                         SEQUENCE LISTING

<110>  Washington University in St. Louis
       Bu, Guojun
       Bu, Guojun
 
<120>  METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

<130>  60005161-0363

<150>  US 60/914,902
<151>  2007-04-30

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  55
<212>  PRT
<213>  Bos taurus

<400>  1

Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Lys Glu Lys Asn Gln Thr Lys Gln Glu Lys Gly Lys Lys Lys 
            20                  25                  30          


Lys Glu Arg Asp Leu Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg Ala 
        35                  40                  45              


Gly Ser Lys Lys Glu Glu Leu 
    50                  55  


<210>  2
<211>  57
<212>  PRT
<213>  Canis familiaris

<400>  2

Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Gln Glu Lys Asn Lys Thr Lys Gln Glu Lys Gly Lys Lys Lys 
            20                  25                  30          


Lys Glu Gly Val Pro Lys Ser Arg Ala Lys Val Val Gln Glu Asp Asn 
        35                  40                  45              


Arg Ala Gly Asn Lys Arg Glu Glu Leu 
    50                  55          


<210>  3
<211>  55
<212>  PRT
<213>  Homo sapiens

<400>  3

Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly Lys Lys Lys 
            20                  25                  30          


Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu Asn Arg Ala 
        35                  40                  45              


Gly Asn Lys Arg Glu Asp Leu 
    50                  55  


<210>  4
<211>  54
<212>  PRT
<213>  Mus musculus

<400>  4

Cys Ala Glu Val Thr Leu Glu Gly Gln Met Tyr Pro Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala Lys Lys Lys 
            20                  25                  30          


Glu Gly Asp Pro Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly 
        35                  40                  45              


Ser Arg Arg Glu Asp Leu 
    50                  


<210>  5
<211>  54
<212>  PRT
<213>  Mus musculus

<400>  5

Cys Ala Glu Val Thr Leu Glu Gly Gln Met Tyr Pro Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala Lys Lys Lys 
            20                  25                  30          


Glu Gly Asp Arg Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly 
        35                  40                  45              


Ser Arg Arg Glu Asp Leu 
    50                  


<210>  6
<211>  55
<212>  PRT
<213>  Pongo pygmaeus

<400>  6

Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly Lys Lys Lys 
            20                  25                  30          


Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Asp Asn Arg Ala 
        35                  40                  45              


Arg Asn Lys Arg Glu Asp Leu 
    50                  55  


<210>  7
<211>  54
<212>  PRT
<213>  Rattus norvegicus

<400>  7

Cys Ala Glu Val Thr Leu Glu Gly Gln Met Tyr Pro Gly Lys Gly Gly 
1               5                   10                  15      


Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Gly Lys Lys Lys 
            20                  25                  30          


Glu Gly Asp Pro Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly 
        35                  40                  45              


Ser Arg Arg Glu Asp Leu 
    50                  


<210>  8
<211>  55
<212>  PRT
<213>  Gallus gallus

<400>  8

Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly Lys Gly Ala 
1               5                   10                  15      


Asp Gly Ser Glu Lys Gly Arg Asn Lys Thr Lys Pro Glu Lys Ala Lys 
            20                  25                  30          


Lys Lys Lys Asp Ala Glu Lys Ser Lys Ser Ser His Glu Asp Asn Arg 
        35                  40                  45              


Ala Asn Gln Thr Glu Arg Gly 
    50                  55  


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys 
1               5                   10  


<210>  10
<211>  10
<212>  PRT
<213>  Canis familiaris

<400>  10

Lys Gly Gly Gly Ser Gln Glu Lys Asn Lys 
1               5                   10  


<210>  11
<211>  10
<212>  PRT
<213>  Bos taurus

<400>  11

Lys Gly Gly Gly Ser Lys Glu Lys Asn Gln 
1               5                   10  


<210>  12
<211>  10
<212>  PRT
<213>  Xenopus laevis

<400>  12

Lys Gly Gly Gly Ser Lys Glu Arg Gln Leu 
1               5                   10  


<210>  13
<211>  34
<212>  PRT
<213>  Homo sapiens

<400>  13

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
1               5                   10                  15      


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu 
            20                  25                  30          


Asn Arg 
        


<210>  14
<211>  38
<212>  PRT
<213>  Homo sapiens

<400>  14

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
1               5                   10                  15      


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu 
            20                  25                  30          


Asn Arg Ala Gly Asn Lys 
        35              


<210>  15
<211>  47
<212>  PRT
<213>  Homo sapiens

<400>  15

Gln Val Tyr Pro Gly Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr 
1               5                   10                  15      


