                         SEQUENCE LISTING

<110>  Hotamisligil, Gokhan S.
       Wellen, Kathryn  E.
       Saatcioglu, Farhi
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC DISORDERS
        AND INFLAMMATION

<130>  67937PCT(70207)

<160>  42    

<170>  PatentIn version 3.3

<210>  1
<211>  2030
<212>  DNA
<213>  Homo sapiens

<400>  1
acattctctt cagccaaagt caagtggtct tcaggatcat tcacacagtt gtacaggact     60

acagttcaca aacgacaaga ggaatgaatc aagtatctgg ttactacctg gccattcact    120

actattattt actattgtaa gctatgtcat cacaaacaca acagatcctc ttaaccagaa    180

tcaataactc ttggaatctt atcgtttact gcaccacaat tgagcagcct gctgcatata    240

acatgaactg cccagaagaa aacaatgcag aggtcagaat gtctgctgcc cttggcaact    300

gtcttttcac agtacctggt attccactgg caactaatac atctgcattc tacatgtaaa    360

tcgcacagtc agtatgtcaa aattgggtct ctgtatcaac aaggcttaaa gccccatggc    420

aaatcatcag cacaaggcac ataaggacct ccataagcct gcgctctaaa gtcccgatct    480

tcccagtctc tcacccagct gtcaagttca ccaatcatga gggttcgttc ttcttggaga    540

cacagctgga tgtcttcttc cctagactca tacctttctc accggtgagt cttcaaacct    600

agaaaattca atcacaaaat tagcgggtgt tttttgtttt gttatgttta agttcttttc    660

tggcctacag atagtattga tgaactctgc aaaatacaag aatggggagt aggtttatca    720

ataagcacag tagctattcg agatgtggta ctatatcagg tatgatgaaa acccgcccac    780

aaagagctac aaacgtagta agtctcttaa ggagtgagat gccctaacca tgtcactcaa    840

agaagttatt taatcaacta gctgtcagga caagacctct ggggagacgc tgaggtccca    900

gctgactcca caggtcatag gaagagagtt gcaatcaagg caaagaagag tctggttcat    960

aagttctgag aacacactcc cctgagactg tgaatctgaa ctttggcaag agtgccatgg   1020

aagttaaacc agatggttgg gagaaagaca aacttgaaga atgctgtatt ttaacagcaa   1080

cgtaggcatg ctctttcctc cacgttgtca tgtttcttta tgtctgaaag caccgtaggg   1140

gtagatttgg gttcctctat agaaagatac accaacccaa ttgtatacgt ggtcagccct   1200

tcacttccat gggttttcca agcatggttt caataaacaa tgaatcaaaa ctatttagaa   1260

aaaaaatata ttcatctttt ctgcatgtgt aagcaggtat tgttgtttgg ttgttgtctt   1320

tctctcccaa acaataaagt gtggcatcca tttaggtaac atttgtattg cattgttacc   1380

atgtagggaa ggaattaaca ggaggagatg cacacagctg cctgggtata agcaaacttg   1440

gagccctgga gaacacagag atacatatgc atttgagatg aagacctgaa aactctccat   1500

cttttaagct ctgactctgt taaaaatcag ggctcctggc aggagaaaga caccactatt   1560

tcgtaagaag agaggcaact aagaggaatg cctaagctcc ttgcccatgt actgttttct   1620

tagctaccca gagtcctcta gctctaacag aaaaggagta tctctctgcc cctctaggct   1680

gcagctgacc tgggatgccc caccccaaag gttccggaaa acccctttta taccccgctt   1740

ggcagcggag aacgtccatc tgcgagccag agctgcacaa taagttctgg tccttccagc   1800

tgtgcgggat tcccaggttg aactcttccc ggaaactttg cttcacagct cctcttgcga   1860

aatcaagcgg gccctccctc cgctctttgg cttaaaagcg ggagcctgga gccagcgcag   1920

agcacaggct ggctacctct gcaagcctag aaggcagagc ccaccgcagc cgcgccagac   1980

caacgcccct ccgggcgcct cgccgcaggt gggtcacttt actggctctt              2030


<210>  2
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  2
gatggcagag atggcactcc                                                 20


<210>  3
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  3
cttgccagtg ctgccgtcat                                                 20


<210>  4
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  4
agcgaccaga tgaagcagtg                                                 20


<210>  5
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  5
tccgctctct gtcaaagtgt g                                               21


<210>  6
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  6
ggaggtggtg atagccggta t                                               21


<210>  7
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  7
tgggtaatcc atagagccca g                                               21


<210>  8
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  8
aagaatggag cctatccggt g                                               21


<210>  9
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  9
ccatcacttc gtaaccttgc c                                               21


<210>  10
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  10
acaaccacgg ccttccctac tt                                              22


<210>  11
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  11
cacgatttcc cagagaacat gtg                                             23


<210>  12
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  12
ccactcacct gctgctactc at                                              22


<210>  13
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  13
tggtgatcct cttgtagctc tcc                                             23


<210>  14
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  14
ggttggggct gaacattttt c                                               21


<210>  15
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  15
tcgacacaca ggaatcagga t                                               21


