SEQUENCE LISTING

<110>  Centocor, Inc.

<120>  Anti-Tissue Factor Antibodies and Compositions with Enhanced           	 Effector Function

<130>  CEN5179PCT

<140>  To Be Assigned
<141>  2008-04-28

<140>  60/914882
<141>  2007-04-30

<160>  16    

<170>  PatentIn version 3.3

<210>  1
<211>  1341
<212>  DNA
<213>  Homo sapiens

<400>  1

caagttcagc tggtggagtc tggaggagga gtagtacaac ctggaaggtc actgagactg     60
tcttgtaagg ctagtggatt caatatcaag gactattata tgcactgggt cagacaagct    120
cctggaaaag gactcgagtg gataggttta attgatcctg agaatggtaa cacgatatat    180
gatcccaagt tccaaggaag attcacaatt tctgcagaca actctaagaa tacactgttc    240
ctgcagatgg actcactcag acctgaggat acagcagtct actattgtgc tagagataac    300
agttattact tcgactactg gggccaagga acaccagtca ccgtgagctc agcctccacc    360
aagggcccat cggtcttccc cctggcaccc tcctccaaga gcacctctgg gggcacagcg    420
gccctgggct gcctggtcaa ggactacttc cccgaaccgg tgacggtgtc gtggaactca    480
ggcgccctga ccagcggcgt gcacaccttc ccggctgtcc tacagtcctc aggactctac    540
tccctcagca gcgtggtgac cgtgccctcc agcagcttgg gcacccagac ctacatctgc    600
aacgtgaatc acaagcccag caacaccaag gtggacaaga aagttgagcc caaatcttgt    660
gacaaaactc acacatgccc accgtgccca gcacctgaac tcctgggggg accgtcagtc    720
ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcaca    780
tgcgtggtgg tggacgtgag ccacgaagac cctgaggtca agttcaactg gtacgtggac    840
ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagtacaa cagcacgtac    900
cgggtggtca gcgtcctcac cgtcctgcac caggactggc tgaatggcaa ggagtacaag    960
tgcaaggtct ccaacaaagc cctcccagcc cccatcgaga aaaccatctc caaagccaaa   1020
gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggatga gctgaccaag   1080
aaccaggtca gcctgacctg cctggtcaaa ggcttctatc ccagcgacat cgccgtggag   1140
tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc   1200
gacggctcct tcttcctcta cagcaagctc accgtggaca agagcaggtg gcagcagggg   1260
aacgtcttct catgctccgt gatgcatgag gctctgcaca accactacac gcagaagagc   1320
ctctccctgt ctccgggtaa a                                             1341


<210>  2
<211>  447
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  DOMAIN
<222>  (1)..(117)

<220>
<221>  SITE
<222>  (31)..(35)
<223>  CDR1

<220>
<221>  SITE
<222>  (50)..(66)
<223>  CDR2

<220>
<221>  SITE
<222>  (99)..(106)
<223>  CDR3

<220>
<221>  MUTAGEN
<222>  (239)..(239)
<223>  X= Serine or Aspartate

<220>
<221>  MUTAGEN
<222>  (264)..(264)
<223>  X = Valine or  Isoleucine

<220>
<221>  MUTAGEN
<222>  (330)..(330)
<223>  X = Alanine, Isoleucine or Tyrosine

<220>
<221>  MUTAGEN
<222>  (332)..(332)
<223>  X = Isoleucine or Glutamate

<400>  2

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      
Ser Leu Arg Leu Ser Cys Lys Ala Ser Gly Phe Asn Ile Lys Asp Tyr 
            20                  25                  30          
Tyr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              
Gly Leu Ile Asp Pro Glu Asn Gly Asn Thr Ile Tyr Asp Pro Lys Phe 
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Ala Asp Asn Ser Lys Asn Thr Leu Phe 
65                  70                  75                  80  
Leu Gln Met Asp Ser Leu Arg Pro Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      
Ala Arg Asp Asn Ser Tyr Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Pro 
            100                 105                 110         
Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             
Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 
Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 
Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     
Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         
Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 
        195                 200                 205             
Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His 
    210                 215                 220                 
Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Xaa Val 
225                 230                 235                 240 
Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     
Pro Glu Val Thr Cys Val Val Xaa Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         
Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             
Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 
Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 
Cys Lys Val Ser Asn Lys Ala Leu Pro Xaa Pro Xaa Glu Lys Thr Ile 
                325                 330                 335     
Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         
Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             
Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 
Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 
Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     
Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         
His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  3
<211>  645
<212>  DNA
<213>  Homo sapiens

