SEQUENCE LISTING

<110> STAPLETON, JACK T.
      XIANG, JINHUA
      CHANG, QING
      MCLINDEN, JAMES

<120> FLAVIVIRUS NS5A PROTEINS FOR THE TREATMENT OF HIV

<130> IOWA:100WO

<140> UNKNOWN
<141> 2008-03-20

<150> 60/896,454
<151> 2007-03-22

<150> 60/947,836
<151> 2007-07-03

<160> 9                             

<170> PatentIn Ver. 2.1

<210> 1
<211> 9377
<212> DNA
<213> Hepatitis GB virus C

<220> 
<221> CDS
<222> (534)..(9065)

<400> 1
cccccccccc ggcactgggt gcaagcccca gaaaccgacg cctactgaag tagacgtaat 60    

ggccccgcgc cgaaccggcg accggccaaa aggtggtgga tgggtgatga cagggttggt 120   

aggtcgtaaa tcccggtcat cctggtagcc actataggtg ggtcttaagg ggaggctacg 180   

gtccctcttg cgcatatgga ggaaaagcgc acggtccaca ggtgttggtc ctaccggtgt 240   

aataaggacc cggcgctagg cacgccgtta aaccgagccc gttactcccc tgggcaaacg 300   

acgcccacgt acggtccacg tcgcccttca atgtctctct tgaccaatag gcgtagccgg 360   

cgagttgaca aggaccagtg ggggccgggc gggaggggga aggaccccca ccgctgccct 420   

tcccggggag gcgggaaatg catggggcca cccagctccg cggcggccta cagccggggt 480   

agcccaagaa ccttcgggtg agggcgggtg gcatttcttt tcctataccg atc atg    536   
                                                           Met
                                                             1

gca gtc ctt ctg ctc cta ctc gtg gtg gag gcc ggg gct att tta gcc   584   
Ala Val Leu Leu Leu Leu Leu Val Val Glu Ala Gly Ala Ile Leu Ala
              5                  10                  15        

ccg gcc acc cat gct tgt agc gcg aaa ggg caa tat tts ctc aca aac   632   
Pro Ala Thr His Ala Cys Ser Ala Lys Gly Gln Tyr Xaa Leu Thr Asn
         20                  25                  30            

tgt tgc gcc ctg gag gac ata ggc ttc tgc ctg gag ggc gga tgc ctg   680   
Cys Cys Ala Leu Glu Asp Ile Gly Phe Cys Leu Glu Gly Gly Cys Leu
     35                  40                  45                

gtg gct ctg ggg tgc acc att tgc acc gac cgc tgc tgg cca ctg tat   728   
Val Ala Leu Gly Cys Thr Ile Cys Thr Asp Arg Cys Trp Pro Leu Tyr
 50                  55                  60                  65

cag gcg ggt ttg gcc gtg cgg ccc ggc aag tcc gcc gcc cag ttg gtg   776   
Gln Ala Gly Leu Ala Val Arg Pro Gly Lys Ser Ala Ala Gln Leu Val
                 70                  75                  80    

ggg gaa ctc ggt agt ctc tac ggg ccc ttg tcg gtc tcg gct tat gtg   824   
Gly Glu Leu Gly Ser Leu Tyr Gly Pro Leu Ser Val Ser Ala Tyr Val
             85                  90                  95        

gcc ggg atc ctg ggg ctt ggg gag gtc tac tcg ggg gtc ctc acc gtc   872   
Ala Gly Ile Leu Gly Leu Gly Glu Val Tyr Ser Gly Val Leu Thr Val
        100                 105                 110            

ggg gtg gcg ttg acg cgc agg gtc tac ccg gtc ccg aac ctg acg tgt   920   
Gly Val Ala Leu Thr Arg Arg Val Tyr Pro Val Pro Asn Leu Thr Cys
    115                 120                 125                

gca gta gag tgt gag ttg aag tgg gaa agt gag ttt tgg aga tgg act   968   
Ala Val Glu Cys Glu Leu Lys Trp Glu Ser Glu Phe Trp Arg Trp Thr
130                 135                 140                 145

gaa cag ctg gcc tca aac tac tgg att ctg gaa tac ctc tgg aag gtg   1016  
Glu Gln Leu Ala Ser Asn Tyr Trp Ile Leu Glu Tyr Leu Trp Lys Val
                150                 155                 160    

cct ttc gac ttt tgg cgg gga gtg atg agc ctt act cct ctc ttg gtg   1064  
Pro Phe Asp Phe Trp Arg Gly Val Met Ser Leu Thr Pro Leu Leu Val
            165                 170                 175        

tgc gtg gcg gcc ctc ctc ctg ctg gag cag cgt att gtc atg gtc ttc   1112  
Cys Val Ala Ala Leu Leu Leu Leu Glu Gln Arg Ile Val Met Val Phe
        180                 185                 190            

ctc ctg gtc act atg gcg ggc atg tcg caa ggc gcg ccc gcc tca gtg   1160  
Leu Leu Val Thr Met Ala Gly Met Ser Gln Gly Ala Pro Ala Ser Val
    195                 200                 205                

ttg ggg tca cgg cct ttc gag gcc ggg ttg act tgg cag tct tgt tct   1208  
Leu Gly Ser Arg Pro Phe Glu Ala Gly Leu Thr Trp Gln Ser Cys Ser
210                 215                 220                 225

tgc agg tcg aac ggg tcc cgc gtg ccg acg ggg gag agg gtt tgg gaa   1256  
Cys Arg Ser Asn Gly Ser Arg Val Pro Thr Gly Glu Arg Val Trp Glu
                230                 235                 240    

cgt ggg aac gtc aca ctt ttg tgt gac tgc ccc aac ggt cct tgg gtg   1304  
Arg Gly Asn Val Thr Leu Leu Cys Asp Cys Pro Asn Gly Pro Trp Val
            245                 250                 255        

tgg gtc ccg gcc ctt tgc cag gca atc gga tgg ggc gac cct atc act   1352  
Trp Val Pro Ala Leu Cys Gln Ala Ile Gly Trp Gly Asp Pro Ile Thr
        260                 265                 270            

cat tgg agc cac gga caa aat cag tgg ccc ctt tct tgt ccc caa ttt   1400  
His Trp Ser His Gly Gln Asn Gln Trp Pro Leu Ser Cys Pro Gln Phe
    275                 280                 285                

gtc tac ggc gcc gtt tca gtg acc tgc gtg tgg ggt tct gtg tct tgg   1448  
Val Tyr Gly Ala Val Ser Val Thr Cys Val Trp Gly Ser Val Ser Trp
290                 295                 300                 305

ttt gct tcc act ggg ggt cgc gac tcc aag gtt gat gtg tgg agt ttg   1496  
Phe Ala Ser Thr Gly Gly Arg Asp Ser Lys Val Asp Val Trp Ser Leu
                310                 315                 320    

gtt cca gtt ggc tct gcc agc tgc acc ata gcc gca ctg gga tct tcg   1544  
Val Pro Val Gly Ser Ala Ser Cys Thr Ile Ala Ala Leu Gly Ser Ser
            325                 330                 335        

gat cgc gac aca gtg gtt gag ctc tcc gag tgg gga att ccc tgc gcc   1592  
Asp Arg Asp Thr Val Val Glu Leu Ser Glu Trp Gly Ile Pro Cys Ala
        340                 345                 350            

act tgt atc ctg gac agg cgg cct gcc tcg tgt ggc acc tgt gtg agg   1640  
Thr Cys Ile Leu Asp Arg Arg Pro Ala Ser Cys Gly Thr Cys Val Arg
    355                 360                 365                

gac tgc tgg ccc gag acc ggg tcg gta cgt ttc cca ttc cac agg tgt   1688  
Asp Cys Trp Pro Glu Thr Gly Ser Val Arg Phe Pro Phe His Arg Cys
370                 375                 380                 385

ggc gcg gga ccg agg ctg acc aga gac ctt gag gct gtg ccc ttc gtc   1736  
Gly Ala Gly Pro Arg Leu Thr Arg Asp Leu Glu Ala Val Pro Phe Val
                390                 395                 400    

aat agg aca act ccc ttc acc ata agg ggg ccc ctg ggc aac cag ggg   1784  
Asn Arg Thr Thr Pro Phe Thr Ile Arg Gly Pro Leu Gly Asn Gln Gly
            405                 410                 415        

cga ggc aac ccg gtg cgg tcg ccc ttg ggt ttt ggg tcc tac acc atg   1832  
Arg Gly Asn Pro Val Arg Ser Pro Leu Gly Phe Gly Ser Tyr Thr Met
        420                 425                 430            

acc aag atc cga gac tcc tta cac ttg gtg aaa tgt ccc acc cca gcc   1880  
Thr Lys Ile Arg Asp Ser Leu His Leu Val Lys Cys Pro Thr Pro Ala
    435                 440                 445                

att gag cct ccc acc gga acg ttt ggg ttc ttc cca gga gtc ccc ccc   1928  
Ile Glu Pro Pro Thr Gly Thr Phe Gly Phe Phe Pro Gly Val Pro Pro
450                 455                 460                 465

ctt aac aac tgc atg ctt ctc ggc act gag gtg tca gag gta ttg ggt   1976  
Leu Asn Asn Cys Met Leu Leu Gly Thr Glu Val Ser Glu Val Leu Gly
                470                 475                 480    

ggg gcg ggc ctc act ggg ggg ttt tac gaa cct ctg gtg cgg cgg tgt   2024  
Gly Ala Gly Leu Thr Gly Gly Phe Tyr Glu Pro Leu Val Arg Arg Cys
            485                 490                 495        

tca gag ctg atg ggt cgg cgg aat ccg gtc tgc ccg ggg ttt gca tgg   2072  
Ser Glu Leu Met Gly Arg Arg Asn Pro Val Cys Pro Gly Phe Ala Trp
        500                 505                 510            

ctc tct tcg gga cgg cct gat ggg ttc ata cat gtt cag ggc cac ttg   2120  
Leu Ser Ser Gly Arg Pro Asp Gly Phe Ile His Val Gln Gly His Leu
    515                 520                 525                

cag gag gtg gat gcg ggc aac ttc att ccg ccc cca cgc tgg ttg ctc   2168  
Gln Glu Val Asp Ala Gly Asn Phe Ile Pro Pro Pro Arg Trp Leu Leu
530                 535                 540                 545

ttg gac ttt gta ttt gtc ctg tta tac ctg atg aag ctg gca gag gca   2216  
Leu Asp Phe Val Phe Val Leu Leu Tyr Leu Met Lys Leu Ala Glu Ala
                550                 555                 560    

cgg ttg gtc ccg ctg atc ctc ctc ctg cta tgg tgg tgg gtg aac cag   2264  
Arg Leu Val Pro Leu Ile Leu Leu Leu Leu Trp Trp Trp Val Asn Gln
            565                 570                 575        

