                         SEQUENCE LISTING

<110>  AGENT/REPRESENTATIVE: Greenlee, Winner and Sullivan, P.C.; 
       Customer No. 23713
       The Board of Trustees of the University of Illinois
       APPLICANT:  The Board of Trustees of the University of 
       Illinois
       HERGENROTHER, Paul J.
       PUTT, Karson S.
       SANDHORST, Joseph S.
       PETERSON, Quinn P.
       FAKO, Valerie
 
<120>  COMPOSITIONS AND METHODS INCLUDING CELL DEATH INDUCERS AND 
       PROCASPASE ACTIVATION

<130>  GWS 73-07 WO

<140>  PCT/US ______________to be assigned
<141>  2008-04-25

<150>  US 60/914,592
<151>  2007-04-27

<160>  27    

<170>  PatentIn version 3.5

<210>  1
<211>  834
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(834)
<223>  Procaspase-3; with amino acid DDD wild-type safety catch sequence
       (ACCESSION Number   NM_004346)

<400>  1
atg gag aac act gaa aac tca gtg gat tca aaa tcc att aaa aat ttg         48
Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu           
1               5                   10                  15                

gaa cca aag atc ata cat gga agc gaa tca atg gac tct gga ata tcc         96
Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser           
            20                  25                  30                    

ctg gac aac agt tat aaa atg gat tat cct gag atg ggt tta tgt ata        144
Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile           
        35                  40                  45                        

ata att aat aat aag aat ttt cat aaa agc act gga atg aca tct cgg        192
Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg           
    50                  55                  60                            

tct ggt aca gat gtc gat gca gca aac ctc agg gaa aca ttc aga aac        240
Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn           
65                  70                  75                  80            

ttg aaa tat gaa gtc agg aat aaa aat gat ctt aca cgt gaa gaa att        288
Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile           
                85                  90                  95                

gtg gaa ttg atg cgt gat gtt tct aaa gaa gat cac agc aaa agg agc        336
Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser           
            100                 105                 110                   

agt ttt gtt tgt gtg ctt ctg agc cat ggt gaa gaa gga ata att ttt        384
Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe           
        115                 120                 125                       

gga aca aat gga cct gtt gac ctg aaa aaa ata aca aac ttt ttc aga        432
Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg           
    130                 135                 140                           

ggg gat cgt tgt aga agt cta act gga aaa ccc aaa ctt ttc att att        480
Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile           
145                 150                 155                 160           

cag gcc tgc cgt ggt aca gaa ctg gac tgt ggc att gag aca gac agt        528
Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser           
                165                 170                 175               

ggt gtt gat gat gac atg gcg tgt cat aaa ata cca gtg gag gcc gac        576
Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp           
            180                 185                 190                   

ttc ttg tat gca tac tcc aca gca cct ggt tat tat tct tgg cga aat        624
Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn           
        195                 200                 205                       

tca aag gat ggc tcc tgg ttc atc cag tcg ctt tgt gcc atg ctg aaa        672
Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys           
    210                 215                 220                           

cag tat gcc gac aag ctt gaa ttt atg cac att ctt acc cgg gtt aac        720
Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn           
225                 230                 235                 240           

cga aag gtg gca aca gaa ttt gag tcc ttt tcc ttt gac gct act ttt        768
Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe           
                245                 250                 255               

cat gca aag aaa cag att cca tgt att gtt tcc atg ctc aca aaa gaa        816
His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu           
            260                 265                 270                   

ctc tat ttt tat cac taa                                                834
Leu Tyr Phe Tyr His                                                       
        275                                                               


<210>  2
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  3
<211>  1326
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (50)..(880)
<223>  Procaspase-3; with amino acid DDD to ADD safety catch mutant 
       sequence

