SEQUENCE LISTING

<110> SPIES, THOMAS
      GROH-SPIES, VERONIKA

<120> NEGATIVE IMMUNOMODULATION OF IMMUNE RESPONSES BY ERp5

<130> FHCC:028WO

<140> UNKNOWN
<141> 2008-04-23

<150> 60/913,467
<151> 2007-04-23

<160> 20                            

<170> PatentIn Ver. 2.1

<210> 1
<211> 1365
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (40)..(1191)

<400> 1
cactgcttga gccgctgaga gggtggcgac gtcggggcc atg ggg ctg ggc ccg    54    
                                           Met Gly Leu Gly Pro
                                             1               5

gtc ttc ctg ctt ctg gct ggc atc ttc cct ttt gca cct ccg gga gct   102   
Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe Ala Pro Pro Gly Ala
                 10                  15                  20    

gct gct gag ccc cac agt ctt cgt tat aac ctc acg gtg ctg tcc tgg   150   
Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu Thr Val Leu Ser Trp
             25                  30                  35        

gat gga tct gtg cag tca ggg ttt ctc act gag gta cat ctg gat ggt   198   
Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu Val His Leu Asp Gly
         40                  45                  50            

cag ccc ttc ctg cgc tgt gac agg cag aaa tgc agg gca aag ccc cag   246   
Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys Arg Ala Lys Pro Gln
     55                  60                  65                

gga cag tgg gca gaa gat gtc ctg gga aat aag aca tgg gac aga gag   294   
Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys Thr Trp Asp Arg Glu
 70                  75                  80                  85

acc aga gac ttg aca ggg aac gga aag gac ctc agg atg acc ctg gct   342   
Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu Arg Met Thr Leu Ala
                 90                  95                 100    

cat atc aag gac cag aaa gaa ggc ttg cat tcc ctc cag gag att agg   390   
His Ile Lys Asp Gln Lys Glu Gly Leu His Ser Leu Gln Glu Ile Arg
            105                 110                 115        

gtc tgt gag atc cat gaa gac aac agc acc agg agc tcc cag cat ttc   438   
Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg Ser Ser Gln His Phe
        120                 125                 130            

tac tac gat ggg gag ctc ttc ctc tcc caa aac ctg gag act aag gaa   486   
Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn Leu Glu Thr Lys Glu
    135                 140                 145                

tgg aca atg ccc cag tcc tcc aga gct cag acc ttg gcc atg aac gtc   534   
Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr Leu Ala Met Asn Val
150                 155                 160                 165

agg aat ttc ttg aag gaa gat gcc atg aag acc aag aca cac tat cac   582   
Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr Lys Thr His Tyr His
                170                 175                 180    

gct atg cat gca gac tgc ctg cag gaa cta cgg cga tat cta aaa tcc   630   
Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg Arg Tyr Leu Lys Ser
            185                 190                 195        

ggc gta gtc ctg agg aga aca gtg ccc ccc atg gtg aat gtc acc cgc   678   
Gly Val Val Leu Arg Arg Thr Val Pro Pro Met Val Asn Val Thr Arg
        200                 205                 210            

agc gag gcc tca gag ggc aac att acc gtg aca tgc agg gct tct ggc   726   
Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr Cys Arg Ala Ser Gly
    215                 220                 225                

ttc tat ccc tgg aat atc aca ctg agc tgg cgt cag gat ggg gta tct   774   
Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg Gln Asp Gly Val Ser
230                 235                 240                 245

ttg agc cac gac acc cag cag tgg ggg gat gtc ctg cct gat ggg aat   822   
Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val Leu Pro Asp Gly Asn
                250                 255                 260    

gga acc tac cag acc tgg gtg gcc acc agg att tgc caa gga gag gag   870   
Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile Cys Gln Gly Glu Glu
            265                 270                 275        

cag agg ttc acc tgc tac atg gaa cac agc ggg aat cac agc act cac   918   
Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly Asn His Ser Thr His
        280                 285                 290            

