
                                SEQUENCE LISTING

<110> Repligen Corporation

<120> NUCLEIC ACIDS ENCODING RECOMBINANT
  PROTEIN A

<130> 00231-116WO1

<140> PCT/US2007/86692       
<141> 2007-12-06  

<150> US 60/873,191       
<151> 2006-12-06  

<160> 24

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 1272
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated oligonucleotide

<400> 1
atggcgcaac acgatgaagc tcaacagaac gctttttacc aggtactgaa catgccgaac 60
ctgaacgcgg atcagcgcaa cggtttcatc cagagcctga aagacgaccc ttctcagtcc 120
gcaaacgttc tgggcgaggc tcagaaactg aacgacagcc aggccccaaa agcagatgct 180
cagcaaaata acttcaacaa ggaccagcag agcgcattct acgaaatcct gaacatgcca 240
aatctgaacg aagctcaacg caacggcttc attcagtctc tgaaagacga tccgtcccag 300
tccactaacg ttctgggtga agctaagaag ctgaacgaat cccaggcacc aaaagcagac 360
aacaacttca acaaagagca gcagaacgct ttctatgaaa tcttgaacat gcctaacctg 420
aatgaagaac agcgtaacgg cttcatccag tctctgaagg acgaccctag ccagtctgct 480
aacctgctgt ccgaagcaaa aaaactgaac gagtcccagg ctccaaaagc ggataacaaa 540
ttcaacaagg agcagcagaa cgcattctac gaaatcctgc acctgccgaa cctgaacgaa 600
gaacagcgta acggtttcat ccaatccctg aaagacgatc cttcccagtc cgcaaatctg 660
ctggcagaag caaagaaact gaacgacgca caggcaccga aggctgacaa caagttcaac 720
aaagagcagc agaatgcctt ctacgagatt ctgcatctgc caaacctgac tgaggagcag 780
cgcaacggtt tcattcagtc cctgaaggac gacccaagcg tcagcaagga aatcctggct 840
gaggcgaaaa aactgaacga tgcacaggct ccgaaggaag aagacaacaa taaacctggt 900
aaagaagata ataataagcc tggcaaggaa gataacaaca agccgggcaa ggaggacaac 960
aataaaccgg gcaaagagga taataacaag cctggtaagg aagacaacaa caaaccaggc 1020
aaagaagatg gcaacaagcc gggtaaggag gataataaaa aaccaggcaa ggaagacggc 1080
aacaaacctg gcaaggagga taacaaaaag ccaggcaagg aggatggtaa taaaccgggc 1140
aaagaagacg gcaacaagcc tggtaaagaa gacggtaacg gtgtacacgt cgttaaacct 1200
ggtgacaccg tgaacgacat cgctaaggct aatggcacca cggcagacaa gattgcagcg 1260
gacaataaat aa                                                     1272

<210> 2
<211> 1523
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated oligonucleotide

