 
            180                 185                 190         


Glu Leu Met Glu Phe Xaa Leu Lys Asp Gln Glu Ala Lys Val Ser Arg 
        195                 200                 205             


Ser Gly Leu Tyr Arg Xaa Pro Xaa Met Pro Glu Asn Leu Asn Arg Pro 
    210                 215                 220                 


Arg Leu Lys Gln Val Glu Lys Phe Lys Asp Asn Thr Ile 
225                 230                 235         


<210>  78
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (90)..(90)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (96)..(96)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (102)..(102)
<223>  Xaa can be any naturally occurring amino acid

<400>  78

Met Ser Cys Thr Arg Met Ile Gln Val Leu Asp Pro Arg Pro Leu Thr 
1               5                   10                  15      


Ser Ser Val Met Pro Val Asp Val Ala Met Arg Leu Cys Leu Ala His 
            20                  25                  30          


Ser Pro Pro Val Lys Ser Phe Leu Gly Pro Tyr Asp Glu Phe Gln Arg 
        35                  40                  45              


Arg His Phe Val Asn Lys Leu Lys Pro Leu Lys Ser Cys Leu Asn Ile 
    50                  55                  60                  


Lys His Lys Ala Lys Ser Gln Asn Asp Trp Lys Cys Ser His Asn Gln 
65                  70                  75                  80  


Ala Lys Lys Arg Val Val Phe Ala Asp Xaa Lys Gly Leu Xaa Leu Xaa 
                85                  90                  95      


Ala Ile His Val Phe Xaa Asp Leu Pro Glu Glu 
            100                 105         


<210>  79
<211>  106
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (89)..(89)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (95)..(95)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (101)..(101)
<223>  Xaa can be any naturally occurring amino acid

<400>  79

Ser Cys Thr Arg Met Ile Gln Val Leu Asp Pro Arg Pro Leu Thr Ser 
1               5                   10                  15      


Ser Val Met Pro Val Asp Val Ala Met Arg Leu Cys Leu Ala His Ser 
            20                  25                  30          


Pro Pro Val Lys Ser Phe Leu Gly Pro Tyr Asp Glu Phe Gln Arg Arg 
        35                  40                  45              


His Phe Val Asn Lys Leu Lys Pro Leu Lys Ser Cys Leu Asn Ile Lys 
    50                  55                  60                  


His Lys Ala Lys Ser Gln Asn Asp Trp Lys Cys Ser His Asn Gln Ala 
65                  70                  75                  80  


Lys Lys Arg Val Val Phe Ala Asp Xaa Lys Gly Leu Xaa Leu Xaa Ala 
                85                  90                  95      


Ile His Val Phe Xaa Asp Leu Pro Glu Glu 
            100                 105     


<210>  80
<211>  23
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (15)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  80

Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa Xaa 
1               5                   10                  15      


Ile Glu Met Pro Gln Gln Ala 
            20              


<210>  81
<211>  24
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  81

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala 
            20                  


<210>  82
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (23)..(23)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (30)..(30)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (58)..(58)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (65)..(65)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (79)..(79)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (86)..(86)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (93)..(93)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (107)..(107)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (114)..(114)
<223>  Xaa can be any naturally occurring amino acid

<400>  82

Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa 
1               5                   10                  15      


Pro Thr Ser Pro Asn Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr 
            20                  25                  30          


Ser Pro Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr Ser Pro 
        35                  40                  45              


Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr 
    50                  55                  60                  


Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro 
65                  70                  75                  80  


Thr Ser Pro Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr Ser 
                85                  90                  95      


Pro Ser Tyr Xaa Pro Thr Ser Pro Ser Tyr Xaa Pro Thr Ser Pro Ser 
            100                 105                 110         


Tyr Xaa Pro Thr 
        115     


<210>  83
<211>  351
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (161)..(161)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (178)..(178)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (199)..(199)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (204)..(204)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (264)..(264)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (335)..(335)
<223>  Xaa can be any naturally occurring amino acid

<400>  83

Met Ala Ala Ala Ala Asn Ser Gly Ser Ser Leu Pro Leu Phe Asp Cys 
1               5                   10                  15      


Pro Thr Trp Ala Gly Lys Pro Pro Pro Gly Leu His Leu Asp Val Val 
            20                  25                  30          


Lys Gly Asp Lys Leu Ile Glu Lys Leu Ile Ile Asp Glu Lys Lys Tyr 
        35                  40                  45              


Tyr Leu Phe Gly Arg Asn Pro Asp Leu Cys Asp Phe Thr Ile Asp His 
    50                  55                  60                  


Gln Ser Cys Ser Arg Val His Ala Ala Leu Val Tyr His Lys His Leu 
65                  70                  75                  80  


Lys Arg Val Phe Leu Ile Asp Leu Asn Ser Thr His Gly Thr Phe Leu 
                85                  90                  95      


Gly His Ile Arg Leu Glu Pro His Lys Pro Gln Gln Ile Pro Ile Asp 
            100                 105                 110         


Ser Thr Val Ser Phe Gly Ala Ser Thr Arg Ala Tyr Thr Leu Arg Glu 
        115                 120                 125             


Lys Pro Gln Thr Leu Pro Ser Ala Val Lys Gly Asp Glu Lys Met Gly 
    130                 135                 140                 


Gly Glu Asp Asp Glu Leu Lys Gly Leu Leu Gly Leu Pro Glu Glu Glu 
145                 150                 155                 160 


Xaa Glu Leu Asp Asn Leu Thr Glu Phe Asn Thr Ala His Asn Lys Arg 
                165                 170                 175     


Ile Xaa Thr Leu Thr Ile Glu Glu Gly Asn Leu Asp Ile Gln Arg Pro 
            180                 185                 190         


Lys Arg Lys Arg Lys Asn Xaa Arg Val Thr Phe Xaa Glu Asp Asp Glu 
        195                 200                 205             


Ile Ile Asn Pro Glu Asp Val Asp Pro Ser Val Gly Arg Phe Arg Asn 
    210                 215                 220                 


Met Val Gln Thr Ala Val Val Pro Val Lys Lys Lys Arg Val Glu Gly 
225                 230                 235                 240 


Pro Gly Ser Leu Gly Leu Glu Glu Ser Gly Ser Arg Arg Met Gln Asn 
                245                 250                 255     


Phe Ala Phe Ser Gly Gly Leu Xaa Gly Gly Leu Pro Pro Thr His Ser 
            260                 265                 270         


Glu Ala Gly Ser Gln Pro His Gly Ile His Gly Thr Ala Leu Ile Gly 
        275                 280                 285             


Gly Leu Pro Met Pro Tyr Pro Asn Leu Ala Pro Asp Val Asp Leu Thr 
    290                 295                 300                 


Pro Val Val Pro Ser Ala Val Asn Met Asn Pro Ala Pro Asn Pro Ala 
305                 310                 315                 320 


Val Tyr Asn Pro Glu Ala Val Asn Glu Pro Lys Lys Lys Lys Xaa Ala 
                325                 330                 335     


Lys Glu Ala Trp Pro Gly Lys Lys Pro Thr Pro Ser Leu Leu Ile 
            340                 345                 350     


<210>  84
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Asp Gln Thr Pro Pro Ala Arg Pro Glu Tyr Leu Val Ser Gly Ile 
1               5                   10                  15      


Arg Thr Pro Pro Val Arg Arg Asn Ser Lys Leu Ala Thr Leu Gly Arg 
            20                  25                  30          


Ile Phe Lys Pro Trp Lys Trp Arg Lys Lys Lys Asn Glu Lys Leu Lys 
        35                  40                  45              


Gln Thr Thr Ser Ala Leu Glu Lys Lys Met Ala Gly Arg Gln Gly Arg 
    50                  55                  60                  


Glu Glu Leu Ile Lys Lys Gly Leu Leu Glu Met Met Glu Gln Asp Ala 
65                  70                  75                  80  


Glu Ser Lys Thr Cys Asn Pro Asp Gly Gly Pro Arg Ser Val Gln Ser 
                85                  90                  95      


Glu Pro Pro Thr Pro Lys Ser Glu Thr Leu Thr Ser Glu Asp Ala Gln 
            100                 105                 110         


Pro Gly Ser Pro Leu Ala Thr Gly Thr Asp Gln Val Ser Leu Asp Lys 
        115                 120                 125             


Pro Leu Ser Ser Ala Ala His Leu Asp Asp Ala Ala Lys Met Pro Ser 
    130                 135                 140                 


Ala Ser Ser Gly Glu Glu Ala Asp Ala Gly Ser Leu Leu Pro Thr Thr 
145                 150                 155                 160 


Asn Glu Leu Ser Gln Ala Leu Ala Gly Ala Asp Ser Leu Asp Ser Pro 
                165                 170                 175     


Pro Arg Pro Leu Glu Arg Ser Val Gly Gln Leu Pro Ser Pro Pro Leu 
            180                 185                 190         


Leu Pro Thr Pro Pro Pro Lys Ala Ser Ser Lys Thr Thr Lys Asn Val 
        195                 200                 205             


Thr Gly Gln Ala Thr Leu Phe Gln Ala Ser Ser Met Lys Ser Ala Asp 
    210                 215                 220                 


Pro Ser Leu Arg Gly Gln Leu Ser Thr Pro Thr Gly Ser Pro His Leu 
225                 230                 235                 240 


Thr Thr Val His Arg Pro Leu Pro Pro Ser Arg Val Ile Glu Glu Leu 
                245                 250                 255     


His Arg Ala Leu Ala Thr Lys His Arg Gln Asp Ser Phe Gln Gly Arg 
            260                 265                 270         


Glu Ser Lys Gly Ser Pro Lys Arg Arg Leu Asp Val Arg Leu Ser Arg 
        275                 280                 285             


Thr Ser Ser Val Glu Arg Gly Lys Glu Arg Glu Glu Ala Trp Ser Phe 
    290                 295                 300                 


Asp Gly Ala Leu Glu Asn Lys Arg Thr Ala Ala Lys Glu Ser Glu Glu 
305                 310                 315                 320 


Asn Lys Glu Asn Leu Ile Ile Asn Ser Glu Leu Lys Asp Asp Leu Leu 
                325                 330                 335     


Leu Tyr Gln Asp Glu Glu Ala Leu Asn Asp Ser Ile Ile Ser Gly Thr 
            340                 345                 350         


Leu Pro Arg Lys Cys Arg Lys Glu Leu Leu Ala Val Lys Leu Arg Asn 
        355                 360                 365             


Arg Pro Ser Lys Gln Glu Leu Glu Asp Arg Asn Ile Phe Pro Arg Arg 
    370                 375                 380                 


Thr Asp Glu Glu Arg Gln Glu Ile Arg Gln Gln Ile Glu Met Lys Leu 
385                 390                 395                 400 


Ser Lys Arg Leu Ser Gln Arg Pro Ala Val Glu Glu Leu Glu Arg Arg 
                405                 410                 415     


Asn Ile Leu Lys Gln Arg Asn Asp Gln Thr Glu Gln Glu Glu Arg Arg 
            420                 425                 430         


Glu Ile Lys Gln Arg Leu Thr Arg Lys Leu Asn Gln Arg Pro Thr Val 
        435                 440                 445             


Asp Glu Leu Arg Asp Arg Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val 
    450                 455                 460                 


Glu Val Ala Lys Ala Gln Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp 
465                 470                 475                 480 


Thr Arg Leu Ser Ala Ala Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn 
                485                 490                 495     


Glu Tyr Lys Ser Asn Glu Met Glu Val His Ala Ser Ser Lys His Leu 
            500                 505                 510         


Thr Arg Phe His Arg Pro 
        515             


<210>  85
<211>  147
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  85

Met Ala Ala Gln Arg Leu Gly Lys Arg Val Leu Ser Lys Leu Gln Ser 
1               5                   10                  15      


Pro Ser Arg Ala Arg Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys 
            20                  25                  30          


Arg His Ala Arg Val Xaa Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg 
        35                  40                  45              


Arg Leu Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr 
    50                  55                  60                  


Arg Gly Met Glu Ala Asp Met Pro Asp Glu Ile Asn Ile Asp Glu Leu 
65                  70                  75                  80  


Leu Glu Leu Glu Ser Glu Glu Glu Arg Ser Arg Lys Ile Gln Gly Leu 
                85                  90                  95      


Leu Lys Ser Cys Gly Lys Pro Val Glu Asp Phe Ile Gln Glu Leu Leu 
            100                 105                 110         


Ala Lys Leu Gln Gly Leu His Arg Gln Pro Gly Leu Arg Gln Pro Ser 
        115                 120                 125             


Pro Ser His Asp Gly Ser Leu Ser Pro Leu Gln Asp Arg Ala Arg Thr 
    130                 135                 140                 


Ala His Pro 
145         


<210>  86
<211>  204
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  86

Met Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro 
1               5                   10                  15      


Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Xaa Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu 
        35                  40                  45              


Glu Glu Ala Ser Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu 
    50                  55                  60                  


Lys Ser Lys Arg Pro Asn Pro Cys Ala Tyr Xaa Pro Pro Ser Leu Lys 
65                  70                  75                  80  


Ala Val Gln Arg Ile Ala Glu Ser His Leu Gln Ser Ile Ser Asn Leu 
                85                  90                  95      


Asn Glu Asn Gln Ala Ser Glu Glu Glu Asp Glu Leu Gly Glu Leu Arg 
            100                 105                 110         


Glu Leu Gly Tyr Pro Arg Glu Glu Asp Glu Glu Glu Glu Glu Asp Asp 
        115                 120                 125             


Glu Glu Glu Glu Glu Glu Glu Asp Ser Gln Ala Glu Val Leu Lys Val 
    130                 135                 140                 


Ile Arg Gln Ser Ala Gly Gln Lys Thr Thr Cys Gly Gln Gly Leu Glu 
145                 150                 155                 160 


Gly Pro Trp Glu Arg Pro Pro Pro Leu Asp Glu Ser Glu Arg Asp Gly 
                165                 170                 175     


Gly Ser Glu Asp Gln Val Glu Asp Pro Ala Leu Ser Glu Pro Gly Glu 
            180                 185                 190         


Glu Pro Gln Arg Pro Ser Pro Ser Glu Pro Gly Thr 
        195                 200                 


<210>  87
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp 
1               5                   10                  15      


Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser 
            20                  25                  30          


Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys 
        35                  40                  45              


Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val 
    50                  55                  60                  


Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr 
65                  70                  75                  80  


Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu 
                85                  90                  95      


Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn 
            100                 105                 110         


Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu 
        115                 120                 125             


Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile 
    130                 135                 140                 


Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg 
145                 150                 155                 160 


Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr 
                165                 170                 175     


Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg 
            180                 185                 190         


Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe 
        195                 200                 205             


Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys 
    210                 215                 220                 


Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro 
225                 230                 235                 240 


Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr 
                245                 250                 255     


Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala 
            260                 265                 270         


Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly 
        275                 280                 285             


Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys 
    290                 295                 300                 


Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser 
305                 310                 315                 320 


Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser 
                325                 330                 335     


Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro 
            340                 345                 350         


Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala 
        355                 360                 365             


Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly 
    370                 375                 380                 


Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr 
385                 390                 395                 400 


Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp 
                405                 410                 415     


Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala 
            420                 425                 430         


Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg 
        435                 440                 445             


Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro 
    450                 455                 460                 


Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser 
465                 470                 475                 480 


Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu 
                485                 490                 495     


Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr 
            500                 505                 510         


Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met 
        515                 520                 525             


Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn 
545                 550                 555                 560 


Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly 
                565                 570                 575     


Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro 
            580                 585                 590         


Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp 
        595                 600                 605             


Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro 
    610                 615                 620                 


Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met 
625                 630                 635                 640 


Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly 
                645                 650                 655     


Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro 
            660                 665                 670         


Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg 
        675                 680                 685             


Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His 
    690                 695                 700                 


Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn 
                725                 730                 735     


Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg 
            740                 745                 750         


Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg 
        755                 760                 765             


Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His 
    770                 775                 780                 


Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His 
785                 790                 795                 800 


Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His 
                805                 810                 815     


Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His 
            820                 825                 830         


Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His 
        835                 840                 845             


Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val 
    850                 855                 860                 


Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His 
865                 870                 875                 880 


Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His 
                885                 890                 895     


Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys 
            900                 905                 910         


Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala 
        915                 920                 925             


Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro 
    930                 935                 940 


<210>  88
<211>  171
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  88

Met Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu 
1               5                   10                  15      


Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
            20                  25                  30          


Arg Pro Xaa Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
        35                  40                  45              


Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
    50                  55                  60                  


Ala Met Xaa Pro Arg Gln Arg Lys Lys Met Xaa Arg Ile Thr Pro Thr 
65                  70                  75                  80  


Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                85                  90                  95      


Gln Gly Glu Glu Pro Glu Gly Ala Ala Glu Ser Thr Gly Thr Gln Glu 
            100                 105                 110         


Ser Arg Pro Pro Gly Ile Pro Asp Thr Glu Val Glu Ser Arg Leu Gly 
        115                 120                 125             


Thr Ser Gly Thr Ala Lys Lys Thr Ala Glu Cys Ile Pro Lys Thr His 
    130                 135                 140                 


Glu Arg Gly Ser Lys Glu Pro Ser Thr Lys Glu Pro Ser Thr His Ile 
145                 150                 155                 160 


Pro Pro Leu Asp Ser Lys Gly Ala Asn Ser Val 
                165                 170     


<210>  89
<211>  815
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<400>  89

Met Met Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser Ala 
1               5                   10                  15      


Ser Pro His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys Pro 
            20                  25                  30          


Pro Asp Ala Pro Gly Pro Asp Glu Ala Pro Lys Gly Ala His His Lys 
        35                  40                  45              


Lys Tyr Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln Met 
    50                  55                  60                  


Gly Thr Thr Ala Gly Pro Ser Gly Glu Ala Gly Gly Gly Ala Gly Leu 
65                  70                  75                  80  


Ala Glu Ala Pro Arg Ala Ser Glu Arg Gly Val Arg Leu Xaa Leu Pro 
                85                  90                  95      


Arg Ala Ser Xaa Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu Lys 
            100                 105                 110         


Leu Gly Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys Pro 
        115                 120                 125             


Ala Pro Ser Ala Gln Pro Ala Pro Pro Pro His Pro Pro Ser Arg Leu 
    130                 135                 140                 


Gln Glu Thr Arg Lys Leu Phe Glu Arg Ser Ala Pro Ala Ala Gly Gly 
145                 150                 155                 160 


Asp Lys Glu Ala Ala Arg Arg Leu Leu Arg Gln Glu Arg Ala Gly Leu 
                165                 170                 175     


Gln Asp Arg Lys Leu Asp Val Val Val Arg Phe Asn Gly Ser Thr Glu 
            180                 185                 190         


Ala Leu Asp Lys Leu Asp Ala Asp Ala Val Ser Pro Thr Val Ser Gln 
        195                 200                 205             


Leu Ser Ala Val Phe Glu Lys Ala Asp Ser Arg Thr Gly Leu His Arg 
    210                 215                 220                 


Gly Pro Gly Leu Pro Arg Ala Ala Gly Val Pro Gln Val Asn Ser Lys 
225                 230                 235                 240 


Leu Val Ser Lys Arg Ser Arg Val Phe Gln Pro Pro Pro Pro Pro Pro 
                245                 250                 255     


Pro Ala Pro Ser Gly Asp Ala Pro Ala Glu Lys Glu Arg Cys Pro Ala 
            260                 265                 270         


Gly Gln Gln Pro Pro Gln His Arg Val Ala Pro Ala Arg Pro Pro Pro 
        275                 280                 285             


Lys Pro Arg Glu Val Arg Lys Ile Lys Pro Val Glu Val Glu Glu Ser 
    290                 295                 300                 


Gly Glu Ser Glu Ala Glu Ser Ala Pro Gly Glu Val Ile Gln Ala Glu 
305                 310                 315                 320 


Val Thr Val His Ala Ala Leu Glu Asn Gly Ser Thr Val Ala Thr Ala 
                325                 330                 335     


Ala Ser Pro Ala Pro Glu Glu Pro Lys Ala Gln Ala Ala Pro Glu Lys 
            340                 345                 350         


Glu Ala Ala Ala Val Ala Pro Pro Glu Arg Gly Val Gly Asn Gly Arg 
        355                 360                 365             


Ala Pro Asp Val Ala Pro Glu Glu Val Asp Glu Ser Lys Lys Glu Asp 
    370                 375                 380                 


Phe Ser Glu Ala Asp Leu Val Asp Val Ser Ala Tyr Ser Gly Leu Gly 
385                 390                 395                 400 


Glu Asp Ser Ala Gly Ser Ala Leu Glu Glu Asp Asp Glu Asp Asp Glu 
                405                 410                 415     


Glu Asp Gly Glu Pro Pro Tyr Glu Pro Glu Ser Gly Cys Val Glu Ile 
            420                 425                 430         


Pro Gly Leu Ser Glu Glu Glu Asp Pro Ala Pro Ser Arg Lys Ile His 
        435                 440                 445             


Phe Ser Thr Ala Pro Ile Gln Val Phe Ser Thr Tyr Ser Asn Glu Asp 
    450                 455                 460                 


Tyr Asp Arg Arg Asn Glu Asp Val Asp Pro Met Ala Ala Ser Ala Glu 
465                 470                 475                 480 


Tyr Glu Leu Glu Lys Arg Val Glu Arg Leu Glu Leu Phe Pro Val Glu 
                485                 490                 495     


Leu Glu Lys Asp Ser Glu Gly Leu Gly Ile Ser Ile Ile Gly Met Gly 
            500                 505                 510         


Ala Gly Ala Asp Met Gly Leu Glu Lys Leu Gly Ile Phe Val Lys Thr 
        515                 520                 525             


Val Thr Glu Gly Gly Ala Ala His Arg Asp Gly Arg Ile Gln Val Asn 
    530                 535                 540                 


Asp Leu Leu Val Glu Val Asp Gly Thr Ser Leu Val Gly Val Thr Gln 
545                 550                 555                 560 


Ser Phe Ala Ala Ser Val Leu Arg Asn Thr Lys Gly Arg Val Arg Phe 
                565                 570                 575     


Met Ile Gly Arg Glu Arg Pro Gly Glu Gln Ser Glu Val Ala Gln Leu 
            580                 585                 590         


Ile Gln Gln Thr Leu Glu Gln Glu Arg Trp Gln Arg Glu Met Met Glu 
        595                 600                 605             


Gln Arg Tyr Ala Gln Tyr Gly Glu Asp Asp Glu Glu Thr Gly Glu Tyr 
    610                 615                 620                 


Ala Thr Asp Glu Asp Glu Glu Leu Ser Pro Thr Phe Pro Gly Gly Glu 
625                 630                 635                 640 


Met Ala Ile Glu Val Phe Glu Leu Ala Glu Asn Glu Asp Ala Leu Ser 
                645                 650                 655     


Pro Val Asp Met Glu Pro Glu Lys Leu Val His Lys Phe Lys Glu Leu 
            660                 665                 670         


Gln Ile Lys His Ala Val Thr Glu Ala Glu Ile Gln Gln Leu Lys Arg 
        675                 680                 685             