<220>
<221>  misc_feature
<222>  (934)..(934)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (939)..(939)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (954)..(954)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (982)..(982)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (988)..(988)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1000)..(1000)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1024)..(1024)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1036)..(1036)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1045)..(1045)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1051)..(1051)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1053)..(1053)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1063)..(1063)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1071)..(1071)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1075)..(1075)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1079)..(1079)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1086)..(1086)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1093)..(1093)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1095)..(1095)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1100)..(1100)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1104)..(1104)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1106)..(1106)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1125)..(1125)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1140)..(1140)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1146)..(1146)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1149)..(1150)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1155)..(1155)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1157)..(1157)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1159)..(1159)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1190)..(1190)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1199)..(1200)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1209)..(1209)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1212)..(1212)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1223)..(1224)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1233)..(1233)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1235)..(1235)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1238)..(1238)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1241)..(1241)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1246)..(1246)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1256)..(1256)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1259)..(1259)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1262)..(1262)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1273)..(1273)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1276)..(1276)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1282)..(1282)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1285)..(1285)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1288)..(1288)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1294)..(1294)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1299)..(1299)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1302)..(1302)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1306)..(1306)
<223>  n is a, c, g, t or u

<400>  3
gtacattccc tctgaataat tttgtttact ttaagaagga gatatacat atg gag aac       58
                                                      Met Glu Asn         
                                                      1                   

act gaa aac tca gtg gat tca aaa tcc att aaa aat ttg gaa cca aag        106
Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu Glu Pro Lys           
    5                   10                  15                            

atc ata cat gga agc gaa tca atg gac tct gga ata tcc ctg gac aac        154
Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser Leu Asp Asn           
20                  25                  30                  35            

agt tat aaa atg gat tat cct gag atg ggt tta tgt ata ata att aat        202
Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile Ile Ile Asn           
                40                  45                  50                

aat aag aat ttt cat aaa agc act gga atg aca tct cgg tct ggt aca        250
Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg Ser Gly Thr           
            55                  60                  65                    

gat gtc gat gca gca aac ctc agg gaa aca ttc aga aac ttg aaa tat        298
Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn Leu Lys Tyr           
        70                  75                  80                        

gaa gtc agg aat aaa aat gat ctt aca cgt gaa gaa att gtg gaa ttg        346
Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile Val Glu Leu           
    85                  90                  95                            

atg cgt gat gtt tct aaa gaa gat cac agc aaa agg agc agt ttt gtt        394
Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser Ser Phe Val           
100                 105                 110                 115           

tgt gtg ctt ctg agc cat ggt gaa gaa gga ata att ttt gga aca aat        442
Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe Gly Thr Asn           
                120                 125                 130               

gga cct gtt gac ctg aaa aaa ata aca aac ttt ttc aga ggg gat cgt        490
Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg Gly Asp Arg           
            135                 140                 145                   

tgt aga agt cta act gga aaa ccc aaa ctt ttc att att cag gcc tgc        538
Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile Gln Ala Cys           
        150                 155                 160                       

cgt ggt aca gaa ctg gac tgt ggc att gag aca gac agt ggt gtt gcg        586
Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser Gly Val Ala           
    165                 170                 175                           

gat gac atg gcg tgt cat aaa ata cca gtg gag gcc gac ttc ttg tat        634
Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp Phe Leu Tyr           
180                 185                 190                 195           

gca tac tcc aca gca cct ggt tat tat tct tgg cga aat tca aag gat        682
Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn Ser Lys Asp           
                200                 205                 210               

ggc tcc tgg ttc atc cag tcg ctt tgt gcc atg ctg aaa cag tat gcc        730
Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys Gln Tyr Ala           
            215                 220                 225                   

gac aag ctt gaa ttt atg cac att ctt acc cgg gtt aac cga aag gtg        778
Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn Arg Lys Val           
        230                 235                 240                       

gca aca gaa ttt gag tcc ttt tcc ttt gac gct act ttt cat gca aag        826
Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe His Ala Lys           
    245                 250                 255                           

aaa cag att cca tgt att gtt tcc atg ctc aca aaa gaa ctc tat ttt        874
Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu Leu Tyr Phe           
260                 265                 270                 275           

tat cac ctcgagcacc accaccacca ccactgagat ccggctgcta caagccgaaa         930
Tyr His                                                                   
                                                                          

gganctgant tggctgctgc cccnctgacc atactacata ccccctgggg cnctaacngg      990

tctggggggn tttttgctga aggagacttt tccngatggc aatggnaccc cctgnccgcc     1050

ntnacccggc ggngggggtt ncccnacgng acctancttg ccngncctan cccncncttc     1110

cttttccttc ttccnccgtt ccggttcccn cagctnaann ggggncntng gtccattggc     1170

ttcgcccccc caaactgttn gggggtccnn ggccccccna angtttccct tanngacccc     1230

ttnanggnct ntcccngacc cccccnccnt tnttttaagg tcnccncccg gnaanggnta     1290

aatnccttna ancccntggg ttgggggccc tttttt                               1326


<210>  4
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Ala Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  5
<211>  1398
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (51)..(881)
<223>  Procaspase-3; with amino acid DDD to DAD safety catch mutant 
       sequence