ttg gcg gtc ctt gkt gtg scg gct gck crc gcc gcc gtg gct gga gag   2312  
Leu Ala Val Leu Xaa Val Xaa Ala Xaa Xaa Ala Ala Val Ala Gly Glu
        580                 585                 590            

gtg ttt gcg ggc cct gcc ttg tcc tgg tgt ctg ggc cta ccc ttc gtg   2360  
Val Phe Ala Gly Pro Ala Leu Ser Trp Cys Leu Gly Leu Pro Phe Val
    595                 600                 605                

agt atg atc ctg ggg cta gca aac ctg gtg ttg tac ttc cgc tgg atg   2408  
Ser Met Ile Leu Gly Leu Ala Asn Leu Val Leu Tyr Phe Arg Trp Met
610                 615                 620                 625

ggt cct caa cgc ctg atg ttc ctc gtg ttg tgg aag ctc gct cgg ggg   2456  
Gly Pro Gln Arg Leu Met Phe Leu Val Leu Trp Lys Leu Ala Arg Gly
                630                 635                 640    

gct ttc ccg ctg gca tta ctg atg ggg att tcc gcc act cgc ggc cgc   2504  
Ala Phe Pro Leu Ala Leu Leu Met Gly Ile Ser Ala Thr Arg Gly Arg
            645                 650                 655        

acc tct gtg ctt ggc gcc gaa ttc tgc ttt gat gtc acc ttt gaa gtg   2552  
Thr Ser Val Leu Gly Ala Glu Phe Cys Phe Asp Val Thr Phe Glu Val
        660                 665                 670            

gac acg tca gtc ttg ggt tgg gtg gtt gct agt gtg gtg gct tgg gcc   2600  
Asp Thr Ser Val Leu Gly Trp Val Val Ala Ser Val Val Ala Trp Ala
    675                 680                 685                

ata gcg ctc ctg agc tct atg agc gcg ggg ggg tgg aag cac aaa gcc   2648  
Ile Ala Leu Leu Ser Ser Met Ser Ala Gly Gly Trp Lys His Lys Ala
690                 695                 700                 705

ata atc tat agg acg tgg tgt aaa ggg tac cag gcy ctt cgc cag cgc   2696  
Ile Ile Tyr Arg Thr Trp Cys Lys Gly Tyr Gln Xaa Leu Arg Gln Arg
                710                 715                 720    

gtg gtg cgt agc ccc ctc ggg gag ggg cgg ccc acc aag ccg ctg acg   2744  
Val Val Arg Ser Pro Leu Gly Glu Gly Arg Pro Thr Lys Pro Leu Thr
            725                 730                 735        

ata gcc tgg tgt ctg gcc tct tac atc tgg ccg gac gct gtg atg ttg   2792  
Ile Ala Trp Cys Leu Ala Ser Tyr Ile Trp Pro Asp Ala Val Met Leu
        740                 745                 750            

gtg gtt gtg gcc atg gtc ctc ctc ttc ggc ctt ttc gac gcg ctc gat   2840  
Val Val Val Ala Met Val Leu Leu Phe Gly Leu Phe Asp Ala Leu Asp
    755                 760                 765                

tgg gcc ttg gag gag ctc ctt gtg tcg cgg cct tcg ttg cgt cgt ttg   2888  
Trp Ala Leu Glu Glu Leu Leu Val Ser Arg Pro Ser Leu Arg Arg Leu
770                 775                 780                 785

gca agg gtg gtg gag tgt tgt gtg atg gcg ggc gag aag gcc act acc   2936  
Ala Arg Val Val Glu Cys Cys Val Met Ala Gly Glu Lys Ala Thr Thr
                790                 795                 800    

gtc cgg ctt gtg tcc aag atg tgc gcg aga ggg gcc tac ctg ttt gac   2984  
Val Arg Leu Val Ser Lys Met Cys Ala Arg Gly Ala Tyr Leu Phe Asp
            805                 810                 815        

cac atg ggg tcg ttc tcg cgc gcg gtc aag gag cgc ttg ctg gag tgg   3032  
His Met Gly Ser Phe Ser Arg Ala Val Lys Glu Arg Leu Leu Glu Trp
        820                 825                 830            

gac gcg gct ttg gag mcc ctg tca ttc act agg acg gac tgt cgc atc   3080  
Asp Ala Ala Leu Glu Xaa Leu Ser Phe Thr Arg Thr Asp Cys Arg Ile
    835                 840                 845                

ata cga gac gcc gcc agg acc ctg agc tgc ggc caa tgc gtc atg ggc   3128  
Ile Arg Asp Ala Ala Arg Thr Leu Ser Cys Gly Gln Cys Val Met Gly
850                 855                 860                 865

ttg ccc gtg gtg gct agg cgc ggc gat gag gtc ctg att ggg gtc ttt   3176  
Leu Pro Val Val Ala Arg Arg Gly Asp Glu Val Leu Ile Gly Val Phe
                870                 875                 880    

cag gat gtg aac cac ttg cct ccg ggg ttt gyt cct aca gcg cct gtt   3224  
Gln Asp Val Asn His Leu Pro Pro Gly Phe Xaa Pro Thr Ala Pro Val
            885                 890                 895        

gtc atc cgt cgg tgc gga aag ggc ttc ctc ggg gtc act aag gct gcc   3272  
Val Ile Arg Arg Cys Gly Lys Gly Phe Leu Gly Val Thr Lys Ala Ala
        900                 905                 910            

ttg act ggt cgg gat cct gac tta cac cca gga aac gtc atg gtt ttg   3320  
Leu Thr Gly Arg Asp Pro Asp Leu His Pro Gly Asn Val Met Val Leu
    915                 920                 925                

ggg acg gct acc tcg cgc agc atg gga acg tgc tta aac ggg ttg ctg   3368  
Gly Thr Ala Thr Ser Arg Ser Met Gly Thr Cys Leu Asn Gly Leu Leu
930                 935                 940                 945

ttc acg aca ttc cat ggg gct tct tcc cga acc att gcg aca cct gtg   3416  
Phe Thr Thr Phe His Gly Ala Ser Ser Arg Thr Ile Ala Thr Pro Val
                950                 955                 960    

ggg gcc ctt aac cca agg tgg tgg tcg gcc agt gat gac gtc acg gtc   3464  
Gly Ala Leu Asn Pro Arg Trp Trp Ser Ala Ser Asp Asp Val Thr Val
            965                 970                 975        

tat ccc ctc ccc gat gga gct aac tcg ttg gtt ccc tgc tcg tgt cag   3512  
Tyr Pro Leu Pro Asp Gly Ala Asn Ser Leu Val Pro Cys Ser Cys Gln
        980                 985                 990            

gct gag tcc tgt tgg gtc aty cga tcc gat ggg gct ctt tgc cat ggc   3560  
Ala Glu Ser Cys Trp Val Xaa Arg Ser Asp Gly Ala Leu Cys His Gly
    995                1000                1005                

ttg agc aag ggg gac aag gta gaa ctg gac gtg gcc atg gag gtt gct   3608  
Leu Ser Lys Gly Asp Lys Val Glu Leu Asp Val Ala Met Glu Val Ala
1010               1015                1020                1025

gac ttt cgt ggg tcg tct ggg tct cct gtc cta tgc gac gag ggg cac   3656  
Asp Phe Arg Gly Ser Ser Gly Ser Pro Val Leu Cys Asp Glu Gly His
               1030                1035                1040    

gct gta gga atg ctc gtg tcc gtc ctt cat tcg ggg ggg agg gtg acc   3704  
Ala Val Gly Met Leu Val Ser Val Leu His Ser Gly Gly Arg Val Thr
           1045                1050                1055        

gcg gct cga ttc act cgg ccg tgg acc caa gtc cca aca gac gcc aag   3752  
Ala Ala Arg Phe Thr Arg Pro Trp Thr Gln Val Pro Thr Asp Ala Lys
       1060                1065                1070            

act acc act gag cca ccc ccg gtg cca gct aaa ggg gtt ttc aaa gag   3800  
Thr Thr Thr Glu Pro Pro Pro Val Pro Ala Lys Gly Val Phe Lys Glu
   1075                1080                1085                

gct cct ctt ttc atg cca aca ggg gcg ggg aaa agc aca cgc gtc cct   3848  
Ala Pro Leu Phe Met Pro Thr Gly Ala Gly Lys Ser Thr Arg Val Pro
1090               1095                1100                1105

ttg gag tat gga aac atg ggg cac aag gtc ctg att ctc aac ccg tcg   3896  
Leu Glu Tyr Gly Asn Met Gly His Lys Val Leu Ile Leu Asn Pro Ser
               1110                1115                1120    

gtt gcc act gtg agg gcc atg ggc cct tac atg gag agg ctg gcg ggg   3944  
Val Ala Thr Val Arg Ala Met Gly Pro Tyr Met Glu Arg Leu Ala Gly
           1125                1130                1135        

aaa cat cct agc att ttc tgt gga cac gac aca aca gct ttc aca cgg   3992  
Lys His Pro Ser Ile Phe Cys Gly His Asp Thr Thr Ala Phe Thr Arg
       1140                1145                1150            

atc acg gac tct cca ttg acg tac tct acc tat ggg agg ttt ctg gcc   4040  
Ile Thr Asp Ser Pro Leu Thr Tyr Ser Thr Tyr Gly Arg Phe Leu Ala
   1155                1160                1165                

aac ccg agg cag atg ctg agg gga gtt tcc gtg gtc atc tgt gat gag   4088  
Asn Pro Arg Gln Met Leu Arg Gly Val Ser Val Val Ile Cys Asp Glu
1170               1175                1180                1185

tgc cac agt cat gac tca act gtg ttg ctg ggt ata ggc agg gtc agg   4136  
Cys His Ser His Asp Ser Thr Val Leu Leu Gly Ile Gly Arg Val Arg
               1190                1195                1200    

gac gtg gcg cgg ggg tgt gga gtg caa tta gtg ctc tac gct act gcg   4184  
Asp Val Ala Arg Gly Cys Gly Val Gln Leu Val Leu Tyr Ala Thr Ala
           1205                1210                1215        

act ccc ccg ggc tcg cct atg act cag cat cca tcc ata att gag aca   4232  
Thr Pro Pro Gly Ser Pro Met Thr Gln His Pro Ser Ile Ile Glu Thr
       1220                1225                1230            

aag ctg gac gtt ggt gag atc ccc ttt tat ggg cat ggt atc ccc ctc   4280  
Lys Leu Asp Val Gly Glu Ile Pro Phe Tyr Gly His Gly Ile Pro Leu
   1235                1240                1245                