<210>  16
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  16
ttcttgcgat acactctggt gc                                              22


<210>  17
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  17
cgggattgaa tgttcttgtc gt                                              22


<210>  18
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  18
cacagcaagt ttcccgccgc c                                               21


<210>  19
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  19
gtgcaccagc ttgagtacac a                                               21


<210>  20
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  20
aaccagttgt gttgtcagga c                                               21


<210>  21
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  21
ccaccatgtt tcttagagtg agg                                             23


<210>  22
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  22
tcaaatgcgg aataccttgc t                                               21


<210>  23
<211>  22
<212>  DNA
<213>  Mus musculus

<400>  23
gcatctagtg ttcctgactg ga                                              22


<210>  24
<211>  20
<212>  DNA
<213>  Mus musculus

<400>  24
ggtcgccatt accctcttgg                                                 20


<210>  25
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  25
ggtatgagag actgtaaaca gcg                                             23


<210>  26
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  26
cccgtccatt gctaattccc t                                               21


<210>  27
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  27
cagaaaagag acccgaaccc a                                               21


<210>  28
<211>  23
<212>  DNA
<213>  Mus musculus

<400>  28
ccctcacact cagatcatct tct                                             23


<210>  29
<211>  19
<212>  DNA
<213>  Mus musculus

<400>  29
gctacgacgt gggctacag                                                  19


<210>  30
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  30
aagcagcatc caagtctgac a                                               21


<210>  31
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  31
ugcagaguac cuugcucaut t                                               21


<210>  32
<211>  21
<212>  DNA
<213>  Homo sapiens


<220>
<221>  RNA
<222>  (1)..(19)

<220>
<221>  DNA
<222>  (20)..(21)

<400>  32
augagcaagg uacucugcat t                                               21


<210>  33
<211>  97
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  33
tgctgttgac agtgagcgcg cacttcctct tactatgaat tagtgaagcc acagatgtaa     60

ttcatagtaa gaggaagtgc atgcctactg cctcgga                              97


<210>  34
<211>  97
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic

<400>  34
tgctgttgac agtgagcgcg ccaagaagtc tgacatcata tagtgaagcc acagatgtat     60

atgatgtcag acttcttggc ttgcctactg cctcgga                              97


<210>  35
<211>  3140
<212>  DNA
<213>  Mus musculus

<400>  35
ctgcaagcct agaaggcaga gcccaccgca gccgcgccag accaacgccc ctccgggcgc     60

