
                                SEQUENCE LISTING

<110> Dietrich, Stephan A.
      Reiman, Eric .
      Webster, Jennifer
      Christopher, Heward B.

<120> METHODS OF DIAGNOSING ALZHEIMER'S
  DISEASE AND ASSOCIATED MARKERS
  

<130> 62755-20002.00

<140> Not Yet Assigned    
<141> Concurrently Herewith            

<150> 60/933,582          
<151> 2007-06-06  

<150> 60/925,638         
<151> 2007-04-20 

<160> 5

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Haplotype

<221> misc_feature   
<222> 3, 7
<223> n = A,T,C or G

<400> 1
tcngcantga ggtgtctt                                               18

<210> 2
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Haplotype

<221> misc_feature   
<222> 3, 7
<223> n = A,T,C or G

<400> 2
ctnaagncag atcagacg                                               18

<210> 3
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Haplotype

<221> misc_feature   
<222> 3, 7
<223> n = A,T,C or G

<400> 3
ctnaagncag agcagccg                                               18

<210> 4
<211> 6006
<212> DNA
<213> Homo sapiens

<400> 4
atgagcggcg gcggcgacgt ggtgtgcacc ggctggctga ggaaatcgcc tcccgagaag 60
aagttgaggc gctatgcctg gaagaaacgc tggtttatcc tgcggagtgg ccggatgagc 120
ggtgacccag atgttctgga atactacaag aacgatcact ccaagaagcc tctgcggatc 180
atcaacctga acttctgtga gcaggtagat gcaggcctga cctttaacaa gaaggagctg 240
caggatagtt ttgtgtttga catcaagacc agtgaacgca ccttttacct ggtggctgag 300
acagaagagg acatgaataa gtgggtccag agcatctgcc agatctgtgg cttcaatcag 360
gctgaggaga gcacagactc cctgagaaat gtttcctcag ccggtcatgg cccccgctct 420
tctccagctg agctcagcag ctctagccag caccttctcc gagagcgcaa gtcctcagcc 480
ccatcacact ccagccagcc aactctgttc acgtttgaac cccctgtgtc aaaccacatg 540
cagcccacct tgtccaccag cgcacctcag gagtatctct acttgcacca gtgcataagc 600
cgaagagcag aaaatgcaag gagtgccagc ttctctcagg gcaccagagc ctcttttctc 660
atgaggagtg acacagctgt acaaaaactt gcccagggca atggacactg tgtcaacggg 720
atcagtggtc aagtccatgg cttctatagc cttcccaagc cgagccggca caatacagaa 780
ttcagagaca gtacctacga cctcccccgc agcctggcct cccatggcca caccaagggc 840
agcctcacag gctccgagac agataatgag gatgtgtaca ccttcaagac gcccagcaac 900
accctgtgca gggagttcgg ggacctcctg gtagacaata tggatgttcc ggccacccca 960
ctctcagcct accagatccc taggacattc actctggaca aaaaccacaa tgccatgaca 1020
gtggccactc ctggggactc agccatagct cccccacccc gcccccccaa gccaagtcag 1080
gcagaaacac ctcgatgggg cagtcctcag cagagaccgc caatcagtga aaatagcaga 1140
tctgtcgctg ccaccatccc cagacgcaac accctccctg caatggacaa cagccgactt 1200
caccgagctt cttcctgtga gacctacgag tacccacagc gtggtggaga gagtgcaggc 1260
cggtctgctg aatccatgag tgatggagtt ggctctttcc tgccagggaa aatgattgtg 1320
ggccgatcgg acagcaccaa ttctgaagac aactatgtgc ccatgaatcc aggttcttcc 1380
accctgttgg ccatggaacg agcaggtgat aattcccaga gcgtctacat cccaatgagc 1440