<400> 2
atggcgcaac acgatgaagc tcaccagaac gctttttacc aggtactgaa catgccgaac 60
ctgaacgcgg atcagcgcaa cggtttcatc cagagcctga aagacgaccc ttctcagtcc 120
gcaaacgttc tgggcgaggc tcagaaactg aacgacagcc aggccccaaa agcagatgct 180
cagcaaaata acttcaacaa ggaccagcag agcgcattct acgaaatcct gaacatgcca 240
aatctgaacg aagctcaacg caacggcttc attcagtctc tgaaagacga tccgtcccag 300
tccactaacg ttctgggtga agctaagaag ctgaacgaat cccaggcacc aaaagcagac 360
aacaacttca acaaagagca gcagaacgct ttctatgaaa tcttgaacat gcctaacctg 420
aatgaagaac agcgtaacgg cttcatccag tctctgaagg acgaccctag ccagtctgct 480
aacctgctgt ccgaagcaaa aaaactgaac gagtcccagg ctccaaaagc ggataacaaa 540
ttcaacaagg agcagcagaa cgcattctac gaaatcctgc acctgccgaa cctgaacgaa 600
gaacagcgta acggtttcat ccaatccctg aaagacgatc cttcccagtc cgcaaatctg 660
ctggcagaag caaagaaact gaacgacgca caggcaccga aggctgacaa caagttcaac 720
aaagagcagc agaatgcctt ctacgagatt ctgcatctgc caaacctgac tgaggagcag 780
cgcaacggtt tcattcagtc cctgaaggac gacccaagcg tcagcaagga aatcctggct 840
gaggcgaaaa aactgaacga tgcacaggct ccgaaggaag aagacaacaa taaacctggt 900
aaagaagata ataataagcc tggcaaggaa gataacaaca agccgggcaa ggaggacaac 960
aataaaccgg gcaaagagga taataacaag cctggtaagg aagacaacaa caaaccaggc 1020
aaagaagatg gcaacaagcc gggtaaggag gataataaaa aaccaggcaa ggaagacggc 1080
aacaaacctg gcaaggagga taacaaaaag ccaggcaagg aggatggtaa taaaccgggc 1140
aaagaagacg gcaacaagcc tggtaaagaa gacggtaacg gtgtacacgt cgttaaacct 1200
ggtgacaccg tgaacgacat cgctaaggct aatggcacca cggcagacaa gattgcagcg 1260
gacaataaat tagctgataa ataaggatcc ggatccgtcg acaagcttcc cgggagctcg 1320
aattcttgaa gacgaaaggg cctcgtgata cgcctatttt tataggttaa tgtcatgata 1380
ataatggttt cttagacgtc ggtaccagcc cgcctaatga gcgggctttt ttttgacgtc 1440
aggtggcact tttcggggaa atgtgcgcgg aacccctatt tgtttatttt tctaaataca 1500
gaggaagaca acaacaagcc tgg                                         1523

<210> 3
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> A bacterial ribosome binding site

<400> 3
acgcgtggag gatgattaa                                              19

<210> 4
<211> 524
<212> PRT
<213> Staphylococcus aureus

<400> 4
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile
 1               5                  10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro
            20                  25                  30          
Ala Ala Asn Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys
                325                 330                 335     
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys
        355                 360                 365             
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
    370                 375                 380                 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
385                 390                 395                 400 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
                405                 410                 415     
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val
            420                 425                 430         
Val Lys Pro Gly Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr
        435                 440                 445             
Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met
    450                 455                 460                 
Ile Lys Pro Gly Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn
465                 470                 475                 480 
His Ala Asp Ala Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu
                485                 490                 495     
Asn Pro Phe Ile Gly Thr Thr Val Phe Gly Gly Leu Ser Leu Ala Leu
            500                 505                 510         
Gly Ala Ala Leu Leu Ala Gly Arg Arg Arg Glu Leu
        515                 520                 


<210> 5
<211> 422
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 5
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn
 1               5                  10                  15      
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu
            20                  25                  30          
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys
        35                  40                  45              
Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe
    50                  55                  60                  
Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn
65                  70                  75                  80  
Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp
                85                  90                  95      
Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu
            100                 105                 110         
Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn
        115                 120                 125             
Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg
    130                 135                 140                 
Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn
145                 150                 155                 160 
Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala
                165                 170                 175     
Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu
            180                 185                 190         
His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser
        195                 200                 205             
Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys
    210                 215                 220                 
Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys
225                 230                 235                 240 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr
                245                 250                 255     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser
            260                 265                 270         
Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln
        275                 280                 285             
Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
    290                 295                 300                 
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
305                 310                 315                 320 
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
                325                 330                 335     
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys
            340                 345                 350         
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys
        355                 360                 365             
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn
    370                 375                 380                 
Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly
385                 390                 395                 400 
Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys
                405                 410                 415     
Ile Ala Ala Asp Asn Lys
            420         