gag cgt atg agg act ggt cgc cac ctt gta ttc tgc cat tcc aag gcg   4328  
Glu Arg Met Arg Thr Gly Arg His Leu Val Phe Cys His Ser Lys Ala
1250               1255                1260                1265

gag tgc gag aga ttg gcc ggc cag ttc tcc gcg cgg ggg gtt aat gcc   4376  
Glu Cys Glu Arg Leu Ala Gly Gln Phe Ser Ala Arg Gly Val Asn Ala
               1270                1275                1280    

atc gcc tat tat agg ggt aag gac agt tcc atc atc aaa gac gga gac   4424  
Ile Ala Tyr Tyr Arg Gly Lys Asp Ser Ser Ile Ile Lys Asp Gly Asp
           1285                1290                1295        

ctg gtg gtt tgt gcg aca gac gcg ctc tct acc ggg tac aca gga aac   4472  
Leu Val Val Cys Ala Thr Asp Ala Leu Ser Thr Gly Tyr Thr Gly Asn
       1300                1305                1310            

ttc gat tct gtc acc gac tgt ggg ttg gtg gtg gag gag gtc gtt gag   4520  
Phe Asp Ser Val Thr Asp Cys Gly Leu Val Val Glu Glu Val Val Glu
   1315                1320                1325                

gtg acc ctt gat ccc acc att acc att tcc ttg cgg act gtc cct gct   4568  
Val Thr Leu Asp Pro Thr Ile Thr Ile Ser Leu Arg Thr Val Pro Ala
1330               1335                1340                1345

tcg gct gaa ttg tcg atg cag cgg cgc gga cgc acg ggg aga ggt cgg   4616  
Ser Ala Glu Leu Ser Met Gln Arg Arg Gly Arg Thr Gly Arg Gly Arg
               1350                1355                1360    

tcg ggc cgc tac tac tac gct ggg gtc ggt aag gct ccc gcg ggg gtg   4664  
Ser Gly Arg Tyr Tyr Tyr Ala Gly Val Gly Lys Ala Pro Ala Gly Val
           1365                1370                1375        

gtg cgg tct ggt ccg gtc tgg tcg gca gtg gaa gct gga gtg acc tgg   4712  
Val Arg Ser Gly Pro Val Trp Ser Ala Val Glu Ala Gly Val Thr Trp
       1380                1385                1390            

tat gga atg gaa cct gac ttg aca gca aac ctt ctg aga ctt tac gac   4760  
Tyr Gly Met Glu Pro Asp Leu Thr Ala Asn Leu Leu Arg Leu Tyr Asp
   1395                1400                1405                

gac tgc cct tac acc gca gcc gtc gca gct gac att ggt gaa gcc gcg   4808  
Asp Cys Pro Tyr Thr Ala Ala Val Ala Ala Asp Ile Gly Glu Ala Ala
1410               1415                1420                1425

gtg ttc ttt gcg ggc ctc gcg ccc ctc agg atg cat ccc gat gtt agc   4856  
Val Phe Phe Ala Gly Leu Ala Pro Leu Arg Met His Pro Asp Val Ser
               1430                1435                1440    

tgg gca aaa gtt cgc ggc gtc aat tgg ccc ctc ctg gtg ggt gtt cag   4904  
Trp Ala Lys Val Arg Gly Val Asn Trp Pro Leu Leu Val Gly Val Gln
           1445                1450                1455        

cgg acg atg tgt cgg gaa aca ctg tct ccc ggc ccg tcg gac gac cct   4952  
Arg Thr Met Cys Arg Glu Thr Leu Ser Pro Gly Pro Ser Asp Asp Pro
       1460                1465                1470            

cag tgg gca ggt ctg aaa ggc ccg aat cct gtc cca cta ctg ctg agg   5000  
Gln Trp Ala Gly Leu Lys Gly Pro Asn Pro Val Pro Leu Leu Leu Arg
   1475                1480                1485                

tgg ggc aat gat ttg cca tca aaa gtg gcc ggc cac cac ata gtt gac   5048  
Trp Gly Asn Asp Leu Pro Ser Lys Val Ala Gly His His Ile Val Asp
1490               1495                1500                1505

gat ctg gtc cgt cgg ctc ggt gtg gcg gag gga tac gtg cgc tgt gat   5096  
Asp Leu Val Arg Arg Leu Gly Val Ala Glu Gly Tyr Val Arg Cys Asp
               1510                1515                1520    

gct ggr ccc atc ctc atg gtg ggc ttg gcc ata gcg ggc ggc atg atc   5144  
Ala Xaa Pro Ile Leu Met Val Gly Leu Ala Ile Ala Gly Gly Met Ile
           1525                1530                1535        

tac gcc tct tac act ggg tcg cta gtg gtg gta aca gac tgg gat gtg   5192  
Tyr Ala Ser Tyr Thr Gly Ser Leu Val Val Val Thr Asp Trp Asp Val
       1540                1545                1550            

aag gga ggt ggc aat ccc ctt tat agg agt ggt gac cag gcc acc cct   5240  
Lys Gly Gly Gly Asn Pro Leu Tyr Arg Ser Gly Asp Gln Ala Thr Pro
   1555                1560                1565                

caa ccc gtg gtg cag gtc ccc ccg gta gac cat cgg ccg ggg ggg gag   5288  
Gln Pro Val Val Gln Val Pro Pro Val Asp His Arg Pro Gly Gly Glu
1570               1575                1580                1585

tct gcg cca cgg gat gcc aag aca gtg aca gat gcg gtg gca gcc atc   5336  
Ser Ala Pro Arg Asp Ala Lys Thr Val Thr Asp Ala Val Ala Ala Ile
               1590                1595                1600    

cag gtg aac tgc gat tgg tct gtg atg acc ctg tcg atc ggg gaa gtc   5384  
Gln Val Asn Cys Asp Trp Ser Val Met Thr Leu Ser Ile Gly Glu Val
           1605                1610                1615        

ctc acc ttg gct cag gct aag aca gcc gag gcc tac gca gct act tcc   5432  
Leu Thr Leu Ala Gln Ala Lys Thr Ala Glu Ala Tyr Ala Ala Thr Ser
       1620                1625                1630            

agg tgg ctc gct ggc tgc tac acg ggg acg cgg gcc gtc ccc act gta   5480  
Arg Trp Leu Ala Gly Cys Tyr Thr Gly Thr Arg Ala Val Pro Thr Val
   1635                1640                1645                

tca att gtt gac aag ctc ttc gcc ggg ggt tgg gcc gcc gtg gtg ggt   5528  
Ser Ile Val Asp Lys Leu Phe Ala Gly Gly Trp Ala Ala Val Val Gly
1650               1655                1660                1665

cac tgt cac agc gtc att gct gcg gcg gtg gct gcc tat gga gct tct   5576  
His Cys His Ser Val Ile Ala Ala Ala Val Ala Ala Tyr Gly Ala Ser
               1670                1675                1680    

cga agt cct cca ctg gcc gcg gcg gcg tcc tac ctc atg ggg ttg ggc   5624  
Arg Ser Pro Pro Leu Ala Ala Ala Ala Ser Tyr Leu Met Gly Leu Gly
           1685                1690                1695        

gtc gga ggc aac gca cag gcg cgc ttg gct tca gct ctt cta ctg ggg   5672  
Val Gly Gly Asn Ala Gln Ala Arg Leu Ala Ser Ala Leu Leu Leu Gly
       1700                1705                1710            

gct gct ggt acg gct ctg ggg acc cct gtc gtg gga ctc acc atg gcg   5720  
Ala Ala Gly Thr Ala Leu Gly Thr Pro Val Val Gly Leu Thr Met Ala
   1715                1720                1725                

ggg gcc ttc atg ggc ggt gcc agc gtg tcc ccc tcc ctc gtc act gtc   5768  
Gly Ala Phe Met Gly Gly Ala Ser Val Ser Pro Ser Leu Val Thr Val
1730               1735                1740                1745

cta ctt ggg gct gtg gga ggt tgg gag ggc gtt gtc aac gct gcc agt   5816  
Leu Leu Gly Ala Val Gly Gly Trp Glu Gly Val Val Asn Ala Ala Ser
               1750                1755                1760    

ctc gtc ttc gac ttc atg gct ggg aaa ctt tca aca gaa gac ctt tgg   5864  
Leu Val Phe Asp Phe Met Ala Gly Lys Leu Ser Thr Glu Asp Leu Trp
           1765                1770                1775        

tat gcc atc ccg gta ctc act agt cct ggr gcg ggc ctc gcg ggg att   5912  
Tyr Ala Ile Pro Val Leu Thr Ser Pro Xaa Ala Gly Leu Ala Gly Ile
       1780                1785                1790            

gcc ctt ggt ctg gtt ttg tac tca gca aac aac tct ggc act acc aca   5960  
Ala Leu Gly Leu Val Leu Tyr Ser Ala Asn Asn Ser Gly Thr Thr Thr
   1795                1800                1805                

tgg ctg aac cgt ctg ctg acg acg ttg cca cgg tca tct tgc ata ccc   6008  
Trp Leu Asn Arg Leu Leu Thr Thr Leu Pro Arg Ser Ser Cys Ile Pro
1810               1815                1820                1825

gac agc tac ttc caa cag gct gac tac tgc gac aag gtc tcg gca atc   6056  
Asp Ser Tyr Phe Gln Gln Ala Asp Tyr Cys Asp Lys Val Ser Ala Ile
               1830                1835                1840    

gtg cgc cgc ctg agc ctt act cgc acc gtg gtg gcc ctg gtc aac agg   6104  
Val Arg Arg Leu Ser Leu Thr Arg Thr Val Val Ala Leu Val Asn Arg
           1845                1850                1855        

gag cct aag gtg gat gag gtc cag gtg ggg tac gtc tgg gat ctg tgg   6152  
Glu Pro Lys Val Asp Glu Val Gln Val Gly Tyr Val Trp Asp Leu Trp
       1860                1865                1870            

gag tgg gtg atg cgc cag gtg cgc atg gtg atg tct aga ctc cgg gcc   6200  
Glu Trp Val Met Arg Gln Val Arg Met Val Met Ser Arg Leu Arg Ala
   1875                1880                1885                

ctc tgc cct gtg gtg tca ctc ccc ttg tgg cac tgc ggg gag ggg tgg   6248  
Leu Cys Pro Val Val Ser Leu Pro Leu Trp His Cys Gly Glu Gly Trp
1890               1895                1900                1905

tcc ggt gaa tgg ctt ctc gat ggg cac gtg gag agt cgt tgt ctg tgc   6296  
Ser Gly Glu Trp Leu Leu Asp Gly His Val Glu Ser Arg Cys Leu Cys
               1910                1915                1920    

ggg tgt gta atc acc ggc gac gtc ctc aat ggg caa ctc aaa gat cca   6344  
Gly Cys Val Ile Thr Gly Asp Val Leu Asn Gly Gln Leu Lys Asp Pro
           1925                1930                1935        