<220>
<221>  misc_feature
<222>  (923)..(923)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (933)..(933)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (942)..(942)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (963)..(963)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (978)..(978)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (991)..(991)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (994)..(994)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1022)..(1022)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1031)..(1031)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1033)..(1033)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1045)..(1045)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1047)..(1047)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1061)..(1061)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1067)..(1067)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1069)..(1069)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1076)..(1076)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1091)..(1091)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1095)..(1095)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1098)..(1098)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1102)..(1102)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1105)..(1105)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1112)..(1112)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1116)..(1116)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1122)..(1123)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1126)..(1126)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1129)..(1129)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1134)..(1134)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1139)..(1139)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1144)..(1144)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1148)..(1148)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1150)..(1150)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1158)..(1158)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1175)..(1175)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1180)..(1180)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1190)..(1190)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1196)..(1196)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1200)..(1200)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1202)..(1202)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1206)..(1207)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1215)..(1215)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1224)..(1224)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1231)..(1231)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1238)..(1238)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1245)..(1245)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1249)..(1249)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1273)..(1273)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1276)..(1276)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1284)..(1284)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1299)..(1299)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1309)..(1309)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1312)..(1312)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1319)..(1319)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1321)..(1321)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1325)..(1325)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1328)..(1328)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1335)..(1335)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1337)..(1337)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1345)..(1345)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1348)..(1348)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1355)..(1355)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1358)..(1358)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1364)..(1364)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1369)..(1369)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1376)..(1376)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1379)..(1379)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1387)..(1387)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1390)..(1390)
<223>  n is a, c, g, t or u

<400>  5
cgtacattcc ctctgaataa ttttgtttac tttaagaagg agatatacat atg gag          56
                                                       Met Glu            
                                                       1                  

aac act gaa aac tca gtg gat tca aaa tcc att aaa aat ttg gaa cca        104
Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu Glu Pro           
        5                   10                  15                        

aag atc ata cat gga agc gaa tca atg gac tct gga ata tcc ctg gac        152
Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser Leu Asp           
    20                  25                  30                            

aac agt tat aaa atg gat tat cct gag atg ggt tta tgt ata ata att        200
Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile Ile Ile           
35                  40                  45                  50            

aat aat aag aat ttt cat aaa agc act gga atg aca tct cgg tct ggt        248
Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg Ser Gly           
                55                  60                  65                

aca gat gtc gat gca gca aac ctc agg gaa aca ttc aga aac ttg aaa        296
Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn Leu Lys           
            70                  75                  80                    

tat gaa gtc agg aat aaa aat gat ctt aca cgt gaa gaa att gtg gaa        344
Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile Val Glu           
        85                  90                  95                        

ttg atg cgt gat gtt tct aaa gaa gat cac agc aaa agg agc agt ttt        392
Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser Ser Phe           
    100                 105                 110                           

gtt tgt gtg ctt ctg agc cat ggt gaa gaa gga ata att ttt gga aca        440
Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe Gly Thr           
115                 120                 125                 130           

aat gga cct gtt gac ctg aaa aaa ata aca aac ttt ttc aga ggg gat        488
Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg Gly Asp           
                135                 140                 145               

cgt tgt aga agt cta act gga aaa ccc aaa ctt ttc att att cag gcc        536
Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile Gln Ala           
            150                 155                 160                   

tgc cgt ggt aca gaa ctg gac tgt ggc att gag aca gac agt ggt gtt        584
Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser Gly Val           
        165                 170                 175                       

gat gct gac atg gcg tgt cat aaa ata cca gtg gag gcc gac ttc ttg        632
Asp Ala Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp Phe Leu           
    180                 185                 190                           

tat gca tac tcc aca gca cct ggt tat tat tct tgg cga aat tca aag        680
Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn Ser Lys           
195                 200                 205                 210           