ccaggggccc atcactttga ctcacttggc tacccatcaa caacccttcc tgtgcaccga 1500
ggccccagca gaggaagtga gattcagcca ccccctgtca accgcaacct caaacctgat 1560
cggaaagcaa agccaacacc acttgacctg aggaacaaca ccgtcatcga tgaactcccc 1620
ttcaagtcac ctatcaccaa gtcttggtct agggccaacc acaccttcaa ctccagctcc 1680
tcccagtact gccgccccat ctccacccag agcatcacca gcacagactc aggagacagc 1740
gaagagaact atgtccctat gcaaaaccca gtgtctgcat ctcccgttcc cagtggcacg 1800
aacagtcctg cccctaagaa gagcaccggc agcgttgatt atctggccct ggacttccag 1860
ccgagctccc caagccccca ccgcaagcca tctacttcat ccgtcacctc tgatgagaag 1920
gtggactacg ttcaggtgga caaggagaag acccaggccc tgcagaacac catgcaggag 1980
tggacagacg tgcggcagtc ctcagagcct tccaagggtg ccaagctgtg atgagagggc 2040
caccgcagag cccaggaggc agcatctcca gagctggccc ttcccatctc ccctctcccc 2100
tctcccgttc ttcctcccat ccacctcctc tctactctgc cagtctcagc cttcaaagca 2160
cttgacatca gggaccctga acccttcccc tgggaggtga gggcctgatc aaggcacctc 2220
ctctgcccac tcggggccca gctgtgattt ttatcagtaa tggccatgcc tccacccacc 2280
ttagttagga gctacttcca aaaagcatcc ttcagcctct tcctgtcctt tagacctgac 2340
tctctaccag atgtttggag ggaagggctg gggctctgag ccagattcca cacctcacgt 2400
tcagtcacag ccctcagcta tcttccctcc ggccactggg ctacctctcc ttcagtccca 2460
gaagacaagt ctcaccaacc cagggagtca aggaccagca aaccaaagtg gataatggac 2520
tttttcattc ctgtttttct tggcaggaga gaagcaaggc cactaaaaga ggagatggtg 2580
gagacggagg ctcagcagtg gtcttgaggg gtaaaggact tagatgccca gatgaagagg 2640
gaaagctgac atctgcaggg aacccacttt gaggctgagg ccatggcagg acagctgctg 2700
tggggtgcag aggcagaaga tgaaggacaa aaggaaggga aaactgatgg ccaacctaga 2760
gcagcaagga gcagggcttg gagctcgggt ggtggagatg acaaggacac tgtggggtct 2820
gggtccccag aactctggag ctacaggcca ctctaggccc aagggctagt cctcttcccc 2880
agtcccctca gaggcccccg ccagccccac cttgaaagca gcatacaggg gaaggcttgg 2940
accaagctgg gcgaccaagc acatggggca ggaacacatg gtaaaggggt ggggaatatg 3000
ggagggagtg tggtgtggat gggggtgatg cagggactga ggggaaccct gggacaggca 3060
caggctgggc agaggcacag ggcagtgcag gggactctgc agtggggtcg ggaagtgagt 3120
ttctttgcag tgagcagtgc agtggaagtc gggcacagag gtagcagaca gatgtgaagc 3180
agtggtgaag gccatgtagc aagtggggaa atacatccaa agggcctggg agttgggggg 3240
tgcccaacgc aatccttggg ggtgcagggt ggagcagaaa gtgaaggagg gacacgtgca 3300
agagtggtgt gcatggtggt gtgacatgag gaccgttcct aggatgggac agtgggtcag 3360
gcaggacaag gagaaagcag ggcagaatga tgcctagagg accacatcag gcatggctga 3420
cagcttgtgc ccatgggctg tggcgtatgt cagatcgcag ggtaggaacg agtctggcct 3480
ggtgccggcc cagtgtttcc tcagctcatc cgccctctgt tgctccctag cattccagga 3540
gccatcttgg actctcctcc ccaggtttga aaggccatca gattagcagg gacggggtgt 3600
agggcatcac ccaaggttcc ttctcttaaa ctaagggtgg gggatctgaa tgtttttatg 3660
ttgactgttc ttgactaaat tttcaagagt ttcagaagca acaggacaga ccagacgttt 3720