gtt tac tct acc aag ctg tgc agg cac tac tgg atg gga act gtg ccg   6392  
Val Tyr Ser Thr Lys Leu Cys Arg His Tyr Trp Met Gly Thr Val Pro
       1940                1945                1950            

gtc aac atg ctg ggc tac ggg gaa acc tca cct ctt ctc gcc tct gac   6440  
Val Asn Met Leu Gly Tyr Gly Glu Thr Ser Pro Leu Leu Ala Ser Asp
   1955                1960                1965                

acc ccg aag gtg gta ccc ttc ggg acg tcg ggg tgg gct gag gtg gtg   6488  
Thr Pro Lys Val Val Pro Phe Gly Thr Ser Gly Trp Ala Glu Val Val
1970               1975                1980                1985

gtg acc cct acc cac gtg gtg atc agg cgc acg tcc tgt tac aaa ctg   6536  
Val Thr Pro Thr His Val Val Ile Arg Arg Thr Ser Cys Tyr Lys Leu
               1990                1995                2000    

ctt cgc cag caa att ctt tca gca gct gta gct gag ccc tac tac gtt   6584  
Leu Arg Gln Gln Ile Leu Ser Ala Ala Val Ala Glu Pro Tyr Tyr Val
           2005                2010                2015        

gat ggc att ccg gtc tct tgg gag gct gac gcg aga gcg ccg gcc atg   6632  
Asp Gly Ile Pro Val Ser Trp Glu Ala Asp Ala Arg Ala Pro Ala Met
       2020                2025                2030            

gtc tac ggt ccg ggc caa agt gtt acc att gat ggg gag cgc tac acc   6680  
Val Tyr Gly Pro Gly Gln Ser Val Thr Ile Asp Gly Glu Arg Tyr Thr
   2035                2040                2045                

ctt ccg cac cag ttg cgg atg cgg aat gtg gcg ccc tct gag gtt tca   6728  
Leu Pro His Gln Leu Arg Met Arg Asn Val Ala Pro Ser Glu Val Ser
2050               2055                2060                2065

tct gag gtc agc atc gag atc ggg acg gag act gaa gac tca gaa ctg   6776  
Ser Glu Val Ser Ile Glu Ile Gly Thr Glu Thr Glu Asp Ser Glu Leu
               2070                2075                2080    

act gag gcc gat ttg cca cca gcg gct gct gcc ctc caa gcg ata gag   6824  
Thr Glu Ala Asp Leu Pro Pro Ala Ala Ala Ala Leu Gln Ala Ile Glu
           2085                2090                2095        

aat gct gcg aga att ctc gaa ccg cac atc gat gtc ayc atg gag gat   6872  
Asn Ala Ala Arg Ile Leu Glu Pro His Ile Asp Val Xaa Met Glu Asp
       2100                2105                2110            

tgc agt aca ccc tct ctc tgt ggt agt agc cga gag atg cct gtg tgg   6920  
Cys Ser Thr Pro Ser Leu Cys Gly Ser Ser Arg Glu Met Pro Val Trp
   2115                2120                2125                

gga gaa gac ata ccc cgc act cca tcg cct gca ctt atc tcg gtt acg   6968  
Gly Glu Asp Ile Pro Arg Thr Pro Ser Pro Ala Leu Ile Ser Val Thr
2130               2135                2140                2145

gag agc agc tca gat gag aag acc ctg tcg gtg acc tcc tcg cag gag   7016  
Glu Ser Ser Ser Asp Glu Lys Thr Leu Ser Val Thr Ser Ser Gln Glu
               2150                2155                2160    

gac acc ccg tcc tca gac tca ttt gaa gtc atc caa gag tct gat act   7064  
Asp Thr Pro Ser Ser Asp Ser Phe Glu Val Ile Gln Glu Ser Asp Thr
           2165                2170                2175        

gct gaa tca gag gaa agc gtc ttc aac gtg gct ctt tcc gta cta aaa   7112  
Ala Glu Ser Glu Glu Ser Val Phe Asn Val Ala Leu Ser Val Leu Lys
       2180                2185                2190            

gcc tta ttt cca cag agc gat gcc aca cga aag cta acg gtt aag atg   7160  
Ala Leu Phe Pro Gln Ser Asp Ala Thr Arg Lys Leu Thr Val Lys Met
   2195                2200                2205                

tct tgc tgt gtt gag aag agc gta aca cgc ttc ttt tct tta ggg ttg   7208  
Ser Cys Cys Val Glu Lys Ser Val Thr Arg Phe Phe Ser Leu Gly Leu
2210               2215                2220                2225

acc gtg gct gac gtg gct agc ctg tgt gag atg gag atc cag aac cat   7256  
Thr Val Ala Asp Val Ala Ser Leu Cys Glu Met Glu Ile Gln Asn His
               2230                2235                2240    

aca gcc tat tgt gac aag gtg cgc act ccg ctc gaa ttg caa gtt ggg   7304  
Thr Ala Tyr Cys Asp Lys Val Arg Thr Pro Leu Glu Leu Gln Val Gly
           2245                2250                2255        

tgc ttg gtg ggc aat gaa ctt acc ttt gaa tgt gac aag tgt gag gca   7352  
Cys Leu Val Gly Asn Glu Leu Thr Phe Glu Cys Asp Lys Cys Glu Ala
       2260                2265                2270            

cgc caa gag acc ctt gcc tcc ttc tcc tac ata tgg tcc ggg gtc cca   7400  
Arg Gln Glu Thr Leu Ala Ser Phe Ser Tyr Ile Trp Ser Gly Val Pro
   2275                2280                2285                

ctt act cgg gcc act ccg gcc aaa cca cca gtg gtg agg ccg gtg ggg   7448  
Leu Thr Arg Ala Thr Pro Ala Lys Pro Pro Val Val Arg Pro Val Gly
2290               2295                2300                2305

tcc ttg ttg gtg gca gac acc acc aag gtc tac gtg acc aat ccg gac   7496  
Ser Leu Leu Val Ala Asp Thr Thr Lys Val Tyr Val Thr Asn Pro Asp
               2310                2315                2320    

aat gtt ggg agg agg gtt gac aag gtg act ttc tgg cgc gct cct cgg   7544  
Asn Val Gly Arg Arg Val Asp Lys Val Thr Phe Trp Arg Ala Pro Arg
           2325                2330                2335        

gta cac gac aag ttc ctc gtg gac tcg atc gag cgc gct cgg aga gct   7592  
Val His Asp Lys Phe Leu Val Asp Ser Ile Glu Arg Ala Arg Arg Ala
       2340                2345                2350            

gct caa ggc tgc cta agc atg ggt tac act tat gag gag gca ata agg   7640  
Ala Gln Gly Cys Leu Ser Met Gly Tyr Thr Tyr Glu Glu Ala Ile Arg
   2355                2360                2365                

act gtt agg ccg cat gct gcc atg ggc tgg gga tct aag gtg tcg gtc   7688  
Thr Val Arg Pro His Ala Ala Met Gly Trp Gly Ser Lys Val Ser Val
2370               2375                2380                2385

aag gac ttg gcc acc cct gcg ggg aag atg gct gtt cat gac cgg ctt   7736  
Lys Asp Leu Ala Thr Pro Ala Gly Lys Met Ala Val His Asp Arg Leu
               2390                2395                2400    

cag gag ata ctt gaa ggg act ccg gtc cct ttt acc ctg act gtc aaa   7784  
Gln Glu Ile Leu Glu Gly Thr Pro Val Pro Phe Thr Leu Thr Val Lys
           2405                2410                2415        

aag gag gtg ttc ttc aaa gat cgt aag gag gag aag gcc ccc cgc ctc   7832  
Lys Glu Val Phe Phe Lys Asp Arg Lys Glu Glu Lys Ala Pro Arg Leu
       2420                2425                2430            

att gtg ttc ccc ccc ctg gac ttc cgg ata gct gaa aag ctc att ctg   7880  
Ile Val Phe Pro Pro Leu Asp Phe Arg Ile Ala Glu Lys Leu Ile Leu
   2435                2440                2445                

gga gac ccg ggg cgg gtt gca aag gcc ggt gtt ggg ggg gct tac gcc   7928  
Gly Asp Pro Gly Arg Val Ala Lys Ala Gly Val Gly Gly Ala Tyr Ala
2450               2455                2460                2465

ttc cag tac acc ccc aac cag cgg gtt aag gag atg cta aag ctg tgg   7976  
Phe Gln Tyr Thr Pro Asn Gln Arg Val Lys Glu Met Leu Lys Leu Trp
               2470                2475                2480    

gaa tca aag aag acc ccg tgc gcc atc tgt gtg gat gcc act tgc ttc   8024  
Glu Ser Lys Lys Thr Pro Cys Ala Ile Cys Val Asp Ala Thr Cys Phe
           2485                2490                2495        

gac agt agc att act gar gag gac gtg gca cta gag aca gag ctt tac   8072  
Asp Ser Ser Ile Thr Glu Glu Asp Val Ala Leu Glu Thr Glu Leu Tyr
       2500                2505                2510            

gcc ctg gcc tcg gac cat cca gaa tgg gtg cgc gcc ctg ggg aaa tac   8120  
Ala Leu Ala Ser Asp His Pro Glu Trp Val Arg Ala Leu Gly Lys Tyr
   2515                2520                2525                

trt gcc tct ggc aca atg gtg acc ccg gaa ggg gtg cca gtg ggc gag   8168  
Xaa Ala Ser Gly Thr Met Val Thr Pro Glu Gly Val Pro Val Gly Glu
2530               2535                2540                2545

agg tat tgt agg tcc tcg ggt gtg ttg acc aca agt gct agc aac tgt   8216  
Arg Tyr Cys Arg Ser Ser Gly Val Leu Thr Thr Ser Ala Ser Asn Cys
               2550                2555                2560    

ttg acc tgc tac atc aaa gtg aga gcc gcc tgt gag agg atc gga ctg   8264  
Leu Thr Cys Tyr Ile Lys Val Arg Ala Ala Cys Glu Arg Ile Gly Leu
           2565                2570                2575        

aaa aat gtc tcg ctt ctc atc gcg ggc gat gac tgc tta att gtg tgc   8312  
Lys Asn Val Ser Leu Leu Ile Ala Gly Asp Asp Cys Leu Ile Val Cys
       2580                2585                2590            

gag agg cct gta tgc gac cct tgc gag gcc ctg ggc cga acc ctg gct   8360  
Glu Arg Pro Val Cys Asp Pro Cys Glu Ala Leu Gly Arg Thr Leu Ala
   2595                2600                2605                