ctcgccgcag taatggagaa agcacatgca gatgagtttc ctctgactac tgattcctca    120

gaaaagcaag gggttgtctg cattttcgga acaggagatt tcgggaagtc actgggattg    180

aaaatgcttc agtgtggcta ttctatcgtt tttgggagtc gaaaccccca ggtgtccagc    240

cttctgccca ggggggcaga ggtcctgagc tattcggaag cagcatccaa gtctgacatc    300

ataatcctag ccatgcacag agagcactat gattccctca cggaactagt tgattatctc    360

aaaggaaaag tattggtaga cgtcagtaac aaccgcaaaa tcaatcagta tccagagtca    420

aatgcggaat accttgctca gctggagcca ggagcccacg tggtcaaagc atttaacacc    480

atctcagcct gggctctcca gtcaggaaca ctagatgcaa gccggcaggt gtttgtctgt    540

ggaaatgaca gcaaggccaa acaaagagta atggacattg ctcgtactct tgggctcacc    600

ccactggacc aaggatctct catggcagcc agtgaaattg aaaactaccc tctgcaacta    660

tttccaatgt ggaggtttcc tttctatttg tcctctgtgc tgtgcgtctt cttctttgtg    720

tactgtgcaa tacgagaggt gatatacccc tacgtgaatg ggaaaacaga tgctacgtac    780

cgcctggcca tttccatccc gaatcgtgtc tttcctataa cagcactgat cctgcttgcc    840

ttggtgtacc tccctggtat tctcgctgcc attctgcagc tctatcgagg cacaaagtac    900

cgccgattcc caaactggct tgaccattgg atgctttgca gaaagcaact gggcttggta    960

gctctgggat ttgccttcct tcatgtcatc tacacacttg tgattcctat ccgttactat   1020

gttcgatgga ggctgagaaa tgcaaccatt actcaggccc taactaataa agacagccca   1080

tttattacct cttatgcctg gattaatgat tcctacttgg cgctgggaat cctgggattt   1140

tttctgttcc ttctgttggg aatcacttcc ttgccatcag taagcaacat ggtcaactgg   1200

agagagttcc ggtttgttca gtccaaactg ggttatctga ccctggtctt gtgcacagcc   1260

cacactttgg tgtatggcgg aaagagattc ctcagccctt cgattctaag gtggagcctc   1320

ccttcggctt atattttggc actcgtcatc ccctgcgcag tgctggtgct gaagtgcatc   1380

ctcatcatgc catgcataga caagaccctc actcgcatcc gccagggctg ggaaagaaac   1440

tcaaagtaca cacaatcagc actgaacgga aaatcggata tttaagctac agttgaattt   1500

gccaggattt gtgtactatt gcagtaaatg tttagagcat aatgtgtcca gttataagaa   1560

agcattttct cttgtcatgg ccctaacttt atcatcacag taggaagtgt tgcctcactt   1620

tgaaagacca gaatagcaag ggaaccctcg ctgcctcagt cacgtgatga ctcattgtgg   1680

gcctccctca cttcctttcc cagaaacccc agggatgcca ctgtgattag atttacagtt   1740

ccacacagcg aagcttcttg attatgggca agttgaatga cgcaatgttt tgtagagttc   1800

tggaagagtg tgtgcaactt ccttccctaa ttcaagggct gatgtaagtg aaaaagcagc   1860

actcggcata ctacaggttt tgcttggcat gcctggagaa aagccccaaa tgaaatagac   1920

agaaagaggg ttagtttgtt tcctggaaga agtggtgatc ataactattg tcatactgat   1980

ctgggggtat ttggggttta gctgtagtgc tgagctcaaa cctaaggcct tatgcatgtt   2040

aggtaaatga tatgttactg agccacacac acgccagccg tgccatagtg agtatgtagt   2100

catatgtacc cccttgattt cttgctttta ccaatatgga ttcttactat ggggaaatat   2160

tttatactgc aacaaaattg gtttgaagta gctgttcctt ggatatatgg aaagctatgt   2220

aattgtccca agattcttcc tccacaaagg acggcttgag gggagatggg gtaagagttg   2280

agcagcgatc ctaagttgag ggaagatggg gaaagagtgg aagatccatt gggtttttca   2340

agtgccgcag gcagacacag gctgataata gccttgtaca aaaatgtcag ataagccaga   2400

attttagcta gtaagctacg caaatactaa tacagtttca ctatgctgtt tgggatcatt   2460

taggagtggt ggtgtgcttt cttcattata catttcaaat actgttcagt attaagcatc   2520

tgtgaaatta acttctagta caaacatgta gcttccataa tctgtctttg ttatcaatgt   2580

aagtggtgca gttagaagga atcatctgaa ctcgtcggag cgaggaaagg atagctgaga   2640

gaactgtgga gtgctagggt gtaggcgagc agcagtggac catgggtcgg atgcagccag   2700

ctctggcttc ctgtgtggac agtgcctttc ccaaggtgac cttcagcagg ctgagaatcc   2760

ttagctctag cctggagcta aaaggagatc tttgcacaat cttcccgcgt gtcactgaaa   2820

taaagaaaag gcattgagtt tgacattttt ctgattaatc tacaaagact gtttattttt   2880

catttttcta gcttttatat cgtatattgt acatgatatc atacattgct cacaatccag   2940

ggttttttat ataaagctct tatataacac agacatttct tttactattg ccctaataaa   3000

acatatagag tatattcagt ttttactaag aggacaattg aggtaatgtc tttgtactaa   3060

caaaatattt ctgtattttc aattatttcc ttggaatatt ttccaagagt tagtataaaa   3120

ttaaagaata tttgataaca                                               3140


<210>  36
<211>  470
<212>  PRT
<213>  Mus musculus

<400>  36

Met Glu Lys Ala His Ala Asp Glu Phe Pro Leu Thr Thr Asp Ser Ser 
1               5                   10                  15      


Glu Lys Gln Gly Val Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Lys 
            20                  25                  30          


Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Ile Val Phe Gly 
        35                  40                  45              


Ser Arg Asn Pro Gln Val Ser Ser Leu Leu Pro Arg Gly Ala Glu Val 
    50                  55                  60                  


Leu Ser Tyr Ser Glu Ala Ala Ser Lys Ser Asp Ile Ile Ile Leu Ala 
65                  70                  75                  80  


Met His Arg Glu His Tyr Asp Ser Leu Thr Glu Leu Val Asp Tyr Leu 
                85                  90                  95      


Lys Gly Lys Val Leu Val Asp Val Ser Asn Asn Arg Lys Ile Asn Gln 
            100                 105                 110         


Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala Gln Leu Glu Pro Gly Ala 
        115                 120                 125             


His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser 
    130                 135                 140                 


Gly Thr Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser 
145                 150                 155                 160 


Lys Ala Lys Gln Arg Val Met Asp Ile Ala Arg Thr Leu Gly Leu Thr 
                165                 170                 175     


Pro Leu Asp Gln Gly Ser Leu Met Ala Ala Ser Glu Ile Glu Asn Tyr 
            180                 185                 190         


Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ser 
        195                 200                 205             


Val Leu Cys Val Phe Phe Phe Val Tyr Cys Ala Ile Arg Glu Val Ile 
    210                 215                 220                 


Tyr Pro Tyr Val Asn Gly Lys Thr Asp Ala Thr Tyr Arg Leu Ala Ile 
225                 230                 235                 240 


Ser Ile Pro Asn Arg Val Phe Pro Ile Thr Ala Leu Ile Leu Leu Ala 
                245                 250                 255     


Leu Val Tyr Leu Pro Gly Ile Leu Ala Ala Ile Leu Gln Leu Tyr Arg 
            260                 265                 270         