Lys Gln Asp Lys Gly Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg 
            20                  25                  30          


Ser Ser Lys Glu Glu Asn Arg Ala Gly Asn Lys Arg Glu Asp Leu 
        35                  40                  45          


<210>  16
<211>  33
<212>  PRT
<213>  Mus musculus

<400>  16

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala 
1               5                   10                  15      


Lys Lys Lys Glu Gly Asp Pro Lys Pro Arg Ala Ser Lys Glu Asp Asn 
            20                  25                  30          


Arg 
    


<210>  17
<211>  33
<212>  PRT
<213>  Mus musculus

<400>  17

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala 
1               5                   10                  15      


Lys Lys Lys Glu Gly Asp Arg Lys Pro Arg Ala Ser Lys Glu Asp Asn 
            20                  25                  30          


Arg 
    


<210>  18
<211>  33
<212>  PRT
<213>  Mus musculus

<400>  18

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala 
1               5                   10                  15      


Lys Lys Lys Glu Gly Asp Arg Lys Pro Arg Ala Ser Lys Glu Asp Asn 
            20                  25                  30          


Arg 
    


<210>  19
<211>  37
<212>  PRT
<213>  Mus musculus

<400>  19

Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala Lys Lys Lys Glu 
1               5                   10                  15      


Gly Asp Arg Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly Ser 
            20                  25                  30          


Arg Arg Glu Asp Leu 
        35          


<210>  20
<211>  37
<212>  PRT
<213>  Mus musculus

<400>  20

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala 
1               5                   10                  15      


Lys Lys Lys Glu Gly Asp Pro Lys Pro Arg Ala Ser Lys Glu Asp Asn 
            20                  25                  30          


Arg Ala Gly Ser Arg 
        35          


<210>  21
<211>  37
<212>  PRT
<213>  Mus musculus

<400>  21

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala 
1               5                   10                  15      


Lys Lys Lys Glu Gly Asp Arg Lys Pro Arg Ala Ser Lys Glu Asp Asn 
            20                  25                  30          


Arg Ala Gly Ser Arg 
        35          


<210>  22
<211>  46
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Met Tyr Pro Gly Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr 
1               5                   10                  15      


Lys Pro Glu Lys Ala Lys Lys Lys Glu Gly Asp Pro Lys Pro Arg Ala 
            20                  25                  30          


Ser Lys Glu Asp Asn Arg Ala Gly Ser Arg Arg Glu Asp Leu 
        35                  40                  45      


<210>  23
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  23

Glu Gly Asp Pro Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly 
1               5                   10                  15      


Ser Arg 
        


<210>  24
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  24

Glu Gly Asp Arg Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly 
1               5                   10                  15      


Ser Arg 
        


<210>  25
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  25

Thr Lys Pro Glu Lys Ala Lys Lys Lys Glu Gly Asp Pro Lys Pro Arg 
1               5                   10                  15      


Ala Ser 
        


<210>  26
<211>  19
<212>  PRT
<213>  Mus musculus

<400>  26

Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys Ala 
1               5                   10                  15      


Lys Lys Lys 
            


<210>  27
<211>  18
<212>  PRT
<213>  Mus musculus

<400>  27

Thr Lys Pro Glu Lys Ala Lys Lys Lys Glu Gly Asp Arg Lys Pro Arg 
1               5                   10                  15      


Ala Ser 
        


<210>  28
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  28

Lys Glu Asp Asn Arg Ala Gly Ser Arg 
1               5                   


<210>  29
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  29

Lys Glu Lys Asn Lys Thr Lys Pro Glu Lys 
1               5                   10  


<210>  30
<211>  232
<212>  PRT
<213>  Bos taurus

<400>  30

Met Ala Ala Ser Gly Trp Ala Arg Ala Ala Val Ile Phe Leu Cys Ala 
1               5                   10                  15      


Cys Asp Leu Leu Leu Leu Leu Leu Leu Pro Pro Arg Ala Phe Ala Thr 
            20                  25                  30          


Glu Gly Pro Ala Glu Thr Pro Gly Glu Ala Thr Pro Pro Pro Arg Lys 
        35                  40                  45              


Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala Arg Leu 
    50                  55                  60                  


Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp Leu Pro 
65                  70                  75                  80  


Glu His Lys Arg Pro Ser Ala Pro Ile Asp Phe Ser Gln Ile Asp Pro 
                85                  90                  95      


Gly Lys Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly Lys Thr Leu 
            100                 105                 110         


Met Met Phe Val Thr Val Ser Gly Asn Pro Thr Glu Lys Glu Thr Glu 
        115                 120                 125             


Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn Tyr Asp 
    130                 135                 140                 


Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe Met Leu Arg 
145                 150                 155                 160 


Asp Gly Gly Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val Ser Gln Asp 
                165                 170                 175     


Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly Lys Gly 
            180                 185                 190         


Gly Gly Ser Lys Glu Lys Asn Gln Thr Lys Gln Glu Lys Gly Lys Lys 
        195                 200                 205             


Lys Lys Glu Arg Asp Leu Lys Pro Arg Ala Ser Lys Glu Asp Asn Arg 
    210                 215                 220                 


Ala Gly Ser Lys Lys Glu Glu Leu 
225                 230         


<210>  31
<211>  190
<212>  PRT
<213>  Canis familiaris

<400>  31

Met Gly Ser His Val Leu Val Thr Arg Val Ile Gly Ala Glu Ser Cys 
1               5                   10                  15      


Trp Arg Leu Gly Leu His Leu Lys Lys Asp Asp Asp Ile Glu Glu Gly 
            20                  25                  30          


Asp Leu Pro Glu His Lys Arg Pro Ser Ala Pro Ile Asp Phe Ser Gln 
        35                  40                  45              


Ile Asp Pro Gly Arg Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly 
    50                  55                  60                  


Lys Thr Leu Met Met Phe Val Thr Val Ser Gly Ser Pro Thr Glu Lys 
65                  70                  75                  80  


Glu Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala 
                85                  90                  95      


Asn Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe 
            100                 105                 110         


Met Leu Arg Asp Gly Ser Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val 
        115                 120                 125             


Ser Gln Asp Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro 
    130                 135                 140                 


Gly Lys Gly Gly Gly Ser Gln Glu Lys Asn Lys Thr Lys Gln Glu Lys 
145                 150                 155                 160 


Gly Lys Lys Lys Lys Glu Gly Val Pro Lys Ser Arg Ala Ala Lys Val 
                165                 170                 175     


Val Gln Glu Asp Asn Arg Ala Gly Asn Lys Arg Glu Glu Leu 
            180                 185                 190 


<210>  32
<211>  234
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Ala Ala Ser Arg Trp Ala Arg Lys Ala Val Val Leu Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Gly Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp 
65                  70                  75                  80  


Leu Pro Glu His Lys Arg Pro Ser Ala Pro Val Asp Phe Ser Lys Ile 
                85                  90                  95      


Asp Pro Ser Lys Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly Lys 
            100                 105                 110         


Thr Leu Met Met Phe Val Thr Val Ser Gly Ser Pro Thr Glu Lys Glu 
        115                 120                 125             


Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn 
    130                 135                 140                 


Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe Met 
145                 150                 155                 160 


Leu Arg Asp Gly Ser Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val Gly 
                165                 170                 175     


Gln Asp Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly 
            180                 185                 190         


Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
        195                 200                 205             


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu 
    210                 215                 220                 


Asn Arg Ala Gly Asn Lys Arg Glu Asp Leu 
225                 230                 


<210>  33
<211>  223
<212>  PRT
<213>  Gallus gallus

<400>  33

Met Ala Ala Ala Ala Arg Trp Ala Ala Leu Gly Leu Ala Leu Trp Leu 
1               5                   10                  15      


Cys Ala Ala Ala His Ala Glu Glu Pro Glu Gly Lys Arg Arg Ala Gly 
            20                  25                  30          


Pro Ala Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
        35                  40                  45              


Arg Leu Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp 
    50                  55                  60                  


Leu Pro Glu His Lys Arg Pro Pro Ala Pro Ile Asp Phe Ser Lys Ile 
65                  70                  75                  80  


Asp Pro Gly Lys Pro Glu Ser Ile Leu Lys Leu Thr Lys Lys Gly Lys 
                85                  90                  95      


Thr Leu Met Met Phe Val Thr Val Ser Gly Asn Pro Thr Glu Lys Glu 
            100                 105                 110         


Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn 
        115                 120                 125             


Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asn Arg Ala Ile Phe Met 
    130                 135                 140                 


Leu Arg Asp Gly Gly Tyr Ala Trp Glu Ile Lys Asp Phe Leu Ile Ser 
145                 150                 155                 160 


Gln Glu Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly 
                165                 170                 175     


Lys Gly Ala Asp Gly Ser Glu Lys Gly Arg Asn Lys Thr Lys Pro Glu 
            180                 185                 190         


Lys Ala Lys Lys Lys Lys Asp Ala Glu Lys Ser Lys Ser Ser His Glu 
        195                 200                 205             