cct gtg ccc tct ggg aaa gtg ctg gtg ctt cag agt cat tgg cag aca   966   
Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln Ser His Trp Gln Thr
    295                 300                 305                

ttc cat gtt tct gct gtt gct gct gct gct att ttt gtt att att att   1014  
Phe His Val Ser Ala Val Ala Ala Ala Ala Ile Phe Val Ile Ile Ile
310                 315                 320                 325

ttc tat gtc cgt tgt tgt aag aag aaa aca tca gct gca gag ggt cca   1062  
Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser Ala Ala Glu Gly Pro
                330                 335                 340    

gag ctc gtg agc ctg cag gtc ctg gat caa cac cca gtt ggg acg agt   1110  
Glu Leu Val Ser Leu Gln Val Leu Asp Gln His Pro Val Gly Thr Ser
            345                 350                 355        

gac cac agg gat gcc aca cag ctc gga ttt cag cct ctg atg tca gat   1158  
Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln Pro Leu Met Ser Asp
        360                 365                 370            

ctt ggg tcc act ggc tcc act gag ggc gcc tag actctacagc caggcagctg 1211  
Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala                          
    375                 380                                      

ggattcaatt ccctgcctgg atctcacgag cactttccct cttggtgcct cagtttcctg 1271  

acctatgaaa cagagaaaat aaaagcactt atttattgtt gttggaggct gcaaaatgtt 1331  

agtagatatg aggcgtttgc agctgtacca tatt                             1365  


<210> 2
<211> 383        
<212> PRT
<213> Homo sapiens

<400> 2
Met Gly Leu Gly Pro Val Phe Leu Leu Leu Ala Gly Ile Phe Pro Phe  
  1               5                  10                  15      
Ala Pro Pro Gly Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu  
             20                  25                  30          
Thr Val Leu Ser Trp Asp Gly Ser Val Gln Ser Gly Phe Leu Thr Glu  
         35                  40                  45              
Val His Leu Asp Gly Gln Pro Phe Leu Arg Cys Asp Arg Gln Lys Cys  
     50                  55                  60                  
Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Asn Lys  
 65                  70                  75                  80  
Thr Trp Asp Arg Glu Thr Arg Asp Leu Thr Gly Asn Gly Lys Asp Leu  
                 85                  90                  95      
Arg Met Thr Leu Ala His Ile Lys Asp Gln Lys Glu Gly Leu His Ser  
            100                 105                 110          
Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Asn Ser Thr Arg  
        115                 120                 125              
Ser Ser Gln His Phe Tyr Tyr Asp Gly Glu Leu Phe Leu Ser Gln Asn  
    130                 135                 140                  
Leu Glu Thr Lys Glu Trp Thr Met Pro Gln Ser Ser Arg Ala Gln Thr  
145                 150                 155                 160  
Leu Ala Met Asn Val Arg Asn Phe Leu Lys Glu Asp Ala Met Lys Thr  
                165                 170                 175      
Lys Thr His Tyr His Ala Met His Ala Asp Cys Leu Gln Glu Leu Arg  
            180                 185                 190          
Arg Tyr Leu Lys Ser Gly Val Val Leu Arg Arg Thr Val Pro Pro Met  
        195                 200                 205              
Val Asn Val Thr Arg Ser Glu Ala Ser Glu Gly Asn Ile Thr Val Thr  
    210                 215                 220                  
Cys Arg Ala Ser Gly Phe Tyr Pro Trp Asn Ile Thr Leu Ser Trp Arg  
225                 230                 235                 240  
Gln Asp Gly Val Ser Leu Ser His Asp Thr Gln Gln Trp Gly Asp Val  
                245                 250                 255      
Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile  
            260                 265                 270          
Cys Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly  
        275                 280                 285              
Asn His Ser Thr His Pro Val Pro Ser Gly Lys Val Leu Val Leu Gln  
    290                 295                 300                  
Ser His Trp Gln Thr Phe His Val Ser Ala Val Ala Ala Ala Ala Ile  
305                 310                 315                 320  
Phe Val Ile Ile Ile Phe Tyr Val Arg Cys Cys Lys Lys Lys Thr Ser  
                325                 330                 335      
Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His  
            340                 345                 350          
Pro Val Gly Thr Ser Asp His Arg Asp Ala Thr Gln Leu Gly Phe Gln  
        355                 360                 365              
Pro Leu Met Ser Asp Leu Gly Ser Thr Gly Ser Thr Glu Gly Ala      
    370                 375                 380                  