<210> 6
<211> 458
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 6
Met Lys Lys Lys Asn Ile Tyr Ser Ile Arg Lys Leu Gly Val Gly Ile
 1               5                  10                  15      
Ala Ser Val Thr Leu Gly Thr Leu Leu Ile Ser Gly Gly Val Thr Pro
            20                  25                  30          
Ala Ala Thr Ala Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr
        35                  40                  45              
Gln Val Leu Asn Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe
    50                  55                  60                  
Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly
65                  70                  75                  80  
Glu Ala Gln Lys Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln
                85                  90                  95      
Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu
            100                 105                 110         
Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser
        115                 120                 125             
Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys
    130                 135                 140                 
Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys
145                 150                 155                 160 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn
                165                 170                 175     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser
            180                 185                 190         
Gln Ser Ala Asn Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln
        195                 200                 205             
Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe
    210                 215                 220                 
Tyr Glu Ile Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly
225                 230                 235                 240 
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu
                245                 250                 255     
Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn
            260                 265                 270         
Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu
        275                 280                 285             
Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys
    290                 295                 300                 
Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu
305                 310                 315                 320 
Asn Asp Ala Gln Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys
                325                 330                 335     
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys
            340                 345                 350         
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys
        355                 360                 365             
Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
    370                 375                 380                 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
385                 390                 395                 400 
Glu Asp Asn Lys Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys
                405                 410                 415     
Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val
            420                 425                 430         
Val Lys Pro Gly Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr
        435                 440                 445             
Thr Ala Asp Lys Ile Ala Ala Asp Asn Lys
    450                 455             


<210> 7
<211> 426
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 7
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn
 1               5                  10                  15      
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu
            20                  25                  30          
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys
        35                  40                  45              
Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe
    50                  55                  60                  
Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn
65                  70                  75                  80  
Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp
                85                  90                  95      
Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu
            100                 105                 110         
Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn
        115                 120                 125             
Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg
    130                 135                 140                 
Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn
145                 150                 155                 160 
Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala
                165                 170                 175     
Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu
            180                 185                 190         
His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser
        195                 200                 205             
Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys
    210                 215                 220                 
Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys
225                 230                 235                 240 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr
                245                 250                 255     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser
            260                 265                 270         
Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln
        275                 280                 285             
Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
    290                 295                 300                 
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
305                 310                 315                 320 
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
                325                 330                 335     
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys
            340                 345                 350         
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys
        355                 360                 365             
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn
    370                 375                 380                 
Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly
385                 390                 395                 400 
Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys
                405                 410                 415     
Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys
            420                 425     


<210> 8
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<220>
<221> VARIANT        
<222> 7, 8
<223> Xaa = any amino acid

<400> 8
Lys Pro Gly Lys Glu Asp Xaa Xaa
 1               5              


<210> 9
<211> 56
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 9
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn
 1               5                  10                  15      
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu
            20                  25                  30          
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys
        35                  40                  45              
Leu Asn Asp Ser Gln Ala Pro Lys
    50                  55      


<210> 10
<211> 61
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 10
Ala Asp Ala Gln Gln Asn Asn Phe Asn Lys Asp Gln Gln Ser Ala Phe
 1               5                  10                  15      
Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Ala Gln Arg Asn Gly
            20                  25                  30          
Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Thr Asn Val Leu
        35                  40                  45              
Gly Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys
    50                  55                  60      


<210> 11
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 11
Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile
 1               5                  10                  15      
Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln
            20                  25                  30          
Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ser Glu Ala
        35                  40                  45              
Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys
    50                  55              


<210> 12
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 12
Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile
 1               5                  10                  15      
Leu His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln
            20                  25                  30          
Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala
        35                  40                  45              
Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys
    50                  55              


<210> 13
<211> 58
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 13
Ala Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile
 1               5                  10                  15      
Leu His Leu Pro Asn Leu Thr Glu Glu Gln Arg Asn Gly Phe Ile Gln
            20                  25                  30          
Ser Leu Lys Asp Asp Pro Ser Val Ser Lys Glu Ile Leu Ala Glu Ala
        35                  40                  45              
Lys Lys Leu Asn Asp Ala Gln Ala Pro Lys
    50                  55              


<210> 14
<211> 180
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 14
Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly
 1               5                  10                  15      
Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly
            20                  25                  30          
Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly
        35                  40                  45              
Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly
    50                  55                  60                  
Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly
65                  70                  75                  80  
Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly
                85                  90                  95      
Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val
            100                 105                 110         
Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala
        115                 120                 125             
Asp Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly Gln Glu Leu
    130                 135                 140                 
Val Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala Asn Lys Ala
145                 150                 155                 160 
Gln Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile Gly Thr Thr
                165                 170                 175     
Val Phe Gly Gly
            180 


<210> 15
<211> 131
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 15
Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly
 1               5                  10                  15      
Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly
            20                  25                  30          
Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly
        35                  40                  45              
Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly
    50                  55                  60                  
Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys Lys Pro Gly
65                  70                  75                  80  
Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly
                85                  90                  95      
Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly Asp Thr Val
            100                 105                 110         
Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys Ile Ala Ala
        115                 120                 125             
Asp Asn Lys
    130     


<210> 16
<211> 2270
<212> DNA
<213> Artificial Sequence

<220> 
<223> A partial nucleotide
      sequence of an E. coli expression vector.