Lys Leu Gln Ser Leu Glu Gln Glu Lys Gly Arg Trp Arg Val Glu Lys 
    690                 695                 700                 


Ala Gln Leu Glu Gln Ser Val Glu Glu Asn Lys Glu Arg Met Glu Lys 
705                 710                 715                 720 


Leu Glu Gly Tyr Trp Gly Glu Ala Gln Ser Leu Cys Gln Ala Val Asp 
                725                 730                 735     


Glu His Leu Arg Glu Thr Gln Ala Gln Tyr Gln Ala Leu Glu Arg Lys 
            740                 745                 750         


Tyr Ser Lys Ala Lys Arg Leu Ile Lys Asp Tyr Gln Gln Lys Glu Ile 
        755                 760                 765             


Glu Phe Leu Lys Lys Glu Thr Ala Gln Arg Arg Val Leu Glu Glu Ser 
    770                 775                 780                 


Glu Leu Ala Arg Lys Glu Glu Met Asp Lys Leu Leu Asp Lys Ile Ser 
785                 790                 795                 800 


Glu Leu Glu Gly Asn Leu Gln Thr Leu Arg Asn Ser Asn Ser Thr 
                805                 810                 815 


<210>  90
<211>  1098
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (371)..(371)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (461)..(461)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (915)..(915)
<223>  Xaa can be any naturally occurring amino acid

<400>  90

Met Leu Lys Thr Glu Ser Ser Gly Glu Arg Thr Thr Leu Arg Ser Ala 
1               5                   10                  15      


Ser Pro His Arg Asn Ala Tyr Arg Thr Glu Phe Gln Ala Leu Lys Ser 
            20                  25                  30          


Thr Phe Asp Lys Pro Lys Ser Asp Gly Glu Gln Lys Thr Lys Glu Gly 
        35                  40                  45              


Glu Gly Ser Gln Gln Ser Arg Gly Arg Lys Tyr Gly Ser Asn Val Asn 
    50                  55                  60                  


Arg Ile Lys Asn Leu Phe Met Gln Met Gly Met Glu Pro Asn Glu Asn 
65                  70                  75                  80  


Ala Ala Val Ile Ala Lys Thr Arg Gly Lys Gly Gly His Ser Ser Pro 
                85                  90                  95      


Gln Arg Arg Met Lys Pro Lys Glu Phe Leu Glu Lys Thr Asp Gly Ser 
            100                 105                 110         


Val Val Lys Leu Glu Ser Ser Val Ser Glu Arg Ile Ser Arg Phe Asp 
        115                 120                 125             


Thr Met Tyr Asp Gly Pro Ser Tyr Ser Lys Phe Thr Glu Thr Arg Lys 
    130                 135                 140                 


Met Phe Glu Arg Ser Val His Glu Ser Gly Gln Asn Asn Arg Tyr Ser 
145                 150                 155                 160 


Pro Lys Lys Glu Lys Ala Gly Gly Ser Glu Pro Gln Asp Glu Trp Gly 
                165                 170                 175     


Gly Ser Lys Ser Asn Arg Gly Ser Thr Asp Ser Leu Asp Ser Leu Ser 
            180                 185                 190         


Ser Arg Thr Glu Ala Val Ser Pro Thr Val Ser Gln Leu Ser Ala Val 
        195                 200                 205             


Phe Glu Asn Thr Asp Ser Pro Ser Ala Ile Ile Ser Glu Lys Ala Glu 
    210                 215                 220                 


Asn Asn Glu Tyr Ser Val Thr Gly His Tyr Pro Leu Asn Leu Pro Ser 
225                 230                 235                 240 


Val Thr Val Thr Asn Leu Asp Thr Phe Gly His Leu Lys Asp Ser Asn 
                245                 250                 255     


Ser Trp Pro Pro Ser Asn Lys Arg Gly Val Asp Thr Glu Asp Ala His 
            260                 265                 270         


Lys Ser Asn Ala Thr Pro Val Pro Glu Val Ala Ser Lys Ser Thr Ser 
        275                 280                 285             


Leu Ala Ser Ile Pro Gly Glu Glu Ile Gln Gln Ser Lys Glu Pro Glu 
    290                 295                 300                 


Asp Ser Thr Ser Asn Gln Gln Thr Pro Asp Ser Ile Asp Lys Asp Gly 
305                 310                 315                 320 


Pro Glu Glu Pro Cys Ala Glu Ser Lys Ala Met Pro Lys Ser Glu Ile 
                325                 330                 335     


Pro Ser Pro Gln Ser Gln Leu Leu Glu Asp Ala Glu Ala Asn Leu Val 
            340                 345                 350         


Gly Arg Glu Ala Ala Lys Gln Gln Arg Lys Glu Leu Ala Gly Gly Asp 
        355                 360                 365             


Phe Thr Xaa Pro Asp Ala Ser Ala Ser Ser Cys Gly Lys Glu Val Pro 
    370                 375                 380                 


Glu Asp Ser Asn Asn Phe Asp Gly Ser His Val Tyr Met His Ser Asp 
385                 390                 395                 400 


Tyr Asn Val Tyr Arg Val Arg Ser Arg Tyr Asn Ser Asp Trp Gly Glu 
                405                 410                 415     


Thr Gly Thr Glu Gln Asp Glu Glu Glu Asp Ser Asp Glu Asn Ser Tyr 
            420                 425                 430         


Tyr Gln Pro Asp Met Glu Tyr Ser Glu Ile Val Gly Leu Pro Glu Glu 
        435                 440                 445             


Glu Glu Ile Pro Ala Asn Arg Lys Ile Lys Phe Ser Xaa Ala Pro Ile 
    450                 455                 460                 


Lys Val Phe Asn Thr Tyr Ser Asn Glu Asp Tyr Asp Arg Arg Asn Asp 
465                 470                 475                 480 


Glu Val Asp Pro Val Ala Ala Ser Ala Glu Tyr Glu Leu Glu Lys Arg 
                485                 490                 495     


Val Glu Lys Leu Glu Leu Phe Pro Val Glu Leu Glu Lys Asp Glu Asp 
            500                 505                 510         


Gly Leu Gly Ile Ser Ile Ile Gly Met Gly Val Gly Ala Asp Ala Gly 
        515                 520                 525             


Leu Glu Lys Leu Gly Ile Phe Val Lys Thr Val Thr Glu Gly Gly Ala 
    530                 535                 540                 


Ala Gln Arg Asp Gly Arg Ile Gln Val Asn Asp Gln Ile Val Glu Val 
545                 550                 555                 560 


Asp Gly Ile Ser Leu Val Gly Val Thr Gln Asn Phe Ala Ala Thr Val 
                565                 570                 575     


Leu Arg Asn Thr Lys Gly Asn Val Arg Phe Val Ile Gly Arg Glu Lys 
            580                 585                 590         


Pro Gly Gln Val Ser Glu Val Ala Gln Leu Ile Ser Gln Thr Leu Glu 
        595                 600                 605             


Gln Glu Arg Arg Gln Arg Glu Leu Leu Glu Gln His Tyr Ala Gln Tyr 
    610                 615                 620                 


Asp Ala Asp Asp Asp Glu Thr Gly Glu Tyr Ala Thr Asp Glu Glu Glu 
625                 630                 635                 640 


Asp Glu Val Gly Pro Val Leu Pro Gly Ser Asp Met Ala Ile Glu Val 
                645                 650                 655     


Phe Glu Leu Pro Glu Asn Glu Asp Met Phe Ser Pro Ser Glu Leu Asp 
            660                 665                 670         


Thr Ser Lys Leu Ser His Lys Phe Lys Glu Leu Gln Ile Lys His Ala 
        675                 680                 685             


Val Thr Glu Ala Glu Ile Gln Lys Leu Lys Thr Lys Leu Gln Ala Ala 
    690                 695                 700                 


Glu Asn Glu Lys Val Arg Trp Glu Leu Glu Lys Thr Gln Leu Gln Gln 
705                 710                 715                 720 


Asn Ile Glu Glu Asn Lys Glu Arg Met Leu Lys Leu Glu Ser Tyr Trp 
                725                 730                 735     


Ile Glu Ala Gln Thr Leu Cys His Thr Val Asn Glu His Leu Lys Glu 
            740                 745                 750         


Thr Gln Ser Gln Tyr Gln Ala Leu Glu Lys Lys Tyr Asn Lys Ala Lys 
        755                 760                 765             


Lys Leu Ile Lys Asp Phe Gln Gln Lys Glu Leu Asp Phe Ile Lys Arg 
    770                 775                 780                 


Gln Glu Ala Glu Arg Lys Lys Ile Glu Asp Leu Glu Lys Ala His Leu 
785                 790                 795                 800 


Val Glu Val Gln Gly Leu Gln Val Arg Ile Arg Asp Leu Glu Ala Glu 
                805                 810                 815     


Val Phe Arg Leu Leu Lys Gln Asn Gly Thr Gln Val Asn Asn Asn Asn 
            820                 825                 830         


Asn Ile Phe Glu Arg Arg Thr Ser Leu Gly Glu Val Ser Lys Gly Asp 
        835                 840                 845             


Thr Met Glu Asn Leu Asp Gly Lys Gln Thr Ser Cys Gln Asp Gly Leu 
    850                 855                 860                 


Ser Gln Asp Leu Asn Glu Ala Val Pro Glu Thr Glu Arg Leu Asp Ser 
865                 870                 875                 880 


Lys Ala Leu Lys Thr Arg Ala Gln Leu Ser Val Lys Asn Arg Arg Gln 
                885                 890                 895     


Arg Pro Ser Arg Thr Arg Leu Tyr Asp Ser Val Ser Ser Thr Asp Gly 
            900                 905                 910         


Glu Asp Xaa Leu Glu Arg Lys Asn Phe Thr Phe Asn Asp Asp Phe Ser 
        915                 920                 925             


Pro Ser Ser Thr Ser Ser Ala Asp Leu Ser Gly Leu Gly Ala Glu Pro 
    930                 935                 940                 


Lys Thr Pro Gly Leu Ser Gln Ser Leu Ala Leu Ser Ser Asp Glu Ser 
945                 950                 955                 960 


Leu Asp Met Ile Asp Asp Glu Ile Leu Asp Asp Gly Gln Ser Pro Lys 
                965                 970                 975     


His Ser Gln Cys Gln Asn Arg Ala Val Gln Glu Trp Ser Val Gln Gln 
            980                 985                 990         


Val Ser His Trp Leu Met Ser Leu  Asn Leu Glu Gln Tyr  Val Ser Glu 
        995                 1000                 1005             


Phe Ser  Ala Gln Asn Ile Thr  Gly Glu Gln Leu Leu  Gln Leu Asp 
    1010                 1015                 1020             


Gly Asn  Lys Leu Lys Ala Leu  Gly Met Thr Ala Ser  Gln Asp Arg 
    1025                 1030                 1035             


Ala Val  Val Lys Lys Lys Leu  Lys Glu Met Lys Met  Ser Leu Glu 
    1040                 1045                 1050             


Lys Ala  Arg Lys Ala Gln Glu  Lys Met Glu Lys Gln  Arg Glu Lys 
    1055                 1060                 1065             


Leu Arg  Arg Lys Glu Gln Glu  Gln Met Gln Arg Lys  Ser Lys Lys 
    1070                 1075                 1080             


Thr Glu  Lys Met Thr Ser Thr  Thr Ala Glu Gly Ala  Gly Glu Gln 
    1085                 1090                 1095             


<210>  91
<211>  205
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (87)..(87)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (121)..(122)
<223>  Xaa can be any naturally occurring amino acid

<400>  91

Met Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys 
1               5                   10                  15      


Asn Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro 
            20                  25                  30          


Arg Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp 
        35                  40                  45              


Glu Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly 
    50                  55                  60                  


Leu Met Lys Ile Asp Glu Pro Ser Xaa Pro Tyr His Ser Met Met Gly 
65                  70                  75                  80  


Asp Asp Glu Asp Ala Cys Xaa Asp Thr Glu Ala Thr Glu Ala Met Ala 
                85                  90                  95      


Pro Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro 
            100                 105                 110         


Lys Tyr Arg Ile Gln Glu Gln Glu Xaa Xaa Gly Glu Glu Asp Ser Asp 
        115                 120                 125             


Leu Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg 
    130                 135                 140                 


Lys Leu His Tyr Asn Glu Gly Leu Asn Ile Lys Leu Ala Arg Gln Leu 
145                 150                 155                 160 


Ile Ser Lys Asp Leu His Asp Asp Asp Glu Asp Glu Glu Met Leu Glu 
                165                 170                 175     


Thr Ala Asp Gly Glu Ser Met Asn Thr Glu Glu Ser Asn Gln Gly Ser 
            180                 185                 190         


Thr Pro Ser Asp Gln Gln Gln Asn Lys Leu Arg Ser Ser 
        195                 200                 205 


<210>  92
<211>  78
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (54)..(54)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (59)..(59)
<223>  Xaa can be any naturally occurring amino acid

<400>  92

Glu Asp Asp Glu Leu Lys Gly Leu Leu Gly Leu Pro Glu Glu Glu Xaa 
1               5                   10                  15      


Glu Leu Asp Asn Leu Thr Glu Phe Asn Thr Ala His Asn Lys Arg Ile 
            20                  25                  30          


Xaa Thr Leu Thr Ile Glu Glu Gly Asn Leu Asp Ile Gln Arg Pro Lys 
        35                  40                  45              


Arg Lys Arg Lys Asn Xaa Arg Val Thr Phe Xaa Glu Asp Asp Glu Ile 
    50                  55                  60                  


Ile Asn Pro Glu Asp Val Asp Pro Ser Val Gly Arg Phe Arg 
65                  70                  75              


<210>  93
<211>  146
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<400>  93

Ala Ala Gln Arg Leu Gly Lys Arg Val Leu Ser Lys Leu Gln Ser Pro 
1               5                   10                  15      


Ser Arg Ala Arg Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys Arg 
            20                  25                  30          


His Ala Arg Val Xaa Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg 
        35                  40                  45              


Leu Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg 
    50                  55                  60                  


Gly Met Glu Ala Asp Met Pro Asp Glu Ile Asn Ile Asp Glu Leu Leu 
65                  70                  75                  80  


Glu Leu Glu Ser Glu Glu Glu Arg Ser Arg Lys Ile Gln Gly Leu Leu 
                85                  90                  95      


Lys Ser Cys Gly Lys Pro Val Glu Asp Phe Ile Gln Glu Leu Leu Ala 
            100                 105                 110         


Lys Leu Gln Gly Leu His Arg Gln Pro Gly Leu Arg Gln Pro Ser Pro 
        115                 120                 125             


Ser His Asp Gly Ser Leu Ser Pro Leu Gln Asp Arg Ala Arg Thr Ala 
    130                 135                 140                 


His Pro 
145     


<210>  94
<211>  147
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  94

Met Ala Ala Gln Arg Leu Gly Lys Arg Val Leu Ser Lys Leu Gln Ser 
1               5                   10                  15      


Pro Ser Arg Ala Arg Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys 
            20                  25                  30          


Arg His Ala Arg Val Xaa Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg 
        35                  40                  45              


Arg Leu Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr 
    50                  55                  60                  


Arg Gly Met Glu Ala Asp Met Pro Asp Glu Ile Asn Ile Asp Glu Leu 
65                  70                  75                  80  


Leu Glu Leu Glu Ser Glu Glu Glu Arg Ser Arg Lys Ile Gln Gly Leu 
                85                  90                  95      


Leu Lys Ser Cys Gly Lys Pro Val Glu Asp Phe Ile Gln Glu Leu Leu 
            100                 105                 110         


Ala Lys Leu Gln Gly Leu His Arg Gln Pro Gly Leu Arg Gln Pro Ser 
        115                 120                 125             


Pro Ser His Asp Gly Ser Leu Ser Pro Leu Gln Asp Arg Ala Arg Thr 
    130                 135                 140                 


Ala His Pro 
145         


<210>  95
<211>  79
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  95

Arg Lys Leu Asn Gln Arg Pro Thr Val Asp Glu Leu Arg Asp Arg Lys 
1               5                   10                  15      


Ile Leu Ile Arg Phe Ser Asp Tyr Val Glu Val Ala Lys Ala Gln Asp 
            20                  25                  30          


Tyr Asp Arg Arg Ala Asp Lys Pro Trp Thr Arg Leu Ser Ala Ala Asp 
        35                  40                  45              


Lys Ala Ala Ile Arg Lys Glu Leu Asn Glu Tyr Lys Ser Asn Glu Met 
    50                  55                  60                  


Glu Val His Ala Ser Ser Lys His Leu Thr Arg Phe His Arg Pro 
65                  70                  75                  


<210>  96
<211>  99
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  96

Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu Leu 
1               5                   10                  15      


Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Xaa Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro Glu 
        35                  40                  45              


Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu Ala 
    50                  55                  60                  


Met Ser Pro Arg Gln Arg Lys Lys Met Thr Arg Ile Thr Pro Thr Met 
65                  70                  75                  80  


Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln Gln 
                85                  90                  95      


Gly Glu Glu 
            


<210>  97
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  97

Met Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu 
1               5                   10                  15      


Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
            20                  25                  30          


Arg Pro Xaa Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
        35                  40                  45              


Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
    50                  55                  60                  


Ala Met Xaa Pro Arg Gln Arg Lys Lys Met Xaa Arg Ile Thr Pro Thr 
65                  70                  75                  80  


Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                85                  90                  95      


Gln Gly Glu Glu 
            100 


<210>  98
<211>  89
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<400>  98

Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro Pro 
1               5                   10                  15      


Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg Pro 
            20                  25                  30          


Xaa Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu Glu 
        35                  40                  45              


Glu Ala Ser Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu Lys 
    50                  55                  60                  


Ser Lys Arg Pro Asn Pro Cys Ala Tyr Xaa Pro Pro Ser Leu Lys Ala 
65                  70                  75                  80  


Val Gln Arg Ile Ala Glu Ser His Leu 
                85                  


<210>  99
<211>  90
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  99

Met Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro 
1               5                   10                  15      


Pro Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Xaa Pro Ala Met Leu Phe Arg Leu Ser Glu His Ser Ser Pro Glu 
        35                  40                  45              


Glu Glu Ala Ser Pro His Gln Arg Ala Ser Gly Glu Gly His His Leu 
    50                  55                  60                  


Lys Ser Lys Arg Pro Asn Pro Cys Ala Tyr Xaa Pro Pro Ser Leu Lys 
65                  70                  75                  80  


Ala Val Gln Arg Ile Ala Glu Ser His Leu 
                85                  90  


<210>  100
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  100

Asp Pro Lys Asp Arg Lys Lys Ile Gln Phe Ser Val Pro Ala Pro Pro 
1               5                   10                  15      


Ser Gln Leu Asp Pro Arg Gln Val Glu Met Ile Arg Arg Arg Arg Pro 
            20                  25                  30          


Xaa Pro Ala 
        35  


<210>  101
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  101

Gly Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val 
1               5                   10                  15      


Thr Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu 
            20                  25                  30          


Asp Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu 
        35                  40                  45              


Ala Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala 
    50                  55                  60                  


Arg Arg 
65      


<210>  102
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (92)..(92)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (98)..(98)
<223>  Xaa can be any naturally occurring amino acid

<400>  102

Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser Ala Ser Pro 
1               5                   10                  15      


His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys Pro Pro Asp 
            20                  25                  30          


Ala Pro Gly Pro Asp Glu Ala Pro Lys Gly Ala His His Lys Lys Tyr 
        35                  40                  45              


Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln Met Gly Thr 
    50                  55                  60                  


Thr Ala Gly Pro Ser Gly Glu Ala Gly Gly Gly Ala Gly Leu Ala Glu 
65                  70                  75                  80  


Ala Pro Arg Ala Ser Glu Arg Gly Val Arg Leu Xaa Leu Pro Arg Ala 
                85                  90                  95      


Ser Xaa Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu Lys Leu Gly 
            100                 105                 110         


Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys 
        115                 120                 125 


<210>  103
<211>  127
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (94)..(94)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (100)..(100)
<223>  Xaa can be any naturally occurring amino acid

<400>  103

Met Met Lys Thr Glu Pro Arg Gly Pro Gly Gly Pro Leu Arg Ser Ala 
1               5                   10                  15      


Ser Pro His Arg Ser Ala Tyr Glu Ala Gly Ile Gln Ala Leu Lys Pro 
            20                  25                  30          


Pro Asp Ala Pro Gly Pro Asp Glu Ala Pro Lys Gly Ala His His Lys 
        35                  40                  45              


Lys Tyr Gly Ser Asn Val His Arg Ile Lys Ser Met Phe Leu Gln Met 
    50                  55                  60                  


Gly Thr Thr Ala Gly Pro Ser Gly Glu Ala Gly Gly Gly Ala Gly Leu 
65                  70                  75                  80  


Ala Glu Ala Pro Arg Ala Ser Glu Arg Gly Val Arg Leu Xaa Leu Pro 
                85                  90                  95      


Arg Ala Ser Xaa Leu Asn Glu Asn Val Asp His Ser Ala Leu Leu Lys 
            100                 105                 110         


Leu Gly Thr Ser Val Ser Glu Arg Val Ser Arg Phe Asp Ser Lys 
        115                 120                 125         


<210>  104
<211>  150
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (73)..(73)
<223>  Xaa can be any naturally occurring amino acid

<400>  104

Met Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys 
1               5                   10                  15      


Asn Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro 
            20                  25                  30          


Arg Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp 
        35                  40                  45              


Glu Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly 
    50                  55                  60                  


Leu Met Lys Ile Asp Glu Pro Ser Xaa Pro Tyr His Ser Met Met Gly 
65                  70                  75                  80  


Asp Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala 
                85                  90                  95      


Pro Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro 
            100                 105                 110         


Lys Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp 
        115                 120                 125             


Leu Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg 
    130                 135                 140                 


Lys Leu His Tyr Asn Glu 
145                 150 


<210>  105
<211>  149
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  105

Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys Asn 
1               5                   10                  15      


Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro Arg 
            20                  25                  30          


Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp Glu 
        35                  40                  45              


Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly Leu 
    50                  55                  60                  


Met Lys Ile Asp Glu Pro Ser Thr Pro Tyr His Ser Met Met Gly Asp 
65                  70                  75                  80  


Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala Pro 
                85                  90                  95      


Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro Lys 
            100                 105                 110         


Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp Leu 
        115                 120                 125             


Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg Lys 
    130                 135                 140                 


Leu His Tyr Asn Glu 
145                 


<210>  106
<211>  99
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (77)..(77)
<223>  Xaa can be any naturally occurring amino acid

<400>  106

Glu Asp Ser Asn Asn Phe Asp Gly Ser His Val Tyr Met His Ser Asp 
1               5                   10                  15      


Tyr Asn Val Tyr Arg Val Arg Ser Arg Tyr Asn Ser Asp Trp Gly Glu 
            20                  25                  30          


Thr Gly Thr Glu Gln Asp Glu Glu Glu Asp Ser Asp Glu Asn Ser Tyr 
        35                  40                  45              


Tyr Gln Pro Asp Met Glu Tyr Ser Glu Ile Val Gly Leu Pro Glu Glu 
    50                  55                  60                  