<210> 3
<211> 2385
<212> DNA
<213> Homo sapiens

<220> 
<221> CDS
<222> (6)..(1157)

<400> 3
gggcc atg ggg ctg ggc cgg gtc ctg ctg ttt ctg gcc gtc gcc ttc cct 50    
      Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro
        1               5                  10                  15

ttt gca ccc ccg gca gcc gcc gct gag ccc cac agt ctt cgt tac aac   98    
Phe Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn
                 20                  25                  30    

ctc atg gtg ctg tcc cag gat gga tct gtg cag tca ggg ttt ctc gct   146   
Leu Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala
             35                  40                  45        

gag gga cat ctg gat ggt cag ccc ttc ctg cgc tat gac agg cag aaa   194   
Glu Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys
         50                  55                  60            

cgc agg gca aag ccc cag gga cag tgg gca gaa gat gtc ctg gga gct   242   
Arg Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Ala
     65                  70                  75                

gag acc tgg gac aca gag acc gag gac ttg aca gag aat ggg caa gac   290   
Glu Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp
 80                  85                  90                  95

ctc agg agg acc ctg act cat atc aag gac cag aaa gga ggc ttg cat   338   
Leu Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His
                100                 105                 110    

tcc ctc cag gag att agg gtc tgt gag atc cat gaa gac agc agc acc   386   
Ser Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr
            115                 120                 125        

agg ggc tcc cgg cat ttc tac tac aat ggg gag ctc ttc ctc tcc caa   434   
Arg Gly Ser Arg His Phe Tyr Tyr Asn Gly Glu Leu Phe Leu Ser Gln
        130                 135                 140            

aac ctg gag act caa gaa tcg aca gtg ccc cag tcc tcc aga gct cag   482   
Asn Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln
    145                 150                 155                

acc ttg gct atg aac gtc aca aat ttc tgg aag gaa gat gcc atg aag   530   
Thr Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys
160                 165                 170                 175

acc aag aca cac tat cgc gct atg cag gca gac tgc ctg cag aaa cta   578   
Thr Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu
                180                 185                 190    

cag cga tat ctg aaa tcc ggg gtg gcc atc agg aga aca gtg ccc ccc   626   
Gln Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro
            195                 200                 205        

atg gtg aat gtc acc tgc agc gag gtc tca gag ggc aac atc acc gtg   674   
Met Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val
        210                 215                 220            

aca tgc agg gct tcc agc ttc tat ccc cgg aat atc aca ctg acc tgg   722   
Thr Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp
    225                 230                 235                

cgt cag gat ggg gta tct ttg agc cac aac acc cag cag tgg ggg gat   770   
Arg Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp
240                 245                 250                 255

gtc ctg cct gat ggg aat gga acc tac cag acc tgg gtg gcc acc agg   818   
Val Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg
                260                 265                 270    

att cgc caa gga gag gag cag agg ttc acc tgc tac atg gaa cac agc   866   
Ile Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser
            275                 280                 285        

ggg aat cac ggc act cac cct gtg ccc tct ggg aag gcg ctg gtg ctt   914   
Gly Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu
        290                 295                 300            

cag agt caa cgg aca gac ttt cca tat gtt tct gct gct atg cca tgt   962   
Gln Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys
    305                 310                 315                