<400>  3

gatatccaaa tgacacaatc tccttcttct ctaagtgctt ctgtcggaga tagagtaaca     60
attacatgta aggcgagtca ggacattaga aagtatttaa actggtatca gcaaaaacct    120
gggaaggctc ctaagctact gatttattat gcaacaagtt tggcagatgg agtaccttct    180
agattttctg gttctggctc tggaacagac tacacattca caatttcttc tctccaacct    240
gaggacattg ctacatacta ctgcctacaa catggtgaga gtccgtatac atttggacaa    300
ggaacaaaac tagagatcac acgaactgtg gctgcaccat ctgtcttcat cttcccgcca    360
tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat    420
cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag    480
gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg    540
ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    600
ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gttag                    645


<210>  4
<211>  214
<212>  PRT
<213>  Artificial Sequence


<220>
<221>  DOMAIN
<222>  (1)..(108)
<223>  Variable Domain

<220>
<221>  SITE
<222>  (24)..(34)
<223>  CDR1

<220>
<221>  SITE
<222>  (50)..(56)
<223>  CDR2

<220>
<221>  SITE
<222>  (89)..(97)
<223>  CDR3

<400>  4

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      
Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Arg Lys Tyr 
            20                  25                  30          
Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              
Tyr Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  
Ser Gly Ser Gly Thr Asp Tyr Thr Phe Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  
Glu Asp Ile Ala Thr Tyr Tyr Cys Leu Gln His Gly Glu Ser Pro Tyr 
                85                  90                  95      
Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Thr Arg Thr Val Ala Ala 
            100                 105                 110         
Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             
Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 
Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 
Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     
Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         
Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             
Phe Asn Arg Gly Glu Cys 
    210                 


<210>  5
<211>  43
<212>  DNA
<213>  Homo Sapiens

<400>  5

caaagccctc ccagctccgg aggagaaaac catctccaaa gcc                   43


<210>  6
<211>  43
<212>  DNA
<213>  Homo sapiens

<400>  6

ggctttggag atggttttct cctccggagc tgggagggct ttg                   43


<210>  7
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  7

caacaaagcc ctcccaatcc cgatcgagaa aaccatctc                        39


<210>  8
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  8

gagatggttt tctcgatcgg gattgggagg gctttgttg                        39


<210>  9
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  9

caacaaagcc ctcccatacc cgatcgagaa aaccatctc                        39


<210>  10
<211>  39
<212>  DNA
<213>  Homo sapiens

<400>  10

gagctggttt tctcgagcgg gtatgggagg gctttgttg                        39


<210>  11
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  11

ccaacaaagc cctcccaatc ccggaggaga aaaccatc                         38


<210>  12
<211>  38
<212>  DNA
<213>  Homo sapiens

<400>  12

gatggttttc tcctccggga ttgggagggc tttgttgg                         38


<210>  13
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  13

gaggtcacat gcgtggtcat cgatgtgagc cacgaagacc                       40


<210>  14
<211>  40
<212>  DNA
<213>  Homo sapiens

<400>  14

ggtcttcgtg gctcacatcg atgaccacgc atgtgacctc                       40


<210>  15
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  15

ctcctggggg gtccggacgt cttcctcttc ccc                              33


<210>  16
<211>  33
<212>  DNA
<213>  Homo sapiens

<400>  16

ggggaagagg aagacgtccg gaccccccag gag                              33












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