                         SEQUENCE LISTING

<110>  MedImmune
       Mao, Su-Yao
       Chen, Bo
       Chang, Chew-Shun
       Tian, Jane
       Chowdhury, Partha
       Coyle, Anthony
       Sims, Gary
 
<120>  Anti-RAGE Antibodies and Methods of Use Thereof

<130>  RG100PCT

<150>  US 60/915,578
<151>  2007-05-02

<150>  US 60/946,784
<151>  2007-06-28

<150>  US 60/984,054
<151>  2007-10-31

<160>  15    

<170>  PatentIn version 3.3

<210>  1
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  2
<211>  402
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Met Pro Thr Gly Thr Val Ala Arg Ala Trp Val Leu Val Leu Ala Leu 
1               5                   10                  15      


Trp Gly Ala Val Ala Gly Gly Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Met Leu Ser Cys Lys Gly Ala Pro Lys Lys Pro Thr Gln Lys 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Asp Pro Trp Asp Ser Val Ala Arg Ile Leu Pro Asn 
65                  70                  75                  80  


Gly Ser Leu Leu Leu Pro Ala Ile Gly Ile Val Asp Glu Gly Thr Phe 
                85                  90                  95      


Arg Cys Arg Ala Thr Asn Arg Leu Gly Lys Glu Val Lys Ser Asn Tyr 
            100                 105                 110         


Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asn Pro 
        115                 120                 125             


Ala Ser Glu Leu Thr Ala Asn Val Pro Asn Lys Val Gly Thr Cys Val 
    130                 135                 140                 


Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly 
145                 150                 155                 160 


Lys Pro Leu Ile Pro Asp Gly Lys Gly Thr Val Val Lys Glu Glu Thr 
                165                 170                 175     


Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Arg Ser Glu Leu Thr 
            180                 185                 190         


Val Thr Pro Ala Gln Gly Gly Thr Thr Pro Thr Tyr Ser Cys Ser Phe 
        195                 200                 205             


Ser Leu Gly Leu Pro Arg Arg Arg Pro Leu Asn Thr Ala Pro Ile Gln 
    210                 215                 220                 


Pro Arg Val Arg Glu Pro Leu Pro Pro Glu Gly Ile Gln Leu Leu Val 
225                 230                 235                 240 


Glu Pro Glu Gly Gly Thr Val Ala Pro Gly Gly Thr Val Thr Leu Thr 
                245                 250                 255     


Cys Ala Ile Ser Ala Gln Pro Pro Pro Gln Ile His Trp Ile Lys Asp 
            260                 265                 270         


Gly Thr Pro Leu Pro Leu Ala Pro Ser Pro Val Leu Leu Leu Pro Glu 
        275                 280                 285             


Val Gly His Glu Asp Glu Gly Ile Tyr Ser Cys Val Ala Thr His Pro 
    290                 295                 300                 


Ser His Gly Pro Gln Glu Ser Pro Pro Val Asn Ile Arg Val Thr Glu 
305                 310                 315                 320 


Thr Gly Asp Glu Gly Gln Ala Ala Gly Ser Val Asp Gly Ser Gly Leu 
                325                 330                 335     


Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly Ile Ala 
            340                 345                 350         


Ala Leu Leu Ile Gly Ala Ile Leu Trp Arg Lys Arg Gln Pro Arg Leu 
        355                 360                 365             


Glu Glu Arg Lys Ala Pro Glu Ser Gln Glu Asp Glu Glu Glu Arg Ala 
    370                 375                 380                 


Glu Leu Asn Gln Ser Glu Glu Ala Glu Met Pro Glu Asn Gly Ala Gly 
385                 390                 395                 400 


Gly Pro 
        


<210>  3
<211>  416
<212>  PRT
<213>  Bos taurus

<400>  3

Met Ala Ala Gly Ala Val Val Gly Ala Trp Met Leu Val Leu Ser Leu 
1               5                   10                  15      


Gly Gly Thr Val Thr Gly Asp Gln Asn Ile Thr Ala Arg Ile Gly Lys 
            20                  25                  30          


Pro Leu Val Leu Asn Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Gln 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Asp Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn 
65                  70                  75                  80  


Gly Ser Leu Leu Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Thr Phe 
                85                  90                  95      


Arg Cys Arg Ala Thr Ser Arg Ser Gly Lys Glu Thr Lys Ser Asn Tyr 
            100                 105                 110         


Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Pro 
        115                 120                 125             


Ala Ser Glu Leu Met Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val 
    130                 135                 140                 


Ser Glu Gly Gly Tyr Pro Ala Gly Thr Leu Asn Trp Leu Leu Asp Gly 
145                 150                 155                 160 


Lys Thr Leu Ile Pro Asp Gly Lys Gly Val Ser Val Lys Glu Glu Thr 
                165                 170                 175     


Lys Arg His Pro Lys Thr Gly Leu Phe Thr Leu His Ser Glu Leu Met 
            180                 185                 190         


Val Thr Pro Ala Arg Gly Gly Ala Leu His Pro Thr Phe Ser Cys Ser 
        195                 200                 205             


Phe Thr Pro Gly Leu Pro Arg Arg Arg Ala Leu His Thr Ala Pro Ile 
    210                 215                 220                 


Gln Leu Arg Val Trp Ser Glu His Arg Gly Gly Glu Gly Pro Asn Val 
225                 230                 235                 240 


Asp Ala Val Pro Leu Lys Glu Val Gln Leu Val Val Glu Pro Glu Gly 
                245                 250                 255     


Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Ala Pro 
            260                 265                 270         


Ala Gln Pro Pro Pro Gln Ile His Trp Ile Lys Asp Gly Arg Pro Leu 
        275                 280                 285             


Pro Leu Pro Pro Gly Pro Met Leu Leu Leu Pro Glu Val Gly Pro Glu 
    290                 295                 300                 


Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Pro Ser His Gly Pro 
305                 310                 315                 320 


Gln Glu Ser Arg Ala Val Ser Val Thr Ile Ile Glu Thr Gly Glu Glu 
                325                 330                 335     


Gly Thr Thr Ala Gly Ser Val Glu Gly Pro Gly Leu Glu Thr Leu Ala 
            340                 345                 350         


Leu Thr Leu Gly Ile Leu Gly Gly Leu Gly Thr Val Ala Leu Leu Ile 
        355                 360                 365             


Gly Val Ile Val Trp His Arg Arg Arg Gln Arg Lys Gly Gln Glu Arg 
    370                 375                 380                 


Lys Val Pro Glu Asn Gln Glu Glu Glu Glu Glu Glu Arg Ala Glu Leu 
385                 390                 395                 400 


Asn Gln Pro Glu Glu Pro Glu Ala Ala Glu Ser Ser Thr Gly Gly Pro 
                405                 410                 415     


<210>  4
<211>  113
<212>  PRT
<213>  mus musculus

<400>  4

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  5
<211>  122
<212>  PRT
<213>  mus musculus

<400>  5

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Ile Ser Cys Lys Thr Ser Glu Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Lys Leu Gly Thr Thr Val Val Ala Pro Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  6
<211>  113
<212>  PRT
<213>  mus musculus

<400>  6

Asp Ile Val Met Ser Gln Ser Pro Ser Ser Leu Ala Val Ser Ala Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser Leu Leu Tyr Ser 
            20                  25                  30          


Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Ser Gly Gln 
        35                  40                  45              


Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg Glu Ser Gly Val 
    50                  55                  60                  


Pro Asp Arg Phe Thr Gly Gly Gly Ser Gly Thr Asp Phe Thr Leu Thr 
65                  70                  75                  80  


Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr Tyr Cys Lys Gln 
                85                  90                  95      


Ser Tyr Asn Leu Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  7
<211>  122
<212>  PRT
<213>  mus musculus

<400>  7

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Gln Ile Ser Cys Lys Thr Ser Glu Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Ser His Gly Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Gly Gly Thr Ala Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Asp Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ser Arg Ser Lys Leu Gly Thr Thr Val Val Ala Pro Tyr Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  8
<211>  108
<212>  PRT
<213>  mus musculus

<400>  8

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Thr Ala Cys Lys Ala Ser Gln Asp Ile Asn Thr Tyr 
            20                  25                  30          


Leu Ser Trp Phe Gln Gln Lys Pro Gly Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Tyr Arg Ala Asn Arg Leu Val Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Arg Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Tyr 
65                  70                  75                  80  


Glu Asp Met Gly Ile Tyr Tyr Cys Leu Gln Tyr Asp Glu Phe Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Thr Leu Glu Ile Lys Arg 
            100                 105             