tcg tac ggg tac gcg tgt gag ccc tcg tat cac gct tca ctg gac aca   8408  
Ser Tyr Gly Tyr Ala Cys Glu Pro Ser Tyr His Ala Ser Leu Asp Thr
2610               2615                2620                2625

gcc ccc ttc tgc tcc act tgg ctc gct gag tgc aat gcg gat ggg raa   8456  
Ala Pro Phe Cys Ser Thr Trp Leu Ala Glu Cys Asn Ala Asp Gly Xaa
               2630                2635                2640    

agg cat ttc ttc ctg acc acg gac ttt cgg aga cca ctc gct cgc atg   8504  
Arg His Phe Phe Leu Thr Thr Asp Phe Arg Arg Pro Leu Ala Arg Met
           2645                2650                2655        

tcg agc gag tac agt gac cct atg gct tcg gcc att ggt tac att ctc   8552  
Ser Ser Glu Tyr Ser Asp Pro Met Ala Ser Ala Ile Gly Tyr Ile Leu
       2660                2665                2670            

ctc tac ccc tgg crt ccc atc aca cgg tgg gtc atc atc ccg cat gtg   8600  
Leu Tyr Pro Trp Xaa Pro Ile Thr Arg Trp Val Ile Ile Pro His Val
   2675                2680                2685                

cta aca tgc gct tct tcc cgg ggt ggt ggc aca csg tct gat ccg gtt   8648  
Leu Thr Cys Ala Ser Ser Arg Gly Gly Gly Thr Xaa Ser Asp Pro Val
2690               2695                2700                2705

tgg tgt cag gtt cat ggt aac tac tac aag ttt ccc ctg gac aaa ctg   8696  
Trp Cys Gln Val His Gly Asn Tyr Tyr Lys Phe Pro Leu Asp Lys Leu
               2710                2715                2720    

cct aac atc atc gtg gcc ctc cac gga cca gca gcg ttg agg gtt acc   8744  
Pro Asn Ile Ile Val Ala Leu His Gly Pro Ala Ala Leu Arg Val Thr
           2725                2730                2735        

gca gac aca acc aaa aca aag atg gag gct ggg aag gtt ctg agc gac   8792  
Ala Asp Thr Thr Lys Thr Lys Met Glu Ala Gly Lys Val Leu Ser Asp
       2740                2745                2750            

ctc aag ctc cct ggt cta gcc gtc cac cgc aag aag gcc ggg gca ttg   8840  
Leu Lys Leu Pro Gly Leu Ala Val His Arg Lys Lys Ala Gly Ala Leu
   2755                2760                2765                

cga aca cgc atg ctc cgg tcg cgc ggt tgg gcg gag ttg gct agg ggc   8888  
Arg Thr Arg Met Leu Arg Ser Arg Gly Trp Ala Glu Leu Ala Arg Gly
2770               2775                2780                2785

ctg ttg tgg cat cca gga ctc cgg ctt cct ccc cct gag att gct ggt   8936  
Leu Leu Trp His Pro Gly Leu Arg Leu Pro Pro Pro Glu Ile Ala Gly
               2790                2795                2800    

atc cca ggg ggt ttc cct ctg tcc ccc ccc tac atg ggg gtg gtt cat   8984  
Ile Pro Gly Gly Phe Pro Leu Ser Pro Pro Tyr Met Gly Val Val His
           2805                2810                2815        

caa ttg gat ttc aca gcs cag cgg agt cgc tgg cgg tgg ttg ggg ttc   9032  
Gln Leu Asp Phe Thr Xaa Gln Arg Ser Arg Trp Arg Trp Leu Gly Phe
       2820                2825                2830            

tta gcc ctg ctc atc gta gcg ctc ttt ggg tga actaaattca tctgttgcgg 9085  
Leu Ala Leu Leu Ile Val Ala Leu Phe Gly                          
   2835                2840                                      