gat ggc tcc tgg ttc atc cag tcg ctt tgt gcc atg ctg aaa cag tat        728
Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys Gln Tyr           
                215                 220                 225               

gcc gac aag ctt gaa ttt atg cac att ctt acc cgg gtt aac cga aag        776
Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn Arg Lys           
            230                 235                 240                   

gtg gca aca gaa ttt gag tcc ttt tcc ttt gac gct act ttt cat gca        824
Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe His Ala           
        245                 250                 255                       

aag aaa cag att cca tgt att gtt tcc atg ctc aca aaa gaa ctc tat        872
Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu Leu Tyr           
    260                 265                 270                           

ttt tat cac ctcgagcacc accaccacca ccactgagat ccggctgcta                921
Phe Tyr His                                                               
275                                                                       

cnaagcccga angaagctga nttggctgct gcccccgctg ancaataact agcatanccc      981

cttggggccn ctnaacgggt ctggaggggt ttttgctgaa nggggacctn tntccggatt     1041

ggcnanggga ccccccctgn accgcncntt aaccncgcgg ggggggggtn cccncanggg     1101

nccnctacct ngccngcccc nnacnccncc ccnttccntt ctncctncnt tcccccngtt     1161

cccgggtttc ccgnagccna aacgggggnc ccttnggtnc nattnngctt tccncccccc     1221

ccnaaacttn taggggnggt cccngggncc ccccgaaagg tttccccttg cnggnccccc     1281

ttnaaggact ttcccagnaa cccccccncg nccctttntn aggntcnccc cccngnaaag     1341

ggtnaantcc gttnaanccc ttnggctngg gggcnccntt tttttnttnc ccccccc        1398


<210>  6
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Ala Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  7
<211>  1316
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (51)..(881)
<223>  Procaspase-3; with amino acid DDD to DAD safety catch mutant 
       sequence

<220>
<221>  misc_feature
<222>  (914)..(914)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (942)..(942)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (958)..(958)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (982)..(982)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (986)..(986)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (988)..(988)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1006)..(1006)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1026)..(1026)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1032)..(1032)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1038)..(1038)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1040)..(1041)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1051)..(1051)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1062)..(1062)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1067)..(1067)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1073)..(1073)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1097)..(1097)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1101)..(1101)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1106)..(1106)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1108)..(1108)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1114)..(1114)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1118)..(1118)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1123)..(1123)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1129)..(1129)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1134)..(1134)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1148)..(1149)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1151)..(1151)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1154)..(1154)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1156)..(1157)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1173)..(1173)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1193)..(1193)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1200)..(1200)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1206)..(1206)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1215)..(1215)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1228)..(1230)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1232)..(1232)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1247)..(1247)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1250)..(1250)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1261)..(1261)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1263)..(1264)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1272)..(1272)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1275)..(1275)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1277)..(1277)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1286)..(1286)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1289)..(1289)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1291)..(1292)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1294)..(1294)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1299)..(1299)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1301)..(1301)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1304)..(1304)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1307)..(1307)
<223>  n is a, c, g, t or u

<220>
<221>  misc_feature
<222>  (1316)..(1316)
<223>  n is a, c, g, t or u

<400>  7
cgtacattcc ctctgaataa ttttgtttac tttaagaagg agatatacat atg gag          56
                                                       Met Glu            
                                                       1                  

aac act gaa aac tca gtg gat tca aaa tcc att aaa aat ttg gaa cca        104
Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu Glu Pro           
        5                   10                  15                        

aag atc ata cat gga agc gaa tca atg gac tct gga ata tcc ctg gac        152
Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser Leu Asp           
    20                  25                  30                            

aac agt tat aaa atg gat tat cct gag atg ggt tta tgt ata ata att        200
Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile Ile Ile           
35                  40                  45                  50            

aat aat aag aat ttt cat aaa agc act gga atg aca tct cgg tct ggt        248
Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg Ser Gly           
                55                  60                  65                

aca gat gtc gat gca gca aac ctc agg gaa aca ttc aga aac ttg aaa        296
Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn Leu Lys           
            70                  75                  80                    