Glu Glu Ile Pro Ala Asn Arg Lys Ile Lys Phe Ser Xaa Ala Pro Ile 
65                  70                  75                  80  


Lys Val Phe Asn Thr Tyr Ser Asn Glu Asp Tyr Asp Arg Arg Asn Asp 
                85                  90                  95      


Glu Val Asp 
            


<210>  107
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  107

Met Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu 
1               5                   10                  15      


Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
            20                  25                  30          


Arg Pro Xaa Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
        35                  40                  45              


Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
    50                  55                  60                  


Ala Met Xaa Pro Arg Gln Arg Lys Lys Met Xaa Arg Ile Thr Pro Thr 
65                  70                  75                  80  


Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                85                  90                  95      


Gln Gly Glu Glu 
            100 


<210>  108
<211>  99
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (66)..(66)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<400>  108

Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu Leu 
1               5                   10                  15      


Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Xaa Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro Glu 
        35                  40                  45              


Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu Ala 
    50                  55                  60                  


Met Xaa Pro Arg Gln Arg Lys Lys Met Xaa Arg Ile Thr Pro Thr Met 
65                  70                  75                  80  


Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln Gln 
                85                  90                  95      


Gly Glu Glu 
            


<210>  109
<211>  64
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  109

Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu Leu 
1               5                   10                  15      


Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Xaa Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro Glu 
        35                  40                  45              


Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu Ala 
    50                  55                  60                  


<210>  110
<211>  352
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (72)..(72)
<223>  Xaa can be any naturally occurring amino acid

<400>  110

Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys Gly Ile Leu Lys Asn 
1               5                   10                  15      


Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser Ala Glu Gln Pro Arg 
            20                  25                  30          


Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser Gln Lys Trp Asp Glu 
        35                  40                  45              


Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp Lys Asp Tyr Gly Leu 
    50                  55                  60                  


Met Lys Ile Asp Glu Pro Ser Xaa Pro Tyr His Ser Met Met Gly Asp 
65                  70                  75                  80  


Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu Ala Met Ala Pro 
                85                  90                  95      


Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly Leu Glu Pro Lys 
            100                 105                 110         


Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu Asp Ser Asp Leu 
        115                 120                 125             


Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu Met Lys Arg Lys 
    130                 135                 140                 


Leu His Tyr Asn Glu Ala Ala Ser Thr Ala Ser His Arg Pro Ile Lys 
145                 150                 155                 160 


Gly Ile Leu Lys Asn Lys Thr Ser Thr Thr Ser Ser Met Val Ala Ser 
                165                 170                 175     


Ala Glu Gln Pro Arg Gly Asn Val Asp Glu Glu Leu Ser Lys Lys Ser 
            180                 185                 190         


Gln Lys Trp Asp Glu Met Asn Ile Leu Ala Thr Tyr His Pro Ala Asp 
        195                 200                 205             


Lys Asp Tyr Leu Met Lys Ile Asp Glu Pro Ser Glu Pro Tyr His Ser 
    210                 215                 220                 


Met Met Gly Asp Asp Glu Asp Ala Cys Ser Asp Thr Glu Ala Thr Glu 
225                 230                 235                 240 


Ala Met Ala Pro Asp Ile Leu Ala Arg Lys Leu Ala Ala Ala Glu Gly 
                245                 250                 255     


Leu Glu Pro Lys Tyr Arg Ile Gln Glu Gln Glu Ser Ser Gly Glu Glu 
            260                 265                 270         


Asp Ser Asp Leu Ser Pro Glu Glu Arg Glu Lys Lys Arg Gln Phe Glu 
        275                 280                 285             


Met Lys Arg Lys Leu His Tyr Asn Glu Gly Leu Asn Ile Lys Leu Ala 
    290                 295                 300                 


Arg Gln Leu Ile Ser Lys Asp Leu His Asp Asp Asp Glu Asp Glu Glu 
305                 310                 315                 320 


Met Leu Glu Thr Ala Asp Gly Glu Ser Met Asn Thr Glu Glu Ser Asn 
                325                 330                 335     


Gln Gly Ser Thr Pro Ser Asp Gln Gln Gln Asn Lys Leu Arg Ser Ser 
            340                 345                 350         


<210>  111
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (69)..(69)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (74)..(74)
<223>  Xaa can be any naturally occurring amino acid

<400>  111

Gln Thr Leu Pro Ser Ala Val Lys Gly Asp Glu Lys Met Gly Gly Glu 
1               5                   10                  15      


Asp Asp Glu Leu Lys Gly Leu Leu Gly Leu Pro Glu Glu Glu Xaa Glu 
            20                  25                  30          


Leu Asp Asn Leu Thr Glu Phe Asn Thr Ala His Asn Lys Arg Ile Xaa 
        35                  40                  45              


Thr Leu Thr Ile Glu Glu Gly Asn Leu Asp Ile Gln Arg Pro Lys Arg 
    50                  55                  60                  


Lys Arg Lys Asn Xaa Arg Val Thr Phe Xaa Glu Asp Asp Glu Ile Ile 
65                  70                  75                  80  


Asn Pro Glu Asp Val Asp Pro Ser Val Gly Arg Phe Arg Asn Met Val 
                85                  90                  95      


Gln Thr Ala Val 
            100 


<210>  112
<211>  52
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Ser 
1               5                   10                  15      


Thr Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  113
<211>  66
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  113

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu Pro Pro Ile Asn His Ile Asx Ile Thr Arg Ser Phe 
    50                  55                  60                  


Leu Leu 
65      


<210>  114
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (52)..(52)
<223>  Xaa can be any naturally occurring amino acid

<400>  114

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Xaa 
    50          


<210>  115
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (51)..(51)
<223>  Xaa can be any naturally occurring amino acid

<400>  115

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Xaa Leu 
    50          


<210>  116
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<400>  116

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Xaa Leu Leu 
    50          


<210>  117
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (49)..(49)
<223>  Xaa can be any naturally occurring amino acid

<400>  117

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Xaa Met Leu Leu 
    50          


<210>  118
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa can be any naturally occurring amino acid

<400>  118

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Xaa 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  119
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<400>  119

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Xaa Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  120
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (46)..(46)
<223>  Xaa can be any naturally occurring amino acid

<400>  120

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Xaa Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  121
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (45)..(45)
<223>  Xaa can be any naturally occurring amino acid

<400>  121

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Xaa Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  122
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (44)..(44)
<223>  Xaa can be any naturally occurring amino acid

<400>  122

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Xaa Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  123
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (43)..(43)
<223>  Xaa can be any naturally occurring amino acid

<400>  123

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Xaa Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  124
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (42)..(42)
<223>  Xaa can be any naturally occurring amino acid

<400>  124

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Xaa Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  125
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<400>  125

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Xaa Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  126
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (40)..(40)
<223>  Xaa can be any naturally occurring amino acid

<400>  126

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Xaa Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  127
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (39)..(39)
<223>  Xaa can be any naturally occurring amino acid

<400>  127

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Xaa Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  128
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  128

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Xaa Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  129
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (37)..(37)
<223>  Xaa can be any naturally occurring amino acid

<400>  129

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Cys Xaa Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  130
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (36)..(36)
<223>  Xaa can be any naturally occurring amino acid

<400>  130

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Phe Xaa Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  131
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<400>  131

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Asn Xaa Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  132
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  132

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Ile Xaa Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  133
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (33)..(33)
<223>  Xaa can be any naturally occurring amino acid

<400>  133

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Phe 
            20                  25                  30          


Xaa Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  134
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<400>  134

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Leu Xaa 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  135
<211>  52
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<400>  135

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Xaa Phe 
            20                  25                  30          


Ile Asn Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu 
    50          


<210>  136
<211>  69
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (31)..(31)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  136

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Xaa Phe 
            20                  25                  30          


Ile Xaa Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys Ile Ile 
        35                  40                  45              


Val Met Leu Leu Pro Pro Ile Asn His Ile Asx Ile Thr Arg Ser Met 
    50                  55                  60                  


Asn Met Glu Arg Ser 
65                  


<210>  137
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  137

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Thr Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn 
            20                  25                  30  


<210>  138
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  138

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Ser 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn 
            20                  25                  30  


<210>  139
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  139

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn 
            20                  25                  30  


<210>  140
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  140

Met Asp Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn 
            20                  25                  30  


<210>  141
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  141

Met Glu Lys Val Gln Tyr Ile Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn 
            20                  25                  30  


<210>  142
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  142

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Leu Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn 
            20                  25                  30  


<210>  143
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(16)
<223>  Xaa can be any naturally occurring amino acid

<400>  143

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Thr Ile Glu Met 
            20  


<210>  144
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  144

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Ser 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  145
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  145

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  146
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  146

Met Asp Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  147
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  147

Met Glu Lys Val Gln Tyr Ile Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  148
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  148

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Leu Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  149
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  149

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Gly Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  150
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  150

Met Asp Lys Val Gln Tyr Leu Thr Arg Ser Gly Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  151
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  151

Met Glu Lys Val Gln Tyr Ile Thr Arg Ser Gly Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu Met 
            20  


<210>  152
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  152

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu 
            


<210>  153
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  153

Met Asp Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu 
            


<210>  154
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  154

Met Glu Lys Val Gln Tyr Ile Thr Arg Ser Ala Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu 
            


<210>  155
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  155

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Leu Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu 
            


<210>  156
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (16)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  156

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Gly Ile Arg Arg Ala Xaa 
1               5                   10                  15      


Xaa Ile Glu 
            


<210>  157
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  157

Ser Ala Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Ala Arg 
1               5                   10                  15      


Gln Lys Leu Gln Asn 
            20      


<210>  158
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  158

Ser Gly Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Ala Arg 
1               5                   10                  15      


Gln Lys Leu Gln Asn 
            20      


<210>  159
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  159

Ser Ala Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Gly Arg 
1               5                   10                  15      


Gln Lys Leu Gln Asn 
            20      


<210>  160
<211>  21
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (7)..(8)
<223>  Xaa can be any naturally occurring amino acid

<400>  160

Ser Ala Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Ala Arg 
1               5                   10                  15      


Gln Lys Ile Gln Asn 
            20      


<210>  161
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  161

Ala Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln 
1               5                   10                  15      


Lys Leu Gln 
            


<210>  162
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  162

Gly Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln 
1               5                   10                  15      


Lys Leu Gln 
            


<210>  163
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  163

Ala Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Gly Arg Gln 
1               5                   10                  15      


Lys Leu Gln 
            


<210>  164
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (6)..(7)
<223>  Xaa can be any naturally occurring amino acid

<400>  164

Ala Ile Arg Arg Ala Xaa Xaa Ile Glu Met Pro Gln Gln Ala Arg Gln 
1               5                   10                  15      


Lys Ile Gln 
            


<210>  165
<211>  86
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  165

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Glu 
1               5                   10                  15      


Asp Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Gly Gly 
            20                  25                  30          


Gly Gly Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg 
        35                  40                  45              


Ala Asp Glu Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn 
    50                  55                  60                  


Ala Phe Ile Ala Phe Cys Leu Ile Leu Ile Cys Leu Leu Leu Ile Cys 
65                  70                  75                  80  


Ile Ile Val Met Leu Leu 
                85      


<210>  166
<211>  258
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  166
atggagaagg tgcagtacct gaccaggagc gccatcagga gggccgagga catcgagatg       60

ccccagcagg ccaggcagaa gctccagaac ggcggcggcg gcatggagaa ggtgcagtac      120

ctgaccagga gcgccatcag gagggccgac gagatcgaga tgccccagca ggccaggcag      180

aagctccaga acgccttcat cgccttctgc ctgatcctga tctgcctgct gctgatctgc      240

atcatcgtga tgctgctg                                                    258


<210>  167
<211>  292
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  167
gctagcgccg gcatggagaa ggtgcagtac ctgaccagga gcgccatcag gagggccgag       60

gacatcgaga tgccccagca ggccaggcag aagctccaga acggcggcgg cggcatggag      120

aaggtgcagt acctgaccag gagcgccatc aggagggccg acgagatcga gatgccccag      180

caggccaggc agaagctcca gaacgccttc atcgccttct gcctgatcct gatctgcctg      240

ctgctgatct gcatcatcgt gatgctgctg cccgggggag gcggaatcga tt              292


<210>  168
<211>  301
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  168
gctagcgcca ccatggccgg catggagaag gtgcagtacc tgaccaggag cgccatcagg       60

agggccgagg acatcgagat gccccagcag gccaggcaga agctccagaa cggcggcggc      120

ggcatggaga aggtgcagta cctgaccagg agcgccatca ggagggccga cgagatcgag      180

atgccccagc aggccaggca gaagctccag aacgccttca tcgccttctg cctgatcctg      240

atctgcctgc tgctgatctg catcatcgtg atgctgctgc ccgggggagg cggaatcgat      300

t                                                                      301


<210>  169
<211>  75
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  169

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Asp 
1               5                   10                  15      


Glu Ile Glu Gly Gly Gly Gly Met Glu Lys Val Gln Tyr Leu Thr Arg 
            20                  25                  30          


Ser Ala Ile Arg Arg Ala Asp Glu Ile Glu Met Pro Gln Gln Ala Arg 
        35                  40                  45              


Gln Lys Leu Gln Asn Ala Phe Ile Ala Phe Cys Leu Ile Leu Ile Cys 
    50                  55                  60                  


Leu Leu Leu Ile Cys Ile Ile Val Met Leu Leu 
65                  70                  75  


<210>  170
<211>  225
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  170
atggagaagg tgcagtacct gaccaggagc gccatcagga gggccgacga gatcgagggc       60

ggcggcggca tggagaaggt gcagtacctg accaggagcg ccatcaggag ggccgacgag      120

atcgagatgc cccagcaggc caggcagaag ctccagaacg ccttcatcgc cttctgcctg      180

atcctgatct gcctgctgct gatctgcatc atcgtgatgc tgctg                      225


<210>  171
<211>  259
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  171
gctagcgccg gcatggagaa ggtgcagtac ctgaccagga gcgccatcag gagggccgac       60

gagatcgagg gcggcggcgg catggagaag gtgcagtacc tgaccaggag cgccatcagg      120

agggccgacg agatcgagat gccccagcag gccaggcaga agctccagaa cgccttcatc      180

gccttctgcc tgatcctgat ctgcctgctg ctgatctgca tcatcgtgat gctgctgccc      240

gggggaggcg gaatcgatt                                                   259


<210>  172
<211>  268
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  172
gctagcgcca ccatggccgg catggagaag gtgcagtacc tgaccaggag cgccatcagg       60

agggccgacg agatcgaggg cggcggcggc atggagaagg tgcagtacct gaccaggagc      120

gccatcagga gggccgacga gatcgagatg ccccagcagg ccaggcagaa gctccagaac      180

gccttcatcg ccttctgcct gatcctgatc tgcctgctgc tgatctgcat catcgtgatg      240

ctgctgcccg ggggaggcgg aatcgatt                                         268


<210>  173
<211>  91
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  173

Met Glu Lys Val Gln Tyr Leu Thr Arg Ser Ala Ile Arg Arg Ala Asp 
1               5                   10                  15      


Glu Ile Glu Met Gly Gly Gly Gly Ser Ala Ile Arg Arg Ala Asp Glu 
            20                  25                  30          


Ile Glu Met Pro Gln Gln Ala Arg Gln Lys Leu Gln Asn Gly Gly Gly 
        35                  40                  45              


Gly Ala Ile Arg Arg Ala Glu Asp Ile Glu Met Pro Gln Gln Ala Arg 
    50                  55                  60                  


Gln Lys Leu Gln Gly Gly Gly Gly Ala Ile Arg Arg Ala Asp Glu Ile 
65                  70                  75                  80  


Glu Met Pro Gln Gln Ala Arg Gln Lys Ile Gln 
                85                  90      


<210>  174
<211>  273
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  174
atggagaagg tgcagtacct gaccaggagc gccatcagga gggccgacga gatcgagatg       60

ggcggcggcg gcagcgccat caggagggcc gacgagatcg agatgcccca gcaggccagg      120

cagaagctcc agaacggcgg cggcggcgcc atcaggaggg ccgaggacat cgagatgccc      180

cagcaggcca ggcagaagct ccagggcggc ggcggcgcca tcaggagggc cgacgagatc      240

gagatgcccc agcaggccag gcagaagatc cag                                   273


<210>  175
<211>  307
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  175
gctagcgccg gcatggagaa ggtgcagtac ctgaccagga gcgccatcag gagggccgac       60

gagatcgaga tgggcggcgg cggcagcgcc atcaggaggg ccgacgagat cgagatgccc      120

cagcaggcca ggcagaagct ccagaacggc ggcggcggcg ccatcaggag ggccgaggac      180

atcgagatgc cccagcaggc caggcagaag ctccagggcg gcggcggcgc catcaggagg      240

gccgacgaga tcgagatgcc ccagcaggcc aggcagaaga tccagcccgg gggaggcgga      300

atcgatt                                                                307


<210>  176
<211>  316
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  176
gctagcgcca ccatggccgg catggagaag gtgcagtacc tgaccaggag cgccatcagg       60

agggccgacg agatcgagat gggcggcggc ggcagcgcca tcaggagggc cgacgagatc      120

gagatgcccc agcaggccag gcagaagctc cagaacggcg gcggcggcgc catcaggagg      180

gccgaggaca tcgagatgcc ccagcaggcc aggcagaagc tccagggcgg cggcggcgcc      240

atcaggaggg ccgacgagat cgagatgccc cagcaggcca ggcagaagat ccagcccggg      300

ggaggcggaa tcgatt                                                      316


<210>  177
<211>  73
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  177

Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn Pro Tyr Arg 
1               5                   10                  15      


Ile Pro Pro Leu Phe Pro Ile Lys Asp Phe Val Lys Thr Lys Cys Lys 
            20                  25                  30          


Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ala Val Leu Leu Pro 
        35                  40                  45              


Lys Lys Thr Ser Ala Thr Val Gly Pro Lys Ala Pro Ser Gly Gly Lys 
    50                  55                  60                  


Lys Ala Thr Gln Ala Asp Gln Glu Tyr 
65                  70              


<210>  178
<211>  219
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  178
ggcctgatca cccccaacaa gcacggcctc ctgcagaacc cctacaggat tccccccctg       60

ttccccatca aggacttcgt gaagaccaag tgcaagaaga acctcctgga ggagaacttc      120

gaggagcacg ccgtcctgct gcccaagaag accagcgcca ccgtgggccc caaggccccc      180

agcggcggca agaaggccac ccaagccgac caggagtac                             219


<210>  179
<211>  253
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  179
gctagcgccg gcggcctgat cacccccaac aagcacggcc tcctgcagaa cccctacagg       60

attccccccc tgttccccat caaggacttc gtgaagacca agtgcaagaa gaacctcctg      120

gaggagaact tcgaggagca cgccgtcctg ctgcccaaga agaccagcgc caccgtgggc      180

cccaaggccc ccagcggcgg caagaaggcc acccaagccg accaggagta ccccggggga      240

ggcggaatcg att                                                         253


<210>  180
<211>  262
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  180
gctagcgcca ccatggccgg cggcctgatc acccccaaca agcacggcct cctgcagaac       60

ccctacagga ttccccccct gttccccatc aaggacttcg tgaagaccaa gtgcaagaag      120

aacctcctgg aggagaactt cgaggagcac gccgtcctgc tgcccaagaa gaccagcgcc      180

accgtgggcc ccaaggcccc cagcggcggc aagaaggcca cccaagccga ccaggagtac      240

cccgggggag gcggaatcga tt                                               262


<210>  181
<211>  74
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  181

Ala Val Glu Ile Arg Ser Arg His Ser Glu Tyr Pro Ala Gly Thr Glu 
1               5                   10                  15      


Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser 
            20                  25                  30          


Arg Glu Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Ala Val Leu Leu 
        35                  40                  45              


Pro Lys Lys Thr Ser Ala Thr Val Gly Pro Lys Ala Pro Ser Gly Gly 
    50                  55                  60                  


Lys Lys Ala Thr Gln Ala Asp Gln Glu Tyr 
65                  70                  


<210>  182
<211>  222
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  182
gccgtggaga tcaggagcag gcacagcgag taccccgccg gaaccgagga cgacgagggc       60

atgggcgagg agcccagccc cttcaggggc aggagcaggg aggccccccc caacctgtgg      120

gccgcccaga gagccgtgct gctgcccaag aagaccagcg ccaccgtggg ccccaaggcc      180

cccagcggcg gcaagaaggc cacccaagcc gaccaggagt ac                         222


<210>  183
<211>  256
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  183
gctagcgccg gcgccgtgga gatcaggagc aggcacagcg agtaccccgc cggaaccgag       60

gacgacgagg gcatgggcga ggagcccagc cccttcaggg gcaggagcag ggaggccccc      120

cccaacctgt gggccgccca gagagccgtg ctgctgccca agaagaccag cgccaccgtg      180

ggccccaagg cccccagcgg cggcaagaag gccacccaag ccgaccagga gtaccccggg      240

ggaggcggaa tcgatt                                                      256


<210>  184
<211>  265
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  184
gctagcgcca ccatggccgg cgccgtggag atcaggagca ggcacagcga gtaccccgcc       60

ggaaccgagg acgacgaggg catgggcgag gagcccagcc ccttcagggg caggagcagg      120

gaggcccccc ccaacctgtg ggccgcccag agagccgtgc tgctgcccaa gaagaccagc      180

gccaccgtgg gccccaaggc ccccagcggc ggcaagaagg ccacccaagc cgaccaggag      240

taccccgggg gaggcggaat cgatt                                            265


<210>  185
<211>  71
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  185

Glu Ser Glu Arg Ser Val Asp Pro Glu Glu Leu Asp Glu Arg Ala Gly 
1               5                   10                  15      


Ser Pro Gln Leu Asp Asp Ile Arg Val Phe Gln Asn Glu Val Leu Gly 
            20                  25                  30          


Val Gln Lys Thr Ala Met Asn Trp Arg Leu Ser Ala Arg Asn Ala Ala 
        35                  40                  45              


Arg Arg Asp Glu Val Leu Ala Ala Ser Arg Asp Tyr Arg Asn Ile Ile 
    50                  55                  60                  


Glu Arg Leu Gln Asp Ile Val 
65                  70      


<210>  186
<211>  213
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  186
gagagcgaga ggagcgtgga ccccgaggag ctggacgaga gggccggaag cccccagctg       60

gacgacatca gggtgttcca gaacgaggtg ctgggcgtgc agaagaccgc catgaactgg      120

aggctgtccg ccaggaacgc cgccaggagg gacgaggtgc tggccgccag cagggactac      180

aggaacatca tcgagaggct gcaggacatc gtg                                   213


<210>  187
<211>  247
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  187
gctagcgccg gcgagagcga gaggagcgtg gaccccgagg agctggacga gagggccgga       60

agcccccagc tggacgacat cagggtgttc cagaacgagg tgctgggcgt gcagaagacc      120

gccatgaact ggaggctgtc cgccaggaac gccgccagga gggacgaggt gctggccgcc      180

agcagggact acaggaacat catcgagagg ctgcaggaca tcgtgcccgg gggaggcgga      240

atcgatt                                                                247


<210>  188
<211>  256
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  188
gctagcgcca ccatggccgg cgagagcgag aggagcgtgg accccgagga gctggacgag       60

agggccggaa gcccccagct ggacgacatc agggtgttcc agaacgaggt gctgggcgtg      120

cagaagaccg ccatgaactg gaggctgtcc gccaggaacg ccgccaggag ggacgaggtg      180

ctggccgcca gcagggacta caggaacatc atcgagaggc tgcaggacat cgtgcccggg      240

ggaggcggaa tcgatt                                                      256


<210>  189
<211>  74
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  189

Lys Ile Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg 
1               5                   10                  15      