ttt gtt att att att att ctc tgt gtc cct tgt tgc aag aag aaa aca   1010  
Phe Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr
320                 325                 330                 335

tca gcg gca gag ggt cca gag ctt gtg agc ctg cag gtc ctg gat caa   1058  
Ser Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln
                340                 345                 350    

cac cca gtt ggg aca gga gac cac agg gat gca gca cag ctg gga ttt   1106  
His Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe
            355                 360                 365        

cag cct ctg atg tca gct act ggg tcc act ggt tcc act gag ggc gcc   1154  
Gln Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala
        370                 375                 380            

tag actctacagc caggcggcca ggattcaact ccctgcctgg atctcaccag        1207  
                                                          

cactttccct ctgtttcctg acctatgaaa cagaaaataa catcacttat ttattgttgt 1267  

tggatgctgc aaagtgttag taggtatgag gtgtttgctg ctctgccacg tagagagcca 1327  

gcaaagggat catgaccaac tcaacattcc attggaggct atatgatcaa acagcaaatt 1387  

gtttatcatg aatgcaggat gtgggcaaac tcacgactgc tcctgccaac agaaggtttg 1447  

ctgagggcat tcactccatg gtgctcattg gagttatcta ctgggtcatc tagagcctat 1507  

tgtttgagga atgcagtctt acaagcctac tctggaccca gcagctgact ccttcttcca 1567  

cccctcttct tgctatctcc tataccaata aatacgaagg gctgtggaag atcagagccc 1627  

ttgttcacga gaagcaagaa gccccctgac cccttgttcc aaatatactc ttttgtcttt 1687  

ctctttattc ccacgttcgc cctttgttca gtccaataca gggttgtggg gcccttaaca 1747  

gtgccatatt aattggtatc attatttctg ttgtttttgt ttttgttttt gtttttgttt 1807  

ttgagacaga gtctcactct gtcacccagg ctgcagttca ctggtgtgat ctcagctcac 1867  

tgcaacctct gcctcccagg ttcaagcact tctcgtacct cagactcccg aatagctggg 1927  

attacagaca ggcaccacca cacccagcta atttttgtat tttttgtaga gacggggttt 1987  

cgccaagttg accagcccag tttcaaactc ctgacctcag gtgatctgcc tgccttggca 2047  

tcccaaagtg ctgggattac aagaatgagc caccgtgcct ggcctatttt attatattgt 2107  

aatatatttt attatattag ccaccatgcc tgtcctattt tcttatgttt taatatattt 2167  

taatatatta catgtgcagt aattagatta tcatgggtga actttatgag tgagtatctt 2227  

ggtgatgact cctcctgacc agcccaggac cagctttctt gtcaccttga ggtcccctcg 2287  

ccccgtcaca ccgttatgca ttactctgtg tctactatta tgtgtgcata atttataccg 2347  

taaatgttta ctctttaaat agaaaaaaaa aaaaaaaa                         2385  


<210> 4
<211> 383        
<212> PRT
<213> Homo sapiens

<400> 4
Met Gly Leu Gly Arg Val Leu Leu Phe Leu Ala Val Ala Phe Pro Phe  
  1               5                  10                  15      
Ala Pro Pro Ala Ala Ala Ala Glu Pro His Ser Leu Arg Tyr Asn Leu  
             20                  25                  30          
Met Val Leu Ser Gln Asp Gly Ser Val Gln Ser Gly Phe Leu Ala Glu  
         35                  40                  45              
Gly His Leu Asp Gly Gln Pro Phe Leu Arg Tyr Asp Arg Gln Lys Arg  
     50                  55                  60                  
Arg Ala Lys Pro Gln Gly Gln Trp Ala Glu Asp Val Leu Gly Ala Glu  
 65                  70                  75                  80  
Thr Trp Asp Thr Glu Thr Glu Asp Leu Thr Glu Asn Gly Gln Asp Leu  
                 85                  90                  95      
Arg Arg Thr Leu Thr His Ile Lys Asp Gln Lys Gly Gly Leu His Ser  
            100                 105                 110          
Leu Gln Glu Ile Arg Val Cys Glu Ile His Glu Asp Ser Ser Thr Arg  
        115                 120                 125              