tat gaa gtc agg aat aaa aat gat ctt aca cgt gaa gaa att gtg gaa        344
Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile Val Glu           
        85                  90                  95                        

ttg atg cgt gat gtt tct aaa gaa gat cac agc aaa agg agc agt ttt        392
Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser Ser Phe           
    100                 105                 110                           

gtt tgt gtg ctt ctg agc cat ggt gaa gaa gga ata att ttt gga aca        440
Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe Gly Thr           
115                 120                 125                 130           

aat gga cct gtt gac ctg aaa aaa ata aca aac ttt ttc aga ggg gat        488
Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg Gly Asp           
                135                 140                 145               

cgt tgt aga agt cta act gga aaa ccc aaa ctt ttc att att cag gcc        536
Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile Gln Ala           
            150                 155                 160                   

tgc cgt ggt aca gaa ctg gac tgt ggc att gag aca gac agt ggt gtt        584
Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser Gly Val           
        165                 170                 175                       

gat gat gcc atg gcg tgt cat aaa ata cca gtg gag gcc gac ttc ttg        632
Asp Asp Ala Met Ala Cys His Lys Ile Pro Val Glu Ala Asp Phe Leu           
    180                 185                 190                           

tat gca tac tcc aca gca cct ggt tat tat tct tgg cga aat tca aag        680
Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn Ser Lys           
195                 200                 205                 210           

gat ggc tcc tgg ttc atc cag tcg ctt tgt gcc atg ctg aaa cag tat        728
Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys Gln Tyr           
                215                 220                 225               

gcc gac aag ctt gaa ttt atg cac att ctt acc cgg gtt aac cga aag        776
Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn Arg Lys           
            230                 235                 240                   

gtg gca aca gaa ttt gag tcc ttt tcc ttt gac gct act ttt cat gca        824
Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe His Ala           
        245                 250                 255                       

aag aaa cag att cca tgt att gtt tcc atg ctc aca aaa gaa ctc tat        872
Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu Leu Tyr           
    260                 265                 270                           

ttt tat cac ctcgagcacc cccccaccac cactgagatc cgnctgctac                921
Phe Tyr His                                                               
275                                                                       

aaagcccgaa aggaagctga nttggctgct gcccccnctg accataccta gcatacccct      981

ngggncncta acgggtctgg ggggnttttg ctgaaggggg acctnttccg natggcnann     1041

ggaccccccn gtaccgccct naaccngcgg gngggggttc ccccacggac cctacntgcn     1101

gcccnanccc ccncttncct tntcctcntt ccnccgtccg gttcccnnan ctnanngggc     1161

ccttggtcca tnggcttcgc cccccccaaa cnttagggng gtccngggcc cccnaaaggt     1221

tcccttnnng ncccctttaa ggactntcnc ggaccccccn cnnctttttt nagntncctc     1281

cctgnaangn ntnaaatncn ttnaanccct gggcn                                1316


<210>  8
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Ala Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  9
<211>  277
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(277)
<223>  Procaspase-3; with amino acid DDD wild-type safety catch sequence
       (ACCESSION Number   NM_004346)

<400>  9

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  10
<211>  277
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(277)
<223>  Procaspase-3; with amino acid DDD to ADD safety catch mutant 
       sequence

<400>  10

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Ala Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  11
<211>  277
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(277)
<223>  Procaspase-3; with amino acid DDD to DAD safety catch mutant 
       sequence

<400>  11

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Ala Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Xaa Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  12
<211>  277
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(277)
<223>  Procaspase-3; with amino acid DDD to DAD safety catch mutant 
       sequence

<400>  12

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Ala Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  13
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligo

<400>  13
gacagacagt ggtgttgcgg atgacatggc gtgtcataaa atacc                       45


<210>  14
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligo

<400>  14
gacagacagt ggtgttgatg ctgacatggc gtgtcataaa atacc                       45


<210>  15
<211>  45
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic oligo

<400>  15
gacagacagt ggtgttgatg atgccatggc gtgtcataaa atacc                       45


<210>  16
<211>  912
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(912)
<223>  Procaspase-7 with amino acid DTD wild-type safety catch sequence       (Accession Number  NM_001227)