Thr Asp Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu 
            20                  25                  30          


Gly Arg Met His Asp Glu Lys Val Ala Lys Gln Lys Arg Asn Glu Gln 
        35                  40                  45              


Leu Lys Arg Trp Ile Gly Asp Glu Thr Asp Leu Glu Pro Pro Val Val 
    50                  55                  60                  


Lys Arg Gln Lys Thr Lys Val Lys Phe Asp 
65                  70                  


<210>  190
<211>  222
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  190
aagatcgccg acttcggctg gagcgtccac gcccccagca gcaggaggac cgacctgtgc       60

ggcaccctgg actacctccc ccccgagatg atcgagggca ggatgcacga cgagaaggtg      120

gccaagcaga aaaggaacga gcagctgaaa aggtggatcg gcgacgagac cgacctggag      180

ccccccgtgg tgaaaaggca gaagaccaag gtgaagttcg ac                         222


<210>  191
<211>  256
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  191
gctagcgccg gcaagatcgc cgacttcggc tggagcgtcc acgcccccag cagcaggagg       60

accgacctgt gcggcaccct ggactacctc ccccccgaga tgatcgaggg caggatgcac      120

gacgagaagg tggccaagca gaaaaggaac gagcagctga aaaggtggat cggcgacgag      180

accgacctgg agccccccgt ggtgaaaagg cagaagacca aggtgaagtt cgaccccggg      240

ggaggcggaa tcgatt                                                      256


<210>  192
<211>  265
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  192
gctagcgcca ccatggccgg caagatcgcc gacttcggct ggagcgtcca cgcccccagc       60

agcaggagga ccgacctgtg cggcaccctg gactacctcc cccccgagat gatcgagggc      120

aggatgcacg acgagaaggt ggccaagcag aaaaggaacg agcagctgaa aaggtggatc      180

ggcgacgaga ccgacctgga gccccccgtg gtgaaaaggc agaagaccaa ggtgaagttc      240

gaccccgggg gaggcggaat cgatt                                            265


<210>  193
<211>  116
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  193

Ile Gln Phe Thr Val Pro Leu Leu Glu Pro His Leu Asp Pro Glu Ala 
1               5                   10                  15      


Ala Glu Gln Ile Arg Arg Arg Arg Pro Ala Pro Ala Thr Leu Val Leu 
            20                  25                  30          


Thr Ser Asp Gln Ser Ser Pro Glu Ile Asp Glu Asp Arg Ile Pro Asn 
        35                  40                  45              


Pro His Leu Gly Glu Thr Gly Thr Glu Gln Asp Glu Glu Glu Asp Ser 
    50                  55                  60                  


Asp Glu Asn Ser Tyr Tyr Gln Pro Asp Met Glu Tyr Ser Glu Ile Val 
65                  70                  75                  80  


Gly Leu Pro Glu Glu Glu Glu Ile Pro Ala Asn Arg Lys Ile Lys Phe 
                85                  90                  95      


Ser Ala Ala Pro Ile Lys Val Phe Asn Thr Tyr Ser Asn Glu Asp Tyr 
            100                 105                 110         


Asp Arg Arg Asn 
        115     


<210>  194
<211>  348
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  194
atccagttca ccgtgcccct gctggagccc cacctggacc ccgaggccgc cgagcagatc       60

aggaggagga ggcccgcccc cgccaccctg gtgctgacca gcgaccagag cagccccgag      120

atcgacgagg acaggattcc caacccccac ctgggcgaga ccggcaccga gcaggacgag      180

gaggaggaca gcgacgagaa cagctactac cagcccgaca tggagtacag cgagatcgtg      240

ggcctgcccg aggaggagga gatccccgcc aacaggaaga tcaagttcag cgccgccccc      300

atcaaggtgt tcaacaccta cagcaacgag gactacgaca ggaggaac                   348


<210>  195
<211>  382
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  195
gctagcgccg gcatccagtt caccgtgccc ctgctggagc cccacctgga ccccgaggcc       60

gccgagcaga tcaggaggag gaggcccgcc cccgccaccc tggtgctgac cagcgaccag      120

agcagccccg agatcgacga ggacaggatt cccaaccccc acctgggcga gaccggcacc      180

gagcaggacg aggaggagga cagcgacgag aacagctact accagcccga catggagtac      240

agcgagatcg tgggcctgcc cgaggaggag gagatccccg ccaacaggaa gatcaagttc      300

agcgccgccc ccatcaaggt gttcaacacc tacagcaacg aggactacga caggaggaac      360

cccgggggag gcggaatcga tt                                               382


<210>  196
<211>  391
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  196
gctagcgcca ccatggccgg catccagttc accgtgcccc tgctggagcc ccacctggac       60

cccgaggccg ccgagcagat caggaggagg aggcccgccc ccgccaccct ggtgctgacc      120

agcgaccaga gcagccccga gatcgacgag gacaggattc ccaaccccca cctgggcgag      180

accggcaccg agcaggacga ggaggaggac agcgacgaga acagctacta ccagcccgac      240

atggagtaca gcgagatcgt gggcctgccc gaggaggagg agatccccgc caacaggaag      300

atcaagttca gcgccgcccc catcaaggtg ttcaacacct acagcaacga ggactacgac      360

aggaggaacc ccgggggagg cggaatcgat t                                     391


<210>  197
<211>  123
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  197

Gly Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val 
1               5                   10                  15      


Thr Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu 
            20                  25                  30          


Asp Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu 
        35                  40                  45              


Ala Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala 
    50                  55                  60                  


Arg Arg Leu Arg Asp Arg Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val 
65                  70                  75                  80  


Glu Val Ala Lys Ala Gln Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp 
                85                  90                  95      


Thr Arg Leu Ser Ala Ala Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn 
            100                 105                 110         


Glu Tyr Lys Ser Asn Glu Met Glu Val His Ala 
        115                 120             


<210>  198
<211>  369
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  198
ggcgacccca accagctgac caggaagggc aggaaaagga aaagcgtgac ctggcccgag       60

gagggcaagc tgagggagta cttctacttc gagctggacg agaccgagag ggtgaacgtg      120

aacaagatca aggacttcgg cgaggccgcc aagagggaga tcctgagcga caggcacgcc      180

ttcgagaccg ccaggaggct gagggacagg aagatcctga tcaggttcag cgactacgtg      240

gaggtggcca aggcccagga ctacgacagg agggccgaca agccctggac caggctgtcc      300

gccgccgaca aagccgccat caggaaggag ctgaacgagt acaagagcaa cgagatggag      360

gtccacgcc                                                              369


<210>  199
<211>  403
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  199
gctagcgccg gcggcgaccc caaccagctg accaggaagg gcaggaaaag gaaaagcgtg       60

acctggcccg aggagggcaa gctgagggag tacttctact tcgagctgga cgagaccgag      120

agggtgaacg tgaacaagat caaggacttc ggcgaggccg ccaagaggga gatcctgagc      180

gacaggcacg ccttcgagac cgccaggagg ctgagggaca ggaagatcct gatcaggttc      240

agcgactacg tggaggtggc caaggcccag gactacgaca ggagggccga caagccctgg      300

accaggctgt ccgccgccga caaagccgcc atcaggaagg agctgaacga gtacaagagc      360

aacgagatgg aggtccacgc ccccggggga ggcggaatcg att                        403


<210>  200
<211>  412
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  200
gctagcgcca ccatggccgg cggcgacccc aaccagctga ccaggaaggg caggaaaagg       60

aaaagcgtga cctggcccga ggagggcaag ctgagggagt acttctactt cgagctggac      120

gagaccgaga gggtgaacgt gaacaagatc aaggacttcg gcgaggccgc caagagggag      180

atcctgagcg acaggcacgc cttcgagacc gccaggaggc tgagggacag gaagatcctg      240

atcaggttca gcgactacgt ggaggtggcc aaggcccagg actacgacag gagggccgac      300

aagccctgga ccaggctgtc cgccgccgac aaagccgcca tcaggaagga gctgaacgag      360

tacaagagca acgagatgga ggtccacgcc cccgggggag gcggaatcga tt              412


<210>  201
<211>  403
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (288)..(288)
<223>  Xaa can be any naturally occurring amino acid

<400>  201

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Xaa 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  202
<211>  1030
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  202

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
1               5                   10                  15      


Trp Ile Gly Xaa Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
            20                  25                  30          


Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
        35                  40                  45              


Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
    50                  55                  60                  


Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
65                  70                  75                  80  


Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                85                  90                  95      


Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
            100                 105                 110         


Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
        115                 120                 125             


Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
    130                 135                 140                 


Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
145                 150                 155                 160 


Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                165                 170                 175     


Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
            180                 185                 190         


Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
        195                 200                 205             


Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
    210                 215                 220                 


Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
225                 230                 235                 240 


His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                245                 250                 255     


Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
            260                 265                 270         


Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
        275                 280                 285             


Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
    290                 295                 300                 


Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
305                 310                 315                 320 


Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                325                 330                 335     


Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
            340                 345                 350         


Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
        355                 360                 365             


Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
    370                 375                 380                 


Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                405                 410                 415     


Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
            420                 425                 430         


Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
        435                 440                 445             


Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
    450                 455                 460                 


Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
465                 470                 475                 480 


Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                485                 490                 495     


Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
            500                 505                 510         


Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
        515                 520                 525             


Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
    530                 535                 540                 


Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
545                 550                 555                 560 


Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                565                 570                 575     


Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
            580                 585                 590         


Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
        595                 600                 605             


Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
    610                 615                 620                 


Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
625                 630                 635                 640 


Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                645                 650                 655     


Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
            660                 665                 670         


Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
        675                 680                 685             


Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
    690                 695                 700                 


Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
705                 710                 715                 720 


Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                725                 730                 735     


Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
            740                 745                 750         


Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
        755                 760                 765             


Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
    770                 775                 780                 


Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
785                 790                 795                 800 


Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                805                 810                 815     


Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
            820                 825                 830         


Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
        835                 840                 845             


Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
    850                 855                 860                 


Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
865                 870                 875                 880 


Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                885                 890                 895     


Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
            900                 905                 910         


Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
        915                 920                 925             


Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
    930                 935                 940                 


Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                965                 970                 975     


Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
            980                 985                 990         


Arg Ile Ser Glu Met Glu Glu Glu  Leu Lys Met Leu Pro  Asp Leu Lys 
        995                 1000                 1005             


Ala Asp  Asn Gln Arg Leu Lys  Asp Glu Asn Gly Ala  Leu Ile Arg 
    1010                 1015                 1020             


Val Ile  Ser Lys Leu Ser Lys  
    1025                 1030 


<210>  203
<211>  168
<212>  PRT
<213>  mouse


<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (99)..(99)
<223>  Xaa can be any naturally occurring amino acid

<400>  203

Met Phe Gln Ile Pro Glu Phe Glu Pro Ser Glu Gln Glu Asp Ser Ser 
1               5                   10                  15      


Ser Ala Glu Arg Gly Leu Gly Pro Ser Pro Ala Gly Asp Gly Pro Ser 
            20                  25                  30          


Gly Ser Gly Lys His His Arg Gln Ala Pro Gly Leu Leu Trp Asp Ala 
        35                  40                  45              


Ser His Gln Gln Glu Gln Pro Thr Ser Ser Ser His His Gly Gly Ala 
    50                  55                  60                  


Gly Ala Val Glu Ile Arg Ser Arg His Ser Xaa Tyr Pro Ala Gly Thr 
65                  70                  75                  80  


Glu Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg 
                85                  90                  95      


Ser Arg Xaa Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg Tyr Gly Arg 
            100                 105                 110         


Glu Leu Arg Arg Met Ser Asp Glu Phe Val Asp Ser Phe Lys Lys Gly 
        115                 120                 125             


Leu Pro Arg Pro Lys Ser Ala Gly Thr Ala Thr Gln Met Arg Gln Ser 
    130                 135                 140                 


Ser Ser Trp Thr Arg Val Phe Gln Ser Trp Trp Asp Arg Asn Leu Gly 
145                 150                 155                 160 


Arg Gly Ser Ser Ala Pro Ser Gln 
                165             


<210>  204
<211>  1863
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (988)..(988)
<223>  Xaa can be any naturally occurring amino acid

<400>  204

Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 
1               5                   10                  15      


Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 
            20                  25                  30          


Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 
        35                  40                  45              


Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 
    50                  55                  60                  


Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 
65                  70                  75                  80  


Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 
                85                  90                  95      


Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 
            100                 105                 110         


Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 
        115                 120                 125             


Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 
    130                 135                 140                 


Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 
145                 150                 155                 160 


Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 
                165                 170                 175     


Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 
            180                 185                 190         


Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 
        195                 200                 205             


Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 
    210                 215                 220                 


Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 
225                 230                 235                 240 


Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 
                245                 250                 255     


His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 
            260                 265                 270         


Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 
        275                 280                 285             


Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 
    290                 295                 300                 


Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 
305                 310                 315                 320 


Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 
                325                 330                 335     


Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 
            340                 345                 350         


Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 
        355                 360                 365             


Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 
    370                 375                 380                 


Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 
385                 390                 395                 400 


Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 
                405                 410                 415     


Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 
            420                 425                 430         


Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 
        435                 440                 445             


Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 
    450                 455                 460                 


Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 
465                 470                 475                 480 


Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 
                485                 490                 495     


Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 
            500                 505                 510         


His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 
        515                 520                 525             


Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 
    530                 535                 540                 


Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 
545                 550                 555                 560 


Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 
                565                 570                 575     


Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 
            580                 585                 590         


Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 
        595                 600                 605             


Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 
    610                 615                 620                 


Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 
625                 630                 635                 640 


Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 
                645                 650                 655     


Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 
            660                 665                 670         


Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 
        675                 680                 685             


Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 
    690                 695                 700                 


Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 
705                 710                 715                 720 


Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 
                725                 730                 735     


Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 
            740                 745                 750         


Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 
        755                 760                 765             


Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 
    770                 775                 780                 


Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 
785                 790                 795                 800 


Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 
                805                 810                 815     


Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 
            820                 825                 830         


Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 
        835                 840                 845             


Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 
    850                 855                 860                 


Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 
865                 870                 875                 880 


Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 
                885                 890                 895     


Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 
            900                 905                 910         


Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 
        915                 920                 925             


Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 
    930                 935                 940                 


Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 
945                 950                 955                 960 


Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 
                965                 970                 975     


Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Xaa Phe Val Lys Thr 
            980                 985                 990         


Lys Cys Lys Lys Asn Leu Leu Glu  Glu Asn Phe Glu Glu  His Ser Met 
        995                 1000                 1005             


Ser Pro  Glu Arg Glu Met Gly  Asn Glu Asn Ile Pro  Ser Thr Val 
    1010                 1015                 1020             


Ser Thr  Ile Ser Arg Asn Asn  Ile Arg Glu Asn Val  Phe Lys Glu 
    1025                 1030                 1035             


Ala Ser  Ser Ser Asn Ile Asn  Glu Val Gly Ser Ser  Thr Asn Glu 
    1040                 1045                 1050             


Val Gly  Ser Ser Ile Asn Glu  Ile Gly Ser Ser Asp  Glu Asn Ile 
    1055                 1060                 1065             


Gln Ala  Glu Leu Gly Arg Asn  Arg Gly Pro Lys Leu  Asn Ala Met 
    1070                 1075                 1080             


Leu Arg  Leu Gly Val Leu Gln  Pro Glu Val Tyr Lys  Gln Ser Leu 
    1085                 1090                 1095             


Pro Gly  Ser Asn Cys Lys His  Pro Glu Ile Lys Lys  Gln Glu Tyr 
    1100                 1105                 1110             


Glu Glu  Val Val Gln Thr Val  Asn Thr Asp Phe Ser  Pro Tyr Leu 
    1115                 1120                 1125             


Ile Ser  Asp Asn Leu Glu Gln  Pro Met Gly Ser Ser  His Ala Ser 
    1130                 1135                 1140             


Gln Val  Cys Ser Glu Thr Pro  Asp Asp Leu Leu Asp  Asp Gly Glu 
    1145                 1150                 1155             


Ile Lys  Glu Asp Thr Ser Phe  Ala Glu Asn Asp Ile  Lys Glu Ser 
    1160                 1165                 1170             


Ser Ala  Val Phe Ser Lys Ser  Val Gln Lys Gly Glu  Leu Ser Arg 
    1175                 1180                 1185             


Ser Pro  Ser Pro Phe Thr His  Thr His Leu Ala Gln  Gly Tyr Arg 
    1190                 1195                 1200             


Arg Gly  Ala Lys Lys Leu Glu  Ser Ser Glu Glu Asn  Leu Ser Ser 
    1205                 1210                 1215             


Glu Asp  Glu Glu Leu Pro Cys  Phe Gln His Leu Leu  Phe Gly Lys 
    1220                 1225                 1230             


Val Asn  Asn Ile Pro Ser Gln  Ser Thr Arg His Ser  Thr Val Ala 
    1235                 1240                 1245             


Thr Glu  Cys Leu Ser Lys Asn  Thr Glu Glu Asn Leu  Leu Ser Leu 
    1250                 1255                 1260             


Lys Asn  Ser Leu Asn Asp Cys  Ser Asn Gln Val Ile  Leu Ala Lys 
    1265                 1270                 1275             


Ala Ser  Gln Glu His His Leu  Ser Glu Glu Thr Lys  Cys Ser Ala 
    1280                 1285                 1290             


Ser Leu  Phe Ser Ser Gln Cys  Ser Glu Leu Glu Asp  Leu Thr Ala 
    1295                 1300                 1305             


Asn Thr  Asn Thr Gln Asp Pro  Phe Leu Ile Gly Ser  Ser Lys Gln 
    1310                 1315                 1320             


Met Arg  His Gln Ser Glu Ser  Gln Gly Val Gly Leu  Ser Asp Lys 
    1325                 1330                 1335             


Glu Leu  Val Ser Asp Asp Glu  Glu Arg Gly Thr Gly  Leu Glu Glu 
    1340                 1345                 1350             


Asn Asn  Gln Glu Glu Gln Ser  Met Asp Ser Asn Leu  Gly Glu Ala 
    1355                 1360                 1365             


Ala Ser  Gly Cys Glu Ser Glu  Thr Ser Val Ser Glu  Asp Cys Ser 
    1370                 1375                 1380             


Gly Leu  Ser Ser Gln Ser Asp  Ile Leu Thr Thr Gln  Gln Arg Asp 
    1385                 1390                 1395             


Thr Met  Gln His Asn Leu Ile  Lys Leu Gln Gln Glu  Met Ala Glu 
    1400                 1405                 1410             


Leu Glu  Ala Val Leu Glu Gln  His Gly Ser Gln Pro  Ser Asn Ser 
    1415                 1420                 1425             


Tyr Pro  Ser Ile Ile Ser Asp  Ser Ser Ala Leu Glu  Asp Leu Arg 
    1430                 1435                 1440             


Asn Pro  Glu Gln Ser Thr Ser  Glu Lys Ala Val Leu  Thr Ser Gln 
    1445                 1450                 1455             


Lys Ser  Ser Glu Tyr Pro Ile  Ser Gln Asn Pro Glu  Gly Leu Ser 
    1460                 1465                 1470             


Ala Asp  Lys Phe Glu Val Ser  Ala Asp Ser Ser Thr  Ser Lys Asn 
    1475                 1480                 1485             


Lys Glu  Pro Gly Val Glu Arg  Ser Ser Pro Ser Lys  Cys Pro Ser 
    1490                 1495                 1500             


Leu Asp  Asp Arg Trp Tyr Met  His Ser Cys Ser Gly  Ser Leu Gln 
    1505                 1510                 1515             


Asn Arg  Asn Tyr Pro Ser Gln  Glu Glu Leu Ile Lys  Val Val Asp 
    1520                 1525                 1530             


Val Glu  Glu Gln Gln Leu Glu  Glu Ser Gly Pro His  Asp Leu Thr 
    1535                 1540                 1545             


Glu Thr  Ser Tyr Leu Pro Arg  Gln Asp Leu Glu Gly  Thr Pro Tyr 
    1550                 1555                 1560             


Leu Glu  Ser Gly Ile Ser Leu  Phe Ser Asp Asp Pro  Glu Ser Asp 
    1565                 1570                 1575             


Pro Ser  Glu Asp Arg Ala Pro  Glu Ser Ala Arg Val  Gly Asn Ile 
    1580                 1585                 1590             


Pro Ser  Ser Thr Ser Ala Leu  Lys Val Pro Gln Leu  Lys Val Ala 
    1595                 1600                 1605             


Glu Ser  Ala Gln Ser Pro Ala  Ala Ala His Thr Thr  Asp Thr Ala 
    1610                 1615                 1620             


Gly Tyr  Asn Ala Met Glu Glu  Ser Val Ser Arg Glu  Lys Pro Glu 
    1625                 1630                 1635             


Leu Thr  Ala Ser Thr Glu Arg  Val Asn Lys Arg Met  Ser Met Val 
    1640                 1645                 1650             


Val Ser  Gly Leu Thr Pro Glu  Glu Phe Met Leu Val  Tyr Lys Phe 
    1655                 1660                 1665             


Ala Arg  Lys His His Ile Thr  Leu Thr Asn Leu Ile  Thr Glu Glu 
    1670                 1675                 1680             


Thr Thr  His Val Val Met Lys  Thr Asp Ala Glu Phe  Val Cys Glu 
    1685                 1690                 1695             


Arg Thr  Leu Lys Tyr Phe Leu  Gly Ile Ala Gly Gly  Lys Trp Val 
    1700                 1705                 1710             


Val Ser  Tyr Phe Trp Val Thr  Gln Ser Ile Lys Glu  Arg Lys Met 
    1715                 1720                 1725             


Leu Asn  Glu His Asp Phe Glu  Val Arg Gly Asp Val  Val Asn Gly 
    1730                 1735                 1740             


Arg Asn  His Gln Gly Pro Lys  Arg Ala Arg Glu Ser  Gln Asp Arg 
    1745                 1750                 1755             


Lys Ile  Phe Arg Gly Leu Glu  Ile Cys Cys Tyr Gly  Pro Phe Thr 
    1760                 1765                 1770             


Asn Met  Pro Thr Asp Gln Leu  Glu Trp Met Val Gln  Leu Cys Gly 
    1775                 1780                 1785             


Ala Ser  Val Val Lys Glu Leu  Ser Ser Phe Thr Leu  Gly Thr Gly 
    1790                 1795                 1800             


Val His  Pro Ile Val Val Val  Gln Pro Asp Ala Trp  Thr Glu Asp 
    1805                 1810                 1815             


Asn Gly  Phe His Ala Ile Gly  Gln Met Cys Glu Ala  Pro Val Val 
    1820                 1825                 1830             