Asp Asn Arg Ala Asn Gln Thr Glu Arg Gly Ser Met Thr Asp Thr 
    210                 215                 220             


<210>  34
<211>  224
<212>  PRT
<213>  Mus musculus

<400>  34

Met Ala Ala Ser Arg Trp Leu Arg Ala Val Leu Leu Phe Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Pro Pro Pro Asn Ala Tyr Ala Ala Asp Thr 
            20                  25                  30          


Pro Gly Glu Ala Thr Pro Pro Pro Arg Lys Lys Lys Asp Ile Arg Asp 
        35                  40                  45              


Tyr Asn Asp Ala Asp Met Ala Arg Leu Leu Glu Gln Trp Glu Lys Asp 
    50                  55                  60                  


Asp Asp Ile Glu Glu Gly Asp Leu Pro Glu His Lys Arg Pro Ser Ala 
65                  70                  75                  80  


Pro Ile Asp Phe Ser Lys Leu Asp Pro Gly Lys Pro Glu Ser Ile Leu 
                85                  90                  95      


Lys Met Thr Lys Lys Gly Lys Thr Leu Met Met Phe Val Thr Val Ser 
            100                 105                 110         


Gly Asn Pro Thr Glu Lys Glu Thr Glu Glu Ile Thr Ser Leu Trp Gln 
        115                 120                 125             


Gly Ser Leu Phe Asn Ala Asn Tyr Asp Val Gln Arg Phe Ile Val Gly 
    130                 135                 140                 


Ser Asp Arg Ala Ile Phe Met Leu Arg Asp Gly Ser Tyr Ala Trp Glu 
145                 150                 155                 160 


Ile Lys Asp Phe Leu Val Ser Gln Asp Arg Cys Ala Glu Val Thr Leu 
                165                 170                 175     


Glu Gly Gln Met Tyr Pro Gly Lys Gly Gly Gly Ser Lys Glu Lys Asn 
            180                 185                 190         


Lys Thr Lys Pro Glu Lys Ala Lys Lys Lys Glu Gly Asp Arg Lys Pro 
        195                 200                 205             


Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly Ser Arg Arg Glu Asp Leu 
    210                 215                 220                 


<210>  35
<211>  234
<212>  PRT
<213>  Pan troglodytes

<400>  35

Met Ala Ala Ser Arg Trp Ala Arg Lys Ala Val Val Leu Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Gly Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp 
65                  70                  75                  80  


Leu Pro Glu His Lys Arg Pro Ser Ala Pro Val Asp Phe Ser Lys Ile 
                85                  90                  95      


Asp Pro Ser Lys Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly Lys 
            100                 105                 110         


Thr Leu Met Met Phe Val Thr Val Ser Gly Ser Pro Thr Glu Lys Glu 
        115                 120                 125             


Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn 
    130                 135                 140                 


Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe Met 
145                 150                 155                 160 


Leu Arg Asp Gly Ser Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val Gly 
                165                 170                 175     


Gln Asp Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly 
            180                 185                 190         


Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
        195                 200                 205             


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Glu 
    210                 215                 220                 


Asn Arg Ala Gly Asn Lys Arg Glu Asp Leu 
225                 230                 


<210>  36
<211>  234
<212>  PRT
<213>  Pongo pygmaeus

<400>  36

Met Ala Ala Ser Ser Trp Ala Arg Lys Ala Val Val Val Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Leu Leu Leu Leu Pro Pro Pro Gly Ser Cys 
            20                  25                  30          


Ala Ala Glu Ala Ser Pro Gly Thr Pro Asp Glu Ser Thr Pro Pro Pro 
        35                  40                  45              


Arg Lys Lys Lys Lys Asp Ile Arg Asp Tyr Asn Asp Ala Asp Met Ala 
    50                  55                  60                  


Arg Leu Leu Glu Gln Trp Glu Lys Asp Asp Asp Ile Glu Glu Gly Asp 
65                  70                  75                  80  


Leu Pro Glu His Lys Arg Pro Ser Ala Pro Val Asp Phe Ser Lys Ile 
                85                  90                  95      


Asp Pro Ser Lys Pro Glu Ser Ile Leu Lys Met Thr Lys Lys Gly Lys 
            100                 105                 110         


Thr Leu Met Met Phe Val Thr Val Ser Gly Ser Pro Thr Glu Lys Glu 
        115                 120                 125             


Thr Glu Glu Ile Thr Ser Leu Trp Gln Gly Ser Leu Phe Asn Ala Asn 
    130                 135                 140                 