<210>  9
<211>  113
<212>  PRT
<213>  mus musculus

<400>  9

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Thr Ser Gly Tyr Thr Phe Thr Glu Tyr 
            20                  25                  30          


Asn Met Tyr Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Gly Ile Asn Pro Asn Asn Cys Asp Thr Thr Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Gly Leu Val Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
            100                 105                 110         


Ala 
    


<210>  10
<211>  321
<212>  DNA
<213>  Mus musculus

<400>  10
gaaaatgtgc tcacccagtc tccagcaatc atgtctgcat ctctagggga gaaggtcacc     60

atgagctgca gggccagttc aagtgtaaat tacatgtact ggtaccagca gaagtcagat    120

gcctccccca aactatggat ttattacaca tccaacctgg ctcctggagt cccagctcgc    180

ttcagtggca gtgggtctgg gaactcttat tctctcacaa tcagcagcat ggagggtgaa    240

gatgctgcca cttattactg ccagcagttt actagttccc catccacgtt cggtcctggg    300

accaagctgg agctgaaacg g                                              321


<210>  11
<211>  354
<212>  DNA
<213>  mus musculus

<400>  11
caggtccagc tgcaccagtc tggagctgag ctggtaaggc ctgggacttc agtgaaggtg     60

tcctgcaagg cttctggata cgccttcact cattacttga tagagtgggt aaagcagagg    120

cctgggcagg gccttgagtg gattggagtg attaatcctg gaagtggtag tactaactat    180

aatgagaagt tcaaggacaa ggcaacactg actgcagaca aatcctccag cactgcctac    240

atgcagctca gtagcctgac atctgatgac tctgcggtct atttctgtgc aagaaggaag    300

gtctatgatg gttacgatgt ctggggcgca gggaccacgg tcgccgtctc ctca          354


<210>  12
<211>  339
<212>  DNA
<213>  mus musculus

<400>  12
gacattgtga tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact     60

atgagctgca aatccagtca gagtctgctc tacagtagaa cccgaaagaa ctacttggct    120

tggtaccagc agaaatcagg gcagtctcct aaactgctga tctactgggc atccactagg    180

gaatctgggg tccctgatcg cttcacaggc ggtggatctg ggacagattt cactctcacc    240

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctt    300

ccgacgttcg gtggaggcac caagctggaa atcaaacgg                           339


<210>  13
<211>  366
<212>  DNA
<213>  mus musculus

<400>  13
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgcagata     60

tcctgcaaga cttctgaata cacattcact gaatacacca tgcactgggt gaagcagagc    120

catggaaaga gccttgagtg gattggaggt attaatccta acaatggtgg tactgcctac    180

aaccagaagt tcaaggacaa ggccacattg actgtagaca agtcctccag cacagcctac    240

atggagctcc gcagcctgac atctgatgat tctgccgtct attactgttc aagatcaaag    300

ttgggtacta cggtagtggc cccctatgac tactggggtc aaggaacctc agtcaccgtc    360

tcctca                                                               366


<210>  14
<211>  324
<212>  DNA
<213>  mus musculus

<400>  14
gacatcaaga tgacccagtc tccatcttcc atgtatgcat ctctaggaga gagagtcact     60

accgcttgca aggcgagtca ggacattaat acctatttaa gctggttcca gcagaaacca    120

gggaaatctc ctaagaccct gatctatcgt gcaaacagat tggtagatgg ggtcccatca    180

aggttcagtg gccgtggatc tgggcaagat tattctctca ccatcagcag cctggaatat    240

gaagatatgg gaatttatta ttgtctacag tatgatgaat ttccgttcac gttcggagga    300

gggaccacgc tggaaataaa acgg                                           324


<210>  15
<211>  339
<212>  DNA
<213>  mus musculus

<400>  15
gaggtccagc tgcaacagtc tggacctgag ctggtgaagc ctggggcttc agtgaagata     60

tcctgcaaga cttctggata cacattcact gaatacaaca tgtactgggt gaagcagagc    120

catgtaaaga gccttgagtg gattggaggt attaatccta acaattgtga tactacctac    180

aaccagaaat tcaagggcaa ggccacattg actgttgaca agtcctccag cacagcctac    240

atggaactcc gcagcctttc atctgaggat tctgcagtct atttctgtgc agggttggtt    300

gcttactggg gccaagggac tctggtcact gtctctgca                           339