Gly Ser Arg His Phe Tyr Tyr Asn Gly Glu Leu Phe Leu Ser Gln Asn  
    130                 135                 140                  
Leu Glu Thr Gln Glu Ser Thr Val Pro Gln Ser Ser Arg Ala Gln Thr  
145                 150                 155                 160  
Leu Ala Met Asn Val Thr Asn Phe Trp Lys Glu Asp Ala Met Lys Thr  
                165                 170                 175      
Lys Thr His Tyr Arg Ala Met Gln Ala Asp Cys Leu Gln Lys Leu Gln  
            180                 185                 190          
Arg Tyr Leu Lys Ser Gly Val Ala Ile Arg Arg Thr Val Pro Pro Met  
        195                 200                 205              
Val Asn Val Thr Cys Ser Glu Val Ser Glu Gly Asn Ile Thr Val Thr  
    210                 215                 220                  
Cys Arg Ala Ser Ser Phe Tyr Pro Arg Asn Ile Thr Leu Thr Trp Arg  
225                 230                 235                 240  
Gln Asp Gly Val Ser Leu Ser His Asn Thr Gln Gln Trp Gly Asp Val  
                245                 250                 255      
Leu Pro Asp Gly Asn Gly Thr Tyr Gln Thr Trp Val Ala Thr Arg Ile  
            260                 265                 270          
Arg Gln Gly Glu Glu Gln Arg Phe Thr Cys Tyr Met Glu His Ser Gly  
        275                 280                 285              
Asn His Gly Thr His Pro Val Pro Ser Gly Lys Ala Leu Val Leu Gln  
    290                 295                 300                  
Ser Gln Arg Thr Asp Phe Pro Tyr Val Ser Ala Ala Met Pro Cys Phe  
305                 310                 315                 320  
Val Ile Ile Ile Ile Leu Cys Val Pro Cys Cys Lys Lys Lys Thr Ser  
                325                 330                 335      
Ala Ala Glu Gly Pro Glu Leu Val Ser Leu Gln Val Leu Asp Gln His  
            340                 345                 350          
Pro Val Gly Thr Gly Asp His Arg Asp Ala Ala Gln Leu Gly Phe Gln  
        355                 360                 365              
Pro Leu Met Ser Ala Thr Gly Ser Thr Gly Ser Thr Glu Gly Ala      
    370                 375                 380                  



<210> 5
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 5
gatcttgttg tcaaagttgg tgcagttgtc ttcttctcaa ctgcaccaac tttgacaaca 60    
tttttg                                                            66    


<210> 6
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 6
aattcaaaaa tgttgtcaaa gttggtgcag ttgagaagaa gacaactgca ccaactttga 60    
caacaa                                                            66    


<210> 7
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 7
gatcttgata gttcaagtaa gaaggatgtc ttcttctcat ccttcttact tgaactatca 60    
tttttg                                                            66    


<210> 8
<211> 66
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 8
aattcaaaaa tgatagttca agtaagaagg atgagaagaa gacatccttc ttacttgaac 60    
tatcaa                                                            66    


<210> 9
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 9
tgcggcacgc tgcagggct                                              19    


<210> 10
<211> 27
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 10
ttgacagtga ccacaccatg gagcata                                     27    


<210> 11
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 11
ggaacggaaa ggacctcagg atg                                         23    


<210> 12
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 12
ctgggagctc ctggtgctgt tg                                          22   