cattctaccc tggggcgaac agaacttctt cctcccaaac aatgacttcc tgccatgttt 3780
gatggggaca gctaccactg tcctctgccc ccattcccct ttcagctccc atgagcatgc 3840
atagttcacc agaccaatgg cctagccatt ctctaagtcc catcctggaa gaagttattt 3900
cttcaagagc tgcacctctc ctcctagcat tagtttagat caactcaagg agtatttatt 3960
aatggctgct gtctccagtt tctggggtta agcactaagg acacaagaat caatcagacc 4020
ttctccctga acttaagata gccacaatca gaaaaaggac aaggacatga gacagtggtg 4080
atggccatca gacagagact tcaaatgctg atggagggca gaggaagtac ttagggaggt 4140
tggtgtcaga ggcaggagtg ggggatcagg gaaggtggat tctaggaaaa gggagtgcct 4200
gaggtaggcc ttagaagggg atgagtcaga tttttacaga ggaggagggc agggcttggg 4260
tccagtggag gaagaaggaa ggagaggctt ggaaagcctt gtgtcttggg aaaaaaaggc 4320
ctttgagcat atgggtccag ccactcagaa gtgcaggggc catgccttgg tgttccaata 4380
agtgaatgga agcagtggtg gtagctacac tgggcagagt tggcagggtg ctggttcact 4440
ctgcccagcc ctgaatgtgt gccttaaagg ccccctacaa ggggccccat acgacagagc 4500
ttttaactgg tgccttccct gtacccgcag cagccacaag tgggcccaga ctattgcagc 4560
ctcccataaa catgtgagca tgttctgagt gtgccatgat gtgagtggac ctggctggaa 4620
tcttcggaga gcgactgagg tgttcaaatc gaatctccca ggaggcttcc ttccagcccc 4680
ctattctggt aactaccagg aggcttcctt ccagccccct attctggtaa ctaccaaaat 4740
ccctcgggtg caagtgtagg ggtagagatg gaaggatgag aggtgaaatt gaccttttga 4800
aagcaaagct ctggctcaca ggccccaaac taccagccgt atctagcata tccccaccct 4860
ccacccacta cctcctccaa caaaggagtc aactcagttg aaaaaactgg tcctttggcc 4920
tatccatggg tcaaagtcca cctctcctgg gggcctggag aggactgagc ctacggaaag 4980
gggatacctt cccactcagc actgcttcac acaggccccc tgcctggggc tctccaagga 5040
gccttcttca cccacttcca gctccacttc tgcaaggtta agtcaagtga gaacgatgag 5100
aaatagggag atggtgtctc cttaagtcct tgatctgcct gtctgtggaa tgggaggttg 5160
gattagctgc gctgaggtcc catccacagc tggtgctcag ctgcttgaag gggagactcc 5220
ctcctctgta acttctttct gggggattgg ggtgggcagt acctatcccc agtcccctcc 5280
tagcttgact ttagtggttt ccaatgtaga agttaacaaa gtatgcccca ttcctgtgac 5340
aaaagcacaa ccattctgaa gttactggag catgggctca gctcatcctc cctctggccc 5400
cttctcccat ggggacatct cggcccagca cccctatccc atttccagag ttcttccttc 5460
cccatctggg ccttcataaa atgcagggga agccagactg gtctcaggag cgctaaagcc 5520
cttccgtggg gggtcgtctt tctgggacta gccctgctgt ttaggacctg ggaccacaat 5580
ggggtacctg ccgagggggt ccccaagaga tccaggctgt catgtgattt atggtggcat 5640
gtgttgtgta tttgttggct acttgtgtct tgaaatctag aattatttca cgcagaattg 5700
tcactgtttg tcaggaagag aaaatgggct agtggaagcc cagtcttgag ttcttgtctt 5760
gttaccattt aaaattgaca tttaattttc aaatcactgt tggtgcctaa tcacttaagt 5820
tattaattta ttctgttgta ttcttttttt taaattgtaa catatttatc cggtgggtgg 5880
gacaggagtg tgttcaagtg ggtcatgttt ttgctgtggt gacacatggt acaggcttgg 5940
agcttgcagg tccctttcta ctgtggtgtt ggagcaggac aataaagtcc actagaaatg 6000
cacccc                                                            6006