Thr Arg  Glu Trp Val Leu Asp  Ser Val Ala Leu Tyr  Gln Cys Gln 
    1835                 1840                 1845             


Glu Leu  Asp Thr Tyr Leu Ile  Pro Gln Ile Pro His  Ser His Tyr 
    1850                 1855                 1860             


<210>  205
<211>  716
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (535)..(535)
<223>  Xaa can be any naturally occurring amino acid

<400>  205

Met Ala Ala Thr Ala Ala Val Pro Ser Ala Val Gly Gly Arg Ala Asn 
1               5                   10                  15      


Lys Arg Gly Gly Gly Ser Gly Gly Gly Gly Thr Gln Gly Ala Glu Glu 
            20                  25                  30          


Glu Pro Pro Pro Pro Leu Gln Ala Val Leu Val Ala Asp Ser Phe Asp 
        35                  40                  45              


Arg Arg Phe Phe Pro Ile Ser Lys Asp Gln Pro Arg Val Leu Leu Pro 
    50                  55                  60                  


Leu Ala Asn Val Ala Leu Ile Asp Tyr Thr Leu Glu Phe Leu Thr Ala 
65                  70                  75                  80  


Thr Gly Val Gln Glu Thr Phe Val Phe Cys Cys Trp Lys Ala Ala Gln 
                85                  90                  95      


Ile Lys Glu His Leu Gln Lys Ser Lys Trp Cys His Pro Thr Ser Leu 
            100                 105                 110         


Asn Val Val Arg Ile Thr Thr Ser Asp Leu Tyr Arg Ser Leu Gly Asp 
        115                 120                 125             


Val Leu Arg Asp Val Asp Ala Lys Ala Leu Val Arg Ser Asp Phe Leu 
    130                 135                 140                 


Leu Ile Tyr Gly Asp Val Val Ser Asn Ile Asn Ile Ser Lys Ala Leu 
145                 150                 155                 160 


Glu Glu His Arg Leu Arg Arg Lys Leu Glu Lys Asn Val Ser Val Met 
                165                 170                 175     


Thr Met Val Phe Lys Glu Ser Ser Pro Ser His Pro Thr Arg Cys His 
            180                 185                 190         


Glu Asp Asn Val Val Leu Ala Val Asp Ser Thr Thr Asn Arg Ile Leu 
        195                 200                 205             


His Phe Gln Lys Thr Gln Gly Leu Arg His Phe Ser Phe Pro Leu Gly 
    210                 215                 220                 


Leu Phe Gln Gly Ser Leu Asp Gly Val Glu Ile Arg Tyr Asp Leu Leu 
225                 230                 235                 240 


Asp Cys His Ile Ser Ile Cys Ser Pro Gln Val Ala Gln Leu Phe Thr 
                245                 250                 255     


Asp Asn Phe Asp Tyr Gln Thr Arg Asp Asp Phe Val Arg Gly Leu Leu 
            260                 265                 270         


Val Asn Glu Glu Ile Leu Gly Asn Gln Ile His Leu His Val Thr Ser 
        275                 280                 285             


Arg Glu Tyr Gly Ser Arg Val Ser Asn Leu His Met Tyr Ser Ala Val 
    290                 295                 300                 


Cys Thr Asp Val Ile Arg Arg Trp Val Tyr Pro Leu Thr Pro Glu Val 
305                 310                 315                 320 


Asn Phe Thr Asp Ser Ser Thr Gln Ser Tyr Thr His Ser Arg His Asn 
                325                 330                 335     


Ile Tyr Arg Gly Pro Glu Val Ser Leu Gly His Gly Ser Val Leu Glu 
            340                 345                 350         


Glu Asn Val Leu Leu Gly Ala Gly Thr Val Val Gly Ser Asn Cys Ser 
        355                 360                 365             


Ile Thr Asn Ser Val Ile Gly Pro Asn Cys His Ile Gly Asp Asn Val 
    370                 375                 380                 


Val Leu Asp Gln Ala Tyr Leu Trp Gln Gly Val Arg Val Ala Ala Gly 
385                 390                 395                 400 


Ala Gln Ile His Gln Ser Leu Leu Cys Asp Arg Ala Glu Val Lys Glu 
                405                 410                 415     


Arg Val Ile Leu Lys Pro His Cys Val Leu Thr Ser Gln Val Val Val 
            420                 425                 430         


Gly Pro Asp Ile Ile Leu Pro Glu Gly Ser Val Ile Ser Leu His Pro 
        435                 440                 445             


Pro Asp Ala Glu Glu Asp Glu Asp Asp Gly Gln Phe Ser Asp Asp Ser 
    450                 455                 460                 


Gly Ala Asp Gln Glu Lys Glu Lys Val Lys Leu Lys Gly Tyr Asn Pro 
465                 470                 475                 480 


Ala Glu Val Gly Pro Glu Gly Gln Gly Tyr Leu Trp Lys Ala Glu Asp 
                485                 490                 495     


Val Asp Glu Lys Glu Asp Glu Glu Leu Arg Gln Ser Leu Trp Gly Leu 
            500                 505                 510         


Met Ile Asn Met Glu Glu Glu Ser Glu Thr Glu Ser Glu Arg Ser Val 
        515                 520                 525             


Asp Pro Glu Glu Leu Asp Xaa Arg Ala Gly Ser Pro Gln Leu Asp Asp 
    530                 535                 540                 


Ile Arg Val Phe Gln Asn Glu Val Leu Gly Thr Leu Gln Arg Gly Arg 
545                 550                 555                 560 


Glu Glu Asn Ile Ser Cys Asp Asn Leu Val Leu Glu Ile Asn Ser Leu 
                565                 570                 575     


Lys Tyr Ala Tyr Asn Ile Ser Leu Lys Glu Val Met Gln Val Leu Ser 
            580                 585                 590         


His Val Val Leu Glu Phe Pro Leu Gln Gln Val Asp Gly Val Leu Asp 
        595                 600                 605             


Pro Asn Arg Tyr Cys Ala Leu Leu Leu Pro Leu Leu Lys Ala Trp Ser 
    610                 615                 620                 


Pro Val Phe Arg Asn Tyr Ile Lys Arg Ala Ala Asp His Leu Glu Ala 
625                 630                 635                 640 


Leu Ala Ala Ile Glu Asp Phe Phe Leu Glu His Glu Thr Leu Val Pro 
                645                 650                 655     


Ser Leu Ala Lys Val Leu Met Ala Phe Tyr Gln Leu Glu Ile Leu Ala 
            660                 665                 670         


Glu Glu Thr Ile Leu Ser Trp Phe Ser Gln Arg Asp Ile Thr Asp Lys 
        675                 680                 685             


Gly Gln Gln Leu Arg Lys Asn Gln Gln Leu Gln Arg Phe Ile Gln Trp 
    690                 695                 700                 


Leu Arg Glu Ala Glu Glu Glu Ser Ser Asp Asp Asp 
705                 710                 715     


<210>  206
<211>  143
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (140)..(140)
<223>  Xaa can be any naturally occurring amino acid

<400>  206

Met Ser Gly Arg Gly Lys Thr Gly Gly Lys Ala Arg Ala Lys Ala Lys 
1               5                   10                  15      


Ser Arg Ser Ser Arg Ala Gly Leu Gln Phe Pro Val Gly Arg Val His 
            20                  25                  30          


Arg Leu Leu Arg Lys Gly His Tyr Ala Glu Arg Val Gly Ala Gly Ala 
        35                  40                  45              


Pro Val Tyr Leu Ala Ala Val Leu Glu Tyr Leu Thr Ala Glu Ile Leu 
    50                  55                  60                  


Glu Leu Ala Gly Asn Ala Ala Arg Asp Asn Lys Lys Thr Arg Ile Ile 
65                  70                  75                  80  


Pro Arg His Leu Gln Leu Ala Ile Arg Asn Asp Glu Glu Leu Asn Lys 
                85                  90                  95      


Leu Leu Gly Gly Val Thr Ile Ala Gln Gly Gly Val Leu Pro Asn Ile 
            100                 105                 110         


Gln Ala Val Leu Leu Pro Lys Lys Thr Ser Ala Thr Val Gly Pro Lys 
        115                 120                 125             


Ala Pro Ser Gly Gly Lys Lys Ala Thr Gln Ala Xaa Gln Glu Tyr 
    130                 135                 140             


<210>  207
<211>  2773
<212>  PRT
<213>  Rattus norvegicus


<220>
<221>  misc_feature
<222>  (1589)..(1589)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (1755)..(1755)
<223>  Xaa can be any naturally occurring amino acid

<400>  207

Met Ser Asp Lys Met Ser Ser Phe Leu His Ile Gly Asp Ile Cys Ser 
1               5                   10                  15      


Leu Tyr Ala Glu Gly Ser Thr Asn Gly Phe Ile Ser Thr Leu Gly Leu 
            20                  25                  30          


Val Asp Asp Arg Cys Val Val Gln Pro Glu Ala Gly Asp Leu Asn Asn 
        35                  40                  45              


Pro Pro Lys Lys Phe Arg Asp Cys Leu Phe Lys Leu Cys Pro Met Asn 
    50                  55                  60                  


Arg Tyr Ser Ala Gln Lys Gln Phe Trp Lys Ala Ala Lys Pro Gly Ala 
65                  70                  75                  80  


Asn Ser Thr Thr Asp Ala Val Leu Leu Asn Lys Leu His His Ala Ala 
                85                  90                  95      


Asp Leu Glu Lys Lys Gln Asn Glu Thr Glu Asn Arg Lys Leu Leu Gly 
            100                 105                 110         


Thr Val Ile Gln Tyr Gly Asn Val Ile Gln Leu Leu His Leu Lys Ser 
        115                 120                 125             


Asn Lys Tyr Leu Thr Val Asn Lys Arg Leu Pro Ala Leu Leu Glu Lys 
    130                 135                 140                 


Asn Ala Met Arg Val Thr Leu Asp Glu Ala Gly Asn Glu Gly Ser Trp 
145                 150                 155                 160 


Phe Tyr Ile Gln Pro Phe Tyr Lys Leu Arg Ser Ile Gly Asp Ser Val 
                165                 170                 175     


Val Ile Gly Asp Lys Val Val Leu Asn Pro Val Asn Ala Gly Gln Pro 
            180                 185                 190         


Leu His Ala Ser Ser His Gln Leu Val Asp Asn Pro Gly Cys Asn Glu 
        195                 200                 205             


Val Asn Ser Val Asn Cys Asn Thr Ser Trp Lys Ile Val Leu Phe Met 
    210                 215                 220                 


Lys Trp Ser Asp Asn Lys Asp Asp Ile Leu Lys Gly Gly Asp Val Val 
225                 230                 235                 240 


Arg Leu Phe His Ala Glu Gln Glu Lys Phe Leu Thr Cys Asp Glu His 
                245                 250                 255     


Arg Lys Lys Gln His Val Phe Leu Arg Thr Thr Gly Arg Gln Ser Ala 
            260                 265                 270         


Thr Ser Ala Thr Ser Ser Lys Ala Leu Trp Glu Val Glu Val Val Gln 
        275                 280                 285             


His Asp Pro Cys Arg Gly Gly Ala Gly Tyr Trp Asn Ser Leu Phe Arg 
    290                 295                 300                 


Phe Lys His Leu Ala Thr Gly His Tyr Leu Ala Ala Glu Val Asp Pro 
305                 310                 315                 320 


Asp Phe Glu Glu Glu Cys Leu Glu Phe Gln Pro Ser Val Asp Pro Asp 
                325                 330                 335     


Gln Asp Ala Ser Arg Ser Arg Leu Arg Asn Ala Gln Glu Lys Met Val 
            340                 345                 350         


Tyr Ser Leu Val Ser Val Pro Glu Gly Asn Asp Ile Ser Ser Ile Phe 
        355                 360                 365             


Glu Leu Asp Pro Thr Thr Leu Arg Gly Gly Asp Ser Leu Val Pro Arg 
    370                 375                 380                 


Asn Ser Tyr Val Arg Leu Arg His Leu Cys Thr Asn Thr Trp Val His 
385                 390                 395                 400 


Ser Thr Asn Ile Pro Ile Asp Lys Glu Glu Glu Lys Pro Val Met Leu 
                405                 410                 415     


Lys Ile Gly Thr Ser Pro Leu Lys Glu Asp Lys Glu Ala Phe Ala Ile 
            420                 425                 430         


Val Pro Val Ser Pro Ala Glu Val Arg Asp Leu Asp Phe Ala Asn Asp 
        435                 440                 445             


Ala Ser Lys Val Leu Gly Ser Ile Ala Gly Lys Leu Glu Lys Gly Thr 
    450                 455                 460                 


Ile Thr Gln Asn Glu Arg Arg Ser Val Thr Lys Leu Leu Glu Asp Leu 
465                 470                 475                 480 


Val Tyr Phe Val Thr Gly Gly Thr Asn Ser Gly Gln Asp Val Leu Glu 
                485                 490                 495     


Val Val Phe Ser Lys Pro Asn Arg Glu Arg Gln Lys Leu Met Arg Glu 
            500                 505                 510         


Gln Asn Ile Leu Lys Gln Ile Phe Lys Leu Leu Gln Ala Pro Phe Thr 
        515                 520                 525             


Asp Cys Gly Asp Gly Pro Met Leu Arg Leu Glu Glu Leu Gly Asp Gln 
    530                 535                 540                 


Arg His Ala Pro Phe Arg His Ile Cys Arg Leu Cys Tyr Arg Val Leu 
545                 550                 555                 560 


Arg His Ser Gln Gln Asp Tyr Arg Lys Asn Gln Glu Tyr Ile Ala Lys 
                565                 570                 575     


Gln Phe Gly Phe Met Gln Lys Gln Ile Gly Tyr Asp Val Leu Ala Glu 
            580                 585                 590         


Asp Thr Ile Thr Ala Leu Leu His Asn Asn Arg Lys Leu Leu Glu Lys 
        595                 600                 605             


His Ile Thr Ala Ala Glu Ile Asp Thr Phe Val Ser Leu Val Arg Lys 
    610                 615                 620                 


Asn Arg Glu Pro Arg Phe Leu Asp Tyr Leu Ser Asp Leu Cys Val Ser 
625                 630                 635                 640 


Met Asn Lys Ser Ile Pro Val Thr Gln Glu Leu Ile Cys Lys Ala Val 
                645                 650                 655     


Leu Asn Pro Thr Asn Ala Asp Ile Leu Ile Glu Thr Lys Leu Val Leu 
            660                 665                 670         


Ser Arg Phe Glu Phe Glu Gly Val Ser Thr Gly Glu Asn Ala Leu Glu 
        675                 680                 685             


Ala Gly Glu Asp Glu Glu Glu Val Trp Leu Phe Trp Arg Asp Ser Asn 
    690                 695                 700                 


Lys Glu Ile Arg Ser Lys Ser Val Arg Glu Leu Ala Gln Asp Ala Lys 
705                 710                 715                 720 


Glu Gly Gln Lys Glu Asp Arg Asp Val Leu Ser Tyr Tyr Arg Tyr Gln 
                725                 730                 735     


Leu Asn Leu Phe Ala Arg Met Cys Leu Asp Arg Gln Tyr Leu Ala Ile 
            740                 745                 750         


Asn Glu Ile Ser Gly Gln Leu Asp Val Asp Leu Ile Leu Arg Cys Met 
        755                 760                 765             


Ser Asp Glu Asn Leu Pro Tyr Asp Leu Arg Ala Ser Phe Cys Arg Leu 
    770                 775                 780                 


Met Leu His Met His Val Asp Arg Asp Pro Gln Glu Gln Val Thr Pro 
785                 790                 795                 800 


Val Lys Tyr Ala Arg Leu Trp Ser Glu Ile Pro Ser Glu Ile Ala Ile 
                805                 810                 815     


Asp Asp Tyr Asp Ser Ser Gly Ala Ser Lys Asp Glu Ile Lys Glu Arg 
            820                 825                 830         


Phe Ala Gln Thr Met Glu Phe Val Glu Glu Tyr Leu Arg Asp Val Val 
        835                 840                 845             


Cys Gln Arg Phe Pro Phe Ser Asp Lys Glu Lys Asn Lys Leu Thr Phe 
    850                 855                 860                 


Glu Val Val Asn Leu Ala Arg Asn Leu Ile Tyr Phe Gly Phe Tyr Asn 
865                 870                 875                 880 


Phe Ser Asp Leu Leu Arg Leu Thr Lys Ile Leu Leu Ala Ile Leu Asp 
                885                 890                 895     


Cys Val His Val Thr Thr Ile Phe Pro Ile Ser Lys Met Thr Lys Gly 
            900                 905                 910         


Glu Glu Asn Lys Gly Ser Asn Val Met Arg Ser Ile His Gly Val Gly 
        915                 920                 925             


Glu Leu Met Thr Gln Val Val Leu Arg Gly Gly Gly Phe Leu Pro Met 
    930                 935                 940                 


Thr Pro Met Ala Ala Ala Pro Glu Gly Asn Val Lys Gln Ala Glu Pro 
945                 950                 955                 960 


Glu Lys Glu Asp Ile Met Val Met Asp Thr Lys Leu Lys Ile Ile Glu 
                965                 970                 975     


Ile Leu Gln Phe Ile Leu Asn Val Arg Leu Asp Tyr Arg Ile Ser Cys 
            980                 985                 990         


Leu Leu Cys Ile Phe Lys Arg Glu  Phe Asp Glu Ser Asn  Ser Gln Ser 
        995                 1000                 1005             


Ser Glu  Thr Ser Ser Gly Asn  Ser Ser Gln Glu Gly  Pro Ser Asn 
    1010                 1015                 1020             


Val Pro  Gly Ala Leu Asp Phe  Glu His Ile Glu Glu  Gln Ala Glu 
    1025                 1030                 1035             


Gly Ile  Phe Gly Gly Ser Glu  Glu Asn Thr Pro Leu  Asp Leu Asp 
    1040                 1045                 1050             


Asp His  Gly Gly Arg Thr Phe  Leu Arg Val Leu Leu  His Leu Thr 
    1055                 1060                 1065             


Met His  Asp Tyr Pro Pro Leu  Val Ser Gly Ala Leu  Gln Leu Leu 
    1070                 1075                 1080             


Phe Arg  His Phe Ser Gln Arg  Gln Glu Val Leu Gln  Ala Phe Lys 
    1085                 1090                 1095             


Gln Val  Gln Leu Leu Val Thr  Ser Gln Asp Val Asp  Asn Tyr Lys 
    1100                 1105                 1110             


Gln Ile  Lys Gln Asp Leu Asp  Gln Leu Arg Ser Ile  Val Glu Lys 
    1115                 1120                 1125             


Ser Glu  Leu Trp Val Tyr Lys  Gly Gln Gly Pro Asp  Glu Pro Met 
    1130                 1135                 1140             


Asp Gly  Ala Ser Gly Glu Asn  Glu His Lys Lys Thr  Glu Glu Gly 
    1145                 1150                 1155             


Thr Ser  Lys Pro Leu Lys His  Glu Ser Thr Ser Ser  Tyr Asn Tyr 
    1160                 1165                 1170             


Arg Val  Val Lys Glu Ile Leu  Ile Arg Leu Ser Lys  Leu Cys Val 
    1175                 1180                 1185             


Gln Glu  Ser Ala Ser Val Arg  Lys Ser Arg Lys Gln  Gln Gln Arg 
    1190                 1195                 1200             


Leu Leu  Arg Asn Met Gly Ala  His Ala Val Val Leu  Glu Leu Leu 
    1205                 1210                 1215             


Gln Ile  Pro Tyr Glu Lys Ala  Glu Asp Thr Lys Met  Gln Glu Ile 
    1220                 1225                 1230             


Met Arg  Leu Ala His Glu Phe  Leu Gln Asn Phe Cys  Ala Gly Asn 
    1235                 1240                 1245             


Gln Gln  Asn Gln Ala Leu Leu  His Lys His Ile Asn  Leu Phe Leu 
    1250                 1255                 1260             


Asn Pro  Gly Ile Leu Glu Ala  Val Thr Met Gln His  Ile Phe Met 
    1265                 1270                 1275             


Asn Asn  Phe Gln Leu Cys Ser  Glu Ile Asn Glu Arg  Val Val Gln 
    1280                 1285                 1290             


His Phe  Val His Cys Ile Glu  Thr His Gly Arg Asn  Val Gln Tyr 
    1295                 1300                 1305             


Ile Lys  Phe Leu Gln Thr Ile  Val Lys Ala Glu Gly  Lys Phe Ile 
    1310                 1315                 1320             


Lys Lys  Cys Gln Asp Met Val  Met Ala Glu Leu Val  Asn Ser Gly 
    1325                 1330                 1335             


Glu Asp  Val Leu Val Phe Tyr  Asn Asp Arg Ala Ser  Phe Gln Thr 
    1340                 1345                 1350             


Leu Ile  Gln Met Met Arg Ser  Glu Arg Asp Arg Met  Asp Glu Asn 
    1355                 1360                 1365             


Ser Pro  Leu Phe Met Tyr His  Ile His Leu Val Glu  Leu Leu Ala 
    1370                 1375                 1380             


Val Cys  Thr Glu Gly Lys Asn  Val Tyr Thr Glu Ile  Lys Cys Asn 
    1385                 1390                 1395             


Ser Leu  Leu Pro Leu Asp Asp  Ile Val Arg Val Val  Thr His Glu 
    1400                 1405                 1410             


Asp Cys  Ile Pro Glu Val Lys  Ile Ala Tyr Ile Asn  Phe Leu Asn 
    1415                 1420                 1425             


His Cys  Tyr Val Asp Thr Glu  Val Glu Met Lys Glu  Ile Tyr Thr 
    1430                 1435                 1440             


Ser Asn  His Met Trp Lys Leu  Phe Glu Asn Phe Leu  Val Asp Ile 
    1445                 1450                 1455             


Cys Arg  Ala Cys Asn Asn Thr  Ser Asp Arg Lys His  Ala Asp Ser 
    1460                 1465                 1470             


Val Leu  Glu Lys Tyr Val Thr  Glu Ile Val Met Ser  Ile Val Thr 
    1475                 1480                 1485             


Thr Phe  Phe Ser Ser Pro Phe  Ser Asp Gln Ser Thr  Thr Leu Gln 
    1490                 1495                 1500             


Thr Arg  Gln Pro Val Phe Val  Gln Leu Leu Gln Gly  Val Phe Arg 
    1505                 1510                 1515             


Val Tyr  His Cys Asn Trp Leu  Met Pro Ser Gln Lys  Ala Ser Val 
    1520                 1525                 1530             


Glu Ser  Cys Ile Arg Val Leu  Ser Asp Val Ala Lys  Ser Arg Ala 
    1535                 1540                 1545             


Ile Ala  Ile Pro Val Asp Leu  Asp Ser Gln Val Asn  Asn Leu Phe 
    1550                 1555                 1560             


Leu Lys  Ser His Asn Ile Val  Gln Lys Thr Ala Met  Asn Trp Arg 
    1565                 1570                 1575             