<210> 13
<211> 1790
<212> DNA
<213> Homo sapiens

<400> 13
ggcgcggggg cgcggcgtgc ggcacgctgc agggctgaag cggcggcggc ggtggggact 60    
gcacgtagcc cggcgctcgg catggctctc ctggtgctcg gtctggtgag ctgtaccttc 120   
tttctggcag tgaatggtct gtattcctct agtgatgatg tgatcgaatt aactccatcg 180   
aatttcaacc gagaagttat tcagagtgat agtttgtggc ttgtagaatt ctatgctcca 240   
tggtgtggtc actgtcaaag attaacacca gaatggaaga aagcagcaac tgcattaaaa 300   
gatgttgtca aagttggtgc agttgatgca gataagcatc attccctagg aggtcagtat 360   
ggtgttcagg gatttcctac cattaagatt tttggatcca acaaaaacag accagaagat 420   
taccaaggtg gcagaactgg tgaagccatt gtagatgctg cgctgagtgc tctgcgccag 480   
ctcgtgaagg atcgcctcgg gggacggagc ggaggataca gttctggaaa acaaggcaga 540   
agtgatagtt caagtaagaa ggatgtgatt gagctgacag acgacagctt tgataagaat 600   
gttctggaca gtgaagatgt ttggatggtt gagttctatg ctccttggtg tggacactgc 660   
aaaaacctag agccagagtg ggctgccgca gcttcagaag taaaagagca gacgaaagga 720   
aaagtgaaac tggcagctgt ggatgctaca gtcaatcagg ttctggcctc ccgatacggg 780   
attagaggat ttcctacaat caagatattt cagaaaggcg agtctcctgt ggattatgac 840   
ggtgggcgga caagatccga catcgtgtcc cgggcccttg atttgttttc tgataacgcc 900   
ccacctcctg agctgcttga gattatcaac gaggacattg ccaagaggac gtgtgaggag 960   
caccagctct gtgttgtggc tgtgctgccc catatccttg atactggagc tgcaggcaga 1020  
aattcttatc tggaagttct tctgaagttg gcagacaaat acaaaaagaa aatgtggggg 1080  
tggctgtgga cagaagctgg agcccagtct gaacttgaga ccgcgttggg gattggaggg 1140  
tttgggtacc ccgccatggc cgccatcaat gcacgcaaga tgaaatttgc tctgctaaaa 1200  
ggctccttca gtgagcaagg catcaacgag tttctcaggg agctctcttt tgggcgtggc 1260  
tccacggcac ctgtaggagg cggggctttc cctaccatcg ttgagagaga gccttgggac 1320  
ggcagggatg gcgagcttcc cgtggaggat gacattgacc tcagtgatgt ggagcttgat 1380  
gacttaggga aagatgagtt gtgagagcca caacagaggc ttcagaccat tttcttttct 1440  
tgggagccag tggatttttc cagcagtgaa gggacattct ctacactcag atgactctac 1500  
cagtggcctt ttaaccaaga agtagtactt gattggtcat ttgaaaacac tgcaacagtg 1560  
aacttttgca tctcaagaaa acattgaaaa attctatgaa ttgttgtagc cggtgaattg 1620  
agtcgtattc tgtcacataa tattttgaag aaaacttggc tgtcgaaaca tttttctctc 1680  
tgactgctgc ttgaatgttc ttggaggctg tttcttatgt atgggttttt tttaatgtga 1740  
tcccttcatt tgaatattaa tggctttttc cattaaagaa taaaatattt            1790  


<210> 14
<211> 440
<212> PRT
<213> Homo sapiens

<400> 14
Met Ala Leu Leu Val Leu Gly Leu Val Ser Cys Thr Phe Phe Leu Ala  
  1               5                  10                  15    

Val Asn Gly Leu Tyr Ser Ser Ser Asp Asp Val Ile Glu Leu Thr Pro  
             20                  25                  30        