Gly Thr Lys Tyr Arg Arg Phe Pro Asn Trp Leu Asp His Trp Met Leu 
        275                 280                 285             


Cys Arg Lys Gln Leu Gly Leu Val Ala Leu Gly Phe Ala Phe Leu His 
    290                 295                 300                 


Val Ile Tyr Thr Leu Val Ile Pro Ile Arg Tyr Tyr Val Arg Trp Arg 
305                 310                 315                 320 


Leu Arg Asn Ala Thr Ile Thr Gln Ala Leu Thr Asn Lys Asp Ser Pro 
                325                 330                 335     


Phe Ile Thr Ser Tyr Ala Trp Ile Asn Asp Ser Tyr Leu Ala Leu Gly 
            340                 345                 350         


Ile Leu Gly Phe Phe Leu Phe Leu Leu Leu Gly Ile Thr Ser Leu Pro 
        355                 360                 365             


Ser Val Ser Asn Met Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser 
    370                 375                 380                 


Lys Leu Gly Tyr Leu Thr Leu Val Leu Cys Thr Ala His Thr Leu Val 
385                 390                 395                 400 


Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Ile Leu Arg Trp Ser Leu 
                405                 410                 415     


Pro Ser Ala Tyr Ile Leu Ala Leu Val Ile Pro Cys Ala Val Leu Val 
            420                 425                 430         


Leu Lys Cys Ile Leu Ile Met Pro Cys Ile Asp Lys Thr Leu Thr Arg 
        435                 440                 445             


Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys Tyr Thr Gln Ser Ala Leu 
    450                 455                 460                 


Asn Gly Lys Ser Asp Ile 
465                 470 


<210>  37
<211>  4454
<212>  DNA
<213>  Homo sapiens

<400>  37
agcgctgagc tgcaggcgcg gcgaaacttc cctctacccg cccggcccgc ggcgcgcacc     60