Leu Ser  Ala Arg Asn Ala Ala  Arg Arg Asp Xaa Val  Leu Ala Ala 
    1580                 1585                 1590             


Ser Arg  Asp Tyr Arg Asn Ile  Ile Glu Arg Leu Gln  Asp Ile Val 
    1595                 1600                 1605             


Ser Ala  Leu Glu Asp Arg Leu  Arg Pro Leu Val Gln  Ala Glu Leu 
    1610                 1615                 1620             


Ser Val  Leu Val Asp Val Leu  His Arg Pro Glu Leu  Leu Phe Pro 
    1625                 1630                 1635             


Glu Asn  Thr Asp Ala Arg Arg  Lys Cys Glu Ser Gly  Gly Phe Ile 
    1640                 1645                 1650             


Cys Lys  Leu Ile Lys His Thr  Lys Gln Leu Leu Glu  Glu Asn Glu 
    1655                 1660                 1665             


Glu Lys  Leu Cys Ile Lys Val  Leu Gln Thr Leu Arg  Glu Met Met 
    1670                 1675                 1680             


Thr Lys  Asp Arg Gly Tyr Gly  Glu Lys Gln Ile Ser  Ile Asp Glu 
    1685                 1690                 1695             


Leu Glu  Asn Ala Glu Leu Pro  Gln Pro Pro Glu Ala  Glu Asn Ser 
    1700                 1705                 1710             


Thr Glu  Glu Leu Glu Pro Ser  Pro Pro Leu Arg Gln  Leu Glu Asp 
    1715                 1720                 1725             


His Lys  Arg Gly Glu Ala Leu  Arg Gln Ile Leu Val  Asn Arg Tyr 
    1730                 1735                 1740             


Tyr Gly  Asn Ile Arg Pro Ser  Gly Arg Arg Glu Xaa  Leu Thr Ser 
    1745                 1750                 1755             


Phe Gly  Asn Gly Pro Leu Ser  Pro Gly Gly Pro Ser  Lys Pro Gly 
    1760                 1765                 1770             


Gly Gly  Gly Gly Gly Pro Gly  Ser Gly Ser Thr Ser  Arg Gly Glu 
    1775                 1780                 1785             


Met Ser  Leu Ala Glu Val Gln  Cys His Leu Asp Lys  Glu Gly Ala 
    1790                 1795                 1800             


Ser Asn  Leu Val Ile Asp Leu  Ile Met Asn Ala Ser  Ser Asp Arg 
    1805                 1810                 1815             


Val Phe  His Glu Ser Ile Leu  Leu Ala Ile Ala Leu  Leu Glu Gly 
    1820                 1825                 1830             


Gly Asn  Thr Thr Ile Gln His  Ser Phe Phe Cys Arg  Leu Thr Glu 
    1835                 1840                 1845             


Asp Lys  Lys Ser Glu Lys Phe  Phe Lys Val Phe Tyr  Asp Arg Met 
    1850                 1855                 1860             


Lys Val  Ala Gln Gln Glu Ile  Lys Ala Thr Val Thr  Val Asn Thr 
    1865                 1870                 1875             


Ser Asp  Leu Gly Asn Lys Lys  Lys Asp Asp Glu Val  Asp Arg Asp 
    1880                 1885                 1890             


Ala Pro  Ser Arg Lys Lys Ala  Lys Glu Pro Thr Thr  Gln Ile Thr 
    1895                 1900                 1905             


Glu Glu  Val Arg Asp Gln Leu  Leu Glu Ala Ser Ala  Ala Thr Arg 
    1910                 1915                 1920             


Lys Ala  Phe Thr Thr Phe Arg  Arg Glu Ala Asp Pro  Asp Asp His 
    1925                 1930                 1935             


Tyr Gln  Ser Gly Glu Gly Thr  Gln Ala Thr Thr Asp  Lys Ala Lys 
    1940                 1945                 1950             


Asp Asp  Leu Glu Met Ser Ala  Val Ile Thr Ile Met  Gln Pro Ile 
    1955                 1960                 1965             


Leu Arg  Phe Leu Gln Leu Leu  Cys Glu Asn His Asn  Arg Asp Leu 
    1970                 1975                 1980             


Gln Asn  Phe Leu Arg Cys Gln  Asn Asn Lys Thr Asn  Tyr Asn Leu 
    1985                 1990                 1995             


Val Cys  Glu Thr Leu Gln Phe  Leu Asp Cys Ile Cys  Gly Ser Thr 
    2000                 2005                 2010             


Thr Gly  Gly Leu Gly Leu Leu  Gly Leu Tyr Ile Asn  Glu Lys Asn 
    2015                 2020                 2025             


Val Ala  Leu Ile Asn Gln Thr  Leu Glu Ser Leu Thr  Glu Tyr Cys 
    2030                 2035                 2040             


Gln Gly  Pro Cys His Glu Asn  Gln Asn Cys Ile Ala  Thr His Glu 
    2045                 2050                 2055             


Ser Asn  Gly Ile Asp Ile Ile  Thr Ala Leu Ile Leu  Asn Asp Ile 
    2060                 2065                 2070             


Asn Pro  Leu Gly Lys Lys Arg  Met Asp Leu Val Leu  Glu Leu Lys 
    2075                 2080                 2085             


Asn Asn  Ala Ser Lys Leu Leu  Leu Ala Ile Met Glu  Ser Arg His 
    2090                 2095                 2100             


Asp Ser  Glu Asn Ala Glu Arg  Ile Leu Tyr Asn Met  Arg Pro Lys 
    2105                 2110                 2115             


Glu Leu  Val Glu Val Ile Lys  Lys Ala Tyr Met Gln  Gly Glu Val 
    2120                 2125                 2130             


Glu Phe  Glu Asp Gly Glu Asn  Gly Glu Asp Gly Ala  Ala Ser Pro 
    2135                 2140                 2145             


Arg Asn  Val Gly His Asn Ile  Tyr Ile Leu Ala His  Gln Leu Ala 
    2150                 2155                 2160             


Arg His  Asn Lys Glu Leu Gln  Thr Met Leu Lys Pro  Gly Gly Gln 
    2165                 2170                 2175             


Val Asp  Gly Asp Glu Ala Leu  Glu Phe Tyr Ala Lys  His Thr Ala 
    2180                 2185                 2190             


Gln Ile  Glu Ile Val Arg Leu  Asp Arg Thr Met Glu  Gln Ile Val 
    2195                 2200                 2205             


Phe Pro  Val Pro Ser Ile Cys  Glu Phe Leu Thr Lys  Glu Ser Lys 
    2210                 2215                 2220             


Leu Arg  Ile Tyr Tyr Thr Thr  Glu Arg Asp Glu Gln  Gly Ser Lys 
    2225                 2230                 2235             


Ile Asn  Asp Phe Phe Leu Arg  Ser Glu Asp Leu Phe  Asn Glu Met 
    2240                 2245                 2250             


Asn Trp  Gln Lys Lys Leu Arg  Ala Gln Pro Val Leu  Tyr Trp Cys 
    2255                 2260                 2265             


Ala Arg  Asn Met Ser Phe Trp  Ser Ser Ile Ser Phe  Asn Leu Ala 
    2270                 2275                 2280             


Val Leu  Met Asn Leu Leu Val  Ala Phe Phe Tyr Pro  Phe Lys Gly 
    2285                 2290                 2295             


Val Arg  Gly Gly Thr Leu Glu  Pro His Trp Ser Gly  Leu Leu Trp 
    2300                 2305                 2310             


Thr Ala  Met Leu Ile Ser Leu  Ala Ile Val Ile Ala  Leu Pro Lys 
    2315                 2320                 2325             


Pro His  Gly Ile Arg Ala Leu  Ile Ala Ser Thr Ile  Leu Arg Leu 
    2330                 2335                 2340             


Ile Phe  Ser Val Gly Leu Gln  Pro Thr Leu Phe Leu  Leu Gly Ala 
    2345                 2350                 2355             


Phe Asn  Val Cys Asn Lys Ile  Ile Phe Leu Met Ser  Phe Val Gly 
    2360                 2365                 2370             


Asn Cys  Gly Thr Phe Thr Arg  Gly Tyr Arg Ala Met  Val Leu Asp 
    2375                 2380                 2385             


Val Glu  Phe Leu Tyr His Leu  Leu Tyr Leu Leu Ile  Cys Ala Met 
    2390                 2395                 2400             


Gly Leu  Phe Val His Glu Phe  Phe Tyr Ser Leu Leu  Leu Phe Asp 
    2405                 2410                 2415             


Leu Val  Tyr Arg Glu Glu Thr  Leu Leu Asn Val Ile  Lys Ser Val 
    2420                 2425                 2430             


Thr Arg  Asn Gly Arg Pro Ile  Ile Leu Thr Ala Ala  Leu Ala Leu 
    2435                 2440                 2445             


Ile Leu  Val Tyr Leu Phe Ser  Ile Val Gly Tyr Leu  Phe Phe Lys 
    2450                 2455                 2460             


Asp Asp  Phe Ile Leu Glu Val  Asp Arg Leu Pro Asn  Glu Thr Ala 
    2465                 2470                 2475             


Gly Pro  Glu Thr Gly Glu Ser  Leu Ala Asn Asp Phe  Leu Tyr Ser 
    2480                 2485                 2490             


Asp Val  Cys Arg Val Glu Thr  Gly Glu Asn Cys Thr  Ser Pro Ala 
    2495                 2500                 2505             


Pro Lys  Glu Glu Leu Leu Pro  Val Glu Glu Thr Glu  Gln Asp Lys 
    2510                 2515                 2520             


Glu His  Thr Cys Glu Thr Leu  Leu Met Cys Ile Val  Thr Val Leu 
    2525                 2530                 2535             


Ser His  Gly Leu Arg Ser Gly  Gly Gly Val Gly Asp  Val Leu Arg 
    2540                 2545                 2550             


Lys Pro  Ser Lys Glu Glu Pro  Leu Phe Ala Ala Arg  Val Ile Tyr 
    2555                 2560                 2565             


Asp Leu  Leu Phe Phe Phe Met  Val Ile Ile Ile Val  Leu Asn Leu 
    2570                 2575                 2580             


Ile Phe  Gly Val Ile Ile Asp  Thr Phe Ala Asp Leu  Arg Ser Glu 
    2585                 2590                 2595             


Lys Gln  Lys Lys Glu Glu Ile  Leu Lys Thr Thr Cys  Phe Ile Cys 
    2600                 2605                 2610             


Gly Leu  Glu Arg Asp Lys Phe  Asp Asn Lys Thr Val  Thr Phe Glu 
    2615                 2620                 2625             


Glu His  Ile Lys Glu Glu His  Asn Met Trp His Tyr  Leu Cys Phe 
    2630                 2635                 2640             


Ile Val  Leu Val Lys Val Lys  Asp Ser Thr Glu Tyr  Thr Gly Pro 
    2645                 2650                 2655             


Glu Ser  Tyr Val Ala Glu Met  Ile Arg Glu Arg Asn  Leu Asp Trp 
    2660                 2665                 2670             


Phe Pro  Arg Met Arg Ala Met  Ser Leu Val Ser Ser  Asp Ser Glu 
    2675                 2680                 2685             


Gly Glu  Gln Asn Glu Leu Arg  Asn Leu Gln Glu Lys  Leu Glu Ser 
    2690                 2695                 2700             


Thr Met  Lys Leu Val Thr Asn  Leu Ser Gly Gln Leu  Ser Glu Leu 
    2705                 2710                 2715             


Lys Asp  Gln Met Thr Glu Gln  Arg Lys Gln Lys Gln  Arg Ile Gly 
    2720                 2725                 2730             


Leu Leu  Gly His Pro Pro His  Met Asn Val Asn Pro  Gln Gln Pro 
    2735                 2740                 2745             


Ala Phe  Leu Leu Leu Glu Asn  Gly Thr His Arg Glu  Gly Leu Ala 
    2750                 2755                 2760             


Thr Arg  Ser Glu Gln Glu Asn  Cys Glu Ser 
    2765                 2770             


<210>  208
<211>  518
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Asp Gln Thr Pro Pro Ala Arg Pro Glu Tyr Leu Val Ser Gly Ile 
1               5                   10                  15      


Arg Thr Pro Pro Val Arg Arg Asn Ser Lys Leu Ala Thr Leu Gly Arg 
            20                  25                  30          


Ile Phe Lys Pro Trp Lys Trp Arg Lys Lys Lys Asn Glu Lys Leu Lys 
        35                  40                  45              


Gln Thr Thr Ser Ala Leu Glu Lys Lys Met Ala Gly Arg Gln Gly Arg 
    50                  55                  60                  


Glu Glu Leu Ile Lys Lys Gly Leu Leu Glu Met Met Glu Gln Asp Ala 
65                  70                  75                  80  


Glu Ser Lys Thr Cys Asn Pro Asp Gly Gly Pro Arg Ser Val Gln Ser 
                85                  90                  95      


Glu Pro Pro Thr Pro Lys Ser Glu Thr Leu Thr Ser Glu Asp Ala Gln 
            100                 105                 110         


Pro Gly Ser Pro Leu Ala Thr Gly Thr Asp Gln Val Ser Leu Asp Lys 
        115                 120                 125             


Pro Leu Ser Ser Ala Ala His Leu Asp Asp Ala Ala Lys Met Pro Ser 
    130                 135                 140                 


Ala Ser Ser Gly Glu Glu Ala Asp Ala Gly Ser Leu Leu Pro Thr Thr 
145                 150                 155                 160 


Asn Glu Leu Ser Gln Ala Leu Ala Gly Ala Asp Ser Leu Asp Ser Pro 
                165                 170                 175     


Pro Arg Pro Leu Glu Arg Ser Val Gly Gln Leu Pro Ser Pro Pro Leu 
            180                 185                 190         


Leu Pro Thr Pro Pro Pro Lys Ala Ser Ser Lys Thr Thr Lys Asn Val 
        195                 200                 205             


Thr Gly Gln Ala Thr Leu Phe Gln Ala Ser Ser Met Lys Ser Ala Asp 
    210                 215                 220                 


Pro Ser Leu Arg Gly Gln Leu Ser Thr Pro Thr Gly Ser Pro His Leu 
225                 230                 235                 240 


Thr Thr Val His Arg Pro Leu Pro Pro Ser Arg Val Ile Glu Glu Leu 
                245                 250                 255     


His Arg Ala Leu Ala Thr Lys His Arg Gln Asp Ser Phe Gln Gly Arg 
            260                 265                 270         


Glu Ser Lys Gly Ser Pro Lys Arg Arg Leu Asp Val Arg Leu Ser Arg 
        275                 280                 285             


Thr Ser Ser Val Glu Arg Gly Lys Glu Arg Glu Glu Ala Trp Ser Phe 
    290                 295                 300                 


Asp Gly Ala Leu Glu Asn Lys Arg Thr Ala Ala Lys Glu Ser Glu Glu 
305                 310                 315                 320 


Asn Lys Glu Asn Leu Ile Ile Asn Ser Glu Leu Lys Asp Asp Leu Leu 
                325                 330                 335     


Leu Tyr Gln Asp Glu Glu Ala Leu Asn Asp Ser Ile Ile Ser Gly Thr 
            340                 345                 350         


Leu Pro Arg Lys Cys Arg Lys Glu Leu Leu Ala Val Lys Leu Arg Asn 
        355                 360                 365             


Arg Pro Ser Lys Gln Glu Leu Glu Asp Arg Asn Ile Phe Pro Arg Arg 
    370                 375                 380                 


Thr Asp Glu Glu Arg Gln Glu Ile Arg Gln Gln Ile Glu Met Lys Leu 
385                 390                 395                 400 


Ser Lys Arg Leu Ser Gln Arg Pro Ala Val Glu Glu Leu Glu Arg Arg 
                405                 410                 415     


Asn Ile Leu Lys Gln Arg Asn Asp Gln Thr Glu Gln Glu Glu Arg Arg 
            420                 425                 430         


Glu Ile Lys Gln Arg Leu Thr Arg Lys Leu Asn Gln Arg Pro Thr Val 
        435                 440                 445             


Asp Glu Leu Arg Asp Arg Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val 
    450                 455                 460                 


Glu Val Ala Lys Ala Gln Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp 
465                 470                 475                 480 


Thr Arg Leu Ser Ala Ala Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn 
                485                 490                 495     


Glu Tyr Lys Ser Asn Glu Met Glu Val His Ala Ser Ser Lys His Leu 
            500                 505                 510         


Thr Arg Phe His Arg Pro 
        515             


<210>  209
<211>  940
<212>  PRT
<213>  Homo sapiens

<400>  209

Met Gly Ser Gly Pro Ile Asp Pro Lys Glu Leu Leu Lys Gly Leu Asp 
1               5                   10                  15      


Ser Phe Leu Asn Arg Asp Gly Glu Val Lys Ser Val Asp Gly Ile Ser 
            20                  25                  30          


Lys Ile Phe Ser Leu Met Lys Glu Ala Arg Lys Met Val Ser Arg Cys 
        35                  40                  45              


Thr Tyr Leu Asn Ile Leu Leu Gln Thr Arg Ser Pro Glu Ile Leu Val 
    50                  55                  60                  


Lys Phe Ile Asp Val Gly Gly Tyr Lys Leu Leu Asn Asn Trp Leu Thr 
65                  70                  75                  80  


Tyr Ser Lys Thr Thr Asn Asn Ile Pro Leu Leu Gln Gln Ile Leu Leu 
                85                  90                  95      


Thr Leu Gln His Leu Pro Leu Thr Val Asp His Leu Lys Gln Asn Asn 
            100                 105                 110         


Thr Ala Lys Leu Val Lys Gln Leu Ser Lys Ser Ser Glu Asp Glu Glu 
        115                 120                 125             


Leu Arg Lys Leu Ala Ser Val Leu Val Ser Asp Trp Met Ala Val Ile 
    130                 135                 140                 


Arg Ser Gln Ser Ser Thr Gln Pro Ala Glu Lys Asp Lys Lys Lys Arg 
145                 150                 155                 160 


Lys Asp Glu Gly Lys Ser Arg Thr Thr Leu Pro Glu Arg Pro Leu Thr 
                165                 170                 175     


Glu Val Lys Ala Glu Thr Arg Ala Glu Glu Ala Pro Glu Lys Lys Arg 
            180                 185                 190         


Glu Lys Pro Lys Ser Leu Arg Thr Thr Ala Pro Ser His Ala Lys Phe 
        195                 200                 205             


Arg Ser Thr Gly Leu Glu Leu Glu Thr Pro Ser Leu Val Pro Val Lys 
    210                 215                 220                 


Lys Asn Ala Ser Thr Val Val Val Ser Asp Lys Tyr Asn Leu Lys Pro 
225                 230                 235                 240 


Ile Pro Leu Lys Arg Gln Ser Asn Val Ala Ala Pro Gly Asp Ala Thr 
                245                 250                 255     


Pro Pro Ala Glu Lys Lys Tyr Lys Pro Leu Asn Thr Thr Pro Asn Ala 
            260                 265                 270         


Thr Lys Glu Ile Lys Val Lys Ile Ile Pro Pro Gln Pro Met Glu Gly 
        275                 280                 285             


Leu Gly Phe Leu Asp Ala Leu Asn Ser Ala Pro Val Pro Gly Ile Lys 
    290                 295                 300                 


Ile Lys Lys Lys Lys Lys Val Leu Ser Pro Thr Ala Ala Lys Pro Ser 
305                 310                 315                 320 


Pro Phe Glu Gly Lys Thr Ser Thr Glu Pro Ser Thr Ala Lys Pro Ser 
                325                 330                 335     


Ser Pro Glu Pro Ala Pro Pro Ser Glu Ala Met Asp Ala Asp Arg Pro 
            340                 345                 350         


Gly Thr Pro Val Pro Pro Val Glu Val Pro Glu Leu Met Asp Thr Ala 
        355                 360                 365             


Ser Leu Glu Pro Gly Ala Leu Asp Ala Lys Pro Val Glu Ser Pro Gly 
    370                 375                 380                 


Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val Thr 
385                 390                 395                 400 


Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu Asp 
                405                 410                 415     


Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu Ala 
            420                 425                 430         


Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala Arg 
        435                 440                 445             


Arg Leu Ser His Asp Asn Met Glu Glu Lys Val Pro Trp Val Cys Pro 
    450                 455                 460                 


Arg Pro Leu Val Leu Pro Ser Pro Leu Val Thr Pro Gly Ser Asn Ser 
465                 470                 475                 480 


Gln Glu Arg Tyr Ile Gln Ala Glu Arg Glu Lys Gly Ile Leu Gln Glu 
                485                 490                 495     


Leu Phe Leu Asn Lys Glu Ser Pro His Glu Pro Asp Pro Glu Pro Tyr 
            500                 505                 510         


Glu Pro Ile Pro Pro Lys Leu Ile Pro Leu Asp Glu Glu Cys Ser Met 
        515                 520                 525             


Asp Glu Thr Pro Tyr Val Glu Thr Leu Glu Pro Gly Gly Ser Gly Gly 
    530                 535                 540                 


Ser Pro Asp Gly Ala Gly Gly Ser Lys Leu Pro Pro Val Leu Ala Asn 
545                 550                 555                 560 


Leu Met Gly Ser Met Gly Ala Gly Lys Gly Pro Gln Gly Pro Gly Gly 
                565                 570                 575     


Gly Gly Ile Asn Val Gln Glu Ile Leu Thr Ser Ile Met Gly Ser Pro 
            580                 585                 590         


Asn Ser His Pro Ser Glu Glu Leu Leu Lys Gln Pro Asp Tyr Ser Asp 
        595                 600                 605             


Lys Ile Lys Gln Met Leu Val Pro His Gly Leu Leu Gly Pro Gly Pro 
    610                 615                 620                 


Ile Ala Asn Gly Phe Pro Pro Gly Gly Pro Gly Gly Pro Lys Gly Met 
625                 630                 635                 640 


Gln His Phe Pro Pro Gly Pro Gly Gly Pro Met Pro Gly Pro His Gly 
                645                 650                 655     


Gly Pro Gly Gly Pro Val Gly Pro Arg Leu Leu Gly Pro Pro Pro Pro 
            660                 665                 670         


Pro Arg Gly Gly Asp Pro Phe Trp Asp Gly Pro Gly Asp Pro Met Arg 
        675                 680                 685             


Gly Gly Pro Met Arg Gly Gly Pro Gly Pro Gly Pro Gly Pro Tyr His 
    690                 695                 700                 


Arg Gly Arg Gly Gly Arg Gly Gly Asn Glu Pro Pro Pro Pro Pro Pro 
705                 710                 715                 720 


Pro Phe Arg Gly Ala Arg Gly Gly Arg Ser Gly Gly Gly Pro Pro Asn 
                725                 730                 735     


Gly Arg Gly Gly Pro Gly Gly Gly Met Val Gly Gly Gly Gly His Arg 
            740                 745                 750         


Pro His Glu Gly Pro Gly Gly Gly Met Gly Asn Ser Ser Gly His Arg 
        755                 760                 765             