caaggttgag cggctgatca ccgctcaagg aggttcccgc cctccccgcc ccaggggtct 9145  

ccccgctggg taaaaagggc ccggccttgg gaggcatggt ggttactaac cccctggcag 9205  

ggttaacgcc tgatggtgct aatgcactgc cgcttcggcg gcgggtcgct accttatagc 9265  

gtaatccgtg actacgggct gctcgcagag ccctccccgg atggggcaca gtgcactgtg 9325  

atctgaaggg gtgcaccccg gtaagagctc ggcccaaagg ccgggttcta ct         9377  


<210> 2
<211> 2843       
<212> PRT
<213> Hepatitis GB virus C

<220> 
<221> MOD_RES
<222> (30)..(2823)
<223> X = anything

<400> 2
Met Ala Val Leu Leu Leu Leu Leu Val Val Glu Ala Gly Ala Ile Leu  
  1               5                  10                  15      
Ala Pro Ala Thr His Ala Cys Ser Ala Lys Gly Gln Tyr Xaa Leu Thr  
             20                  25                  30          
Asn Cys Cys Ala Leu Glu Asp Ile Gly Phe Cys Leu Glu Gly Gly Cys  
         35                  40                  45              
Leu Val Ala Leu Gly Cys Thr Ile Cys Thr Asp Arg Cys Trp Pro Leu  
     50                  55                  60                  
Tyr Gln Ala Gly Leu Ala Val Arg Pro Gly Lys Ser Ala Ala Gln Leu  
 65                  70                  75                  80  
Val Gly Glu Leu Gly Ser Leu Tyr Gly Pro Leu Ser Val Ser Ala Tyr  
                 85                  90                  95      
Val Ala Gly Ile Leu Gly Leu Gly Glu Val Tyr Ser Gly Val Leu Thr  
            100                 105                 110          
Val Gly Val Ala Leu Thr Arg Arg Val Tyr Pro Val Pro Asn Leu Thr  
        115                 120                 125              
Cys Ala Val Glu Cys Glu Leu Lys Trp Glu Ser Glu Phe Trp Arg Trp  
    130                 135                 140                  
Thr Glu Gln Leu Ala Ser Asn Tyr Trp Ile Leu Glu Tyr Leu Trp Lys  
145                 150                 155                 160  
Val Pro Phe Asp Phe Trp Arg Gly Val Met Ser Leu Thr Pro Leu Leu  
                165                 170                 175      
Val Cys Val Ala Ala Leu Leu Leu Leu Glu Gln Arg Ile Val Met Val  
            180                 185                 190          
Phe Leu Leu Val Thr Met Ala Gly Met Ser Gln Gly Ala Pro Ala Ser  
        195                 200                 205              
Val Leu Gly Ser Arg Pro Phe Glu Ala Gly Leu Thr Trp Gln Ser Cys  
    210                 215                 220                  
Ser Cys Arg Ser Asn Gly Ser Arg Val Pro Thr Gly Glu Arg Val Trp  
225                 230                 235                 240  
Glu Arg Gly Asn Val Thr Leu Leu Cys Asp Cys Pro Asn Gly Pro Trp  
                245                 250                 255      
Val Trp Val Pro Ala Leu Cys Gln Ala Ile Gly Trp Gly Asp Pro Ile  
            260                 265                 270          
Thr His Trp Ser His Gly Gln Asn Gln Trp Pro Leu Ser Cys Pro Gln  
        275                 280                 285              
Phe Val Tyr Gly Ala Val Ser Val Thr Cys Val Trp Gly Ser Val Ser  
    290                 295                 300                  
Trp Phe Ala Ser Thr Gly Gly Arg Asp Ser Lys Val Asp Val Trp Ser  
305                 310                 315                 320  
Leu Val Pro Val Gly Ser Ala Ser Cys Thr Ile Ala Ala Leu Gly Ser  
                325                 330                 335      
Ser Asp Arg Asp Thr Val Val Glu Leu Ser Glu Trp Gly Ile Pro Cys  
            340                 345                 350          
Ala Thr Cys Ile Leu Asp Arg Arg Pro Ala Ser Cys Gly Thr Cys Val  
        355                 360                 365              
Arg Asp Cys Trp Pro Glu Thr Gly Ser Val Arg Phe Pro Phe His Arg  
    370                 375                 380                  
Cys Gly Ala Gly Pro Arg Leu Thr Arg Asp Leu Glu Ala Val Pro Phe  
385                 390                 395                 400  
Val Asn Arg Thr Thr Pro Phe Thr Ile Arg Gly Pro Leu Gly Asn Gln  
                405                 410                 415      
Gly Arg Gly Asn Pro Val Arg Ser Pro Leu Gly Phe Gly Ser Tyr Thr  
            420                 425                 430          
Met Thr Lys Ile Arg Asp Ser Leu His Leu Val Lys Cys Pro Thr Pro  
        435                 440                 445              
Ala Ile Glu Pro Pro Thr Gly Thr Phe Gly Phe Phe Pro Gly Val Pro  
    450                 455                 460                  
Pro Leu Asn Asn Cys Met Leu Leu Gly Thr Glu Val Ser Glu Val Leu  
465                 470                 475                 480  
Gly Gly Ala Gly Leu Thr Gly Gly Phe Tyr Glu Pro Leu Val Arg Arg  
                485                 490                 495      
Cys Ser Glu Leu Met Gly Arg Arg Asn Pro Val Cys Pro Gly Phe Ala  
            500                 505                 510          
Trp Leu Ser Ser Gly Arg Pro Asp Gly Phe Ile His Val Gln Gly His  
        515                 520                 525              
Leu Gln Glu Val Asp Ala Gly Asn Phe Ile Pro Pro Pro Arg Trp Leu  
    530                 535                 540                  
Leu Leu Asp Phe Val Phe Val Leu Leu Tyr Leu Met Lys Leu Ala Glu  
545                 550                 555                 560  
Ala Arg Leu Val Pro Leu Ile Leu Leu Leu Leu Trp Trp Trp Val Asn  
                565                 570                 575      
Gln Leu Ala Val Leu Xaa Val Xaa Ala Xaa Xaa Ala Ala Val Ala Gly  
            580                 585                 590          
Glu Val Phe Ala Gly Pro Ala Leu Ser Trp Cys Leu Gly Leu Pro Phe  
        595                 600                 605              
Val Ser Met Ile Leu Gly Leu Ala Asn Leu Val Leu Tyr Phe Arg Trp  
    610                 615                 620                  
Met Gly Pro Gln Arg Leu Met Phe Leu Val Leu Trp Lys Leu Ala Arg  
625                 630                 635                 640  
Gly Ala Phe Pro Leu Ala Leu Leu Met Gly Ile Ser Ala Thr Arg Gly  
                645                 650                 655      
Arg Thr Ser Val Leu Gly Ala Glu Phe Cys Phe Asp Val Thr Phe Glu  
            660                 665                 670          
Val Asp Thr Ser Val Leu Gly Trp Val Val Ala Ser Val Val Ala Trp  
        675                 680                 685              
Ala Ile Ala Leu Leu Ser Ser Met Ser Ala Gly Gly Trp Lys His Lys  
    690                 695                 700                  
Ala Ile Ile Tyr Arg Thr Trp Cys Lys Gly Tyr Gln Xaa Leu Arg Gln  
705                 710                 715                 720  
Arg Val Val Arg Ser Pro Leu Gly Glu Gly Arg Pro Thr Lys Pro Leu  
                725                 730                 735      
Thr Ile Ala Trp Cys Leu Ala Ser Tyr Ile Trp Pro Asp Ala Val Met  
            740                 745                 750          
Leu Val Val Val Ala Met Val Leu Leu Phe Gly Leu Phe Asp Ala Leu  
        755                 760                 765              
Asp Trp Ala Leu Glu Glu Leu Leu Val Ser Arg Pro Ser Leu Arg Arg  
    770                 775                 780                  
Leu Ala Arg Val Val Glu Cys Cys Val Met Ala Gly Glu Lys Ala Thr  
785                 790                 795                 800  
Thr Val Arg Leu Val Ser Lys Met Cys Ala Arg Gly Ala Tyr Leu Phe  
                805                 810                 815      
Asp His Met Gly Ser Phe Ser Arg Ala Val Lys Glu Arg Leu Leu Glu  
            820                 825                 830          
Trp Asp Ala Ala Leu Glu Xaa Leu Ser Phe Thr Arg Thr Asp Cys Arg  
        835                 840                 845              
Ile Ile Arg Asp Ala Ala Arg Thr Leu Ser Cys Gly Gln Cys Val Met  
    850                 855                 860                  
Gly Leu Pro Val Val Ala Arg Arg Gly Asp Glu Val Leu Ile Gly Val  
865                 870                 875                 880  
Phe Gln Asp Val Asn His Leu Pro Pro Gly Phe Xaa Pro Thr Ala Pro  
                885                 890                 895      
Val Val Ile Arg Arg Cys Gly Lys Gly Phe Leu Gly Val Thr Lys Ala  
            900                 905                 910          
Ala Leu Thr Gly Arg Asp Pro Asp Leu His Pro Gly Asn Val Met Val  
        915                 920                 925              
Leu Gly Thr Ala Thr Ser Arg Ser Met Gly Thr Cys Leu Asn Gly Leu  
    930                 935                 940                  
Leu Phe Thr Thr Phe His Gly Ala Ser Ser Arg Thr Ile Ala Thr Pro  
945                 950                 955                 960  
Val Gly Ala Leu Asn Pro Arg Trp Trp Ser Ala Ser Asp Asp Val Thr  
                965                 970                 975      
Val Tyr Pro Leu Pro Asp Gly Ala Asn Ser Leu Val Pro Cys Ser Cys  
            980                 985                 990          
Gln Ala Glu Ser Cys Trp Val Xaa Arg Ser Asp Gly Ala Leu Cys His  
        995                1000                1005              
Gly Leu Ser Lys Gly Asp Lys Val Glu Leu Asp Val Ala Met Glu Val  
   1010                1015                1020                  
Ala Asp Phe Arg Gly Ser Ser Gly Ser Pro Val Leu Cys Asp Glu Gly  
1025               1030                1035                1040  
His Ala Val Gly Met Leu Val Ser Val Leu His Ser Gly Gly Arg Val  
               1045                1050                1055      
Thr Ala Ala Arg Phe Thr Arg Pro Trp Thr Gln Val Pro Thr Asp Ala  
           1060                1065                1070          
Lys Thr Thr Thr Glu Pro Pro Pro Val Pro Ala Lys Gly Val Phe Lys  
       1075                1080                1085              
Glu Ala Pro Leu Phe Met Pro Thr Gly Ala Gly Lys Ser Thr Arg Val  
   1090                1095                1100                  
Pro Leu Glu Tyr Gly Asn Met Gly His Lys Val Leu Ile Leu Asn Pro  
1105               1110                1115                1120  
Ser Val Ala Thr Val Arg Ala Met Gly Pro Tyr Met Glu Arg Leu Ala  
               1125                1130                1135      
Gly Lys His Pro Ser Ile Phe Cys Gly His Asp Thr Thr Ala Phe Thr  
           1140                1145                1150          
Arg Ile Thr Asp Ser Pro Leu Thr Tyr Ser Thr Tyr Gly Arg Phe Leu  
       1155                1160                1165              
Ala Asn Pro Arg Gln Met Leu Arg Gly Val Ser Val Val Ile Cys Asp  
   1170                1175                1180                  
Glu Cys His Ser His Asp Ser Thr Val Leu Leu Gly Ile Gly Arg Val  
1185               1190                1195                1200  
Arg Asp Val Ala Arg Gly Cys Gly Val Gln Leu Val Leu Tyr Ala Thr  
               1205                1210                1215      
Ala Thr Pro Pro Gly Ser Pro Met Thr Gln His Pro Ser Ile Ile Glu  
           1220                1225                1230          
Thr Lys Leu Asp Val Gly Glu Ile Pro Phe Tyr Gly His Gly Ile Pro  
       1235                1240                1245              
Leu Glu Arg Met Arg Thr Gly Arg His Leu Val Phe Cys His Ser Lys  
   1250                1255                1260                  
Ala Glu Cys Glu Arg Leu Ala Gly Gln Phe Ser Ala Arg Gly Val Asn  
1265               1270                1275                1280  
Ala Ile Ala Tyr Tyr Arg Gly Lys Asp Ser Ser Ile Ile Lys Asp Gly  
               1285                1290                1295      
Asp Leu Val Val Cys Ala Thr Asp Ala Leu Ser Thr Gly Tyr Thr Gly  
           1300                1305                1310          
Asn Phe Asp Ser Val Thr Asp Cys Gly Leu Val Val Glu Glu Val Val  
       1315                1320                1325              
Glu Val Thr Leu Asp Pro Thr Ile Thr Ile Ser Leu Arg Thr Val Pro  
   1330                1335                1340                  
Ala Ser Ala Glu Leu Ser Met Gln Arg Arg Gly Arg Thr Gly Arg Gly  
1345               1350                1355                1360  
Arg Ser Gly Arg Tyr Tyr Tyr Ala Gly Val Gly Lys Ala Pro Ala Gly  
               1365                1370                1375      
Val Val Arg Ser Gly Pro Val Trp Ser Ala Val Glu Ala Gly Val Thr  
           1380                1385                1390          
Trp Tyr Gly Met Glu Pro Asp Leu Thr Ala Asn Leu Leu Arg Leu Tyr  
       1395                1400                1405              
Asp Asp Cys Pro Tyr Thr Ala Ala Val Ala Ala Asp Ile Gly Glu Ala  
   1410                1415                1420                  
Ala Val Phe Phe Ala Gly Leu Ala Pro Leu Arg Met His Pro Asp Val  
1425               1430                1435                1440  
Ser Trp Ala Lys Val Arg Gly Val Asn Trp Pro Leu Leu Val Gly Val  
               1445                1450                1455      
Gln Arg Thr Met Cys Arg Glu Thr Leu Ser Pro Gly Pro Ser Asp Asp  
           1460                1465                1470          
Pro Gln Trp Ala Gly Leu Lys Gly Pro Asn Pro Val Pro Leu Leu Leu  
       1475                1480                1485              
Arg Trp Gly Asn Asp Leu Pro Ser Lys Val Ala Gly His His Ile Val  
   1490                1495                1500                  
Asp Asp Leu Val Arg Arg Leu Gly Val Ala Glu Gly Tyr Val Arg Cys  
1505               1510                1515                1520  
Asp Ala Xaa Pro Ile Leu Met Val Gly Leu Ala Ile Ala Gly Gly Met  
               1525                1530                1535      
Ile Tyr Ala Ser Tyr Thr Gly Ser Leu Val Val Val Thr Asp Trp Asp  
           1540                1545                1550          
Val Lys Gly Gly Gly Asn Pro Leu Tyr Arg Ser Gly Asp Gln Ala Thr  
       1555                1560                1565              
Pro Gln Pro Val Val Gln Val Pro Pro Val Asp His Arg Pro Gly Gly  
   1570                1575                1580                  
Glu Ser Ala Pro Arg Asp Ala Lys Thr Val Thr Asp Ala Val Ala Ala  
1585               1590                1595                1600  
Ile Gln Val Asn Cys Asp Trp Ser Val Met Thr Leu Ser Ile Gly Glu  
               1605                1610                1615      
Val Leu Thr Leu Ala Gln Ala Lys Thr Ala Glu Ala Tyr Ala Ala Thr  
           1620                1625                1630          
Ser Arg Trp Leu Ala Gly Cys Tyr Thr Gly Thr Arg Ala Val Pro Thr  
       1635                1640                1645              
Val Ser Ile Val Asp Lys Leu Phe Ala Gly Gly Trp Ala Ala Val Val  
   1650                1655                1660                  
Gly His Cys His Ser Val Ile Ala Ala Ala Val Ala Ala Tyr Gly Ala  
1665               1670                1675                1680  
Ser Arg Ser Pro Pro Leu Ala Ala Ala Ala Ser Tyr Leu Met Gly Leu  
               1685                1690                1695      
Gly Val Gly Gly Asn Ala Gln Ala Arg Leu Ala Ser Ala Leu Leu Leu  
           1700                1705                1710          
Gly Ala Ala Gly Thr Ala Leu Gly Thr Pro Val Val Gly Leu Thr Met  
       1715                1720                1725              
Ala Gly Ala Phe Met Gly Gly Ala Ser Val Ser Pro Ser Leu Val Thr  
   1730                1735                1740                  
Val Leu Leu Gly Ala Val Gly Gly Trp Glu Gly Val Val Asn Ala Ala  
1745               1750                1755                1760  
Ser Leu Val Phe Asp Phe Met Ala Gly Lys Leu Ser Thr Glu Asp Leu  
               1765                1770                1775      
Trp Tyr Ala Ile Pro Val Leu Thr Ser Pro Xaa Ala Gly Leu Ala Gly  
           1780                1785                1790          
Ile Ala Leu Gly Leu Val Leu Tyr Ser Ala Asn Asn Ser Gly Thr Thr  
       1795                1800                1805              
Thr Trp Leu Asn Arg Leu Leu Thr Thr Leu Pro Arg Ser Ser Cys Ile  
   1810                1815                1820                  
Pro Asp Ser Tyr Phe Gln Gln Ala Asp Tyr Cys Asp Lys Val Ser Ala  
1825               1830                1835                1840  
Ile Val Arg Arg Leu Ser Leu Thr Arg Thr Val Val Ala Leu Val Asn  
               1845                1850                1855      
Arg Glu Pro Lys Val Asp Glu Val Gln Val Gly Tyr Val Trp Asp Leu  
           1860                1865                1870          
Trp Glu Trp Val Met Arg Gln Val Arg Met Val Met Ser Arg Leu Arg  
       1875                1880                1885              
Ala Leu Cys Pro Val Val Ser Leu Pro Leu Trp His Cys Gly Glu Gly  
   1890                1895                1900                  
Trp Ser Gly Glu Trp Leu Leu Asp Gly His Val Glu Ser Arg Cys Leu  
1905               1910                1915                1920  
Cys Gly Cys Val Ile Thr Gly Asp Val Leu Asn Gly Gln Leu Lys Asp  
               1925                1930                1935      
Pro Val Tyr Ser Thr Lys Leu Cys Arg His Tyr Trp Met Gly Thr Val  
           1940                1945                1950          
Pro Val Asn Met Leu Gly Tyr Gly Glu Thr Ser Pro Leu Leu Ala Ser  
       1955                1960                1965              
Asp Thr Pro Lys Val Val Pro Phe Gly Thr Ser Gly Trp Ala Glu Val  
   1970                1975                1980                  
Val Val Thr Pro Thr His Val Val Ile Arg Arg Thr Ser Cys Tyr Lys  
1985               1990                1995                2000  
Leu Leu Arg Gln Gln Ile Leu Ser Ala Ala Val Ala Glu Pro Tyr Tyr  
               2005                2010                2015      
Val Asp Gly Ile Pro Val Ser Trp Glu Ala Asp Ala Arg Ala Pro Ala  
           2020                2025                2030          
Met Val Tyr Gly Pro Gly Gln Ser Val Thr Ile Asp Gly Glu Arg Tyr  
       2035                2040                2045              
Thr Leu Pro His Gln Leu Arg Met Arg Asn Val Ala Pro Ser Glu Val  
   2050                2055                2060                  
Ser Ser Glu Val Ser Ile Glu Ile Gly Thr Glu Thr Glu Asp Ser Glu  
2065               2070                2075                2080  
Leu Thr Glu Ala Asp Leu Pro Pro Ala Ala Ala Ala Leu Gln Ala Ile  
               2085                2090                2095      
Glu Asn Ala Ala Arg Ile Leu Glu Pro His Ile Asp Val Xaa Met Glu  
           2100                2105                2110          
Asp Cys Ser Thr Pro Ser Leu Cys Gly Ser Ser Arg Glu Met Pro Val  
       2115                2120                2125              
Trp Gly Glu Asp Ile Pro Arg Thr Pro Ser Pro Ala Leu Ile Ser Val  
   2130                2135                2140                  
Thr Glu Ser Ser Ser Asp Glu Lys Thr Leu Ser Val Thr Ser Ser Gln  
2145               2150                2155                2160  
Glu Asp Thr Pro Ser Ser Asp Ser Phe Glu Val Ile Gln Glu Ser Asp  
               2165                2170                2175      
Thr Ala Glu Ser Glu Glu Ser Val Phe Asn Val Ala Leu Ser Val Leu  
           2180                2185                2190          
Lys Ala Leu Phe Pro Gln Ser Asp Ala Thr Arg Lys Leu Thr Val Lys  
       2195                2200                2205              
Met Ser Cys Cys Val Glu Lys Ser Val Thr Arg Phe Phe Ser Leu Gly  
   2210                2215                2220                  
Leu Thr Val Ala Asp Val Ala Ser Leu Cys Glu Met Glu Ile Gln Asn  
2225               2230                2235                2240  
His Thr Ala Tyr Cys Asp Lys Val Arg Thr Pro Leu Glu Leu Gln Val  
               2245                2250                2255      
Gly Cys Leu Val Gly Asn Glu Leu Thr Phe Glu Cys Asp Lys Cys Glu  
           2260                2265                2270          
Ala Arg Gln Glu Thr Leu Ala Ser Phe Ser Tyr Ile Trp Ser Gly Val  
       2275                2280                2285              
Pro Leu Thr Arg Ala Thr Pro Ala Lys Pro Pro Val Val Arg Pro Val  
   2290                2295                2300                  
Gly Ser Leu Leu Val Ala Asp Thr Thr Lys Val Tyr Val Thr Asn Pro  
2305               2310                2315                2320  
Asp Asn Val Gly Arg Arg Val Asp Lys Val Thr Phe Trp Arg Ala Pro  
               2325                2330                2335      
Arg Val His Asp Lys Phe Leu Val Asp Ser Ile Glu Arg Ala Arg Arg  
           2340                2345                2350          
Ala Ala Gln Gly Cys Leu Ser Met Gly Tyr Thr Tyr Glu Glu Ala Ile  
       2355                2360                2365              
Arg Thr Val Arg Pro His Ala Ala Met Gly Trp Gly Ser Lys Val Ser  
   2370                2375                2380                  
Val Lys Asp Leu Ala Thr Pro Ala Gly Lys Met Ala Val His Asp Arg  
2385               2390                2395                2400  
Leu Gln Glu Ile Leu Glu Gly Thr Pro Val Pro Phe Thr Leu Thr Val  
               2405                2410                2415      
Lys Lys Glu Val Phe Phe Lys Asp Arg Lys Glu Glu Lys Ala Pro Arg  
           2420                2425                2430          
Leu Ile Val Phe Pro Pro Leu Asp Phe Arg Ile Ala Glu Lys Leu Ile  
       2435                2440                2445              
Leu Gly Asp Pro Gly Arg Val Ala Lys Ala Gly Val Gly Gly Ala Tyr  
   2450                2455                2460                  
Ala Phe Gln Tyr Thr Pro Asn Gln Arg Val Lys Glu Met Leu Lys Leu  
2465               2470                2475                2480  
Trp Glu Ser Lys Lys Thr Pro Cys Ala Ile Cys Val Asp Ala Thr Cys  
               2485                2490                2495      
Phe Asp Ser Ser Ile Thr Glu Glu Asp Val Ala Leu Glu Thr Glu Leu  
           2500                2505                2510          
Tyr Ala Leu Ala Ser Asp His Pro Glu Trp Val Arg Ala Leu Gly Lys  
       2515                2520                2525              
Tyr Xaa Ala Ser Gly Thr Met Val Thr Pro Glu Gly Val Pro Val Gly  
   2530                2535                2540                  
Glu Arg Tyr Cys Arg Ser Ser Gly Val Leu Thr Thr Ser Ala Ser Asn  
2545               2550                2555                2560  
Cys Leu Thr Cys Tyr Ile Lys Val Arg Ala Ala Cys Glu Arg Ile Gly  
               2565                2570                2575      
Leu Lys Asn Val Ser Leu Leu Ile Ala Gly Asp Asp Cys Leu Ile Val  
           2580                2585                2590          
Cys Glu Arg Pro Val Cys Asp Pro Cys Glu Ala Leu Gly Arg Thr Leu  
       2595                2600                2605              
Ala Ser Tyr Gly Tyr Ala Cys Glu Pro Ser Tyr His Ala Ser Leu Asp  
   2610                2615                2620                  
Thr Ala Pro Phe Cys Ser Thr Trp Leu Ala Glu Cys Asn Ala Asp Gly  
2625               2630                2635                2640  
Xaa Arg His Phe Phe Leu Thr Thr Asp Phe Arg Arg Pro Leu Ala Arg  
               2645                2650                2655      
Met Ser Ser Glu Tyr Ser Asp Pro Met Ala Ser Ala Ile Gly Tyr Ile  
           2660                2665                2670          
Leu Leu Tyr Pro Trp Xaa Pro Ile Thr Arg Trp Val Ile Ile Pro His  
       2675                2680                2685              
Val Leu Thr Cys Ala Ser Ser Arg Gly Gly Gly Thr Xaa Ser Asp Pro  
   2690                2695                2700                  
Val Trp Cys Gln Val His Gly Asn Tyr Tyr Lys Phe Pro Leu Asp Lys  
2705               2710                2715                2720  
Leu Pro Asn Ile Ile Val Ala Leu His Gly Pro Ala Ala Leu Arg Val  
               2725                2730                2735      
Thr Ala Asp Thr Thr Lys Thr Lys Met Glu Ala Gly Lys Val Leu Ser  
           2740                2745                2750          
Asp Leu Lys Leu Pro Gly Leu Ala Val His Arg Lys Lys Ala Gly Ala  
       2755                2760                2765              
Leu Arg Thr Arg Met Leu Arg Ser Arg Gly Trp Ala Glu Leu Ala Arg  
   2770                2775                2780                  
Gly Leu Leu Trp His Pro Gly Leu Arg Leu Pro Pro Pro Glu Ile Ala  
2785               2790                2795                2800  
Gly Ile Pro Gly Gly Phe Pro Leu Ser Pro Pro Tyr Met Gly Val Val  
               2805                2810                2815      
His Gln Leu Asp Phe Thr Xaa Gln Arg Ser Arg Trp Arg Trp Leu Gly  
           2820                2825                2830          
Phe Leu Ala Leu Leu Ile Val Ala Leu Phe Gly                      
       2835                2840                                  