<210> 5
<211> 676
<212> PRT
<213> Homo sapiens


<400> 5
Met Ser Gly Gly Gly Asp Val Val Cys Thr Gly Trp Leu Arg Lys Ser
 1               5                  10                  15      
Pro Pro Glu Lys Lys Leu Arg Arg Tyr Ala Trp Lys Lys Arg Trp Phe
            20                  25                  30          
Ile Leu Arg Ser Gly Arg Met Ser Gly Asp Pro Asp Val Leu Glu Tyr
        35                  40                  45              
Tyr Lys Asn Asp His Ser Lys Lys Pro Leu Arg Ile Ile Asn Leu Asn
    50                  55                  60                  
Phe Cys Glu Gln Val Asp Ala Gly Leu Thr Phe Asn Lys Lys Glu Leu
65                  70                  75                  80  
Gln Asp Ser Phe Val Phe Asp Ile Lys Thr Ser Glu Arg Thr Phe Tyr
                85                  90                  95      
Leu Val Ala Glu Thr Glu Glu Asp Met Asn Lys Trp Val Gln Ser Ile
            100                 105                 110         
Cys Gln Ile Cys Gly Phe Asn Gln Ala Glu Glu Ser Thr Asp Ser Leu
        115                 120                 125             
Arg Asn Val Ser Ser Ala Gly His Gly Pro Arg Ser Ser Pro Ala Glu
    130                 135                 140                 
Leu Ser Ser Ser Ser Gln His Leu Leu Arg Glu Arg Lys Ser Ser Ala
145                 150                 155                 160 
Pro Ser His Ser Ser Gln Pro Thr Leu Phe Thr Phe Glu Pro Pro Val
                165                 170                 175     
Ser Asn His Met Gln Pro Thr Leu Ser Thr Ser Ala Pro Gln Glu Tyr
            180                 185                 190         
Leu Tyr Leu His Gln Cys Ile Ser Arg Arg Ala Glu Asn Ala Arg Ser
        195                 200                 205             
Ala Ser Phe Ser Gln Gly Thr Arg Ala Ser Phe Leu Met Arg Ser Asp
    210                 215                 220                 
Thr Ala Val Gln Lys Leu Ala Gln Gly Asn Gly His Cys Val Asn Gly
225                 230                 235                 240 
Ile Ser Gly Gln Val His Gly Phe Tyr Ser Leu Pro Lys Pro Ser Arg
                245                 250                 255     
His Asn Thr Glu Phe Arg Asp Ser Thr Tyr Asp Leu Pro Arg Ser Leu
            260                 265                 270         
Ala Ser His Gly His Thr Lys Gly Ser Leu Thr Gly Ser Glu Thr Asp
        275                 280                 285             
Asn Glu Asp Val Tyr Thr Phe Lys Thr Pro Ser Asn Thr Leu Cys Arg
    290                 295                 300                 
Glu Phe Gly Asp Leu Leu Val Asp Asn Met Asp Val Pro Ala Thr Pro
305                 310                 315                 320 
Leu Ser Ala Tyr Gln Ile Pro Arg Thr Phe Thr Leu Asp Lys Asn His
                325                 330                 335     
Asn Ala Met Thr Val Ala Thr Pro Gly Asp Ser Ala Ile Ala Pro Pro
            340                 345                 350         
Pro Arg Pro Pro Lys Pro Ser Gln Ala Glu Thr Pro Arg Trp Gly Ser
        355                 360                 365             
Pro Gln Gln Arg Pro Pro Ile Ser Glu Asn Ser Arg Ser Val Ala Ala
    370                 375                 380                 
Thr Ile Pro Arg Arg Asn Thr Leu Pro Ala Met Asp Asn Ser Arg Leu
385                 390                 395                 400 
His Arg Ala Ser Ser Cys Glu Thr Tyr Glu Tyr Pro Gln Arg Gly Gly
                405                 410                 415     
Glu Ser Ala Gly Arg Ser Ala Glu Ser Met Ser Asp Gly Val Gly Ser
            420                 425                 430         
Phe Leu Pro Gly Lys Met Ile Val Gly Arg Ser Asp Ser Thr Asn Ser
        435                 440                 445             
Glu Asp Asn Tyr Val Pro Met Asn Pro Gly Ser Ser Thr Leu Leu Ala
    450                 455                 460                 
Met Glu Arg Ala Gly Asp Asn Ser Gln Ser Val Tyr Ile Pro Met Ser
465                 470                 475                 480 
Pro Gly Ala His His Phe Asp Ser Leu Gly Tyr Pro Ser Thr Thr Leu
                485                 490                 495     
Pro Val His Arg Gly Pro Ser Arg Gly Ser Glu Ile Gln Pro Pro Pro
            500                 505                 510         
Val Asn Arg Asn Leu Lys Pro Asp Arg Lys Ala Lys Pro Thr Pro Leu
        515                 520                 525             
Asp Leu Arg Asn Asn Thr Val Ile Asp Glu Leu Pro Phe Lys Ser Pro
    530                 535                 540                 
Ile Thr Lys Ser Trp Ser Arg Ala Asn His Thr Phe Asn Ser Ser Ser
545                 550                 555                 560 
Ser Gln Tyr Cys Arg Pro Ile Ser Thr Gln Ser Ile Thr Ser Thr Asp
                565                 570                 575     
Ser Gly Asp Ser Glu Glu Asn Tyr Val Pro Met Gln Asn Pro Val Ser
            580                 585                 590         
Ala Ser Pro Val Pro Ser Gly Thr Asn Ser Pro Ala Pro Lys Lys Ser
        595                 600                 605             
Thr Gly Ser Val Asp Tyr Leu Ala Leu Asp Phe Gln Pro Ser Ser Pro
    610                 615                 620                 
Ser Pro His Arg Lys Pro Ser Thr Ser Ser Val Thr Ser Asp Glu Lys
625                 630                 635                 640 
Val Asp Tyr Val Gln Val Asp Lys Glu Lys Thr Gln Ala Leu Gln Asn
                645                 650                 655     
Thr Met Gln Glu Trp Thr Asp Val Arg Gln Ser Ser Glu Pro Ser Lys
            660                 665                 670         
Gly Ala Lys Leu
        675    