gttggcgctg gacgcttcct ccttggaagc gcctctccct cagttatgga gaaaacttgt    120

atagatgcac ttcctcttac tatgaattct tcagaaaagc aagagactgt atgtattttt    180

ggaactggtg attttggaag atcactggga ttgaaaatgc tccagtgtgg ttattctgtt    240

gtttttggaa gtcgaaaccc ccagaagacc accctactgc ccagtggtgc agaagtcttg    300

agctattcag aagcagccaa gaagtctggc atcataatca tagcaatcca cagagagcat    360

tatgattttc tcacagaatt aactgaggtt ctcaatggaa aaatattggt agacatcagc    420

aacaacctca aaatcaatca atatccagaa tctaatgcag agtaccttgc tcatttggtg    480

ccaggagccc acgtggtaaa agcatttaac accatctcag cctgggctct ccagtcagga    540

gcactggatg caagtcggca ggtgtttgtg tgtggaaatg acagcaaagc caagcaaaga    600

gtgatggata ttgttcgtaa tcttggactt actccaatgg atcaaggatc actcatggca    660

gccaaagaaa ttgaaaagta ccccctgcag ctatttccaa tgtggaggtt ccccttctat    720

ttgtctgctg tgctgtgtgt cttcttgttt ttctattgtg ttataagaga cgtaatctac    780

ccttatgttt atgaaaagaa agataataca tttcgtatgg ctatttccat tccaaatcgt    840

atctttccaa taacagcact tacactgctt gctttggttt acctccctgg tgttattgct    900

gccattctac aactgtaccg aggcacaaaa taccgtcgat tcccagactg gcttgaccac    960

tggatgcttt gccgaaagca gcttggcttg gtagctctgg gatttgcctt ccttcatgtc   1020

ctctacacac ttgtgattcc tattcgatat tatgtacgat ggagattggg aaacttaacc   1080

gttacccagg caatactcaa gaaggagaat ccatttagca cctcctcagc ctggctcagt   1140

gattcatatg tggctttggg aatacttggg ttttttctgt ttgtactctt gggaatcact   1200

tctttgccat ctgttagcaa tgcagtcaac tggagagagt tccgatttgt ccagtccaaa   1260

ctgggttatt tgaccctgat cttgtgtaca gcccacaccc tggtgtacgg tgggaagaga   1320

ttcctcagcc cttcaaatct cagatggtat cttcctgcag cctacgtgtt agggcttatc   1380

attccttgca ctgtgctggt gatcaagttt gtcctaatca tgccatgtgt agacaacacc   1440

cttacaagga tccgccaggg ctgggaaagg aactcaaaac actagaaaaa gcattgaatg   1500

gaaaatcaat atttaaaaca aagttcaatt tagctggatt tctgaactat ggttttgaat   1560

gtttaaagaa gaatgatggg tacagttagg aaagtttttt tcttacaccg tgactgaggg   1620

aaacattgct tgtctttgag aaattgactg acatactgga agagaacacc attttatctc   1680

aggttagtga agaatcagtg caggtccctg actcttattt tcccagaggc catggagctg   1740

agattgagac tagccttgtg gtttcacact aaagagtttc cttgttatgg gcaacatgca   1800

tgacctaatg tcttgcaaaa tccaatagaa gtattgcagc ttccttctct ggctcaaggg   1860

ctgagttaag tgaaaggaaa aacagcacaa tggtgaccac tgataaaggc tttattaggt   1920

atatctgagg aagtgggtca catgaaatgt aaaaagggaa tgaggttttt gttgtttttt   1980

ggaagtaaag gcaaacataa atattaccat gatgaattct agtgaaatga ccccttgact   2040

ttgcttttct taatacagat atttactgag aggaactatt tttataacac aagaaaaatt   2100

tacaattgat taaaagtatc catgtcttgg atacatacgt atctatagag ctggcatgta   2160

attcttcctc tataaagaat aggtatagga aagactgaat aaaaatggag ggatatcccc   2220

ttggatttca cttgcattgt gcaataagca aagaagggtt gataaaagtt cttgatcaaa   2280

aagttcaaag aaaccagaat tttagacagc aagctaaata aatattgtaa aattgcacta   2340

tattaggtta agtattattt aggtattata atatgctttg taaattttat attccaaata   2400

ttgctcaata tttttcatct attaaattaa tttctagtgt aaataagtag cttctatatc   2460

tgtcttagtc tattataatt gtaaggagta aaattaaatg aatagtctgc aggtataaat   2520

ttgaacaatg catagatgat cgaaaattac ggaaaatcat agggcagaga ggtgtgaaga   2580

ttcatcatta tgtgaaattt ggatctttct caaatccttg ctgaaattta ggatggttct   2640

cactgttttt ctgtgctgat agtacccttt ccaaggtgac cttcaggggg attaaccttc   2700

ctagctcaag caatgagcta aaaggagcct tatgcatgat cttcccacat atcaaaataa   2760

ctaaaaggca ctgagtttgg catttttctg cctgctctgc taagaccttt tttttttttt   2820

actttcatta taacatatta tacatgacat tatacaaaaa tgattaaaat atattaaaac   2880

aacatcaaca atccaggata tttttctata aaacttttta aaaataattg tatctatata   2940

ttcaatttta catccttttt caaaggcttt gtttttctaa aggctttgtt ttccttttta   3000

ttattttttt cttttttatt tttttgagac agtcttgctc tgtcgctcag gctggagtgc   3060

agtggcacga tctcagctca ctgcaacctc ctcctcccag gttcaagtga ttcttgttca   3120

tcagcctccc gagtagctgg gactacaggc atgtgccact atgcccagct aatttttgta   3180

cttttagtag agacagggtt tcaccacatt ggtcaggctg gtcttgaaat gctggcgtca   3240

agtgatctgc ctgcctccgc ctcacaaagc actgggatta caggcatgaa tctggcctta   3300

cgtaatatat tttcttaatg gctgcataat atcacatcaa ataggcattt ttcaaacctc   3360

tttccttatt aaacatgtag actatatcca ttttttacta aaataaataa catttcagat   3420

aatatctttg cactgataat gttgccaagc catttctaaa gtgaccttat caatttaatt   3480

accattggat gagggtgttg ctttcatcgc accattgtag attgtctttt ttatttcaat   3540

ttgcgtttat ttataactgg ttgcaaaggt acacagaaca cacgctcctt caacttatct   3600

ttgataaacc caagcaagga tacaaaaagt tggacgacat tgagtagagt catggtatac   3660

ggtgctgacc ctacagtatc agtggaaaag ataaggaaaa tgtcactact cacctatgtt   3720

atgcaaaaca gttaggtgtg ctggggctgg atactgctct tttacttgag cattggttga   3780

ttaaagttta ggtaccatcc aggctggtct agagaagtct ttggagttaa ccatgctctt   3840

tttgttaaag aagagagtaa tgtgtttatc ctggctcata gtccgtcacc gaaaatagaa   3900

aatgccatcc ataggtaaaa tgctgaccta tagaaaaaaa tgaactctac ttttatagcc   3960

tagtaaaaat gctctacctg agtagttaaa agcaattcat gaagcctgaa gctaaagagc   4020

actctgatgg ttttggcata atagctgcat ttccagacct gacctttggc cccaaccaca   4080

agtgctccaa gccccaccag ctgaccaaag aaagcccaag ttctccttct gtccttccca   4140

caacctccct gctcccaaaa ctatgaaatt aatttgacca tattaacaca gctgactcct   4200

ccagtttact taaggtagaa agaatgagtt tacaacagat gaaaataagt gctttgggcg   4260

aactgtattc cttttaacag atccaaacta ttttacattt aaaaaaaaag ttaaactaaa   4320

cttctttact gctgatatgt ttcctgtatt ctagaaaaat ttttacactt tcacattatt   4380

tttgtacact ttccccatgt taagggatga tggcttttat aaatgtgtat tcattaaatg   4440

ttactttaaa aata                                                     4454


<210>  38
<211>  459
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Lys Thr Cys Ile Asp Ala Leu Pro Leu Thr Met Asn Ser Ser 
1               5                   10                  15      


Glu Lys Gln Glu Thr Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Arg 
            20                  25                  30          


Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Val Val Phe Gly 
        35                  40                  45              