<210> 3
<211> 936
<212> DNA
<213> Hepatitis GB virus C

<220> 
<221> CDS
<222> (1)..(936)

<400> 3
acc ata gcc gca ctg gga tct tcg gat cgc gac aca gtg gtt gag ctc   48    
Thr Ile Ala Ala Leu Gly Ser Ser Asp Arg Asp Thr Val Val Glu Leu
  1               5                  10                  15    

tcc gag tgg gga att ccc tgc gcc act tgt atc ctg gac agg cgg cct   96    
Ser Glu Trp Gly Ile Pro Cys Ala Thr Cys Ile Leu Asp Arg Arg Pro
             20                  25                  30        

gcc tcg tgt ggc acc tgt gtg agg gac tgc tgg ccc gag acc ggg tcg   144   
Ala Ser Cys Gly Thr Cys Val Arg Asp Cys Trp Pro Glu Thr Gly Ser
         35                  40                  45            

gta cgt ttc cca ttc cac agg tgt ggc gcg gga ccg agg ctg acc aga   192   
Val Arg Phe Pro Phe His Arg Cys Gly Ala Gly Pro Arg Leu Thr Arg
     50                  55                  60                

gac ctt gag gct gtg ccc ttc gtc aat agg aca act ccc ttc acc ata   240   
Asp Leu Glu Ala Val Pro Phe Val Asn Arg Thr Thr Pro Phe Thr Ile
 65                  70                  75                  80

agg ggg ccc ctg ggc aac cag ggg cga ggc aac ccg gtg cgg tcg ccc   288   
Arg Gly Pro Leu Gly Asn Gln Gly Arg Gly Asn Pro Val Arg Ser Pro
                 85                  90                  95    

ttg ggt ttt ggg tcc tac acc atg acc aag atc cga gac tcc tta cac   336   
Leu Gly Phe Gly Ser Tyr Thr Met Thr Lys Ile Arg Asp Ser Leu His
            100                 105                 110        