<400>  16
atg gca gat gat cag ggc tgt att gaa gag cag ggg gtt gag gat tca         48
Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser           
1               5                   10                  15                

gca aat gaa gat tca gtg gat gct aag cca gac cgg tcc tcg ttt gta         96
Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val           
            20                  25                  30                    

ccg tcc ctc ttc agt aag aag aag aaa aat gtc acc atg cga tcc atc        144
Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile           
        35                  40                  45                        

aag acc acc cgg gac cga gtg cct aca tat cag tac aac atg aat ttt        192
Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe           
    50                  55                  60                            

gaa aag ctg ggc aaa tgc atc ata ata aac aac aag aac ttt gat aaa        240
Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys           
65                  70                  75                  80            

gtg aca ggt atg ggc gtt cga aac gga aca gac aaa gat gcc gag gcg        288
Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala           
                85                  90                  95                

ctc ttc aag tgc ttc cga agc ctg ggt ttt gac gtg att gtc tat aat        336
Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn           
            100                 105                 110                   

gac tgc tct tgt gcc aag atg caa gat ctg ctt aaa aaa gct tct gaa        384
Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu           
        115                 120                 125                       

gag gac cat aca aat gcc gcc tgc ttc gcc tgc atc ctc tta agc cat        432
Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His           
    130                 135                 140                           

gga gaa gaa aat gta att tat ggg aaa gat ggt gtc aca cca ata aag        480
Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys           
145                 150                 155                 160           

gat ttg aca gcc cac ttt agg ggg gat aga tgc aaa acc ctt tta gag        528
Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu           
                165                 170                 175               

aaa ccc aaa ctc ttc ttc att cag gct tgc cga ggg acc gag ctt gat        576
Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp           
            180                 185                 190                   

gat ggc atc cag gcc gac tcg ggg ccc atc aat gac aca gat gct aat        624
Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn           
        195                 200                 205                       

cct cga tac aag atc cca gtg gaa gct gac ttc ctc ttc gcc tat tcc        672
Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser           
    210                 215                 220                           

acg gtt cca ggc tat tac tcg tgg agg agc cca gga aga ggc tcc tgg        720
Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp           
225                 230                 235                 240           

ttt gtg caa gcc ctc tgc tcc atc ctg gag gag cac gga aaa gac ctg        768
Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu           
                245                 250                 255               

gaa atc atg cag atc ctc acc agg gtg aat gac aga gtt gcc agg cac        816
Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His           
            260                 265                 270                   

ttt gag tct cag tct gat gac cca cac ttc cat gag aag aag cag atc        864
Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile           
        275                 280                 285                       

ccc tgt gtg gtc tcc atg ctc acc aag gaa ctc tac ttc agt caa tag        912
Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln               
    290                 295                 300                           


<210>  17
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  18
<211>  912
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(912)
<223>  Procaspase-7 DDD wild-type safety catch sequence

<400>  18
atg gca gat gat cag ggc tgt att gaa gag cag ggg gtt gag gat tca         48
Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser           
1               5                   10                  15                

gca aat gaa gat tca gtg gat gct aag cca gac cgg tcc tcg ttt gta         96
Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val           
            20                  25                  30                    

ccg tcc ctc ttc agt aag aag aag aaa aat gtc acc atg cga tcc atc        144
Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile           
        35                  40                  45                        

aag acc acc cgg gac cga gtg cct aca tat cag tac aac atg aat ttt        192
Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe           
    50                  55                  60                            

gaa aag ctg ggc aaa tgc atc ata ata aac aac aag aac ttt gat aaa        240
Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys           
65                  70                  75                  80            

gtg aca ggt atg ggc gtt cga aac gga aca gac aaa gat gcc gag gcg        288
Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala           
                85                  90                  95                

ctc ttc aag tgc ttc cga agc ctg ggt ttt gac gtg att gtc tat aat        336
Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn           
            100                 105                 110                   

gac tgc tct tgt gcc aag atg caa gat ctg ctt aaa aaa gct tct gaa        384
Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu           
        115                 120                 125                       

gag gac cat aca aat gcc gcc tgc ttc gcc tgc atc ctc tta agc cat        432
Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His           
    130                 135                 140                           

gga gaa gaa aat gta att tat ggg aaa gat ggt gtc aca cca ata aag        480
Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys           
145                 150                 155                 160           