Ser Arg Asn Pro Gln Lys Thr Thr Leu Leu Pro Ser Gly Ala Glu Val 
    50                  55                  60                  


Leu Ser Tyr Ser Glu Ala Ala Lys Lys Ser Gly Ile Ile Ile Ile Ala 
65                  70                  75                  80  


Ile His Arg Glu His Tyr Asp Phe Leu Thr Glu Leu Thr Glu Val Leu 
                85                  90                  95      


Asn Gly Lys Ile Leu Val Asp Ile Ser Asn Asn Leu Lys Ile Asn Gln 
            100                 105                 110         


Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala His Leu Val Pro Gly Ala 
        115                 120                 125             


His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser 
    130                 135                 140                 


Gly Ala Leu Asp Ala Ser Arg Gln Val Phe Val Cys Gly Asn Asp Ser 
145                 150                 155                 160 


Lys Ala Lys Gln Arg Val Met Asp Ile Val Arg Asn Leu Gly Leu Thr 
                165                 170                 175     


Pro Met Asp Gln Gly Ser Leu Met Ala Ala Lys Glu Ile Glu Lys Tyr 
            180                 185                 190         


Pro Leu Gln Leu Phe Pro Met Trp Arg Phe Pro Phe Tyr Leu Ser Ala 
        195                 200                 205             


Val Leu Cys Val Phe Leu Phe Phe Tyr Cys Val Ile Arg Asp Val Ile 
    210                 215                 220                 


Tyr Pro Tyr Val Tyr Glu Lys Lys Asp Asn Thr Phe Arg Met Ala Ile 
225                 230                 235                 240 


Ser Ile Pro Asn Arg Ile Phe Pro Ile Thr Ala Leu Thr Leu Leu Ala 
                245                 250                 255     


Leu Val Tyr Leu Pro Gly Val Ile Ala Ala Ile Leu Gln Leu Tyr Arg 
            260                 265                 270         


Gly Thr Lys Tyr Arg Arg Phe Pro Asp Trp Leu Asp His Trp Met Leu 
        275                 280                 285             


Cys Arg Lys Gln Leu Gly Leu Val Ala Leu Gly Phe Ala Phe Leu His 
    290                 295                 300                 


Val Leu Tyr Thr Leu Val Ile Pro Ile Arg Tyr Tyr Val Arg Trp Arg 
305                 310                 315                 320 


Leu Gly Asn Leu Thr Val Thr Gln Ala Ile Leu Lys Lys Glu Asn Pro 
                325                 330                 335     


Phe Ser Thr Ser Ser Ala Trp Leu Ser Asp Ser Tyr Val Ala Leu Gly 
            340                 345                 350         


Ile Leu Gly Phe Phe Leu Phe Val Leu Leu Gly Ile Thr Ser Leu Pro 
        355                 360                 365             


Ser Val Ser Asn Ala Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser 
    370                 375                 380                 


Lys Leu Gly Tyr Leu Thr Leu Ile Leu Cys Thr Ala His Thr Leu Val 
385                 390                 395                 400 


Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Asn Leu Arg Trp Tyr Leu 
                405                 410                 415     


Pro Ala Ala Tyr Val Leu Gly Leu Ile Ile Pro Cys Thr Val Leu Val 
            420                 425                 430         


Ile Lys Phe Val Leu Ile Met Pro Cys Val Asp Asn Thr Leu Thr Arg 
        435                 440                 445             


Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys His 
    450                 455                 


<210>  39
<211>  2350
<212>  DNA
<213>  Homo sapiens

<400>  39
gagctgcagg cgcggcgaaa cttccctcta cccgcccggc ccgcggcgcg caccgttggc     60