ttg gtg aaa tgt ccc acc cca gcc att gag cct ccc acc gga acg ttt   384   
Leu Val Lys Cys Pro Thr Pro Ala Ile Glu Pro Pro Thr Gly Thr Phe
        115                 120                 125            

ggg ttc ttc cca gga gtc ccc ccc ctt aac aac tgc atg ctt ctc ggc   432   
Gly Phe Phe Pro Gly Val Pro Pro Leu Asn Asn Cys Met Leu Leu Gly
    130                 135                 140                

act gag gtg tca gag gta ttg ggt ggg gcg ggc ctc act ggg ggg ttt   480   
Thr Glu Val Ser Glu Val Leu Gly Gly Ala Gly Leu Thr Gly Gly Phe
145                 150                 155                 160

tac gaa cct ctg gtg cgg cgg tgt tca gag ctg atg ggt cgg cgg aat   528   
Tyr Glu Pro Leu Val Arg Arg Cys Ser Glu Leu Met Gly Arg Arg Asn
                165                 170                 175    

ccg gtc tgc ccg ggg ttt gca tgg ctc tct tcg gga cgg cct gat ggg   576   
Pro Val Cys Pro Gly Phe Ala Trp Leu Ser Ser Gly Arg Pro Asp Gly
            180                 185                 190        

ttc ata cat gtt cag ggc cac ttg cag gag gtg gat gcg ggc aac ttc   624   
Phe Ile His Val Gln Gly His Leu Gln Glu Val Asp Ala Gly Asn Phe
        195                 200                 205            

att ccg ccc cca cgc tgg ttg ctc ttg gac ttt gta ttt gtc ctg tta   672   
Ile Pro Pro Pro Arg Trp Leu Leu Leu Asp Phe Val Phe Val Leu Leu
    210                 215                 220                

tac ctg atg aag ctg gca gag gca cgg ttg gtc ccg ctg atc ctc ctc   720   
Tyr Leu Met Lys Leu Ala Glu Ala Arg Leu Val Pro Leu Ile Leu Leu
225                 230                 235                 240

ctg cta tgg tgg tgg gtg aac cag ttg gcg gtc ctt gkt gtg scg gct   768   
Leu Leu Trp Trp Trp Val Asn Gln Leu Ala Val Leu Xaa Val Xaa Ala
                245                 250                 255    

gck crc gcc gcc gtg gct gga gag gtg ttt gcg ggc cct gcc ttg tcc   816   
Xaa Xaa Ala Ala Val Ala Gly Glu Val Phe Ala Gly Pro Ala Leu Ser
            260                 265                 270        

tgg tgt ctg ggc cta ccc ttc gtg agt atg atc ctg ggg cta gca aac   864   
Trp Cys Leu Gly Leu Pro Phe Val Ser Met Ile Leu Gly Leu Ala Asn
        275                 280                 285            

ctg gtg ttg tac ttc cgc tgg atg ggt cct caa cgc ctg atg ttc ctc   912   
Leu Val Leu Tyr Phe Arg Trp Met Gly Pro Gln Arg Leu Met Phe Leu
    290                 295                 300                

gtg ttg tgg aag ctc gct cgg ggg                                   936   
Val Leu Trp Lys Leu Ala Arg Gly
305                 310        


<210> 4
<211> 312
<212> PRT
<213> Hepatitis GB virus C

<220> 
<221> MOD_RES
<222> (253)..(258)
<223> X = anything

<400> 4
Thr Ile Ala Ala Leu Gly Ser Ser Asp Arg Asp Thr Val Val Glu Leu  
  1               5                  10                  15      

Ser Glu Trp Gly Ile Pro Cys Ala Thr Cys Ile Leu Asp Arg Arg Pro  
             20                  25                  30          

Ala Ser Cys Gly Thr Cys Val Arg Asp Cys Trp Pro Glu Thr Gly Ser  
         35                  40                  45              

Val Arg Phe Pro Phe His Arg Cys Gly Ala Gly Pro Arg Leu Thr Arg  
     50                  55                  60                  

Asp Leu Glu Ala Val Pro Phe Val Asn Arg Thr Thr Pro Phe Thr Ile  
 65                  70                  75                  80  

Arg Gly Pro Leu Gly Asn Gln Gly Arg Gly Asn Pro Val Arg Ser Pro  
                 85                  90                  95      

Leu Gly Phe Gly Ser Tyr Thr Met Thr Lys Ile Arg Asp Ser Leu His  
            100                 105                 110          

Leu Val Lys Cys Pro Thr Pro Ala Ile Glu Pro Pro Thr Gly Thr Phe  
        115                 120                 125              

Gly Phe Phe Pro Gly Val Pro Pro Leu Asn Asn Cys Met Leu Leu Gly  
    130                 135                 140                  

Thr Glu Val Ser Glu Val Leu Gly Gly Ala Gly Leu Thr Gly Gly Phe  
145                 150                 155                 160  

Tyr Glu Pro Leu Val Arg Arg Cys Ser Glu Leu Met Gly Arg Arg Asn  
                165                 170                 175      

Pro Val Cys Pro Gly Phe Ala Trp Leu Ser Ser Gly Arg Pro Asp Gly  
            180                 185                 190          

Phe Ile His Val Gln Gly His Leu Gln Glu Val Asp Ala Gly Asn Phe  
        195                 200                 205              

Ile Pro Pro Pro Arg Trp Leu Leu Leu Asp Phe Val Phe Val Leu Leu  
    210                 215                 220                  

Tyr Leu Met Lys Leu Ala Glu Ala Arg Leu Val Pro Leu Ile Leu Leu  
225                 230                 235                 240  

Leu Leu Trp Trp Trp Val Asn Gln Leu Ala Val Leu Xaa Val Xaa Ala  
                245                 250                 255      

Xaa Xaa Ala Ala Val Ala Gly Glu Val Phe Ala Gly Pro Ala Leu Ser  
            260                 265                 270          

Trp Cys Leu Gly Leu Pro Phe Val Ser Met Ile Leu Gly Leu Ala Asn  
        275                 280                 285              

Leu Val Leu Tyr Phe Arg Trp Met Gly Pro Gln Arg Leu Met Phe Leu  
    290                 295                 300                  

Val Leu Trp Lys Leu Ala Arg Gly                                  
305                 310                                          



<210> 5
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence:  Synthetic
      Peptide

<400> 5
Leu Thr Gly Gly Phe Tyr Glu Pro Leu                              
  1               5                


<210> 6
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      Peptide

<400> 6
Gly Gly Ala Gly Leu Thr Gly Gly Phe Tyr Glu Pro Leu Val Arg Arg  
  1               5                  10                  15    

Cys                                                              
   


<210> 7
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      Peptide

<400> 7
Leu Thr Gly Gly Phe Tyr Glu Pro Leu Val Arg Arg Cys              
  1               5                  10            

<210> 8
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Description of Artificial Sequence: Synthetic
      Peptide

<400> 8
Phe Tyr Glu Pro Leu Val Arg Arg Cys              
  1               5                


<210> 9
<211> 415
<212> PRT
<213> Hepatitis GB virus C

<400> 9
Val Gly Tyr Val Trp Asp Leu Trp Glu Trp Ile Met Arg Gln Val Arg  
  1               5                  10                  15    

Met Val Met Ala Arg Leu Arg Ala Leu Cys Pro Val Val Ser Leu Pro  
             20                  25                  30        

Leu Trp His Cys Gly Glu Gly Trp Ser Gly Glu Trp Leu Leu Asp Gly  
         35                  40                  45            

His Val Glu Ser Arg Cys Leu Cys Gly Cys Val Ile Thr Gly Asp Val  
     50                  55                  60                

Leu Asn Gly Gln Leu Lys Glu Pro Val Tyr Ser Thr Lys Leu Cys Arg  
 65                  70                  75                  80

His Tyr Trp Met Gly Thr Val Pro Val Asn Met Leu Gly Tyr Gly Glu  
                 85                  90                  95    

Thr Ser Pro Leu Leu Ala Ser Asp Thr Pro Lys Val Val Pro Phe Gly  
            100                 105                 110        

Thr Ser Gly Trp Ala Glu Val Val Val Thr Pro Thr His Val Val Ile  
        115                 120                 125            

Arg Arg Thr Ser Ala Tyr Lys Leu Leu Arg Gln Gln Ile Leu Ser Ala  
    130                 135                 140                

Ala Val Ala Glu Pro Tyr Tyr Val Asp Gly Ile Pro Val Ser Trp Asp  
145                 150                 155                 160

Ala Asp Ala Arg Ala Pro Ala Met Val Tyr Gly Pro Gly Gln Ser Val  
                165                 170                 175    

Thr Ile Asp Gly Glu Arg Tyr Thr Leu Pro His Gln Leu Arg Leu Arg  
            180                 185                 190        

Asn Val Ala Pro Ser Glu Val Ser Ser Glu Val Ser Ile Asp Ile Gly  
        195                 200                 205            

Thr Glu Thr Glu Asp Ser Glu Leu Thr Glu Ala Asp Leu Pro Pro Ala  
    210                 215                 220                

Ala Ala Ala Leu Gln Ala Ile Glu Asn Ala Ala Arg Ile Leu Glu Pro  
225                 230                 235                 240

His Ile Asp Val Ile Met Glu Asp Cys Ser Thr Pro Ser Leu Cys Gly  
                245                 250                 255    

Ser Ser Arg Glu Met Pro Val Trp Gly Glu Asp Ile Pro Arg Thr Pro  
            260                 265                 270        

Ser Ser Pro Ala Leu Ile Ser Val Thr Glu Ser Pro Ser Asp Glu Lys  
        275                 280                 285            

Thr Pro Ser Val Ser Ser Ser Gln Glu Asp Thr Pro Ser Ser Asp Ser  
    290                 295                 300                

Phe Glu Val Ile Gln Glu Ser Glu Thr Ala Glu Gly Glu Glu Ser Val  
305                 310                 315                 320

Phe Asn Val Ala Leu Ser Val Leu Lys Ala Leu Phe Pro Gln Ser Asp  
                325                 330                 335    

Ala Thr Arg Lys Leu Thr Val Lys Met Ser Cys Cys Val Glu Lys Ser  
            340                 345                 350        

Val Thr Arg Phe Phe Ser Leu Gly Leu Thr Val Ala Asp Val Ala Ser  
        355                 360                 365            

Leu Cys Glu Met Glu Ile Gln Asn His Thr Ala Tyr Cys Asp Lys Val  
    370                 375                 380                

Arg Thr Pro Leu Glu Leu Gln Val Gly Cys Leu Val Gly Asn Glu Leu  
385                 390                 395                 400

Thr Phe Glu Cys His Asn Cys Glu Ala Arg Gln Glu Thr Leu Ala      
                405                 410                 415