gat ttg aca gcc cac ttt agg ggg gat aga tgc aaa acc ctt tta gag        528
Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu           
                165                 170                 175               

aaa ccc aaa ctc ttc ttc att cag gct tgc cga ggg acc gag ctt gat        576
Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp           
            180                 185                 190                   

gat ggc atc cag gcc gac tcg ggg ccc atc aat gac gca gat gct aat        624
Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Ala Asp Ala Asn           
        195                 200                 205                       

cct cga tac aag atc cca gtg gaa gct gac ttc ctc ttc gcc tat tcc        672
Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser           
    210                 215                 220                           

acg gtt cca ggc tat tac tcg tgg agg agc cca gga aga ggc tcc tgg        720
Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp           
225                 230                 235                 240           

ttt gtg caa gcc ctc tgc tcc atc ctg gag gag cac gga aaa gac ctg        768
Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu           
                245                 250                 255               

gaa atc atg cag atc ctc acc agg gtg aat gac aga gtt gcc agg cac        816
Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His           
            260                 265                 270                   

ttt gag tct cag tct gat gac cca cac ttc cat gag aag aag cag atc        864
Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile           
        275                 280                 285                       

ccc tgt gtg gtc tcc atg ctc acc aag gaa ctc tac ttc agt caa tag        912
Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln               
    290                 295                 300                           


<210>  19
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  19

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Ala Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  20
<211>  936
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(936)
<223>  Procaspase-7 DTD wild-type safety catch, active site C to A 
       mutant sequence

<400>  20
atg gca gat gat cag ggc tgt att gaa gag cag ggg gtt gag gat tca         48
Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser           
1               5                   10                  15                

gca aat gaa gat tca gtg gat gct aag cca gac cgg tcc tcg ttt gta         96
Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val           
            20                  25                  30                    

ccg tcc ctc ttc agt aag aag aag aaa aat gtc acc atg cga tcc atc        144
Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile           
        35                  40                  45                        

aag acc acc cgg gac cga gtg cct aca tat cag tac aac atg aat ttt        192
Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe           
    50                  55                  60                            

gaa aag ctg ggc aaa tgc atc ata ata aac aac aag aac ttt gat aaa        240
Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys           
65                  70                  75                  80            

gtg aca ggt atg ggc gtt cga aac gga aca gac aaa gat gcc gag gcg        288
Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala           
                85                  90                  95                

ctc ttc aag tgc ttc cga agc ctg ggt ttt gac gtg att gtc tat aat        336
Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn           
            100                 105                 110                   

gac tgc tct tgt gcc aag atg caa gat ctg ctt aaa aaa gct tct gaa        384
Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu           
        115                 120                 125                       

gag gac cat aca aat gcc gcc tgc ttc gcc tgc atc ctc tta agc cat        432
Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His           
    130                 135                 140                           

gga gaa gaa aat gta att tat ggg aaa gat ggt gtc aca cca ata aag        480
Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys           
145                 150                 155                 160           

gat ttg aca gcc cac ttt agg ggg gat aga tgc aaa acc ctt tta gag        528
Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu           
                165                 170                 175               

aaa ccc aaa ctc ttc ttc att cag gct gcc cga ggg acc gag ctt gat        576
Lys Pro Lys Leu Phe Phe Ile Gln Ala Ala Arg Gly Thr Glu Leu Asp           
            180                 185                 190                   

gat ggc atc cag gcc gac tcg ggg ccc atc aat gac aca gat gct aat        624
Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn           
        195                 200                 205                       

cct cga tac aag atc cca gtg gaa gct gac ttc ctc ttc gcc tat tcc        672
Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser           
    210                 215                 220                           

acg gtt cca ggc tat tac tcg tgg agg agc cca gga aga ggc tcc tgg        720
Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp           
225                 230                 235                 240           

ttt gtg caa gcc ctc tgc tcc atc ctg gag gag cac gga aaa gac ctg        768
Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu           
                245                 250                 255               

gaa atc atg cag atc ctc acc agg gtg aat gac aga gtt gcc agg cac        816
Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His           
            260                 265                 270                   

ttt gag tct cag tct gat gac cca cac ttc cat gag aag aag cag atc        864
Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile           
        275                 280                 285                       

ccc tgt gtg gtc tcc atg ctc acc aag gaa ctc tac ttc agt caa ctc        912
Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln Leu           
    290                 295                 300                           

gag cac cac cac cac cac cac tga                                        936
Glu His His His His His His                                               
305                 310                                                   