Pro His Glu Gly Pro Gly Gly Gly Met Gly Ser Gly His Arg Pro His 
    770                 775                 780                 


Glu Gly Pro Gly Gly Ser Met Gly Gly Gly Gly Gly His Arg Pro His 
785                 790                 795                 800 


Glu Gly Pro Gly Gly Gly Ile Ser Gly Gly Ser Gly His Arg Pro His 
                805                 810                 815     


Glu Gly Pro Gly Gly Gly Met Gly Ala Gly Gly Gly His Arg Pro His 
            820                 825                 830         


Glu Gly Pro Gly Gly Ser Met Gly Gly Ser Gly Gly His Arg Pro His 
        835                 840                 845             


Glu Gly Pro Gly His Gly Gly Pro His Gly His Arg Pro His Asp Val 
    850                 855                 860                 


Pro Gly His Arg Gly His Asp His Arg Gly Pro Pro Pro His Glu His 
865                 870                 875                 880 


Arg Gly His Asp Gly Pro Gly His Gly Gly Gly Gly His Arg Gly His 
                885                 890                 895     


Asp Gly Gly His Ser His Gly Gly Asp Met Ser Asn Arg Pro Val Cys 
            900                 905                 910         


Arg His Phe Met Met Lys Gly Asn Cys Arg Tyr Glu Asn Asn Cys Ala 
        915                 920                 925             


Phe Tyr His Pro Gly Val Asn Gly Pro Pro Leu Pro 
    930                 935                 940 


<210>  210
<211>  171
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (67)..(67)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (75)..(75)
<223>  Xaa can be any naturally occurring amino acid

<400>  210

Met Glu Gln Asp Asn Ser Pro Gln Lys Ile Gln Phe Thr Val Pro Leu 
1               5                   10                  15      


Leu Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg 
            20                  25                  30          


Arg Pro Xaa Pro Ala Thr Leu Val Leu Thr Ser Asp Gln Ser Ser Pro 
        35                  40                  45              


Glu Ile Asp Glu Asp Arg Ile Pro Asn Pro His Leu Lys Ser Thr Leu 
    50                  55                  60                  


Ala Met Xaa Pro Arg Gln Arg Lys Lys Met Xaa Arg Ile Thr Pro Thr 
65                  70                  75                  80  


Met Lys Glu Leu Gln Met Met Val Glu His His Leu Gly Gln Gln Gln 
                85                  90                  95      


Gln Gly Glu Glu Pro Glu Gly Ala Ala Glu Ser Thr Gly Thr Gln Glu 
            100                 105                 110         


Ser Arg Pro Pro Gly Ile Pro Asp Thr Glu Val Glu Ser Arg Leu Gly 
        115                 120                 125             


Thr Ser Gly Thr Ala Lys Lys Thr Ala Glu Cys Ile Pro Lys Thr His 
    130                 135                 140                 


Glu Arg Gly Ser Lys Glu Pro Ser Thr Lys Glu Pro Ser Thr His Ile 
145                 150                 155                 160 


Pro Pro Leu Asp Ser Lys Gly Ala Asn Ser Val 
                165                 170     


<210>  211
<211>  1098
<212>  PRT
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (371)..(371)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (461)..(461)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (915)..(915)
<223>  Xaa can be any naturally occurring amino acid

<400>  211

Met Leu Lys Thr Glu Ser Ser Gly Glu Arg Thr Thr Leu Arg Ser Ala 
1               5                   10                  15      


Ser Pro His Arg Asn Ala Tyr Arg Thr Glu Phe Gln Ala Leu Lys Ser 
            20                  25                  30          


Thr Phe Asp Lys Pro Lys Ser Asp Gly Glu Gln Lys Thr Lys Glu Gly 
        35                  40                  45              


Glu Gly Ser Gln Gln Ser Arg Gly Arg Lys Tyr Gly Ser Asn Val Asn 
    50                  55                  60                  


Arg Ile Lys Asn Leu Phe Met Gln Met Gly Met Glu Pro Asn Glu Asn 
65                  70                  75                  80  


Ala Ala Val Ile Ala Lys Thr Arg Gly Lys Gly Gly His Ser Ser Pro 
                85                  90                  95      


Gln Arg Arg Met Lys Pro Lys Glu Phe Leu Glu Lys Thr Asp Gly Ser 
            100                 105                 110         


Val Val Lys Leu Glu Ser Ser Val Ser Glu Arg Ile Ser Arg Phe Asp 
        115                 120                 125             


Thr Met Tyr Asp Gly Pro Ser Tyr Ser Lys Phe Thr Glu Thr Arg Lys 
    130                 135                 140                 


Met Phe Glu Arg Ser Val His Glu Ser Gly Gln Asn Asn Arg Tyr Ser 
145                 150                 155                 160 


Pro Lys Lys Glu Lys Ala Gly Gly Ser Glu Pro Gln Asp Glu Trp Gly 
                165                 170                 175     


Gly Ser Lys Ser Asn Arg Gly Ser Thr Asp Ser Leu Asp Ser Leu Ser 
            180                 185                 190         


Ser Arg Thr Glu Ala Val Ser Pro Thr Val Ser Gln Leu Ser Ala Val 
        195                 200                 205             


Phe Glu Asn Thr Asp Ser Pro Ser Ala Ile Ile Ser Glu Lys Ala Glu 
    210                 215                 220                 


Asn Asn Glu Tyr Ser Val Thr Gly His Tyr Pro Leu Asn Leu Pro Ser 
225                 230                 235                 240 


Val Thr Val Thr Asn Leu Asp Thr Phe Gly His Leu Lys Asp Ser Asn 
                245                 250                 255     


Ser Trp Pro Pro Ser Asn Lys Arg Gly Val Asp Thr Glu Asp Ala His 
            260                 265                 270         


Lys Ser Asn Ala Thr Pro Val Pro Glu Val Ala Ser Lys Ser Thr Ser 
        275                 280                 285             


Leu Ala Ser Ile Pro Gly Glu Glu Ile Gln Gln Ser Lys Glu Pro Glu 
    290                 295                 300                 


Asp Ser Thr Ser Asn Gln Gln Thr Pro Asp Ser Ile Asp Lys Asp Gly 
305                 310                 315                 320 


Pro Glu Glu Pro Cys Ala Glu Ser Lys Ala Met Pro Lys Ser Glu Ile 
                325                 330                 335     


Pro Ser Pro Gln Ser Gln Leu Leu Glu Asp Ala Glu Ala Asn Leu Val 
            340                 345                 350         


Gly Arg Glu Ala Ala Lys Gln Gln Arg Lys Glu Leu Ala Gly Gly Asp 
        355                 360                 365             


Phe Thr Xaa Pro Asp Ala Ser Ala Ser Ser Cys Gly Lys Glu Val Pro 
    370                 375                 380                 


Glu Asp Ser Asn Asn Phe Asp Gly Ser His Val Tyr Met His Ser Asp 
385                 390                 395                 400 


Tyr Asn Val Tyr Arg Val Arg Ser Arg Tyr Asn Ser Asp Trp Gly Glu 
                405                 410                 415     


Thr Gly Thr Glu Gln Asp Glu Glu Glu Asp Ser Asp Glu Asn Ser Tyr 
            420                 425                 430         


Tyr Gln Pro Asp Met Glu Tyr Ser Glu Ile Val Gly Leu Pro Glu Glu 
        435                 440                 445             


Glu Glu Ile Pro Ala Asn Arg Lys Ile Lys Phe Ser Xaa Ala Pro Ile 
    450                 455                 460                 


Lys Val Phe Asn Thr Tyr Ser Asn Glu Asp Tyr Asp Arg Arg Asn Asp 
465                 470                 475                 480 


Glu Val Asp Pro Val Ala Ala Ser Ala Glu Tyr Glu Leu Glu Lys Arg 
                485                 490                 495     


Val Glu Lys Leu Glu Leu Phe Pro Val Glu Leu Glu Lys Asp Glu Asp 
            500                 505                 510         


Gly Leu Gly Ile Ser Ile Ile Gly Met Gly Val Gly Ala Asp Ala Gly 
        515                 520                 525             


Leu Glu Lys Leu Gly Ile Phe Val Lys Thr Val Thr Glu Gly Gly Ala 
    530                 535                 540                 


Ala Gln Arg Asp Gly Arg Ile Gln Val Asn Asp Gln Ile Val Glu Val 
545                 550                 555                 560 


Asp Gly Ile Ser Leu Val Gly Val Thr Gln Asn Phe Ala Ala Thr Val 
                565                 570                 575     


Leu Arg Asn Thr Lys Gly Asn Val Arg Phe Val Ile Gly Arg Glu Lys 
            580                 585                 590         


Pro Gly Gln Val Ser Glu Val Ala Gln Leu Ile Ser Gln Thr Leu Glu 
        595                 600                 605             


Gln Glu Arg Arg Gln Arg Glu Leu Leu Glu Gln His Tyr Ala Gln Tyr 
    610                 615                 620                 


Asp Ala Asp Asp Asp Glu Thr Gly Glu Tyr Ala Thr Asp Glu Glu Glu 
625                 630                 635                 640 


Asp Glu Val Gly Pro Val Leu Pro Gly Ser Asp Met Ala Ile Glu Val 
                645                 650                 655     


Phe Glu Leu Pro Glu Asn Glu Asp Met Phe Ser Pro Ser Glu Leu Asp 
            660                 665                 670         


Thr Ser Lys Leu Ser His Lys Phe Lys Glu Leu Gln Ile Lys His Ala 
        675                 680                 685             


Val Thr Glu Ala Glu Ile Gln Lys Leu Lys Thr Lys Leu Gln Ala Ala 
    690                 695                 700                 


Glu Asn Glu Lys Val Arg Trp Glu Leu Glu Lys Thr Gln Leu Gln Gln 
705                 710                 715                 720 


Asn Ile Glu Glu Asn Lys Glu Arg Met Leu Lys Leu Glu Ser Tyr Trp 
                725                 730                 735     


Ile Glu Ala Gln Thr Leu Cys His Thr Val Asn Glu His Leu Lys Glu 
            740                 745                 750         


Thr Gln Ser Gln Tyr Gln Ala Leu Glu Lys Lys Tyr Asn Lys Ala Lys 
        755                 760                 765             


Lys Leu Ile Lys Asp Phe Gln Gln Lys Glu Leu Asp Phe Ile Lys Arg 
    770                 775                 780                 


Gln Glu Ala Glu Arg Lys Lys Ile Glu Asp Leu Glu Lys Ala His Leu 
785                 790                 795                 800 


Val Glu Val Gln Gly Leu Gln Val Arg Ile Arg Asp Leu Glu Ala Glu 
                805                 810                 815     


Val Phe Arg Leu Leu Lys Gln Asn Gly Thr Gln Val Asn Asn Asn Asn 
            820                 825                 830         


Asn Ile Phe Glu Arg Arg Thr Ser Leu Gly Glu Val Ser Lys Gly Asp 
        835                 840                 845             


Thr Met Glu Asn Leu Asp Gly Lys Gln Thr Ser Cys Gln Asp Gly Leu 
    850                 855                 860                 


Ser Gln Asp Leu Asn Glu Ala Val Pro Glu Thr Glu Arg Leu Asp Ser 
865                 870                 875                 880 


Lys Ala Leu Lys Thr Arg Ala Gln Leu Ser Val Lys Asn Arg Arg Gln 
                885                 890                 895     


Arg Pro Ser Arg Thr Arg Leu Tyr Asp Ser Val Ser Ser Thr Asp Gly 
            900                 905                 910         


Glu Asp Xaa Leu Glu Arg Lys Asn Phe Thr Phe Asn Asp Asp Phe Ser 
        915                 920                 925             


Pro Ser Ser Thr Ser Ser Ala Asp Leu Ser Gly Leu Gly Ala Glu Pro 
    930                 935                 940                 


Lys Thr Pro Gly Leu Ser Gln Ser Leu Ala Leu Ser Ser Asp Glu Ser 
945                 950                 955                 960 


Leu Asp Met Ile Asp Asp Glu Ile Leu Asp Asp Gly Gln Ser Pro Lys 
                965                 970                 975     


His Ser Gln Cys Gln Asn Arg Ala Val Gln Glu Trp Ser Val Gln Gln 
            980                 985                 990         


Val Ser His Trp Leu Met Ser Leu  Asn Leu Glu Gln Tyr  Val Ser Glu 
        995                 1000                 1005             


Phe Ser  Ala Gln Asn Ile Thr  Gly Glu Gln Leu Leu  Gln Leu Asp 
    1010                 1015                 1020             


Gly Asn  Lys Leu Lys Ala Leu  Gly Met Thr Ala Ser  Gln Asp Arg 
    1025                 1030                 1035             


Ala Val  Val Lys Lys Lys Leu  Lys Glu Met Lys Met  Ser Leu Glu 
    1040                 1045                 1050             


Lys Ala  Arg Lys Ala Gln Glu  Lys Met Glu Lys Gln  Arg Glu Lys 
    1055                 1060                 1065             


Leu Arg  Arg Lys Glu Gln Glu  Gln Met Gln Arg Lys  Ser Lys Lys 
    1070                 1075                 1080             


Thr Glu  Lys Met Thr Ser Thr  Thr Ala Glu Gly Ala  Gly Glu Gln 
    1085                 1090                 1095             


<210>  212
<211>  40
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (18)..(18)
<223>  Xaa can be any naturally occurring amino acid

<400>  212

Lys Ile Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg 
1               5                   10                  15      


Thr Xaa Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu 
            20                  25                  30          


Gly Arg Met His Asp Glu Lys Val 
        35                  40  


<210>  213
<211>  34
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa can be any naturally occurring amino acid

<400>  213

Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile Gly Xaa Glu 
1               5                   10                  15      


Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln Lys Thr Lys Val Lys 
            20                  25                  30          


Phe Asp 
        


<210>  214
<211>  44
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (10)..(10)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (34)..(34)
<223>  Xaa can be any naturally occurring amino acid

<400>  214

Ala Val Glu Ile Arg Ser Arg His Ser Xaa Tyr Pro Ala Gly Thr Glu 
1               5                   10                  15      


Asp Asp Glu Gly Met Gly Glu Glu Pro Ser Pro Phe Arg Gly Arg Ser 
            20                  25                  30          


Arg Xaa Ala Pro Pro Asn Leu Trp Ala Ala Gln Arg 
        35                  40                  


<210>  215
<211>  43
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (25)..(25)
<223>  Xaa can be any naturally occurring amino acid

<400>  215

Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn Pro Tyr Arg 
1               5                   10                  15      


Ile Pro Pro Leu Phe Pro Ile Lys Xaa Phe Val Lys Thr Lys Cys Lys 
            20                  25                  30          


Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His 
        35                  40              


<210>  216
<211>  32
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (13)..(13)
<223>  Xaa can be any naturally occurring amino acid

<400>  216

Glu Ser Glu Arg Ser Val Asp Pro Glu Glu Leu Asp Xaa Arg Ala Gly 
1               5                   10                  15      


Ser Pro Gln Leu Asp Asp Ile Arg Val Phe Gln Asn Glu Val Leu Gly 
            20                  25                  30          


<210>  217
<211>  30
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  Xaa can be any naturally occurring amino acid

<400>  217

Ala Val Leu Leu Pro Lys Lys Thr Ser Ala Thr Val Gly Pro Lys Ala 
1               5                   10                  15      


Pro Ser Gly Gly Lys Lys Ala Thr Gln Ala Xaa Gln Glu Tyr 
            20                  25                  30  


<210>  218
<211>  39
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (20)..(20)
<223>  Xaa can be any naturally occurring amino acid

<400>  218

Val Gln Lys Thr Ala Met Asn Trp Arg Leu Ser Ala Arg Asn Ala Ala 
1               5                   10                  15      


Arg Arg Asp Xaa Val Leu Ala Ala Ser Arg Asp Tyr Arg Asn Ile Ile 
            20                  25                  30          


Glu Arg Leu Gln Asp Ile Val 
        35                  


<210>  219
<211>  35
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa can be any naturally occurring amino acid

<400>  219

Leu Val Asn Arg Tyr Tyr Gly Asn Ile Arg Pro Ser Gly Arg Arg Glu 
1               5                   10                  15      


Xaa Leu Thr Ser Phe Gly Asn Gly Pro Leu Ser Pro Gly Gly Pro Ser 
            20                  25                  30          


Lys Pro Gly 
        35  


<210>  220
<211>  57
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  220

Leu Arg Asp Arg Lys Ile Leu Ile Arg Phe Ser Asp Tyr Val Glu Val 
1               5                   10                  15      


Ala Lys Ala Gln Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp Thr Arg 
            20                  25                  30          


Leu Ser Ala Ala Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn Glu Tyr 
        35                  40                  45              


Lys Ser Asn Glu Met Glu Val His Ala 
    50                  55          


<210>  221
<211>  66
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  221

Gly Asp Pro Asn Gln Leu Thr Arg Lys Gly Arg Lys Arg Lys Ser Val 
1               5                   10                  15      


Thr Trp Pro Glu Glu Gly Lys Leu Arg Glu Tyr Phe Tyr Phe Glu Leu 
            20                  25                  30          


Asp Glu Thr Glu Arg Val Asn Val Asn Lys Ile Lys Asp Phe Gly Glu 
        35                  40                  45              


Ala Ala Lys Arg Glu Ile Leu Ser Asp Arg His Ala Phe Glu Thr Ala 
    50                  55                  60                  


Arg Arg 
65      


<210>  222
<211>  65
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (47)..(47)
<223>  Xaa can be any naturally occurring amino acid

<400>  222

Gly Glu Thr Gly Thr Glu Gln Asp Glu Glu Glu Asp Ser Asp Glu Asn 
1               5                   10                  15      


Ser Tyr Tyr Gln Pro Asp Met Glu Tyr Ser Glu Ile Val Gly Leu Pro 
            20                  25                  30          


Glu Glu Glu Glu Ile Pro Ala Asn Arg Lys Ile Lys Phe Ser Xaa Ala 
        35                  40                  45              


Pro Ile Lys Val Phe Asn Thr Tyr Ser Asn Glu Asp Tyr Asp Arg Arg 
    50                  55                  60                  


Asn 
65  


<210>  223
<211>  51
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<400>  223

Ile Gln Phe Thr Val Pro Leu Leu Glu Pro His Leu Asp Pro Glu Ala 
1               5                   10                  15      


Ala Glu Gln Ile Arg Arg Arg Arg Pro Xaa Pro Ala Thr Leu Val Leu 
            20                  25                  30          


Thr Ser Asp Gln Ser Ser Pro Glu Ile Asp Glu Asp Arg Ile Pro Asn 
        35                  40                  45              


Pro His Leu 
    50      


<210>  224
<211>  145
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  224

Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His 
1               5                   10                  15      


Ile Asn Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val 
            20                  25                  30          


Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala 
        35                  40                  45              


Arg Tyr Asp Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His 
    50                  55                  60                  


Ala Ala Ala His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Glu 
65                  70                  75                  80  


Asn Leu Cys Asp Met Glu Ala Val Asn Lys Val Gly Gln Thr Ala Phe 
                85                  90                  95      


Asp Val Ala Asp Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys Arg 
            100                 105                 110         


His Ala Arg Thr Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg Leu 
        115                 120                 125             


Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg Glu 
    130                 135                 140                 


Ala 
145 


<210>  225
<211>  435
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  225
gagagaatca tgctgagaga tgctaggcaa tggctcaact ccggccatat caatgacgtc       60

aggcacgcca aaagcggagg cacagccctc cacgtcgccg ctgccaaagg ctataccgaa      120

gtgctcaagc tcctgattca ggctaggtat gacgtcaaca ttaaggatta cgatggctgg      180

acccctctgc acgccgctgc ccattgggga aaggaagaag cttgcagaat cctcgtggaa      240

aacctctgcg atatggaagc cgtcaacaaa gtgggacaga cagcctttga cgtcgccgat      300

ggccctggcg gaagccctgg cggactgcaa aagagacacg ctaggacagt gaaatacgat      360

aggagagagc tgcagagaag gctcgacgtc gagaaatgga ttgacggaag gctcgaagaa      420

ctgtataggg aagcc                                                       435


<210>  226
<211>  503
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  226
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccggcgag agaatcatgc       60

tgagagatgc taggcaatgg ctcaactccg gccatatcaa tgacgtcagg cacgccaaaa      120

gcggaggcac agccctccac gtcgccgctg ccaaaggcta taccgaagtg ctcaagctcc      180

tgattcaggc taggtatgac gtcaacatta aggattacga tggctggacc cctctgcacg      240

ccgctgccca ttggggaaag gaagaagctt gcagaatcct cgtggaaaac ctctgcgata      300

tggaagccgt caacaaagtg ggacagacag cctttgacgt cgccgatggc cctggcggaa      360

gccctggcgg actgcaaaag agacacgcta ggacagtgaa atacgatagg agagagctgc      420

agagaaggct cgacgtcgag aaatggattg acggaaggct cgaagaactg tatagggaag      480

cccccggggg aggcggaatc gat                                              503


<210>  227
<211>  125
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  227

Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile Gly 
1               5                   10                  15      


Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr Lys 
            20                  25                  30          


Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ser Ser Gly 
        35                  40                  45              


Asp Thr Glu Glu Val Leu Arg Leu Leu Glu Arg Gly Ala Asp Ile Asn 
    50                  55                  60                  


Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala Cys Ile Asp 
65                  70                  75                  80  


Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys Arg His Ala Arg Thr 
                85                  90                  95      


Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg Leu Asp Val Glu Lys 
            100                 105                 110         


Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg Glu Ala 
        115                 120                 125 


<210>  228
<211>  375
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  228
gccgatgcca aacagaaaag gaatgagcaa ctgaaaaggt ggatcggaag cgaaaccgat       60

ctggaacccc ctgtggtcaa gagaaagaaa accaaagtga aattcgatga cggagccgtc      120

ttcctcgccg cttgctccag cggagacaca gaggaagtgc tcaggctcct ggaaagggga      180

gccgatatta attacgctaa cgtcgatgga ctgacagccc tccaccaagc ctgtatcgac      240

ggccctggcg gaagccctgg cggactgcaa aagagacacg ctaggacagt gaaatacgat      300

aggagagagc tgcagagaag gctcgacgtc gagaaatgga ttgacggaag gctcgaagaa      360

ctgtataggg aagcc                                                       375


<210>  229
<211>  443
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  229
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccggcgcc gatgccaaac       60

agaaaaggaa tgagcaactg aaaaggtgga tcggaagcga aaccgatctg gaaccccctg      120

tggtcaagag aaagaaaacc aaagtgaaat tcgatgacgg agccgtcttc ctcgccgctt      180

gctccagcgg agacacagag gaagtgctca ggctcctgga aaggggagcc gatattaatt      240

acgctaacgt cgatggactg acagccctcc accaagcctg tatcgacggc cctggcggaa      300

gccctggcgg actgcaaaag agacacgcta ggacagtgaa atacgatagg agagagctgc      360

agagaaggct cgacgtcgag aaatggattg acggaaggct cgaagaactg tatagggaag      420

cccccggggg aggcggaatc gat                                              443


<210>  230
<211>  70
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  230

Ala Arg Val Thr Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg Leu 
1               5                   10                  15      


Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg Glu 
            20                  25                  30          


Ala Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp 
        35                  40                  45              


Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys 
    50                  55                  60                  


Thr Lys Val Lys Phe Asp 
65                  70  


<210>  231
<211>  210
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  231
gccagagtga cagtgaaata cgataggaga gagctgcaga gaaggctcga cgtcgagaaa       60

tggattgacg gaaggctcga agaactgtat agggaagcca tggccgatgc caaacagaaa      120

aggaatgagc aactgaaaag gtggatcgga agcgaaaccg atctggaacc ccctgtggtc      180

aagagaaaga aaaccaaagt gaaattcgac                                       210


<210>  232
<211>  257
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  232
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccagagtg acagtgaaat       60

acgataggag agagctgcag agaaggctcg acgtcgagaa atggattgac ggaaggctcg      120

aagaactgta tagggaagcc atggccgatg ccaaacagaa aaggaatgag caactgaaaa      180

ggtggatcgg aagcgaaacc gatctggaac cccctgtggt caagagaaag aaaaccaaag      240

tgaaattcga catcgat                                                     257


<210>  233
<211>  82
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  233

Ala Arg Val Thr Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg Leu 
1               5                   10                  15      


Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg Glu 
            20                  25                  30          


Ala Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp 
        35                  40                  45              


Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys 
    50                  55                  60                  


Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ser 
65                  70                  75                  80  


Ser Gly 
        


<210>  234
<211>  246
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  234
gccagagtga cagtgaaata cgataggaga gagctgcaga gaaggctcga cgtcgagaaa       60

tggattgacg gaaggctcga agaactgtat agggaagcca tggccgatgc caaacagaaa      120

aggaatgagc aactgaaaag gtggatcgga agcgaaaccg atctggaacc ccctgtggtc      180

aagagaaaga aaaccaaagt gaaattcgat gacggagccg tcttcctcgc cgcttgctcc      240

agcgga                                                                 246


<210>  235
<211>  293
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  235
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccagagtg acagtgaaat       60

acgataggag agagctgcag agaaggctcg acgtcgagaa atggattgac ggaaggctcg      120

aagaactgta tagggaagcc atggccgatg ccaaacagaa aaggaatgag caactgaaaa      180

ggtggatcgg aagcgaaacc gatctggaac cccctgtggt caagagaaag aaaaccaaag      240

tgaaattcga tgacggagcc gtcttcctcg ccgcttgctc cagcggaatc gat             293


<210>  236
<211>  107
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  236

Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile Gly 
1               5                   10                  15      


Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr Lys 
            20                  25                  30          


Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ser Ser Gly 
        35                  40                  45              


Asp Thr Glu Glu Val Leu Arg Leu Leu Glu Arg Gly Ala Asp Ile Asn 
    50                  55                  60                  


Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala Cys Ile Asp 
65                  70                  75                  80  


Gly Pro Gly Gly Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg 
                85                  90                  95      


Pro Thr Pro Ala Thr Leu Val Ser Pro Gly Gly 
            100                 105         


<210>  237
<211>  321
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  237
gccgatgcca aacagaaaag gaatgagcaa ctgaaaaggt ggatcggaag cgaaaccgat       60

ctggaacccc ctgtggtcaa gagaaagaaa accaaagtga aattcgatga cggagccgtc      120

ttcctcgccg cttgctccag cggagacaca gaggaagtgc tcaggctcct ggaaagggga      180

gccgatatta attacgctaa cgtcgatgga ctgacagccc tccaccaagc ctgtatcgac      240

ggccctggcg gagaccctga ggctgccgaa cagattagga gaaggagacc cacacccgct      300

accctcgtgt cccccggagg c                                                321


<210>  238
<211>  368
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  238
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccgatgcc aaacagaaaa       60

ggaatgagca actgaaaagg tggatcggaa gcgaaaccga tctggaaccc cctgtggtca      120

agagaaagaa aaccaaagtg aaattcgatg acggagccgt cttcctcgcc gcttgctcca      180

gcggagacac agaggaagtg ctcaggctcc tggaaagggg agccgatatt aattacgcta      240

acgtcgatgg actgacagcc ctccaccaag cctgtatcga cggccctggc ggagaccctg      300

aggctgccga acagattagg agaaggagac ccacacccgc taccctcgtg tcccccggag      360

gcatcgat                                                               368


<210>  239
<211>  80
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  239

Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile Gly 
1               5                   10                  15      


Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr Lys 
            20                  25                  30          


Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ala Leu His 
        35                  40                  45              


Gln Ala Cys Ile Asp Gly Pro Gly Gly Asp Pro Glu Ala Ala Glu Gln 
    50                  55                  60                  


Ile Arg Arg Arg Arg Pro Thr Pro Ala Thr Leu Val Ser Pro Gly Gly 
65                  70                  75                  80  


<210>  240
<211>  240
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  240
gccgatgcca aacagaaaag gaatgagcaa ctgaaaaggt ggatcggaag cgaaaccgat       60

ctggaacccc ctgtggtcaa gagaaagaaa accaaagtga aattcgatga cggagccgtc      120

ttcctcgccg cttgcgctct gcatcaggct tgcattgacg gacccggagg cgatcccgaa      180

gccgctgaac aaatcagaag gagaaggccc acccctgcca cactggtcag ccctggcgga      240


<210>  241
<211>  287
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  241
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccgatgcc aaacagaaaa       60

ggaatgagca actgaaaagg tggatcggaa gcgaaaccga tctggaaccc cctgtggtca      120

agagaaagaa aaccaaagtg aaattcgatg acggagccgt cttcctcgcc gcttgcgctc      180

tgcatcaggc ttgcattgac ggacccggag gcgatcccga agccgctgaa caaatcagaa      240

ggagaaggcc cacccctgcc acactggtca gccctggcgg aatcgat                    287


<210>  242
<211>  145
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  242

Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His 
1               5                   10                  15      


Ile Asn Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val 
            20                  25                  30          


Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala 
        35                  40                  45              


Arg Tyr Asp Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His 
    50                  55                  60                  


Ala Ala Ala His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Glu 
65                  70                  75                  80  


Asn Leu Cys Asp Met Glu Ala Val Asn Lys Val Gly Gln Thr Ala Phe 
                85                  90                  95      


Asp Val Ala Asp Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys Arg 
            100                 105                 110         


His Ala Arg Asp Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg Leu 
        115                 120                 125             


Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg Glu 
    130                 135                 140                 


Ala 
145 


<210>  243
<211>  435
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  243
gagagaatca tgctgagaga tgctaggcaa tggctcaact ccggccatat caatgacgtc       60

aggcacgcca aaagcggagg cacagccctc cacgtcgccg ctgccaaagg ctataccgaa      120

gtgctcaagc tcctgattca ggctaggtat gacgtcaaca ttaaggatta cgatggctgg      180

acccctctgc acgccgctgc ccattgggga aaggaagaag cttgcagaat cctcgtggaa      240

aacctctgcg atatggaagc cgtcaacaaa gtgggacaga cagcctttga cgtcgccgat      300

ggccctggcg gaagccctgg cggactgcaa aagagacacg ctagggatgt gaaatacgat      360

aggagagagc tgcagagaag gctcgacgtc gagaaatgga ttgacggaag gctcgaagaa      420

ctgtataggg aagcc                                                       435


<210>  244
<211>  503
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  244
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccggcgag agaatcatgc       60

tgagagatgc taggcaatgg ctcaactccg gccatatcaa tgacgtcagg cacgccaaaa      120

gcggaggcac agccctccac gtcgccgctg ccaaaggcta taccgaagtg ctcaagctcc      180

tgattcaggc taggtatgac gtcaacatta aggattacga tggctggacc cctctgcacg      240

ccgctgccca ttggggaaag gaagaagctt gcagaatcct cgtggaaaac ctctgcgata      300

tggaagccgt caacaaagtg ggacagacag cctttgacgt cgccgatggc cctggcggaa      360

gccctggcgg actgcaaaag agacacgcta gggatgtgaa atacgatagg agagagctgc      420

agagaaggct cgacgtcgag aaatggattg acggaaggct cgaagaactg tatagggaag      480

cccccggggg aggcggaatc gat                                              503


<210>  245
<211>  82
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  245

Ala Arg Val Asp Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg Arg Leu 
1               5                   10                  15      


Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr Arg Glu 
            20                  25                  30          


Ala Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp 
        35                  40                  45              


Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys 
    50                  55                  60                  


Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ser 
65                  70                  75                  80  


Ser Gly 
        


<210>  246
<211>  246
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  246
gccagagtgg atgtgaaata cgataggaga gagctgcaga gaaggctcga cgtcgagaaa       60

tggattgacg gaaggctcga agaactgtat agggaagcca tggccgatgc caaacagaaa      120

aggaatgagc aactgaaaag gtggatcgga agcgaaaccg atctggaacc ccctgtggtc      180

aagagaaaga aaaccaaagt gaaattcgat gacggagccg tcttcctcgc cgcttgctcc      240

agcgga                                                                 246


<210>  247
<211>  293
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  247
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccagagtg gatgtgaaat       60

acgataggag agagctgcag agaaggctcg acgtcgagaa atggattgac ggaaggctcg      120

aagaactgta tagggaagcc atggccgatg ccaaacagaa aaggaatgag caactgaaaa      180

ggtggatcgg aagcgaaacc gatctggaac cccctgtggt caagagaaag aaaaccaaag      240

tgaaattcga tgacggagcc gtcttcctcg ccgcttgctc cagcggaatc gat             293


<210>  248
<211>  80
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  248

Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile Gly 
1               5                   10                  15      


Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr Lys 
            20                  25                  30          


Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ala Leu His 
        35                  40                  45              


Gln Ala Cys Ile Asp Gly Pro Gly Gly Asp Pro Glu Ala Ala Glu Gln 
    50                  55                  60                  


Ile Arg Arg Arg Arg Pro Asp Pro Ala Asp Leu Val Ser Pro Gly Gly 
65                  70                  75                  80  


<210>  249
<211>  240
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  249
gccgatgcca aacagaaaag gaatgagcaa ctgaaaaggt ggatcggaag cgaaaccgat       60

ctggaacccc ctgtggtcaa gagaaagaaa accaaagtga aattcgatga cggagccgtc      120

ttcctcgccg cttgcgctct gcatcaggct tgcattgacg gacccggagg cgatcccgaa      180

gccgctgaac aaatcagaag gagaaggccc gaccctgccg atctggtcag ccctggcgga      240


<210>  250
<211>  287
<212>  DNA
<213>  artificial sequence

<220>
<223>  synthetic

<400>  250
ggcgcgccac gcgtgggggg gggggggcta gcgccaccat ggccgatgcc aaacagaaaa       60

ggaatgagca actgaaaagg tggatcggaa gcgaaaccga tctggaaccc cctgtggtca      120

agagaaagaa aaccaaagtg aaattcgatg acggagccgt cttcctcgcc gcttgcgctc      180

tgcatcaggc ttgcattgac ggacccggag gcgatcccga agccgctgaa caaatcagaa      240

ggagaaggcc cgaccctgcc gatctggtca gccctggcgg aatcgat                    287


<210>  251
<211>  100
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  251

Glu Arg Ile Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His 
1               5                   10                  15      


Ile Asn Asp Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val 
            20                  25                  30          


Ala Ala Ala Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala 
        35                  40                  45              


Arg Tyr Asp Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His 
    50                  55                  60                  


Ala Ala Ala His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Glu 
65                  70                  75                  80  


Asn Leu Cys Asp Met Glu Ala Val Asn Lys Val Gly Gln Thr Ala Phe 
                85                  90                  95      


Asp Val Ala Asp 
            100 


<210>  252
<211>  80
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  252

Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile Gly 
1               5                   10                  15      


Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr Lys 
            20                  25                  30          


Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ser Ser Gly 
        35                  40                  45              


Asp Thr Glu Glu Val Leu Arg Leu Leu Glu Arg Gly Ala Asp Ile Asn 
    50                  55                  60                  


Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala Cys Ile Asp 
65                  70                  75                  80  


<210>  253
<211>  37
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  253

Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile 
1               5                   10                  15      


Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr 
            20                  25                  30          


Lys Val Lys Phe Asp 
        35          


<210>  254
<211>  49
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  254

Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile 
1               5                   10                  15      


Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr 
            20                  25                  30          


Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ser Ser 
        35                  40                  45              


Gly 
    


<210>  255
<211>  53
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  255

Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg Trp Ile Gly 
1               5                   10                  15      


Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys Lys Thr Lys 
            20                  25                  30          


Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys Ala Leu His 
        35                  40                  45              


Gln Ala Cys Ile Asp 
    50              


<210>  256
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  256

Leu Gln Lys Arg His Ala Arg Thr Val Lys Tyr Asp Arg Arg Glu Leu 
1               5                   10                  15      


Gln 
    


<210>  257
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  257

Ala Arg Val Thr Val Lys Tyr Asp Arg Arg Glu Leu Gln 
1               5                   10              


<210>  258
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  258

Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg Pro Thr Pro Ala 
1               5                   10                  15      


Thr Leu Val 
            


<210>  259
<211>  17
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  259

Leu Gln Lys Arg His Ala Arg Asp Val Lys Tyr Asp Arg Arg Glu Leu 
1               5                   10                  15      


Gln 
    


<210>  260
<211>  13
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  260

Ala Arg Val Asp Val Lys Tyr Asp Arg Arg Glu Leu Gln 
1               5                   10              


<210>  261
<211>  19
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  261

Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg Pro Asp Pro Ala 
1               5                   10                  15      


Asp Leu Val 
            


<210>  262
<211>  20
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  262

Arg Arg Leu Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu 
1               5                   10                  15      


Tyr Arg Glu Ala 
            20  


<210>  263
<211>  8
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  263

Gly Pro Gly Gly Ser Pro Gly Gly 
1               5               


<210>  264
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  264

Gly Pro Gly Gly 
1               


<210>  265
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  synthetic

<400>  265

Ser Pro Gly Gly 
1               


<210>  266
<211>  1004
<212>  PRT
<213>  Gallus gallus

<400>  266

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
1               5                   10                  15      


Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Lys 
            20                  25                  30          


Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
        35                  40                  45              


Ser Ser Gly Asp Thr Glu Glu Val Leu Arg Leu Leu Glu Arg Gly Ala 
    50                  55                  60                  


Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
65                  70                  75                  80  


Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                85                  90                  95      


Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
            100                 105                 110         


Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Tyr Leu Ile Ser Gln 
        115                 120                 125             


Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
    130                 135                 140                 


Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
145                 150                 155                 160 


Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                165                 170                 175     


Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
            180                 185                 190         


Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
        195                 200                 205             


Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Arg Tyr Asp 
    210                 215                 220                 


Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
225                 230                 235                 240 


His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Glu Asn Leu Cys 
                245                 250                 255     


Asp Met Glu Ala Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
            260                 265                 270         


Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
        275                 280                 285             


Leu Leu His Ser Glu Lys Arg Glu Lys Lys Ser Pro Leu Ile Glu Ser 
    290                 295                 300                 


Thr Ala Asn Leu Asp Asn Asn Gln Thr Gln Lys Thr Phe Lys Asn Lys 
305                 310                 315                 320 


Glu Thr Leu Ile Met Glu Gln Glu Lys Asn Ala Ser Ser Ile Glu Ser 
                325                 330                 335     


Leu Glu His Glu Lys Ala Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
            340                 345                 350         


Ser Ser Cys Ser Ser Glu Glu Glu Glu Asp Asp Asp Ser Glu Ser Glu 
        355                 360                 365             


Ala Glu Thr Asp Lys Ala Lys Thr Leu Ala Asn Ala Asn Thr Thr Ser 
    370                 375                 380                 


Thr Gln Ser Ala Ser Met Thr Ala Pro Ser Val Ala Gly Gly Gln Gly 
385                 390                 395                 400 


Thr Pro Thr Ser Pro Leu Lys Lys Phe Pro Thr Ser Thr Thr Lys Val 
                405                 410                 415     


Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser Pro Ala Ser Trp Arg 
            420                 425                 430         


Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala Leu Ala Glu Ile Thr 
        435                 440                 445             


Ala Ser Lys Glu Ala Gln Lys Glu Lys Asp Ser Ala Gly Val Ile Arg 
    450                 455                 460                 


Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu Asp Asn Lys Glu Lys 
465                 470                 475                 480 


Glu Lys Asp Gly Lys Gly Thr Arg Leu Ala Tyr Val Ala Pro Thr Ile 
                485                 490                 495     


Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Asp Glu Lys Glu Asn Arg 
            500                 505                 510         


Asp Ser Ser Ala Ser Ser Ile Arg Ser Gly Ser Ser Tyr Ala Arg Arg 
        515                 520                 525             


Lys Trp Glu Glu Asp Val Lys Lys Asn Ser Leu Asn Glu Gly Pro Thr 
    530                 535                 540                 


Ser Leu Asn Thr Ser Tyr Gln Arg Ser Gly Ser Phe Gly Arg Arg Gln 
545                 550                 555                 560 


Asp Asp Leu Val Ser Ser Asn Val Pro Ser Thr Ala Ser Thr Val Thr 
                565                 570                 575     


Ser Ser Ala Gly Leu Gln Lys Thr Leu Pro Ala Ser Ala Asn Thr Thr 
            580                 585                 590         


Thr Lys Ser Thr Thr Gly Ser Thr Ser Ala Gly Val Gln Ser Ser Thr 
        595                 600                 605             


Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp Ser 
    610                 615                 620                 


Val Pro Thr Ala Val Thr Val Pro Val Ala Pro Ser Val Val Asn Ala 
625                 630                 635                 640 


Ala Ala Thr Thr Thr Ala Met Thr Thr Ala Thr Ser Gly Thr Val Ser 
                645                 650                 655     


Ser Thr Ser Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro Val 
            660                 665                 670         


Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln Ala 
        675                 680                 685             


Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu Gln 
    690                 695                 700                 


Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg Glu 
705                 710                 715                 720 


Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp Lys 
                725                 730                 735     


Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Lys Asp Asp Asp Tyr 
            740                 745                 750         


Arg Gln Arg Tyr Ser Arg Thr Val Glu Glu Pro Tyr His Arg Tyr Arg 
        755                 760                 765             


Pro Thr Ser Thr Ser Thr Ser Thr Ser Ser Thr Ser Ser Leu Ser Thr 
    770                 775                 780                 


Ser Thr Ser Ser Leu Ser Ser Ser Ser Gln Leu Asn Arg Pro Asn Ser 
785                 790                 795                 800 


Leu Ile Gly Ile Thr Ser Ala Tyr Ser Arg Ser Gly Thr Lys Glu Ser 
                805                 810                 815     


Glu Arg Glu Gly Gly Lys Lys Glu Glu Glu Lys Glu Glu Asp Lys Ser 
            820                 825                 830         


Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu Lys Arg Arg 
        835                 840                 845             


Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu Asn Glu Gln 
    850                 855                 860                 


Glu His Gln Ser Asp Ser Glu Glu Gly Thr Asn Lys Lys Glu Thr Gln 
865                 870                 875                 880 


Ser Asp Ser Leu Ser Arg Tyr Asp Thr Gly Ser Leu Ser Val Ser Ser 
                885                 890                 895     


Gly Asp Arg Tyr Asp Ser Ala Gln Gly Arg Ser Gly Ser Gln Ser Tyr 
            900                 905                 910         


Leu Glu Asp Arg Lys Pro Tyr Cys Ser Arg Leu Glu Lys Glu Asp Ser 
        915                 920                 925             


Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu Lys 
    930                 935                 940                 


Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu Lys 
945                 950                 955                 960 


Leu Gln Leu Glu Lys Thr Thr Gln Arg Gln Glu Arg Phe Ala Asp Arg 
                965                 970                 975     


Ser Leu Leu Glu Met Glu Lys Arg Val Ser Gly Lys Ser Gln Tyr Leu 
            980                 985                 990         


Leu Gly Gly Lys Lys Ser Ser Arg  Lys Lys Asp Ile 
        995                 1000                 


<210>  267
<211>  147
<212>  PRT
<213>  Homo sapiens

<400>  267

Met Ala Ala Gln Arg Leu Gly Lys Arg Val Leu Ser Lys Leu Gln Ser 
1               5                   10                  15      


Pro Ser Arg Ala Arg Gly Pro Gly Gly Ser Pro Gly Gly Leu Gln Lys 
            20                  25                  30          


Arg His Ala Arg Val Thr Val Lys Tyr Asp Arg Arg Glu Leu Gln Arg 
        35                  40                  45              


Arg Leu Asp Val Glu Lys Trp Ile Asp Gly Arg Leu Glu Glu Leu Tyr 
    50                  55                  60                  


Arg Gly Met Glu Ala Asp Met Pro Asp Glu Ile Asn Ile Asp Glu Leu 
65                  70                  75                  80  


Leu Glu Leu Glu Ser Glu Glu Glu Arg Ser Arg Lys Ile Gln Gly Leu 
                85                  90                  95      


Leu Lys Ser Cys Gly Lys Pro Val Glu Asp Phe Ile Gln Glu Leu Leu 
            100                 105                 110         


Ala Lys Leu Gln Gly Leu His Arg Gln Pro Gly Leu Arg Gln Pro Ser 
        115                 120                 125             


Pro Ser His Asp Gly Ser Leu Ser Pro Leu Gln Asp Arg Ala Arg Thr 
    130                 135                 140                 


Ala His Pro 
145         


<210>  268
<211>  185
<212>  PRT
<213>  Xenopus laevis

<400>  268

Met Glu Ala Asn Ser Pro Arg Lys Ile Gln Phe Thr Val Pro Phe Leu 
1               5                   10                  15      


Glu Pro His Leu Asp Pro Glu Ala Ala Glu Gln Ile Arg Arg Arg Arg 
            20                  25                  30          


Pro Thr Pro Ala Thr Leu Val Leu Ser Ser Asp Gln Ser Ser Pro Glu 
        35                  40                  45              


Ile Asp Glu Glu Arg Val Pro Asn Pro Leu Gln Lys Ser Leu Ser Met 
    50                  55                  60                  


Ser Pro His Gln Arg Lys Lys Met Ser Arg Ile Thr Pro Thr Met Lys 
65                  70                  75                  80  


Glu Leu Gln Leu Leu Ala Glu His His Leu Cys Lys Gln Gly Ser Glu 
                85                  90                  95      


Glu Glu Lys Ile Pro His Leu Gln Asn Asn Leu Asp Asp Arg Pro Asp 
            100                 105                 110         


Leu Gly Cys Cys Cys His Gly Asn Thr Ala Ser Thr Gln Ala Ser Gln 
        115                 120                 125             


Ser His Ile Pro Cys Ser Cys Phe Thr Gln Asp Gly Gln His Asp Thr 
    130                 135                 140                 


Asn Ser Leu Gly Ser Arg His Ser Ser Lys Glu Asp Ser Leu Asp Ser 
145                 150                 155                 160 


His Val Ser Asp Gly Asn Met Gln Ile Cys Glu Pro Lys Lys Gln Asn 
                165                 170                 175     


Ser His Ile Ser Phe Ile Glu Asp Lys 
            180                 185 