<400> 16
gcagcggtcg ggctgaacgg ggggttcgtg cacacagccc agcttggagc gaacgaccta 60
caccgaactg agatacctac agcgtgagct atgagaaagc gccacgcttc ccgaagggag 120
aaaggcggac aggtatccgg taagcggcag ggtcggaaca ggagagcgca cgagggagct 180
tccaggggga aacgcctggt atctttatag tcctgtcggg tttcgccacc tctgacttga 240
gcgtcgattt ttgtgatgct cgtcaggggg gcggagccta tggaaaaacg ccagcaacgc 300
ggccttttta cggttcctgg ccttttgctg gccttttgct cacatgttct ttcctgcgtt 360
atcccctgat tctgtggata accgtattac cgcctttgag tgagctgata ccgctcgccg 420
cagccgaacg accgagcgca gcgagtcagt gagcgaggaa gcggaagagc gcctgatgcg 480
gtattttctc cttacgcatc tgtgcggtat ttcacaccgc atatgtcatg agagtttatc 540
gttcccaata cgctcgaacg aacgttcggt tgcttatttt atggcttctg tcaacgctgt 600
tttaaagatt aatgcgatct atatcacgct gtgggtattg cagtttttgg ttttttgatc 660
gcggtgtcag ttctttttat ttccatttct cttccatggg tttctcacag ataactgtgt 720
gcaacacaga attggttcga acgcgtggag gatgattaaa tggcgcaaca cgatgaagct 780
caacagaacg ctttttacca ggtactgaac atgccgaacc tgaacgcgga tcagcgcaac 840
ggtttcatcc agagcctgaa agacgaccct tctcagtccg caaacgttct gggcgaggct 900
cagaaactga acgacagcca ggccccaaaa gcagatgctc agcaaaataa cttcaacaag 960
gaccagcaga gcgcattcta cgaaatcctg aacatgccaa atctgaacga agctcaacgc 1020
aacggcttca ttcagtctct gaaagacgat ccgtcccagt ccactaacgt tctgggtgaa 1080
gctaagaagc tgaacgaatc ccaggcacca aaagcagaca acaacttcaa caaagagcag 1140
cagaacgctt tctatgaaat cttgaacatg cctaacctga atgaagaaca gcgtaacggc 1200
ttcatccagt ctctgaagga cgaccctagc cagtctgcta acctgctgtc cgaagcaaaa 1260
aaactgaacg agtcccaggc tccaaaagcg gataacaaat tcaacaagga gcagcagaac 1320
gcattctacg aaatcctgca cctgccgaac ctgaacgaag aacagcgtaa cggtttcatc 1380
caatccctga aagacgatcc ttcccagtcc gcaaatctgc tggcagaagc aaagaaactg 1440
aacgacgcac aggcaccgaa ggctgacaac aagttcaaca aagagcagca gaatgccttc 1500
tacgagattc tgcatctgcc aaacctgact gaggagcagc gcaacggttt cattcagtcc 1560
ctgaaggacg acccaagcgt cagcaaggaa atcctggctg aggcgaaaaa actgaacgat 1620
gcacaggctc cgaaggaaga agacaacaat aaacctggta aagaagataa taataagcct 1680
ggcaaggaag ataacaacaa gccgggcaag gaggacaaca ataaaccggg caaagaggat 1740
aataacaagc ctggtaagga agacaacaac aaaccaggca aagaagatgg caacaagccg 1800
ggtaaggagg ataataaaaa accaggcaag gaagacggca acaaacctgg caaggaggat 1860
aacaaaaagc caggcaagga ggatggtaat aaaccgggca aagaagacgg caacaagcct 1920
ggtaaagaag acggtaacgg tgtacacgtc gttaaacctg gtgacaccgt gaacgacatc 1980
gctaaggcta atggcaccac ggcagacaag attgcagcgg acaataaata aggatccgga 2040
tccgtcgaca agcttcccgg gagctcgaat tcttgaagac gaaagggcct cgtgatacgc 2100
ctatttttat aggttaatgt catgataata atggtttctt agacgtcggt accagcccgc 2160
ctaatgagcg ggcttttttt tgacgtcagg tggcactttt cggggaaatg tgcgcggaac 2220
ccctatttgt ttatttttct aaatacagag gaagacaaca acaagcctgg            2270