<210>  21
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  21

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Ala Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln Leu 
    290                 295                 300                 


Glu His His His His His His 
305                 310     


<210>  22
<211>  936
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(936)
<223>  Procaspase-7 DDD wild-type safety catch, active site C to A 
       mutant sequence

<400>  22
atg gca gat gat cag ggc tgt att gaa gag cag ggg gtt gag gat tca         48
Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser           
1               5                   10                  15                

gca aat gaa gat tca gtg gat gct aag cca gac cgg tcc tcg ttt gta         96
Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val           
            20                  25                  30                    

ccg tcc ctc ttc agt aag aag aag aaa aat gtc acc atg cga tcc atc        144
Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile           
        35                  40                  45                        

aag acc acc cgg gac cga gtg cct aca tat cag tac aac atg aat ttt        192
Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe           
    50                  55                  60                            

gaa aag ctg ggc aaa tgc atc ata ata aac aac aag aac ttt gat aaa        240
Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys           
65                  70                  75                  80            

gtg aca ggt atg ggc gtt cga aac gga aca gac aaa gat gcc gag gcg        288
Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala           
                85                  90                  95                

ctc ttc aag tgc ttc cga agc ctg ggt ttt gac gtg att gtc tat aat        336
Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn           
            100                 105                 110                   

gac tgc tct tgt gcc aag atg caa gat ctg ctt aaa aaa gct tct gaa        384
Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu           
        115                 120                 125                       

gag gac cat aca aat gcc gcc tgc ttc gcc tgc atc ctc tta agc cat        432
Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His           
    130                 135                 140                           

gga gaa gaa aat gta att tat ggg aaa gat ggt gtc aca cca ata aag        480
Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys           
145                 150                 155                 160           

gat ttg aca gcc cac ttt agg ggg gat aga tgc aaa acc ctt tta gag        528
Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu           
                165                 170                 175               

aaa ccc aaa ctc ttc ttc att cag gct gcc cga ggg acc gag ctt gat        576
Lys Pro Lys Leu Phe Phe Ile Gln Ala Ala Arg Gly Thr Glu Leu Asp           
            180                 185                 190                   

gat ggc atc cag gcc gac tcg ggg ccc atc aat gac gca gat gct aat        624
Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Ala Asp Ala Asn           
        195                 200                 205                       

cct cga tac aag atc cca gtg gaa gct gac ttc ctc ttc gcc tat tcc        672
Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser           
    210                 215                 220                           

acg gtt cca ggc tat tac tcg tgg agg agc cca gga aga ggc tcc tgg        720
Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp           
225                 230                 235                 240           

ttt gtg caa gcc ctc tgc tcc atc ctg gag gag cac gga aaa gac ctg        768
Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu           
                245                 250                 255               

gaa atc atg cag atc ctc acc agg gtg aat gac aga gtt gcc agg cac        816
Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His           
            260                 265                 270                   

ttt gag tct cag tct gat gac cca cac ttc cat gag aag aag cag atc        864
Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile           
        275                 280                 285                       

ccc tgt gtg gtc tcc atg ctc acc aag gaa ctc tac ttc agt caa ctc        912
Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln Leu           
    290                 295                 300                           

gag cac cac cac cac cac cac tga                                        936
Glu His His His His His His                                               
305                 310                                                   


<210>  23
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  23

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Ala Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Ala Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln Leu 
    290                 295                 300                 


Glu His His His His His His 
305                 310     


<210>  24
<211>  303
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(303)
<223>  Procaspase-7 with amino acid DTD wild-type safety catch sequence       (Accession Number  NM_001227)

<400>  24

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  25
<211>  303
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(303)
<223>  Procaspase-7 DDD wild-type safety catch sequence

<400>  25

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Asp Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  26
<211>  303
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(303)
<223>  Procaspase-7 DTD wild-type safety catch, active site C to A 
       mutant sequence

<400>  26

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Ala Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  27
<211>  303
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(303)
<223>  Procaspase-7 DDD wild-type safety catch, active site C to A 
       mutant sequence

<400>  27

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Ala Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Asp Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