gctggacgct tcctccttgg aagcgcctct ccctcagtta tggagaaaac ttgtatagat    120

gcacttcctc ttactatgaa ttcttcagaa aagcaagaga ctgtatgtat ttttggaact    180

ggtgattttg gaagatcact gggattgaaa atgctccagt gtggttattc tgttgttttt    240

ggaagtcgaa acccccagaa gaccacccta ctgcccagtg gtgcagaagt cttgagctat    300

tcagaagcag ccaagaagtc tggcatcata atcatagcaa tccacagaga gcattatgat    360

tttctcacag aattaactga ggttctcaat ggaaaaatat tggtagacat cagcaacaac    420

ctcaaaatca atcaatatcc agaatctaat gcagagtacc ttgctcattt ggtgccagga    480

gcccacgtgg taaaagcatt taacaccatc tcagcctggg ctctccagtc aggagcactg    540

gatgcaagtc ggcaggcaat actcaagaag gagaatccat ttagcacctc ctcagcctgg    600

ctcagtgatt catatgtggc tttgggaata cttgggtttt ttctgtttgt actcttggga    660

atcacttctt tgccatctgt tagcaatgca gtcaactgga gagagttccg atttgtccag    720

tccaaactgg gttatttgac cctgatcttg tgtacagccc acaccctggt gtacggtggg    780

aagagattcc tcagcccttc aaatctcaga tggtatcttc ctgcagccta cgtgttaggg    840

cttatcattc cttgcactgt gctggtgatc aagtttgtcc taatcatgcc atgtgtagac    900

aacaccctta caaggatccg ccagggctgg gaaaggaact caaaacacta gaaaaagcat    960

tgaatggaaa atcaatattt aaaacaaagt tcaatttagc tggatttctg aactatggtt   1020

ttgaatgttt aaagaagaat gatgggtaca gttaggaaag tttttttctt acaccgtgac   1080

tgagggaaac attgcttgtc tttgagaaat tgactgacat actggaagag aacaccattt   1140

tatctcaggt tagtgaagaa tcagtgcagg tccctgactc ttattttccc agaggccatg   1200

gagctgagat tgagactagc cttgtggttt cacactaaag agtttccttg ttatgggcaa   1260

catgcatgac ctaatgtctt gcaaaatcca atagaagtat tgcagcttcc ttctctggct   1320

caagggctga gttaagtgaa aggaaaaaca gcacaatggt gaccactgat aaaggcttta   1380

ttaggtatat ctgaggaagt gggtcacatg aaatgtaaaa agggaatgag gtttttgttg   1440

ttttttggaa gtaaaggcaa acataaatat taccatgatg aattctagtg aaatgacccc   1500

ttgactttgc ttttcttaat acagatattt actgagagga actattttta taacacaaga   1560

aaaatttaca attgattaaa agtatccatg tcttggatac atacgtatct atagagctgg   1620

catgtaattc ttcctctata aagaataggt ataggaaaga ctgaataaaa atggagggat   1680

atccccttgg atttcacttg cattgtgcaa taagcaaaga agggttgata aaagttcttg   1740

atcaaaaagt tcaaagaaac cagaatttta gacagcaagc taaataaata ttgtaaaatt   1800

gcactatatt aggttaagta ttatttaggt attataatat gctttgtaaa ttttatattc   1860

caaatattgc tcaatatttt tcatctatta aattaatttc tagtgtaaat aagtagcttc   1920

tatatctgtc ttagtctatt ataattgtaa ggagtaaaat taaatgaata gtctgcaggt   1980

ataaatttga acaatgcatg gatgatcgaa aattacggaa aatcataggg cagagaggtg   2040

tgaagattca tcattatgtg aaatttggat ctttctcaaa tccttgctga aatttaggat   2100

ggttctcact gtttttctgt gctgatagta ccctttccaa ggtgaccttc agggggatta   2160

accttcctag ctcaagcaat gagctaaaag gagccttatg catgatcttc ccacatatca   2220

aaataactaa aaggcactga gtttggcatt tttctgcctg ctctgctaag accttttttt   2280

ttttttactt tcattataac atattataca tgacattata caaaaaaaaa aaaaaaaaaa   2340

aaaaaaaaaa                                                          2350


<210>  40
<211>  283
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Glu Lys Thr Cys Ile Asp Ala Leu Pro Leu Thr Met Asn Ser Ser 
1               5                   10                  15      


Glu Lys Gln Glu Thr Val Cys Ile Phe Gly Thr Gly Asp Phe Gly Arg 
            20                  25                  30          


Ser Leu Gly Leu Lys Met Leu Gln Cys Gly Tyr Ser Val Val Phe Gly 
        35                  40                  45              


Ser Arg Asn Pro Gln Lys Thr Thr Leu Leu Pro Ser Gly Ala Glu Val 
    50                  55                  60                  


Leu Ser Tyr Ser Glu Ala Ala Lys Lys Ser Gly Ile Ile Ile Ile Ala 
65                  70                  75                  80  


Ile His Arg Glu His Tyr Asp Phe Leu Thr Glu Leu Thr Glu Val Leu 
                85                  90                  95      


Asn Gly Lys Ile Leu Val Asp Ile Ser Asn Asn Leu Lys Ile Asn Gln 
            100                 105                 110         


Tyr Pro Glu Ser Asn Ala Glu Tyr Leu Ala His Leu Val Pro Gly Ala 
        115                 120                 125             


His Val Val Lys Ala Phe Asn Thr Ile Ser Ala Trp Ala Leu Gln Ser 
    130                 135                 140                 


Gly Ala Leu Asp Ala Ser Arg Gln Ala Ile Leu Lys Lys Glu Asn Pro 
145                 150                 155                 160 


Phe Ser Thr Ser Ser Ala Trp Leu Ser Asp Ser Tyr Val Ala Leu Gly 
                165                 170                 175     


Ile Leu Gly Phe Phe Leu Phe Val Leu Leu Gly Ile Thr Ser Leu Pro 
            180                 185                 190         


Ser Val Ser Asn Ala Val Asn Trp Arg Glu Phe Arg Phe Val Gln Ser 
        195                 200                 205             


Lys Leu Gly Tyr Leu Thr Leu Ile Leu Cys Thr Ala His Thr Leu Val 
    210                 215                 220                 


Tyr Gly Gly Lys Arg Phe Leu Ser Pro Ser Asn Leu Arg Trp Tyr Leu 
225                 230                 235                 240 


Pro Ala Ala Tyr Val Leu Gly Leu Ile Ile Pro Cys Thr Val Leu Val 
                245                 250                 255     