Ser Asn Phe Asn Arg Glu Val Ile Gln Ser Asp Ser Leu Trp Leu Val  
         35                  40                  45            

Glu Phe Tyr Ala Pro Trp Cys Gly His Cys Gln Arg Leu Thr Pro Glu  
     50                  55                  60                

Trp Lys Lys Ala Ala Thr Ala Leu Lys Asp Val Val Lys Val Gly Ala  
 65                  70                  75                  80

Val Asp Ala Asp Lys His His Ser Leu Gly Gly Gln Tyr Gly Val Gln  
                 85                  90                  95    

Gly Phe Pro Thr Ile Lys Ile Phe Gly Ser Asn Lys Asn Arg Pro Glu  
            100                 105                 110        

Asp Tyr Gln Gly Gly Arg Thr Gly Glu Ala Ile Val Asp Ala Ala Leu  
        115                 120                 125            

Ser Ala Leu Arg Gln Leu Val Lys Asp Arg Leu Gly Gly Arg Ser Gly  
    130                 135                 140                

Gly Tyr Ser Ser Gly Lys Gln Gly Arg Ser Asp Ser Ser Ser Lys Lys  
145                 150                 155                 160

Asp Val Ile Glu Leu Thr Asp Asp Ser Phe Asp Lys Asn Val Leu Asp  
                165                 170                 175    

Ser Glu Asp Val Trp Met Val Glu Phe Tyr Ala Pro Trp Cys Gly His  
            180                 185                 190        

Cys Lys Asn Leu Glu Pro Glu Trp Ala Ala Ala Ala Ser Glu Val Lys  
        195                 200                 205            

Glu Gln Thr Lys Gly Lys Val Lys Leu Ala Ala Val Asp Ala Thr Val  
    210                 215                 220                

Asn Gln Val Leu Ala Ser Arg Tyr Gly Ile Arg Gly Phe Pro Thr Ile  
225                 230                 235                 240

Lys Ile Phe Gln Lys Gly Glu Ser Pro Val Asp Tyr Asp Gly Gly Arg  
                245                 250                 255    

Thr Arg Ser Asp Ile Val Ser Arg Ala Leu Asp Leu Phe Ser Asp Asn  
            260                 265                 270        

Ala Pro Pro Pro Glu Leu Leu Glu Ile Ile Asn Glu Asp Ile Ala Lys  
        275                 280                 285            

Arg Thr Cys Glu Glu His Gln Leu Cys Val Val Ala Val Leu Pro His  
    290                 295                 300                

Ile Leu Asp Thr Gly Ala Ala Gly Arg Asn Ser Tyr Leu Glu Val Leu  
305                 310                 315                 320

Leu Lys Leu Ala Asp Lys Tyr Lys Lys Lys Met Trp Gly Trp Leu Trp  
                325                 330                 335    

Thr Glu Ala Gly Ala Gln Ser Glu Leu Glu Thr Ala Leu Gly Ile Gly  
            340                 345                 350        

Gly Phe Gly Tyr Pro Ala Met Ala Ala Ile Asn Ala Arg Lys Met Lys  
        355                 360                 365            

Phe Ala Leu Leu Lys Gly Ser Phe Ser Glu Gln Gly Ile Asn Glu Phe  
    370                 375                 380                

Leu Arg Glu Leu Ser Phe Gly Arg Gly Ser Thr Ala Pro Val Gly Gly  
385                 390                 395                 400

Gly Ala Phe Pro Thr Ile Val Glu Arg Glu Pro Trp Asp Gly Arg Asp  
                405                 410                 415    

Gly Glu Leu Pro Val Glu Asp Asp Ile Asp Leu Ser Asp Val Glu Leu  
            420                 425                 430        

Asp Asp Leu Gly Lys Asp Glu Leu                                  
        435                 440