<210> 17
<211> 471
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 17
Ala Gln His Asp Glu Ala Gln Gln Asn Ala Phe Tyr Gln Val Leu Asn
 1               5                  10                  15      
Met Pro Asn Leu Asn Ala Asp Gln Arg Asn Gly Phe Ile Gln Ser Leu
            20                  25                  30          
Lys Asp Asp Pro Ser Gln Ser Ala Asn Val Leu Gly Glu Ala Gln Lys
        35                  40                  45              
Leu Asn Asp Ser Gln Ala Pro Lys Ala Asp Ala Gln Gln Asn Asn Phe
    50                  55                  60                  
Asn Lys Asp Gln Gln Ser Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn
65                  70                  75                  80  
Leu Asn Glu Ala Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp
                85                  90                  95      
Pro Ser Gln Ser Thr Asn Val Leu Gly Glu Ala Lys Lys Leu Asn Glu
            100                 105                 110         
Ser Gln Ala Pro Lys Ala Asp Asn Asn Phe Asn Lys Glu Gln Gln Asn
        115                 120                 125             
Ala Phe Tyr Glu Ile Leu Asn Met Pro Asn Leu Asn Glu Glu Gln Arg
    130                 135                 140                 
Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn
145                 150                 155                 160 
Leu Leu Ser Glu Ala Lys Lys Leu Asn Glu Ser Gln Ala Pro Lys Ala
                165                 170                 175     
Asp Asn Lys Phe Asn Lys Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu
            180                 185                 190         
His Leu Pro Asn Leu Asn Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser
        195                 200                 205             
Leu Lys Asp Asp Pro Ser Gln Ser Ala Asn Leu Leu Ala Glu Ala Lys
    210                 215                 220                 
Lys Leu Asn Asp Ala Gln Ala Pro Lys Ala Asp Asn Lys Phe Asn Lys
225                 230                 235                 240 
Glu Gln Gln Asn Ala Phe Tyr Glu Ile Leu His Leu Pro Asn Leu Thr
                245                 250                 255     
Glu Glu Gln Arg Asn Gly Phe Ile Gln Ser Leu Lys Asp Asp Pro Ser
            260                 265                 270         
Val Ser Lys Glu Ile Leu Ala Glu Ala Lys Lys Leu Asn Asp Ala Gln
        275                 280                 285             
Ala Pro Lys Glu Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
    290                 295                 300                 
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
305                 310                 315                 320 
Lys Pro Gly Lys Glu Asp Asn Asn Lys Pro Gly Lys Glu Asp Asn Asn
                325                 330                 335     
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys
            340                 345                 350         
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Asn Lys
        355                 360                 365             
Lys Pro Gly Lys Glu Asp Gly Asn Lys Pro Gly Lys Glu Asp Gly Asn
    370                 375                 380                 
Lys Pro Gly Lys Glu Asp Gly Asn Gly Val His Val Val Lys Pro Gly
385                 390                 395                 400 
Asp Thr Val Asn Asp Ile Ala Lys Ala Asn Gly Thr Thr Ala Asp Lys
                405                 410                 415     
Ile Ala Ala Asp Asn Lys Leu Ala Asp Lys Asn Met Ile Lys Pro Gly
            420                 425                 430         
Gln Glu Leu Val Val Asp Lys Lys Gln Pro Ala Asn His Ala Asp Ala
        435                 440                 445             
Asn Lys Ala Gln Ala Leu Pro Glu Thr Gly Glu Glu Asn Pro Phe Ile
    450                 455                 460                 
Gly Thr Thr Val Phe Gly Gly
465                 470     