Tyr Asp Val Gln Arg Phe Ile Val Gly Ser Asp Arg Ala Ile Phe Met 
145                 150                 155                 160 


Leu Arg Asp Gly Asn Tyr Ala Trp Glu Ile Lys Asp Phe Leu Val Gly 
                165                 170                 175     


Gln Asp Arg Cys Ala Asp Val Thr Leu Glu Gly Gln Val Tyr Pro Gly 
            180                 185                 190         


Lys Gly Gly Gly Ser Lys Glu Lys Asn Lys Thr Lys Gln Asp Lys Gly 
        195                 200                 205             


Lys Lys Lys Lys Glu Gly Asp Leu Lys Ser Arg Ser Ser Lys Glu Asp 
    210                 215                 220                 


Asn Arg Ala Arg Asn Lys Arg Glu Asp Leu 
225                 230                 


<210>  37
<211>  224
<212>  PRT
<213>  Rattus norvegicus

<400>  37

Met Ala Ala Ser Ser Trp Leu Arg Ala Val Leu Leu Phe Leu Cys Ala 
1               5                   10                  15      


Ser Asp Leu Leu Leu Leu Ser Pro Pro Glu Ala Tyr Ala Thr Asp Thr 
            20                  25                  30          


Pro Gly Glu Ala Ile Thr Pro Pro Arg Lys Lys Lys Asp Ile Arg Asp 
        35                  40                  45              


Tyr Asn Asp Ala Asp Met Ala Arg Leu Leu Glu Gln Trp Glu Lys Asp 
    50                  55                  60                  


Asp Asp Ile Glu Glu Gly Asp Leu Pro Glu His Lys Arg Pro Ser Ala 
65                  70                  75                  80  


Pro Ile Asp Phe Ser Lys Leu Asp Pro Gly Lys Pro Glu Ser Ile Leu 
                85                  90                  95      


Lys Met Thr Lys Lys Gly Lys Thr Leu Met Met Phe Val Thr Ile Ser 
            100                 105                 110         


Gly Asn Pro Thr Glu Lys Glu Thr Glu Glu Ile Thr Ser Leu Trp Gln 
        115                 120                 125             


Gly Ser Leu Phe Asn Ala Asn Tyr Asp Val Gln Arg Phe Ile Val Gly 
    130                 135                 140                 


Ser Asp Arg Ala Ile Phe Met Leu Arg Asp Gly Ser Tyr Ala Trp Glu 
145                 150                 155                 160 


Ile Lys Asp Phe Leu Val Asn Gln Asp Arg Cys Ala Glu Val Thr Leu 
                165                 170                 175     


Glu Gly Gln Met Tyr Pro Gly Lys Gly Gly Gly Ser Lys Glu Lys Asn 
            180                 185                 190         


Lys Thr Lys Pro Glu Lys Gly Lys Lys Lys Glu Gly Asp Pro Lys Pro 
        195                 200                 205             


Arg Ala Ser Lys Glu Asp Asn Arg Ala Gly Ser Arg Arg Glu Asp Leu 
    210                 215                 220                 


<210>  38
<211>  158
<212>  PRT
<213>  Xenopus laevis

<400>  38

Met Gly Arg Ser Arg Ser Arg Ser Pro Glu Arg Arg Arg Glu Arg Arg 
1               5                   10                  15      


Arg Ser Arg Ser Ala Ser Arg Glu Arg Glu Arg Arg Arg Arg Glu Arg 
            20                  25                  30          


Ser Arg Ser Arg Glu Arg Arg Arg Ser Arg Ser Arg Ser Pro His Arg 
        35                  40                  45              


Arg Arg Ser Arg Ser Pro Arg Arg His Arg Ser Ser Ser Ile Ser Pro 
    50                  55                  60                  


Ser Arg Leu Lys Asp Arg Arg Asp Asp Asp Lys Lys Glu Pro Lys Glu 
65                  70                  75                  80  


Ser Lys Gly Gly Gly Ser Lys Glu Arg Gln Leu Ala Ala Glu Asp Leu 
                85                  90                  95      


Glu Gly Lys Thr Glu Glu Glu Ile Glu Met Met Lys Leu Met Gly Phe 
            100                 105                 110         


Ala Ser Phe Asp Ser Ser Lys Gly Lys Lys Thr Asp Gly Ser Val Asn 
        115                 120                 125             


Ala Tyr Ala Ile Asn Val Ser Gln Lys Arg Lys Tyr Arg Gln Tyr Met 
    130                 135                 140                 


Asn Arg Lys Gly Gly Phe Asn Arg Pro Leu Asp Phe Val Ala 
145                 150                 155             


