                         SEQUENCE LISTING

<110>  Fox Chase Cancer Center
       Zaret, Kenneth S.
       Kashima, Yasushige
 
<120>  COMPOSITIONS AND METHODS FOR ALTERING PANCREAS OR LIVER FUNCTION

<130>  FCC0008WO

<150>  60/915,727
<151>  2007-05-03

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  628
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Gly Ser Cys Ala Arg Leu Leu Leu Leu Trp Gly Cys Thr Val Val 
1               5                   10                  15      


Ala Ala Gly Leu Ser Gly Val Ala Gly Val Ser Ser Arg Cys Glu Lys 
            20                  25                  30          


Ala Cys Asn Pro Arg Met Gly Asn Leu Ala Leu Gly Arg Lys Leu Trp 
        35                  40                  45              


Ala Asp Thr Thr Cys Gly Gln Asn Ala Thr Glu Leu Tyr Cys Phe Tyr 
    50                  55                  60                  


Ser Glu Asn Thr Asp Leu Thr Cys Arg Gln Pro Lys Cys Asp Lys Cys 
65                  70                  75                  80  


Asn Ala Ala Tyr Pro His Leu Ala His Leu Pro Ser Ala Met Ala Asp 
                85                  90                  95      


Ser Ser Phe Arg Phe Pro Arg Thr Trp Trp Gln Ser Ala Glu Asp Val 
            100                 105                 110         


His Arg Glu Lys Ile Gln Leu Asp Leu Glu Ala Glu Phe Tyr Phe Thr 
        115                 120                 125             


His Leu Ile Val Met Phe Lys Ser Pro Arg Pro Ala Ala Met Val Leu 
    130                 135                 140                 




Asp Arg Ser Gln Asp Phe Gly Lys Thr Trp Lys Pro Tyr Lys Tyr Phe 
145                 150                 155                 160 


Ala Thr Asn Cys Ser Ala Thr Phe Gly Leu Glu Asp Asp Val Val Lys 
                165                 170                 175     


Lys Gly Ala Ile Cys Thr Ser Lys Tyr Ser Ser Pro Phe Pro Cys Thr 
            180                 185                 190         


Gly Gly Glu Val Ile Phe Lys Ala Leu Ser Pro Pro Tyr Asp Thr Glu 
        195                 200                 205             


Asn Pro Tyr Ser Ala Lys Val Gln Glu Gln Leu Lys Ile Thr Asn Leu 
    210                 215                 220                 


Arg Val Gln Leu Leu Lys Arg Gln Ser Cys Pro Cys Gln Arg Asn Asp 
225                 230                 235                 240 


Leu Asn Glu Glu Pro Gln His Phe Thr His Tyr Ala Ile Tyr Asp Phe 
                245                 250                 255     


Ile Val Lys Gly Ser Cys Phe Cys Asn Gly His Ala Asp Gln Cys Ile 
            260                 265                 270         


Pro Val His Gly Phe Arg Pro Val Lys Ala Pro Gly Thr Phe His Met 
        275                 280                 285             


Val His Gly Lys Cys Met Cys Lys His Asn Thr Ala Gly Ser His Cys 
    290                 295                 300                 


Gln His Cys Ala Pro Leu Tyr Asn Asp Arg Pro Trp Glu Ala Ala Asp 
305                 310                 315                 320 


Gly Lys Thr Gly Ala Pro Asn Glu Cys Arg Thr Cys Lys Cys Asn Gly 
                325                 330                 335     


His Ala Asp Thr Cys His Phe Asp Val Asn Val Trp Glu Ala Ser Gly 
            340                 345                 350         


Asn Arg Ser Gly Gly Val Cys Asp Asp Cys Gln His Asn Thr Glu Gly 
        355                 360                 365             


Gln Tyr Cys Gln Arg Cys Lys Pro Gly Phe Tyr Arg Asp Leu Arg Arg 
    370                 375                 380                 


Pro Phe Ser Ala Pro Asp Ala Cys Lys Pro Cys Ser Cys His Pro Val 
385                 390                 395                 400 


Gly Ser Ala Val Leu Pro Ala Asn Ser Val Thr Phe Cys Asp Pro Ser 
                405                 410                 415     


Asn Gly Asp Cys Pro Cys Lys Pro Gly Val Ala Gly Arg Arg Cys Asp 
            420                 425                 430         


Arg Cys Met Val Gly Tyr Trp Gly Phe Gly Asp Tyr Gly Cys Arg Pro 
        435                 440                 445             


Cys Asp Cys Ala Gly Ser Cys Asp Pro Ile Thr Gly Asp Cys Ile Ser 
    450                 455                 460                 


Ser His Thr Asp Ile Asp Trp Tyr His Glu Val Pro Asp Phe Arg Pro 
465                 470                 475                 480 


Val His Asn Lys Ser Glu Pro Ala Trp Glu Trp Glu Asp Ala Gln Gly 
                485                 490                 495     


Phe Ser Ala Leu Leu His Ser Gly Lys Cys Glu Cys Lys Glu Gln Thr 
            500                 505                 510         


Leu Gly Asn Ala Lys Ala Phe Cys Gly Met Lys Tyr Ser Tyr Val Leu 
        515                 520                 525             


Lys Ile Lys Ile Leu Ser Ala His Asp Lys Gly Thr His Val Glu Val 
    530                 535                 540                 


Asn Val Lys Ile Lys Lys Val Leu Lys Ser Thr Lys Leu Lys Ile Phe 
545                 550                 555                 560 


Arg Gly Lys Arg Thr Leu Tyr Pro Glu Ser Trp Thr Asp Arg Gly Cys 
                565                 570                 575     


Thr Cys Pro Ile Leu Asn Pro Gly Leu Glu Tyr Leu Val Ala Gly His 
            580                 585                 590         


Glu Asp Ile Arg Thr Gly Lys Leu Ile Val Asn Met Lys Ser Phe Val 
        595                 600                 605             


Gln His Trp Lys Pro Ser Leu Gly Arg Lys Val Met Asp Ile Leu Lys 
    610                 615                 620                 


Arg Glu Cys Lys 
625             





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