<210> 18
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 18
aaagcagatg ctcagcaa                                               18

<210> 19
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 19
gatttccttg ctgacgctt                                              19

<210> 20
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 20
aagcgtcagc aaggaaatc                                              19

<210> 21
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Primer

<400> 21
gatctatatc acgctgtgg                                              19

<210> 22
<211> 1269
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated oligonucleotide

<400> 22
atggcgcaac acgatgaagc tcaacaaaat gctttttatc aagtcttaaa tatgcctaac 60
ttaaatgctg atcaacgcaa tggttttatc caaagcctta aagatgatcc aagccaaagt 120
gctaacgttt taggtgaagc tcaaaaactt aatgactctc aagctccaaa agctgatgcg 180
caacaaaata acttcaacaa agatcaacaa agcgccttct atgaaatctt gaacatgcct 240
aacttaaacg aagcgcaacg taacggcttc attcaaagtc ttaaagacga cccaagccaa 300
agcactaacg ttttaggtga agctaaaaaa ttaaacgaat ctcaagcacc gaaagctgat 360
aacaatttca acaaagaaca acaaaatgct ttctatgaaa tcttgaatat gcctaactta 420
aacgaagaac aacgcaatgg tttcatccaa agcttaaaag atgacccaag ccaaagtgct 480
aacctattgt cagaagctaa aaagttaaat gaatctcaag caccgaaagc ggataacaaa 540
ttcaacaaag aacaacaaaa tgctttctat gaaatcttac atttacctaa cttaaacgaa 600
gaacaacgca atggtttcat ccaaagccta aaagatgacc caagccaaag cgctaacctt 660
ttagcagaag ctaaaaagct aaatgatgct caagcaccaa aagctgacaa caaattcaac 720
aaagaacaac aaaatgcttt ctatgaaatt ttacatttac ctaacttaac tgaagaacaa 780
cgtaacggct tcatccaaag ccttaaagac gatccttcgg tgagcaaaga aattttagca 840
gaagctaaaa agctaaacga tgctcaagca ccaaaagagg aagacaataa caagcctggc 900
aaagaagaca ataacaagcc tggcaaagaa gacaataaca agcctggcaa agaagacaac 960
aacaagcctg gcaaagaaga caacaacaag cctggtaaag aagacaacaa caagcctggc 1020
aaagaagacg gcaacaagcc tggtaaagaa gacaacaaaa aacctggtaa agaagatggc 1080
aacaagcctg gtaaagaaga caacaaaaaa cctggtaaag aagacggcaa caagcctggc 1140
aaagaagatg gcaacaaacc tggtaaagaa gatggtaacg gagtacatgt cgttaaacct 1200
ggtgatacag taaatgacat tgcaaaagca aacggcacta ctgctgacaa aattgctgca 1260
gataacaaa                                                         1269

<210> 23
<211> 400
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetically generated oligonucleotide

<400> 23
tctgtgcggt atttcacacc gcatatgtca tgagagttta tcgttcccaa tacgctcgaa 60
cgaacgttcg gttgcttatt ttatggcttc tgtcaacgct gttttaaaga ttaatgcgat 120
ctatatcacg ctgtgggtat tgcagttttt cgttttttga tcgcggtgtc agttcttttt 180
atttccattt ctcttccatg ggtttctcac agataactgt gtgcaacaca gaattggttc 240
gaacgcgtgg aggatgatta aatggcgcaa cacgatgaag ctcaacagaa cgctttttac 300
caggtactga acatgccgaa ggacaataaa taaggatccg tcgacaagct tcccgggagc 360
tcgaattctt gaagacgaaa gggcctcgtg atacgcctat                       400

<210> 24
<211> 50
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetically generated peptide

<400> 24
Glu Arg Val Glu Asp Asp Met Ala Gln His Asp Glu Ala Gln Gln Asn
 1               5                  10                  15      
Ala Phe Tyr Gln Val Leu Asn Met Pro Asn Asp Asn Lys Gly Ser Val
            20                  25                  30          
Asp Lys Leu Pro Gly Ser Ser Asn Ser Arg Arg Lys Gly Leu Val Ile
        35                  40                  45              
Arg Leu
    50  