Ile Lys Phe Val Leu Ile Met Pro Cys Val Asp Asn Thr Leu Thr Arg 
            260                 265                 270         


Ile Arg Gln Gly Trp Glu Arg Asn Ser Lys His 
        275                 280             


<210>  41
<211>  1067
<212>  DNA
<213>  Oncorhynchus mykiss

<400>  41
ctgccccaca cacacacaca cacaaacaag caaaacccct ccaacggaat ttccaccttg     60

gcagagagac tactcccttt cctcctccct ccaggagcac gcccagacac aaatagagac    120

tcagtcagtc gtgtctagag gtgtctgctg aagaacttag cgaagtgaaa gggacgttca    180

tcctgcgagc tccatttatg catgacgggt caggagagga gtgaggagaa gagtgagtgt    240

gtgtccctgt ctccgatgat ggaggctgtc cctgccccac ctgagagtga gagggtgtgt    300

gtgtttggga cgggggacct ggggcgctct ctgggcctgc gtctgctgca ggcggggtac    360

ggtgtggtgt tcggcagccg acgcccccac agccgcagca gcctcctacc ccacggagca    420

caggtcctgg gtcatgctgc agctgctcag tcagcccatc tgatcttcat cgctgtccag    480

agagaacact acgacttcct ggtaccactg gccaatcagc tgaagggaaa ggtgttggtg    540

gacctcagta acaacctgag gaagaatcag tacccagagg ccaacgcaga gtacctgcaa    600

agtctggttc ctggagctga ggtggttaaa ggcttcaaca ccttgtctgc ctggagtctg    660

cagaatggac cttcagatgc caacagacag gtgtatatct gcggggaaag tgtggaggcc    720

aagcaggcgg tgatagcggt agccatcaag ctgggtttca gtgccctgga ccggggattt    780

ctctcagtgg cccgggagct ggaggacttc cccctacagc tgttccccca gtggaggctc    840

cccctgcgca tcgccattgg cctcagtgct gccttcttct tctacctgct gatcagagac    900

atcatctatg catacgtcac ccagagcaaa gacatctcct tcagaatcat ggtctcactg    960

gccaacaagg tgtgtcctat cgtgtctctg atcatgctgt ctctctgtta cctgcctggt   1020

gtcctggctt ccttcctgca gctctacaga ggcaccaagt acctgcc                 1067


<210>  42
<211>  289
<212>  PRT
<213>  Oncorhynchus mykiss

<400>  42

Met Thr Gly Gln Glu Arg Ser Glu Glu Lys Ser Glu Cys Val Ser Leu 
1               5                   10                  15      


Ser Pro Met Met Glu Ala Val Pro Ala Pro Pro Glu Ser Glu Arg Val 
            20                  25                  30          


Cys Val Phe Gly Thr Gly Asp Leu Gly Arg Ser Leu Gly Leu Arg Leu 
        35                  40                  45              


Leu Gln Ala Gly Tyr Gly Val Val Phe Gly Ser Arg Arg Pro His Ser 
    50                  55                  60                  


Arg Ser Ser Leu Leu Pro His Gly Ala Gln Val Leu Gly His Ala Ala 
65                  70                  75                  80  


Ala Ala Gln Ser Ala His Leu Ile Phe Ile Ala Val Gln Arg Glu His 
                85                  90                  95      


Tyr Asp Phe Leu Val Pro Leu Ala Asn Gln Leu Lys Gly Lys Val Leu 
            100                 105                 110         


Val Asp Leu Ser Asn Asn Leu Arg Lys Asn Gln Tyr Pro Glu Ala Asn 
        115                 120                 125             


Ala Glu Tyr Leu Gln Ser Leu Val Pro Gly Ala Glu Val Val Lys Gly 
    130                 135                 140                 


Phe Asn Thr Leu Ser Ala Trp Ser Leu Gln Asn Gly Pro Ser Asp Ala 
145                 150                 155                 160 


Asn Arg Gln Val Tyr Ile Cys Gly Glu Ser Val Glu Ala Lys Gln Ala 
                165                 170                 175     


Val Ile Ala Val Ala Ile Lys Leu Gly Phe Ser Ala Leu Asp Arg Gly 
            180                 185                 190         


Phe Leu Ser Val Ala Arg Glu Leu Glu Asp Phe Pro Leu Gln Leu Phe 
        195                 200                 205             


Pro Gln Trp Arg Leu Pro Leu Arg Ile Ala Ile Gly Leu Ser Ala Ala 
    210                 215                 220                 


Phe Phe Phe Tyr Leu Leu Ile Arg Asp Ile Ile Tyr Ala Tyr Val Thr 
225                 230                 235                 240 


Gln Ser Lys Asp Ile Ser Phe Arg Ile Met Val Ser Leu Ala Asn Lys 
                245                 250                 255     


Val Cys Pro Ile Val Ser Leu Ile Met Leu Ser Leu Cys Tyr Leu Pro 
            260                 265                 270         


Gly Val Leu Ala Ser Phe Leu Gln Leu Tyr Arg Gly Thr Lys Tyr Leu 
        275                 280                 285             


Pro 
    