<210> 15
<211> 405
<212> DNA
<213> Homo sapiens

<400> 15
atggctgtct tggggctgct cttctgcctg gtgacattcc caagctgtgt tctatcccag 60    
gtgcacctga agcagtcagg acctggccta gtgcagccct cacagagcct gtccatcacc 120   
tgcacagtct ctggtttctc attaactaac tatggtgtcc actgggttcg ccagtctcca 180   
ggaaagggtc tggagtggct gggagtgata tggagtggtg gattcactga ctctactgca 240   
gctttcatat ccagactgag catcagcaag gacaattcca agagccaagt tttctttaaa 300   
atgaacagtc tgcaaactga tgacacagcc atatattact gtgccagaaa gggcgggtat 360   
gctatggact actggggtca aggaacctca gtcaccgtct cctca                 405   


<210> 16
<211> 135
<212> PRT
<213> Homo sapiens

<400> 16
Met Ala Val Leu Gly Leu Leu Phe Cys Leu Val Thr Phe Pro Ser Cys  
  1               5                  10                  15    

Val Leu Ser Gln Val His Leu Lys Gln Ser Gly Pro Gly Leu Val Gln  
             20                  25                  30        

Pro Ser Gln Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu  
         35                  40                  45            

Thr Asn Tyr Gly Val His Trp Val Arg Gln Ser Pro Gly Lys Gly Leu  
     50                  55                  60                

Glu Trp Leu Gly Val Ile Trp Ser Gly Gly Phe Thr Asp Ser Thr Ala  
 65                  70                  75                  80

Ala Phe Ile Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln  
                 85                  90                  95    

Val Phe Phe Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Ile Tyr  
            100                 105                 110        

Tyr Cys Ala Arg Lys Gly Gly Tyr Ala Met Asp Tyr Trp Gly Gln Gly  
        115                 120                 125            

Thr Ser Val Thr Val Ser Ser                                      
    130                 135


<210> 17
<211> 393
<212> DNA
<213> Homo sapiens

<400> 17
atggattttc aggtgcagat tttcagcttc ctgctaatca gtgcctcagt cttaatgtcc 60    
agaggacaaa ttgttctcac ccagtctcca gcaatcatgt ctgcatctct aggggaacgg 120   
gtcaccatga cctgcactgc cagctcaagt gtaagttcca gttacttgca ctggtaccag 180   
cagaagccag gatcctcccc caaactctgg atttttagca catccaacct ggcttctgga 240   
gtcccagctc gcttcagtgg cagtgggtct gggacctctt actctctcac aatcagcagc 300   
atggaggctg aagatgctgc cacttattac tgccaccagt atcatcgttc cccattcacg 360   
ttcggctcgg ggacaaagtt ggaaataaaa cgg                              393   


<210> 18
<211> 131
<212> PRT
<213> Homo sapiens

<400> 18
Met Asp Phe Gln Val Gln Ile Phe Ser Phe Leu Leu Ile Ser Ala Ser  
  1               5                  10                  15    

Val Leu Met Ser Arg Gly Gln Ile Val Leu Thr Gln Ser Pro Ala Ile  
             20                  25                  30        

Met Ser Ala Ser Leu Gly Glu Arg Val Thr Met Thr Cys Thr Ala Ser  
         35                  40                  45            

Ser Ser Val Ser Ser Ser Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly  
     50                  55                  60                

Ser Ser Pro Lys Leu Trp Ile Phe Ser Thr Ser Asn Leu Ala Ser Gly  
 65                  70                  75                  80

Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu  
                 85                  90                  95    

Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His  
            100                 105                 110        

Gln Tyr His Arg Ser Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu  
        115                 120                 125            

Ile Lys Arg                                                      
    130    


<210> 19
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 19
gatcttatgt caagttgtat agttattcaa gagataacta tacaacttga catatttttg 60    


<210> 20
<211> 60
<212> DNA
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Primer

<400> 20
aattcaaaaa tatgtcaagt tgtatagtta tctcttgaat aactatacaa cttgacataa 60    


